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Mechanical modeling of the dynamic response of the knee joint angle in the evaluation of muscle nerve response and energy consumption
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2025-02-05 DOI: 10.1016/j.jbiomech.2025.112565
Hongyan Liu , Bailu Zhao , Qi Wang , Junghee Lee , Lei Liu , Peilong Xu , Jongchul Park
Knee joint has large loads and pressures during human movement, and understanding knee joint’s dynamic response during movement is crucial to the study of movement mechanisms and the design of effective rehabilitation programs. In order to improve the accuracy of the mechanical model in the assessment of musculo-neural response and energy consumption in the knee joint movement mechanism, the study tries to calculate the values of mass, stiffness and damping based on the ‘mass-stiffness-damping’ model combined with the Vicon system and Moxy sensors, and further analyse the musculo-neural response and energy consumption based on the measurement of the joint angle and the joint torque. The muscle nerve response and energy consumption were further analyzed. After experimental analysis, these results show that the average fitting accuracy of the knee motion at different heights reaches more than 96.5%; in comparison of the sensitivity of the knee muscle nerve response, the research model is better than the other models in terms of the stability of the response; and the change of the knee angle and angular velocity at different walking speeds leads to different degrees of energy dissipation. In summary, the mechanical model based on the “mass-stiffness-damping” model combined with the application of motion capture system and muscle oxygenation monitoring equipment provides an important method and tool for the study of knee joint angle’s dynamic response, the muscle nerve response and the evaluation of energy consumption.
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引用次数: 0
Computed gastrocnemius muscle moment arm based on wrapping objects derived from 3D ultrasound: Exploring the impact of ankle position and predictability of anthropometrics
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2025-02-04 DOI: 10.1016/j.jbiomech.2025.112556
Eric Irani , Shuo Chen , Sepehr Ramezani , Amit Patel , Jason B. Malone , Hyunjun Shin , Hwan Choi
The objective of this study was to evaluate the effectiveness of subject-specific wrapping objects (SS.WOs) derived from 3D ultrasound measurements in calculating the musculotendon moment arm, particularly the lateral gastrocnemius muscle moment arm at the knee (Gas.lat KMA). Computed musculoskeletal modeling, essential for understanding human locomotion, often shows discrepancies compared to in vivo measurements. This research investigated whether SS.WOs, tailored to individual muscle paths across different joint configurations, could mitigate these discrepancies. Ten healthy participants were subjected to 3D ultrasound to record the Gas.lat path at various knee and ankle angles. This data was utilized to develop SS.WOs in a scaled Rajagopal Full-body model (SS-Rajagopal). We assessed the impact of the modeling approach and ankle position on the computed Gas.lat KMA by comparing it with results from two scaled generic models (SC-Rajagopal and SC-Gait2392). There was no significant effect of ankle position on Gas.lat KMA across all knee angles; however, the choice of modeling approach markedly influenced the outcomes. The computed Gas.lat KMA from SS-Rajagopal more closely matched in vivo measurements at higher knee angles compared to SC-Rajagopal. Significant correlations were observed between the computed Gas.lat KMA from both SS-Rajagopal and SC-Rajagopal with anthropometric measurements. However, no correlation was found between the properties of SS.WOs and individual anthropometrics. In conclusion, while optimization techniques such as muscle path computation with WOs improve musculoskeletal modeling efficiency, they may not fully address inter-subject variability.
