Objective To analyze the curative effect of 56 cases with surgical operation of congenital tumor in conus medullaris position, to provide valuable reference information for the surgical operation of congenital tumor in conus medullaris position. Methods The cases were from 56 patients with congenital tumors in conus medullaris position in Xinjiang Uygur municipal people's hospital from January 2015 to February 2018. According to the classifications of congenital tumors in the conus medullaris position, surgical operation was performed on patients. The curative effect of patients with all kinds of congenital tumors in the conus medullaris position was analyzed and summarized. Results After 9 months of the follow-up: ⑴ There were totally 18 cases of epidermoid cysts, 16 cases with obvious improvement in lower limb numbness and lower limb motor function, 13 cases with the pain degree effectively relieved and 3 cases without significant improvement in early defecation function. ⑵ There were 15 cases of teratomas, 13 cases without significant improvement in lower extremity numbness, 2 cases with reduced lower extremity numbness, 3 cases with reduced urination and defecation function disturbance and 1 case not recovered. There was no recurrence of tumor. ⑶ There were 8 lipoma patients who were cured and discharged without urination and defecation function disturbance. Life was basically self-sustaining. ⑷ There were 9 cases of hemangioblastoma with significant improvement in spinal cord function, 5 cases without postoperative pain symptoms and 1 case with significant improvement in pain degree. ⑸ There were 6 cases of ependymoma, 2 cases with significant reduction on limb numbness symptoms, 1 case with urinary retention after surgery. There was no significant change in muscle strength of the 2 cases before and after surgery. Conclusions The clinical effect of surgical operation of congenital tumor in conus medullaris position is clear. Combined with imaging examination and attention to surgical precautions, the surgical treatment effect of congenital tumors in the conus region of the spinal cord can be effectively improved. Key words: Spinal cord neoplasms; Conus medullaris; Surgical procedures, operative
{"title":"Clinical analysis of 56 cases with surgical operation of congenital tumor in conus medullaris position","authors":"Yalikun Aikebaier, Xiaoyuan Huang, null Paerhatijiang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.016","url":null,"abstract":"Objective \u0000To analyze the curative effect of 56 cases with surgical operation of congenital tumor in conus medullaris position, to provide valuable reference information for the surgical operation of congenital tumor in conus medullaris position. \u0000 \u0000 \u0000Methods \u0000The cases were from 56 patients with congenital tumors in conus medullaris position in Xinjiang Uygur municipal people's hospital from January 2015 to February 2018. According to the classifications of congenital tumors in the conus medullaris position, surgical operation was performed on patients. The curative effect of patients with all kinds of congenital tumors in the conus medullaris position was analyzed and summarized. \u0000 \u0000 \u0000Results \u0000After 9 months of the follow-up: ⑴ There were totally 18 cases of epidermoid cysts, 16 cases with obvious improvement in lower limb numbness and lower limb motor function, 13 cases with the pain degree effectively relieved and 3 cases without significant improvement in early defecation function. ⑵ There were 15 cases of teratomas, 13 cases without significant improvement in lower extremity numbness, 2 cases with reduced lower extremity numbness, 3 cases with reduced urination and defecation function disturbance and 1 case not recovered. There was no recurrence of tumor. ⑶ There were 8 lipoma patients who were cured and discharged without urination and defecation function disturbance. Life was basically self-sustaining. ⑷ There were 9 cases of hemangioblastoma with significant improvement in spinal cord function, 5 cases without postoperative pain symptoms and 1 case with significant improvement in pain degree. ⑸ There were 6 cases of ependymoma, 2 cases with significant reduction on limb numbness symptoms, 1 case with urinary retention after surgery. There was no significant change in muscle strength of the 2 cases before and after surgery. \u0000 \u0000 \u0000Conclusions \u0000The clinical effect of surgical operation of congenital tumor in conus medullaris position is clear. Combined with imaging examination and attention to surgical precautions, the surgical treatment effect of congenital tumors in the conus region of the spinal cord can be effectively improved. \u0000 \u0000 \u0000Key words: \u0000Spinal cord neoplasms; Conus medullaris; Surgical procedures, operative","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89483505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.018
