Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.022
Yanhua Mao, Weijun Cao
Objective To investigate the predictive value of peripheral blood eosinophil percentage (EOS%) and exhaled nitric oxide (FeNO) on the efficacy of inhaled corticosteroids (ICS) in patients with chronic obstructive pulmonary disease (COPD) at stable stage. Methods A total of 78 patients with stable COPD during the outpatient clinic from January 2017 to December 2018 were enrolled. EOS%, FeNO, and pulmonary function indicators [forced vital capacity(FVC), forced expiratory volume in 1 sec (FEV1), peak expiratory flow (PEF)] were measured after ICS-free elution. The questionnaire was used to assess the severity of the symptoms. The above indicators were reviewed after 4 weeks of ICS treatment. According to the improvement of pulmonary function and chronic obstructive pulmonary disease assessment (CAT) improvement , the patients were divided into effective and ineffective groups. Pearson correlation analysis and receiver operating characteristic (ROC) curve were used to analyze the predictive value of EOS% and FeNO for ICS. Results After ICS treatment, EOS% and FeNO were lower, FVC, FEV1, and PEF were higher than before, and CAT score was lower than before (P 0.05). The FeNO level in the effective group was higher than that in the ineffective group before and after ICS treatment, with statistically significant difference (P 0.05); the area under the ROC curve for EOS% prediction of ICS efficacy before treatment was 0.531 (P>0.05), with critical value 3.13%, the sensitivity 57.1% and specificity 52.4%, respectively. The area under the ROC curve of FeNO for ICS treatment before treatment was 0.628 (P<0.05), with critical value 30.00%, sensitivity and specificity (64.6% and 91.0%) respectively. Conclusions For patients with stable COPD, EOS% and FeNO levels are positively correlated with the improvement of FEV1 after ICS treatment. Both of them can predict the efficacy of ICS to a certain extent, and FeNO has higher predictive value than EOS%, which can be applied to clinical practice. Key words: Pulmonary disease, chronic obstructive; Eosinophils; Fractional exhaled nitric oxide; Inhaled glucocorticoid
{"title":"The predictive value of serum EOS% and FeNO in stable phase of COPD for the therapeutic effect of glucocorticoids","authors":"Yanhua Mao, Weijun Cao","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.022","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.022","url":null,"abstract":"Objective \u0000To investigate the predictive value of peripheral blood eosinophil percentage (EOS%) and exhaled nitric oxide (FeNO) on the efficacy of inhaled corticosteroids (ICS) in patients with chronic obstructive pulmonary disease (COPD) at stable stage. \u0000 \u0000 \u0000Methods \u0000A total of 78 patients with stable COPD during the outpatient clinic from January 2017 to December 2018 were enrolled. EOS%, FeNO, and pulmonary function indicators [forced vital capacity(FVC), forced expiratory volume in 1 sec (FEV1), peak expiratory flow (PEF)] were measured after ICS-free elution. The questionnaire was used to assess the severity of the symptoms. The above indicators were reviewed after 4 weeks of ICS treatment. According to the improvement of pulmonary function and chronic obstructive pulmonary disease assessment (CAT) improvement , the patients were divided into effective and ineffective groups. Pearson correlation analysis and receiver operating characteristic (ROC) curve were used to analyze the predictive value of EOS% and FeNO for ICS. \u0000 \u0000 \u0000Results \u0000After ICS treatment, EOS% and FeNO were lower, FVC, FEV1, and PEF were higher than before, and CAT score was lower than before (P 0.05). The FeNO level in the effective group was higher than that in the ineffective group before and after ICS treatment, with statistically significant difference (P 0.05); the area under the ROC curve for EOS% prediction of ICS efficacy before treatment was 0.531 (P>0.05), with critical value 3.13%, the sensitivity 57.1% and specificity 52.4%, respectively. The area under the ROC curve of FeNO for ICS treatment before treatment was 0.628 (P<0.05), with critical value 30.00%, sensitivity and specificity (64.6% and 91.0%) respectively. \u0000 \u0000 \u0000Conclusions \u0000For patients with stable COPD, EOS% and FeNO levels are positively correlated with the improvement of FEV1 after ICS treatment. Both of them can predict the efficacy of ICS to a certain extent, and FeNO has higher predictive value than EOS%, which can be applied to clinical practice. \u0000 \u0000 \u0000Key words: \u0000Pulmonary disease, chronic obstructive; Eosinophils; Fractional exhaled nitric oxide; Inhaled glucocorticoid","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74282802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.018
Jie Shen, B. Dai
