C. Bharadwaj, K. B. Varadhan, Prabhuji Munivenkatappa Lakshmaiah Venkatesh, R. Gautam
Background and Objectives: Leptin (Ob) is an obese protein and is known to maintain tissue integrity. Off late, there are reports that leptin aids in dermal wound healing. However, to date, there are no reports on whether leptin has a similar role in periodontal wound healing. Hence, the present study was undertaken to explore whether leptin has a similar role in periodontal wound healing. Materials and Methods: A total of 15 patients (10 males and 5 females) diagnosed as periodontitis were selected who fell under the age range of 30–39 years. The gingival crevicular fluid was collected for leptin analysis from the study group at baseline (who acted as pre-treatment controls), 30th day following non-surgical periodontal therapy (which coincides with the surgical intervention, i.e. open flap periodontal surgery), and at the 3rd day, 14th day, and 35th day following surgical intervention which corresponds to the various phases of periodontal wound healing, acted as post-treatment tests groups. Leptin levels were determined from individual gingival crevicular fluid samples by enzyme-linked immunosorbent assay. Results: There was a little increase in gingival crevicular fluid leptin levels following surgical intervention which was statistically not significant (P > 0.01). One-way analysis of variance and Tukey test were applied for statistical significance. Conclusion: Within the limitations of our study, it can be concluded that there was a little and insignificant raise of leptin at various stages of periodontal wound healing. Hence, it is not clear whether leptin aids in periodontal wound healing and maintains tissue integrity and homeostasis. At the same time, we cannot categorically deny the role of leptin in periodontal wound healing.
{"title":"Investigation of leptin levels in periodontal wound healing: A preliminary study","authors":"C. Bharadwaj, K. B. Varadhan, Prabhuji Munivenkatappa Lakshmaiah Venkatesh, R. Gautam","doi":"10.15713/ins.jcri.264","DOIUrl":"https://doi.org/10.15713/ins.jcri.264","url":null,"abstract":"Background and Objectives: Leptin (Ob) is an obese protein and is known to maintain tissue integrity. Off late, there are reports that leptin aids in dermal wound healing. However, to date, there are no reports on whether leptin has a similar role in periodontal wound healing. Hence, the present study was undertaken to explore whether leptin has a similar role in periodontal wound healing. Materials and Methods: A total of 15 patients (10 males and 5 females) diagnosed as periodontitis were selected who fell under the age range of 30–39 years. The gingival crevicular fluid was collected for leptin analysis from the study group at baseline (who acted as pre-treatment controls), 30th day following non-surgical periodontal therapy (which coincides with the surgical intervention, i.e. open flap periodontal surgery), and at the 3rd day, 14th day, and 35th day following surgical intervention which corresponds to the various phases of periodontal wound healing, acted as post-treatment tests groups. Leptin levels were determined from individual gingival crevicular fluid samples by enzyme-linked immunosorbent assay. Results: There was a little increase in gingival crevicular fluid leptin levels following surgical intervention which was statistically not significant (P > 0.01). One-way analysis of variance and Tukey test were applied for statistical significance. Conclusion: Within the limitations of our study, it can be concluded that there was a little and insignificant raise of leptin at various stages of periodontal wound healing. Hence, it is not clear whether leptin aids in periodontal wound healing and maintains tissue integrity and homeostasis. At the same time, we cannot categorically deny the role of leptin in periodontal wound healing.","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81789424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Orthodontic problems of a cleft lip and palate patient can be associated with soft tissue, skeletal, or dental defects. Some cleft orthodontic problems have a direct relationship to the cleft deformity, whereas others occur secondary to surgery to repair the defects.[1] A small mandible may prevent the downward relocation of the tongue which may mechanically prevent palatal fusion. This is probably the pathogenic mechanism of the cleft palate in the Pierre Robin syndrome characterized by mandibular hypoplasia.[2] This article describes non-surgical management of a repaired cleft palate with transverse arch deficiency and Class II malocclusion in a vertically growing patient, past the active phase of mandibular growth.