W. Yao
Objective To investigate the changes of serum carcinoembryonic antigen (CEA), lactate dehydrogenase (LDH), β2-microglobulin (β2-MG) levels in non-Hodgkin's lymphoma (NHL) patients and their clinical significance. Methods From February 2015 to February 2018, 54 patients with NHL who were hospitalized in Shiyan People's Hospital were selected as the observation group. All patients underwent two cycles of chemotherapy combined with radiation therapy. Another 54 healthy subjects were selected as the control group. To observe the changes of serum LDH, β2-MG, CEA levels in the control group, and compare the changes of serum LDH, β2-MG, CEA levels before and after treatment with different clinical stages, different conditions, and different effects in NHL. Results The levels of serum LDH, β2-MG, and CEA in the observation group were higher than those in the control group (P 0.05). While after treatment, the levels of serum LDH, β2-MG and CEA in complete relief (CR) and partial remission (PR) patients were lower than those before treatment (P<0.05), and were lower than those in SD and PD patients. Conclusions The level of serum LDH, β2-MG and CEA in patients with NHL increased, and the combined detection of the level changes is of great clinical value in the determination of clinical stage, malignant degree, clinical efficacy and prognosis of NHL patients. Key words: Lymphoma, non-hodgkin; Neoplasm staging; Carcinoembryonic antigen; Lactate dehydrogenase; beta 2-microglobulin
{"title":"Changes of serum LDH, CEA and β2-MG levels in non-Hodgkin's lymphoma patients in different situations and their clinical significance","authors":"W. Yao","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.018","url":null,"abstract":"Objective \u0000To investigate the changes of serum carcinoembryonic antigen (CEA), lactate dehydrogenase (LDH), β2-microglobulin (β2-MG) levels in non-Hodgkin's lymphoma (NHL) patients and their clinical significance. \u0000 \u0000 \u0000Methods \u0000From February 2015 to February 2018, 54 patients with NHL who were hospitalized in Shiyan People's Hospital were selected as the observation group. All patients underwent two cycles of chemotherapy combined with radiation therapy. Another 54 healthy subjects were selected as the control group. To observe the changes of serum LDH, β2-MG, CEA levels in the control group, and compare the changes of serum LDH, β2-MG, CEA levels before and after treatment with different clinical stages, different conditions, and different effects in NHL. \u0000 \u0000 \u0000Results \u0000The levels of serum LDH, β2-MG, and CEA in the observation group were higher than those in the control group (P 0.05). While after treatment, the levels of serum LDH, β2-MG and CEA in complete relief (CR) and partial remission (PR) patients were lower than those before treatment (P<0.05), and were lower than those in SD and PD patients. \u0000 \u0000 \u0000Conclusions \u0000The level of serum LDH, β2-MG and CEA in patients with NHL increased, and the combined detection of the level changes is of great clinical value in the determination of clinical stage, malignant degree, clinical efficacy and prognosis of NHL patients. \u0000 \u0000 \u0000Key words: \u0000Lymphoma, non-hodgkin; Neoplasm staging; Carcinoembryonic antigen; Lactate dehydrogenase; beta 2-microglobulin","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78485112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.020
H. Mo, Yuan-Qiao Huang, Gunshao Ma, Qin Xu, Li-Ping Wu, L. Fang
Objective To investigate the clinical effect of preoperative computed tomography (CT) measurement of acetabulum femoral neck combined anteversion in primary total hip arthroplasty (THA). Methods From March 2016 to may 2018, 48 patients (90 hips) with developmental dysplasia of the hip (DDH) who were treated with THA in the orthopaedic department of Jiangmen Central Hospital were measured by X-ray and spiral CT three-dimensional reconstruction technology before operation, and the best combined anteversion angle of acetabulum was determined before implementing THA, which was CT group; the remaining 42 patients were not measured by CT before operation, which was X-ray group. The difference of acetabulum cup anteversion angle, acetabulum femoral neck combined anteversion angle and preoperation angle were evaluated by three-dimensional computed tomography (3D-CT) in CT group. Results There was no significant difference in operative time, intraoperative blood loss, time of getting out of bed and length of lower limbs between the two groups (P>0.05). In CT group, the acetabulum cup anteversion and acetabulum femoral neck anteversion were close to the pre-operative angle at 2 and 3 months postoperatively (P>0.05). The Harris hip score of CT group was significantly higher than that of X-ray group at 2 and 3 months after operation, and the incidence of deep vein thrombosis was 6.25%, significantly lower than that of X-ray group (21.43%) (P 0.05). Conclusions For DDH patients who received THA for the first time, preoperative CT measurement of acetabulum femoral neck combined with anteversion is conducive to the formulation of the best combined anteversion adjustment scheme, which can obtain the maximum initial stability, improve the surgical effect and reduce the occurrence of dislocation of prosthesis. Key words: Tomography, X-ray computed; Acetabulum; Femur neck; Hip dysplasia; Arthroplasty, replacement, hip