Objective To explore the effects of irbesartan combined with hemodialysis on renal function, inflammatory factors and renal hemodynamics in patients with renal proteinuria. Methods A total of 106 patients with renal proteinuria who underwent hemodialysis in Changzheng Hospital Affiliated to Naval Medical University from May 2016 to May 2018 were selected for the study and were divided into observation group and control group according to the random number table method. The two groups were given hemodialysis, and observation group was given irbesartan on this basis. Kidney-related examination indexes [24 h urine protein quantitation, 24 h urine volume, serum creatinine (Scr), urea nitrogen (BUN)], inflammatory factors [C-reactive protein (CRP), interleukin-8 (IL-8), intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1)], bilateral renal interlobar artery resistance index (RI), hemorheology (whole blood viscosity, low-shear viscosity, high-shear viscosity, erythrocyte aggregation index) were observed in the two groups before and after treatment. Results After 3 months of treatment, the levels of urine protein quantitation, serum Scr, BUN, CRP, IL-8, ICAM-1 and MCP-1 in the two groups were lower than those before treatment, and the levels in observation group were lower than those in control group (P<0.05); the 24h urine volume was more than that before treatment, and the level in observation group was more than that in control group (P<0.05). The RI values of bilateral kidney in the two groups were lower than those before treatment, and the value in observation group was lower than that in control group (P<0.05). The whole blood viscosity, low-shear viscosity, high-shear viscosity and erythrocyte aggregation index in the two groups were lower than those before treatment, and the indexes in observation group were lower than those in control group (P<0.05). Conclusions Addition of irbesartan in patients with renal proteinuria treated by hemodialysis can effectively improve renal function, reduce inflammation and blood viscosity, and improve renal hemodynamics, and promote the disease outcomes. Key words: Irbesartan; Hemodialysis; Renal proteinyria; Hemodynamics
{"title":"Effect of irbesartan combined with hemodialysis on renal hemodynamics in patients with renal proteinuria","authors":"Jie Shen, B. Dai","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.018","url":null,"abstract":"Objective \u0000To explore the effects of irbesartan combined with hemodialysis on renal function, inflammatory factors and renal hemodynamics in patients with renal proteinuria. \u0000 \u0000 \u0000Methods \u0000A total of 106 patients with renal proteinuria who underwent hemodialysis in Changzheng Hospital Affiliated to Naval Medical University from May 2016 to May 2018 were selected for the study and were divided into observation group and control group according to the random number table method. The two groups were given hemodialysis, and observation group was given irbesartan on this basis. Kidney-related examination indexes [24 h urine protein quantitation, 24 h urine volume, serum creatinine (Scr), urea nitrogen (BUN)], inflammatory factors [C-reactive protein (CRP), interleukin-8 (IL-8), intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1)], bilateral renal interlobar artery resistance index (RI), hemorheology (whole blood viscosity, low-shear viscosity, high-shear viscosity, erythrocyte aggregation index) were observed in the two groups before and after treatment. \u0000 \u0000 \u0000Results \u0000After 3 months of treatment, the levels of urine protein quantitation, serum Scr, BUN, CRP, IL-8, ICAM-1 and MCP-1 in the two groups were lower than those before treatment, and the levels in observation group were lower than those in control group (P<0.05); the 24h urine volume was more than that before treatment, and the level in observation group was more than that in control group (P<0.05). The RI values of bilateral kidney in the two groups were lower than those before treatment, and the value in observation group was lower than that in control group (P<0.05). The whole blood viscosity, low-shear viscosity, high-shear viscosity and erythrocyte aggregation index in the two groups were lower than those before treatment, and the indexes in observation group were lower than those in control group (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Addition of irbesartan in patients with renal proteinuria treated by hemodialysis can effectively improve renal function, reduce inflammation and blood viscosity, and improve renal hemodynamics, and promote the disease outcomes. \u0000 \u0000 \u0000Key words: \u0000Irbesartan; Hemodialysis; Renal proteinyria; Hemodynamics","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77910537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.007
Qing Liu, Kaijiang Liu
Since 2018, the controversy between laparotomy and minimally invasive surgery for cervical cancer has been paid attention widespread, In addition, we should analyze the other problems in cervical cancer surgery objectively and comprehensively. Laparoscopic surgery has been rapidly popularized in China due to its advantages over the past 10 years. However, there are still many points in the treatment of cervical cancer in China, such as not paying attention to the concept of tumor-free, not strictly grasping the indications for surgery, inadequate surgical scope, and lack of oncologist training, etc, which needs we pay more attention. In order to obtain the best therapeutic effect, we not only pay attention to the discuss of laparotomy and minimally invasive of the cervical cancer, but should also pay attention to the nature of tumor treatment. Key words: Uterine cervical neoplasms; Laparotomy; Laparoscopy
