Objective: Invasive meningococcal infections have a clinical picture with a rapid onset and can lead to serious sequelae and death even in individuals who are treated early. The most common causes of related epidemics are serogroups A, B, C, W, Y, and X, and two different vaccines have been developed against serogroups A, C, W, and Y and serogroup B. The serogroup B-containing MenB-4C vaccine (Bexsero®) was licensed in Turkey in 2018 and is still being administered. In this study, the side effects of this vaccine in infants and children followed up in a tertiary pediatric clinic were questioned. Materials and Methods: In our study, the local and systemic side effects of the MenB-4C vaccine doses, which were administered between March 1, 2019, and March 1, 2022, at the Child Health Follow-up Outpatient Clinic of Gazi University Faculty of Medicine, were evaluated retrospectively. All infants and children aged 0-18 years who were vaccinated at this clinic on the specified dates (n = 102) were recruited, and a questionnaire was completed by calling their parents by telephone and questioning the side effects of the vaccine. Results: It was determined that a total of 224 doses of the MenB-4C vaccine were administered to 102 children over the three-year study period, Of these vaccines, 21.6% were administered during the year before the pandemic and 78.4% during the two years after the pandemic. According to the total number of doses, the rate of local and systemic side effects was 30.8% (n= 69). It was found that among the 69 doses with side effects, 42 (60.8%) were systemic (fever), and 27 (39.1%) were local (stiffness, redness, and pain at the injection site). Side effects were observed in 41.3% of the patients after the first dose of the vaccine, 23.3% after the second dose, and 25.9% after the third dose. Conclusion: In our study, no serious post-vaccine reactions, such as anaphylaxis and encephalopathy, were observed following vaccination with MenB-4C, and the most common side effects of this vaccine were fever and local pain, which were only transient and self-limiting, lasting only two to three days at most. Since the MenB-4C vaccine, which has been included in the vaccination schedule of most countries, is a strong tool to help prevent meningococcal infections, every parent presenting to a health institution should be informed by the physician about the necessity of this vaccine, and if possible, conjugated meningococcal vaccines containing not only serogroups A, C, W, and Y but also serogroup B should be added to the national vaccine scheme.
{"title":"SIDE EFFECT PROFILE OF MENINGOCOCCAL B VACCINE IN CHILDREN","authors":"Ayşe Esra Tapci̇, Bahar Çuhacı Çakır, Aysu Duyan Çamurdan","doi":"10.16899/jcm.1373138","DOIUrl":"https://doi.org/10.16899/jcm.1373138","url":null,"abstract":"Objective: Invasive meningococcal infections have a clinical picture with a rapid onset and can lead to serious sequelae and death even in individuals who are treated early. The most common causes of related epidemics are serogroups A, B, C, W, Y, and X, and two different vaccines have been developed against serogroups A, C, W, and Y and serogroup B.\u0000The serogroup B-containing MenB-4C vaccine (Bexsero®) was licensed in Turkey in 2018 and is still being administered. In this study, the side effects of this vaccine in infants and children followed up in a tertiary pediatric clinic were questioned.\u0000Materials and Methods: In our study, the local and systemic side effects of the MenB-4C vaccine doses, which were administered between March 1, 2019, and March 1, 2022, at the Child Health Follow-up Outpatient Clinic of Gazi University Faculty of Medicine, were evaluated retrospectively. All infants and children aged 0-18 years who were vaccinated at this clinic on the specified dates (n = 102) were recruited, and a questionnaire was completed by calling their parents by telephone and questioning the side effects of the vaccine.\u0000Results: It was determined that a total of 224 doses of the MenB-4C vaccine were administered to 102 children over the three-year study period, Of these vaccines, 21.6% were administered during the year before the pandemic and 78.4% during the two years after the pandemic. According to the total number of doses, the rate of local and systemic side effects was 30.8% (n= 69). It was found that among the 69 doses with side effects, 42 (60.8%) were systemic (fever), and 27 (39.1%) were local (stiffness, redness, and pain at the injection site). Side effects were observed in 41.3% of the patients after the first dose of the vaccine, 23.3% after the second dose, and 25.9% after the third dose.\u0000Conclusion: In our study, no serious post-vaccine reactions, such as anaphylaxis and encephalopathy, were observed following vaccination with MenB-4C, and the most common side effects of this vaccine were fever and local pain, which were only transient and self-limiting, lasting only two to three days at most. Since the MenB-4C vaccine, which has been included in the vaccination schedule of most countries, is a strong tool to help prevent meningococcal infections, every parent presenting to a health institution should be informed by the physician about the necessity of this vaccine, and if possible, conjugated meningococcal vaccines containing not only serogroups A, C, W, and Y but also serogroup B should be added to the national vaccine scheme.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140513007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Summary
Objective: In this study, we aimed to compare the results of adolescent pregnancies, which we think is a big problem for our country, with young and adult pregnant women.