{"title":"Clinical application of CT measurement in primary total hip arthroplasty of DDH patients","authors":"H. Mo, Yuan-Qiao Huang, Gunshao Ma, Qin Xu, Li-Ping Wu, L. Fang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.020","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.020","url":null,"abstract":"Objective \u0000To investigate the clinical effect of preoperative computed tomography (CT) measurement of acetabulum femoral neck combined anteversion in primary total hip arthroplasty (THA). \u0000 \u0000 \u0000Methods \u0000From March 2016 to may 2018, 48 patients (90 hips) with developmental dysplasia of the hip (DDH) who were treated with THA in the orthopaedic department of Jiangmen Central Hospital were measured by X-ray and spiral CT three-dimensional reconstruction technology before operation, and the best combined anteversion angle of acetabulum was determined before implementing THA, which was CT group; the remaining 42 patients were not measured by CT before operation, which was X-ray group. The difference of acetabulum cup anteversion angle, acetabulum femoral neck combined anteversion angle and preoperation angle were evaluated by three-dimensional computed tomography (3D-CT) in CT group. \u0000 \u0000 \u0000Results \u0000There was no significant difference in operative time, intraoperative blood loss, time of getting out of bed and length of lower limbs between the two groups (P>0.05). In CT group, the acetabulum cup anteversion and acetabulum femoral neck anteversion were close to the pre-operative angle at 2 and 3 months postoperatively (P>0.05). The Harris hip score of CT group was significantly higher than that of X-ray group at 2 and 3 months after operation, and the incidence of deep vein thrombosis was 6.25%, significantly lower than that of X-ray group (21.43%) (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000For DDH patients who received THA for the first time, preoperative CT measurement of acetabulum femoral neck combined with anteversion is conducive to the formulation of the best combined anteversion adjustment scheme, which can obtain the maximum initial stability, improve the surgical effect and reduce the occurrence of dislocation of prosthesis. \u0000 \u0000 \u0000Key words: \u0000Tomography, X-ray computed; Acetabulum; Femur neck; Hip dysplasia; Arthroplasty, replacement, hip","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84169191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.007
Zhenguo Han
Objective To research the effect of Qishenghuoxue granules in the treatment of sepsis combined with myocardial injury. Methods A total of 63 patients with sepsis combined with myocardial injury were randomly divided into two groups: 33 cases in control group (conventional therapy for 7 d) and 30 cases in observation group (Qishenhuoxue granule for 7 d). Thromboxane A2 (TXA2), prostaglandin I2 (PGI2), endothelin 1 (ET-1) and other cytokines were detected by enzyme-linked immunosorbent assay (ELISA). At the same time blood pressure, pulse, echocardiography were recorded. The mortality rate at the 28th day and the above values were statistically analyzed. Results On the 7th day after the intervention of Qishenhuoxue granule, N-terminal pro-brain natriuretic peptid (NT-proBNP) and troponin T (TNT) in the observation group and the control group were significantly lower than those on the 1st day, but there was no significant difference between the two groups at the same time point (P>0.05); On the 7th day after the intervention of Qishenhuoxue granule, the levels of angiotensin Ⅱ (Ang-Ⅱ) and ET-1 in the observation group were significantly lower than those in the control group (P<0.01), but there was no significant difference between the two groups in cardiac function index and 28 day mortality. Conclusions The Chinese herbal preparation Qishenhuoxue granule could reduce the blood levels of Ang-Ⅱ and ET-1, but its effect on improving myocardial injury is still worthy of further study. Key words: Sepsis; Cardiomyopathies; Qishenhuoxue granule; Cytokines