{"title":"Rethinking the controversy between laparotomy and laparoscopy in cervical cancer surgery","authors":"Qing Liu, Kaijiang Liu","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.007","url":null,"abstract":"Since 2018, the controversy between laparotomy and minimally invasive surgery for cervical cancer has been paid attention widespread, In addition, we should analyze the other problems in cervical cancer surgery objectively and comprehensively. Laparoscopic surgery has been rapidly popularized in China due to its advantages over the past 10 years. However, there are still many points in the treatment of cervical cancer in China, such as not paying attention to the concept of tumor-free, not strictly grasping the indications for surgery, inadequate surgical scope, and lack of oncologist training, etc, which needs we pay more attention. In order to obtain the best therapeutic effect, we not only pay attention to the discuss of laparotomy and minimally invasive of the cervical cancer, but should also pay attention to the nature of tumor treatment. \u0000 \u0000Key words: \u0000Uterine cervical neoplasms; Laparotomy; Laparoscopy","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87169943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.005
Gong Yuan, Huimin Zhang, Fei Gou, Jun Wang, Caihong Liu, Donglin Li
Objective To evaluate the value of colposcopy screening independently for cervical lesions in basic hospitals. Methods A retrospective cohort study of 574 patients who both underwent colposcopy and had pathologic results in our department. The consistency, authenticity and predictability of colposcopy and pathological results, the relevant factors affecting the accuracy of colposcopy diagnosis, and the analysis of unsatisfactory colposcopy results were analyzed. Results Agreement between colposcopic diagnosis and cervical pathology was 50.57%, and Kappa value of consistency was 0.358 (P<0.01). Agreement within one grade was 91.38 % (Kappa value was 0.871, P<0.01). The sensitivity of colposcopy in diagnosing of low-grade squamous intraepithelial lesion (LSIL) and above was high (96.91%), while the specificity was 52.60% (81/154); False positive rate was 47.40%, and false negative rate was 3.09%. The sensitivity of colposcopy in diagnosing of high-grade squamous intraepithelial lesion (HSIL) and above was 81.82% (153/187), and the specificity in diagnosing of LSIL and below was 90.68% (146/161); False positive rate was 9.3%, and false negative rate was 18.2%. The stage of cervical cancer and skills of colposcopist would be factors that influence the accuracy of colposcopy screening in HSIL and above (P<0.01). Average age in unsatisfactory colposcopy was (52±9)y, which was significantly different from satisfactory colposcopy cases (P<0.01). The proportion of early cervical lesions in patients with unsatisfactory colposcopy HSIL or above was high. Conclusions The complete coincidence rate between colposcopy and pathological diagnosis is limited, but the consistency within one grade is good; the stage of cervical lesions and the experience of examiners are the factors related to the accuracy of colposcopy in diagnosing HSIL and above lesions; Unsatisfactory colposcopy cases can be further combined with cytology and HPV examination for shunt and treatment. Key words: Colposcopy; Uterine cervical diseases; Sensitivity and specificity
{"title":"Value of colposcopy screening independently for cervical lesions in basic hospitals","authors":"Gong Yuan, Huimin Zhang, Fei Gou, Jun Wang, Caihong Liu, Donglin Li","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.005","url":null,"abstract":"Objective To evaluate the value of colposcopy screening independently for cervical lesions in basic hospitals. Methods A retrospective cohort study of 574 patients who both underwent colposcopy and had pathologic results in our department. The consistency, authenticity and predictability of colposcopy and pathological results, the relevant factors affecting the accuracy of colposcopy diagnosis, and the analysis of unsatisfactory colposcopy results were analyzed. Results Agreement between colposcopic diagnosis and cervical pathology was 50.57%, and Kappa value of consistency was 0.358 (P<0.01). Agreement within one grade was 91.38 % (Kappa value was 0.871, P<0.01). The sensitivity of colposcopy in diagnosing of low-grade squamous intraepithelial lesion (LSIL) and above was high (96.91%), while the specificity was 52.60% (81/154); False positive rate was 47.40%, and false negative rate was 3.09%. The sensitivity of colposcopy in diagnosing of high-grade squamous intraepithelial lesion (HSIL) and above was 81.82% (153/187), and the specificity in diagnosing of LSIL and below was 90.68% (146/161); False positive rate was 9.3%, and false negative rate was 18.2%. The stage of cervical cancer and skills of colposcopist would be factors that influence the accuracy of colposcopy screening in HSIL and above (P<0.01). Average age in unsatisfactory colposcopy was (52±9)y, which was significantly different from satisfactory colposcopy cases (P<0.01). The proportion of early cervical lesions in patients with unsatisfactory colposcopy HSIL or above was high. Conclusions The complete coincidence rate between colposcopy and pathological diagnosis is limited, but the consistency within one grade is good; the stage of cervical lesions and the experience of examiners are the factors related to the accuracy of colposcopy in diagnosing HSIL and above lesions; Unsatisfactory colposcopy cases can be further combined with cytology and HPV examination for shunt and treatment. Key words: Colposcopy; Uterine cervical diseases; Sensitivity and specificity","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85338596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.011
