RETRACTION: Y. Wang, G. Li, L. Zhao, and J. Lv, “Long Noncoding RNA HOTTIP Alleviates Oxygen-Glucose Deprivation-Induced Neuronal Injury via Modulating MiR-143/Hexokinase 2 Pathway,” Journal of Cellular Biochemistry 119, no. 12 (2018): 10107-10117, https://doi.org/10.1002/jcb.27348.
The above article, published online on 20 August 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Multiple image elements within Figure 2 C were found to have been published previously by different authors in different scientific contexts. The authors were invited to comment on these concerns but did not respond. Accordingly, the article is retracted as the editors have lost confidence in the integrity and reliability of the full body of data presented in the article and consider its conclusions invalid. The authors were informed of the retraction.
{"title":"RETRACTION: Long Noncoding RNA HOTTIP Alleviates Oxygen-Glucose Deprivation-Induced Neuronal Injury via Modulating MiR-143/Hexokinase 2 Pathway","authors":"","doi":"10.1002/jcb.70020","DOIUrl":"https://doi.org/10.1002/jcb.70020","url":null,"abstract":"<p><b>RETRACTION:</b> Y. Wang, G. Li, L. Zhao, and J. Lv, “Long Noncoding RNA HOTTIP Alleviates Oxygen-Glucose Deprivation-Induced Neuronal Injury via Modulating MiR-143/Hexokinase 2 Pathway,” <i>Journal of Cellular Biochemistry</i> 119, no. 12 (2018): 10107-10117, https://doi.org/10.1002/jcb.27348.</p><p>The above article, published online on 20 August 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Multiple image elements within Figure 2 C were found to have been published previously by different authors in different scientific contexts. The authors were invited to comment on these concerns but did not respond. Accordingly, the article is retracted as the editors have lost confidence in the integrity and reliability of the full body of data presented in the article and consider its conclusions invalid. The authors were informed of the retraction.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RETRACTION: F. Amerizadeh, N. Rezaei, F. Rahmani, S. M. Hassanian, R. Moradi-Marjaneh, H. Fiuji, N. Boroumand, A. Nosrati-Tirkani, M. Ghayour-Mobarhan, G. A. Ferns, M. Khazaei, and A. Avan, “Crocin Synergistically Enhances the Antiproliferative Activity of 5-Flurouracil Through Wnt/PI3K Pathway in a Mouse Model of Colitis-Associated Colorectal Cancer,” Journal of Cellular Biochemistry 119, no. 12 (2018): 10250-10261, https://doi.org/10.1002/jcb.27367.
The above article, published online on August 20, 2018, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl, and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Figure 6B was found to contain inappropriate splicing sites and methodological flaws. Additionally, in Figure 5A and 5a, no correlation was observed between samples at low and high magnification. The authors did not provide clarification on these issues or the original data. Accordingly, the article is retracted as the editors have lost confidence in the integrity and accuracy of the whole body of data presented in the article and consider its conclusions invalid. The authors have been informed of the decision of retraction.
