P. Manoharan, K. Sethuraman, B. Adkoli, R. Saravanakumar
Dental curriculum in India needs to focus on clinical training of the students in workplace. With the rise of outcome-based education, competency-oriented systematic training with a multidimensional evaluation happens to be the need of the hour. The institutions and regulatory bodies should shift the focus of examination-oriented preparation of students to clinical-oriented training and evaluation.[1] Dr. RM Harden way back in 1984 has identified the strategies to impart training in workplace and equip the students with necessary skills to be a good decision maker and an effective clinician.[2] He has differentiated traditional approach to his approach by recommending a necessary shift needed from teacher centeredness to student centeredness, discipline based to integrated, information gathering to problem-solving, hospital based to community based, standard to elective, and opportunistic to systematic. In the literature, we see lot of deliberations on such strategies.[3-6] However, in the Indian scenario, we find that traditional system of education is still in practice. Owing to the economic situation, students may not have an exposure of rendering a better treatment plan which may be expensive. The student may choose a compromised plan with the limitations. Some institutions have implemented comprehensive clinical training of students. SPICES guidelines as proposed by Dr. RM Harden was used in the construction of curriculum for dental interns in an institution in India to evaluate the outcomes by the primary investigator. The time of intervention was from the year 2017 to 2018 for the regular and supplementary batches. O R I G I N A L A R T I C L E
{"title":"Perception of students and faculty toward a new curriculum based on SPICES model for dental interns","authors":"P. Manoharan, K. Sethuraman, B. Adkoli, R. Saravanakumar","doi":"10.15713/ins.jcri.278","DOIUrl":"https://doi.org/10.15713/ins.jcri.278","url":null,"abstract":"Dental curriculum in India needs to focus on clinical training of the students in workplace. With the rise of outcome-based education, competency-oriented systematic training with a multidimensional evaluation happens to be the need of the hour. The institutions and regulatory bodies should shift the focus of examination-oriented preparation of students to clinical-oriented training and evaluation.[1] Dr. RM Harden way back in 1984 has identified the strategies to impart training in workplace and equip the students with necessary skills to be a good decision maker and an effective clinician.[2] He has differentiated traditional approach to his approach by recommending a necessary shift needed from teacher centeredness to student centeredness, discipline based to integrated, information gathering to problem-solving, hospital based to community based, standard to elective, and opportunistic to systematic. In the literature, we see lot of deliberations on such strategies.[3-6] However, in the Indian scenario, we find that traditional system of education is still in practice. Owing to the economic situation, students may not have an exposure of rendering a better treatment plan which may be expensive. The student may choose a compromised plan with the limitations. Some institutions have implemented comprehensive clinical training of students. SPICES guidelines as proposed by Dr. RM Harden was used in the construction of curriculum for dental interns in an institution in India to evaluate the outcomes by the primary investigator. The time of intervention was from the year 2017 to 2018 for the regular and supplementary batches. O R I G I N A L A R T I C L E","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81030945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Curbing the tobacco menace – An oral diagnostician’s responsibility","authors":"Durga Rajaram Okade Acharya","doi":"10.15713/ins.jcri.254","DOIUrl":"https://doi.org/10.15713/ins.jcri.254","url":null,"abstract":"","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73364181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pragati K. Kempwade, S. Kattimani, D. Ramesh, Amit R Byatnal, Amruta Bansode, Karishma K. Mujawar
Aim: The aim of this study was to determine the prevalence of bifid condyle using digital panoramic radiographs and to evaluate correlation of bifid condyle with gender. Materials and Methods: Retrospective records of 1000 panoramic radiographs which were taken for their own diagnostic or treatment purpose in the Department of Oral Medicine and Radiology were evaluated by observer. Results: Among the 1000 radiographs studied, bifid condyles were found in 60 radiographs, giving an overall prevalence of bifid condyles as 6%. Among the population studied, 28 (2.8%) had unilateral bifid condyle and 32 (3.2%) had bilateral bifid condyle. There was no statistically significant difference in the prevalence of bifid condyles in males compared to females. Conclusion: The frequency of bifid condyle is higher in the North Karnataka population than previous studies. It is possible that bifid condyle is a more frequent condition that is commonly perceived. As it is asymptomatic condition, it usually remains incidental finding.
