Pub Date : 2020-01-01DOI: 10.35248/2155-9554.20.11.518
K. Chan
Sensitive skin syndrome; albeit reported in many countries worldwide; remained a condition of unknown etiology and pathogenesis. Some authorities speculate it as a skin condition continuum from mild to severe, its severity is difficult to assess. Our retrospective study aimed to draw a one- year new patient’s attendee clinical data comparing the patient self -reported percepts using a validated sensitive scale questionnaire between dermatologist diagnosed skin conditions in a private clinic setting including sensitive skin syndrome. The results suggested that allergic contact dermatitis, herpes zoster and sensitive skin syndrome diagnosed patients reported a similar mean Sensitive Scale-10 scores {46.07 (N= 91), 40.72 (N=35) and 41.38 (N=84); p >0.05} respectively. The mean SS 10 score was statistically significantly different from other skin conditions like atopic dermatitis and seborrhea dermatitis and control. The patterns of percepts distribution in terms of skin irritation, general discomfort, skin itchiness, tautness and pain between allergic contact dermatitis, herpes zoster and sensitive skin syndrome were similar. Though pain is more commonly reported it herpes zoster than itch. As how a patient perceives their somatic symptoms is one of the major reasons for their dermatology health seeking behavior, our study suggested that extreme acute form of sensitive skin syndrome may have a patient percepts similar to allergic contact dermatitis, herpes zoster psychosocially significantly affecting quality of life of the sufferers.
{"title":"A Retrospective Study Comparing Patient Self Reported Percepts using aValidated Sensitive Scale Questionnaire between Dermatologist Diagnosed SkinConditions in a Private Clinic Setting including Sensitive Skin Syndrome","authors":"K. Chan","doi":"10.35248/2155-9554.20.11.518","DOIUrl":"https://doi.org/10.35248/2155-9554.20.11.518","url":null,"abstract":"Sensitive skin syndrome; albeit reported in many countries worldwide; remained a condition of unknown etiology and pathogenesis. Some authorities speculate it as a skin condition continuum from mild to severe, its severity is difficult to assess. Our retrospective study aimed to draw a one- year new patient’s attendee clinical data comparing the patient self -reported percepts using a validated sensitive scale questionnaire between dermatologist diagnosed skin conditions in a private clinic setting including sensitive skin syndrome. The results suggested that allergic contact dermatitis, herpes zoster and sensitive skin syndrome diagnosed patients reported a similar mean Sensitive Scale-10 scores {46.07 (N= 91), 40.72 (N=35) and 41.38 (N=84); p >0.05} respectively. The mean SS 10 score was statistically significantly different from other skin conditions like atopic dermatitis and seborrhea dermatitis and control. The patterns of percepts distribution in terms of skin irritation, general discomfort, skin itchiness, tautness and pain between allergic contact dermatitis, herpes zoster and sensitive skin syndrome were similar. Though pain is more commonly reported it herpes zoster than itch. As how a patient perceives their somatic symptoms is one of the major reasons for their dermatology health seeking behavior, our study suggested that extreme acute form of sensitive skin syndrome may have a patient percepts similar to allergic contact dermatitis, herpes zoster psychosocially significantly affecting quality of life of the sufferers.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"82 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74319139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2155-9554.20.11.517
M. Cavallini, M. Papagni, G. Trocchi
Objective: The purpose of this study was to provide qualitative information on the in vitro dissolution of hyaluronic acid (HA) fillers upon exposure to hyaluronidase and to determine whether in vitro sensitivity of fillers relates to clinical findings in patients treated with hyaluronidase to manage complications of HA filler placement. Methods: The authors undertook an in vitro study to evaluate how 6 types of HA fillers respond to hyaluronidase exposure. The findings were compared to outcomes in 3 clinical cases in which hyaluronidase was given to manage adverse outcomes of HA injection. Results: The fillers responded differently to the same dose of hyaluronidase. Fillers with a higher concentration of HA or a greater degree of crosslinking generally were more resistant to enzymatic dissolution. Clinical findings were consistent with in vitro results. Conclusion: The sensitivities of HA fillers to hyaluronidase in vitro were consistent with clinical findings.
