Journal of biomechanics最新文献_第10页

Differences between two maximal principal strain rate calculation schemes in traumatic brain analysis with in-vivo and in-silico datasets 利用体内和实验室数据集分析脑外伤时两种最大主应变率计算方法的差异。

IF 2.4 3区医学 Q3 BIOPHYSICS

Journal of biomechanics

Pub Date : 2025-01-01 DOI: 10.1016/j.jbiomech.2024.112456

Xianghao Zhan , Zhou Zhou , Yuzhe Liu , Nicholas J. Cecchi , Marzieh Hajiahamemar , Michael M. Zeineh , Gerald A. Grant , David Camarillo

Brain deformation caused by a head impact leads to traumatic brain injury (TBI). The maximum principal strain (MPS) was used to measure the extent of brain deformation and predict injury, and the recent evidence has indicated that incorporating the maximum principal strain rate (MPSR) and the product of MPS and MPSR, denoted as MPS × SR, enhances the accuracy of TBI prediction. However, ambiguities have arisen about the calculation of MPSR. Two schemes have been utilized: one is to use the time derivative of MPS (MPSR₁), and another is to use the first eigenvalue of the strain rate tensor (MPSR₂). Both MPSR₁ and MPSR₂ have been applied in previous studies to predict TBI. To quantify the discrepancies between these two methodologies, we compared them across eight in-vivo and one in-silico head impact datasets and found that 95MPSR₁ was slightly larger than 95MPSR₂ and 95MPS × SR₁ was 4.85 % larger than 95MPS × SR₂ in average. Across every element in all head impacts, the average MPSR₁ was 12.73 % smaller than MPSR₂, and MPS × SR₁ was 11.95 % smaller than MPS × SR₂. Furthermore, logistic regression models were trained to predict TBI using MPSR (or MPS × SR), and no significant difference was observed in the predictability. The consequence of misuse of MPSR and MPS × SR thresholds (i.e. compare threshold of 95MPSR₁ with value from 95MPSR₂ to determine if the impact is injurious) was investigated, and the resulting false rates were found to be around 1 %. The evidence suggested that these two methodologies were not significantly different in detecting TBI.

头部撞击造成的脑变形会导致创伤性脑损伤（TBI）。最大主应变（MPS）被用来测量脑变形的程度和预测损伤，最近的证据表明，将最大主应变率（MPSR）以及 MPS 和 MPSR 的乘积（表示为 MPS × SR）结合起来可提高 TBI 预测的准确性。然而，在计算 MPSR 时出现了一些模糊之处。目前有两种方案：一种是使用 MPS 的时间导数（MPSR1），另一种是使用应变速率张量的第一个特征值（MPSR2）。在以往的研究中，MPSR1 和 MPSR2 都被用于预测创伤性脑损伤。为了量化这两种方法之间的差异，我们在八个体内头部撞击数据集和一个模拟头部撞击数据集中对其进行了比较，发现 95MPSR1 略大于 95MPSR2，95MPS × SR1 平均比 95MPS × SR2 大 4.85%。在所有头部撞击的每个元素中，平均 MPSR1 比 MPSR2 小 12.73%，MPS × SR1 比 MPS × SR2 小 11.95%。此外，利用 MPSR（或 MPS × SR）训练了逻辑回归模型来预测创伤性脑损伤，在预测性方面没有观察到显著差异。对误用 MPSR 和 MPS × SR 临界值（即比较 95MPSR1 临界值和 95MPSR2 临界值以确定撞击是否具有伤害性）的后果进行了调查，结果发现误差率约为 1%。证据表明，这两种方法在检测创伤性脑损伤方面没有明显差异。

