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Glycemic responses of local beans (Vigna unguiculata [Linn Walp] varieties) in persons with Type 2 diabetes mellitus and healthy controls - An experimental study 当地豆类(Vigna unguiculata [Linn Walp]品种)对2型糖尿病患者和健康对照者的血糖反应-一项实验研究
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2020-10-01 DOI: 10.4103/jcls.jcls_61_19
O. Olopade, I. Odeniyi, O. Fasanmade, B. Olopade, Oluwatosin O. Kayode, A. Anyanwu, P. Chimah
Background: Medical nutrition therapy is an important aspect of managing diabetes mellitus (DM). Foods with low glycemic index are encouraged in individuals with DM. Despite the good glycemic indices associated with beans, glycemic responses of bean meals in persons with DM is unknown. The aim of this study is to determine whether there are differences in the glycemic responses of local beans (Vigna unguiculata [Linn Walp] varieties) in persons with Type 2 DM (T2DM) and healthy controls. Methods: This was an experimental study done at Lagos University Teaching Hospital over 12 weeks. Twelve consenting T2DM persons and 12 healthy controls participated in this study. Peak plasma glucose (PPG), the maximum increase in plasma glucose (MIPG), 2-h postprandial glucose (2HPPG), and incremental area under glucose curve (IAUGC) of three different varieties (V. unguiculata [Linn Walp] varieties) “oloyin,” “drum” and “sokoto white” were measured. Results: Among healthy participants “Oloyin” bean meal had the lowest values of PPG, MIPG, and IAUGC, while “drum” bean meal had the highest values of MIPG and IAUGC (P = 0.039). Among persons with DM, “Oloyin” bean meal had the highest 2HPPG, PPG but lowest MIPG values when compared with other bean meals while “drum” bean meal had the highest MIPG and IAUGC with the lowest 2HPPG of the three-bean meals. Conclusion: There were differences in the glycaemic responses of V. unguiculata (Linn Walp) varieties studied in persons with T2DM and controls. Glycaemic responses, in addition to glycemic indices of meals, should be considered in the management of persons with DM.
背景:医学营养治疗是糖尿病治疗的一个重要方面。糖尿病患者建议食用低血糖指数的食物。尽管豆类具有良好的血糖指数,但糖尿病患者食用豆粕的血糖反应尚不清楚。本研究的目的是确定当地豆类(Vigna unguiculata [Linn Walp]品种)在2型糖尿病(T2DM)患者和健康对照者的血糖反应是否存在差异。方法:在拉各斯大学教学医院进行为期12周的实验研究。12名同意T2DM患者和12名健康对照者参加了本研究。测定了3个不同品种(马蹄莲[Linn Walp]品种)“oloyin”、“drum”和“sokoto white”的峰值血浆血糖(PPG)、最大血浆血糖升高(MIPG)、餐后2 h血糖(2HPPG)和葡萄糖曲线下增量面积(IAUGC)。结果:健康受试者中,“Oloyin”豆粕的PPG、MIPG和IAUGC值最低,“drum”豆粕的MIPG和IAUGC值最高(P = 0.039)。在DM人群中,“Oloyin”豆粕的2HPPG、PPG值最高,但MIPG值最低;“drum”豆粕的MIPG和IAUGC值最高,但2HPPG值最低。结论:在T2DM患者和对照组中,研究了不同种类的马蹄莲(Linn Walp)的血糖反应。在糖尿病患者的管理中,除了膳食的血糖指数外,还应考虑血糖反应。
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引用次数: 1
COVID-19 pandemic in Nigeria: A case study of Kano State – Challenges and lessons learned 2019冠状病毒病大流行在尼日利亚:卡诺州的案例研究——挑战和经验教训
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2020-10-01 DOI: 10.4103/jcls.jcls_73_20
O. Odukoya, U. Omeje
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引用次数: 2
Base excess and pH as predictors of outcomes in secondary peritonitis in a resource limited setting - A prospective study 在资源有限的情况下,碱过量和pH值作为继发性腹膜炎预后的预测因素——一项前瞻性研究
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2020-10-01 DOI: 10.4103/jcls.jcls_18_20
O. Afuwape, O. Ayandipo, Samuel Aroso
Background: Estimation of the serum pH and base excess as determinants of the adequacy of resuscitation may predict the patient outcome in peritonitis. Materials, Patients and Methods: This was a prospective study conducted in University College Hospital, Ibadan, on patients from 18 years and above with diagnosis of secondary peritonitis who had exploratory laparotomy over a 4-month period (January to April 2017). The patients' biodata, pulse rate, blood pressure, and clinical diagnosis were documented. At presentation, the patients were resuscitated with intravenous normal saline and broad-spectrum antibiotics. Each patient had measurements of acid-base status, and pH analyzed at presentation and in the immediate postoperative period (within 1 h) using the I-STAT point of care device. They were followed up for 48 h after the surgery. The changes in base excess and serum pH in survivors and nonsurvivors were described at 48 h after surgery. This was statistically compared using SPSS version 20 (Chicago, IL, USA). Results: A total of 45 patients were recruited comprising 37 males and 8 female patients. The mean age was 40.86 ± 15.45 years. The mean admission base excess was −4.76 ± 5.41. The mean admission pH was 7.41 ± 0.07. There were 28 (62%) survivors and 17 (38%) mortalities. The pH on admission and base excess values and after surgery demonstrated statistical significance in survivors and nonsurvivors. Conclusion: Changes in base excess and serum pH values are plausible outcome markers in patients with peritonitis resuscitated with early goal-directed therapy.