{"title":"Evaluation of the prevalence of bifid mandibular condyle detected on digital panoramic radiographs in North Karnataka region","authors":"Pragati K. Kempwade, S. Kattimani, D. Ramesh, Amit R Byatnal, Amruta Bansode, Karishma K. Mujawar","doi":"10.15713/ins.jcri.281","DOIUrl":"https://doi.org/10.15713/ins.jcri.281","url":null,"abstract":"Aim: The aim of this study was to determine the prevalence of bifid condyle using digital panoramic radiographs and to evaluate correlation of bifid condyle with gender. Materials and Methods: Retrospective records of 1000 panoramic radiographs which were taken for their own diagnostic or treatment purpose in the Department of Oral Medicine and Radiology were evaluated by observer. Results: Among the 1000 radiographs studied, bifid condyles were found in 60 radiographs, giving an overall prevalence of bifid condyles as 6%. Among the population studied, 28 (2.8%) had unilateral bifid condyle and 32 (3.2%) had bilateral bifid condyle. There was no statistically significant difference in the prevalence of bifid condyles in males compared to females. Conclusion: The frequency of bifid condyle is higher in the North Karnataka population than previous studies. It is possible that bifid condyle is a more frequent condition that is commonly perceived. As it is asymptomatic condition, it usually remains incidental finding.","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78482909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: An assortment of oral mucosal sores and conditions is related with the propensity for smoking and biting tobacco, and a large number of these convey a potential hazard for the advancement of disease. There have been no examinations that report the commonness of propensities and related oral changes in the populace in Dharwad district, Karnataka, South India. Aims and Objectives: This study aims to evaluate the effect of frequency, duration, and type of chewable tobacco products on the incidence and severity of oral lesions (leukoplakia, oral submucous fibrosis, and tobacco-induced lichenoid reaction) among the users in North Karnataka. Materials and Methods: A hospital-based, cross-sectional study was carried out at SDM Dental College (Dharwad, Karnataka). A total number of 90 subjects (30 patients with OSMF, 30 patients with leukoplakia, and 30 patients with tobacco-induced lichenoid reaction) attending the dental hospital were interviewed and examined by trained professionals to assess any oral mucosal changes. Results: Oral mucosal lesions were found in all the subjects who had tobacco chewing habits. Of 90 patients (65 males and 25 females), 40 patients had a habit of chewing betel quid with tobacco (44%) and 20 patients were gutkha chewers (22%) followed by 20 patients with a habit of chewing betel quid with areca nut (22%) and 10 patients with a habit of chewing pan masala (10%). The present study showed a higher frequency OSMF in patients with gutkha chewing habits (90%), whereas patients who had a habit of chewing tobacco with betel quid had more changes of leukoplakia (70%). It was also found that patients who had habit of chewing pan masala and betel quid with areca nut had more changes of lichenoid reaction. In the present study, we found that of all the 90 patients, 70% of the patients (63 patients) were asymptomatic, whereas 30% of the patients (27 patients) were symptomatic having complains of burning sensation (23 patients) and restricted mouth opening (4 patients). Conclusion: The study demonstrated that the danger of the advancement of oral lesions related with tobacco chewing is very high. The study fortifies the relationship of OSF with gutkha and areca nut biting while leukoplakia was normal in subjects who had a propensity for biting tobacco with betel quid that the risk of the development of oral lesions associated with tobacco chewing is quite high. The study reinforces the association of OSF with gutkha and areca nut chewing, whereas leukoplakia was common in subjects who had a habit of chewing tobacco with betel quid.