Zhongchen Li, Cuhang Chen, Jia-Zheng Jin
Objective To investigate the inhibitory effect of harmine on osteosarcoma cell proliferation and apoptosis by down regulating cyclooxygenase-2 (COX-2) expression. Methods Human osteosarcoma cell line U2OS was cultured in vitro and randomly divided into control group, study group 1, study group 2 and study group 3. The cells were cultured in 0, 5 μmol/L, 10 μmol/L and 20 μmol/L concentration of harmine for 48 hours. Cell counting kit-8 (CCK-8) method and flow cytometry were used to detect cell viability and apoptosis. The expression level of COX-2, proliferation and apoptosis related proteins and mRNA were detected by Western blot and real-time quantitative polymerase chain reaction (RT-qPCR), respectively. Results After cultured with different concentrations of harmine for 12, 24 hours and 48 hours, the cell viability of the three study groups were significantly lower than that of the control group (P<0.05), while that of the study groups 2 and 3 were significantly lower than that of the study group 1 (P<0.05). The apoptosis rate of the three study groups were significantly higher than that of the control group (P<0.05), while that of the two groups were significantly higher than that of the study group 1 (P<0.05). After 48 hours of culture, the levels of COX-2, cyclin D1, proliferating cell nuclear antigen (PCNA), B-cell lymphoma-2 (Bcl-2) protein and mRNA expression in study group 2 were significantly lower than those in control group, while the expression levels of cleaved caspase-3 and BCL2-Associated X (Bax) in study group 2 were significantly higher than those in control group (P<0.05) . Conclusions Harmine can inhibit the proliferation and promote the apoptosis of osteosarcoma cells by inhibiting the expression of COX-2 and regulating the expression of cell cycle and apoptosis related protein. Key words: Cyclooxygenase 2; Harmine; Osteosarcoma; Cell line, tumor
{"title":"Effect of harmine on osteosarcoma cell proliferation and apoptosis by down regulating COX-2 expression","authors":"Zhongchen Li, Cuhang Chen, Jia-Zheng Jin","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.011","url":null,"abstract":"Objective \u0000To investigate the inhibitory effect of harmine on osteosarcoma cell proliferation and apoptosis by down regulating cyclooxygenase-2 (COX-2) expression. \u0000 \u0000 \u0000Methods \u0000Human osteosarcoma cell line U2OS was cultured in vitro and randomly divided into control group, study group 1, study group 2 and study group 3. The cells were cultured in 0, 5 μmol/L, 10 μmol/L and 20 μmol/L concentration of harmine for 48 hours. Cell counting kit-8 (CCK-8) method and flow cytometry were used to detect cell viability and apoptosis. The expression level of COX-2, proliferation and apoptosis related proteins and mRNA were detected by Western blot and real-time quantitative polymerase chain reaction (RT-qPCR), respectively. \u0000 \u0000 \u0000Results \u0000After cultured with different concentrations of harmine for 12, 24 hours and 48 hours, the cell viability of the three study groups were significantly lower than that of the control group (P<0.05), while that of the study groups 2 and 3 were significantly lower than that of the study group 1 (P<0.05). The apoptosis rate of the three study groups were significantly higher than that of the control group (P<0.05), while that of the two groups were significantly higher than that of the study group 1 (P<0.05). After 48 hours of culture, the levels of COX-2, cyclin D1, proliferating cell nuclear antigen (PCNA), B-cell lymphoma-2 (Bcl-2) protein and mRNA expression in study group 2 were significantly lower than those in control group, while the expression levels of cleaved caspase-3 and BCL2-Associated X (Bax) in study group 2 were significantly higher than those in control group (P<0.05) . \u0000 \u0000 \u0000Conclusions \u0000Harmine can inhibit the proliferation and promote the apoptosis of osteosarcoma cells by inhibiting the expression of COX-2 and regulating the expression of cell cycle and apoptosis related protein. \u0000 \u0000 \u0000Key words: \u0000Cyclooxygenase 2; Harmine; Osteosarcoma; Cell line, tumor","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81655801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.016
Juhua Chen, Yili Wang, Hongwei H Zhang
