The articles in this special issue provide an important resource for researchers and clinicians in the field of depression prevention. Prevention of depression is one of the most important public health challenges today, and the articles in this issue provide a helpful overview of ways in which the field has progressed over the past decades. This article provides a brief synopsis of the articles in this special issue. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Objective: To examine short-term (i.e., postintervention) outcomes from a randomized controlled trial comparing a school-based telehealth-delivered depression prevention program, Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), to services as usual (SAU). We expected IPT-AST would be acceptable and feasible and that IPT-AST adolescents would experience greater reductions in depression symptoms, anxiety symptoms, and impairment compared with SAU.
Method: Adolescents (N = 242; Mage = 14.80 years, SD = 0.70; 65% female; 21% Black; 13% Hispanic/Latinx) with elevated scores on the Center for Epidemiologic Studies Depression Scale (Radloff, 1977) at screening provided data at baseline, 2-month (midpoint of IPT-AST), and 3-month (postintervention) assessments. They reported depression symptoms on the Center for Epidemiologic Studies Depression Scale, anxiety symptoms on the Screen for Child Anxiety Related Emotional Disorders (Birmaher et al., 1997), and impairment on the Columbia Impairment Scale (Bird et al., 1993). Baseline depression diagnosis was examined as a moderator.
Results: Hierarchical linear models showed that adolescents reported significant reductions in depression symptoms and impairment across conditions. IPT-AST adolescents reported significantly greater reductions in anxiety symptoms than SAU adolescents, d = .39, 95% CI [.05, .72], p = .003. Depression diagnosis moderated outcomes (ds = .33-.34, ps ≤ .05), such that IPT-AST adolescents without a diagnosis at baseline showed greater improvements in depression and anxiety symptoms than SAU adolescents. Adolescents in SAU with a depression diagnosis at baseline showed greater improvements in impairment compared with IPT-AST. Attendance and satisfaction data demonstrated the feasibility and acceptability of telehealth-delivered IPT-AST.
Conclusions: Results support telehealth-delivered IPT-AST as a promising intervention for improving short-term outcomes among adolescents with depression symptoms but without a depression diagnosis. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Objective: This study sought to evaluate the feasibility, acceptability, and preliminary efficacy of the Happy Older Latinos are Active (HOLA) health promotion intervention in a group of older Latinos who were at risk for developing major depressive disorder or generalized anxiety disorder.
Method: Sixty older Latinos age 60+ with subthreshold depression or anxiety were randomized to receive either HOLA (n = 30) or enhanced psychoeducation through fotonovela control (n = 30). The primary outcomes of interest were feasibility, acceptability, and reduction in depression and anxiety symptom severity. Outcome measures were administered at baseline and at the end of the intervention.
Results: Within a year, the enrollment target was met with < 5% of eligible participants refusing randomization. The randomization scheme produced equal numbers of participants randomized to each condition. Four participants (6.7%; HOLA = 1; control = 3) were lost to follow-up, 69% of the HOLA sessions were attended, and participants reported high satisfaction with the intervention. Finally, compared with control, a significant proportion of participants in HOLA experienced a clinically significant reduction in their anxiety symptoms (60% vs. 26.7%).
Conclusions: Findings highlight the feasibility, acceptability, and significant impact the HOLA intervention can have in reducing psychological distress because it is responsive, respectful, and specific to the needs of older Latinos. Furthermore, using a community health worker to deliver a health promotion intervention to prevent common mental disorders in older Latinos is an innovative approach for reducing disease burden in a population living with high disparities in accessing and engaging in mental health services. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Objective: Children of parents with severe mental illness are at increased risk of mental illness throughout their lifespan due to complex gene-environment interactions. Preventive interventions supporting parents and children are warranted. Compared with usual treatment, we tested the effectiveness of a multidisciplinary family-based preventive intervention, VIA Family.
Method: We did a parallel randomized controlled superiority trial in Copenhagen, Denmark. A total of 95 families, of 95 parents with either schizophrenia spectrum disorder (n = 12 [12.6%]), bipolar disorder (n = 25 [26.3%]), or recurrent major depressive disorder (n = 58 [61.1%]), participated. A total of 179 coparents and 113 children (6-12 years) participated. Assessments took place at baseline and after 18 months of intervention. We estimated the effects on family functioning with the McMaster Family Assessment Device and on levels of stimulation and support in the home environment with the Home Observation Measurement of the Environment.
Results: Effects on family functioning did not differ between the two groups: parents with severe mental illness (0.11; 95% CI [-0.10, 0.31]), p = .296, and coparents (-0.07; 95% CI [-0.27, 0.13]), p = .482. Assessor-rated levels of stimulation and support in the home environment improved in VIA Family, but not significantly compared with usual treatment (Mdiff: 1.79; 95% CI [-0.37, 3.95], p = .104). Sensitivity analyses confirmed our main findings.