{"title":"Sensitivity of Hyaluronic Acid Fillers to Hyaluronidase: An in vitro Analysis","authors":"M. Cavallini, M. Papagni, G. Trocchi","doi":"10.35248/2155-9554.20.11.517","DOIUrl":"https://doi.org/10.35248/2155-9554.20.11.517","url":null,"abstract":"Objective: The purpose of this study was to provide qualitative information on the in vitro dissolution of hyaluronic acid (HA) fillers upon exposure to hyaluronidase and to determine whether in vitro sensitivity of fillers relates to clinical findings in patients treated with hyaluronidase to manage complications of HA filler placement. Methods: The authors undertook an in vitro study to evaluate how 6 types of HA fillers respond to hyaluronidase exposure. The findings were compared to outcomes in 3 clinical cases in which hyaluronidase was given to manage adverse outcomes of HA injection. Results: The fillers responded differently to the same dose of hyaluronidase. Fillers with a higher concentration of HA or a greater degree of crosslinking generally were more resistant to enzymatic dissolution. Clinical findings were consistent with in vitro results. Conclusion: The sensitivities of HA fillers to hyaluronidase in vitro were consistent with clinical findings.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"46 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90569430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2155-9554.20.11.527
Barbara Geusen, L. Rodrigues, Rita Matias, Bárbara Tavares, A. L. Fonseca, A. M. Silva, P. Oliveira, Marta Ferreira, Dea Zhilivoda, Géraldine Lagast
Background: Available data suggests that the manifestation of aging has a strong genetic basis, which can modify an individual ‘ s susceptibility to specific skin aging signs. Proteins such as matrix metalloproteinases, aquaporins, filaggrin, superoxide dismutase and glutathione peroxidase have specific roles. Their encoding genes present single nucleotide polymorphisms resulting in different responses to skin aging for elasticity, hydration, barrier function and wrinkles. Aim: This study aimed to investigate the anti-ageing and anti-oxidant efficacy of a skin care regimen designed to address the specific needs of a certain genetic risk profile: high risk for collagen breakdown, medium risk for antioxidant production and low risk for dehydration and impaired barrier function. Methods: DNA samples of 100 participants were collected for genetic profile analysis. Of these, 24 participants presenting the most abundant genetic risk profile were enrolled on a 56 days anti-aging efficacy study of a combined treatment. The antioxidant efficacy of one investigational product was assessed for 14 participants. Results: Significant wrinkle’s depth and skin roughness improvements were found for the investigational treatment in comparison to the comparator and baseline. No variations were observed for the skin hydration and barrier function when compared to the comparator. The skin serum provided a significant antioxidant efficacy up to 24 h. Conclusion: A skin care regimen designed to address the specific needs of a genetic risk profile characterized by high risk for collagen breakdown and medium risk for low anti- oxidant production was effective on decreasing wrinkles, improving skin roughness and protecting the skin from UV oxidative damage.
{"title":"A Double Blinded, Randomized, Controlled Split-Face Study to Investigate the Efficacy of a Tailor-made Anti-Ageing Skin Care Regimen Adapted to a Genetic Skin Ageing Risk Profile","authors":"Barbara Geusen, L. Rodrigues, Rita Matias, Bárbara Tavares, A. L. Fonseca, A. M. Silva, P. Oliveira, Marta Ferreira, Dea Zhilivoda, Géraldine Lagast","doi":"10.35248/2155-9554.20.11.527","DOIUrl":"https://doi.org/10.35248/2155-9554.20.11.527","url":null,"abstract":"Background: Available data suggests that the manifestation of aging has a strong genetic basis, which can modify an individual ‘ s susceptibility to specific skin aging signs. Proteins such as matrix metalloproteinases, aquaporins, filaggrin, superoxide dismutase and glutathione peroxidase have specific roles. Their encoding genes present single nucleotide polymorphisms resulting in different responses to skin aging for elasticity, hydration, barrier function and wrinkles. Aim: This study aimed to investigate the anti-ageing and anti-oxidant efficacy of a skin care regimen designed to address the specific needs of a certain genetic risk profile: high risk for collagen breakdown, medium risk for antioxidant production and low risk for dehydration and impaired barrier function. Methods: DNA samples of 100 participants were collected for genetic profile analysis. Of these, 24 participants presenting the most abundant genetic risk profile were enrolled on a 56 days anti-aging efficacy study of a combined treatment. The antioxidant efficacy of one investigational product was assessed for 14 participants. Results: Significant wrinkle’s depth and skin roughness improvements were found for the investigational treatment in comparison to the comparator and baseline. No variations were observed for the skin hydration and barrier function when compared to the comparator. The skin serum provided a significant antioxidant efficacy up to 24 h. Conclusion: A skin care regimen designed to address the specific needs of a genetic risk profile characterized by high risk for collagen breakdown and medium risk for low anti- oxidant production was effective on decreasing wrinkles, improving skin roughness and protecting the skin from UV oxidative damage.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"14 9","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91440792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2155-9554.20.11.E110
Reszko Ae
{"title":"COVID-19 and the Dermatology","authors":"Reszko Ae","doi":"10.35248/2155-9554.20.11.E110","DOIUrl":"https://doi.org/10.35248/2155-9554.20.11.E110","url":null,"abstract":"","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"20 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78738901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Elboukhari, M. Bennani, S. Elloudi, Z. Douhi, H. Baybay, F. Mernissi, A. Amarti
Atypical fibroxanthoma, is a uncommon tumor of fibrohistiocytic mesenchymal origin, it occurs on the sun-damaged skin of elderly men. The clinical presentation is a solitary cutaneous nodule. The diagnosis is made by histology and immunohistochemistry. The large excision is the mainstay therapy and the recurrence is possible. We report a case of atypical Fibroxanthoma occurring in the scalp of a young woman.