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引用次数: 0

Kinematics of abdominal aortic Aneurysms 腹主动脉瘤的运动学。

IF 2.4 3区医学 Q3 BIOPHYSICS

Journal of biomechanics

Pub Date : 2025-01-01 DOI: 10.1016/j.jbiomech.2024.112484

Mostafa Jamshidian, Adam Wittek, Saeideh Sekhavat, Karol Miller

A search in Scopus within “Article title, Abstract, Keywords” unveils 2,444 documents focused on the biomechanics of Abdominal Aortic Aneurysm (AAA), mostly on AAA wall stress. Only 24 documents investigated AAA kinematics, an important topic that could potentially offer significant insights into the biomechanics of AAA. In this paper, we present an image-based approach for patient-specific, in vivo, and non-invasive AAA kinematic analysis using patient’s time-resolved 3D computed tomography angiography (4D-CTA) images, with an objective to measure wall displacement and strain during the cardiac cycle. Our approach relies on regularized deformable image registration for estimating wall displacement, estimation of the local wall strain as the ratio of its normal displacement to its local radius of curvature, and local surface fitting with non-deterministic outlier detection for estimating the wall radius of curvature. We verified our approach against synthetic ground truth image data created by warping a 3D-CTA image of AAA using a realistic displacement field obtained from a finite element biomechanical model. We applied our approach to assess AAA wall displacements and strains in ten patients. Our kinematic analysis results indicated that the 99th percentile of circumferential wall strain, among all patients, ranged from 2.62% to 5.54%, with an average of 4.45% and a standard deviation of 0.87%. We also observed that AAA wall strains are significantly lower than those of a healthy aorta. Our work demonstrates that the registration-based measurement of AAA wall displacements in the direction normal to the wall is sufficiently accurate to reliably estimate strain from these displacements.

在Scopus中搜索“文章标题，摘要，关键词”，可以找到2444篇关于腹主动脉瘤（AAA）生物力学的文献，其中大部分是关于AAA壁应力的。只有24篇文献研究了AAA的运动学，这是一个重要的主题，可能为AAA的生物力学提供重要的见解。在本文中，我们提出了一种基于图像的方法，用于患者特异性的、体内的、无创的AAA运动学分析，使用患者的时间分辨3D计算机断层血管造影（4D-CTA）图像，目的是测量心脏周期期间的壁位移和应变。我们的方法依赖于正则化的可变形图像配准来估计壁面位移，估计局部壁面应变作为其法向位移与局部曲率半径的比值，以及使用非确定性离群检测的局部表面拟合来估计壁面曲率半径。我们通过使用从有限元生物力学模型中获得的真实位移场对AAA的3D-CTA图像进行扭曲而生成的合成地面真实图像数据验证了我们的方法。我们应用我们的方法评估了10例患者的AAA壁位移和应变。我们的运动学分析结果显示，所有患者圆周壁应变的第99百分位范围为2.62% ~ 5.54%，平均值为4.45%，标准差为0.87%。我们还观察到，AAA的壁应变明显低于健康主动脉。我们的工作表明，基于配准的AAA墙在与墙垂直方向上的位移测量足够准确，可以可靠地估计这些位移的应变。

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引用次数: 0

End-divergent architecture diversifies within-muscle mechanical action in human gluteus maximus in vivo 人体臀大肌的末端分化结构在体内使肌肉内的机械作用多样化。

IF 2.4 3区医学 Q3 BIOPHYSICS

Journal of biomechanics

Pub Date : 2025-01-01 DOI: 10.1016/j.jbiomech.2024.112488

Katsuki Takahashi , Raki Kawama , Taku Wakahara

A muscle’s mechanical action is affected by its architecture. However, less is known about the architecture of muscles with broad attachments: “end-divergent” muscles. Potential regional variation of fascicle orientation in end-divergent muscles suggests that their mechanical action varies by region. Here, we comprehensively examined 3D architecture and potential action of the human gluteus maximus (typical end-divergent muscle) in vivo. The gluteus maximus fascicles were three-dimensionally reconstructed over the whole muscle belly using diffusion tensor imaging and tractography. We calculated the force fraction and moment-arm length about the hip joint for individual muscle fascicles, and their product (specific torque, an estimate of torque-generating capacity for a given cross-sectional area). We found that the specific torque for hip extension and external rotation tended to be greater in the distal than the other regions, whereas that for hip abduction appeared to be greater in the proximal than the other regions. Notably, the distal-lateral region exhibited a negative specific torque for hip abduction, indicating that fascicles in this region act for hip “adduction”. These findings indicate that end-divergent architecture diversifies within-muscle mechanical action in terms of directions as well as magnitudes in vivo.