引用本文：F. Amerizadeh， N. Rezaei， F. Rahmani， S. M. Hassanian， R. moradii - marjaneh， H. Fiuji， N. Boroumand, a . nosratii - tirkani， M. ghaour - mobarhan， G. a . Ferns， M. Khazaei, a . Avan，“藏红花素通过Wnt/PI3K途径协同增强5-尿嘧啶在结肠炎相关结直肠癌模型中的抗增殖活性”，细胞生物化学杂志，第119期。12 (2018): 10250-10261, https://doi.org/10.1002/jcb.27367.The上述文章于2018年8月20日在线发表在Wiley在线图书馆（wileyonlinelibrary.com）上，经期刊主编Christian Behl和Wiley期刊有限责任公司同意撤回。由于第三方提出的担忧，已同意撤回。发现图6B包含不合适的剪接位点和方法缺陷。此外，在图5A和5A中，在低倍率和高倍率下，样品之间没有相关性。作者没有对这些问题或原始数据提供澄清。因此，由于编辑对文章中提供的整个数据的完整性和准确性失去信心，并认为其结论无效，因此文章被撤回。作者已被告知撤稿的决定。
{"title":"RETRACTION: Crocin Synergistically Enhances the Antiproliferative Activity of 5-Flurouracil Through Wnt/PI3K Pathway in a Mouse Model of Colitis-Associated Colorectal Cancer","authors":"","doi":"10.1002/jcb.70015","DOIUrl":"https://doi.org/10.1002/jcb.70015","url":null,"abstract":"<p><b>RETRACTION:</b> F. Amerizadeh, N. Rezaei, F. Rahmani, S. M. Hassanian, R. Moradi-Marjaneh, H. Fiuji, N. Boroumand, A. Nosrati-Tirkani, M. Ghayour-Mobarhan, G. A. Ferns, M. Khazaei, and A. Avan, “Crocin Synergistically Enhances the Antiproliferative Activity of 5-Flurouracil Through Wnt/PI3K Pathway in a Mouse Model of Colitis-Associated Colorectal Cancer,” <i>Journal of Cellular Biochemistry</i> 119, no. 12 (2018): 10250-10261, https://doi.org/10.1002/jcb.27367.</p><p>The above article, published online on August 20, 2018, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl, and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Figure 6B was found to contain inappropriate splicing sites and methodological flaws. Additionally, in Figure 5A and 5a, no correlation was observed between samples at low and high magnification. The authors did not provide clarification on these issues or the original data. Accordingly, the article is retracted as the editors have lost confidence in the integrity and accuracy of the whole body of data presented in the article and consider its conclusions invalid. The authors have been informed of the decision of retraction.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RETRACTION: J. Wang, L. Yang, L. Wang, Y. Yang, and Y. Wang, “Forkhead Box p3 Controls Progression of Oral Lichen Planus by Regulating MicroRNA-146a, ” Journal of Cellular Biochemistry 119, no. 11 (2018): 8862-8871, https://doi.org/10.1002/jcb.27139.
The above article, published online on 20 August 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Image elements within Figures 2E, 3D and 5 A were found to have been published previously by different authors in different scientific contexts. The authors were invited to comment on these concerns but did not respond. Accordingly, the article is retracted as the editors have lost confidence in the integrity and reliability of the full body of data presented in the article and consider its conclusions invalid. The authors were informed of the retraction.
退稿：J. Wang, L. Yang, L. Wang, Y. Yang, and Y. Wang, "Forkhead Box p3 Controls Progression of Oral Lichen Planus by Regulating MicroRNA-146a, " Journal of Cellular Biochemistry 119, no：8862-8871, https://doi.org/10.1002/jcb.27139.The 上述文章于 2018 年 8 月 20 日在线发表于 Wiley Online Library (wileyonlinelibrary.com)，经期刊主编 Christian Behl 和 Wiley Periodicals LLC 协议，该文章已被撤回。同意撤稿的原因是第三方提出的疑虑。图 2E、3D 和 5 A 中的图像元素被发现曾由不同作者在不同科学背景下发表过。我们邀请作者就这些问题发表评论，但他们没有回应。因此，由于编者对文章中提供的全部数据的完整性和可靠性失去信心，并认为其结论无效，文章被撤回。已将撤稿通知作者。
{"title":"RETRACTION: Forkhead Box p3 Controls Progression of Oral Lichen Planus by Regulating MicroRNA-146a","authors":"","doi":"10.1002/jcb.70019","DOIUrl":"https://doi.org/10.1002/jcb.70019","url":null,"abstract":"<p><b>RETRACTION:</b> J. Wang, L. Yang, L. Wang, Y. Yang, and Y. Wang, “Forkhead Box p3 Controls Progression of Oral Lichen Planus by Regulating MicroRNA-146a, ” <i>Journal of Cellular Biochemistry</i> 119, no. 11 (2018): 8862-8871, https://doi.org/10.1002/jcb.27139.</p><p>The above article, published online on 20 August 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Image elements within Figures 2E, 3D and 5 A were found to have been published previously by different authors in different scientific contexts. The authors were invited to comment on these concerns but did not respond. Accordingly, the article is retracted as the editors have lost confidence in the integrity and reliability of the full body of data presented in the article and consider its conclusions invalid. The authors were informed of the retraction.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jingjing Liu, Xuhui Liu, Xiaohang Xie, Wei Si, Yuhang Zhang, Mengjiao Xue, Xuyan Peng, Mingjun Jiang, Shanshan Du, Jingzhi Shao, Yi Mao, Fengyan Zhang, Yanzhong Hu
