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Serosurvey and Cellular Immune Status of HTLV-1/2 and HIV Co-infections in Bauchi State, Nigeria 尼日利亚包奇州HTLV-1/2和HIV合并感染的血清调查和细胞免疫状况
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2019.4.1
A. Babayo, Oyebanji Azeez Akande, Y. Sabo, I. Abdullahi, A. Dangana
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引用次数: 0
The Impact of ‘Stay At Home’ Orders on Emergency Room Admissions “待在家里”命令对急诊室入院人数的影响
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.2
A. Koçak, S. Doğruyol, I. Akbas, B. Kerget, Sultan Tuna Akgol Gur, Z. Çakır
Introduction. The 2019-novel-coronavirus (2019-nCoV) outbreak has become a common problem for the whole world. Aim. To investigate the impact of the 2019-nCoV pandemic period in our country on emergency room admissions. Materials and methods. The study was designed as a retrospective cohort. The first case of pneumonia infected with nCoV in our country was diagnosed on March 11, 2020. Considering the date of March 11, 2020, emergency room admissions for two periods of 7 days were investigated, pre-COVID-19 and COVID19. Demographic data, admission diagnosis, vital findings, stay times in emergency room, terminations and emergency department mortality examined. A group of ‘geriatric’ patient populations were created to examine the admission characteristics of patients aged-65 and over. Results. The 3466 patients included in the study. The average number of daily admissions was significantly higher in the pre-COVID-19 period (350.4 ± 54.5), compared to the COVID-19 period (144.7 ± 20.2, p=0001). While the proportion of cardiac-caused admissions increased during the COVID period, the proportion of gastrointestinal-induced admissions decreased (p<0001). Hospitalization rates for both adult and geriatric patients increased during the COVID period (p<0001). Conclusion. Despite all the negativity caused by the outbreak, this period has been one in which the public is aware of unnecessary emergency room which has been subsequently lessened.
介绍。新型冠状病毒(2019-nCoV)疫情已成为全球共同面临的问题。的目标。目的:探讨新型冠状病毒流行期对我国急诊入院人数的影响。材料和方法。本研究设计为回顾性队列研究。2020年3月11日,我国确诊首例新型冠状病毒感染的肺炎病例。考虑到2020年3月11日的日期,我们调查了两个为期7天的急诊室入院情况,即covid -19前和covid -19。人口统计数据,入院诊断,重要发现,在急诊室停留时间,终止和急诊科死亡率检查。创建了一组“老年”患者人群,以检查65岁及以上患者的入院特征。结果。该研究包括3466名患者。新冠肺炎前期平均每日入院人数(350.4±54.5)显著高于新冠肺炎期间(144.7±20.2,p=0001)。在COVID期间,心源性入院比例上升,胃肠道入院比例下降(p<0001)。在COVID期间,成人和老年患者的住院率均有所增加(p<0001)。结论。尽管疫情造成了所有负面影响,但这一时期是公众意识到不必要的急诊室的时期,这种急诊室后来减少了。
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引用次数: 1
Generation of retractive spine circuits in the process of vitamin B12 deficiency 维生素B12缺乏过程中产生脊柱回缩
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.2.9
P. Mucha, Natalia Leksa, D. Aebisher, Sabina Galiniak, Seweryn Bartosz, Dawid Leksa, D. Bartusik-Aebisher
Dorota Bartusik-Aebisher acknowledges support from the National Center of Science NCN (New drug delivery systems-MRI study, Grant OPUS-13 number 2017/25/B/ST4/02481).
Dorota Bartusik-Aebisher感谢NCN国家科学中心的支持(新药物输送系统- mri研究,批准OPUS-13号2017/25/B/ST4/02481)。
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引用次数: 0
Pancreatic tumor metastasis to the navel in a case with three primary tumors – case report and review of the literature 胰腺肿瘤转移至肚脐1例合并三个原发肿瘤的病例报告及文献复习
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.11
F. Dilek, Furkan Tosun, A. Atay, O. Dilek
Introduction. Sister Mary Joseph nodule (SMJN) is a metastasis that can occur in the umbilical region due to many tumors in the abdomen. Most of the cases are of gastrointestinal system origin and are often an indicator of poor prognosis. It can be seen in 1-3% of intraabdominal and pelvic malignancies. In the literature, around 300 studies are presented, mostly in the form of case reports. Very few (7-9%) of the cases with SMJN are from pancreatic origin. In our literature review, we found that in the majority (>90%) of SMJN cases due to pancreatic tumors, the lesions originated from the pancreatic tail and/or body, and tumor marker Ca-19.9 was very high in most cases (>90%). Aim. Here, the case of SMJN seen in a patient with three different primary tumors was discussed in the light of the literature data. Description of the case. Here, our case, whose third primary malignancy was detected in the pancreas in the PET/CT examination performed to investigate the origin of SMJN in a 68-year-old female patient who had undergone surgery due to breast in 2011 and endometrium cancers in 2018 and came with umbilical metastasis, is presented in the light of the literature data. Conclusion. As a result, in our case, which was followed up due to two primary tumors, it became important to know the origin of the SMJN that occurred due to the third primary tumor detected during the CT and PET/CT examination due to the newly emerging SMJN. It is important to know the origin and histopathological features of the SMJN in order to determine the treatment to the patient.