{"title":"Atypical Fibroxanthoma of the Scalp in a Young Woman: A Case Report","authors":"K. Elboukhari, M. Bennani, S. Elloudi, Z. Douhi, H. Baybay, F. Mernissi, A. Amarti","doi":"10.46889/jdr.2020.1203","DOIUrl":"https://doi.org/10.46889/jdr.2020.1203","url":null,"abstract":"Atypical fibroxanthoma, is a uncommon tumor of fibrohistiocytic mesenchymal origin, it occurs on the sun-damaged skin of elderly men. The clinical presentation is a solitary cutaneous nodule. The diagnosis is made by histology and immunohistochemistry. The large excision is the mainstay therapy and the recurrence is possible. We report a case of atypical Fibroxanthoma occurring in the scalp of a young woman.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89481682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2155-9554.20.11.525
S. Nipanikar, V. Deshp, Cho Hs
Background: Available treatments for acne vulgaris are associated with various adverse effects, which necessitate patients to opt for alternative treatment options. Objectives: To evaluate efficacy and safety of AHPL/AYCAP/0413 capsule and AHPL/AYTOP/0213 cream in subjects suffering from Acne Vulgaris. Method: A total of 62 subjects completed the study. Subjects were advised to take 2 capsules of AHPL/AYCAP/0413 twice daily orally after meals with water and apply AHPL/AYTOP/0213 cream all over the face twice a day for two months or complete resolution of acne whichever was earlier. The primary objective was to assess changes in total number of inflammatory acne lesions on face. Secondary objectives were to assess changes in total numbers of noninflammatory acne lesions, total lesion count (inflammatory and non-inflammatory), acne severity, acne scarring, signs and symptoms, skin lightening effect, post acne dark spots, adverse events and laboratory investigations. Results: The mean inflammatory acne lesion count reduced significantly from 7.94 ± 5.91 (baseline visit) to 1.89 ± 3.06 (p=0.001) at the end of treatment. Significant reduction in total numbers of non-inflammatory acne lesions, total lesion count, acne severity and signs and symptoms of acne were observed at the end of treatment. Also improvement in skin colour, severity of post acne dark spot and reduction in numbers of post acne dark spots were observed at the end of treatment. Laboratory parameters were within normal limits both at pre and post treatment. Conclusion: AHPL/AYCAP/0413 capsule and AHPL/AYTOP/0213 cream is safe and significantly effective for treatment of acne vulgaris.