{"title":"Effects of Qishenhuoxue granule in sepsis combined with myocardial injury","authors":"Zhenguo Han","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.007","url":null,"abstract":"Objective \u0000To research the effect of Qishenghuoxue granules in the treatment of sepsis combined with myocardial injury. \u0000 \u0000 \u0000Methods \u0000A total of 63 patients with sepsis combined with myocardial injury were randomly divided into two groups: 33 cases in control group (conventional therapy for 7 d) and 30 cases in observation group (Qishenhuoxue granule for 7 d). Thromboxane A2 (TXA2), prostaglandin I2 (PGI2), endothelin 1 (ET-1) and other cytokines were detected by enzyme-linked immunosorbent assay (ELISA). At the same time blood pressure, pulse, echocardiography were recorded. The mortality rate at the 28th day and the above values were statistically analyzed. \u0000 \u0000 \u0000Results \u0000On the 7th day after the intervention of Qishenhuoxue granule, N-terminal pro-brain natriuretic peptid (NT-proBNP) and troponin T (TNT) in the observation group and the control group were significantly lower than those on the 1st day, but there was no significant difference between the two groups at the same time point (P>0.05); On the 7th day after the intervention of Qishenhuoxue granule, the levels of angiotensin Ⅱ (Ang-Ⅱ) and ET-1 in the observation group were significantly lower than those in the control group (P<0.01), but there was no significant difference between the two groups in cardiac function index and 28 day mortality. \u0000 \u0000 \u0000Conclusions \u0000The Chinese herbal preparation Qishenhuoxue granule could reduce the blood levels of Ang-Ⅱ and ET-1, but its effect on improving myocardial injury is still worthy of further study. \u0000 \u0000 \u0000Key words: \u0000Sepsis; Cardiomyopathies; Qishenhuoxue granule; Cytokines","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88232325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.046
Meijuan Ding
Thymidine kinase 1 (TK1) is associated with the occurrence of early malignant tumor, tumor metastasis, recurrence, and the changes of TK1 in the treatment can also reflect the sensitivity of tumor to treatment. Circulating tumor cells (CTC) are removed from the primary tumor or metastatic tumor to blood. The appearance of CTC in malignant tumors is usually related to the poor prognosis, such as metastasis and recurrence, short survival time and so on. The combination of TK1 and CTC can also be used as an independent predictor of survival. Now we analyse and summarize the role of TK1 and CTC in tumorigenesis and development . Key words: Thymidine kinase; Neoplastic cells, circulating; Neoplasms; Review
{"title":"Application of thymidine kinase 1 and circulating tumor cell in malignant solid tumor","authors":"Meijuan Ding","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.046","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.046","url":null,"abstract":"Thymidine kinase 1 (TK1) is associated with the occurrence of early malignant tumor, tumor metastasis, recurrence, and the changes of TK1 in the treatment can also reflect the sensitivity of tumor to treatment. Circulating tumor cells (CTC) are removed from the primary tumor or metastatic tumor to blood. The appearance of CTC in malignant tumors is usually related to the poor prognosis, such as metastasis and recurrence, short survival time and so on. The combination of TK1 and CTC can also be used as an independent predictor of survival. Now we analyse and summarize the role of TK1 and CTC in tumorigenesis and development . \u0000 \u0000 \u0000Key words: \u0000Thymidine kinase; Neoplastic cells, circulating; Neoplasms; Review","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87315499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.002
D. Tian, W. Qi, X. Lai, Yunchao Li
Objective To investigate the relationship between clinical parameters related to acute bacterial dysentery and other infectious diarrhea in adults. Methods From April to October 2018, 70 patients with clinical diagnosis of acute bacterial dysentery, 180 patients with clinical diagnosis of infectious diarrhea and 399 patients with diarrhea to be examined were investigated retrospectively. The collected data included gender, age, time from onset to treatment, maximum body temperature, main symptoms, epidemiological history, blood routine, C-reactive protein and stool routine. Analysis of these clinical factors related to acute bacterial dysentery and other infectious diarrhea. Results A total of 70 patients with acute bacterial dysentery, 180 patients with other infectious diarrhea and 399 patients with diarrhea of unknown origin were investigated. The positive rate of epidemiology in the three groups was statistically significant (P<0.05); the age of onset of bacterial dysentery was younger than that in patients with diarrhea of unknown origin (P<0.05). Compared with the other two groups of patients, the onset to visit time was earlier, the number of vomiting was higher, the incidence of fever and tenesmus was higher, and the levels of white blood cells, neutrophils and C-reactive protein were significantly increased (P<0.05). Conclusions Patients with acute bacterial dysentery, other infectious diarrhea, and diarrhea of unknown origin have some differences in epidemiological history, age at onset, clinical manifestations, and laboratory tests. Key words: Adult; Bacterial dysentery; Infectious diarrhea