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引用次数: 0
On the number of steps required to measure the mean and variability of spatio-temporal parameters at preferred running speed
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2025-02-04 DOI: 10.1016/j.jbiomech.2025.112563
Antoine Godin , Esther Eustache , Yoshimasa Sagawa Jr. , Laurent Mourot
Preferred running speed is a relevant condition for measuring spatio-temporal parameters and their variability as it theoretically corresponds to an intensity where the energy cost, the biomechanical constraints and the pleasure are optimal. The objective of this study was to evaluate 1) the between-days reliability of spatio-temporal parameters measurements at preferred running speed and 2) the minimal number of steps required to obtain a representative measurement. Thirty-one recreational runners (age: 26 ± 5.5 years; running experience > 2 years) performed three sessions of treadmill running at preferred running speed separated by 24 h. Spatio-temporal parameters were stride, step, contact and flight times, cadence, step length, duty factor, vertical and leg stiffness. Mean, linear and non-linear measurements of spatio-temporal parameters were computed. Reliability was determined using intraclass coefficient correlation and his 95 % confidence interval lower band (95 %LB). Number of steps required for intra-session representativity were defined as the first number of steps from which all measurements are equal to the measurement at the longer time series length. For all spatio-temporal parameters, mean data showed excellent reliability (95 %LB > 0.90) but most spatio-temporal parameters linear and non-linear variability measurements showed questionable reliability (95 %LB < 0.79). The absolute speed variation at preferred running speed (minimal detectable change 0.8 km/h) may explain these results. Representative values required between 16 and 352 steps for mean value of spatio-temporal parameters, between 16 and 400 steps for linear measurements, and between 336 and 704 steps for non-linear measurements.
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引用次数: 0
Motor control complexity estimation using gait measures in individuals post-stroke
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2025-02-04 DOI: 10.1016/j.jbiomech.2025.112562
Azarang Asadi , Jill S. Higginson , Jeffrey A. Reinbolt
Motor control impairments post-stroke significantly limit walking ability, with residual gait impairments often persisting despite rehabilitation efforts. Integrating motor control-based assessments in post-stroke gait evaluations is essential for monitoring the underlying causes of the limited functionality and enhancing recovery outcomes. This study aimed to develop motor control-based post-stroke gait evaluation techniques using common gait measures to inform and guide rehabilitation decisions.
Subject-specific, forward-dynamic simulations of eight individuals with post-stroke gait undergoing a 12-weeks FastFES gait retraining program were created pre- and post-treatment to determine muscle activation patterns for muscle module analysis. The motor control complexity index was defined by the variance not accounted for by one module (VNAF1) as a summary measure of the analysis. Twenty-eight gait measures were investigated, and the relevant measures were selected using feature selection methods and fed into a multiple linear regression model to estimate the motor control complexity index.
The motor control complexity of 182 gait cycles were quantified (0.164 ± 0.047). No strong relationship (quantified using Pearson correlation coefficients) was found between gait measures and the motor control complexity index. However, a combination of four gait measures from the paretic side (maximum hip abduction and knee flexion angle during swing, knee range of motion, and maximum paretic ankle power) explained most of the variation (R2 = 0.66) in motor control complexity.
中风后的运动控制障碍极大地限制了行走能力,尽管进行了康复治疗,但残余的步态障碍往往依然存在。在卒中后步态评估中整合基于运动控制的评估对于监测功能受限的根本原因和提高康复效果至关重要。本研究旨在利用常见的步态测量方法,开发基于运动控制的中风后步态评估技术,为康复决策提供信息和指导。研究人员在治疗前和治疗后对接受为期12周的FastFES步态再训练计划的8名中风后步态患者进行了特定对象的前向动态模拟,以确定肌肉模块分析的肌肉激活模式。运动控制复杂性指数由一个模块未考虑的方差(VNAF1)定义,作为分析的总结性指标。研究人员对 28 种步态测量方法进行了调查,并使用特征选择方法选出了相关测量方法,将其输入多元线性回归模型,以估算运动控制复杂性指数。在步态测量和运动控制复杂度指数之间没有发现很强的关系(用皮尔逊相关系数量化)。然而,来自瘫痪侧的四项步态测量指标(摆动时的最大髋关节外展和膝关节屈曲角度、膝关节活动范围和瘫痪踝关节最大力量)的组合解释了运动控制复杂性的大部分变化(R2 = 0.66)。