背景:估计血清pH值和碱性过剩作为复苏充分性的决定因素,可以预测腹膜炎患者的预后。材料、患者和方法:这是一项在伊巴丹大学学院医院进行的前瞻性研究,研究对象为18岁及以上诊断为继发性腹膜炎的患者,他们在4个月的时间内(2017年1月至4月)进行了剖腹探查。记录患者的生物资料、脉搏率、血压和临床诊断。入院时,给予静脉生理盐水和广谱抗生素复苏。使用I-STAT护理点装置测量每位患者在就诊时和术后1小时内的酸碱状态和pH值。术后随访48小时。在手术后48小时描述幸存者和非幸存者的碱基过量和血清pH的变化。使用SPSS version 20 (Chicago, IL, USA)进行统计比较。结果:共纳入45例患者,其中男37例,女8例。平均年龄40.86±15.45岁。平均入院基准超额为- 4.76±5.41。平均入院pH为7.41±0.07。幸存者28例(62%),死亡17例(38%)。入院时和手术后的pH值在幸存者和非幸存者中具有统计学意义。结论:碱过量和血清pH值的变化可能是腹膜炎患者早期目标导向治疗复苏的预后指标。
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引用次数: 3
Relating oral hygiene, gingival, and periodontal status with nicotine dependence among smokers - A cross-sectional study 吸烟者的口腔卫生、牙龈和牙周状况与尼古丁依赖关系的横断面研究
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2020-10-01 DOI: 10.4103/jcls.jcls_35_19
Chibuzor Boi-Ukeme, C. Azodo
Background: The objective was to examine the oral hygiene, gingival, and periodontal status among smokers and to relate them with nicotine dependence. Methods: The cross-sectional study was carried out among smokers and nonsmokers in Benin-City, Edo State. Data collection was done through questionnaire and oral examination. The indices applied were Fagerstrom test, Simplified Oral Hygiene Index (OHI-S), Gingival Index (GI), Community Periodontal Index, and tooth mobility index. Results: A total of 40 (20 smokers and 20 nonsmokers) persons participated in the study. The mean OHI-S for smokers was 2.87 ± 0.92 while that of nonsmoker was 2.20 ± 0.73 and this was statistically significant (P = 0.015). The mean GI for smokers was 1.04 ± 0.36 while that of nonsmoker was 0.80 ± 0.22 and this was statistically significant (P = 0.018). The mean number of mobile teeth for smokers was 0.15 ± 0.49 while that of nonsmoker was. 00 ± 0.00 and this was not statistically significant (P = 0.178). One-quarter (25%) of smokers had score 3 and 4 while only 5% of nonsmokers had were found Shallow and deep pockets were found score 3 and 4. About half (45.0%) of the smokers had low-moderate nicotine dependency among the smokers revealed that. Participants with higher nicotine dependence had nonsignificantly poorer oral hygiene, gingival, and periodontal status than their counterparts. Conclusion: Smokers generally had poorer oral hygiene, gingival, and periodontal status as compared to the nonsmokers. Smokers with higher nicotine dependence did not have poorer oral hygiene, gingival, and periodontal status than their counterparts.