Small extracellular vesicles (SEVs) are membrane-bound vesicles secreted by cells that facilitate intercellular communication. This study reveals how heat shock transcription factor 4 (HSF4) deficiency regulates SEV secretion in lens epithelial cells through chaperone-mediated autophagy (CMA). Compared to mLEC/HA-Hsf4b cells, SEVs secreted by HSF4-deficient mLEC/Hsf4−/− cells showed significantly increased levels of CMA-related proteins (HSP70, HSC70, LAMP2A, and HSP90) and EGFR, while LC3 II levels were reduced. Additionally, EGFR-enriched SEVs activated downstream ERK/AKT signaling pathways, promoting the proliferation and migration of lens epithelial cells and inducing epithelial–mesenchymal transition (EMT). Further inhibition experiments showed that blocking HSP70 and HSP90 with apoptozole and retaspimycin, or silencing LAMP2A with siRNA, reduced SEV secretion in HSF4-deficient cells. Collectively, enhanced CMA activity and increased SEV secretion induced by HSF4 deficiency may represent a potential mechanism underlying congenital cataract development.
{"title":"Deficiency of HSF4 Increases the Secretion of Small Extracellular Vesicles via Upregulation of Chaperone-Mediated Autophagy","authors":"Jingjing Liu, Xuhui Liu, Xiaohang Xie, Wei Si, Yuhang Zhang, Mengjiao Xue, Xuyan Peng, Mingjun Jiang, Shanshan Du, Jingzhi Shao, Yi Mao, Fengyan Zhang, Yanzhong Hu","doi":"10.1002/jcb.70031","DOIUrl":"https://doi.org/10.1002/jcb.70031","url":null,"abstract":"<div>\u0000 \u0000 <p>Small extracellular vesicles (SEVs) are membrane-bound vesicles secreted by cells that facilitate intercellular communication. This study reveals how heat shock transcription factor 4 (HSF4) deficiency regulates SEV secretion in lens epithelial cells through chaperone-mediated autophagy (CMA). Compared to mLEC/HA-Hsf4b cells, SEVs secreted by HSF4-deficient mLEC/Hsf4<sup>−/−</sup> cells showed significantly increased levels of CMA-related proteins (HSP70, HSC70, LAMP2A, and HSP90) and EGFR, while LC3 II levels were reduced. Additionally, EGFR-enriched SEVs activated downstream ERK/AKT signaling pathways, promoting the proliferation and migration of lens epithelial cells and inducing epithelial–mesenchymal transition (EMT). Further inhibition experiments showed that blocking HSP70 and HSP90 with apoptozole and retaspimycin, or silencing LAMP2A with siRNA, reduced SEV secretion in HSF4-deficient cells. Collectively, enhanced CMA activity and increased SEV secretion induced by HSF4 deficiency may represent a potential mechanism underlying congenital cataract development.</p></div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Solanum erianthum D. Don (Solanaceae) species has wide range of usage in treating disease in folk medicine. This study focused on the isolation and characterization of Phytol, βCaryophyllene (βc), and Methoxy - 4- Quercetin (M4Q) from Solanum erianthum leaf and seed fractions. These three compounds were studied for antioxidant activities using DPPH, SOD, and FRAP assays, accompanied by molecular docking, molecular dynamics, and ADMET tools. Our results showed that, Methoxy 4-Quercetin scored good antioxidant potential in the studied assays, with a stable conformation and favorable properties. Docking analysis was used to determine the binding energies of these compounds with different receptor proteins and ligand complexes, as well as their stability, conformation, and binding energy in molecular dynamics. Pharmacokinetic compounds exhibit kinetic values and drug-like characteristics, indicating their biological activity. Competent studies on the compounds using in silico analyses showed that all compounds have notable anti-cardiotoxic and anti-inflammatory effects. Thus, studies on phytocompounds as effective leads to the improvement of anti-inflammatory and anti-cardio agents are necessary for further in vivo studies.