Material and Method: We included 15705 individuals in our retrospective cohort study. In our study, the adolescent pregnant group was 5235 people, the young adult group was 5235, and the adult group was 5235. We conducted the study at a tertiary center between January 2012 and April 2022. Before starting the study, we received the ethics committee approval of our institution, numbered KAEK/2022.04.109. We complied with the Declaration of Helsinki at all stages of the study. In the study, we compared the demographic data of the groups with the maternal and fetal outcomes of pregnancy, delivery, and postpartum.
We performed a One-Way Analysis of Variance (ANOVA) to compare group means. We used odds ratio calculation to determine risk ratios between groups. We used SPSS for Windows 24.0 (SPSS Inc., Chicago, IL, USA) for the analyses. We presented the data as mean, standard deviation, and ratio and considered them statistically significant when the P value was less than 0.05.
Result: Our study observed that the risk of having PROM in adolescent pregnant women increased approximately two times compared to adult pregnant women (aOR=01.987, 95%Cl=1.197-2454, p=0.001). When we researched the IUGR results, we found that the risk increased approximately two times in adolescent pregnant women (aOR=2.129, 95%Cl=1.754-2.947, p
总结& # x0D;目的:在本研究中，我们旨在比较青少年怀孕的结果，我们认为这是我国的一个大问题，与年轻和成年孕妇。
材料和方法:我们在回顾性队列研究中纳入了15705名个体。在我们的研究中，少女怀孕组5235人，青壮年怀孕组5235人，成年怀孕组5235人。我们于2012年1月至2022年4月在一个三级中心进行了这项研究。在开始研究之前，我们收到了我们机构伦理委员会的批准，编号为KAEK/2022.04.109。我们在研究的各个阶段都遵守了《赫尔辛基宣言》。在这项研究中，我们比较了两组的人口统计学数据，包括妊娠、分娩和产后的母胎结局。
我们进行了单向方差分析(ANOVA)来比较组均值。我们使用优势比计算来确定组间的风险比。我们使用SPSS for Windows 24.0 (SPSS Inc.， Chicago, IL, USA)进行分析。我们以平均值、标准差和比率表示数据，当P值小于0.05时，认为它们具有统计学意义。
结果:我们的研究发现，青春期孕妇发生胎膜早破的风险比成年孕妇增加了约2倍(aOR= 1.987, 95%Cl=1.197-2454, p=0.001)。当我们研究IUGR结果时，我们发现青春期孕妇的风险增加了大约两倍(aOR=2.129, 95%Cl=1.754-2.947, p
{"title":"Üçüncü basamak olan kliniğimizde on yıl boyunca adolesan gebeler, genç yetişkin gebeler ve yetişkin gebelerin arasında gebelik sonuçlarının karşılaştırılması","authors":"Ömer ÜNAL","doi":"10.16899/jcm.1350938","DOIUrl":"https://doi.org/10.16899/jcm.1350938","url":null,"abstract":"Summary 
 Objective: In this study, we aimed to compare the results of adolescent pregnancies, which we think is a big problem for our country, with young and adult pregnant women.
 Material and Method: We included 15705 individuals in our retrospective cohort study. In our study, the adolescent pregnant group was 5235 people, the young adult group was 5235, and the adult group was 5235. We conducted the study at a tertiary center between January 2012 and April 2022. Before starting the study, we received the ethics committee approval of our institution, numbered KAEK/2022.04.109. We complied with the Declaration of Helsinki at all stages of the study. In the study, we compared the demographic data of the groups with the maternal and fetal outcomes of pregnancy, delivery, and postpartum.
 We performed a One-Way Analysis of Variance (ANOVA) to compare group means. We used odds ratio calculation to determine risk ratios between groups. We used SPSS for Windows 24.0 (SPSS Inc., Chicago, IL, USA) for the analyses. We presented the data as mean, standard deviation, and ratio and considered them statistically significant when the P value was less than 0.05.