背景:目的是检查吸烟者的口腔卫生、牙龈和牙周状况,并将其与尼古丁依赖联系起来。方法:对江户州贝宁市的吸烟者和非吸烟者进行横断面研究。通过问卷调查和口头检查的方式收集资料。采用Fagerstrom试验、简化口腔卫生指数(OHI-S)、牙龈指数(GI)、社区牙周指数和牙齿活动性指数。结果:共有40人(20名吸烟者和20名非吸烟者)参与了这项研究。吸烟者的平均ohi为2.87±0.92,非吸烟者的平均ohi为2.20±0.73,差异有统计学意义(P = 0.015)。吸烟者的平均GI为1.04±0.36,非吸烟者的平均GI为0.80±0.22,差异有统计学意义(P = 0.018)。吸烟者的平均活动牙数为0.15±0.49颗,非吸烟者的平均活动牙数为0.15±0.49颗。00±0.00,差异无统计学意义(P = 0.178)。四分之一(25%)的吸烟者得分为3分和4分,而只有5%的非吸烟者的口袋分为3分和4分。吸烟者中约有一半(45.0%)为中低度尼古丁依赖。尼古丁依赖程度较高的受试者的口腔卫生、牙龈和牙周状况均不明显差于对照组。结论:与不吸烟者相比,吸烟者的口腔卫生、牙龈和牙周状况普遍较差。尼古丁依赖程度较高的吸烟者的口腔卫生、牙龈和牙周状况并不比其他吸烟者差。
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引用次数: 0
Return to work during the epidemic – Implications for surgical care: Caution is the word 疫情期间重返工作岗位——对外科护理的启示:谨慎为上
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2020-07-01 DOI: 10.4103/jcls.jcls_53_20
A. Ademuyiwa
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引用次数: 0
Experience with the management of pediatric laryngopharyngeal reflux in an Indian teaching hospital 印度一家教学医院小儿咽喉反流的治疗经验
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2020-07-01 DOI: 10.4103/jcls.jcls_38_19
S. Swain, Jasashree Choudhury
Aim: Laryngopharyngeal reflux (LPR) is the retrograde flow of gastric content to the larynx and pharynx where these materials come in contact to the upper aerodigestive tract. This clinical entity is less studied among the pediatric population. The objective of this study is to evaluate the impact of LPR in the pediatric population. Materials and Methods: This retrospective study was done in between December 2016 and January 2019. Clinical data such as associated symptoms, endoscopic findings, laboratory testing, therapeutic interventions, and outcome were analyzed. Endoscopic findings were considered to be consistent with LPR in the pediatric age included: Lingual tonsil hypertrophy, postglottic edema, true vocal fold edema and congested and swollen arytenoids, congested inter-arytenoids area. Results: There were 212 children evaluated for dysphonia. There were 38 girls (52.77) and 34 boys (47.22%), and mean age at presentation was 9.32 years with a male-to-female ratio of 0.89:1. Out of 212 children who underwent endoscopy, 72 had shown LPR disease. Five children (6.94%) showed vocal nodules, 3 (4.16%) showed vocal fold cyst, and 2 (2.77%) children showed subglottic edema along with LPR. All the children were treated with anti-reflux measures. By second follow-up visit on 1 month, 68 children (94.44%) had improved symptomatically. Conclusion: LPR appears to cause laryngeal manifestations more commonly in children. In this study, all the children were presenting dysphonia, intermittent cough, foreign-body sensation in throat, and throat-clearing habit. All of them showing congested arytenoids and inter-arytenoid membrane. Early diagnosis and treatment often result in the improvement of hoarseness of voice and prevent complications. LPR in the pediatric population is almost a new diagnosis.
