Journal of dentistry最新文献

{"title":"Implant-supported full-arch fixed dental prostheses manufactured through a direct digital workflow using a calibrated splinting framework: A retrospective clinical study","authors":"Filippo Rustichini ,&nbsp;Roldano Romolini ,&nbsp;Maria Chiara Salmi ,&nbsp;Leonardo Gennai ,&nbsp;Francesco Vermigli ,&nbsp;Francesco Guido Mangano","doi":"10.1016/j.jdent.2025.105605","DOIUrl":"10.1016/j.jdent.2025.105605","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the clinical precision, one-year survival, and complications of implant-supported full-arch fixed dental prostheses (ISFAFDPs) manufactured through a full-digital protocol, which involved intraoral scanning of the edentulous arch with a calibrated splinting framework (CSF; RingFix®; IOSFix Dental, Madrid, Spain) and computer-aided design and manufacturing of monolithic zirconia restorations.</div></div><div><h3>Methods</h3><div>This retrospective clinical study involved 37 patients (21 males and 16 females) aged 48–87 years (mean age: 68.8 ± 9.7 years) who had been restored with 45 ISFAFDPs manufactured using a full-digital protocol. The primary outcomes were the clinical precision of the ISFAFDPs and their survival and the incidence of complications at the one-year follow-up. The correction of errors in the position of the implants generated by the intraoral scan was computed using the CSF. The data were statistically analyzed.</div></div><div><h3>Results</h3><div>At delivery, all ISFAFDPs were clinically precise, showing ideal passive fit on the implants, confirmed clinically and radiographically. No implants had been lost at the one-year follow-up. The incidence of prosthetic complications (4.4 %) was relatively low; one prosthesis broke, giving a restoration survival rate of 97.8 %.</div></div><div><h3>Conclusions</h3><div>Within the limits of this study, monolithic zirconia ISFAFDPs manufactured through intraoral scanning of the edentulous arches with a CSF were clinically precise, presenting a low incidence of complications at one year.</div></div><div><h3>Clinical relevance</h3><div>Using the CSF can improve the accuracy of digital full-arch implant scans, allowing the manufacture of clinically precise ISFAFDPs.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"154 ","pages":"Article 105605"},"PeriodicalIF":4.8,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing dental education with a 3D point cloud comparison and augmented reality for auto-evaluation of fixed prosthodontic practice: An in vitro study","authors":"Hang-Nga Mai ,&nbsp;Yong-Gun Kim ,&nbsp;Seok-Hwan Cho ,&nbsp;Tim Joda ,&nbsp;Du-Hyeong Lee","doi":"10.1016/j.jdent.2024.105493","DOIUrl":"10.1016/j.jdent.2024.105493","url":null,"abstract":"<div><h3>Objectives</h3><div>Traditional fixed prosthodontic training evaluations are time-consuming and subjective. This study aimed to introduce and evaluate a novel 3D auto-evaluate tooth preparation with an augmented reality (3DAR) visualization algorithm to enhance dental education for students and improve the efficiency of fixed prosthodontic training evaluations.</div></div><div><h3>Methods</h3><div>Fifty maxillary central incisors and first molars prepared by 50 dental students on typodont models were scanned with a 3D scanner to capture STL files and evaluated using the 3DAR algorithm, which calculated Euclidean distances and root mean square error (RMSE) for accuracy assessment and assigned scores based on RMSE, using an augmented reality (AR) app for interactive evaluation and visualization. These scores were compared to manual scoring with computer assistance (MSCA method), which also used RMSE but required manual alignment and model scoring. Intrarater and interrater reliability of the 3DAR scoring method was assessed using intraclass correlation coefficients (ICC) and compared with the MSCA method. Additionally, the feasibility of 3DAR was evaluated based on evaluation time and user satisfaction.</div></div><div><h3>Results</h3><div>The 3DAR method demonstrated good-to-excellent interrater agreement (ICC = 0.75–0.95) and perfect intrarater reliability (ICC = 1), while the MSCA method showed moderate-to-good reliability (ICC = 0.74–0.89). 3DAR significantly reduced evaluation time (10.514 s vs. 2 h required for MSCA) and received high user satisfaction ratings (average score = 4.66±0.24).</div></div><div><h3>Conclusions</h3><div>The 3DAR algorithm offers a reliable and efficient assessment method for prosthodontic training. It showed strong agreement with traditional methods, significantly reduced evaluation time, and achieved high user satisfaction.