 Result: Our study observed that the risk of having PROM in adolescent pregnant women increased approximately two times compared to adult pregnant women (aOR=01.987, 95%Cl=1.197-2454, p=0.001). When we researched the IUGR results, we found that the risk increased approximately two times in adolescent pregnant women (aOR=2.129, 95%Cl=1.754-2.947, p","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136342849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aim: We aimed to find out whether there is any delay in the management of the process in patients operated on for lung cancer and to understand the effect of intraoperative frozen section on this process.
Methods: 176 patients were analyzed in total. The dates of admission, diagnosis, operation, and postoperative pathology results were noted. Five intervals were defined as time from first evaluation to diagnosis, first evaluation to surgery, diagnosis to surgery, first evaluation to the day of the postoperative pathology report, and diagnosis to the day of the postoperative pathology report.
Results: The majority of patients (81.8%) were male, and the median age was 63 years (iqr = 11). The median time between the first assessment and the final pathological examination result was 62 days (iqr = 70). The time from initial presentation to surgery was significantly shorter (p 0.001), and the time from diagnosis to final pathology was also significantly shorter (p 0.001) in patients diagnosed by frozen section. However, there was no significant difference in the time from initial evaluation to diagnosis between the two groups (0.052). There was no significant difference in survival between patients diagnosed by freezing and patients diagnosed by other methods (p = 0.508).
Conclusion: Solutions to increase the timeliness of care for patients with lung cancer can be designed with a better understanding of delays. Intraoperative frozen section diagnosis improves overall timeliness but has no effect on survival in lung cancer patients undergoing surgery.
{"title":"Evaluation of the effect of intraoperative frozen section on overall timeliness and survival in lung cancer surgery","authors":"Merve ŞENGÜL İNAN, Kubilay İNAN, İlknur AYTEKİN ÇELİK, Nurettin KARAOGLANOGLU","doi":"10.16899/jcm.1347963","DOIUrl":"https://doi.org/10.16899/jcm.1347963","url":null,"abstract":"Background/Aim: We aimed to find out whether there is any delay in the management of the process in patients operated on for lung cancer and to understand the effect of intraoperative frozen section on this process.
 
 Methods: 176 patients were analyzed in total. The dates of admission, diagnosis, operation, and postoperative pathology results were noted. Five intervals were defined as time from first evaluation to diagnosis, first evaluation to surgery, diagnosis to surgery, first evaluation to the day of the postoperative pathology report, and diagnosis to the day of the postoperative pathology report.
 
 Results: The majority of patients (81.8%) were male, and the median age was 63 years (iqr = 11). The median time between the first assessment and the final pathological examination result was 62 days (iqr = 70). The time from initial presentation to surgery was significantly shorter (p 0.001), and the time from diagnosis to final pathology was also significantly shorter (p 0.001) in patients diagnosed by frozen section. However, there was no significant difference in the time from initial evaluation to diagnosis between the two groups (0.052). There was no significant difference in survival between patients diagnosed by freezing and patients diagnosed by other methods (p = 0.508).
 
 Conclusion: Solutions to increase the timeliness of care for patients with lung cancer can be designed with a better understanding of delays. Intraoperative frozen section diagnosis improves overall timeliness but has no effect on survival in lung cancer patients undergoing surgery.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136343435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aim:Evaluation of the relationship between drugs and osteoporosis in patients receiving entecavir (ETV) or tenofovir disoproxil fumarate (TDF) treatment for chronic hepatitis B infection (CHB).
Material and Method: The study included patients who received ETV or TDF treatment for at least 12 months between 2016 and 2021 and underwent bone mineral densitometry (BMD) measurement within 12 months after treatment. Demographic characteristics of the patients and the association of antiviral drug use with osteopenia/osteoporosis were retrospectively.
Results: The study included 170 patients, 92 (54.1%) of whom were male, with a mean age at diagnosis of 36.57 ± 14.88 years. Of the patients, 24 (14.1%) were on ETV and 146 (85.9%) were on TDF. The mean age at BMD measurement was 48.62 ± 13.4 years. The median time from diagnosis to BMD was 138.5 (15-373) months. Osteopenia/osteoporosis was found in 14 (15.2%) of male patients and 25 (32.1%) of female patients. The frequency of osteopenia/osteoporosis was significantly higher in women (p=0.011). There was no significant difference in the frequency of osteopenia/osteoporosis between ETV and TDF (p=0.112). Lumbar spine (LS) BMD was significantly higher in TDF users (p=0.043). While no patient had a BMD within 12 months of treatment initiation, 6 (3.5%) of the patients had a BMD within 24 months, 8 (4.7%) within 36 months and 25 (14.7%) within 60 months of treatment initiation.
