中国医师杂志最新文献

{"title":"Relationship between hemodynamics with hepatic reserve function in cirrhotic patients with portal hypertension","authors":"M. Jiang","doi":"10.3760/CMA.J.CN431274-20190104-00032","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190104-00032","url":null,"abstract":"Objective \u0000To investigate the relationship between hemodynamics with hepatic reserve function in cirrhosis patients complicated with portal hypertension (PHT), and to explore the significances of the two in evaluating the disease. \u0000 \u0000 \u0000Methods \u0000According to the Child score, 80 cirrhosis patients complicated with PHT from January 2016 to January 2018 in our hospital were divided into three grades: A, B and C, 35 healthy persons in the same period were selected as normal control group. The parameters of liver hemodynamics were detected by color Doppler ultrasound, and the items of liver reserve function were detected by automatic biochemical analyzer. The correlation between hemodynamic indexes and liver reserve function was analyzed by Pearson method, and the risk factors of liver cirrhosis with PHT were analyzed by logistic multiple regression. \u0000 \u0000 \u0000Results \u0000The diameter of portal inner vein (DPV), maximum speed of blood flow in the portal vein (PVX), mean speed of blood flow in the portal vein (PVM), quantity of blood flow in the main portal vein (QPV), albumin (ALB), cerealthirdtransaminase (ALT), aspartate transaminase (AST) and prothrombin time (PT) in the observation group were significantly higher than those in the control group (P<0.05), while the total bilirubin (TBIL) was significantly lower than that in the control group (P<0.05). The levels of DPV, PVX, PVM and QPV in patients with grade C were significantly higher than those in grade A and grade B (P<0.05); the levels of DPV, PVX, PVM and QPV in patients with grade B of liver function were significantly higher than those in grade A (P<0.05). The level of TBIL in patients with grade C liver function was significantly lower than that in grade A and grade B patients (P<0.05); ALB, ALT, AST and PT were significantly higher than those of grade A and grade B (P<0.05); the level of TBIL in patients with grade B of liver function was significantly lower than that of grade A (P<0.05), while the ALB, ALT, AST and PT were significantly higher than those in group A (P<0.05). DPV, PVM and QPV were significantly positively correlated with PT in cirrhosis patients with and PHT (P<0.05), PVM and QPV were significantly negatively correlated with TBIL (P<0.05). Regression analysis showed that hemodynamic indexes in DPV, PVX, PVM, QPV and liver reserve function indexes TBIL, ALB, ALT, AST, PT were risk factors for portal hypertension in cirrhosis. \u0000 \u0000 \u0000Conclusions \u0000Hemodynamics and hepatic reserve function indicators have certain regularity in different degrees of cirrhosis complicated with PHT patients, they are closely related and can be used as an important index in the evaluation and monitoring of cirrhosis with PHT. \u0000 \u0000 \u0000Key words: \u0000Liver cirrhosis; Portal hypertension; Hemodynamics; Hepatic reserve functional","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87779066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk of endobronchial biopsy-induced bleeding in different locations of lung cancer","authors":"Saibin Wang, Qian Ye","doi":"10.3760/CMA.J.CN431274-20190402-00381","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190402-00381","url":null,"abstract":"Objective \u0000To investigate risk of endobronchial biopsy (EBB)-induced bleeding in different locations of lung cancer. \u0000 \u0000 \u0000Methods \u0000The clinical data of 643 patients diagnosed with lung cancer were collected from January 2014 to February 2018. The association of lesions of location with the risk of EBB-induced bleeding was evaluated using multivariate regression analysis adjusted for demographics, tumor characteristics, and comorbidities. \u0000 \u0000 \u0000Results \u0000After adjusting for sex, age, smoking history, pathological type and stage of tumor, complications [chronic obstructive pulmonary disease (COPD), hypertension, diabetes and coronary heart disease], platelet count, prothrombin time and activated partial thromboplastin time, multivariate regression analysis showed that compared to incidence of EBB-induced bleeding in right lower bronchus, the odds ratio (95% confidence interval) of left main bronchus, left upper bronchus, left lower bronchus, right main bronchus, right upper bronchus, right middle bronchus, right middle lobar bronchus and the trachea were 5.24(2.23, 12.31), 2.08(1.14, 3.80), 1.93(1.01, 3.67), 2.92(1.14, 7.47), 1.81(1.00, 3.30), 4.91(1.94, 12.45), 1.33(0.48, 3.63) and 2.19(0.58, 8.30). \u0000 \u0000 \u0000Conclusions \u0000Patients with lung cancer located in the central airways were more likely to bleed upon EBB when compared lesions located in the peripheral bronchi. Lesions located in left main bronchus, left upper bronchus were the most likely to bleed upon EBB among the central airways and peripheral bronchi, respectively. \u0000 \u0000 \u0000Key words: \u0000Lung neoplasms; Bronchoscopy; Biopsy; Hemorrhage","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77512738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative real-time imaging-guided laparoscopic liver resection","authors":"Peng Lu, Hongguang Wang","doi":"10.3760/CMA.J.CN431274-20200306-00242","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20200306-00242","url":null,"abstract":"In recent years, laparoscopic hepatectomy has developed rapidly, but new challenges are posed to surgeons because of this surgical approach. The disadvantages of laparoscopic surgery can be effectively solved by using intraoperative real-time imaging guidance technology. Laparoscopic ultrasound can be used to discover and diagnose the nature of lesions, mark the important pipeline structure, determine the cutting edge, and guide puncture. ICG fluorescence imaging can be applied to the identification, localization, characterization of intraoperative lesions, the marking of specific liver segments and the prevention of postoperative bile leakage. These two technologies are the only two real-time imaging guidance technologies in laparoscopic hepatectomy at present, which truly make up for the shortcomings of laparoscopic liver surgery such as the inability to palpate and limited exploration exposure. \u0000 \u0000Key words: \u0000Laparoscopy; Hepatectomy; Surgery, image-guided","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75683248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationships between different doses of vancomycin with blood drug trough concentration and renal dysfunction in children with severe infection in ICU","authors":"Desheng Zhu","doi":"10.3760/CMA.J.CN431274-20181220-02385","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20181220-02385","url":null,"abstract":"Objective \u0000To investigate the relationships between different doses of vancomycin with blood drug trough concentration and renal dysfunction in children with severe infection in intensive care unit (ICU). \u0000 \u0000 \u0000Methods \u0000100 children with severe infection treated with vancomycin from January 2018 to November 2018 in the Ⅱ Department of Critical Care Medicine of Hunan Children's Hospital were studied, according to the dosage, they were divided into high-dose group [15 mg/(kg·time), 57 cases] and low-dose group [15 mg/(kg·time), 43 cases]. At the same time, according to the condition of renal dysfunction, children were divided into normal renal function group (42 cases), mild injury group (43 cases), moderate injury group (15 cases). The blood drug trough concentration was measured, and its relationship with serum creatinine (Scr), serum urea nitrogen (BUN), and renal dysfunction was analyzed. At the same time, the therapeutic effects of different doses of vancomycin were evaluated. \u0000 \u0000 \u0000Results \u0000The cure rate and blood drug trough concentration of children with severe infection in high-dose group were significantly higher than those in low-dose group (P<0.05), and the time to reach effective blood drug trough concentration was significantly shorter than that in low-dose group (P<0.05); the levels of serum Scr and BUN in low-dose group and high-dose group were significantly lower than those before treatment (P< 0.05); the blood drug trough concentration and the proportion of reaching the target trough concentration in mild injury group were significantly higher than those in normal group and moderate injury group (P<0.05); the dose of vancomycin in mild injury group and moderate injury group was significantly higher than that in normal group (P<0.05), and the course of treatment in mild injury group and moderate injury group was lower than that in normal group (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The high dose of vancomycin 15 mg/(kg/time) is effective in the treatment of ICU children with severe infection. the blood drug trough concentration and renal dysfunction should be monitored and individualized treatment plan should be formulated. \u0000 \u0000 \u0000Key words: \u0000Vancomycin; Drug dosage; Plasma concentration; Renal dysfunction; Infection; Child","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78544788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of sivelestat sodium on early inflammatory reaction and pulmonary edema in rats with smoke inhalation induced lung injury","authors":"Xuelan Liu, Mingxia