</div></div><div><h3>Clinical significance</h3><div>The integration of a 3D augmented reality-based auto-evaluation algorithm into tooth preparation training enhances reliability and provides interactive, real-time feedback on performance, highlighting its potential to advance dental education practices.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105493"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of an AI-driven tool to evaluate chewing function: a proof of concept","authors":"Anastasios Grigoriadis ,&nbsp;Soroush Baseri Saadi ,&nbsp;Linda Munirji ,&nbsp;Reinhilde Jacobs","doi":"10.1016/j.jdent.2024.105525","DOIUrl":"10.1016/j.jdent.2024.105525","url":null,"abstract":"<div><h3>Background</h3><div>Masticatory function is an important determinant of oral health and a contributing factor in the maintenance of general health. Currently, objective assessment of chewing function is a clinical challenge. Previously, several methods have been developed and proposed, but implementing these methods in clinics may not be feasible. Therefore, more efforts are needed for accurate assessment of chewing function and clinical use.</div></div><div><h3>Aim</h3><div>The study aimed to establish a proof of concept for development and validation of an automated tool for evaluating masticatory function.</div></div><div><h3>Methods</h3><div>YOLOv8, a deep neural network, was fine-tuned and trained to detect and segment food fragments. The model's performance was assessed using bounding box recall metrics, segmentation metrics, confusion matrix, and sensitivity values. Additionally, a separate conversion test set evaluated the model's segmentation performance using physical units, demonstrated with Bland-Altman diagrams.</div></div><div><h3>Results</h3><div>The YOLOv8-model achieved recall and sensitivity rates exceeding 90 %, effectively detecting and classifying food fragments. Out of 316 ground truth fragments, 301 were correctly classified, with 15 missed and 5 false positives. The Bland-Altman diagram indicated general agreement but suggested a systematic overestimation in measuring the size of post-masticated food fragments.</div></div><div><h3>Conclusion</h3><div>Artificial intelligence presents a reliable approach for automated analysis of masticatory performance. The developed application proves to be a valuable tool for future clinical assessment of masticatory function.</div></div><div><h3>Clinical significance</h3><div>The current study provides a proof of concept for development of an automated tool for clinical assessment of masticatory function.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105525"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3-Dimensional quantitative analysis of mandibular motion in TMD and healthy subjects: Comparison with clinical observations","authors":"Wen Tang ,&nbsp;Yue Wu ,&nbsp;Jiajun Ma ,&nbsp;Peter Svensson ,&nbsp;Kelun Wang ,&nbsp;Hengjia Zhang ,&nbsp;Lizhe Xie ,&nbsp;Bin Yan","doi":"10.1016/j.jdent.2024.105534","DOIUrl":"10.1016/j.jdent.2024.105534","url":null,"abstract":"<div><h3>Objectives</h3><div>To establish a quantitative method for objectively assessing 3-dimensional (3D) mandibular trajectories and comparing clinical evaluations with computational analyses.</div></div><div><h3>Methods</h3><div>In total, 184 volunteers were recruited and grouped into control (<em>n</em> = 121) and temporomandibular disorder (TMD) groups (<em>n</em> = 63) according to the dual-axis DC/TMD checklist. 3D trajectories were generated by integrating mandibular motion and cone beam computed tomography (CBCT) records. Via digitalized data processing, the following 3 outcomes were assessed: (1) smoothness using the best-fitting polynomial curve, (2) open-closure separation by measuring the deviation between open-closure phases, and (3) condylar trajectory symmetry by comparing left and right movements. Intraclass Correlation Coefficients (ICC) were used to determine agreement between expert observations and quantitative results. Reference ranges for each parameter from the normal population were calculated. Mann‒Whitney test was used to analyze the features of the trajectories between the two groups.