Conclusion: There was no significant difference in the development of osteopenia/osteoporosis in patients using TDF and ETV. It was found that bone mineral measurements of patients with CHB were not performed regularly and appropriately.
{"title":"The Effect of Entecavir and Tenofovir Disoproxil on Bone Mineral Density in Chronic Hepatitis B Treatment","authors":"Yasemin EMÜR GÜNAY, Arif Mansur COŞAR","doi":"10.16899/jcm.1355833","DOIUrl":"https://doi.org/10.16899/jcm.1355833","url":null,"abstract":"Background/Aim:Evaluation of the relationship between drugs and osteoporosis in patients receiving entecavir (ETV) or tenofovir disoproxil fumarate (TDF) treatment for chronic hepatitis B infection (CHB).
 Material and Method: The study included patients who received ETV or TDF treatment for at least 12 months between 2016 and 2021 and underwent bone mineral densitometry (BMD) measurement within 12 months after treatment. Demographic characteristics of the patients and the association of antiviral drug use with osteopenia/osteoporosis were retrospectively.
 Results: The study included 170 patients, 92 (54.1%) of whom were male, with a mean age at diagnosis of 36.57 ± 14.88 years. Of the patients, 24 (14.1%) were on ETV and 146 (85.9%) were on TDF. The mean age at BMD measurement was 48.62 ± 13.4 years. The median time from diagnosis to BMD was 138.5 (15-373) months. Osteopenia/osteoporosis was found in 14 (15.2%) of male patients and 25 (32.1%) of female patients. The frequency of osteopenia/osteoporosis was significantly higher in women (p=0.011). There was no significant difference in the frequency of osteopenia/osteoporosis between ETV and TDF (p=0.112). Lumbar spine (LS) BMD was significantly higher in TDF users (p=0.043). While no patient had a BMD within 12 months of treatment initiation, 6 (3.5%) of the patients had a BMD within 24 months, 8 (4.7%) within 36 months and 25 (14.7%) within 60 months of treatment initiation.
 Conclusion: There was no significant difference in the development of osteopenia/osteoporosis in patients using TDF and ETV. It was found that bone mineral measurements of patients with CHB were not performed regularly and appropriately.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136343728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Endoscopy is recommended in acute upper gastrointestinal bleeding (AUGIB) to detect the bleeding source and stop the bleeding. The optimal timing of endoscopy in AUGIB is controversial. We aimed to investigate the time of endoscopy and the factors affecting it.
Materials and methods: Retrospective, single-center study. The patients were divided into four groups: endoscopy after discharge, 0-12 hours endoscopy, 12-24 hours endoscopy and 24 hours later. Age, sex, vital signs, laboratory findings were recorded. Glasgow-Blatchford Score (GBS) and Charlson comorbidity index (CCI) were calculated. The obtained data were compared between these four groups. All-cause mortality for 30 days was recorded.
Results: A total of 318 patients were included. In the comparison of endoscopy times, the parameters found to be statistically significant between the four groups are Hb, BUN, and INR levels, GBS and CCI. As a result of CHAID analysis, the most crucial variable affecting the timing of endoscopy was found to be the Hb value of the patients (χ2=66.528; adjusted p=0.000). Mortality occurred in 10.69% of the patients. The timing of endoscopy did not affect mortality. In binary logistic regression analysis, low systolic BP (0.967 times increase), high CCI (86,402 times increase) were found to affect mortality.
Conclusion: The factors affecting the timing of endoscopy are the signs of bleeding. A thorough follow-up of vital signs in patients presenting to the emergency department with acute gastrointestinal bleeding, particularly an evaluation of systolic blood pressure and detailed questioning of additional comorbid conditions, is critical to reduce mortality.
