Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20191231-01491
Jianfei Xie, Lu Wang, Panpan Xiao, Lijun Li, Siqi He, Jianda Zhou, Qian Sun, S. Andy
Circadian rhythm disorder is a common physiological change of cancer survivors, which is mainly manifested in rest activity rhythm change, sleep wake disorder and the decrease of sleep efficiency at night, which further affect their physiological, psychological outcome and disease outcome. This paper reviews the concept, mechanism, influence and intervention methods of circadian rhythm disorder in cancer patients, in order to provide references for effective intervention of circadian rhythm disorder in cancer survivors. Key words: Neoplasms; Survivors; Circadian rhythm; Review
{"title":"Research progress of circadian rhythm disorder in cancer survivors","authors":"Jianfei Xie, Lu Wang, Panpan Xiao, Lijun Li, Siqi He, Jianda Zhou, Qian Sun, S. Andy","doi":"10.3760/CMA.J.CN431274-20191231-01491","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20191231-01491","url":null,"abstract":"Circadian rhythm disorder is a common physiological change of cancer survivors, which is mainly manifested in rest activity rhythm change, sleep wake disorder and the decrease of sleep efficiency at night, which further affect their physiological, psychological outcome and disease outcome. This paper reviews the concept, mechanism, influence and intervention methods of circadian rhythm disorder in cancer patients, in order to provide references for effective intervention of circadian rhythm disorder in cancer survivors. \u0000 \u0000Key words: \u0000Neoplasms; Survivors; Circadian rhythm; Review","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84349128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20181115-02089
Jing Gu, Lu Gao
Objective To explore the efficacy of salmon calcitonin combined with vitamin D3 in the treatment of chronic renal insufficiency and secondary hyperthyroidism and its effects on bone calcium metabolism. Methods A total of 40 patients with chronic renal failure who underwent hemodialysis in our blood purification center from September 2017 to December 2017 were selected for the study and were divided into treatment group (20 cases) and control group (20 cases) according to the random number table method. Patients in control group were given conventional treatment + calcitriol orally, and patients in treatment group were given subcutaneous injection of salmon calcitonin on the basis of control group. The course of treatment in both groups was 12 weeks. The clinical efficacy and clinical symptoms improvement, serum calcium, serum phosphorus and parathyroid hormone (iPTH) as well as the adverse reactions were compared between the two groups. The Kidney Disease Targeted Areas (KDTA) and Visual Analogue Pain Score (VAS) were used to evaluate the patients' quality of life and bone pain. Results The effective rate in treatment group was significantly higher than that in control group (95.00% vs 65.00%) (P 0.05). Conclusions The treatment effect of salmon calcitonin combined with vitamin D3 on chronic renal insufficiency secondary hyperthyroidism is obvious, and the clinical symptoms such as bone pain are improved obviously. It is believed that salmon calcitonin is related to the regulation of calcium, phosphorus and bone metabolism. Key words: Renal insufficiency, chronic; Hyperparathyroidism, secondary; Salmon calcitonin; Vitamin D3
目的探讨鲑鱼降钙素联合维生素D3治疗慢性肾功能不全继发性甲亢的疗效及对骨钙代谢的影响。方法选取2017年9月至2017年12月在我院血液净化中心接受血液透析治疗的慢性肾衰竭患者40例，按随机数字表法分为治疗组(20例)和对照组(20例)。对照组患者给予常规治疗+口服骨化三醇，治疗组患者在对照组基础上皮下注射鲑鱼降钙素。两组疗程均为12周。比较两组患者的临床疗效及临床症状改善情况，血清钙、磷、甲状旁腺激素(iPTH)水平及不良反应。采用肾脏疾病靶区(KDTA)和视觉模拟疼痛评分(VAS)评估患者的生活质量和骨痛。结果治疗组有效率显著高于对照组(95.00% vs 65.00%) (P < 0.05)。结论三文鱼降钙素联合维生素D3治疗慢性肾功能不全继发性甲亢疗效明显，骨痛等临床症状明显改善。人们认为鲑鱼降钙素与钙、磷和骨代谢的调节有关。关键词:肾功能不全，慢性;甲状旁腺功能亢进,二级;鲑鱼降钙素;维生素D3
{"title":"Salmon calcitonin combined with vitamin D3 in the treatment of hyperparathyroidism secondary to chronic renal insufficiency","authors":"Jing Gu, Lu Gao","doi":"10.3760/CMA.J.CN431274-20181115-02089","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20181115-02089","url":null,"abstract":"Objective \u0000To explore the efficacy of salmon calcitonin combined with vitamin D3 in the treatment of chronic renal insufficiency and secondary hyperthyroidism and its effects on bone calcium metabolism. \u0000 \u0000 \u0000Methods \u0000A total of 40 patients with chronic renal failure who underwent hemodialysis in our blood purification center from September 2017 to December 2017 were selected for the study and were divided into treatment group (20 cases) and control group (20 cases) according to the random number table method. Patients in control group were given conventional treatment + calcitriol