肌肉的机械作用受其结构的影响。然而，对具有广泛附着物的肌肉结构知之甚少：“末端发散”肌肉。末端发散肌束取向的潜在区域变化表明它们的机械作用因区域而异。在这里，我们全面检查了人体臀大肌（典型的终发散肌）的三维结构和潜在作用。利用弥散张量成像和肌束造影对整个肌腹的臀大肌束进行三维重建。我们计算了髋关节各个肌肉束的力分数和力矩臂长，以及它们的乘积（特定扭矩，对给定横截面积的扭矩产生能力的估计）。我们发现髋外展和髋外旋的特定扭矩在远端大于其他区域，而髋外展的特定扭矩在近端大于其他区域。值得注意的是，远侧区域对髋关节外展表现出负的比扭矩，表明该区域的肌束参与髋关节内收。这些发现表明，就方向和体内大小而言，末端分化结构在肌肉机械作用中多样化。

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引用次数: 0

Biomechanical differences and variability during sustained motorized treadmill running versus outdoor overground running using wearable sensors 与使用可穿戴传感器的户外地面跑步相比，持续电动跑步机跑步的生物力学差异和可变性。

IF 2.4 3区医学 Q3 BIOPHYSICS

Journal of biomechanics

Pub Date : 2025-01-01 DOI: 10.1016/j.jbiomech.2024.112443

Alexandra F. DeJong Lempke , Adam P. Audet , Marni G. Wasserman , Amanda C. Melvin , Katherine Soldes , Ella Heithoff , Sneh Shah , Kenneth M. Kozloff , Adam S. Lepley

This study aimed to compare running biomechanics and biomechanical variability across 3 run segments and between conditions for 5-km outdoor overground and indoor treadmill running. Seventy-one recreationally-active adults (31F, 40 M; age: 37 ± 11 years; body mass index: 22.9 ± 2.5 kg/m²) completed aerobic fitness assessments at baseline (VO₂max), outdoor overground 5 km runs on a standardized route, and indoor treadmill 5 km runs on a motorized system (12.6 ± 4.9 days apart). Wearable sensors recorded step-by-step spatiotemporal, kinetic, and kinematic biomechanics. Repeated measures analyses of covariance were used to compare mean and coefficient of variation (CV) of sensor-derived metrics across run segments, conditions, and limbs (covariates: pace, VO₂max). Tukey’s post-hoc tests with mean differences and Cohen’s d effect sizes were used to determine the difference magnitudes across comparisons. Most biomechanical measures significantly differed between running conditions (p < 0.001); contact time (mean difference and standard error: 8 ± 3 ms; d = 0.20), stride length (0.20 ± 0.12 m; d: 0.31), kinetics (shock, impact, braking; 0.17–1.30 g; d-range: 0.36–0.57), and pronation velocity (138 ± 16°/s; d: 0.61) were all higher during indoor treadmill running. Indoor treadmill running biomechanics CV were significantly higher for most measures compared to outdoor overground running (p < 0.001; d-range: 0.18–0.52). Only spatiotemporal measures and CV significantly differed across run segments (d-range: 0.16–0.68). Clinicians should expect that indoor treadmill biomechanics, particularly kinetic and pronation, will be significantly higher than patients’ outdoor overground running biomechanics and tailor subsequent recommendations accordingly. Furthermore, clinicians should expect that indoor treadmill running analyses may result in more variable biomechanics, potentially attributed to consistent speed and surface, and tailor assessments to preferred run environments.

本研究旨在比较3个跑步段的跑步生物力学和生物力学变异性，以及5公里户外地面和室内跑步机跑步条件之间的差异。71名从事娱乐活动的成年人(31岁，40岁；年龄：37±11岁；身体质量指数：22.9±2.5 kg/m2)完成基线有氧体能评估（VO2max）、标准化路线室外地上5公里跑和电动系统室内跑步机5公里跑（间隔12.6±4.9天）。可穿戴传感器记录一步一步的时空、动力学和运动学生物力学。使用协方差的重复测量分析来比较传感器衍生指标在跑步段、条件和肢体上的平均值和变异系数（CV）（协变量：步速、最大摄氧量）。使用Tukey的平均差异事后检验和Cohen效应量来确定比较之间的差异幅度。大多数生物力学指标在不同的跑步条件下有显著差异(p

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引用次数: 0

A review of computational methodologies to predict the fractional flow reserve in coronary arteries with stenosis 预测冠状动脉狭窄部位部分血流储备的计算方法综述。