{"title":"Akut Üst Gastrointestinal Kanama İle Başvuran Hastaların Endoskopi Yapılma Zamanının Hastaların Mortalitesine Etkileri","authors":"Guner YURTSEVER","doi":"10.16899/jcm.1341380","DOIUrl":"https://doi.org/10.16899/jcm.1341380","url":null,"abstract":"Background: Endoscopy is recommended in acute upper gastrointestinal bleeding (AUGIB) to detect the bleeding source and stop the bleeding. The optimal timing of endoscopy in AUGIB is controversial. We aimed to investigate the time of endoscopy and the factors affecting it.
 Materials and methods: Retrospective, single-center study. The patients were divided into four groups: endoscopy after discharge, 0-12 hours endoscopy, 12-24 hours endoscopy and 24 hours later. Age, sex, vital signs, laboratory findings were recorded. Glasgow-Blatchford Score (GBS) and Charlson comorbidity index (CCI) were calculated. The obtained data were compared between these four groups. All-cause mortality for 30 days was recorded.
 Results: A total of 318 patients were included. In the comparison of endoscopy times, the parameters found to be statistically significant between the four groups are Hb, BUN, and INR levels, GBS and CCI. As a result of CHAID analysis, the most crucial variable affecting the timing of endoscopy was found to be the Hb value of the patients (χ2=66.528; adjusted p=0.000). Mortality occurred in 10.69% of the patients. The timing of endoscopy did not affect mortality. In binary logistic regression analysis, low systolic BP (0.967 times increase), high CCI (86,402 times increase) were found to affect mortality.
 Conclusion: The factors affecting the timing of endoscopy are the signs of bleeding. A thorough follow-up of vital signs in patients presenting to the emergency department with acute gastrointestinal bleeding, particularly an evaluation of systolic blood pressure and detailed questioning of additional comorbid conditions, is critical to reduce mortality.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136343802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Understanding HPV and cervical cancer is vital for prevention, early diagnosis, and treatment. Nurses play a crucial role in implementing screening and are also at risk. This study examines nurses' knowledge and practices regarding HPV and cervical cancer screening in a tertiary center.
Materials and Methods: It is a prospective survey study conducted with nurses. A total of 191 nurses participated in the three-part and 53-item survey that evaluated demographic data, HPV knowledge levels and cervical cancer screening awareness.
Results: A total of 2895 nurses work at the hospital. The rate of participation in the research was 6.6% with 191 participants. The average age of the participants is 27.1. Majority of the participants are female (n: 171, 89.5%), only 20 (10.5%) are male. While 81.9% of the respondents had knowledge about sexually transmitted diseases, only 13.5% had gone to regular gynecological examinations. Despite 98.4% of the participants who had knowledge about cervical cancer and screening practices, only 11% (n:19) had undergone cervical cancer screening and 94.2% (n:180) had not received HPV vaccine. The most mis-answered question about HPV was whether current vaccines protect against both genital warts and cervical cancer.
Conclusion: In conclusion, nurses' knowledge level and screening practices about HPV and cervical cancer need to be improved. It is also important to increase awareness of the HPV vaccine and encourage more people to receive it. This effort could positively impact health outcomes related to cervical cancer and HPV.
{"title":"Knowledge level about HPV infection and cervical cancer screening tests","authors":"Merve ALDIKAÇTIOĞLU TALMAÇ, Nazlı Aylin VURAL, Zeliha Zeynep SATILMIŞOĞLU, Füreya Zilal HOCAGİL, Merve ATASOY RUSEN, Nilüfer ÇETİNKAYA","doi":"10.16899/jcm.1347031","DOIUrl":"https://doi.org/10.16899/jcm.1347031","url":null,"abstract":"Introduction: Understanding HPV and cervical cancer is vital for prevention, early diagnosis, and treatment. Nurses play a crucial role in implementing screening and are also at risk. This study examines nurses' knowledge and practices regarding HPV and cervical cancer screening in a tertiary center.
 Materials and Methods: It is a prospective survey study conducted with nurses. A total of 191 nurses participated in the three-part and 53-item survey that evaluated demographic data, HPV knowledge levels and cervical cancer screening awareness.
 Results: A total of 2895 nurses work at the hospital. The rate of participation in the research was 6.6% with 191 participants. The average age of the participants is 27.1. Majority of the participants are female (n: 171, 89.5%), only 20 (10.5%) are male. While 81.9% of the respondents had knowledge about sexually transmitted diseases, only 13.5% had gone to regular gynecological examinations. Despite 98.4% of the participants who had knowledge about cervical cancer and screening practices, only 11% (n:19) had undergone cervical cancer screening and 94.2% (n:180) had not received HPV vaccine. The most mis-answered question about HPV was whether current vaccines protect against both genital warts and cervical cancer. 
