Journal of Biochemical Technology最新文献

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Effectiveness of the Use of Citrulline Malate to Increase the Powerlifters Adaptive Potential and Physical Performance 使用瓜氨酸苹果酸提高举重运动员适应潜能和体能的有效性

IF 0.5

Journal of Biochemical Technology

Pub Date : 2023-01-01 DOI: 10.51847/gd16a1jnmz

A. Tishchenko, Diana Aleksandrovna Kaplanyan, Viktoriya Andreevna Krechetova, Yaramir Khadzhiretovich Frantsuzov, Islam Shamilovich Shakhbanov, Anita Varuzhanovna Chnavayan

引用次数: 0

Metformin Anti-Tumor Effect and Metabolic Reprogramming in Breast Cancer Cells 二甲双胍在乳腺癌细胞中的抗肿瘤作用和代谢重编程

IF 0.5

Journal of Biochemical Technology

Pub Date : 2023-01-01 DOI: 10.51847/u62zz2npvj

Feryal Alharthy, A. Alamoudi, Amina Alnouri, Arwa Alkhuzaee, G. Ajabnoor, Mehal A AlQriqri, H. Gad, H. Choudhry, A. Aldahlawi, R. R. Basheer

引用次数: 0

The State Biology Museum Named after Kliment Arkadyevich Timiryazev as a Scientific and Educational Center 国家生物博物馆以Kliment Arkadyevich Timiryazev命名，作为科学和教育中心

IF 0.5

Journal of Biochemical Technology

Pub Date : 2023-01-01 DOI: 10.51847/olkerwxo55

Michail A. Osadchuk, A. Osadchuk, Inna Vasilieva, M. Trushin

引用次数: 0

Treatment of Menstruation Disorders at Puberty: A Plant-Based Dietary Supplement Efficacy and Safety 青春期月经紊乱的治疗:植物性膳食补充剂的有效性和安全性

Journal of Biochemical Technology

Pub Date : 2023-01-01 DOI: 10.51847/r9vjre0mhw

Valery Petrovich Sergun, Bereslavets Evgenia, Valentina Nikolaevna Burkova, Valeriy Mikhailovich Poznyakovsky, Nadezhda Nikolaevna Danko, Boisjoni Tokhiriyon

Primary dysmenorrhea harms the physical and social functioning of many young women. At the Siberian State Medical University laboratory complex and Tomsk prenatal clinic No. 4 antenatal clinic, a clinical experiment was conducted to better understand the impact of diet on the treatment of menstrual problems. In the clinical experiment, sixty young women with dysmenorrhea between the ages of 14 and 18 took part. To assess the efficacy of complex treatment both objective and subjective performance criteria were used. All the participants underwent numerous examinations before the trial, and the whole process of the treatment was carefully recorded and analyzed. The supplement was prescribed to complement the conventional cyclic vitamin therapy. The tested dietary supplement demonstrated bacterial, anti-inflammatory, and immune-stimulating effects. The favorable impact of the supplement on the autonomic nervous system was registered. The participants of the experimental group experienced pain relief and demonstrated a noticeable improvement. No side effects were detected during the clinical trial.

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引用次数: 0

The Role of Food Biochemistry in The Control and Prevention of Nervous System Diseases 食品生物化学在控制和预防神经系统疾病中的作用

Journal of Biochemical Technology

Pub Date : 2023-01-01 DOI: 10.51847/atdejs15py

Florica Voiţă-Mekereş, Felicia Manole, Ioan Bogdan Voiţă, Paula Marian

引用次数: 0

Arterial Hypertension in Ukraine: Medical and Social Problems of Pathogenesis 乌克兰动脉高血压:发病机制的医学和社会问题

IF 0.5

Journal of Biochemical Technology

Pub Date : 2023-01-01 DOI: 10.51847/uhbo9d7zip

N. Korylchuk, R. Riabushko, I. Haman, Anatolija Krasnova, N. Dovzhuk

Arterial hypertension is becoming increasingly common among diseases of the cardiovascular system. The work aimed to analyze blood pressure control in patients diagnosed with arterial hypertension. Fifty physicians and 1020 patients (under 56 years of age) participated in the study. Regular use of medications was observed in 92% of the patients, and the systolic blood pressure level was 167 mm Hg. More frequent use of renin-angiotensin system blockers compared with diuretics and calcium antagonists was noted, both in monotherapy and in combination therapy. Target BP was achieved in 66% of cases within three months by therapy with amlodipine and retarded indapamide. The majority of patients adhered to the prescribed therapy (97%). The effectiveness of amlodipine and indapamide therapy was in direct correlation with baseline BP values. Significant factors were smoking (lower efficacy), and gender (higher in women). The degree of BP reduction following combined therapy with amlodipine and indapamide was determined to be directly correlated with the beginning BP level. At the same time, female patients and non-smokers see more pronounced dynamics of BP lowering. Pre-treatment is also a crucial element; statins and renin system blockers greatly lower blood pressure when used together.