Conclusions: Effects on family functioning and the home environment did not differ between VIA Family and usual treatment. We cannot rule out a clinically relevant effect of VIA Family on levels of stimulation and support in the home environment. Long-term follow-up will investigate potential preventive effects. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Objective: Early identification of failing psychological treatments could be of high clinical value, but therapists themselves have been found to be bad at predicting who will benefit or not. Previous research has some methodological limitations, and therapists' predictive accuracy has never been examined in internet-delivered treatments. Method: Therapists providing internet-delivered cognitive behavior therapy for depression, social anxiety disorder, and panic disorder in routine psychiatric care made outcome predictions for 897 patients during the fourth week of treatment. Therapists' accuracies were also compared to the accuracy of a simple statistical model and benchmarks for clinically acceptable/useful levels of accuracy from previous research. Results: Therapists were more accurate than chance, but their balanced accuracy was on average nine percentage points lower than the balanced accuracy of the statistical model (though confidence intervals often overlapped) and only in one case did the predictions reach the clinical acceptance and utility benchmarks. Therapists could predict on average 16% of the variance in outcome. Therapists were overly optimistic, predicting positive outcomes on average twice as often as they occurred. They differed in confidence in their predictions, though this did not affect how correct they were. Conclusions: Internet-delivered cognitive behavior therapy-therapists can often predict treatment outcomes better than chance, but generally not as well as the statistical model, and probably not accurately enough that they would be willing to act on their predictions, or that they could be used in an adaptive treatment strategy. Our previous findings suggest that patients would benefit from statistical monitoring and prediction tools in clinical settings. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Objective: This article presents primary outcomes from the Community Study of Outcome Monitoring for Emotional Disorders in Teens, a two-site, randomized controlled trial comparing the effectiveness of the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Adolescents plus measurement-based care (UP-A), measurement-based care alone (TAU+), and treatment as usual (TAU) in community mental health clinics. Method: A total of 174 clinicians were randomized to implement TAU (n = 49), TAU plus an MBC measure (TAU+; n = 63), or UP-A plus MBC (UP-A; n = 62). In addition, 196 adolescents were randomized to receive 16 weeks of either TAU (n = 68), TAU+ (n = 60), or UP-A (n = 68). Independent evaluator-, self-, and caregiver-reported adolescent anxiety and depression symptoms were measured at baseline and Weeks 8, 16, and 28 postenrollment. Results: Adolescents in all groups showed improvement over time, and compared with TAU, adolescents receiving TAU+ and UP-A conditions improved more quickly on adolescent-report measures only. There were no treatment group differences observed on independent evaluator (primary outcome) or caregiver-report measures. In post hoc analyses, moderators of treatment response included treatment duration and complexity of symptom presentation. Conclusions: In one of the largest adolescent-focused, community-located psychotherapy trials conducted in the United States, transdiagnostic treatment plus measurement-based care and measurement-based care alone conferred some adolescent-reported symptom benefits compared with treatment as usual, although adolescents in all conditions exhibited improvements in anxiety and depression. Future directions for subsequent adolescent psychotherapy effectiveness trials for anxiety and depression are discussed. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Objective: Cognitive control impairments are frequently observed after remission from depression. There is evidence to show that cognitive control training (CCT) can reduce such impairments and related risk for recurrent episodes. However, it is currently unclear how many CCT sessions are required for short- and long-term effects. Method: This randomized controlled trial investigates the dose-response relationship of CCT in a sample of individuals with remitted depression (n = 216). Participants were randomly assigned to one of six arms, each receiving a different amount of training sessions (zero, one, five, 10, 15, or 20 sessions) over the course of 4 weeks, with each session lasting 15 min. Depressive symptoms and other cognitive and emotional transfer effects were examined shortly after training, as well as at 3- and 6-month follow-up. Results: We found task-specific, but no near cognitive transfer. Mixed-effects models showed that a minimum of 10 training sessions was required for a significant decrease in depressive symptoms shortly after training with medium effect sizes, but this was not maintained at 3- or 6-month follow-up. We observed reductions in perseverative thinking in all groups receiving 10 or more CCT sessions, which remained present until 6-month follow-up. Conclusions: A minimum of 10 CCT sessions is required for beneficial effects on depressive symptoms and perseverative thinking. Where perseverative thinking remained decreased long-term, this was not the case for depressive symptoms, indicating the need for continued training or the use of booster sessions to maintain training-related improvement. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Objectives: Evidence-based psychosocial treatments for the early stages of mood or psychotic spectrum disorders are difficult to find in public health settings, and the efficacy of these treatments is limited by inconsistent behavioral skill practice among youth between sessions. Treatments can be made more accessible and efficacious when delivered through a group format that makes use of mobile applications to remind users to practice skills. Method: We conducted a 9-week, randomized controlled trial of the unified protocol (UP) for cognitive behavioral therapy (CBT) delivered via telehealth in a group format, comparing an app-enhanced version of the treatment (AppUP) to standard UP for adolescents with mood and psychotic spectrum conditions. The app was designed to help participants review session content, practice treatment skills, and log their psychiatric symptoms. Study assessors evaluated adolescents for psychiatric symptom severity and psychosocial functioning prior to treatment, at posttreatment, and 3 months posttreatment. Results: Sixty adolescents (Mage = 15.0, SD = 1.3) initiated the trial (30 were randomly assigned to each condition) with 49 retained at posttreatment (9 weeks) and 48 retained at 3 months posttreatment. Adolescents in AppUP showed greater improvements in psychosocial functioning over the 5-month study compared with those in standard UP. AppUP was also associated with greater reductions in depression severity among youth with more self-reported skill practice compared to those in standard UP. Conclusions: This study supports the benefits of transdiagnostic CBT for youth with mood and psychotic symptoms. An adjunctive app appears to improve psychosocial functioning and mood among these youth, especially among those who practice behavioral skills regularly. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Objective: Despite decades of policy emphasizing the role of evidence in guiding services, few studies have sought to improve the degree to which evidence is used in supervision and treatment. This study reports supervisor and therapist outcomes from the Reaching Families multisite cluster-randomized controlled trial, which tested the effects of a coordinated knowledge system (CKS) against practice guidelines (PG) on the use of evidence in supervision and treatment targeting low treatment engagement in publicly funded youth community mental health organizations located in two geographically distinct, underresourced communities where service inequities are common.
Method: The sample included 121 mental health professionals (92.6% female; 81.0% Black, Indigenous, and people of color1) randomly assigned to a CKS or PG control condition. We recorded, transcribed, and coded 430 supervision and 208 treatment sessions involving 221 youth (Mage = 13.1 years, 46.2% female; 78.7% Black, Indigenous, and people of color) and/or their caregivers who reported engagement concerns during therapy.
Results: CKS dyads showed uniformly greater use of evidence focused on specific client needs relative to dyads in the PG condition, with large effect sizes and no differences in the effect of condition across the sites. Secondary analyses showed that tools in the CKS condition were perceived significantly more positively than those in the PG condition in terms of effort and effectiveness, and supervisory workload was the same across both conditions.
Conclusions: In routine clinical care delivered within highly representative community settings, a strategically designed knowledge resource can improve evidence-based reasoning and action and be perceived as easy to use and useful without negatively impacting workload. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Objective: Therapists report a lack of confidence and competence in teletherapy compared to in-person therapy. Training focusing on teletherapy skills is scarce. This study reports on (a) the development of a training workshop for facilitative interpersonal skills (FIS) in teletherapy (tele-FIRST) and (b) a randomized controlled trial assessing the efficacy of tele-FIRST. Tele-FIRST is a 2-hr online synchronous training workshop that incorporates didactics, deliberate practice, simulation of teletherapy challenges, modeling, and discussion.
Method: A set of tele-FIS stimulus clips that depict four types of teletherapy challenges (e.g., emotional disconnection, distraction) was used to evaluate and train therapists' teletherapy skills. A total of 182 licensed therapists and trainees were randomized into either the tele-FIRST or a waitlist group. Of these, 153 participants completed baseline assessment and were included in the final analyses (tele-FIRST: n = 82; waitlist: n = 71). At baseline, posttraining, and follow-up, participants were assessed on their observer-rated FIS for teletherapy, self-reported FIS, teletherapy skills, acceptance of teletherapy, and self-efficacy.
Results: Therapists demonstrated increased teletherapy skills following the tele-FIRST workshop. After controlling for baseline scores, the tele-FIRST group demonstrated significantly higher observer-rated tele-FIS (ηp² = .134), self-reported FIS (ηp² = .106), teletherapy skills (ηp² = .037), acceptance of teletherapy technology (ηp² = .082), and self-efficacy (ηp² = .036) compared to the waitlist group at posttraining.
Conclusion: The tele-FIRST demonstrated significant short-term effects on enhancing therapists' teletherapy skills as rated by both independent observers and therapists themselves. Tele-FIRST may improve the quality of teletherapy, though more research is needed to investigate its long-term effects. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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