</div></div><div><h3>Results</h3><div>ICC confirmed strong consistency between the parametric variations and expert observations (smoothness: 0.797; open-closure separation: 0.820; left-right symmetry: 0.920). Quantitative analyses revealed significant differences (<em>P</em> &lt; 0.043 for smoothness, <em>P</em> &lt; 0.01 for separation, and <em>P</em> = 0.012 for symmetry) in all comparisons between movement trajectories of normal participants and those with TMD, with the latter group exhibiting greater variation and irregularities. The normal range of smoothness was calculated for condylar trajectories between 0 and 0.25 and 0–0.10 for incisal point trajectories. Open-closure separation normal range was computed between 0 and 2.28 mm for incisal point trajectory, 0–1.90 mm for left condylar trajectory, and 0–1.76 mm for right condylar trajectory. The normal range of symmetry between condylar trajectories was calculated to be between 0 and 4.21 mm.</div></div><div><h3>Conclusions</h3><div>This quantitative analysis was confirmed to be reliable and consistent with expert observations. This allowed for the discovery of substantially quantified differences in smoothness, open-closure separation, and symmetry of the motion trajectories in TMD patients versus controls.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105534"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of fit and trueness of single-unit and short-span fixed dental restorations fabricated by additive and subtractive manufacturing—A systematic review and meta-analysis","authors":"Anna Németh ,&nbsp;Viktória Vitai ,&nbsp;Kata Kelemen ,&nbsp;Brigitta Teutsch ,&nbsp;Bence Szabó ,&nbsp;Gábor Gerber ,&nbsp;Gábor Varga ,&nbsp;Réka Fazekas ,&nbsp;Péter Hegyi ,&nbsp;Judit Borbély","doi":"10.1016/j.jdent.2024.105527","DOIUrl":"10.1016/j.jdent.2024.105527","url":null,"abstract":"<div><h3>Objectives</h3><div>Numerous studies have been conducted on the adaptation of dental restorations fabricated by additive (AM) and subtractive manufacturing (SM); however, the results are conflicting. This systematic review and meta-analysis aimed to evaluate the fit and trueness of fixed restorations made by AM compared to SM.</div></div><div><h3>Data</h3><div>Studies investigating internal fit, marginal fit, and trueness of fixed prostheses were involved.</div></div><div><h3>Sources</h3><div>The protocol was registered in PROSPERO (registration number CRD42022323090). An electronic search was performed with a predefined search query across four medical databases on the 6th of September 2023.</div></div><div><h3>Study selection</h3><div>A total of 57 eligible studies were included and sub-grouped by material type (metals, ceramics, acrylic resins, composites). The outcomes were specified as internal fit, marginal fit, and trueness expressed in micrometer (µm). Further subgrouping was based on measurement area: axial, occlusal, and marginal. When we analyzed marginal fit, there were no statistically significant differences between the two techniques in any of the subgroups. The measurement of internal fit metal and ceramic restorations provided no significant differences. However, milled acrylic resin restorations showed a significantly higher occlusal gap compared to 3D printed prostheses with 39.12 µm (95 % CI: 12.44; 65.79). In the case of trueness, a statistically significant difference was observed between ceramic AM and SM restorations with −47.76 µm (95 % CI: −95.51; −0.00). QUIN and GRADE Pro tools were used to evaluate the risk of bias and certainty of evidence.</div></div><div><h3>Conclusion</h3><div>Fixed restorations manufactured with additive manufacturing are valid alternatives to subtractive manufacturing in the digital workflow.</div></div><div><h3>Clinical significance</h3><div>Additive manufacturing is an accurate and cost-effective manufacturing method of digital workflow, especially for metal and resin fixed restorations. Once the challenges in ceramics manufacturing are addressed, AM will show more significant promise in the field.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105527"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of automated face coding (AFC) in older adults: A pilot study","authors":"Elena Mshael ,&nbsp;Angela Stillhart ,&nbsp;Claudio Rodrigues Leles ,&nbsp;Murali Srinivasan","doi":"10.1016/j.jdent.2025.105555","DOIUrl":"10.1016/j.jdent.2025.105555","url":null,"abstract":"<div><h3>Objectives</h3><div>The study aimed to assess the prevalence and nature of emotional expressions in care-dependent older adults, using an automated face coding (AFC) software. By examining the seven fundamental emotions, the study sought to understand how these emotions manifest and their potential implications for dental care in this population.