{"title":"Catch-up growth after skeletal maturity - A case report","authors":"N. Hridaya, A. Ashok","doi":"10.15713/INS.JCRI.253","DOIUrl":"https://doi.org/10.15713/INS.JCRI.253","url":null,"abstract":"Orthodontic problems of a cleft lip and palate patient can be associated with soft tissue, skeletal, or dental defects. Some cleft orthodontic problems have a direct relationship to the cleft deformity, whereas others occur secondary to surgery to repair the defects.[1] A small mandible may prevent the downward relocation of the tongue which may mechanically prevent palatal fusion. This is probably the pathogenic mechanism of the cleft palate in the Pierre Robin syndrome characterized by mandibular hypoplasia.[2] This article describes non-surgical management of a repaired cleft palate with transverse arch deficiency and Class II malocclusion in a vertically growing patient, past the active phase of mandibular growth.","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"323 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91460351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Rani, Varsha Kanjani, Deepak Kanjani, R. Annigeri
{"title":"Morphometric assessment of mental foramen for gender prediction using panoramic radiographs in the West Bengal population – A retrospective digital study","authors":"A. Rani, Varsha Kanjani, Deepak Kanjani, R. Annigeri","doi":"10.15713/ins.jcri.262","DOIUrl":"https://doi.org/10.15713/ins.jcri.262","url":null,"abstract":"","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79294259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The child with an abdominal mass remains to be a challenging problem for the clinicians. It is more often that apart from parent’s observations that the child is “acting funny” or is “tired,” few symptoms can be elicited. The end result is that the children are brought to the attention of physicians at relatively advanced stages of their diseases. The majority of children who present with abdominal masses do not have surgical disease but rather hepatomegaly due to leukemia or splenomegaly of portal hypertension. In those needing surgical intervention, the majority of masses are retroperitoneal. The retroperitoneum is a unique inaccessible space in the infant and child, wherein all benign and malignant tumors of the kidneys and adrenal glands
{"title":"Characterization of neoplastic and cystic abdominal masses in children, reporting to the government tertiary care center in Vishakhapatnam – A longitudinal, prospective study","authors":"Naga Karthik Garikapatri, Vasanth Dunna, Harini Konakyana, Kameshwari Kolachana","doi":"10.15713/ins.jcri.280","DOIUrl":"https://doi.org/10.15713/ins.jcri.280","url":null,"abstract":"The child with an abdominal mass remains to be a challenging problem for the clinicians. It is more often that apart from parent’s observations that the child is “acting funny” or is “tired,” few symptoms can be elicited. The end result is that the children are brought to the attention of physicians at relatively advanced stages of their diseases. The majority of children who present with abdominal masses do not have surgical disease but rather hepatomegaly due to leukemia or splenomegaly of portal hypertension. In those needing surgical intervention, the majority of masses are retroperitoneal. The retroperitoneum is a unique inaccessible space in the infant and child, wherein all benign and malignant tumors of the kidneys and adrenal glands","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"180 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74957803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Srinivasan, A. Samanta, B. Kumar, M. Madhura, Sarita Yanduri
The immune system is a powerful, complex and diverse defensive mechanism of the body. Any antigenic invasion and infections are well-shielded by these immune cells in a variety of mechanisms. One such advanced procedure being the formation of microabscesses. Microabscess refers to a small accumulation of polymorphs, lymphoid cells, or eosinophils in the epidermis and/or adnexal structures of the skin and epithelium of mucous membranes. A well developed microabscess is composed of a fibrous connective tissue capsule separated from the surrounding tissue, which acts to prevent any microbes contained within the microabscess from further spread. Suppuration and pseudocyst formation can be seen in certain microabscesses. The various types of microabscesses formed are found to contain predominant immune cells, like the neutrophils, lymphocytes, eosinophils and are disease specific. This article attempts to review the microabscesses and unravel their significance in various oral diseases.
{"title":"The tale of microabscesses: A review","authors":"S. Srinivasan, A. Samanta, B. Kumar, M. Madhura, Sarita Yanduri","doi":"10.15713/ins.jcri.286","DOIUrl":"https://doi.org/10.15713/ins.jcri.286","url":null,"abstract":"The immune system is a powerful, complex and diverse defensive mechanism of the body. Any antigenic invasion and infections are well-shielded by these immune cells in a variety of mechanisms. One such advanced procedure being the formation of microabscesses. Microabscess refers to a small accumulation of polymorphs, lymphoid cells, or eosinophils in the epidermis and/or adnexal structures of the skin and epithelium of mucous membranes. A well developed microabscess is composed of a fibrous connective tissue capsule separated from the surrounding tissue, which acts to prevent any microbes contained within the microabscess from further spread. Suppuration and pseudocyst formation can be seen in certain microabscesses. The various types of microabscesses formed are found to contain predominant immune cells, like the neutrophils, lymphocytes, eosinophils and are disease specific. This article attempts to review the microabscesses and unravel their significance in various oral diseases.","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73450587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bhavana T. Veerabasavaiah, T. Nagaraj, N. Ghouse, Leena James
Median rhomboid glossitis (MRG) is well-delineated erythematous area seen in the dorsum aspect of tongue posteriorly along the midline. It is diamond (rhomboid) in shape where the two ends are in anteroposterior direction. The constant contact of MRG to the area of the palate leads to the formation “kissing lesion” or area of erythematous/ roughness patch. Association of candidiasis as oral opportunistic infection is most commonly affecting people whose immune system is compromised due to several etiologies.