介绍。玛丽约瑟夫修女结节(SMJN)是一种转移,可发生在脐区由于许多肿瘤在腹部。大多数病例是胃肠道起源,往往是预后不良的一个指标。在1-3%的腹腔和盆腔恶性肿瘤中可见。在文献中,大约有300项研究被提出,大多以病例报告的形式。很少(7-9%)的SMJN病例来自胰腺。在我们的文献综述中,我们发现在大多数(>90%)由胰腺肿瘤引起的SMJN病例中,病变起源于胰腺尾部和/或胰腺体,大多数病例的肿瘤标志物Ca-19.9非常高(>90%)。的目标。在这里,我们结合文献资料讨论了三种不同原发肿瘤患者的SMJN病例。案件描述。本病例为探讨SMJN的起源,在2011年因乳腺癌和2018年因子宫内膜癌接受手术并伴有脐部转移的68岁女性患者的PET/CT检查中,在胰腺中发现第三原发恶性肿瘤。我们根据文献资料介绍了本病例。结论。因此,在我们的病例中,由于两个原发肿瘤而进行随访,因此了解由于新出现的SMJN而在CT和PET/CT检查中发现的第三个原发肿瘤而发生的SMJN的起源变得非常重要。重要的是了解SMJN的起源和组织病理学特征,以确定对患者的治疗。
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引用次数: 0
Multiparametric MRI and other imaging methods suitable to stage prostate carcinoma 多参数MRI等适合前列腺癌分期的影像学方法
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2019.4.7
M. Osuchowski, D. Aebisher, Sabina Galiniak, D. Bartusik-Aebisher, E. Kaznowska
Dorota Bartusik-Aebisher acknowledges support from the National Center of Science NCN (New drug delivery systems-MRI study, Grant OPUS-13 number 2017/25/B/ST4/02481).
Dorota Bartusik-Aebisher感谢NCN国家科学中心的支持(新药物输送系统- mri研究,批准OPUS-13号2017/25/B/ST4/02481)。
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引用次数: 0
Clinical application of monoclonal antibodies in targeted therapy 单克隆抗体在靶向治疗中的临床应用
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2019.4.9
Maciej Superson, Katarzyna Szmyt, K. Szymanska, K. Walczak, Jeremi Wnorowski, Łukasz Zarębski
Introduction. Recently, monoclonal antibodies (mAbs) have become powerful human therapeutics in the diagnosis and treatment of many diseases. Drugs based on mAbs are approved for the treatment of cardiovascular, respiratory, hematology, autoimmunology, and oncology diseases. Aim. To present the current state of knowledge about the application of mAbs in the therapy of various diseases such as cancer, autoimmune and Alzheimer’s diseases. Material and methods. We conducted a thorough review of the scientific literature from the following databases: EBSCO, PubMed, Science Direct, and Springer Link. Results. Currently, the Food and Drug Administration (FDA) has approved more than 50 therapeutic mAbs which are applied in various clinical trials. Action of mAb are based on various mechanisms, including directly targeting the cells, modifying the host response, recognizing and degrading molecules as well as delivering cytotoxic moieties. Conclusion. Despite some limitations including side effects, and therapeutic challenges, monoclonal antibodies are an attractive option for the development of new therapies and molecular drug targets against a wide range of common diseases due to their specificity and flexibility. MAbs are considered as a great hope for medicine, and effective and safe drugs in the treatment of various diseases.