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引用次数: 0
A generalized objective CT-based method for quantifying articular fracture severity 一种基于广义客观ct的关节骨折严重程度量化方法。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2025-02-01 DOI: 10.1016/j.jbiomech.2024.112432
Kevin N. Dibbern , Andrew M. Kern , Donald D. Anderson
A CT-based method for objectively assessing fracture severity was previously developed and validated to address poor reliability in existing subjective fracture classification systems. The method involved quantifying the energy involved in creating a fracture. However, clinical utility of the method was hindered by reliance upon an intact contralateral CT and lengthy analysis time (8–10 h). Significant methodological improvements detailed here enable the assessment of fracture severity in any joints and bones, while obviating the need for an intact contralateral CT scan. Analysis time was reduced to <2 h per case. Fracture energies computed using the new methods showed strong agreement (R2 = 0.95, p < 0.001) with prior results in analyzing twenty tibial pilon fractures. New metrics, articular fracture edge length and subchondral energy, were developed to better describe joint injuries by incorporating knowledge of preferential chondrocyte death along fracture edges. Based on two-year radiographic grading for these pilon fractures, fracture energy, articular fracture edge length, and subchondral energy were all significantly different (p < 0.01) between cases that did or did not develop post-traumatic osteoarthritis. These developments enable measurement of fracture severity in larger populations and in more clinically relevant timeframes with articular fractures involving a variety of joints and bones. This generalized assessment method offers opportunity to change the way severity is considered in fracture treatment algorithms. Studies involving larger cohorts are anticipated to yield insights into the impact of fracture severity on PTOA risk and serve as a foundation for evaluating new treatment strategies.
为了解决现有主观骨折分类系统可靠性差的问题,之前开发并验证了一种基于ct的客观评估骨折严重程度的方法。该方法包括量化产生裂缝所涉及的能量。然而,该方法的临床应用受到依赖完整的对侧CT和冗长的分析时间(8-10小时)的阻碍。本文详细介绍了方法的重大改进,可以评估任何关节和骨骼的骨折严重程度,同时避免了对侧完整CT扫描的需要。分析时间减少到2 = 0.95,p
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引用次数: 0
Unlocking the multidimensionality of plantar pressure measurements for the evaluation of footwear in people with diabetes 解锁糖尿病患者鞋履评估足底压力测量的多维度。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2025-02-01 DOI: 10.1016/j.jbiomech.2025.112502
L.E. Vossen, S.A. Bus, J.J. Van Netten
The offloading effectiveness of custom-made footwear for people with diabetes is assessed using plantar pressure measurements. While such pressure data is multidimensional, it is mostly analyzed using a scalar − maximum peak plantar pressure (PMax). We aimed to investigate the associations between multiple peak plantar pressure parameters for footwear assessment and determine whether this assessment depends on the chosen parameter. In-shoe plantar pressure was measured in 77 participants with diabetes, peripheral neuropathy, and a recent ulcer or amputation history, while walking in their own custom-made footwear. Six peak plantar pressure parameters were extracted, both scalar (i.e. Pmax, time integral and gradient) and multidimensional (i.e. time curve, map and time map). Footwear was ranked from highest to lowest outcome for each parameter and associations with Pmax were compared using Spearman’s rank correlation coefficient. A footwear comparison within subjects using Fleiss’ Kappa analysis determined the agreement between parameters using two pairs of footwear of each participant. The rank correlation coefficient was moderate to strong between PMax and the other scalar parameters (ρ = 0.46–0.70), and negligible to weak between PMax and the multidimensional parameters (ρ = 0.03–0.25). Percentage agreement between parameters for the within-subject footwear comparison was poor (47.5 %, κ = 0.0652). We conclude that the association and agreement between in-shoe peak pressure parameters is low and the assessment of offloading effectiveness depends on the chosen parameter. This is the first step in unlocking the potential of a multidimensional approach in plantar pressure analysis, possibly changing how we evaluate footwear offloading effectiveness.