Objective To analyze the changes of Survivin, MSH6 and MSH2 expression in colorectal cancer and explore their relationship with clinical and pathological parameters. Methods 197 cases of colorectal adenocarcinoma and 20 cases of inflammatory intestinal mucosa were detected by immunohistochemistry with Survivin, MSH6 and MSH2, and the correlation between Survivin, MSH6 and MSH2 expression was analyzed. Results In the control group of 20 cases with inflammatory non-tumor intestinal mucosa, the positive expression rate of MSH2, MSH6, Survivin were 95%, 95%, 10%, respectively. While the positive expression rate of MSH2, MSH6, Survivin were 88.3%, 74.1% and 84.3% in 197 cases of colorectal cancer. Survivin positive expression rate in colorectal cancer group was significantly higher than that in inflammatory control group (P 0.05). MSH2 expression was correlated with tumor size and lymph node metastasis (P 0.05). MSH6 expression was related to gender and lymph node metastasis (P 0.05). Colorectal cancer tissues showed positive correlation between MSH6 and MSH2 (r=0.326, P<0.01), positive correlation between MSH2 and Survivin positive expression (r=0.277, P<0.01), and positive correlation between MSH6 and Survivin positive expression (r=0.435, P<0.01). Conclusions The positive expression rate of Survivin in colorectal cancer is high. MSH2, MSH6 and Survivin in colorectal cancer play an important role in the development and progression of colorectal cancer, and can provide evidence for the detection of these three factors, including metastasis risk, prognosis assessment and clinical treatment. In particular, Survivin gene may provide evidence for gene therapy. Key words: Colorectal neoplasms; MutS homolog 2 protein; MutS homolog 6 protein; Survivin
{"title":"Expression and its clinicopathological significance of Survivin, MSH2 and MSH6 in colorectal cancer","authors":"Juhua Chen, Yili Wang, Hongwei H Zhang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.016","url":null,"abstract":"Objective \u0000To analyze the changes of Survivin, MSH6 and MSH2 expression in colorectal cancer and explore their relationship with clinical and pathological parameters. \u0000 \u0000 \u0000Methods \u0000197 cases of colorectal adenocarcinoma and 20 cases of inflammatory intestinal mucosa were detected by immunohistochemistry with Survivin, MSH6 and MSH2, and the correlation between Survivin, MSH6 and MSH2 expression was analyzed. \u0000 \u0000 \u0000Results \u0000In the control group of 20 cases with inflammatory non-tumor intestinal mucosa, the positive expression rate of MSH2, MSH6, Survivin were 95%, 95%, 10%, respectively. While the positive expression rate of MSH2, MSH6, Survivin were 88.3%, 74.1% and 84.3% in 197 cases of colorectal cancer. Survivin positive expression rate in colorectal cancer group was significantly higher than that in inflammatory control group (P 0.05). MSH2 expression was correlated with tumor size and lymph node metastasis (P 0.05). MSH6 expression was related to gender and lymph node metastasis (P 0.05). Colorectal cancer tissues showed positive correlation between MSH6 and MSH2 (r=0.326, P<0.01), positive correlation between MSH2 and Survivin positive expression (r=0.277, P<0.01), and positive correlation between MSH6 and Survivin positive expression (r=0.435, P<0.01). \u0000 \u0000 \u0000Conclusions \u0000The positive expression rate of Survivin in colorectal cancer is high. MSH2, MSH6 and Survivin in colorectal cancer play an important role in the development and progression of colorectal cancer, and can provide evidence for the detection of these three factors, including metastasis risk, prognosis assessment and clinical treatment. In particular, Survivin gene may provide evidence for gene therapy. \u0000 \u0000 \u0000Key words: \u0000Colorectal neoplasms; MutS homolog 2 protein; MutS homolog 6 protein; Survivin","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87805228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.008
Yupei Ren, Kun Wang, Yating Ma, Ka-te Huang, B. Yi
Objective To explore the relationship between urinary iodine level and breast cancer, we compare urinary iodine excretion levels in patients with breast cancer, benign breast disease, other female malignant tumors and control subjects in Xiangya Hospital of Central South University. Methods From December 2018 to January 2019, 64 patients with newly diagnosed breast cancer in Xiangya Hospital of Central South University were selected as case group, benign breast disease group (n=49), other female malignant tumor group (n=39) and health examination group (n=50) as control group. Urinary iodine was determined by colorimetry. According to the urinary iodine level the patients divided into three groups: iodine excess (>300 μg/L), medium iodine (100-300 μg/L) and iodine deficiency (<100 μg/L). The relationship between urinary iodine and clinicopathology of breast cancer was analyzed. Results The level of urinary iodine in benign breast nodule group 319.13(163.98)μg/L > breast cancer group 273.96(151.30)μg/L > female other malignant tumor group 212.95(161.71)μg/L > normal control group 199.15(194.45)μg/L, with significantly differance (H=9.936, P=0.019). Urinary iodine level in the normal control group was significantly lower than that in the benign breast disease group (P=0.013). The patients were further divided into three groups according to the urinary iodine level: iodine excess, iodine medium and iodine deficiency, the number of urine iodine <100 μg/L in the normal control group was significantly higher than that in the breast cancer group (P=0.021). The level of urinary iodine was negatively correlated with the size of the primary focus of breast cancer (Z=-2.307, P=0.021). The effect of urinary iodine was analyzed by multiple linear regression method. The size of primary focus was included in the regression equation (R2=0.136 , P=0.007), but had nothing to do with lymph node metastasis and the expression status of estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2). Conclusions There is a negative linear correlation between urinary iodine level and the size of primary focus of breast cancer, but it has nothing to do with lymph node metastasis and the expression of ER, AR, PR and HER-2. Key words: Breast neoplasms; Urinary iodine; Sodium iodine symporters