动脉高血压在心血管系统疾病中越来越常见。这项工作旨在分析被诊断为动脉高血压的患者的血压控制。50名医生和1020名患者(56岁以下)参与了这项研究。92%的患者定期使用药物，收缩压水平为167毫米汞柱。与利尿剂和钙拮抗剂相比，在单药和联合治疗中，肾素-血管紧张素系统阻滞剂的使用频率更高。66%的病例在3个月内通过氨氯地平和迟发性吲达帕胺治疗达到目标血压。大多数患者坚持处方治疗(97%)。氨氯地平和吲达帕胺治疗的有效性与基线血压值直接相关。显著因素为吸烟(低疗效)和性别(女性高疗效)。确定氨氯地平与吲达帕胺联合治疗后的血压降低程度与初始血压水平直接相关。与此同时，女性患者和非吸烟者的血压下降趋势更为明显。预处理也是一个关键因素;他汀类药物和肾素系统阻滞剂一起使用时，可大大降低血压。

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引用次数: 0

Antibiotics Coupled with Photothermal Therapy for the Enhanced Killing of Bacteria. 抗生素与光热疗法相结合，增强杀灭细菌的效果。

IF 0.5

Journal of Biochemical Technology

Pub Date : 2023-01-01 Epub Date: 2023-09-26 DOI: 10.51847/nplvoycg9u

Amanda Jalihal, Armin Mortazi, Mavis Forson, Mujeebat Bashiru, Thuy Le, Adeniyi Oyebade, Noureen Siraj

In this study, the application of ionic materials as a combination antibiotic drug was investigated. The fluoroquinolone, Norfloxacin, was converted into the ionic form and combined with the cationic dye, IR780⁺, using an ion-exchange reaction. The resulting ionic combination drug possesses two killing mechanisms in one compound. The antibiotic chemical mechanism along with the photothermal mechanism that was acquired by adding IR780 to the compound led to the development of a combination antibiotic drug. This ionic combination drug consisting of Norfloxacin anion and IR780 cation is easily dispersed in water using sonication waves. The parent compounds and ionic combination drug, dissolved in organic solvent and dispersed in water, were characterized, and the photophysical properties were studied in detail. It was discovered that the aqueous ionic combination drugs exhibited significant changes in absorbance and photoluminescent properties. In aqueous media, the dispersed ionic combination drug exhibited a very broad absorbance with an additional peak around 1000 nm which is advantageous in photothermal. A significant decrease in the quantum yield along with enhanced non-radiative rate constant was observed for the combination drug in the aqueous. The photothermal mechanism is present in both the parent IR780 dye and the ionic combination drug. The ionic combination drug displayed a high light-to-heat conversion efficiency and temperature increase similar to the parent dye. The combination of both killing mechanisms in the ionic combination drug resulted in enhanced antibacterial activity against Escherichia coli as compared to the parent Norfloxacin and IR780-I individually.

本研究探讨了离子材料作为复合抗生素药物的应用。利用离子交换反应将氟喹诺酮诺氟沙星转化为离子形式，并与阳离子染料 IR780+ 结合。由此产生的离子组合药物在一个化合物中具有两种杀菌机制。抗生素化学机制以及通过在化合物中添加 IR780 而获得的光热机制，促成了抗生素复方药物的开发。这种由诺氟沙星阴离子和 IR780 阳离子组成的离子组合药物很容易通过超声波分散在水中。研究人员对溶解在有机溶剂中并分散在水中的母体化合物和离子组合药物进行了表征，并详细研究了其光物理性质。研究发现，水性离子组合药物的吸光度和光致发光特性发生了显著变化。在水介质中，分散的离子组合药物表现出非常宽的吸光度，并在 1000 纳米附近出现一个额外的峰值，这在光热方面具有优势。在水介质中，组合药物的量子产率明显下降，非辐射速率常数增强。母体 IR780 染料和离子组合药物都存在光热机制。离子组合药物显示出较高的光热转换效率，温度升高与母体染料相似。与母体诺氟沙星和 IR780-I 相比，离子组合药物中两种杀菌机制的结合增强了对大肠杆菌的抗菌活性。

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引用次数: 0

Study of Blood-Ocular Barrier Permeability by Levomecitin Group Drugs in Normal and Pathological Conditions 左旋美西丁组药物对正常和病理血眼屏障通透性的影响