orally, and patients in treatment group were given subcutaneous injection of salmon calcitonin on the basis of control group. The course of treatment in both groups was 12 weeks. The clinical efficacy and clinical symptoms improvement, serum calcium, serum phosphorus and parathyroid hormone (iPTH) as well as the adverse reactions were compared between the two groups. The Kidney Disease Targeted Areas (KDTA) and Visual Analogue Pain Score (VAS) were used to evaluate the patients' quality of life and bone pain. \u0000 \u0000 \u0000Results \u0000The effective rate in treatment group was significantly higher than that in control group (95.00% vs 65.00%) (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000The treatment effect of salmon calcitonin combined with vitamin D3 on chronic renal insufficiency secondary hyperthyroidism is obvious, and the clinical symptoms such as bone pain are improved obviously. It is believed that salmon calcitonin is related to the regulation of calcium, phosphorus and bone metabolism. \u0000 \u0000 \u0000Key words: \u0000Renal insufficiency, chronic; Hyperparathyroidism, secondary; Salmon calcitonin; Vitamin D3","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90292012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20200306-00240
Jian-Wei Li, Shu-guo Zheng, Li Cao
Laparoscopic hepatectomy has been gradually accepted by liver surgeons because of its advantages such as minimal invasive approach. However, laparoscopic hepatectomy in special liver segments ( Ⅰ, Ⅳa, Ⅶ, Ⅷ) isn't carried out due to difficult technology and high risk. In this paper, the operative strategies and key points of laparoscopic hepatectomy were discussed in special liver segments based on relevant literature and our own experience. Key words: Laparoscopy; Hepatectomy; Specific region
{"title":"Laparoscopic hepatectomy in special liver segments","authors":"Jian-Wei Li, Shu-guo Zheng, Li Cao","doi":"10.3760/CMA.J.CN431274-20200306-00240","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20200306-00240","url":null,"abstract":"Laparoscopic hepatectomy has been gradually accepted by liver surgeons because of its advantages such as minimal invasive approach. However, laparoscopic hepatectomy in special liver segments ( Ⅰ, Ⅳa, Ⅶ, Ⅷ) isn't carried out due to difficult technology and high risk. In this paper, the operative strategies and key points of laparoscopic hepatectomy were discussed in special liver segments based on relevant literature and our own experience. \u0000 \u0000Key words: \u0000Laparoscopy; Hepatectomy; Specific region","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83038029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Long non-coding RNAs (lncRNAs) are a kind of transcripts which are longer than 200nt and have not protein-coding ability due to the lack of an open reading frame. However, lncRNAs can be involved in tumorigenesis and progression in various ways at the transcriptional and post-transcriptional levels. Bladder cancer associated transcript 1 (BLACAT1) as a lncRNA located on human chromosome 1q32.1, is ectopic expression in various tumors (bladder cancer, gastric malignant tumor, lung carcinoma, et al) and can regulate tumor cell proliferation, anti-apoptosis, invasion and metastasis by different mechanisms leading to occurrence and development of tumors. In this review, we summarized current studies of the functions and mechanisms of BLACAT1 in malignant tumors. Key words: RNA, long noncoding; Bladder cancer associated transcript 1; Neoplasms; Therapeutic target; Review
{"title":"The functions and mechanisms of BLACAT1 in malignant tumors","authors":"Shuwa Xu, Hao-Ming Xia, Zewei Gao, R. Huang, Enyu Tang, Xing-ming Jiang","doi":"10.3760/CMA.J.CN431274-20190401-00375","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190401-00375","url":null,"abstract":"Long non-coding RNAs (lncRNAs) are a kind of transcripts which are longer than 200nt and have not protein-coding ability due to the lack of an open reading frame. However, lncRNAs can be involved in tumorigenesis and progression in various ways at the transcriptional and post-transcriptional levels. Bladder cancer associated transcript 1 (BLACAT1) as a lncRNA located on human chromosome 1q32.1, is ectopic expression in various tumors (bladder cancer, gastric malignant tumor, lung carcinoma, et al) and can regulate tumor cell proliferation, anti-apoptosis, invasion and metastasis by different mechanisms leading to occurrence and development of tumors. In this review, we summarized current studies of the functions and mechanisms of BLACAT1 in malignant tumors. \u0000 \u0000Key words: \u0000RNA, long noncoding; Bladder cancer associated transcript 1; Neoplasms; Therapeutic target; Review","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89410755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20190104-00025