{"title":"Correlation between urinary iodine and clinical characteristics in breast cancer","authors":"Yupei Ren, Kun Wang, Yating Ma, Ka-te Huang, B. Yi","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.008","url":null,"abstract":"Objective \u0000To explore the relationship between urinary iodine level and breast cancer, we compare urinary iodine excretion levels in patients with breast cancer, benign breast disease, other female malignant tumors and control subjects in Xiangya Hospital of Central South University. \u0000 \u0000 \u0000Methods \u0000From December 2018 to January 2019, 64 patients with newly diagnosed breast cancer in Xiangya Hospital of Central South University were selected as case group, benign breast disease group (n=49), other female malignant tumor group (n=39) and health examination group (n=50) as control group. Urinary iodine was determined by colorimetry. According to the urinary iodine level the patients divided into three groups: iodine excess (>300 μg/L), medium iodine (100-300 μg/L) and iodine deficiency (<100 μg/L). The relationship between urinary iodine and clinicopathology of breast cancer was analyzed. \u0000 \u0000 \u0000Results \u0000The level of urinary iodine in benign breast nodule group 319.13(163.98)μg/L > breast cancer group 273.96(151.30)μg/L > female other malignant tumor group 212.95(161.71)μg/L > normal control group 199.15(194.45)μg/L, with significantly differance (H=9.936, P=0.019). Urinary iodine level in the normal control group was significantly lower than that in the benign breast disease group (P=0.013). The patients were further divided into three groups according to the urinary iodine level: iodine excess, iodine medium and iodine deficiency, the number of urine iodine <100 μg/L in the normal control group was significantly higher than that in the breast cancer group (P=0.021). The level of urinary iodine was negatively correlated with the size of the primary focus of breast cancer (Z=-2.307, P=0.021). The effect of urinary iodine was analyzed by multiple linear regression method. The size of primary focus was included in the regression equation (R2=0.136 , P=0.007), but had nothing to do with lymph node metastasis and the expression status of estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2). \u0000 \u0000 \u0000Conclusions \u0000There is a negative linear correlation between urinary iodine level and the size of primary focus of breast cancer, but it has nothing to do with lymph node metastasis and the expression of ER, AR, PR and HER-2. \u0000 \u0000 \u0000Key words: \u0000Breast neoplasms; Urinary iodine; Sodium iodine symporters","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75766592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.042
Long Yuan, Xuesong Li, Chunyang Meng, Hongmei Liu
Neuropathic pain (NP) is pain triggered or caused by primary damage and dysfunction of the nervous system. It belongs to a kind of chronic pain, which is manifested as spontaneous pain, hyperalgesia, abnormal pain, paresthesia and other clinical characteristics. Because the pathogenesis is not clear, the therapeutic effect is not satisfactory. After nerve injury, the glial cells in the injured site and dorsal root ganglia (DRG) release various inflammatory mediators to participate in the regulation of the transmission of damaging information. The inflammatory process of neuropathic pain may be accomplished through some signaling pathways. This article reviews the current research on the relationship between inflammation and neuropathic pain. Key words: Inflammation; Inflammatory mediators; Neuropathic pain; Signal transduction; Review
{"title":"Research progress on the relationship between inflammation and neuropathic pain","authors":"Long Yuan, Xuesong Li, Chunyang Meng, Hongmei Liu","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.042","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.042","url":null,"abstract":"Neuropathic pain (NP) is pain triggered or caused by primary damage and dysfunction of the nervous system. It belongs to a kind of chronic pain, which is manifested as spontaneous pain, hyperalgesia, abnormal pain, paresthesia and other clinical characteristics. Because the pathogenesis is not clear, the therapeutic effect is not satisfactory. After nerve injury, the glial cells in the injured site and dorsal root ganglia (DRG) release various inflammatory mediators to participate in the regulation of the transmission of damaging information. The inflammatory process of neuropathic pain may be accomplished through some signaling pathways. This article reviews the current research on the relationship between inflammation and neuropathic pain. \u0000 \u0000Key words: \u0000Inflammation; Inflammatory mediators; Neuropathic pain; Signal transduction; Review","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75562553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.009