摘要龙葵属（Solanum erianthum D. Don）在民间医学中具有广泛的治疗疾病的用途。本研究主要从茄子叶片和种子中分离鉴定叶绿醇、β石竹烯（βc）和甲氧基- 4-槲皮素（M4Q）。通过DPPH、SOD和FRAP检测，结合分子对接、分子动力学和ADMET工具，研究了这三种化合物的抗氧化活性。结果表明，甲氧基4-槲皮素具有良好的抗氧化活性，具有稳定的构象和良好的性质。通过对接分析，确定了这些化合物与不同受体蛋白和配体复合物的结合能，以及它们在分子动力学中的稳定性、构象和结合能。药代动力学化合物表现出动力学值和药物样特性，表明其生物活性。对化合物的硅分析研究表明，所有化合物都具有显著的抗心脏毒性和抗炎作用。因此，研究植物化合物作为有效的抗炎和抗心脏药物的改善是进一步的体内研究的必要条件。
{"title":"Molecular Structure Insights Into Antioxidant, Anti-Inflammatory, and Computational Investigations: Molecular Docking and Dynamics Studies on Enzyme Inhibitors","authors":"Ismail sheriff Parvin, Hamza Serina Banu, Ekambaram Gayathiri, Palanisamy Prakash, Somdatta Y. Chaudhari, Thangaraj Pratheep, Subramanian Deepika Priyadharshini, Muthiah Pugalenthi, Jayapandian Narmathasri","doi":"10.1002/jcb.70033","DOIUrl":"https://doi.org/10.1002/jcb.70033","url":null,"abstract":"<div>\u0000 \u0000 <p><i>Solanum erianthum</i> D. Don (Solanaceae) species has wide range of usage in treating disease in folk medicine. This study focused on the isolation and characterization of Phytol, βCaryophyllene (βc), and Methoxy - 4- Quercetin (M4Q) from <i>Solanum erianthum</i> leaf and seed fractions. These three compounds were studied for antioxidant activities using DPPH, SOD, and FRAP assays, accompanied by molecular docking, molecular dynamics, and ADMET tools. Our results showed that, Methoxy 4-Quercetin scored good antioxidant potential in the studied assays, with a stable conformation and favorable properties. Docking analysis was used to determine the binding energies of these compounds with different receptor proteins and ligand complexes, as well as their stability, conformation, and binding energy in molecular dynamics. Pharmacokinetic compounds exhibit kinetic values and drug-like characteristics, indicating their biological activity. Competent studies on the compounds using in silico analyses showed that all compounds have notable anti-cardiotoxic and anti-inflammatory effects. Thus, studies on phytocompounds as effective leads to the improvement of anti-inflammatory and anti-cardio agents are necessary for further in vivo studies.</p>\u0000 </div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RETRACTION: Y. Zhou, C. Shu, and Y. Huang, “Fibronectin Promotes Cervical Cancer Tumorigenesis Through Activating FAK Signaling Pathway,” Journal of Cellular Biochemistry 120, no. 7 (2019): 10988–10997, https://doi.org/10.1002/jcb.28282.
The above article, published online on 11 April 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Multiple image elements in Figures 2B and 3C were found to have been previously published by different author groups in different scientific contexts. Additionally, Figure 3C contains duplication, with the same panel being used to depict different scientific contexts. Accordingly, the article is retracted as the editors consider its conclusions to be invalid.