介绍。近年来,单克隆抗体(mab)在许多疾病的诊断和治疗中已成为强有力的人类治疗手段。基于单克隆抗体的药物被批准用于心血管、呼吸、血液、自身免疫和肿瘤疾病的治疗。的目标。介绍单克隆抗体在癌症、自身免疫性疾病和阿尔茨海默病等疾病治疗中的应用现状。材料和方法。我们对EBSCO、PubMed、Science Direct和Springer Link等数据库中的科学文献进行了全面的综述。结果。目前,美国食品和药物管理局(FDA)已经批准了50多种治疗性单克隆抗体,用于各种临床试验。mAb的作用机制多种多样,包括直接靶向细胞、改变宿主反应、识别和降解分子以及传递细胞毒性部分。结论。尽管单克隆抗体存在一些局限性,包括副作用和治疗挑战,但由于其特异性和灵活性,单克隆抗体是开发针对多种常见疾病的新疗法和分子药物靶点的一个有吸引力的选择。单克隆抗体被认为是医学界的一大希望,是治疗各种疾病的有效、安全的药物。
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引用次数: 1
Knowledge, perception and child care practices among adolescent mothers in Ibadan Metropolis, Nigeria 尼日利亚伊巴丹大都会青少年母亲的知识、认知和儿童保育做法
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.4
O. Oyewole, Christiana Mautin Todowede, I. Dipeolu
Introduction. There is little information regarding childcare practices among adolescent mothers in the study areas. Aim. This study was aimed at investigating knowledge, perception and childcare practices among adolescent mothers. Material and methods. A descriptive cross-sectional survey was conducted on randomly select 382 adolescent mothers. A validated semi-structured questionnaire was used to collect data, which were analysed using, descriptive and multivariate analyses with p-value set at 0.05. Age of respondents was 18.5±0.7 years. Results. Majority (80.6%) had poor knowledge of when to start ante-natal care. Also, 70.0% of the respondents could not perceive growth monitoring as a necessary strategy for child survival and 86.4% perceived diarrhoea as normal for children during the teething period. Many (58.4%) did not practise exclusive breastfeeding. Respondents with secondary education were less likely to have poor knowledge than those with primary education (OR: 0.2, CI: 0.6-0.9, 95%). Respondents, who received supervision from older women during childcare, were less likely to have poor childcare practice than those who did not (OR: 0.2, CI: 0.4-0.7, 95%). Conclusion. Respondents had poor knowledge of childcare practices when childcare survival strategies were used as the yardstick for evaluation. Involvement of older women is suggested to assist adolescent mothers improve their knowledge and practices of childcare.
介绍。在研究地区,关于未成年母亲的育儿做法的信息很少。的目标。本研究旨在调查青少年母亲的知识、认知和育儿行为。材料和方法。采用描述性横断面调查方法,随机抽取382名青春期母亲进行调查。采用经验证的半结构化问卷收集数据,采用描述性和多变量分析进行分析,p值设置为0.05。年龄18.5±0.7岁。结果。大多数(80.6%)不知道何时开始产前护理。此外,70.0%的受访者认为生长监测不是儿童生存的必要策略,86.4%的受访者认为出牙期儿童腹泻是正常的。许多人(58.4%)没有实行纯母乳喂养。受过中等教育的受访者比受过初等教育的受访者知识贫乏的可能性更小(OR: 0.2, CI: 0.6-0.9, 95%)。在育儿期间接受老年妇女监督的受访者,其不良育儿实践的可能性低于未接受监督的受访者(OR: 0.2, CI: 0.4-0.7, 95%)。结论。当托儿生存策略被用作评估标准时,受访者对托儿实践的了解较差。建议让老年妇女参与,以帮助少女母亲提高她们的育儿知识和做法。
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引用次数: 2
Behaviors, attitudes and opinions of medical students in the field of smoking and anti-smoking counseling in two countries of Central and Eastern Europe 中欧和东欧两国医学生在吸烟和反吸烟咨询方面的行为、态度和意见
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.8
Paulina Hejda, A. Hubert-Lutecka, Z. Chmiel, A. Sidor, G. Iwanowicz-Palus, Marcin Żal, Agnieszka Koryl, M. Binkowska-Bury
Introduction. Europe is the region with the greatest proportion of deaths (16%) attributable to tobacco smoking worldwide. Medical students and physicians should set an example of tobacco-smoking abstinence for their patients. Aim. The aim of the study was to compare opinions on behaviors and attitudes of Czech and Polish medical students about tobacco smoking and the position of a physician in anti-smoking counseling. Material and methods. The Global Health Professions Student Survey (GHPSS) was conducted among 707 medical students in Czech Republic in 2011 and among 1164 medical students in Poland. Results. Twety percent of polish and 25,7% of Czech medical students declared current tobacco smoking. Eighty-one percent in Poland and 60% in Czech Republic felt that physicians should be trained in smoking cessation techniques but only 27% of the medical students in Poland and 2,8% in Czech Republic , declared that such a course had been realized during the course