目的:喉咽反流(LPR)是胃内容物逆行流到喉部和咽部,在那里这些物质与上气消化道接触。这一临床实体在儿科人群中研究较少。本研究的目的是评估LPR对儿科人群的影响。材料和方法:本回顾性研究于2016年12月至2019年1月期间完成。分析了相关症状、内窥镜检查结果、实验室检查、治疗干预和结果等临床数据。内窥镜检查结果与LPR一致,包括:舌扁桃体肥大,声门后水肿,真声带水肿,类鼻窦充血肿胀,类鼻窦间充血。结果:有212名儿童被评估为语音障碍。其中女生38例(52.77),男生34例(47.22%),平均发病年龄9.32岁,男女比0.89:1。在接受内窥镜检查的212名儿童中,72名显示LPR疾病。声带小结5例(6.94%),声带囊肿3例(4.16%),声门下水肿2例(2.77%)。所有患儿均接受抗反流措施治疗。第二次随访1个月,68例患儿(94.44%)症状改善。结论:LPR在儿童中更为常见。在本研究中,所有患儿均表现为发音困难、间歇性咳嗽、咽喉异物感和清喉习惯。均表现为类蝶体及类蝶间膜充血。早期诊断和治疗往往能改善声音嘶哑,防止并发症的发生。LPR在儿科人群中几乎是一种新的诊断。
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引用次数: 4
Diuretic resistance in patients with heart failure: Clinical characteristics and predictors of outcome 心力衰竭患者的利尿剂抵抗:临床特征和预后预测因素
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2020-07-01 DOI: 10.4103/jcls.jcls_1_20
Mesfin Tasew, T. Aklilu, S. Abdissa
Background: Our aim was to study the clinical characteristics and predictors of mortality in heart failure (HF) with diuretic resistance. Methods: We conducted a 5-year retrospective study on 119 HF patients with diuretic resistance at Tikur Anbessa Specialized Teaching Hospital. The primary endpoint was mortality. We compared baseline characteristics and assessed association in patients who received high-dose (≥120 mg) versus low-dose (<120 mg) furosemide. Bivariate and multivariate logistic regression analyses were done. Results: Patients receiving high-dose diuretic had significantly higher mean values for age and in New York Heart Association Class IV HF and received a larger dose of hydrochlorothiazide than low-dose patients. They also had significantly higher mean values for systolic blood pressure (SBP), hemoglobin, and serum creatinine. There was no significant difference in mortality between the two groups. On multivariate analysis, association with the high-dose diuretic group remained significant for the higher mean value for SBP and serum creatinine. Independent predictors of mortality were anemia (adjusted odds ratio [AOR]: 4.1, 95% confidence interval [CI]: 1.1–15.2, P = 0.04), infective endocarditis (AOR: 4.9, 95% CI: 2.1–25.7, P = 0.01), and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) (AOR: 3.1, 95% CI: 1.1–9.9, P = 0.04). The use of digoxin was associated with lower mortality (AOR: 0.21, 95% CI: 0.06–0.78, P = 0.01). Conclusions: In HF patients with diuretic resistance, anemia, infective endocarditis, and the use of NSAIDs were independently associated with increased mortality, whereas the use of digoxin was associated with reduced mortality. Early identification and treatment of the risk factors could play a role in reducing mortality.
背景:我们的目的是研究伴有利尿剂抵抗的心力衰竭(HF)的临床特征和死亡率预测因素。方法:对在提库尔安贝萨专科教学医院就诊的119例心衰利尿剂耐药患者进行5年回顾性研究。主要终点是死亡率。我们比较了高剂量(≥120mg)和低剂量(< 120mg)呋塞米患者的基线特征和相关性。进行了双变量和多变量logistic回归分析。结果:接受高剂量利尿剂治疗的患者年龄和纽约心脏协会IV级HF的平均值明显高于接受低剂量氢氯噻嗪治疗的患者。他们的收缩压(SBP)、血红蛋白和血清肌酐的平均值也明显较高。两组患者的死亡率无显著差异。在多变量分析中,与高剂量利尿剂组相关的收缩压和血清肌酐的平均值较高。死亡率的独立预测因素为贫血(校正优势比[AOR]: 4.1, 95%可信区间[CI]: 1.1-15.2, P = 0.04)、感染性心内膜炎(AOR: 4.9, 95% CI: 2.1-25.7, P = 0.01)和使用非甾体类抗炎药(AOR: 3.1, 95% CI: 1.1-9.9, P = 0.04)。地高辛的使用与较低的死亡率相关(AOR: 0.21, 95% CI: 0.06-0.78, P = 0.01)。结论:伴有利尿剂抵抗、贫血、感染性心内膜炎和使用非甾体抗炎药的心衰患者与死亡率增加独立相关,而地高辛的使用与死亡率降低相关。早期发现和治疗危险因素可以在降低死亡率方面发挥作用。
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引用次数: 0
Neoplasms of the appendix: An experience of a tertiary hospital in Southwestern Nigeria 阑尾肿瘤:尼日利亚西南部一家三级医院的经验
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2020-07-01 DOI: 10.4103/jcls.jcls_19_20
M. Ajani, S. Omenai, O. Iyapo