{"title":"A concurrent kissing lesion of palate: A case report","authors":"Bhavana T. Veerabasavaiah, T. Nagaraj, N. Ghouse, Leena James","doi":"10.15713/INS.JCRI.260","DOIUrl":"https://doi.org/10.15713/INS.JCRI.260","url":null,"abstract":"Median rhomboid glossitis (MRG) is well-delineated erythematous area seen in the dorsum aspect of tongue posteriorly along the midline. It is diamond (rhomboid) in shape where the two ends are in anteroposterior direction. The constant contact of MRG to the area of the palate leads to the formation “kissing lesion” or area of erythematous/ roughness patch. Association of candidiasis as oral opportunistic infection is most commonly affecting people whose immune system is compromised due to several etiologies.","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84004278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Localized alveolar ridge defect in the partially edentulous maxillary anterior region creates an esthetic challenge for the restorative dentist. The formation of black triangle and residual space at the pontic ridge interface makes the prosthesis esthetically unpleasant and biologically unhealthy. Hence, the surgical correction of localized ridge defect has paramount importance before prosthetic replacement.
{"title":"Surgical correction of alveolar ridge defect with subepithelial connective tissue graft: A Case report","authors":"Renu Gupta, Nitai Debnath, Sumit Banerjee, Vikas Kumar","doi":"10.15713/ins.jcri.268","DOIUrl":"https://doi.org/10.15713/ins.jcri.268","url":null,"abstract":"Localized alveolar ridge defect in the partially edentulous maxillary anterior region creates an esthetic challenge for the restorative dentist. The formation of black triangle and residual space at the pontic ridge interface makes the prosthesis esthetically unpleasant and biologically unhealthy. Hence, the surgical correction of localized ridge defect has paramount importance before prosthetic replacement.","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89019493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Renukaradhya, V. Shilpa, Shwetha Nambiar, R. S. Rao
Journal of Advanced Clinical & Research Insights ● Vol. 6:4 ● Jul-Aug 2019 123 Abstract Stem cell research has been gaining popularity across the globe in recent years with regenerative medicine that is involved in cloning and gene line engineering. The study of stem cell biology requires more human pluripotent and multipotent stem cells. As the stem cell biology varies in humans and mice, human stem cells are required. Citizens should participate in discussing ethical concerns and policy issues regarding stem cell research. There should be specific protocols to enhance production, survival, and integration of transplanted stem cells. This review discusses about the advantages, challenges of stem cell research with strategies to overcome the hurdles.
{"title":"Stem cell research: A new ray of hope","authors":"G. Renukaradhya, V. Shilpa, Shwetha Nambiar, R. S. Rao","doi":"10.15713/ins.jcri.275","DOIUrl":"https://doi.org/10.15713/ins.jcri.275","url":null,"abstract":"Journal of Advanced Clinical & Research Insights ● Vol. 6:4 ● Jul-Aug 2019 123 Abstract Stem cell research has been gaining popularity across the globe in recent years with regenerative medicine that is involved in cloning and gene line engineering. The study of stem cell biology requires more human pluripotent and multipotent stem cells. As the stem cell biology varies in humans and mice, human stem cells are required. Citizens should participate in discussing ethical concerns and policy issues regarding stem cell research. There should be specific protocols to enhance production, survival, and integration of transplanted stem cells. This review discusses about the advantages, challenges of stem cell research with strategies to overcome the hurdles.","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"441 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77512095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Durga Okade, T. Nagaraj, Poonam Sahu, S. Saxena, A. Biswas, Soniya Kongbrailatpam
Oral reticular lichen planus (OLP) is a common mucocutaneous disease of uncertain cause. The disease seems to be autoimmune disease in which the apoptosis is triggered by CD8+T cells and non-specific mechanisms such as activation of matrix metalloproteinase and degranulation of mast cell. It is most often reported in patients with 30–60 years of age, group with a gender predilection, and female-to-male ratio of 1.4:1. This article is a case series of different forms and appearances of OLP with etiopathogenesis, clinical presentation, oral findings, diagnosis, malignant transformation potential, and treatment of OLP.