IF 2.4 3区医学 Q3 BIOPHYSICS

Journal of biomechanics

Pub Date : 2025-01-01 DOI: 10.1016/j.jbiomech.2024.112299

M. Fernandes , L.C. Sousa , C.C. António , S. Silva , S.I.S. Pinto

Computational methodologies for predicting the fractional flow reserve (FFR) in coronary arteries with stenosis have gained significant attention due to their potential impact on healthcare outcomes. Coronary artery disease is a leading cause of mortality worldwide, prompting the need for accurate diagnostic and treatment approaches. The use of medical image-based anatomical vascular geometries in computational fluid dynamics (CFD) simulations to evaluate the hemodynamics has emerged as a promising tool in the medical field. This comprehensive review aims to explore the state-of-the-art computational methodologies focusing on the possible considerations. Key aspects include the rheology of blood, boundary conditions, fluid–structure interaction (FSI) between blood and the arterial wall, and multiscale modelling (MM) of stenosis. Through an in-depth analysis of the literature, the goal is to obtain an overview of the major achievements regarding non-invasive methods to compute FFR and to identify existing gaps and challenges that inform further advances in the field. This research has the major objective of improving the current diagnostic capabilities and enhancing patient care in the context of cardiovascular diseases.

用于预测冠状动脉狭窄部位部分血流储备（FFR）的计算方法因其对医疗效果的潜在影响而备受关注。冠状动脉疾病是全球死亡的主要原因，因此需要准确的诊断和治疗方法。在计算流体动力学（CFD）模拟中使用基于医学影像的解剖血管几何图形来评估血液动力学，已成为医学领域一种前景广阔的工具。本综述旨在探讨最先进的计算方法，重点关注可能的考虑因素。主要方面包括血液流变学、边界条件、血液与动脉壁之间的流固相互作用（FSI）以及狭窄的多尺度建模（MM）。通过对文献的深入分析，目的是了解计算 FFR 的无创方法的主要成就，并找出现有的差距和挑战，为该领域的进一步发展提供参考。这项研究的主要目的是提高当前的诊断能力，加强对心血管疾病患者的护理。

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引用次数: 0

Integration of cross-links, discrete fiber distributions and of a non-local theory in the Homogenized Constrained Mixture Model to Simulate Patient-Specific Thoracic Aortic Aneurysm Progression 将交联、离散纤维分布和非局部理论整合到同质化约束混合物模型中，以模拟特定患者的胸主动脉瘤进展。

IF 2.4 3区医学 Q3 BIOPHYSICS

Journal of biomechanics

Pub Date : 2025-01-01 DOI: 10.1016/j.jbiomech.2024.112297

Felipe Sempértegui, Stéphane Avril

Thoracic aortic aneurysms (TAA) represent a critical health issue for which computational models can significantly contribute to better understand the physiopathology. Among different computational frameworks, the Homogenized Constrained Mixture Theory has shown to be a computationally efficient option, allowing the inclusion of several mechanically significant constituents into a layer-specific mixture. Different patient-specific Growth and Remodeling (G&R) models correctly predicted TAA progression, although simplifications such as the inclusion of a limited number of collagen fibers and imposed boundary conditions might limit extensive analyses. The current study aims to enhance existing models by incorporating several discrete collagen fibers and to remove restrictive boundary conditions of the previous models. The implementation of discretized fiber dispersion presents a more realistic description of the vessel, while the removal of boundary conditions was addressed by including cross-links in the model to provide a supplemental stiffness against through-thickness shearing, a feature that was previously absent, and by the development of a non-local framework that ensures the stable deposition and degradation of collagen fibers. With these improvements, the current model represents a step forward towards more robust and comprehensive simulations of TAA growth.

胸主动脉瘤（TAA）是一个重要的健康问题，而计算模型可以为更好地了解其生理病理做出重大贡献。在不同的计算框架中，均质化约束混合物理论（Homogenized Constrained Mixture Theory）已被证明是一种计算高效的选择，它允许将几种具有重要力学意义的成分纳入特定层的混合物中。不同的患者特异性生长与重塑（G&R）模型能正确预测 TAA 的进展，尽管简化了模型，如纳入有限数量的胶原纤维和施加边界条件可能会限制广泛的分析。目前的研究旨在通过纳入几种离散胶原纤维来增强现有模型，并消除以前模型的限制性边界条件。离散纤维分散的实施能更真实地描述血管，而去除边界条件的方法是在模型中加入交联，以提供对抗通厚剪切的补充刚度（这是以前没有的特征），并开发一个非局部框架，确保胶原纤维的稳定沉积和降解。通过这些改进，目前的模型向着更强大、更全面的 TAA 生长模拟迈进了一步。