{"title":"Frequency of oral mucosal lesions among tobacco chewers: A cross-sectional survey","authors":"A. Yadav, K. Guttal, K. Burde","doi":"10.15713/INS.JCRI.256","DOIUrl":"https://doi.org/10.15713/INS.JCRI.256","url":null,"abstract":"Background: An assortment of oral mucosal sores and conditions is related with the propensity for smoking and biting tobacco, and a large number of these convey a potential hazard for the advancement of disease. There have been no examinations that report the commonness of propensities and related oral changes in the populace in Dharwad district, Karnataka, South India. Aims and Objectives: This study aims to evaluate the effect of frequency, duration, and type of chewable tobacco products on the incidence and severity of oral lesions (leukoplakia, oral submucous fibrosis, and tobacco-induced lichenoid reaction) among the users in North Karnataka. Materials and Methods: A hospital-based, cross-sectional study was carried out at SDM Dental College (Dharwad, Karnataka). A total number of 90 subjects (30 patients with OSMF, 30 patients with leukoplakia, and 30 patients with tobacco-induced lichenoid reaction) attending the dental hospital were interviewed and examined by trained professionals to assess any oral mucosal changes. Results: Oral mucosal lesions were found in all the subjects who had tobacco chewing habits. Of 90 patients (65 males and 25 females), 40 patients had a habit of chewing betel quid with tobacco (44%) and 20 patients were gutkha chewers (22%) followed by 20 patients with a habit of chewing betel quid with areca nut (22%) and 10 patients with a habit of chewing pan masala (10%). The present study showed a higher frequency OSMF in patients with gutkha chewing habits (90%), whereas patients who had a habit of chewing tobacco with betel quid had more changes of leukoplakia (70%). It was also found that patients who had habit of chewing pan masala and betel quid with areca nut had more changes of lichenoid reaction. In the present study, we found that of all the 90 patients, 70% of the patients (63 patients) were asymptomatic, whereas 30% of the patients (27 patients) were symptomatic having complains of burning sensation (23 patients) and restricted mouth opening (4 patients). Conclusion: The study demonstrated that the danger of the advancement of oral lesions related with tobacco chewing is very high. The study fortifies the relationship of OSF with gutkha and areca nut biting while leukoplakia was normal in subjects who had a propensity for biting tobacco with betel quid that the risk of the development of oral lesions associated with tobacco chewing is quite high. The study reinforces the association of OSF with gutkha and areca nut chewing, whereas leukoplakia was common in subjects who had a habit of chewing tobacco with betel quid.","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86736938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Gopinath, V. Shivakumar, Sayada Fatema, R. A. Dede, Shriniwas D. Maindad, S. Palla
{"title":"A comparative evaluation of salivary albumin levels in periodontally healthy and chronic periodontitis patients: A clinicobiochemical study","authors":"V. Gopinath, V. Shivakumar, Sayada Fatema, R. A. Dede, Shriniwas D. Maindad, S. Palla","doi":"10.15713/ins.jcri.283","DOIUrl":"https://doi.org/10.15713/ins.jcri.283","url":null,"abstract":"","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88535503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Etiological factors for periodontal diseases are multifactorial and one of these etiologic agents is bacteria. Mechanical therapy itself may not eliminate the anaerobic infection at the base of the pocket. To overcome this, various drug delivered locally have been used in adjunct to scaling and root planing (SRP). The present trial aims to evaluate the efficacy of 1.2% rosuvastatin (RSV) gel locally delivered as an adjunct to SRP in smokers with chronic periodontitis (CP). Materials and Methods: A total of 60 patients were randomly divided into two treatment groups: SRP with plac-ebo gel (Group 1) and SRP with 1.2% RSV gel (Group 2). Clinical parameters were evaluated at baseline, 3, 6, and 9 months. Radioic assessment was done at baseline and 6 and 9 months using computer-aided software. Results: As compared to placebo group, a significant greater mean probing depth reduction and greater mean gain in clinical attachment level were seen in the RSV group at different time periods. Moreover, a greater mean defect depth reduction was found in the RSV group (23.91 ± 1.03, 29.24 ± 0.834) after 6 and 9 months, respectively. Conclusion: Smokers with CP patients showed significant improvement in evaluated clinical parameters in RSV group with greater percentage of defect depth reduction as compared to placebo group.