{"title":"Analysis of relationship between clinical parameters related to acute bacterial dysentery and other infectious diarrhea in adults","authors":"D. Tian, W. Qi, X. Lai, Yunchao Li","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.002","url":null,"abstract":"Objective \u0000To investigate the relationship between clinical parameters related to acute bacterial dysentery and other infectious diarrhea in adults. \u0000 \u0000 \u0000Methods \u0000From April to October 2018, 70 patients with clinical diagnosis of acute bacterial dysentery, 180 patients with clinical diagnosis of infectious diarrhea and 399 patients with diarrhea to be examined were investigated retrospectively. The collected data included gender, age, time from onset to treatment, maximum body temperature, main symptoms, epidemiological history, blood routine, C-reactive protein and stool routine. Analysis of these clinical factors related to acute bacterial dysentery and other infectious diarrhea. \u0000 \u0000 \u0000Results \u0000A total of 70 patients with acute bacterial dysentery, 180 patients with other infectious diarrhea and 399 patients with diarrhea of unknown origin were investigated. The positive rate of epidemiology in the three groups was statistically significant (P<0.05); the age of onset of bacterial dysentery was younger than that in patients with diarrhea of unknown origin (P<0.05). Compared with the other two groups of patients, the onset to visit time was earlier, the number of vomiting was higher, the incidence of fever and tenesmus was higher, and the levels of white blood cells, neutrophils and C-reactive protein were significantly increased (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Patients with acute bacterial dysentery, other infectious diarrhea, and diarrhea of unknown origin have some differences in epidemiological history, age at onset, clinical manifestations, and laboratory tests. \u0000 \u0000 \u0000Key words: \u0000Adult; Bacterial dysentery; Infectious diarrhea","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80770059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.005
Jie Zhou, Yan Wang, Guoxing Wang
Objective To explore the clinical value of liver function indicators in predicting the severity of disease in patients with acute pancreatitis (AP), and to provide a reference for clinical treatment. Methods A retrospective study was conducted and 142 patients with acute pancreatitis were included. The disease severity was evaluated according to the RANSON score and the Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score, and severe pancreatitis was used as the outcome index. Univariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were performed on single indicators that were statistically significant between mild and severe patients to determine the distinguishing value for disease severity. Results The RANSON score was graded: 43 cases of severe patients (RANSON≥3) and 99 cases of mild patients (RANSON<3); the difference in albumin (ALB) levels between the two groups was statistically significant (P<0.05). Univariate logistic regression analysis and ROC curve analysis were performed on ALB (OR=0.88, P<0.001). The area under the ROC curve and its 95% CI were 0.73 (0.63, 0.83). APACHE Ⅱ score classification: 94 cases of severe patients (APACHE Ⅱ score≥8) and 48 cases of mild patients (APACHE Ⅱ score<8). The difference in alanine aminotransferase (ALT) levels in the two groups were statistically significant (P<0.05). Univariate factor logistic regression analysis and ROC curve analysis were performed on ALT (OR=1.001, P=0.314). The area under the ROC curve and its 95% CI were 0.61 (0.50, 0.71). Conclusions ALB and ALT are valuable biomarkers for predicting the severity of AP. Key words: Liver function tests; Acute pancreatitis; Severity of illness