Wang","doi":"10.3760/CMA.J.CN431274-20190124-00071","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190124-00071","url":null,"abstract":"Objective \u0000To investigate the effects of sivelestat sodium on early inflammatory response and pulmonary edema in rats with smoke inhalation-induced lung injury. \u0000 \u0000 \u0000Methods \u0000Seventy-five Sprague-Dawley rats were randomly divided into control group, model group, low-dose group, middle-dose group and high-dose group. The smoke inhalation model was continued except for the control group. The rats were given intraperitoneal injection of normal saline, cevicell sodium 10 mg/kg, 20 mg/kg and 30 mg/kg. The general condition and lung tissue were observed after 24 hours. \u0000 \u0000 \u0000Results \u0000Compared with the control group, rats in each group had a certain degree of lung injury, alveolar wall thickening, alveolar interstitial hyperemia, etc. The alveolar septal thickness, lung tissue wet-dry (W/D) level, the incidence of edema and the levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), neutrophil elastase (NE) and myeloperoxidase (MPO) in the model group were significantly higher than those of the other 4 groups. The lung function recovery was highest in the low dose group and the alveolar septal thickness was the highest among the dose group. The alveolar wall thickening incidence of W/D level and pulmonary edema in lung tissue in the low dose group were (6.76±0.40)μm, (5.18±0.13) and 40.00%, respectively, and the levels of TNF-α, IL-6, NE and MPO were (19.62±0.83)pg/L, (9.41±0.25)pg/L, (6.23±0.18)μg/L and (30.64±0.87)pg/L, significantly better than the middle dose group and high dose group (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Sivelestat sodium can significantly affect the smoke inhalation lung injury, and improve the recovery of liver function, which can significantly reduce the incidence of inflammation and pulmonary ede-ma in the lung, but its therapeutic effect and drug delivery. There was a significant association between doses and therapeutic effect, in the case of rats, a dose of 10 mg/kg was the best for treatment. \u0000 \u0000 \u0000Key words: \u0000Lung injury; Smoke inhalation injury; Sivelestat sodium; Inflammation; Pulmonary edema; Rats","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72664404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The expressions of miR-26a and TLR in peripheral blood mononuclear cells of patients with psoriasis vulgaris and their relationships with disease activity","authors":"Yingjuan Wang, W. Cao","doi":"10.3760/CMA.J.CN431274-20190322-00320","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190322-00320","url":null,"abstract":"Objective \u0000To investigate the expressions of micro RNA-26a (miR-26a) and toll-like receptor (TLR) in peripheral blood mononuclear cells (PBMCs) of patients with psoriasis vulgaris (PV), and to analyze their relationships with disease activity. \u0000 \u0000 \u0000Methods \u0000Total 200 PV patients treated in our hospital from June 2016 to June 2018 were selected as the study group. According to Psoriasis Area and Severity Index (PASI) score, the PV patients were divided into 71 cases in mild group, 84 cases in moderate group, 45 cases in severe group, at the same time, 100 healthy people in the physical examination center were selected as the control group. The mRNA levels of TLR2 and TLR4 in PBMCs were detected by fluorescence quantitative polymerase chain reaction (PCR); serum C-reactive protein (CRP) level was detected by immunoturbidimetry; Pearson correlation was used to analyze the relationships between the expressions of miR-26a, TLR2 and TLR4 with the activity of PV (PASI score and CRP level). \u0000 \u0000 \u0000Results \u0000There was no significant difference in sex, age, body mass index (BMI) and course of disease among PV patients of different grades in the study group (P>0.05); the mRNA expression levels of miR-26a, TLR2 and TLR4 in PBMCs of the study group were significantly higher than those of the control group (P<0.05); the PASI score, serum CRP level, miR-26a, TLR2 and TLR4 mRNA expression levels in severe PV group were significantly higher than those in mild group and moderate group (P<0.05), and the above indexe in the moderate group were significantly higher than those in mild group (P<0.05); the PASI score and serum CRP level of PV patients were positively correlated with miR-26a, TLR2 and TLR4 mRNA expression levels (P<0.01). \u0000 \u0000 \u0000Conclusions \u0000The mRNA expression levels of miR-26a, TLR2 and TLR4 in PBMCs of PV patients are increased and positively correlated with PASI score and CRP level, which can reflect the activity of PV disease. \u0000 \u0000 \u0000Key words: \u0000Psoriasis; Peripheral blood mononuclear cells; miR-26a; Toll-like