Heng Li, W. Weng, Hong-hang Yang, Zhenguo Sun
Objective To systematic evaluate the curative effect of total hip arthroplasty (THA) through direct anterior approach versus (DAA) posterolateral approach (PSA). Methods All the randomized controlled trial (RCT) articles and observational research articles about the curative effect of THA through direct anterior approach (DAA group) versus posterolateral approach (PSA group)for treatment of hip disease that published at home and abroad included from database establishing to December 2017 were retrieved from Cochrane Library, Pubmed, Web of Science, CBM and China national knowledge internet (CNKI) through computer. The articles were screened and the information was extracted independently by two authors. A Meta-analysis was performed utilizing the RevMan 5.3 software. Results Two hundred and forty-nine articles were searched out in the initial stage. After screening, 7 Chinese articles and 2 English articles (942 cases)were included in the final analysis, including 8 RCT articles and 1 observational research article, and 463 patients in direct anterior approach and 479 patients in posterolateral approach. The results of Meta-analysis demonstrated that the incision length, operation time, intraoperative blood less, Harris hip function scores at 1 month after surgery, visual analogue scale (VAS) scores at 24 hours after surgery, postoperative bed rest time and the hospital stay were better in DAA group compared to PSA group (SMD=-2.51, 95% CI: -4.84, -0.19, P=0.03); (SMD=0.84, 95% CI: 0.10, 1.59, P=0.03); (SMD=-1.52, 95% CI: -2.98, -0.05, P=0.04); (SMD=2.58, 95% CI: 0.65, 4.51, P=0.009); (SMD=-0.65, 95% CI: -0.91, -0.38, P<0.01); (SMD=-1.85, 95% CI: -3.00, -0.70, P=0.002); (SMD=-1.12, 95% CI: -1.62, -0.61, P<0.01). There were no statistical difference in drainage (SMD=-1.45, 95% CI: -3.40, 0.49, P=0.14), Harris hip function scores at last follow-up (SMD=0.91, 95% CI: -0.31, 2.14, P=0.15), VAS scores at 48 hours after surgery (SMD=-1.21, 95% CI: -3.03, 0.61, P=0.19), acetabular anteversion angles (SMD=-0.50, 95% CI: -1.06, 0.05, P=0.07), acetabular abduction angles (SMD=-0.01, 95% CI: -0.32, 0.30, P=0.97) and incidence of complications (OR=1.10, 95% CI: 0.59, 2.07, P=0.77) between the 2 groups. The result of analysis of publication bias according to Harris hip function scores at last follow-up and incidence of complications showed that the funnel-plot was essentially bilateral symmetry. Conclusions THA through DAA can significantly reduce the soft-tissue damage, and it is beneficial for patient's quick recovery, also it conforms to the current concept of minimally invasive treatment that worthy of promotion. Key words: Arthroplasty, replacement, hip; Meta-analysis
{"title":"Systematic review on the curative effect of total hip arthroplasty through direct anterior approach versus posterolateral Approach","authors":"Heng Li, W. Weng, Hong-hang Yang, Zhenguo Sun","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.009","url":null,"abstract":"Objective \u0000To systematic evaluate the curative effect of total hip arthroplasty (THA) through direct anterior approach versus (DAA) posterolateral approach (PSA). \u0000 \u0000 \u0000Methods \u0000All the randomized controlled trial (RCT) articles and observational research articles about the curative effect of THA through direct anterior approach (DAA group) versus posterolateral approach (PSA group)for treatment of hip disease that published at home and abroad included from database establishing to December 2017 were retrieved from Cochrane Library, Pubmed, Web of Science, CBM and China national knowledge internet (CNKI) through computer. The articles were screened and the information was extracted independently by two authors. A Meta-analysis was performed utilizing the RevMan 5.3 software. \u0000 \u0000 \u0000Results \u0000Two hundred and forty-nine articles were searched out in the initial stage. After screening, 7 Chinese articles and 2 English articles (942 cases)were included in the final analysis, including 8 RCT articles and 1 observational research article, and 463 patients in direct anterior approach and 479 patients in posterolateral approach. The results of Meta-analysis demonstrated that the incision length, operation time, intraoperative blood less, Harris hip function scores at 1 month after surgery, visual analogue scale (VAS) scores at 24 hours after surgery, postoperative bed rest time and the hospital stay were better in DAA group compared to PSA group (SMD=-2.51, 95% CI: -4.84, -0.19, P=0.03); (SMD=0.84, 95% CI: 0.10, 1.59, P=0.03); (SMD=-1.52, 95% CI: -2.98, -0.05, P=0.04); (SMD=2.58, 95% CI: 0.65, 4.51, P=0.009); (SMD=-0.65, 95% CI: -0.91, -0.38, P<0.01); (SMD=-1.85, 95% CI: -3.00, -0.70, P=0.002); (SMD=-1.12, 95% CI: -1.62, -0.61, P<0.01). There were no statistical difference in drainage (SMD=-1.45, 95% CI: -3.40, 0.49, P=0.14), Harris hip function scores at last follow-up (SMD=0.91, 95% CI: -0.31, 2.14, P=0.15), VAS scores at 48 hours after surgery (SMD=-1.21, 95% CI: -3.03, 0.61, P=0.19), acetabular anteversion angles (SMD=-0.50, 95% CI: -1.06, 0.05, P=0.07), acetabular abduction angles (SMD=-0.01, 95% CI: -0.32, 0.30, P=0.97) and incidence of complications (OR=1.10, 95% CI: 0.59, 2.07, P=0.77) between the 2 groups. The result of analysis of publication bias according to Harris hip function scores at last follow-up and incidence of complications showed that the funnel-plot was essentially bilateral symmetry. \u0000 \u0000 \u0000Conclusions \u0000THA through DAA can significantly reduce the soft-tissue damage, and it is beneficial for patient's quick recovery, also it conforms to the current concept of minimally invasive treatment that worthy of promotion. \u0000 \u0000 \u0000Key words: \u0000Arthroplasty, replacement, hip; Meta-analysis","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82378849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
At present, the prevention and control of the COVID-19 is still severe, its pathogen SARS-CoV-2 is highly infectious and pathogenic, and the population is generally susceptible. In order to deal with the epidemic, selective operation can be postponed, but most of the patients with acute abdominal diseases are commonly in clinic, with acute onset and severe condition, and most of them are accompanied with fever and gastrointestinal symptoms, so emergency operation is needed.Under the condition of the current epidemic—COVID-19, it requires a higher standard to diagnose and treat patients with acute abdomen. The first step is to carry out procedures to identify whether the patient is infected or not. Those who are not infected can go through the normal treating procedures.For patients diagnosed with COVID-19 or suspected patients, the second step is to achieve classified diagnoses and treatments, and to adopt a treating plan that integrates TCM and western medicine.In order to protect patients and medical staff, the COVID-19 in hospital transmission must be avoided. For patients with COVID-19 who need emergency surgery, we must strictly comply with the hospital's protection regulations, closely coordinate the relevant departments of surgery, perform the three-level protection, operate in accordance with the principle of damage control in the negative pressure surgery room, and return to the isolation ward according to the prevention and control process after operation. For units without surgical conditions, patients should be transferred to hospital in time on the premise of maximum damage control, and patients must not be delayed for timely diagnosis and treatment due to the epidemic. Key words: novel coronavirus; pneumonia; viral; acute abdominal diseases; Traditional Chinese and Western Medicine
{"title":"Prevention and treatment strategies of Traditional Chinese and Western Medicine for acute abdomen during the outbreak of COVID-19/ 中国医师杂志","authors":"Guolei Li, Guoliang Tan, Yuan-hua Liu, Zhu Xu, H. Feng, Yali Zhang, Wei-Hong Xing, Zhi-feng Xu","doi":"10.3760/CMA.J.CN431274-20200221-00168","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20200221-00168","url":null,"abstract":"At present, the prevention and control of the COVID-19 is still severe, its pathogen SARS-CoV-2 is highly infectious and pathogenic, and the population is generally susceptible. In order to deal with the epidemic, selective operation can be postponed, but most of the patients with acute abdominal diseases are commonly in clinic, with acute onset and severe condition, and most of them are accompanied with fever and gastrointestinal symptoms, so emergency operation is needed.Under the condition of the current epidemic—COVID-19, it requires a higher standard to diagnose and treat patients with acute abdomen. The first step is to carry out procedures to identify whether the patient is infected or not. Those who are not infected can go through the normal treating procedures.For patients diagnosed with COVID-19 or suspected patients, the second step is to achieve classified diagnoses and treatments, and to adopt a treating plan that integrates TCM and western medicine.In order to protect patients and medical staff, the COVID-19 in hospital transmission must be avoided. For patients with COVID-19 who need emergency surgery, we must strictly comply with the hospital's protection regulations, closely coordinate the relevant departments of surgery, perform the three-level protection, operate in accordance with the principle of damage control in the negative pressure surgery room, and return to the isolation ward according to the prevention and control process after operation. For units without surgical conditions, patients should be transferred to hospital in time on the premise of maximum damage control, and patients must not be delayed for timely diagnosis and treatment due to the epidemic. \u0000 \u0000Key words: \u0000novel coronavirus; pneumonia; viral; acute abdominal diseases; Traditional Chinese and Western Medicine","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90544512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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