Haiqing Liu, Hanchen Zhang, Ziliang Cheng, W. Zeng, C. Gong, Yue Hu, Zhuo Wu
Objective This study compares the magnetic resonance imaging (MRI) appearance of two types of breast tissue markers to investigate the appropriate clinical application of the markers. Methods Breast MRI of 69 patients (78 masses) with breast tissue markers had been placed were analyzed retrospectively from November 2015 to August 2018 in our hospital. The sizes and shapes of breast tissue markers were assessed in axial fat-suppressed T2-weighted images, T1-weighted images and contrast-enhanced T1-weighed images. Results The length of the coil nickel-free stainless steel markers were greater than ribbon titanium markers, with statistical difference in fat-suppressed T2-weighted images (P=0.039). In contrast-enhanced T1-weighted images, all coil nickel-free stainless steel markers showed >6 mm diameter and round shape, and ribbon titanium markers showed >6 mm diameter (n=20) or ≤6 mm diameter (n=8), and round (n=20), dot (n=7) or band (n=1) shapes. The categories of sizes and shapes in two types of breast tissue markers both had statistical significance (P<0.001, P<0.001). Conclusions Small breast lesions with breast tissue markers are not suitable for MRI evaluation. The artifact of ribbon titanium markers is smaller than coil nickel-free stainless steel markers, so they have less impact for lesions. The choice of the breast tissue markers and image evaluation methods should depend on the different clinical conditions. Key words: Magnetic resonance imaging; Breast neoplasms; Fiducial markers; Titanium; Stainless steel
{"title":"Effect of breast tissue marker on MRI evaluation for breast lesions and clinical significance","authors":"Haiqing Liu, Hanchen Zhang, Ziliang Cheng, W. Zeng, C. Gong, Yue Hu, Zhuo Wu","doi":"10.3760/CMA.J.CN431274-20190104-00025","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190104-00025","url":null,"abstract":"Objective \u0000This study compares the magnetic resonance imaging (MRI) appearance of two types of breast tissue markers to investigate the appropriate clinical application of the markers. \u0000 \u0000 \u0000Methods \u0000Breast MRI of 69 patients (78 masses) with breast tissue markers had been placed were analyzed retrospectively from November 2015 to August 2018 in our hospital. The sizes and shapes of breast tissue markers were assessed in axial fat-suppressed T2-weighted images, T1-weighted images and contrast-enhanced T1-weighed images. \u0000 \u0000 \u0000Results \u0000The length of the coil nickel-free stainless steel markers were greater than ribbon titanium markers, with statistical difference in fat-suppressed T2-weighted images (P=0.039). In contrast-enhanced T1-weighted images, all coil nickel-free stainless steel markers showed >6 mm diameter and round shape, and ribbon titanium markers showed >6 mm diameter (n=20) or ≤6 mm diameter (n=8), and round (n=20), dot (n=7) or band (n=1) shapes. The categories of sizes and shapes in two types of breast tissue markers both had statistical significance (P<0.001, P<0.001). \u0000 \u0000 \u0000Conclusions \u0000Small breast lesions with breast tissue markers are not suitable for MRI evaluation. The artifact of ribbon titanium markers is smaller than coil nickel-free stainless steel markers, so they have less impact for lesions. The choice of the breast tissue markers and image evaluation methods should depend on the different clinical conditions. \u0000 \u0000 \u0000Key words: \u0000Magnetic resonance imaging; Breast neoplasms; Fiducial markers; Titanium; Stainless steel","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88580033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
At present, the prevention and control of the COVID-19 is still severe, its pathogen SARS-CoV-2 is highly infectious and pathogenic, and the population is generally susceptible. Thus, it requires a higher standard to diagnose and treat patients with acute abdomen. The first step is to carry out procedures to identify whether the patient is infected or not. Those who are not infected can go through the normal treating procedures. For patients diagnosed with COVID-19 or suspected patients, the second step is to achieve classified diagnoses and treatments, and to adopt a treating plan that integrates TCM and western medicine. In order to protect patients and medical staff, the COVID-19 in hospital transmission must be avoided. For patients with COVID-19 who need emergency surgery, we must strictly comply with the hospital's protection regulations, closely coordinate the relevant departments of surgery, perform the three-level protection, operate in accordance with the principle of damage control in the negative pressure surgery room, and return to the isolation ward according to the prevention and control process after operation. For units without surgical conditions, patients should be transferred to hospital in time on the premise of maximum damage control, and patients must not be delayed for timely diagnosis and treatment due to the epidemic. Key words: Novel coronavirus; Pneumonia, viral; Acute abdominal diseases; Traditional Chinese and Western Medicine