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引用次数: 0

The hemodynamic responses to enhanced external counterpulsation therapy in post-PCI patients with a multi-dimension 0/1D-3D model 基于多维0/1D-3D模型的pci术后患者强化体外反搏治疗的血流动力学反应

IF 2.4 3区医学 Q3 BIOPHYSICS

Journal of biomechanics

Pub Date : 2025-01-01 DOI: 10.1016/j.jbiomech.2024.112487

Xuan-hao Xu , Zhi-bo Wang , Qi Zhang , Jie-ting Wang , Xue Jia , Li-ling Hao , Ling Lin , Gui-fu Wu , Shuai Tian

Enhanced external counterpulsation (EECP) is widely utilized in rehabilitating patients after percutaneous coronary intervention (PCI) and has demonstrated efficacy in promoting cardiovascular function recovery. Although the precise mechanisms of the therapeutic effects remain elusive, it is widely postulated that the improvement of biomechanical environment induced by EECP plays a critical role. This study aimed to unravel the underlying mechanism through a numerical investigation of the in-stent biomechanical environment during EECP using an advanced multi-dimensional 0/1D-3D coupled model. Physiological data, including age, height, coronary angiography images, and blood velocity profiles of five different arteries, were clinically collected from eleven volunteers both at rest and during EECP. These data contributed the development of a patient-specific 0/1D model to predict the coronary volumetric flow and a 3D stented coronary artery model to capture the detailed in-stent biomechanical features. Specifically, an immersed solid method was introduced to address the numerical challenges of generating computational cells for the 3D model. Simulations revealed that EECP significantly improved the biomechanical environment within the stented arteries, as evidenced by increased time-averaged wall shear stress (resting vs. 20 kPa vs. 30 kPa: 1.39 ± 0.4773 Pa vs. 1.82 ± 0.6856 Pa vs. 1.96 ± 0.7592 Pa, p = 0.0009) and reduced relative residence time (resting vs. 20 kPa vs. 30 kPa: 1.06 ± 0.3926 Pa⁻¹ vs. 0.89 ± 0.3519 Pa⁻¹ vs. 0.87 ± 0.3764 Pa⁻¹, p < 0.0001). Correspondingly, low-WSS/high-RRT surfaces were obviously reduced under EECP. These findings provide deeper insights into EECP’s therapeutic mechanisms, thereby offering basis to optimize EECP protocols for enhanced clinical outcomes in post-PCI patients.

体外强化反搏（EECP）在经皮冠状动脉介入治疗（PCI）后的患者康复中被广泛应用，并已证明其促进心血管功能恢复的疗效。虽然治疗效果的确切机制尚不清楚，但人们普遍认为EECP诱导的生物力学环境的改善起着关键作用。本研究旨在通过使用先进的多维0/1D-3D耦合模型对EECP期间支架内生物力学环境进行数值研究，揭示其潜在机制。生理数据，包括年龄、身高、冠状动脉造影图像和5条不同动脉的血流速度分布，临床收集了11名志愿者在休息和EECP期间的数据。这些数据有助于开发患者特异性的0/1D模型来预测冠状动脉容量流量，以及3D支架冠状动脉模型来捕获支架内详细的生物力学特征。具体而言，引入了一种浸入固体方法来解决生成三维模型计算单元的数值挑战。模拟结果显示，EECP显著改善了支架动脉内的生物力学环境，增加了时间平均壁剪切应力（静息与20 kPa vs 30 kPa: 1.39±0.4773 Pa vs 1.82±0.6856 Pa vs 1.96±0.7592 Pa, p = 0.0009），减少了相对停留时间（静息与20 kPa vs 30 kPa: 1.06±0.3926 Pa-1 vs 0.89±0.3519 Pa-1 vs 0.87±0.3764 Pa-1, p = 0.0009）

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引用次数: 0

A novel load-sensing sliding hip screw to aid in the assessment of intertrochanteric fracture healing 新型负荷传感滑动髋关节螺钉可帮助评估转子间骨折愈合情况。

IF 2.4 3区医学 Q3 BIOPHYSICS

Journal of biomechanics

Pub Date : 2025-01-01 DOI: 10.1016/j.jbiomech.2024.112481

Nathan T. Carrington , Paul W. Milhouse , Caleb J. Behrend , Savannah R. Forrester , Thomas B. Pace , Jeffrey N. Anker , John D. DesJardins