{"title":"Analysis of correlation between liver function and severity of acute pancreatitis","authors":"Jie Zhou, Yan Wang, Guoxing Wang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.005","url":null,"abstract":"Objective \u0000To explore the clinical value of liver function indicators in predicting the severity of disease in patients with acute pancreatitis (AP), and to provide a reference for clinical treatment. \u0000 \u0000 \u0000Methods \u0000A retrospective study was conducted and 142 patients with acute pancreatitis were included. The disease severity was evaluated according to the RANSON score and the Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score, and severe pancreatitis was used as the outcome index. Univariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were performed on single indicators that were statistically significant between mild and severe patients to determine the distinguishing value for disease severity. \u0000 \u0000 \u0000Results \u0000The RANSON score was graded: 43 cases of severe patients (RANSON≥3) and 99 cases of mild patients (RANSON<3); the difference in albumin (ALB) levels between the two groups was statistically significant (P<0.05). Univariate logistic regression analysis and ROC curve analysis were performed on ALB (OR=0.88, P<0.001). The area under the ROC curve and its 95% CI were 0.73 (0.63, 0.83). APACHE Ⅱ score classification: 94 cases of severe patients (APACHE Ⅱ score≥8) and 48 cases of mild patients (APACHE Ⅱ score<8). The difference in alanine aminotransferase (ALT) levels in the two groups were statistically significant (P<0.05). Univariate factor logistic regression analysis and ROC curve analysis were performed on ALT (OR=1.001, P=0.314). The area under the ROC curve and its 95% CI were 0.61 (0.50, 0.71). \u0000 \u0000 \u0000Conclusions \u0000ALB and ALT are valuable biomarkers for predicting the severity of AP. \u0000 \u0000 \u0000Key words: \u0000Liver function tests; Acute pancreatitis; Severity of illness","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74914254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.010
Meiyi Lin
Objective To evaluate the relationship between angiotensin converting enzyme (ACE) and tumor necrosis factors-α (TNF-α) gene polymorphism and sarcoidosis. Methods Meta analysis was carried out by retrieving the studies published up to July 2018 to evaluate the relationship between ACE and TNF-α gene polymorphism and sarcoidosis. RevMan 5.3 and Stata 12.0 software were used to analyze the combined OR value and 95% confidence interval (95% CI) by recessive model and dominant model. The stability of the results was judged by ethnic subgroup analysis and sensitivity analysis. Results A total of 28 articles and 30 studies met the inclusion criteria, including 7 888 cases, 2 992 cases of sarcoidosis and 4 896 healthy controls. No significant association was found between ACE I/D and sarcoidosis using any model (P>0.05). TNF-α-308A/G was significantly associated with sarcoidosis risk (OR=1.34, 95% CI=1.13-1.58, P=0.0007). Ethnic subgroup analysis showed that the results were significantly different in both the Caucasians (OR=1.36, 95% CI=1.13-1.64, P=0.001) and the Asians (OR=4.88, 95% CI=1.43-16.99, P=0.01). Conclusions The meta-analysis identified that AA/AG genotypes at TNF-α-308 were associated with susceptibility to sarcoidosis .However, no significant correlation was found between ACE I/D and the susceptibility of sarcoidosis. Key words: Tumor necrosis factor-alpha; Angiotensin-converting enzyme; Gene polymorphism; Sarcoidosis; Meta-analysis
{"title":"Meta-analysis of the relationship between the polymorphism of ACE and TNF-α gene and the susceptibility of sarcoidosis","authors":"Meiyi Lin","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.010","url":null,"abstract":"Objective \u0000To evaluate the relationship between angiotensin converting enzyme (ACE) and tumor necrosis factors-α (TNF-α) gene polymorphism and sarcoidosis. \u0000 \u0000 \u0000Methods \u0000Meta analysis was carried out by retrieving the studies published up to July 2018 to evaluate the relationship between ACE and TNF-α gene polymorphism and sarcoidosis. RevMan 5.3 and Stata 12.0 software were used to analyze the combined OR value and 95% confidence interval (95% CI) by recessive model and dominant model. The stability of the results was judged by ethnic subgroup analysis and sensitivity analysis. \u0000 \u0000 \u0000Results \u0000A total of 28 articles and 30 studies met the inclusion criteria, including 7 888 cases, 2 992 cases of sarcoidosis and 4 896 healthy controls. No significant association was found between ACE I/D and sarcoidosis using any model (P>0.05). TNF-α-308A/G was significantly associated with sarcoidosis risk (OR=1.34, 95% CI=1.13-1.58, P=0.0007). Ethnic subgroup analysis showed that the results were significantly different in both the Caucasians (OR=1.36, 95% CI=1.13-1.64, P=0.001) and the Asians (OR=4.88, 95% CI=1.43-16.99, P=0.01). \u0000 \u0000 \u0000Conclusions \u0000The meta-analysis identified that AA/AG genotypes at TNF-α-308 were associated with susceptibility to sarcoidosis .However, no significant correlation was found between ACE I/D and the susceptibility of sarcoidosis. \u0000 \u0000 \u0000Key words: \u0000Tumor necrosis factor-alpha; Angiotensin-converting enzyme; Gene polymorphism; Sarcoidosis; Meta-analysis","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73303811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.012