Background: The appendix is a vestigial tube-like organ. Its exact physiological function is unknown. Appendectomies are done usually following a clinical diagnosis of acute appendicitis. Neoplasms can arise from this organ as well. Carcinoids are the most common neoplasms arising commonly at the tips. This retrospective review of neoplasms of the appendix was aimed at identifying the incidence and describing the histological variants of neoplasms of the appendix in our environment. Materials and Methods: This study was a 10-year retrospective review of all appendectomy specimens submitted to the Department of Pathology, University College Hospital, Ibadan, Nigeria, from January 1, 2009, to December 31, 2018. Microscopy was done examining the longitudinal sections from the tip to the base of the appendix. The histological diagnosis was extracted from the records in the department and classified using the WHO classification of tumors of the appendix (2019). Patients' biodata such as age and sex were also extracted. The data were analyzed for frequency distribution using SPSS 23. Results: The incidence of neoplasms in the appendix was 0.84% of the 1071 appendectomies received in our department over the study period. Low-grade appendiceal mucinous neoplasm (LAMN) was the most common histological variant accounting for 55.5% of neoplasms, followed by metastatic carcinoma at 22.2% and carcinoids at 11.1%. There was a female preponderance of 77.8%. Conclusion: Neoplasms of the appendix are rare in our environment, and LAMN was the most common neoplasm of the appendix in our institution. There is a female preponderance among patients with appendiceal neoplasms.
背景:阑尾是一个退化的管状器官。其确切的生理功能尚不清楚。阑尾切除术通常在临床诊断为急性阑尾炎后进行。肿瘤也可以从这个器官产生。类癌是最常见的肿瘤,常见于鼻尖。本回顾性回顾阑尾肿瘤的目的是确定发病率和描述阑尾肿瘤的组织学变异在我们的环境。材料和方法:本研究对2009年1月1日至2018年12月31日期间提交给尼日利亚伊巴丹大学学院医院病理科的所有阑尾切除术标本进行了为期10年的回顾性分析。显微镜检查从阑尾尖端到底部的纵剖面。从科室病历中提取组织学诊断,采用WHO《阑尾肿瘤分类(2019)》进行分类。同时提取患者的年龄、性别等生物数据。使用SPSS 23对数据进行频率分布分析。结果:在我科1071例阑尾切除术中,阑尾肿瘤的发生率为0.84%。低级别阑尾粘液瘤(LAMN)是最常见的组织学变异,占肿瘤的55.5%,其次是转移癌(22.2%)和类癌(11.1%)。其中女性占77.8%。结论:阑尾肿瘤在本院少见,LAMN是本院最常见的阑尾肿瘤。阑尾肿瘤患者以女性居多。
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引用次数: 1
Clinical and microbiological profile of enteric fever among pediatric patients in a tertiary care center in South India: A cross-sectional study 临床和肠道发热的儿科患者在三级护理中心在印度南部:一个横断面研究
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2020-07-01 DOI: 10.4103/jcls.jcls_17_20
A. Malini, C. Barathy, N. Madhusudan, C. Johnson
Introduction: Enteric fever, which is endemic in India, is a significant cause for morbidity, particularly among young children. Enteric fever is associated with high fever, abdominal pain, diarrhea, and splenomegaly. Recently, there have been increasing reports of enteric fever due to Salmonella enterica serovar Paratyphi A and multidrug resistance among Salmonella species. Objectives: The objective of this study was to know the relative occurrence of Salmonella Typhi and Salmonella Paratyphi A from blood cultures of enteric fever cases, to study the sensitivity pattern of Salmonella species isolated, to compare the clinical profiles in typhoid and paratyphoid fever, and to know their treatment outcome. Materials and Methods: It was a prospective hospital-based cross-sectional study. The demographic, clinical, and laboratory data were recorded for all cases included in the study. All clinically suspected cases of enteric fever were confirmed by blood culture and/or the Widal test. Antibiotic sensitivity was tested by the Kirby–Bauer disc diffusion method. Results were analyzed using SPSS version 21. Results: One hundred and nineteen cases were confirmed enteric fever. Their clinical profile is discussed. Out of 119 cases, 24 showed blood culture positivity. Salmonella Paratyphi A and Salmonella Typhi were isolated in the ratio of 3:1. The isolates were sensitive to ampicillin, co-trimoxazole, ceftriaxone, and azithromycin. Ceftriaxone was the most commonly used antibiotic for treatment. All patients recovered, and no mortality was encountered. Complications were seen in 33 children (27.7%), which included subclinical hepatitis, bronchitis, and pneumonia. Conclusion: Considering the blood culture results, enteric fever due to S. Paratyphi A was more common in our study. Multidrug resistance was not seen among Salmonella species. The duration of illness and complications were more with typhoid than paratyphoid cases.