 Conclusion: In conclusion, nurses' knowledge level and screening practices about HPV and cervical cancer need to be improved. It is also important to increase awareness of the HPV vaccine and encourage more people to receive it. This effort could positively impact health outcomes related to cervical cancer and HPV.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136342737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Proverb comprehension was tested in 22 patients with primary progressive aphasia utilizing idiom explanation task. The aim of this study was to determine proverb comprehension in PPA patients using the Proverb Scale.
Material and Methods: To assess the participants, Montreal Cognitive Assessment Scale, the Pyramid and Palm Trees test and the Proverb Scale were used.
Results: As a result of statistical analysis, there was a significantly difference between svPPA and lvPPA regarding idiom comprehension scores, the Pyramid and Palm Trees Test Scores and MoCA scores.
Conclusion: It is an important study to understand how the abstraction in PPA works regarding the language. In PPA subtypes, semantic memory, proverb and MoCA scores were significantly different between logopenic and semantic variants. Although MoCA and proverb comprehension were correlated in svPPA, no correlation was found in lvPPA. With similar studies in the field, it would be possible to better explain the effects of PPA, a disorder characterized by language disorders.
{"title":"Proverb Comprehension in Primary Progressive Aphasia","authors":"İbrahim Can YAŞA, Fenise Selin KARALI","doi":"10.16899/jcm.1331649","DOIUrl":"https://doi.org/10.16899/jcm.1331649","url":null,"abstract":"Aim: Proverb comprehension was tested in 22 patients with primary progressive aphasia utilizing idiom explanation task. The aim of this study was to determine proverb comprehension in PPA patients using the Proverb Scale. 
 Material and Methods: To assess the participants, Montreal Cognitive Assessment Scale, the Pyramid and Palm Trees test and the Proverb Scale were used. 
 Results: As a result of statistical analysis, there was a significantly difference between svPPA and lvPPA regarding idiom comprehension scores, the Pyramid and Palm Trees Test Scores and MoCA scores. 
 Conclusion: It is an important study to understand how the abstraction in PPA works regarding the language. In PPA subtypes, semantic memory, proverb and MoCA scores were significantly different between logopenic and semantic variants. Although MoCA and proverb comprehension were correlated in svPPA, no correlation was found in lvPPA. With similar studies in the field, it would be possible to better explain the effects of PPA, a disorder characterized by language disorders.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136342738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aims: Caregivers are family members who provide unpaid assistance to their ill spouses. In Turkey, family caregiving, engagement, and support are needed when patients are hospitalized. This study aims to better understand the feelings of caregivers behind their behaviors in a terrier palliative care setting.
Methods: This research is a cross-sectional qualitative study designed with phenomenology. Five family caregivers who volunteered to participate were interviewed face-to-face. Inclusion criteria were adult informal caregivers who currently provided care to the patient at home and in the hospital.
Results: The family caregivers consist of five spouses with a mean age of 44.8 ± 4.80 years. Each caregiver is a female and the spouse of the patient. Of the patients diagnosis was Alzheimer’s disease, dementia, gastric cancer, and stroke, respectively. The caregiving time was approximately 2.79 ± 1.62 years. Four themes and eleven subthemes were indicated: Concerns about themselves: Overestimating their health care problems, Anxiety about staying strong; Consequences of the patient: Remembering the patient like a “hero”; Acceptance of the situation Fear of “finding him death” Challenges about caregiving Sacrificing from life Excessive responsibility Embarrassment from diaper care Lack of orientation for caregiving at first Coping strategies Devine providence Religious beliefs.
Conclusions: The findings of the study indicate that family caregivers have concerns about themselves and the consequences of their roles. Even if they try to cope with spirituality, healthcare providers can support them by recognizing their essential roles.
{"title":"‘Ya Ondan Önce Ölürsem?' Palyatif Bakımda Bakımverenlerin Endişeleri","authors":"Canan TUZ, Alis ÖZÇAKIR","doi":"10.16899/jcm.1345365","DOIUrl":"https://doi.org/10.16899/jcm.1345365","url":null,"abstract":"Background/Aims: Caregivers are family members who provide unpaid assistance to their ill spouses. In Turkey, family caregiving, engagement, and support are needed when patients are hospitalized. This study aims to better understand the feelings of caregivers behind their behaviors in a terrier palliative care setting. 