{"title":"Evaluation of Efficacy and Safety of AHPL/AYCAP/0413 Capsule and AHPL/ AYTOP/0213 Cream in Patients Suffering from Acne Vulgaris","authors":"S. Nipanikar, V. Deshp, Cho Hs","doi":"10.35248/2155-9554.20.11.525","DOIUrl":"https://doi.org/10.35248/2155-9554.20.11.525","url":null,"abstract":"Background: Available treatments for acne vulgaris are associated with various adverse effects, which necessitate patients to opt for alternative treatment options. Objectives: To evaluate efficacy and safety of AHPL/AYCAP/0413 capsule and AHPL/AYTOP/0213 cream in subjects suffering from Acne Vulgaris. Method: A total of 62 subjects completed the study. Subjects were advised to take 2 capsules of AHPL/AYCAP/0413 twice daily orally after meals with water and apply AHPL/AYTOP/0213 cream all over the face twice a day for two months or complete resolution of acne whichever was earlier. The primary objective was to assess changes in total number of inflammatory acne lesions on face. Secondary objectives were to assess changes in total numbers of noninflammatory acne lesions, total lesion count (inflammatory and non-inflammatory), acne severity, acne scarring, signs and symptoms, skin lightening effect, post acne dark spots, adverse events and laboratory investigations. Results: The mean inflammatory acne lesion count reduced significantly from 7.94 ± 5.91 (baseline visit) to 1.89 ± 3.06 (p=0.001) at the end of treatment. Significant reduction in total numbers of non-inflammatory acne lesions, total lesion count, acne severity and signs and symptoms of acne were observed at the end of treatment. Also improvement in skin colour, severity of post acne dark spot and reduction in numbers of post acne dark spots were observed at the end of treatment. Laboratory parameters were within normal limits both at pre and post treatment. Conclusion: AHPL/AYCAP/0413 capsule and AHPL/AYTOP/0213 cream is safe and significantly effective for treatment of acne vulgaris.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"55 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89113759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2155-9554.11.S7.E111
Mina Haghighiabyaneh
Dendritic cells comprise a large family of antigen-presenting cells whose cutaneous subset includes Langerhans cells, indeterminate cells, and dermal dendritic cells. These cells present antigens to lymphocytes, with whom they interact through specific surface receptors. The prototypical dendritic cell of the skin is the Langerhans cell [1]. Langerhans cells are derived from the bone marrow, are thought to locally renew in the skin, and express CD1a, S100, CD45, HLA-DR, and Langerin. A unique feature of Langerhans cells is the presence of Birbeck granules. Birbeck granules are recognized by the monoclonal antibody targeting Langerin (CD207), which acts as an endocytic receptor to translocate ligands from the cell surface into the Birbeck granule [1,2]. Indeterminate cells are morphologically and immunophenotypically similar to Langerhans cells. Various hypotheses regarding the origin of indeterminate cells have been published, but the most accepted theory is that indeterminate cells represent some variant of Langerhans cells with the lack of Birbeck granules and Langerin expression being reflective of Birbeck granules either not having developed yet in an immature precursor or having been lost after activation [2,3].
{"title":"Indeterminate Cells Histiocytosis","authors":"Mina Haghighiabyaneh","doi":"10.35248/2155-9554.11.S7.E111","DOIUrl":"https://doi.org/10.35248/2155-9554.11.S7.E111","url":null,"abstract":"Dendritic cells comprise a large family of antigen-presenting cells whose cutaneous subset includes Langerhans cells, indeterminate cells, and dermal dendritic cells. These cells present antigens to lymphocytes, with whom they interact through specific surface receptors. The prototypical dendritic cell of the skin is the Langerhans cell [1]. Langerhans cells are derived from the bone marrow, are thought to locally renew in the skin, and express CD1a, S100, CD45, HLA-DR, and Langerin. A unique feature of Langerhans cells is the presence of Birbeck granules. Birbeck granules are recognized by the monoclonal antibody targeting Langerin (CD207), which acts as an endocytic receptor to translocate ligands from the cell surface into the Birbeck granule [1,2]. Indeterminate cells are morphologically and immunophenotypically similar to Langerhans cells. Various hypotheses regarding the origin of indeterminate cells have been published, but the most accepted theory is that indeterminate cells represent some variant of Langerhans cells with the lack of Birbeck granules and Langerin expression being reflective of Birbeck granules either not having developed yet in an immature precursor or having been lost after activation [2,3].","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"3 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90387651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2155-9554.11.S7.543
Saba Shahrosv
Introduction: Keratosis Pilaris (KP) is a harmless condition of the skin.it is may be a secret on your skin for a few times. There are several types of keratosis pilaris and it has been associated with pregnancy, type 1 diabetes mellitus, obesity, dry skin, allergic diseases (e.g., Atopic dermatitis) and rarely cancer. Often the lesions can appear on the face, which may be mistaken for acne. Aim: The aim of this review was to present this condition of the skin and increase information about keratosis pilaris. Methods: A detailed electronic search was carried out on the authentic databases. Review authentic data on websites/ following patients comments for correct realization their belief form keratosis pilaris and study journals about this common skin condition. Results: In most cases, the condition gradually improves before age 30. However, it can persist longer. Physician can often diagnose keratosis pilaris simply by examining the skin; tests are not needed. Physicians will often consider family history and the presence of symptoms when making the diagnosis. Conclusion: This review suggests that • Use the soaps with suitable pH • Limit your time in the water • Avoid tight clothes You should follow the suggestions above and be patient.