{"title":"1.2% rosuvastatin gel as a local drug delivery agent in smokers with chronic periodontitis – A randomized controlled clinical trial","authors":"Dharmendra Kanoriya, N. Bajaj, A. R. Pradeep","doi":"10.15713/ins.jcri.272","DOIUrl":"https://doi.org/10.15713/ins.jcri.272","url":null,"abstract":"Background: Etiological factors for periodontal diseases are multifactorial and one of these etiologic agents is bacteria. Mechanical therapy itself may not eliminate the anaerobic infection at the base of the pocket. To overcome this, various drug delivered locally have been used in adjunct to scaling and root planing (SRP). The present trial aims to evaluate the efficacy of 1.2% rosuvastatin (RSV) gel locally delivered as an adjunct to SRP in smokers with chronic periodontitis (CP). Materials and Methods: A total of 60 patients were randomly divided into two treatment groups: SRP with plac-ebo gel (Group 1) and SRP with 1.2% RSV gel (Group 2). Clinical parameters were evaluated at baseline, 3, 6, and 9 months. Radioic assessment was done at baseline and 6 and 9 months using computer-aided software. Results: As compared to placebo group, a significant greater mean probing depth reduction and greater mean gain in clinical attachment level were seen in the RSV group at different time periods. Moreover, a greater mean defect depth reduction was found in the RSV group (23.91 ± 1.03, 29.24 ± 0.834) after 6 and 9 months, respectively. Conclusion: Smokers with CP patients showed significant improvement in evaluated clinical parameters in RSV group with greater percentage of defect depth reduction as compared to placebo group.","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78266633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. R. R. Varma, B. Harsha, S. Palla, S. Sravan, J. Raju, K. Rajavardhan
Genetics is the science concerned with the structure and function of all genes in different organisms. Malocclusion is a manifestation of genetic and environmental interaction on the development of the orofacial region. It is important to consider genetic factors to understand the cause of existing problems, which has influence the outcome of treatment. The review aims to provide information to the dental practitioner and orthodontist on basics of genetics and common disorders with gene impairments. These genetic factors in turn have an impact on outcome of orthodontic treatment. Introduction to Basics of Genetics Growth is the combined result of interaction between several genetic and environmental factors overtime.[1] Malocclusion is a manifestation of genetic and environmental interaction on the development of the orofacial region. It is important to consider genetic factors to understand the cause of existing problems, which influences the outcome of treatment.[2] Genetics is the science concerned with the structure and function of all genes. Austrian monk, Gregor John Mendel was known as “father of modern genetics.” The studies by Mendel, on garden pea, he put forward basic laws of genetics, namely law of segregation, law of independent assortment, and law of dominance. In 1903, Sulton and Boveri proposed the “Chromosomal Theory of Inheritance.”[2] Thomas Hunt Morgan studied the arrangement of genes along chromosomes. In 1953, Watson and Crick demonstrated the structure of DNA molecule. Solenoid model of chromosome was proposed by Finch and Klung.[2,3] The cell is the basic unit of any living body. It is made of organelles such as cell wall cytoplasm, endoplasmic reticulum, ribosomes, mitochondria, and nucleus. The nucleus has threadlike structures of different length and shapes called chromosomes. The number of chromosomes in every cell of an organism is constant, and it changes from one species to another. All humans normally have 23 pairs of chromosomes as 22 pairs of autosomes and one pair of sex chromosomes. Females have two X chromosomes, while male has one Xand one Y-chromosome. Gene is the smallest structural and functional unit of inheritance. Segment contains information required for the synthesis of a polypeptide. Genes have the ability to determine traits and undergo identical replication and mutation. Genome is the entire genetic content of a set of chromosomes present within a cell or organism. The genome varies from one individual to another in terms of single base changes of DNA as single-nucleotide polymorphisms (SNPs). The main use of human SNP map will be to determine the contribution of genes to diseases. Transcription is the process by which information is transmitted from DNA to the messenger RNA at the initial stages of replication and translation is the process in which the genetic information is actually converted into proteins. Transcription