Bone healing after sliding hip screw internal fixation of intertrochanteric hip fractures is difficult to monitor with radiography. In this study, we describe and evaluate a device to non-invasively determine the loading on the screw implant as a possible qualitative indicator of bone healing. A novel load-sensing sliding hip screw (LS-SHS) was fabricated containing a radio-dense tungsten indicator rod that moves and can be measured within the screw cannulation when the screw bends under load via plain radiography. Screw bending was assessed in intact femurs and unstable A1 intertrochanteric fractures using experimental axial loading of femoral composite Sawbones® and femoral human cadaveric specimens. Sensor readings were visually tracked using plain radiographs at each load state. The sensor exhibited linear response to implant strain in the unstable fracture indicating that the implant supported the major component of the applied load. This was consistently measurable using radiography throughout loading cycles across the mechanical and cadaveric fracture models. Sensor readings indicated that the implant was mostly unloaded in the intact models. The slope of the curve was approximately equal in the composite and cadaveric models (1.0 µm/N and 0.08 µm/N, respectively). Sensor noise levels were sufficient to detect 10% of the applied load of 80 kg, which has the potential to qualitatively assist clinicians in tracking fracture healing progression. Clinicians must carefully monitor their patients for signs of SHS implant failure after surgery. This device quantitively measures implant loading which could qualitatively assist clinicians in the assessment of fracture healing.

滑动髋关节螺钉内固定治疗髋关节转子间骨折后的骨愈合很难通过放射摄影进行监测。在本研究中，我们描述并评估了一种非侵入式确定螺钉植入物负荷的装置，该装置可作为骨愈合的定性指标。我们制作了一种新型载荷感应滑动髋关节螺钉（LS-SHS），其中包含一根放射性致密钨指示杆，当螺钉在载荷作用下弯曲时，指示杆会移动并可通过普通射线照相术在螺钉套管内进行测量。通过对股骨复合锯骨®和股骨人体尸体标本进行实验性轴向加载，评估了完整股骨和不稳定 A1 转子间骨折的螺钉弯曲情况。在每种加载状态下，均使用平片对传感器读数进行视觉跟踪。在不稳定骨折中，传感器对植入体应变表现出线性响应，表明植入体支撑了外加载荷的主要部分。在机械和尸体骨折模型的整个加载周期中，使用射线照相术始终可以测量到这一点。传感器读数表明，在完好的模型中，植入体大部分处于空载状态。复合模型和尸体模型的曲线斜率大致相同（分别为 1.0 µm/N 和 0.08 µm/N）。传感器的噪音水平足以检测到 80 千克外加载荷的 10%，这有可能为临床医生跟踪骨折愈合进展提供定性帮助。临床医生必须仔细监测患者术后是否出现 SHS 植入物失效的迹象。该设备能定量测量植入物的负荷，有助于临床医生对骨折愈合情况进行定性评估。

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引用次数: 0

A kinematically reasonable mechanism of tongue forward protrusion considering hyoid bone movements 考虑舌骨运动的舌前突的运动学合理机制。

IF 2.4 3区医学 Q3 BIOPHYSICS

Journal of biomechanics

Pub Date : 2025-01-01 DOI: 10.1016/j.jbiomech.2024.112445

Kyoichi Inoue , Tomohiro Otani , Kazunori Nozaki , Tsukasa Yoshinaga , Shigeo Wada

The tongue has a wide variety of motor functions, which are driven by tongue muscle contractions and associated with movements of the hyoid bone (HB) connected to the tongue root. HB movement has been observed in many situations, including swallowing, breathing, and speech. However, the relationships between HB movement and tongue kinematic function have received little attention, and have not been considered in most previous biomechanical tongue modeling research, except studies of swallowing. The current study aimed to clarify the effects of HB movement on tongue kinematics during tongue forward protrusion, which is an essential tongue motor function associated with speech disorder. HB displacement during tongue forward protrusion was quantified using ultrasound imaging in four healthy controls. Furthermore, computational mechanical simulations of tongue forward protrusion were conducted with observed HB movements and active contraction of the genioglossus (GG) muscle, which is conventionally considered to be the driving muscle in tongue forward protrusion. Ultrasound imaging revealed anterosuperior HB displacement in tongue forward protrusion, with a similar magnitude in each direction (anterior: 6.3 ± 2.8 mm, superior: 5.8 ± 1.6 mm). Computational simulation demonstrated that the HB movement described above caused not only anterosuperior displacement, but also forward rotation of the tongue body, which was caused by kinematic constraints of GG. The resulting anterior displacement of the tongue tip was 1.5 times greater compared with that without HB movement. These findings indicate that the HB and associated tongue body movements play non-negligible roles in the tongue kinematics of forward protrusion.