{"title":"An integrated strategy of TCM and western medicine to prevent and treat acute abdomen during the outbreak of COVID-19","authors":"Guolei Li, Guoliang Tan, Yuan-hua Liu, Zhao Xu, H. Feng, Yali Zhang, Wei-Hong Xing, Zhi-feng Xu","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.002","url":null,"abstract":"At present, the prevention and control of the COVID-19 is still severe, its pathogen SARS-CoV-2 is highly infectious and pathogenic, and the population is generally susceptible. Thus, it requires a higher standard to diagnose and treat patients with acute abdomen. The first step is to carry out procedures to identify whether the patient is infected or not. Those who are not infected can go through the normal treating procedures. For patients diagnosed with COVID-19 or suspected patients, the second step is to achieve classified diagnoses and treatments, and to adopt a treating plan that integrates TCM and western medicine. In order to protect patients and medical staff, the COVID-19 in hospital transmission must be avoided. For patients with COVID-19 who need emergency surgery, we must strictly comply with the hospital's protection regulations, closely coordinate the relevant departments of surgery, perform the three-level protection, operate in accordance with the principle of damage control in the negative pressure surgery room, and return to the isolation ward according to the prevention and control process after operation. For units without surgical conditions, patients should be transferred to hospital in time on the premise of maximum damage control, and patients must not be delayed for timely diagnosis and treatment due to the epidemic. Key words: Novel coronavirus; Pneumonia, viral; Acute abdominal diseases; Traditional Chinese and Western Medicine","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82453873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.013
Wei Huang, H. Miao, Lin-hui Peng
Objective To investigate the relationship between long non-coding ovarian adenocarcinoma amplified RNA (LncRNA-OVAAL) and tumor recurrence and prognosis in uterine papillary serous carcinoma (UPSC). Methods From May 2012 to November 2016, 32 patients with UPSC in our hospital were selected as observation group, and 30 patients with other benign diseases were selected as control group. Real-time polymerase chain reaction (PCR) was used to detect the expression of LncRNA-OVAAL in the enrolled patients. The receiver operating characteristic (ROC) curve was used to analyze the cutoff value of LncRNA-OVAAL. The relationship between LncRNA-OVAAL expression and clinicopathological features was analyzed. The cumulative survival rate was calculated and survival analysis was performed. The Cox risk regression model was used to analyze the single-factor and multi-factor analysis of prognosis and overall survival rate. Results The expression of LncRNA-OVAAL in patients with UPSC was elevated, which was related to age, vascular invasion, menopause, recurrence and preoperative serum human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) (P<0.05). High expression of LncRNA-OVAAL was a risk factor for postoperative recurrence and overall survival in patients with UPSC (P<0.05). Conclusions The high expression of LncRNA-OVAAL has a certain evaluation value for predicting postoperative recurrence and prognosis in patients with UPSC. Key words: RNA, long noncoding; Uterine papillary serous carcinoma; Neoplasm recurrence; Prognosis
{"title":"The correlation between the expression of LncRNA-OVAAL and the recurrence and prognosis of uterine papillary serous carcinoma after operation","authors":"Wei Huang, H. Miao, Lin-hui Peng","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.013","url":null,"abstract":"Objective \u0000To investigate the relationship between long non-coding ovarian adenocarcinoma amplified RNA (LncRNA-OVAAL) and tumor recurrence and prognosis in uterine papillary serous carcinoma (UPSC). \u0000 \u0000 \u0000Methods \u0000From May 2012 to November 2016, 32 patients with UPSC in our hospital were selected as observation group, and 30 patients with other benign diseases were selected as control group. Real-time polymerase chain