{"title":"Genetics in an orthodontic perspective","authors":"G. R. R. Varma, B. Harsha, S. Palla, S. Sravan, J. Raju, K. Rajavardhan","doi":"10.15713/ins.jcri.267","DOIUrl":"https://doi.org/10.15713/ins.jcri.267","url":null,"abstract":"Genetics is the science concerned with the structure and function of all genes in different organisms. Malocclusion is a manifestation of genetic and environmental interaction on the development of the orofacial region. It is important to consider genetic factors to understand the cause of existing problems, which has influence the outcome of treatment. The review aims to provide information to the dental practitioner and orthodontist on basics of genetics and common disorders with gene impairments. These genetic factors in turn have an impact on outcome of orthodontic treatment. Introduction to Basics of Genetics Growth is the combined result of interaction between several genetic and environmental factors overtime.[1] Malocclusion is a manifestation of genetic and environmental interaction on the development of the orofacial region. It is important to consider genetic factors to understand the cause of existing problems, which influences the outcome of treatment.[2] Genetics is the science concerned with the structure and function of all genes. Austrian monk, Gregor John Mendel was known as “father of modern genetics.” The studies by Mendel, on garden pea, he put forward basic laws of genetics, namely law of segregation, law of independent assortment, and law of dominance. In 1903, Sulton and Boveri proposed the “Chromosomal Theory of Inheritance.”[2] Thomas Hunt Morgan studied the arrangement of genes along chromosomes. In 1953, Watson and Crick demonstrated the structure of DNA molecule. Solenoid model of chromosome was proposed by Finch and Klung.[2,3] The cell is the basic unit of any living body. It is made of organelles such as cell wall cytoplasm, endoplasmic reticulum, ribosomes, mitochondria, and nucleus. The nucleus has threadlike structures of different length and shapes called chromosomes. The number of chromosomes in every cell of an organism is constant, and it changes from one species to another. All humans normally have 23 pairs of chromosomes as 22 pairs of autosomes and one pair of sex chromosomes. Females have two X chromosomes, while male has one Xand one Y-chromosome. Gene is the smallest structural and functional unit of inheritance. Segment contains information required for the synthesis of a polypeptide. Genes have the ability to determine traits and undergo identical replication and mutation. Genome is the entire genetic content of a set of chromosomes present within a cell or organism. The genome varies from one individual to another in terms of single base changes of DNA as single-nucleotide polymorphisms (SNPs). The main use of human SNP map will be to determine the contribution of genes to diseases. Transcription is the process by which information is transmitted from DNA to the messenger RNA at the initial stages of replication and translation is the process in which the genetic information is actually converted into proteins. Transcription","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77209983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Sangeetha, Kiran Mitra, Umesh Yadalam, S. Narayan
It has been a topic of debate among dental care professionals, if trauma from occlusion is linked with periodontal disease or not. There are several schools of thought related to if trauma from occlusion is an etiological factor or cofactor for the occurrence of periodontal diseases. The present review article discusses historical background, etiological factors, classification