舌有多种运动功能，这些功能是由舌肌收缩驱动的，并与连接舌根的舌骨（HB）的运动有关。在许多情况下，包括吞咽、呼吸和说话，都观察到HB运动。然而，HB运动与舌头运动功能之间的关系很少受到关注，并且在之前的大多数生物力学舌头建模研究中都没有考虑到，除了吞咽研究。本研究旨在阐明HB运动对舌前伸过程中舌运动的影响，舌前伸是与语言障碍相关的基本舌运动功能。在4名健康对照中，使用超声成像量化舌前突时的HB位移。此外，对舌前突进行了计算力学模拟，观察了HB的运动和颏舌肌（GG）的主动收缩，GG肌通常被认为是舌前突的驱动肌肉。超声示舌前突为前上HB移位，各方向大小相近（前：6.3±2.8 mm，上：5.8±1.6 mm）。计算仿真表明，上述HB运动不仅引起舌体的前后位移，还引起舌体的前向旋转，这是由GG的运动学约束引起的，舌尖的前向位移是没有HB运动时的1.5倍。这些结果表明，HB和相关舌体运动在舌前突的运动学中起着不可忽视的作用。

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引用次数: 0

Interpretation of intra-operative strain differences in ascending thoracic aortic repair patients 升胸主动脉修复术患者术中应变差异分析。

IF 2.4 3区医学 Q3 BIOPHYSICS

Journal of biomechanics

Pub Date : 2025-01-01 DOI: 10.1016/j.jbiomech.2024.112447

Shaiv Parikh , Anne Wehrens , Alessandro Giudici , Berta Ganizada , Pepijn Saraber , Leon Schurgers , Gijs Debeij , Ehsan Natour , Jos Maessen , Wouter Huberts , Tammo Delhaas , Koen Reesink , Elham Bidar

Local biaxial deformation plays a pivotal role in evaluating the tissue state of the ascending aorta and in driving intramural cell-mediated tissue remodeling. Unfortunately, the absence of anatomical markers on the ascending aorta presents challenges in capturing deformation. Utilizing our established intra-operative biaxial strain measurement method, we delineated local biaxial deformation characteristics in patients undergoing aortic valve replacement and coronary artery bypass graft surgery recipients (n = 20), and Aortic Repair surgery patients (n = 47). Expectedly, mean circumferential strains positively correlated with pulse pressure and negatively correlated with age and diameter. A new observation was that the mean axial strains exhibited the same trend as the mean circumferential strains when correlated with pulse pressure, age and diameter. Interestingly, on analyzing local biaxial strains, our findings revealed higher circumferential strains (by 1 %) proximal to the heart compared to distal regions across the cohorts and within each patient cohort. Furthermore, no discernible regional strain distinctions were noted between the medial and lateral sides of the ascending aorta for the entire patient population and individual cohorts. Patients undergoing Aortic Repair surgery indicated lower strains (ranging from 1 to 3 %) as compared to the other cohort. Our approach holds the potential to establish a foundational framework for the integrated examination of the mechanical and biological conditions and their role in ascending aortic aneurysm development.

局部双轴变形在评估升主动脉组织状态和驱动壁内细胞介导的组织重构中起关键作用。不幸的是，升主动脉解剖标记的缺失给捕捉变形带来了挑战。利用我们建立的术中双轴应变测量方法，我们描绘了主动脉瓣置换术和冠状动脉搭桥术患者（n = 20）和主动脉修复术患者（n = 47）的局部双轴变形特征。平均周向应变与脉压正相关，与年龄、径负相关。在脉冲压力、年龄和直径的关系中，轴向应变的变化趋势与周向应变的变化趋势一致。有趣的是，在分析局部双轴应变时，我们的研究结果显示，在整个队列和每个患者队列中，与远端区域相比，心脏近端区域的周向应变更高（1%）。此外，在整个患者群体和个体队列中，升主动脉内侧和外侧之间没有明显的区域应变差异。与其他队列相比，接受主动脉修复手术的患者显示较低的菌株（范围为1%至3%）。我们的方法有可能为综合检查机械和生物条件及其在升主动脉瘤发展中的作用建立一个基础框架。

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