L. Du, Bao-guo Tian, Ting Sun, Yanchun Shi, Yan Wang
Objective The aim of the study was to investigate association of response depth and prognosis in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC)patients treated with first-line tyrosine kinase inhibitors (TKIs). Methods The clinicopathological data and prognosis information of patients with locally advanced or metastatic (ⅢB or Ⅳ) lung adenocarcinoma with EGFR classical (19del or 21L858R) mutation who were treated in our hospital from 2015 to 2016 were collected. The tumor remission depth [stable disease (SD), partial response (PR), complete response (CR)] was measured by recist 1.1 standard. The survival curve was drawn by Kaplan-Meier method and log rank test was performed. Results During the study period, 204 advanced lung adenocarcinoma patients with 19del or 21L858R mutation were treated with TKI drugs of the first generation. Among them, 24 patients were lost or unable to evaluate the efficacy, 20 patients were evaluated as progression disease (PD), 62 patients as SD, 98 patients as CR or PR. Disease control rate (DCR) and objective remission rate (ORR) were 88.9% and 54.4%, respectively. The median progression free survival time (PFS) was 12.6 months (95% CI: 10.9-14.4 months) and 13.1 months (95% CI: 11.6-14.7) for patients assessed as SD (group A) and CR or PR (group B), respectively, with no significant difference (P=0.27). Subgroup analysis showed that the median overall survival of patients with EGFR 19del and 21L858R mutations was 12.5 months (95% CI: 9.9-15.4) and 12.7 months (95% CI: 9.4-16.1), respectively, with no significant difference (P=0.66); Similar result was also observed in Group B with a median PFS of 13.9 months (95% CI: 12.3-15.5 months) and 12.3 months (95% CI: 9.5-15.1 months) in patients who had EGFR 19del or 21L858R mutations (P=0.41). Conclusions Response depth was not a positive predictor for prognosis in EGFR-mutant NSCLC patients treated with first-line TKIs. Key words: Lung neoplasms; Receptor, epidermal growth factor; Tyrosine kinase inhibitors; Antineoplastic combined chemotherapy protocols; Response evaluation criteria in solid tumors
{"title":"A single center study on the relationship between the depth of remission and the efficacy of first-line TKI drugs","authors":"L. Du, Bao-guo Tian, Ting Sun, Yanchun Shi, Yan Wang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.012","url":null,"abstract":"Objective \u0000The aim of the study was to investigate association of response depth and prognosis in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC)patients treated with first-line tyrosine kinase inhibitors (TKIs). \u0000 \u0000 \u0000Methods \u0000The clinicopathological data and prognosis information of patients with locally advanced or metastatic (ⅢB or Ⅳ) lung adenocarcinoma with EGFR classical (19del or 21L858R) mutation who were treated in our hospital from 2015 to 2016 were collected. The tumor remission depth [stable disease (SD), partial response (PR), complete response (CR)] was measured by recist 1.1 standard. The survival curve was drawn by Kaplan-Meier method and log rank test was performed. \u0000 \u0000 \u0000Results \u0000During the study period, 204 advanced lung adenocarcinoma patients with 19del or 21L858R mutation were treated with TKI drugs of the first generation. Among them, 24 patients were lost or unable to evaluate the efficacy, 20 patients were evaluated as progression disease (PD), 62 patients as SD, 98 patients as CR or PR. Disease control rate (DCR) and objective remission rate (ORR) were 88.9% and 54.4%, respectively. The median progression free survival time (PFS) was 12.6 months (95% CI: 10.9-14.4 months) and 13.1 months (95% CI: 11.6-14.7) for patients assessed as SD (group A) and CR or PR (group B), respectively, with no significant difference (P=0.27). Subgroup analysis showed that the median overall survival of patients with EGFR 19del and 21L858R mutations was 12.5 months (95% CI: 9.9-15.4) and 12.7 months (95% CI: 9.4-16.1), respectively, with no significant difference (P=0.66); Similar result was also observed in Group B with a median PFS of 13.9 months (95% CI: 12.3-15.5 months) and 12.3 months (95% CI: 9.5-15.1 months) in patients who had EGFR 19del or 21L858R mutations (P=0.41). \u0000 \u0000 \u0000Conclusions \u0000Response depth was not a positive predictor for prognosis in EGFR-mutant NSCLC patients treated with first-line TKIs. \u0000 \u0000 \u0000Key words: \u0000Lung neoplasms; Receptor, epidermal growth factor; Tyrosine kinase inhibitors; Antineoplastic combined chemotherapy protocols; Response evaluation criteria in solid tumors","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83247879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.017