{"title":"Current concepts of trauma from occlusion - A review","authors":"S. Sangeetha, Kiran Mitra, Umesh Yadalam, S. Narayan","doi":"10.15713/ins.jcri.250","DOIUrl":"https://doi.org/10.15713/ins.jcri.250","url":null,"abstract":"It has been a topic of debate among dental care professionals, if trauma from occlusion is linked with periodontal disease or not. There are several schools of thought related to if trauma from occlusion is an etiological factor or cofactor for the occurrence of periodontal diseases. The present review article discusses historical background, etiological factors, classification","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79308654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case report on oral leukoplakia with superadded fungal infection","authors":"Mahalaxmi L. Lature, K. Burde","doi":"10.15713/ins.jcri.261","DOIUrl":"https://doi.org/10.15713/ins.jcri.261","url":null,"abstract":"","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83113650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anuja Anil Shinge, Preeti Kanchan-Talreja, D. Das, Amita Navalkar, Prakash S. Talreja, Ashutosh Kakade
Background: Oral submucous fibrosis (OSF) is a chronic, disabling disease involving the entire oral mucosa, mainly reported in Indian population. A number of treatment modalities have been tried, but none of these have been completely therapeutic. Levamisole, an immunomodulator, has been reported to be beneficial in oral mucosal lesions, but there are hardly any studies reported in literature for OSF patients, and hence, the study was taken up. Aim: This study aims to compare the efficacy of levamisole with antioxidant for the assessment of burning sensation and mouth opening in OSF patients. Materials and Methods: A total of 60 patients clinically diagnosed of OSF were selected for the study. We assessed patients for burning sensation and mouth opening. Patients were divided into four groups according to staging of OSF (More et al., classification), then randomly subdivided into three groups to dispense medicines. Group I patients received levamisole, 150 mg once daily for 3 alternate weeks, Group II patients received antioxidant BID for 6 weeks, and Group III patients received levamisole and antioxidant both. The patients were followed up for 2 months. Results and Conclusion: The results proved that levamisole, antioxidant, and the combination of both showed significant improvement in mouth opening and reduction in burning sensation.
背景:口腔黏膜下纤维化(OSF)是一种累及整个口腔黏膜的慢性致残性疾病，主要报道于印度人群。已经尝试了许多治疗方法，但没有一种是完全有效的。左旋咪唑是一种免疫调节剂，据报道对口腔黏膜病变有益，但文献中几乎没有关于OSF患者的研究报道，因此，本研究被采用。目的:比较左旋咪唑与抗氧化剂对OSF患者灼烧感及开口的影响。材料与方法:选择60例临床诊断为OSF的患者进行研究。我们评估了患者的烧灼感和开口。根据OSF分期将患者分为4组(More et al.， classification)，再随机再分为3组配药。组患者给予左旋咪唑150 mg，每日1次，交替3周;组患者给予抗氧化剂BID，连续6周;组患者同时给予左旋咪唑和抗氧化剂。随访2个月。结果与结论:左旋咪唑联合抗氧化剂或两者联合用药均能显著改善大鼠的开口，减轻烧灼感。
{"title":"Comparative evaluation of the efficacy of systemic levamisole and antioxidant in the management of oral submucous fibrosis – A randomized control trial","authors":"Anuja Anil Shinge, Preeti Kanchan-Talreja, D. Das, Amita Navalkar, Prakash S. Talreja, Ashutosh Kakade","doi":"10.15713/INS.JCRI.255","DOIUrl":"https://doi.org/10.15713/INS.JCRI.255","url":null,"abstract":"Background: Oral submucous fibrosis (OSF) is a chronic, disabling disease involving the entire oral mucosa, mainly reported in Indian population. A number of treatment modalities have been tried, but none of these have been completely therapeutic. Levamisole, an immunomodulator, has been reported to be beneficial in oral mucosal lesions, but there are hardly any studies reported in literature for OSF patients, and hence, the study was taken up. Aim: This study aims to compare the efficacy of levamisole with antioxidant for the assessment of burning sensation and mouth opening in OSF patients. Materials and Methods: A total of 60 patients clinically diagnosed of OSF were selected for the study. We assessed patients for burning sensation and mouth opening. Patients were divided into four groups according to staging of OSF (More et al., classification), then randomly subdivided into three groups to dispense medicines. Group I patients received levamisole, 150 mg once daily for 3 alternate weeks, Group II patients received antioxidant BID for 6 weeks, and Group III patients received levamisole and antioxidant both. The patients were followed up for 2 months. Results and Conclusion: The results proved that levamisole, antioxidant, and the combination of both showed significant improvement in mouth opening and reduction in burning sensation.","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89609159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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