使用足底压力测量来评估糖尿病患者定制鞋的卸荷效果。虽然这些压力数据是多维的,但大多使用标量-最大峰值足底压力(PMax)进行分析。我们的目的是研究鞋履评估中多个峰值足底压力参数之间的关系,并确定这种评估是否取决于所选择的参数。研究人员测量了77名患有糖尿病、周围神经病变、近期有溃疡或截肢史的参与者穿着自己定制的鞋子走路时的鞋内足底压力。提取了6个峰值足底压力参数,包括标量参数(即Pmax、时间积分和梯度)和多维参数(即时间曲线、地图和时间地图)。每个参数的结果从高到低对鞋类进行排序,并使用Spearman等级相关系数比较与Pmax的关联。使用Fleiss的Kappa分析在受试者中进行鞋类比较,确定了每个参与者使用两双鞋类的参数之间的一致性。PMax与其他标量参数之间的等级相关系数为中强(ρ = 0.46 ~ 0.70),而PMax与多维参数之间的等级相关系数为弱(ρ = 0.03 ~ 0.25)。受试者内部鞋类比较参数之间的百分比一致性较差(47.5%,κ = 0.0652)。结果表明,鞋内峰值压力参数之间的相关性和一致性较低,卸载效果的评估取决于所选择的参数。这是释放足底压力分析多维方法潜力的第一步,可能会改变我们评估鞋子卸载效果的方式。
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引用次数: 0
Evaluating interface pressure in a lower-limb prosthetic socket: Comparison of FEM and experimental measurements on a roll-over simulator 评估下肢义肢窝内的界面压力:在翻转模拟器上的有限元和实验测量的比较。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2025-02-01 DOI: 10.1016/j.jbiomech.2025.112513
Maïalen Matray , Xavier Bonnet , Pierre-Yves Rohan , Laurine Calistri , Hélène Pillet
Improper socket fitting in lower-limb prostheses can lead to significant complications, including pain, skin lesions, and pressure ulcers. Current suspension and socket design practices rely predominantly on visual inspection of the residual limb and patient feedback. Monitoring stress distribution at the residual limb/socket interface offers a more objective approach. Finite Element Analysis (FEA) enables to estimate interface pressure distribution prior to manufacture to provide the orthoprosthetist with quantitative data during socket rectification and interface prosthetic components selection. However, although numerous FEA models are available, few have undergone rigorous validation against experimental pressure data. Indeed, limitations of commercial pressure sensors typically include cumbersomeness or imprecision, thereby hindering systematic measurements within the socket. In this study, we introduce a low-cost, accurate pressure sensing system integrated into 3D-printed sockets for FEA validation. The system is implemented on a roll-over simulator that uses a mock limb to mimic the interaction between a transtibial residual limb and socket during the unipodal stance phase. A FEA of the simulator was then conducted, and predicted interface pressures were compared to experimental measurements at seven discrete locations. The model demonstrated a high degree of sensitivity to the geometry of the mock limb; however, with an accurate shape description, it was able to predict pressure with an average absolute error of 12 kPa. This work advances the validation of residual limb FEA for estimating residual limb/socket interface pressures. It highlights the potential of FEA for designing data-driven sockets and ultimately improve the comfort of prosthesis users.