导言:肠热病是印度的一种地方病,是发病的重要原因,特别是在幼儿中。肠热伴有高热、腹痛、腹泻和脾肿大。最近,有越来越多的报告,由于肠炎沙门氏菌血清型副伤寒和多种沙门氏菌耐药引起的肠热。目的:了解伤寒和副伤寒沙门氏菌在肠热患者血培养中的相对发生率,研究分离沙门氏菌的敏感性,比较伤寒和副伤寒的临床特点,了解其治疗效果。材料和方法:这是一项前瞻性的以医院为基础的横断面研究。记录研究中所有病例的人口学、临床和实验室数据。所有临床疑似肠热病例均经血培养和/或维达尔试验证实。采用Kirby-Bauer圆盘扩散法检测抗生素敏感性。使用SPSS version 21对结果进行分析。结果:确诊肠热119例。讨论了他们的临床表现。119例中,24例血培养阳性。甲型副伤寒沙门菌和伤寒沙门菌的分离比例为3:1。该菌株对氨苄西林、复方新诺明、头孢曲松和阿奇霉素敏感。头孢曲松是最常用的抗生素。所有患者均康复,无死亡病例。并发症33例(27.7%),包括亚临床肝炎、支气管炎和肺炎。结论:从血培养结果来看,副伤寒沙门氏菌引起的肠热在本研究中更为常见。沙门氏菌未见多药耐药。伤寒病例的病程和并发症多于副伤寒病例。
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引用次数: 2
An interesting story of intravascular hemolysis but normal haptoglobin and bilirubin levels 一个有趣的故事,血管内溶血,但正常的血红蛋白和胆红素水平
IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2020-07-01 DOI: 10.4103/jcls.jcls_76_19
Kriti Chauhan, N. Shandilya
Multiple bee stings are associated with intravascular hemolysis (IVH), rhabdomyolysis, hypotension, renal tubule injury, and all causing acute kidney injury. Evidence in support of hemolysis includes anemia, hyperbilirubinemia, hemoglobinemia, hemoglobinuria, low haptoglobin (Hp) levels, elevated lactate dehydrogenase, and Coomb's test (if antibody mediated). However, under certain circumstances, hemoglobinemia and hemoglobinuria may be the only evidence of IVH depending on the etiological factors in association with the environment inside the body. Bee venom is known to have deleterious actions on different tissue types (neurotoxin, muscle paralytic, hematotoxic, epithelial damage, etc.). Altogether, they determine the outcome and presentation. Apart from this, there are several conditions that determine the binding of oxygen and Hp to hemoglobin (Hb). Arterial blood gases (ABGs) play a very important role in this. Hence, it is important for the pathologists to have an understanding of ABG as well to know how even simple tests (Hb, bilirubin, and Hp) can get affected by them. We describe one such occurrence in a patient with multiple hornet bee stings and formulate the likely causes and pathogenesis.
多次蜜蜂蜇伤与血管内溶血(IVH)、横纹肌溶解、低血压、肾小管损伤有关,均可引起急性肾损伤。支持溶血的证据包括贫血、高胆红素血症、血红蛋白血症、血红蛋白尿、低接触珠蛋白(Hp)水平、乳酸脱氢酶升高和Coomb试验(如果抗体介导)。然而,在某些情况下,血红蛋白血症和血红蛋白尿可能是IVH的唯一证据,这取决于与体内环境相关的病因因素。已知蜂毒对不同类型的组织(神经毒素,肌肉麻痹,血液毒性,上皮损伤等)具有有害作用。总之,他们决定了结果和呈现。除此之外,还有几个条件决定氧和Hp与血红蛋白(Hb)的结合。动脉血气(ABGs)在其中起着非常重要的作用。因此,对于病理学家来说,了解ABG以及了解即使是简单的测试(Hb、胆红素和Hp)如何受到它们的影响是很重要的。我们描述一个这样的发生在一个病人与多个大黄蜂蜇伤和制定可能的原因和发病机制。
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引用次数: 1
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Journal of Clinical Sciences
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