{"title":"RETRACTION: Fibronectin Promotes Cervical Cancer Tumorigenesis Through Activating FAK Signaling Pathway","authors":"","doi":"10.1002/jcb.70022","DOIUrl":"https://doi.org/10.1002/jcb.70022","url":null,"abstract":"<p><b>RETRACTION:</b> Y. Zhou, C. Shu, and Y. Huang, “Fibronectin Promotes Cervical Cancer Tumorigenesis Through Activating FAK Signaling Pathway,” <i>Journal of Cellular Biochemistry</i> 120, no. 7 (2019): 10988–10997, https://doi.org/10.1002/jcb.28282.</p><p>The above article, published online on 11 April 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Multiple image elements in Figures 2B and 3C were found to have been previously published by different author groups in different scientific contexts. Additionally, Figure 3C contains duplication, with the same panel being used to depict different scientific contexts. Accordingly, the article is retracted as the editors consider its conclusions to be invalid.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RETRACTION: L. Zhang, X. Luo, F. Chen, W. Yuan, X. Xiao, X. Zhang, Y. Dong, Y. Zhang, and Y. Liu, “LncRNA SNHG1 Regulates Cerebrovascular Pathologies as a Competing Endogenous RNA Through HIF-1α/VEGF Signaling in Ischemic Stroke, ” Journal of Cellular Biochemistry 119, no. 7 (2018): 5460-5472, https://doi.org/10.1002/jcb.26705.
The above article, published online on 27 January 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Image elements within Figures 3 C and 6 F were found to have been published previously by different authors in different scientific contexts. The authors were invited to comment on these concerns but did not respond. Accordingly, the article is retracted as the editors have lost confidence in the integrity and reliability of the full body of data presented in the article and consider its conclusions invalid. The authors were informed of the retraction.
{"title":"RETRACTION: LncRNA SNHG1 Regulates Cerebrovascular Pathologies as a Competing Endogenous RNA Through HIF-1α/VEGF Signaling in Ischemic Stroke","authors":"","doi":"10.1002/jcb.70017","DOIUrl":"https://doi.org/10.1002/jcb.70017","url":null,"abstract":"<p><b>RETRACTION:</b> L. Zhang, X. Luo, F. Chen, W. Yuan, X. Xiao, X. Zhang, Y. Dong, Y. Zhang, and Y. Liu, “LncRNA SNHG1 Regulates Cerebrovascular Pathologies as a Competing Endogenous RNA Through HIF-1α/VEGF Signaling in Ischemic Stroke, ” <i>Journal of Cellular Biochemistry</i> 119, no. 7 (2018): 5460-5472, https://doi.org/10.1002/jcb.26705.</p><p>The above article, published online on 27 January 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Image elements within Figures 3 C and 6 F were found to have been published previously by different authors in different scientific contexts. The authors were invited to comment on these concerns but did not respond. Accordingly, the article is retracted as the editors have lost confidence in the integrity and reliability of the full body of data presented in the article and consider its conclusions invalid. The authors were informed of the retraction.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RETRACTION: P. Chen, S. Xu, and J. Qu, “Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway,” Journal of Cellular Biochemistry 119, no. 1 (2018): 366-377, https://doi.org/10.1002/jcb.26189.
The above article, published online on 6 June 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Multiple image elements within Figures 2 A and 4 A were found to have been published previously and/or subsequently by different authors in different scientific contexts. Furthermore, evidence of inappropriate image editing/manipulation were found within Figure 3 C. The authors were invited to comment on these concerns but did not respond. Accordingly, the article is retracted as the editors have lost confidence in the integrity and reliability of the full body of data presented in the article and consider its conclusions invalid. The authors were informed of the retraction.