下肢假体的套孔安装不当会导致严重的并发症,包括疼痛、皮肤损伤和压疮。目前的悬吊和关节窝设计主要依赖于残肢的目视检查和患者反馈。监测残肢/窝界面的应力分布提供了更客观的方法。有限元分析(FEA)能够在制造之前估计界面压力分布,为矫形义肢医师提供在套孔矫正和界面义肢组件选择期间的定量数据。然而,尽管有许多可用的有限元模型,但很少有模型经过严格的实验压力数据验证。事实上,商用压力传感器的局限性通常包括笨重或不精确,从而阻碍了插座内的系统测量。在本研究中,我们介绍了一种低成本,精确的压力传感系统集成到3d打印插座中,用于有限元分析验证。该系统是在一个翻转模拟器上实现的,该模拟器使用一个模拟肢体来模拟在单足站立阶段,跨胫残肢和关节窝之间的相互作用。然后对模拟器进行了有限元分析,并将预测的界面压力与七个离散位置的实验测量结果进行了比较。该模型对模拟肢体的几何形状具有高度的敏感性;然而,通过精确的形状描述,它能够预测压力,平均绝对误差为12 kPa。本工作进一步验证了残肢有限元法估算残肢/承插界面压力的有效性。它强调了有限元分析在设计数据驱动的插座和最终提高义肢使用者舒适度方面的潜力。
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引用次数: 0
Sprint runners have longer Achilles tendon moment arm than distance runners
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2025-02-01 DOI: 10.1016/j.jbiomech.2025.112557
Bálint Kovács , András Hegyi , Gu Yaodong , István Kóbor , Gyula Gyebnár , József Tihanyi , Annamária Péter
The length of the Achilles tendon moment arm may affect muscle shortening velocity, ankle moment, and running economy in running. Regarding the direction of these effects, experimental studies are controversial. These typically use simplified 2-D methods to define the length of the moment arm, and data on high-level athletes are scarce. The purpose of this study was to use a 3-D approach to estimate the length of the Achilles tendon moment arm and examine its association with sprint and endurance running performance in high-level competitive runners.
Twenty-nine healthy adult competitive runners were recruited, including fifteen distance runners (IAAF score = 953 ± 116, mean ± standard deviation) and fourteen sprint runners (IAAF score = 993 ± 113). The length of the Achilles tendon moment arm was estimated from T1 weighted MRI scans taken at a 90° ankle angle.
The sprint runners had longer Achilles tendon moment arms compared to the distance runners when considering absolute lengths (51.8 ± 2.1 mm vs. 48.7 ± 3.8 mm, p = 0.017, Cohen’s d = -0.94), as well as after normalizing to body height (p = 0.004, d = -1.14). However, we did not find any correlation between the absolute or normalized Achilles tendon moment arm length and personal best running performance in either group.
However, longer moment arm may be due to the relatively larger plantar flexor muscle size which can probably offset the detrimental effects of a longer moment arm. On the other hand, distance runners may benefit from a relatively shorter moment arm due to lower forces and increased need for fatigue-resistance. We found no evidence that plantar flexor moment arm is detrimental to running performance in either group, therefore, practitioners should not be concerned about the effects of increasing muscle size on the increase in Achilles tendon moment arm.
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引用次数: 0
An in-silico investigation of the effect of changing cycling crank power and cadence on muscle energetics and active muscle volume 改变循环曲柄功率和节奏对肌肉能量学和活跃肌肉体积影响的计算机研究。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2025-02-01 DOI: 10.1016/j.jbiomech.2025.112530
Cristian D. Riveros-Matthey , Timothy J. Carroll , Mark J. Connick , Glen A. Lichtwark
This study used musculoskeletal modelling to explore the relationship between cycling conditions (power output and cadence) and muscle activation and metabolic power. We hypothesized that the cadence that minimized the simulated average active muscle volume would be higher than the cadence that minimized the simulated metabolic power. We validated the simulation by comparing the predicted muscle activation and fascicle velocities with experimental electromyography and ultrasound images. We found strong correlations for averaged muscle activations and moderate to good correlations for fascicle dynamics. These correlations tended to weaken when analyzed at the individual participant level. Our study revealed a curvilinear relationship between the average active muscle volume and cadence, with the minimum active volume being aligned to the self-selected cadence. The simulated metabolic power was consistent with previous results and was minimized at lower cadences than that which minimized active muscle volume across power outputs. Although there are some limitations to the musculoskeletal modelling approach, the findings suggest that minimizing active muscle volume may be a more important factor than minimizing metabolic power for self-selected cycling cadence preferences. Further research is warranted to explore the potential of an active muscle volume-based objective function for control schemes across a wider range of cycling conditions.