介绍。欧洲是全世界吸烟导致死亡比例最高的区域(16%)。医学生和医生应该为他们的病人树立一个戒烟的榜样。的目标。本研究的目的是比较捷克和波兰医学生对吸烟的行为和态度,以及医生在反吸烟咨询中的地位。材料和方法。2011年在捷克共和国的707名医科学生和波兰的1164名医科学生中进行了全球卫生专业学生调查。结果。20%的波兰医学院学生和25.7%的捷克医学院学生称自己目前在吸烟。81%的波兰和60%的捷克共和国认为医生应该接受戒烟技术方面的培训,但只有27%的波兰医科学生和2.8%的捷克共和国医科学生宣布在课程期间实现了这一目标
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引用次数: 1
Morphology of extensor digitorum longus of Wistar rats after remobilization by vibratory platform 振动平台复位后Wistar大鼠指长伸肌形态学变化
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2019.4.2
Izabela Rodrigues Izabela Rodrigues Camilo, M. Wutzke, R. M. Costa, G. Bertolini, L. F. Ribeiro
To the Araucaria Foundation for funding with a scientifc initiation scholarship to IRC – 2018.
感谢Araucaria基金会为IRC - 2018提供科学启动奖学金。
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引用次数: 1
Knowledge of modifiable risk factors for cardiovascular diseases among university undergraduates in Ibadan, Nigeria 尼日利亚伊巴丹大学本科生对心血管疾病可改变危险因素的了解
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.7
O. Oyewole, Ayodele Solabi
Introduction. Undergraduates in many institutions live a lifestyle that could predispose them to non-communicable diseases (NCDs) including cardiovascular-related. Previous studies on modifiable risk factors (MRFs) against NCDs had focused mainly on adults, whereas young people should be prime targets for prevention programmes. Aim. This study was aimed at investigating knowledge of MRFs against cardiovascular diseases (CVDs) among university undergraduates in Ibadan, Nigeria. Material and methods. A descriptive cross-sectional design was adopted, where 500 undergraduates participated. Data were collected using Focus Group Discussion (FGD) guide and validated questionnaire. Data analyses were conducted using thematic approach and bivariate methods at 5% levels of significance, respectively. Results. Mean age was 22.8 }3.0 years and 51.4% were females. The majority reported that their fathers (82.8%) and mothers (83.0%) had no hypertension history. The FGD revealed that students were knowledgeable of MRFs and preventive behaviours but still engaged in unhealthy lifestyle practices. The MRFs identified included excessive alcohol consumption (85.4%), unhealthy diet (77.6%), physical inactivity (75.2%) and smoking (70.2%). Respondents (56.4%) had good knowledge of MRFs against CVDs; 57.0% had fair lifestyle practices and 54.8% had good knowledge of preventive behaviour against CVDs. Conclusion. Gender was significantly associated with knowledge of CVDs preventive behaviours. Institutional-based lifestyle modification programmes, using peer group education is suggested.
介绍。许多机构的本科生的生活方式可能使他们易患非传染性疾病,包括心血管相关疾病。以前关于非传染性疾病可改变风险因素(mrf)的研究主要集中在成年人身上,而年轻人应该是预防规划的主要目标。的目标。本研究旨在调查尼日利亚伊巴丹大学本科生对MRFs治疗心血管疾病(cvd)的知识。材料和方法。采用描述性横断面设计,500名大学生参与。采用焦点小组讨论(FGD)指南和有效问卷收集数据。数据分析分别采用专题方法和双变量方法,显著性水平为5%。结果。平均年龄22.8.0岁,女性占51.4%。大多数报告其父亲(82.8%)和母亲(83.0%)没有高血压病史。FGD结果显示,学生虽然了解mrf和预防行为,但仍有不健康的生活方式。确定的mrf包括过度饮酒(85.4%)、不健康饮食(77.6%)、缺乏运动(75.2%)和吸烟(70.2%)。受访者(56.4%)对心血管疾病的MRFs有很好的认识;57.0%的人有良好的生活习惯,54.8%的人有良好的心血管疾病预防知识。结论。性别与心血管疾病预防行为的知识显著相关。建议采用同侪团体教育的基于机构的生活方式改变方案。
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引用次数: 1
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临床和实验医学杂志
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