receptors","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80639324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical research of fractional excretion of IgG on predicting drug responsiveness in patients with idiopathic membranous nephropathy","authors":"Xiaoyang Yu, Chao Liu, Jie Feng, Liyi Xie","doi":"10.3760/CMA.J.CN431274-20190307-00214","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190307-00214","url":null,"abstract":"Objective \u0000To explore the predictive value of fractional excretion of IgG (FE IgG) on drug responsiveness and remission in patients with idiopathic membranous nephropathy (IMN). \u0000 \u0000 \u0000Methods \u0000Retrospective analysis of 82 patients with IMN diagnosed by clinical and pathological data and regularly followed up from April 2014 to August 2017. Receiver operating characteristic (ROC) curve was used to determine the FE IgG threshold. Comparing the difference of remission time under different baseline levels of FE IgG, and analyzing the effect of different levels of FE IgG on the drug responsiveness of immunosuppressive therapy (tacrolimus or cyclophosphamide) and supportive therapy. \u0000 \u0000 \u0000Results \u0000Areas under the curve (AUC) of estimated glomerular filtration rate (eGFR), 24-hour urinary protein quantity and FE IgG were 0.509, 0.701 and 0.948, respectively. Before treatment, there was no significant difference in gender, age, mean arterial pressure and eGFR between the high FE IgG group (FE IgG>0.029) and low FE IgG group (FE IgG 0.05). The remission time of high FE IgG group was (18.75±6.81)months, while it was (8.46±3.74)months in low FE IgG group, with significant difference (P<0.01). There was no difference in remission time of immunosuppressive therapy and supportive therapy in low FE IgG group (P=0.265), bo-th of which were lower than the high-level immunosuppressive therapy group (P<0.001). The remission time of tacrolimus was shorter than that of cyclophosphamide in high FE IgG group, but with no significant difference (P=0.131). There was significant difference in the remission time of tacrolimus between the high and low level groups of FE IgG (P<0.01). Under electron microscope, the ratio of foot process fusion and podocyte diffuse vacuolar degeneration in the high level group of FE IgG was higher than that in the low level group (P<0.01). \u0000 \u0000 \u0000Conclusions \u0000FE IgG can be used as a clinical indicator for predicting drug responsiveness and remission in patients with IMN, and is essential for early identification of high-risk patients and for making clinical decisions. Patients with high FE-IgG may benefit from early initiation of immunosuppressive therapy. \u0000 \u0000 \u0000Key words: \u0000Immunoglobulin G; Renal elimination; Remission time; Urinary protein; Idiopathic membranous nephropathy","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78709088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A survey of comorbidity and health behaviors of diabetic patients in an area of Beijing","authors":"Y. Xing, Pei Wang, Xinghua Yang","doi":"10.3760/CMA.J.CN431274-20191215-01428","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20191215-01428","url":null,"abstract":"Objective \u0000By investigating the prevalence of comorbidity and health behaviors among diabetes patients in Beijing, to provide reference for effective health management of diabetic patients. \u0000 \u0000 \u0000Methods \u0000Based on a cross-sectional survey of 10 334 diabetic patients managed by a community health information center in Beijing from 2012 to 2014, the data of 10 334 diabetic patients were analyzed systematically. The common diseases investigated included cardiovascular and cerebrovascular diseases, orthopedic diseases, chronic respiratory/pulmonary diseases, tumors, chronic kidney diseases and other chronic diseases disease. At the same time, the health behaviors of diabetic patients were investigated, including diet behavior, exercise, work intensity, traffic mode, smoking and sleeping. \u0000 \u0000 \u0000Results \u0000⑴ There were 521 patients with simple diabetes and 9 813 patients with comorbidity. The prevalence of comorbidity was 94.96%. ⑵ There were 6 279 patients with one kind of comorbidity, accounting for 63.99%; 2 726 patients with two kinds of comorbidity, accounting for 27.78%; 808 patients with two or more kinds of comorbidity, accounting for 8.23%; among them, there were 6 153 patients with cardiovascular and cerebrovascular comorbidi-ty, accounting for 62.70%. ⑶ There were significant differences in diet taste preference, whether they often eat unhealthy food, whether the dietary structure is reasonable, intake of tofu and bean products, average daily vegetable, average daily fruit, average daily egg, average daily fish and meat, reduced food intake, regular exercise, exercise