本研究使用肌肉骨骼模型来探索循环条件(功率输出和节奏)与肌肉激活和代谢能力之间的关系。我们假设最小化模拟平均活跃肌肉量的节奏将高于最小化模拟代谢能力的节奏。我们通过将预测的肌肉激活和肌束速度与实验肌电图和超声图像进行比较来验证模拟。我们发现平均肌肉激活的强相关性和束动力的中等到良好的相关性。当分析个体参与者水平时,这些相关性趋于减弱。我们的研究揭示了平均活动肌肉量与节奏之间的曲线关系,最小活动肌肉量与自我选择的节奏一致。模拟的代谢能力与先前的结果一致,并且在较低的节奏下最小化,而不是在功率输出中最小化活动肌肉量。尽管肌肉骨骼建模方法存在一些局限性,但研究结果表明,对于自我选择的骑行节奏偏好,最小化活动肌肉体积可能比最小化代谢能力更重要。进一步的研究是有必要的,以探索在更广泛的循环条件下控制方案的基于活动肌肉体积的目标函数的潜力。
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引用次数: 0
Sternum drop as a kinematic measure of trip recovery performance
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2025-02-01 DOI: 10.1016/j.jbiomech.2025.112499
Youngjae Lee, Michael L. Madigan
Deficient trip recovery kinematics have been implicated in many trip-induced falls. Three key requisites for successful trip recovery include limiting trunk flexion, maintaining adequate hip height to enable repeated stepping, and completing recovery steps to extend the base of support. The purpose of this study was to evaluate sternum drop as a new measure of trip recovery performance. Sternum drop may be a more robust than other measures of trip recovery performance because, unlike other common trip recovery measures, it is sensitive to two of the three trip recovery requisites. Thirty community-dwelling older adults were exposed to two laboratory-induced trips while walking on a walkway. Sternum drop was determined using two separate methods: from optoelectronic motion capture and an inertial measurement unit. For comparison sternum drop, trunk angle and hip height, both at touchdown of the first recovery step, were also determined. Sternum drop from optoelectronic motion capture exhibited strong correlation with trunk angle at touchdown (repeated-measures correlation coefficient (rrm) = 0.94; p < 0.001), strong correlation with hip height at touchdown (rrm = -0.90; p < 0.001), and strong correlation with sternum drop from IMU (rrm = 0.95; p < 0.001). In addition, sternum drop from optoelectronic motion capture (p < 0.001) and sternum drop from inertial measurement unit (p = 0.001) differed between falls and recoveries, with the former exhibiting the largest effect size (partial eta2 = 0.36) between falls and recoveries. These results support sternum drop as a valid kinematic measure of trip recovery performance.
许多绊倒导致的跌倒都与绊倒恢复运动学缺陷有关。成功绊倒恢复的三个关键必要条件包括限制躯干屈曲、保持足够的臀部高度以便能够重复迈步,以及完成恢复步骤以扩展支撑基础。本研究的目的是评估胸骨下垂程度,作为衡量绊倒后恢复能力的新标准。胸骨下垂可能比其他绊倒恢复能力的测量方法更可靠,因为与其他常见的绊倒恢复能力测量方法不同,胸骨下垂对三个绊倒恢复必要条件中的两个都很敏感。30 名居住在社区的老年人在人行道上行走时受到了两次实验室诱发的绊倒。胸骨下垂度分别通过光电运动捕捉和惯性测量装置两种方法测定。为了比较胸骨下垂度,还测定了躯干角度和臀部高度,两者都是在第一个恢复步骤触地时测定的。光电运动捕捉法测得的胸骨下垂度与触地时的躯干角度有很强的相关性(重复测量相关系数 (rrm) = 0.94;P rm = -0.90;P rm = 0.95;P 2 = 0.36)。这些结果支持将胸骨下坠作为衡量绊倒恢复性能的有效运动学指标。
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引用次数: 0
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Journal of biomechanics
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