reaction (PCR) was used to detect the expression of LncRNA-OVAAL in the enrolled patients. The receiver operating characteristic (ROC) curve was used to analyze the cutoff value of LncRNA-OVAAL. The relationship between LncRNA-OVAAL expression and clinicopathological features was analyzed. The cumulative survival rate was calculated and survival analysis was performed. The Cox risk regression model was used to analyze the single-factor and multi-factor analysis of prognosis and overall survival rate. \u0000 \u0000 \u0000Results \u0000The expression of LncRNA-OVAAL in patients with UPSC was elevated, which was related to age, vascular invasion, menopause, recurrence and preoperative serum human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) (P<0.05). High expression of LncRNA-OVAAL was a risk factor for postoperative recurrence and overall survival in patients with UPSC (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The high expression of LncRNA-OVAAL has a certain evaluation value for predicting postoperative recurrence and prognosis in patients with UPSC. \u0000 \u0000 \u0000Key words: \u0000RNA, long noncoding; Uterine papillary serous carcinoma; Neoplasm recurrence; Prognosis","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86713902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.043
Miao Zhou, Ping Zhang, G. Ouyang
Umbilical cord blood is an alternative hematopoietic stem cell source has been widely recognized. Initially, umbilical cord blood transplantation was limited, given the low engraftment. So the method of improving cord blood homing and engraftment has been widely studied in various fields. This paper briefly reviews the progress of main researches in recent years. Key words: Cord blood stem cell transplantation; Homing; Engraftment; Review
{"title":"Research progresses of the way to improve umbilical cord blood stem cells homing and engraftment","authors":"Miao Zhou, Ping Zhang, G. Ouyang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.043","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.043","url":null,"abstract":"Umbilical cord blood is an alternative hematopoietic stem cell source has been widely recognized. Initially, umbilical cord blood transplantation was limited, given the low engraftment. So the method of improving cord blood homing and engraftment has been widely studied in various fields. This paper briefly reviews the progress of main researches in recent years. \u0000 \u0000Key words: \u0000Cord blood stem cell transplantation; Homing; Engraftment; Review","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86636252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.023
Jiale Ma, Yan Wang, L. Xiang, Luqun Wang, Jie Fu, Pu Zhang, Xiao-Ling Li
Objective To analyze the clinical efficacy, safety and influencing factors of decitabine (DAC)-based regimens in patients with myelodysplastic syndrome-refractory anemia with excess blasts (MDS-RAEB). Methods We performed a retrospective analysis of 63 patients with MDS-RAEB treated with DAC, evaluated the clinical efficacy and adverse reactions, and analyzed the influencing factors affecting survival. Results Among 63 patients, 23 were RAEB-1 and 40 were RAEB-2. The median treatment was 4 (2-13) courses. The total effective rate of DAC for MDS-RAEB was 58.7%(37/63), and the complete response rate was 20.6%(13/63). Among 37 patients who were effective, 20 (54.1%) patients performed efficacy after 2 courses. The median course of treatment to achieve the best effect was 3.5 (3-4) courses. With a median follow-up of 14 (2-68) months, 63 patients had a overall survival rate (OS) of 84.2% and a 1-year progression-free survival rate (PFS) of 73%. In univariate analysis, the factors that prolonged OS were that the best effect after medication was stable disease (SD) (to achieve complete remission, partial remission, complete bone marrow remission, hematological improvement) (P=0.009) and no thrombocytopenia at first diagnosis (P=0.019), the factor that prolongs PFS is the best effect above SD (P=0.003). Multivariate analysis suggested that the factors affecting OS and PFS were the best curative effects above SD (P=0.015 vs P=0.008). The adverse effects of decitabine in the treatment of MDS-RAEB were mainly bone marrow suppression and pulmonary infection. Conclusions Decitabine is an effective and well-tolerated drug in the treatment of MDS-RAEB. Response to decitabine treatment is one of the independent factors affecting the prognosis. Key words: Anemia, refractory, with excess of blasts; Drug therapy, combination; Decitabine; Prognosis; Factor analysis, statistical