mode, duration of each exercise, comprehensive classification of physical activity, other physical exercise, comprehensive score of exercise, working hours per week, walking time to work or shopping, cycling time to work or shopping, transportation for going to work or shopping, walking out in good weather, smoking, sleep difficulties between simple diabetes and comorbidity patients (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The incidence of diabetic comorbidity is high, among which cardiovascular and cerebrovascular diseases are the most common. There are some differences in diet behavior, exercise, work, transportation and sleep between simple diabetes and comorbidity patients, which may be the cause of comorbidity. \u0000 \u0000 \u0000Key words: \u0000Diabetes mellitus; Comorbidity; Prevalence; Health behavior","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87734146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application value of DSC-PWI in ischemic cerebrovascular disease","authors":"Yanping Jing, B. Luo, Zhengrong Gao, Xinfeng Xu, Li Yao, T. Cheng, Yan Zhang, Jingliang Cheng","doi":"10.3760/CMA.J.CN431274-20181219-02378","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20181219-02378","url":null,"abstract":"Objective \u0000To explore the application value in cerebral blood perfusion status of dynamic susceptibility contrast enhanced perfusion weighted imaging (DSC-PWI) in ischemic cerebrovascular disease (ICVD). \u0000 \u0000 \u0000Methods \u0000Retrospective analysis of 31 cases ICVD head magnetic resonance imaging (MRI), diffusion weighted imaging (DWI), magnetic resonance angiography (MRA) and DSC-PWI image in clinical diagnosis, and selectively analyze parameters including relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), mean transit time (MTT) and time to peak (TTP) for generalize its characteristics. \u0000 \u0000 \u0000Results \u000031 cases of ICVD, 16 cases hypoperfusion, rCBF decreased significantly, rCBV decreased, MTT and TTP prolonged, include 7 cases of large vessel disease and 5 cases of small vessel disease. The collateral circulation formed 9 cases, including 3 cases with good compensation, rCBF normal, rCBV normal, MTT and TTP prolonged, 6 cases with bad compensation, rCBF decreased, rCBV normal or increased, MTT and TTP prolonged. The blood reperfusion in 3 cases, rCBF normal or slightly increased, rCBV increased, MTT shortened or normal, and TTP shortened. The excessive perfusion in 3 cases, rCBF significantly increased and rCBV significantly increased, with MTT and TTP shortened. \u0000 \u0000 \u0000Conclusions \u0000DSC-PWI can reliably reflect the perfusion state and collateral circulation compensation of ICVD, so as to guide the selection of clinical treatment program and significantly improve the prognosis of patients. \u0000 \u0000 \u0000Key words: \u0000Hypoxia-ischemia, brain; Magnetic resonance imaging; Dynamic susceptibility contrast enhanced perfusion weighted imaging","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78597800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of propensity score method to analyze the effect of Maixuekang capsule on the treatment outcome of coronary heart disease","authors":"Ren-bo Chen, Guo-zhong Gai, Wen-li Zhang, Yan Zhuang, Yanming Xie","doi":"10.3760/CMA.J.CN431274-20190213-00126","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190213-00126","url":null,"abstract":"Objective \u0000To analyze the effect of Maixuekang Capsule on the treatment outcome of coronary heart disease (CHD) by propensity score. \u0000 \u0000 \u0000Methods \u0000Based on the electronic medical record database of 22 large-scale tertiary hospitals nationwide, this study matched the coronary heart disease patients using and not using Maixuekang capsule according to a certain standard (1∶1). After matching, there were 2 464 cases in the patients group (group A) and the patients group (group B). In the database, the recombination of \" recovery\" and \" improvement\" is defined as effective treatment, and \" invalid\" , \" death\" and \" other\" are combined as ineffective treatment population. The effectiveness of the two groups after the re combination is compared by propensity score. \u0000 \u0000 \u0000Results \u0000The results of χ2 test showed that the difference between the two groups was statistically significant (P 0, and there was statistical significance (P<0.01). \u0000 \u0000 \u0000Conclusions \u0000The therapeutic effect of Maixuekang capsule on coronary heart disease is higher than that of patients without the drug. \u0000 \u0000 \u0000Key words: \u0000Propensity score; Maixuekang capsule; Coronary disease; Electronic health records","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84100573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}