IF 0.5

Journal of Biochemical Technology

Pub Date : 2023-01-01 DOI: 10.51847/dwoixyzfkz

Daria Andreevna Gorokhova, Karolina Karenovna Tsaturyan, Albert Armenovich Engibaryan, Valeriia Fedorovna Bosenko, N. V. Makarenko, Anna Vladimirovna Chernookova

An eye defense mechanism called the blood-ocular barrier stops hazardous compounds from the circulatory system from entering the eye's structural components. In order to preserve human health and quality of life, the blood-ocular barrier must operate at its peak. There are several eye illnesses that might be linked to a breach in the blood-ocular barrier's functionality. The blood-ocular barrier's permeability to medications in the levomecitin group was examined in this paper under both healthy and unhealthy circumstances. A total of 40 laboratory rabbits were divided into two groups for this reason, and the experimental group's rabbits underwent artificial induction of keratoconjunctivitis. In the posterior femoral muscle group of rabbits in the control and experimental groups, a 30 mg/kg dose of a 10% chloramphenicol solution diluted in a 0.5% novocaine solution was intramuscularly administered twice, separated by a 12-hour interval. Next, the behavior and health of the rabbits in both groups were observed, along with routine checks on the animals' body temperatures, pulses, and respirations. On several experiment days, the level of chloramphenicol in blood serum and intraocular fluid was examined in order to gauge the permeability of the blood-ocular barrier. Further research was done on the biochemical and hematological characteristics of blood serum.

一种叫做血眼屏障的眼睛防御机制可以阻止循环系统中的有害化合物进入眼睛的结构成分。为了维护人类健康和生活质量，血眼屏障必须在其最高水平上运作。有几种眼病可能与血眼屏障功能的破坏有关。在健康和不健康两种情况下，研究了左旋霉素组血眼屏障对药物的渗透性。为此将40只实验兔分为两组，实验组兔进行角膜结膜炎人工诱导。对照组和实验组兔股后肌组，以0.5%奴佛卡因溶液稀释10%氯霉素溶液30 mg/kg的剂量肌内给药2次，间隔12小时。接下来，研究人员观察了两组兔子的行为和健康状况，并对动物的体温、脉搏和呼吸进行了常规检查。在数天的实验中，检测了血清和眼内液中氯霉素的水平，以测量血眼屏障的通透性。进一步研究了血清的生化和血液学特性。

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引用次数: 0

Applications of Deep Learning and Machine Learning in Computational Medicine 深度学习和机器学习在计算医学中的应用

IF 0.5

Journal of Biochemical Technology

Pub Date : 2023-01-01 DOI: 10.51847/iw1dfvoxvw

R. Adiga, Titas Biswas, P. Shyam

Computational medicine has emerged due to the advances in medical technology in parallel with big data and artificial intelligence. A new way of treating complex diseases is evolving called 'Precision Medicine' fueled by big data extracting meaningful information from individual variability. At the forefront is biomedical research aiming to promote the area of precision medicine. Though traditional machine learning methods have built successful models for cancer diagnosis to sars-cov2 pulmonary infection, the advent of modern deep learning methods has had phenomenal growth in genomics, electronic health records, and drug development. The challenges in Deep learning applications in medicine include lack of data, privacy, heterogeneity of data, and interpretability. Analysis and discussion on these problems provide a reference to improve the application of deep learning in medical health.

由于医疗技术的进步，与大数据和人工智能并行，计算医学应运而生。一种治疗复杂疾病的新方法正在发展，被称为“精准医学”，它由大数据推动，从个体差异中提取有意义的信息。最前沿的是旨在促进精准医疗领域的生物医学研究。虽然传统的机器学习方法已经成功地建立了癌症诊断到sars-cov2肺部感染的模型，但现代深度学习方法的出现在基因组学、电子健康记录和药物开发方面取得了惊人的增长。深度学习在医学中的应用面临的挑战包括缺乏数据、隐私、数据的异质性和可解释性。对这些问题进行分析和探讨，为进一步完善深度学习在医疗健康领域的应用提供参考。

引用次数: 1

Plant Biotechnology Potential for Food Production: The Tyumen Region 植物生物技术在粮食生产中的潜力:秋明地区

Journal of Biochemical Technology

Pub Date : 2023-01-01 DOI: 10.51847/hsrseyplwa

Marina Viktorovna Nikolenko, Vera Viktorovna Trigub, Vladimir Grigorievich Popov, Elena Viktorovna Ragozinnikova, Galina Georgievna Cherentsova, Boisjoni Tokhiriyon

引用次数: 0

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