{"title":"RETRACTION: Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway","authors":"","doi":"10.1002/jcb.70016","DOIUrl":"https://doi.org/10.1002/jcb.70016","url":null,"abstract":"<p><b>RETRACTION:</b> P. Chen, S. Xu, and J. Qu, “Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway,” <i>Journal of Cellular Biochemistry</i> 119, no. 1 (2018): 366-377, https://doi.org/10.1002/jcb.26189.</p><p>The above article, published online on 6 June 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Multiple image elements within Figures 2 A and 4 A were found to have been published previously and/or subsequently by different authors in different scientific contexts. Furthermore, evidence of inappropriate image editing/manipulation were found within Figure 3 C. The authors were invited to comment on these concerns but did not respond. Accordingly, the article is retracted as the editors have lost confidence in the integrity and reliability of the full body of data presented in the article and consider its conclusions invalid. The authors were informed of the retraction.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RETRACTION: D. Sheipouri, R. Grant, S. Bustamante, D. Lovejoy, G. J. Guillemin, and N. Braidy, “Characterization of the Kynurenine Pathway in Skin-Derived Fibroblasts and Keratinocytes,” Journal of Cellular Biochemistry 116, no. 6 (2015): 903-922. https://doi.org/10.1002/jcb.25019.
The above article, published online on January 12, 2015, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl, and Wiley Periodicals LLC. The journal received notice from a third party regarding evidence of duplication and image manipulation between the QPRT and KMO panels in Figure 5D as well as the QPRT and KAT-II panels in Figure 5B. The publisher confirmed these duplications. Some authors responded to an inquiry by the publisher but were not able to provide an explanation for the duplicated panels and were not able to provide original data for verification. An initial investigation by the University of New South Wales Conduct & Integrity Office concluded that the immunochemistry data presented in this article had been misrepresented, fabricated and/or falsified and warranted further investigation by an independent research misconduct inquiry panel. The retraction has been agreed to because the evidence of image duplication and manipulation compromises the integrity of the study and the conclusions presented in the article. S.B. and D.L. agree with the retraction. All other authors did not respond to our notice regarding the retraction.
引用本文：D. Sheipouri， R. Grant， S. Bustamante， D. Lovejoy， G. J. Guillemin， N. Braidy，“皮肤源性成纤维细胞和角质形成细胞中犬尿氨酸途径的表征”，《细胞生物化学杂志》116，第1期。6(2015): 903-922。https://doi.org/10.1002/jcb.25019.The上述文章于2015年1月12日在线发表在Wiley online Library （wileyonlinelibrary.com）上，经期刊主编Christian Behl和Wiley期刊有限责任公司协议，该文章已被撤回。该期刊收到第三方通知，称有证据表明图5D中的QPRT和KMO图以及图5B中的QPRT和KAT-II图之间存在复制和图像操纵。出版商证实了这些重复。一些作者答复了出版商的询问，但无法对重复的面板作出解释，也无法提供原始数据供核查。新南威尔士大学的一项初步调查表明；诚信办公室的结论是，本文中提供的免疫化学数据被歪曲、捏造和/或伪造，有必要由一个独立的研究不端行为调查小组进行进一步调查。由于图像复制和篡改的证据损害了研究的完整性和文章中提出的结论，因此同意撤回。s。b。和d。l。同意撤回。所有其他作者都没有回应我们关于撤稿的通知。
{"title":"RETRACTION: Characterization of the Kynurenine Pathway in Skin-Derived Fibroblasts and Keratinocytes","authors":"","doi":"10.1002/jcb.70013","DOIUrl":"https://doi.org/10.1002/jcb.70013","url":null,"abstract":"<p><b>RETRACTION</b>: D. Sheipouri, R. Grant, S. Bustamante, D. Lovejoy, G. J. Guillemin, and N. Braidy, “Characterization of the Kynurenine Pathway in Skin-Derived Fibroblasts and Keratinocytes,” <i>Journal of Cellular Biochemistry</i> 116, no. 6 (2015): 903-922. https://doi.org/10.1002/jcb.25019.</p><p>The above article, published online on January 12, 2015, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl, and Wiley Periodicals LLC. The journal received notice from a third party regarding evidence of duplication and image manipulation between the QPRT and KMO panels in Figure 5D as well as the QPRT and KAT-II panels in Figure 5B. The publisher confirmed these duplications. Some authors responded to an inquiry by the publisher but were not able to provide an explanation for the duplicated panels and were not able to provide original data for verification. An initial investigation by the University of New South Wales Conduct & Integrity Office concluded that the immunochemistry data presented in this article had been misrepresented, fabricated and/or falsified and warranted further investigation by an independent research misconduct inquiry panel. The retraction has been agreed to because the evidence of image duplication and manipulation compromises the integrity of the study and the conclusions presented in the article. S.B. and D.L. agree with the retraction. All other authors did not respond to our notice regarding the retraction.