 Methods: This research is a cross-sectional qualitative study designed with phenomenology. Five family caregivers who volunteered to participate were interviewed face-to-face. Inclusion criteria were adult informal caregivers who currently provided care to the patient at home and in the hospital. 
 Results: The family caregivers consist of five spouses with a mean age of 44.8 ± 4.80 years. Each caregiver is a female and the spouse of the patient. Of the patients diagnosis was Alzheimer’s disease, dementia, gastric cancer, and stroke, respectively. The caregiving time was approximately 2.79 ± 1.62 years. Four themes and eleven subthemes were indicated: Concerns about themselves: Overestimating their health care problems, Anxiety about staying strong; Consequences of the patient: Remembering the patient like a “hero”; Acceptance of the situation Fear of “finding him death” Challenges about caregiving Sacrificing from life Excessive responsibility Embarrassment from diaper care Lack of orientation for caregiving at first Coping strategies Devine providence Religious beliefs. 
 Conclusions: The findings of the study indicate that family caregivers have concerns about themselves and the consequences of their roles. Even if they try to cope with spirituality, healthcare providers can support them by recognizing their essential roles.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136342887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meltem GÜMÜŞ, Alaaddin YORULMAZ, Hakan CANDAN, Mehmet ÖZTÜRK, Fuat BUĞRUL, Halil Haldun EMİROĞLU
Aim:We aimed to investigate the clinical significance and diagnostic value of inflammation-based biomarkers in children with a diagnosis of Metabolic Dysfunction Associated Steatotic Liver Disease(MASLD).
Methods:This study was carried out by retrospectively evaluating the files of patients followed up in the Department of Pediatric Hepatology at xxUniversity between July 2022 and January 2023.The study was completed with 120 patients with MASLD diagnosed according to the criteria of the AASLD and EASL, 80 healthy controls.Comparisons were made by calculating laboratory values and formulas through them.
Results:There were 50(41.7%)girls and 70(58.3%)boys in the patient group,and 40 girls (50.0%) and 40 boys(50.0%) in the control group.While 80 patients with Grade 0 detected in liver ultrasonography were taken as the control group;102(85%) Grade 1 and 18(15%)Grade 2-3 patients were considered as the patient group.The values of the patients were compared with the values of healthy volunteers.When the WBC, neutrophil, lymphocyte, platelet, MHR, RPR, RLR, MPR, WMR, GPR, SII and FIB-4score values were compared according to liver grading, a correlation was found in the tests performed on the patients.
Conclusion:Our study suggests that the presence of MASLD should be investigated in individuals, and possible complications can be prevented with early diagnosis and treatment approaches.As a result, we think that the use of hematological biomarkers will be useful for the simple and rapid detection of patients with suspected MASLD and who need further examination and treatment.
{"title":"Çocukluk Çağı Metabolik Disfonksiyonla İlişkili Steatotik Karaciğer Hastalığında Hematolojik Biyobelirteçlerin Değerlendirilmesi","authors":"Meltem GÜMÜŞ, Alaaddin YORULMAZ, Hakan CANDAN, Mehmet ÖZTÜRK, Fuat BUĞRUL, Halil Haldun EMİROĞLU","doi":"10.16899/jcm.1332759","DOIUrl":"https://doi.org/10.16899/jcm.1332759","url":null,"abstract":"Aim:We aimed to investigate the clinical significance and diagnostic value of inflammation-based biomarkers in children with a diagnosis of Metabolic Dysfunction Associated Steatotic Liver Disease(MASLD).
 Methods:This study was carried out by retrospectively evaluating the files of patients followed up in the Department of Pediatric Hepatology at xxUniversity between July 2022 and January 2023.The study was completed with 120 patients with MASLD diagnosed according to the criteria of the AASLD and EASL, 80 healthy controls.Comparisons were made by calculating laboratory values and formulas through them.