目的分析地西他滨(DAC)治疗骨髓增生异常综合征难治性贫血伴原细胞过多(MDS-RAEB)的临床疗效、安全性及影响因素。方法回顾性分析63例经DAC治疗的MDS-RAEB患者的临床疗效及不良反应，分析影响患者生存的因素。结果63例患者中RAEB-1阳性23例，RAEB-2阳性40例。中位疗程为4(2-13)个疗程。DAC治疗MDS-RAEB的总有效率为58.7%(37/63)，完全缓解率为20.6%(13/63)。37例有效患者中，20例(54.1%)在2个疗程后有效。达到最佳效果的中位疗程为3.5(3-4)个疗程。中位随访14(2-68)个月，63例患者总生存率(OS)为84.2%，1年无进展生存率(PFS)为73%。单因素分析中延长OS的因素为用药后病情稳定(SD)(达到完全缓解、部分缓解、骨髓完全缓解、血液学改善)(P=0.009)和初诊无血小板减少(P=0.019)，延长PFS的因素为SD以上效果最佳(P=0.003)。多因素分析显示，影响OS和PFS的因素在SD以上疗效最佳(P=0.015 vs P=0.008)。地西他滨治疗MDS-RAEB的不良反应主要为骨髓抑制和肺部感染。结论地西他滨是治疗MDS-RAEB有效且耐受性良好的药物。地西他滨治疗反应是影响预后的独立因素之一。关键词:贫血，难治性，原细胞过多;药物治疗、联合用药;Decitabine;预后;因子分析、统计学
{"title":"Analysis on clinical efficacy and influencing factors of decitabine-based regimens in patients with myelodysplastic syndrome-refractory anemia with excess blasts","authors":"Jiale Ma, Yan Wang, L. Xiang, Luqun Wang, Jie Fu, Pu Zhang, Xiao-Ling Li","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.023","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.023","url":null,"abstract":"Objective \u0000To analyze the clinical efficacy, safety and influencing factors of decitabine (DAC)-based regimens in patients with myelodysplastic syndrome-refractory anemia with excess blasts (MDS-RAEB). \u0000 \u0000 \u0000Methods \u0000We performed a retrospective analysis of 63 patients with MDS-RAEB treated with DAC, evaluated the clinical efficacy and adverse reactions, and analyzed the influencing factors affecting survival. \u0000 \u0000 \u0000Results \u0000Among 63 patients, 23 were RAEB-1 and 40 were RAEB-2. The median treatment was 4 (2-13) courses. The total effective rate of DAC for MDS-RAEB was 58.7%(37/63), and the complete response rate was 20.6%(13/63). Among 37 patients who were effective, 20 (54.1%) patients performed efficacy after 2 courses. The median course of treatment to achieve the best effect was 3.5 (3-4) courses. With a median follow-up of 14 (2-68) months, 63 patients had a overall survival rate (OS) of 84.2% and a 1-year progression-free survival rate (PFS) of 73%. In univariate analysis, the factors that prolonged OS were that the best effect after medication was stable disease (SD) (to achieve complete remission, partial remission, complete bone marrow remission, hematological improvement) (P=0.009) and no thrombocytopenia at first diagnosis (P=0.019), the factor that prolongs PFS is the best effect above SD (P=0.003). Multivariate analysis suggested that the factors affecting OS and PFS were the best curative effects above SD (P=0.015 vs P=0.008). The adverse effects of decitabine in the treatment of MDS-RAEB were mainly bone marrow suppression and pulmonary infection. \u0000 \u0000 \u0000Conclusions \u0000Decitabine is an effective and well-tolerated drug in the treatment of MDS-RAEB. Response to decitabine treatment is one of the independent factors affecting the prognosis. \u0000 \u0000 \u0000Key words: \u0000Anemia, refractory, with excess of blasts; Drug therapy, combination; Decitabine; Prognosis; Factor analysis, statistical","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86358267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.02.003
Jing Cai, Zehua Wang
In the past two decades, laparoscopic surgery has been increasingly used in the treatment of early-stage cervical cancer because of equal survival and faster recovery compared to abdominal surgery. Recently, a phase III randomized controlled clinical trial revealed unexpected results that minimally invasive surgery was associated with significantly increased risks for tumor recurrence and death in patients with early-stage cervical cancer, causing a great debate worldwide. Herein, we highlighted the key points in the debate and tossed out several ideas on how to face and deal with the controversy. Key words: Uterine cervical neoplasms; Early-stage tumor; Laparoscopy
{"title":"Comments on the debate about laparoscopic surgery for early-stage cervical cancer","authors":"Jing Cai, Zehua Wang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.02.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.02.003","url":null,"abstract":"In the past two decades, laparoscopic surgery has been increasingly used in the treatment of early-stage cervical cancer because of equal survival and faster recovery compared to abdominal surgery. Recently, a phase III randomized controlled clinical trial revealed unexpected results that minimally invasive surgery was associated with significantly increased risks for tumor recurrence and death in patients with early-stage cervical cancer, causing a great debate worldwide. Herein, we highlighted the key points in the debate and tossed out several ideas on how to face and deal with the controversy. \u0000 \u0000Key words: \u0000Uterine cervical neoplasms; Early-stage tumor; Laparoscopy","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73636241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：