Jie Zhu, Liping Sun, Shizhong Wang, Jie Zhang, Meihong Wang, F. Qiao
Objective To determine interleukin (IL)-23 and IL-17 level in latent autoimmune diabetes in adult (LADA) patients, and to explore the relationship of IL-23, IL-17and β-cell function in these patients. Methods Forty LADA patients from 2011 to 2016 in our hospital were selected as LADA group, and forty participants were as normal control group. Clinical and biochemical data was collected and the level of the IL-23 and IL-17 was measured with the enzyme linked immunosorbent assay (ELISA). The differences in interleukin levels among the two groups were compared. Pearson correlation analysis was used for investigating the relationship between the dependent of statistical significant interleukins and the independent data in the LADA patients, all closely related variables then were included in a stepwise multiple linear regression analysis. Results The levels of serum IL-23 , IL-17 and IL-23/IL-17 were significantly higher in LADA group than those in control groups [3.54(2.88~5.24)μg/L vs 1.98(1.62~2.18)μg/L, P<0.05], [22.42(17.71~26.07)ng/L vs 17.97(17.15~20.70)ng/L, P<0.05], (175.79±38.67 vs 105.22±19.08, P<0.01). IL-23 and IL-17 in the LADA group were negatively correlated with fasting C peptide (FCP) (r=-0.42, r=-0.48, P<0.05), and the ratio of IL-23/IL-17 was positively correlated with fasting plasma glucose (FPG) (r=0.44, P=0.00). Stepwise multiple liner regression analysis showed that serum IL-23 and IL-17 level were independently associated with the FCP in LADA group. Conclusions IL-23 and IL-17 were possibly important proinflammatory factor in LADA patients, and can provide the new immunodiagnosis markers for LADA. Key words: Interleukin-23; Interleukin-17; Latent autoimmune diabetes in adults; C-peptide
目的检测成人潜伏性自身免疫性糖尿病(LADA)患者白细胞介素(IL)-23、IL-17水平，探讨IL-23、IL-17与LADA患者β细胞功能的关系。方法选取我院2011 ~ 2016年收治的LADA患者40例作为LADA组，40例作为正常对照组。收集临床及生化资料，采用酶联免疫吸附试验(ELISA)检测IL-23、IL-17水平。比较两组患者白细胞介素水平的差异。采用Pearson相关分析探讨LADA患者白细胞介素的依赖因子与独立数据之间的关系，将所有密切相关的变量纳入逐步多元线性回归分析。结果LADA组血清IL-23、IL-17及IL-23/IL-17水平均显著高于对照组[3.54(2.88~5.24)μg/L vs 1.98(1.62~2.18)μg/L, P<0.05]， [22.42(17.71~26.07)ng/L vs 17.97(17.15~20.70)ng/L, P<0.05]，(175.79±38.67 vs 105.22±19.08,P<0.01)。LADA组IL-23、IL-17与空腹C肽(FCP)呈负相关(r=-0.42, r=-0.48, P<0.05)， IL-23/IL-17比值与空腹血糖(FPG)呈正相关(r=0.44, P=0.00)。逐步多元线性回归分析显示，血清IL-23、IL-17水平与LADA组FCP独立相关。结论IL-23和IL-17可能是LADA患者重要的促炎因子，可为LADA提供新的免疫诊断指标。关键词:白细胞介素-23;Interleukin-17;成人潜伏性自身免疫性糖尿病;c -肽
{"title":"Analysis of the correlation between IL-23, IL-17and β-cell function in latent autoimmune diabetes in adult patients","authors":"Jie Zhu, Liping Sun, Shizhong Wang, Jie Zhang, Meihong Wang, F. Qiao","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.017","url":null,"abstract":"Objective \u0000To determine interleukin (IL)-23 and IL-17 level in latent autoimmune diabetes in adult (LADA) patients, and to explore the relationship of IL-23, IL-17and β-cell function in these patients. \u0000 \u0000 \u0000Methods \u0000Forty LADA patients from 2011 to 2016 in our hospital were selected as LADA group, and forty participants were as normal control group. Clinical and biochemical data was collected and the level of the IL-23 and IL-17 was measured with the enzyme linked immunosorbent assay (ELISA). The differences in interleukin levels among the two groups were compared. Pearson correlation analysis was used for investigating the relationship between the dependent of statistical significant interleukins and the independent data in the LADA patients, all closely related variables then were included in a stepwise multiple linear regression analysis. \u0000 \u0000 \u0000Results \u0000The levels of serum IL-23 , IL-17 and IL-23/IL-17 were significantly higher in LADA group than those in control groups [3.54(2.88~5.24)μg/L vs 1.98(1.62~2.18)μg/L, P<0.05], [22.42(17.71~26.07)ng/L vs 17.97(17.15~20.70)ng/L, P<0.05], (175.79±38.67 vs 105.22±19.08, P<0.01). IL-23 and IL-17 in the LADA group were negatively correlated with fasting C peptide (FCP) (r=-0.42, r=-0.48, P<0.05), and the ratio of IL-23/IL-17 was positively correlated with fasting plasma glucose (FPG) (r=0.44, P=0.00). Stepwise multiple liner regression analysis showed that serum IL-23 and IL-17 level were independently associated with the FCP in LADA group. \u0000 \u0000 \u0000Conclusions \u0000IL-23 and IL-17 were possibly important proinflammatory factor in LADA patients, and can provide the new immunodiagnosis markers for LADA. \u0000 \u0000 \u0000Key words: \u0000Interleukin-23; Interleukin-17; Latent autoimmune diabetes in adults; C-peptide","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87246214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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