 Results:There were 50(41.7%)girls and 70(58.3%)boys in the patient group,and 40 girls (50.0%) and 40 boys(50.0%) in the control group.While 80 patients with Grade 0 detected in liver ultrasonography were taken as the control group;102(85%) Grade 1 and 18(15%)Grade 2-3 patients were considered as the patient group.The values of the patients were compared with the values of healthy volunteers.When the WBC, neutrophil, lymphocyte, platelet, MHR, RPR, RLR, MPR, WMR, GPR, SII and FIB-4score values were compared according to liver grading, a correlation was found in the tests performed on the patients.
 Conclusion:Our study suggests that the presence of MASLD should be investigated in individuals, and possible complications can be prevented with early diagnosis and treatment approaches.As a result, we think that the use of hematological biomarkers will be useful for the simple and rapid detection of patients with suspected MASLD and who need further examination and treatment.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136343658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract
Aim: Despite numerous advances in treating acute lymphoblastic leukemia (ALL) in children, relapse continues to be the leading cause of mortality. This study aimed to analyze the data of patient’s characteristics, and outcomes of children with relapsed ALL.
Material and Method: We retrospectively analyzed the records of patients aged 1–18 years diagnosed with relapsed ALL between January 2004 and December 2018.
Results: 452 ALL patients followed up in the study period and 55 patients relapsed. The relap-se rate was 12.1%. Thirty-four (61.8%) of the relapsed patients were male. The median age was seven years (1–17 years). Forty-six patients (83.6%) had precursor B-cell ALL and nine pati-ents (16.3%) had T-cell ALL. The site of relapse was bone marrow in 41 patients (74.5%), and extramedullary (central nervous system, testis, or soft tissue) in 11 patients (20%). The mean duration from the initial diagnosis to relapse was 32 months ( min-max: 4 -108 months, SD±21.2) and 20 months (min-max: 7-38 months, SD± 11.1) in patients with B- cell ALL and T- cell ALL respectively. The median follow-up time was 39.8 months (min-max: 3–198 months, SD±44.5) from the initial diagnosis. Thirty-seven patients (67.3%) died. The 5-year overall survival rate was 41.6%. Recurrent relapse and progressive disease were the most com-mon causes of death. The mortality rate was significantly associated with the immunophenotype, treatment response on days 8, 15, and 33 of initial diagnosis, the risk group at initial diagnosis, the site of relapse, and hematopoietic stem cell transplantation (p
{"title":"Nüks Eden Akut Lenfoblastik Lösemili Düşük ve Orta Gelirli Çocukların Sonuçları: Tek Merkez Deneyimi","authors":"Zeliha GUZELKUCUK, Özlem ARMAN BİLİR, İkbal OK BOZKAYA, Dilek KAÇAR, Melek ISİK, Dilek GÜRLEK GÖKÇEBAY, Namık Yaşar ÖZBEK, Hüsniye Neşe YARALI","doi":"10.16899/jcm.1345525","DOIUrl":"https://doi.org/10.16899/jcm.1345525","url":null,"abstract":"Abstract
 Aim: Despite numerous advances in treating acute lymphoblastic leukemia (ALL) in children, relapse continues to be the leading cause of mortality. This study aimed to analyze the data of patient’s characteristics, and outcomes of children with relapsed ALL.
 Material and Method: We retrospectively analyzed the records of patients aged 1–18 years diagnosed with relapsed ALL between January 2004 and December 2018.
 Results: 452 ALL patients followed up in the study period and 55 patients relapsed. The relap-se rate was 12.1%. Thirty-four (61.8%) of the relapsed patients were male. The median age was seven years (1–17 years). Forty-six patients (83.6%) had precursor B-cell ALL and nine pati-ents (16.3%) had T-cell ALL. The site of relapse was bone marrow in 41 patients (74.5%), and extramedullary (central nervous system, testis, or soft tissue) in 11 patients (20%). The mean duration from the initial diagnosis to relapse was 32 months ( min-max: 4 -108 months, SD±21.2) and 20 months (min-max: 7-38 months, SD± 11.1) in patients with B- cell ALL and T- cell ALL respectively. The median follow-up time was 39.8 months (min-max: 3–198 months, SD±44.5) from the initial diagnosis. Thirty-seven patients (67.3%) died. The 5-year overall survival rate was 41.6%. Recurrent relapse and progressive disease were the most com-mon causes of death. The mortality rate was significantly associated with the immunophenotype, treatment response on days 8, 15, and 33 of initial diagnosis, the risk group at initial diagnosis, the site of relapse, and hematopoietic stem cell transplantation (p","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136343791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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