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seithikurippu R. Pandi-Perumal, Konda Mani Saravanan, Sayan Paul, George C. Abraham, David Warren Spence, Saravana Babu Chidambaram
Sleep is a widespread and evolutionarily conserved process observed in diverse organisms, from jellyfish to mammals, hinting at its origin as a life-supporting mechanism over 500 million years ago. Although its fundamental purpose and mechanisms remain unclear, sleep's evolution and adaptive significance continue to be debated. This study explores the evolutionary origins of sleep using Chlamydomonas reinhardtii as a model organism, identifying 112 putative sleep-related genes across species and highlighting the evolutionary conservation of sleep-regulatory pathways. Additionally, discovering uncharacterized proteins with high sequence similarity and significant e-values suggests unexplored roles in sleep regulation, underscoring the potential of C. reinhardtii to reveal new insights into the molecular basis of sleep. This study provides a foundation for identifying previously unknown sleep-associated proteins, particularly within single-celled organisms, which may offer novel perspectives on the biological role of sleep. The study demonstrates that phylogenomic analysis of diverse model organisms can expand our understanding of the evolutionary trajectory of sleep and its fundamental function, paving the way for further research in sleep biology and its health implications. Overall, the fundamental functions of sleep observed in higher animal phyla originated from its primordial activities, demonstrating an evolutionary continuum wherein more specialized tasks were integrated with sleep's essential restorative properties.
{"title":"Cross-Kingdom Genomic Conservation of Putative Human Sleep-Related Genes: Phylogenomic Evidence From Chlamydomonas reinhardtii","authors":"Seithikurippu R. Pandi-Perumal, Konda Mani Saravanan, Sayan Paul, George C. Abraham, David Warren Spence, Saravana Babu Chidambaram","doi":"10.1002/jcb.70030","DOIUrl":"https://doi.org/10.1002/jcb.70030","url":null,"abstract":"<div>\u0000 \u0000 <p>Sleep is a widespread and evolutionarily conserved process observed in diverse organisms, from jellyfish to mammals, hinting at its origin as a life-supporting mechanism over 500 million years ago. Although its fundamental purpose and mechanisms remain unclear, sleep's evolution and adaptive significance continue to be debated. This study explores the evolutionary origins of sleep using <i>Chlamydomonas reinhardtii</i> as a model organism, identifying 112 putative sleep-related genes across species and highlighting the evolutionary conservation of sleep-regulatory pathways. Additionally, discovering uncharacterized proteins with high sequence similarity and significant e-values suggests unexplored roles in sleep regulation, underscoring the potential of <i>C. reinhardtii</i> to reveal new insights into the molecular basis of sleep. This study provides a foundation for identifying previously unknown sleep-associated proteins, particularly within single-celled organisms, which may offer novel perspectives on the biological role of sleep. The study demonstrates that phylogenomic analysis of diverse model organisms can expand our understanding of the evolutionary trajectory of sleep and its fundamental function, paving the way for further research in sleep biology and its health implications. Overall, the fundamental functions of sleep observed in higher animal phyla originated from its primordial activities, demonstrating an evolutionary continuum wherein more specialized tasks were integrated with sleep's essential restorative properties.</p>\u0000 </div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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