{"title":"Oral lichen planus: A case series","authors":"Durga Okade, T. Nagaraj, Poonam Sahu, S. Saxena, A. Biswas, Soniya Kongbrailatpam","doi":"10.15713/INS.JCRI.259","DOIUrl":"https://doi.org/10.15713/INS.JCRI.259","url":null,"abstract":"Oral reticular lichen planus (OLP) is a common mucocutaneous disease of uncertain cause. The disease seems to be autoimmune disease in which the apoptosis is triggered by CD8+T cells and non-specific mechanisms such as activation of matrix metalloproteinase and degranulation of mast cell. It is most often reported in patients with 30–60 years of age, group with a gender predilection, and female-to-male ratio of 1.4:1. This article is a case series of different forms and appearances of OLP with etiopathogenesis, clinical presentation, oral findings, diagnosis, malignant transformation potential, and treatment of OLP.","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73768258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Various physiological conditions can bring certain reversible changes in oral health in a women’s lifetime. Conditions such as puberty, pregnancy, and menopause also have a considerable effect on women’s oral health.[1] Moreover, expectant women are susceptible to gingival and periodontal diseases in particular. Pregnant women may not experience symptoms until advanced stages of the disease and therefore, unknowingly experience increased perinatal risk. Premature birth, low birth weight babies, pre-eclampsia, ulcerations of the gingival tissue, pregnancy granuloma, and tooth erosion are few of the associated risks that are involved when there is lack of awareness among expectant mothers.[2-5] Furthermore, practices such as intake of certain drugs such as tetracycline, chloramphenicol, and aspirin and exposure to radiation,[6,7] and practices such as smoking and alcoholism furthermore carry adverse pregnancy outcome or birth defects. Many women fail to understand the importance of oral care in pregnancy, while others experience barriers to care. The period where dental treatment should be taken is also of considerable interest to a pregnant woman and therefore pregnant population poses a unique situation to assess oral health knowledge. Although there is ample literature regarding the oral health status of expecting mothers, insufficient data are available from Indian subcontinent regarding their awareness and motivation of these pregnant women toward the maintenance of good oral hygiene and regular dental check-ups during pregnancy.[8,9] Any educational program can have long-lasting impact on improvising oral health of pregnant women. Thus, a need arises to know the awareness of these patients regarding their motivation toward regular dental check-ups during pregnancy. All members of the health vocation within their scope of duties have the potential to promote oral health by supporting precise oral health-care messages, encouraging regular dental
{"title":"Awareness, attitude, and practices toward maintenance of oral health among pregnant women and oral health awareness and attitude among gynecologists in Hubli and Dharwad","authors":"N. Karkera, K. Guttal, K. Burde, K. Nandimath","doi":"10.15713/ins.jcri.270","DOIUrl":"https://doi.org/10.15713/ins.jcri.270","url":null,"abstract":"Various physiological conditions can bring certain reversible changes in oral health in a women’s lifetime. Conditions such as puberty, pregnancy, and menopause also have a considerable effect on women’s oral health.[1] Moreover, expectant women are susceptible to gingival and periodontal diseases in particular. Pregnant women may not experience symptoms until advanced stages of the disease and therefore, unknowingly experience increased perinatal risk. Premature birth, low birth weight babies, pre-eclampsia, ulcerations of the gingival tissue, pregnancy granuloma, and tooth erosion are few of the associated risks that are involved when there is lack of awareness among expectant mothers.[2-5] Furthermore, practices such as intake of certain drugs such as tetracycline, chloramphenicol, and aspirin and exposure to radiation,[6,7] and practices such as smoking and alcoholism furthermore carry adverse pregnancy outcome or birth defects. Many women fail to understand the importance of oral care in pregnancy, while others experience barriers to care. The period where dental treatment should be taken is also of considerable interest to a pregnant woman and therefore pregnant population poses a unique situation to assess oral health knowledge. Although there is ample literature regarding the oral health status of expecting mothers, insufficient data are available from Indian subcontinent regarding their awareness and motivation of these pregnant women toward the maintenance of good oral hygiene and regular dental check-ups during pregnancy.[8,9] Any educational program can have long-lasting impact on improvising oral health of pregnant women. Thus, a need arises to know the awareness of these patients regarding their motivation toward regular dental check-ups during pregnancy. All members of the health vocation within their scope of duties have the potential to promote oral health by supporting precise oral health-care messages, encouraging regular dental","PeriodicalId":14943,"journal":{"name":"Journal of Advanced Clinical and Research Insights","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85394739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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