{"title":"Study of Secret on your Skin","authors":"Saba Shahrosv","doi":"10.35248/2155-9554.11.S7.543","DOIUrl":"https://doi.org/10.35248/2155-9554.11.S7.543","url":null,"abstract":"Introduction: Keratosis Pilaris (KP) is a harmless condition of the skin.it is may be a secret on your skin for a few times. There are several types of keratosis pilaris and it has been associated with pregnancy, type 1 diabetes mellitus, obesity, dry skin, allergic diseases (e.g., Atopic dermatitis) and rarely cancer. Often the lesions can appear on the face, which may be mistaken for acne. Aim: The aim of this review was to present this condition of the skin and increase information about keratosis pilaris. Methods: A detailed electronic search was carried out on the authentic databases. Review authentic data on websites/ following patients comments for correct realization their belief form keratosis pilaris and study journals about this common skin condition. Results: In most cases, the condition gradually improves before age 30. However, it can persist longer. Physician can often diagnose keratosis pilaris simply by examining the skin; tests are not needed. Physicians will often consider family history and the presence of symptoms when making the diagnosis. Conclusion: This review suggests that • Use the soaps with suitable pH • Limit your time in the water • Avoid tight clothes You should follow the suggestions above and be patient.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"40 6","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91462168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2155-9554.20.11.524
N. Mian, P. Kushwaha
Xeroderma Pigmentosum (XP) a unique disorder, inherited as an autosomal recessive genodermatosis. Characterized by photosensitivity, freckly pigmented changes, premature skin ageing, telegiectasis, warty and papillomatous growth and malignant tumor development in later stage. Results from mutation in seven nucleotide excision repair gene (XPA to XP-G complement groups) and post replication repair defect (XP-Variant). This report aims to acknowledge the unique combination of XP along with neurological defects in a patient of acute myeloid leukemia.
{"title":"Xeroderma Pigmentosum with Acute Myeloid Leukemia and Meningiomas: Review of Literature","authors":"N. Mian, P. Kushwaha","doi":"10.35248/2155-9554.20.11.524","DOIUrl":"https://doi.org/10.35248/2155-9554.20.11.524","url":null,"abstract":"Xeroderma Pigmentosum (XP) a unique disorder, inherited as an autosomal recessive genodermatosis. Characterized by photosensitivity, freckly pigmented changes, premature skin ageing, telegiectasis, warty and papillomatous growth and malignant tumor development in later stage. Results from mutation in seven nucleotide excision repair gene (XPA to XP-G complement groups) and post replication repair defect (XP-Variant). This report aims to acknowledge the unique combination of XP along with neurological defects in a patient of acute myeloid leukemia.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"31 3 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77320811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2155-9554.20.11.516
Waleed Alajroush, Nouf Alqahtani, A. Alfaleh
Pyoderma Gangrenosum (PG) is an inflammatory neutrophilic dermatosis of unknown etiology, primarily sterile with no underlying infectious process and commonly present as an association with a systemic disease. It is rarely seen in pediatric age group and here we describe an atypical presentation of painless cutaneous ulcerative eruption involving the upper thighs and buttock in an otherwise healthy 14-month-old girl. Diagnosis of idiopathic PG was made based on clinical and histopathological correlation, and after excluding other etiologies including immunodeficiency and infections. The patient improved and responded well within 4 weeks of treatment with systemic corticosteroids.
{"title":"Idiopathic Pyoderma Gangrenosum in a Toddler: Case Report","authors":"Waleed Alajroush, Nouf Alqahtani, A. Alfaleh","doi":"10.35248/2155-9554.20.11.516","DOIUrl":"https://doi.org/10.35248/2155-9554.20.11.516","url":null,"abstract":"Pyoderma Gangrenosum (PG) is an inflammatory neutrophilic dermatosis of unknown etiology, primarily sterile with no underlying infectious process and commonly present as an association with a systemic disease. It is rarely seen in pediatric age group and here we describe an atypical presentation of painless cutaneous ulcerative eruption involving the upper thighs and buttock in an otherwise healthy 14-month-old girl. Diagnosis of idiopathic PG was made based on clinical and histopathological correlation, and after excluding other etiologies including immunodeficiency and infections. The patient improved and responded well within 4 weeks of treatment with systemic corticosteroids.","PeriodicalId":15448,"journal":{"name":"Journal of clinical & experimental dermatology research","volume":"4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85934888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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