</div></div><div><h3>Methods</h3><div>Fifty care-dependent older adults’ (mean-age: 78.90 ± 10.83 years; n = 50, men = 25, women = 25) emotional expressions were analyzed using an AFC software. The study measured the prevalence of the seven fundamental emotions including neutral, happy, sad, angry, surprised, scared, and disgusted. Correlations were explored between these expressions and demographic variables such as sex, age, Mini-Mental State Examination (MMSE) scores, as well as the use of sedation. Descriptive statistics, non-parametric tests and Spearman's rho correlations were applied for statistical analysis (p &lt; 0.05).</div></div><div><h3>Results</h3><div>Neutral expression was the most common emotion (0.732 ± 0.23), with other emotions largely inactive. A trace of happiness was detected in women (0.110 ± 0.23), though not statistically significant (p = 0.061). Significant correlations were found between happy expressions and left eye opening (p = 0.021), and a negative correlation was observed between mouth opening and sad expressions (p = 0.049). No significant associations were found with age, MMSE scores, or sedation use.</div></div><div><h3>Conclusions</h3><div>This study found that AFC software can detect and quantify emotions from facial expressions of dependent older adults and that they predominantly exhibited neutral expressions, with few signs of other emotions. Future research should explore these influences to inform personalized care approaches.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105555"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The microbial co-infection interaction network in apical periodontitis with sinus tracts","authors":"Wenying Wang ,&nbsp;Yang Qu ,&nbsp;Hui Chen ,&nbsp;Lijia Huang ,&nbsp;Lisha Gu","doi":"10.1016/j.jdent.2024.105496","DOIUrl":"10.1016/j.jdent.2024.105496","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to characterize the bacterial co-occurrence features and potential interactions associated with the presence of sinus tracts in apical periodontitis in a Chinese population by using 16S rRNA next-generation sequencing (NGS).</div></div><div><h3>Methods</h3><div>Thirty-one samples from twenty-six patients were collected from root canals. Following the extraction of the bacterial DNA, the V3–V4 hypervariable regions of the 16S rRNA gene were sequenced. Compositional diversity, prominent taxa and co-occurrence network analysis were compared according to the presence or absence of sinus tracts.</div></div><div><h3>Results</h3><div>The overall microbiota in two groups exhibited distinguished patterns. <em>Actinomyces</em> dominated in samples with sinus tracts while <em>Prevotella</em> was the most abundant in samples without sinus tracts. The major pathogens in sinus tracts exhibited a complex co-occurrence network, in which <em>Pseudomonas</em> formed a distinctive cluster with enriched abundance, and the extensive correlations centered on <em>Desulfovibrio</em> and <em>Pseudoramibacter</em> may suggest novel dependencies. In the network without sinus tracts, the <em>Bacteroidetes</em> and <em>Firmicutes</em> taxa presented close internal associations.</div></div><div><h3>Conclusions</h3><div>The sequencing results confirmed the complexity of the microbiota in AP. The presence of sinus tracts was associated with distinctive infective patterns and complicated microbial co-infection interaction networks. Further investigations should be adopted to elucidate the relationship between the novel interactions and disease progression.</div></div><div><h3>Clinical significance</h3><div>Exploring the microbial interactions leads to a better understanding of etiology of apical periodontitis. Utilizing next generation sequencing techniques, our research uncovered the bacterial community structure and observed co-infection networks associated with sinus tracts, providing potential insights for prognosis prediction and targeted therapeutics of persistent inflammation.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105496"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring ageism and elderly care in dentistry: A comprehensive scoping review","authors":"Elis Ribeiro Mariucio Aranha ,&nbsp;Daniele Fernanda Felipe ,&nbsp;Lucas França Garcia","doi":"10.1016/j.jdent.2024.105524","DOIUrl":"10.1016/j.jdent.2024.105524","url":null,"abstract":"<div><h3>Objectives</h3><div>This scoping review aims to investigate the perceptions of dental professionals regarding aging and geriatric dentistry, as well as to identify studies focused on ageism in dental care.</div></div><div><h3>Data</h3><div>The review followed guidelines from the Joanna Briggs Institute and PRISMA-ScR. A systematic search was conducted in the databases, covering the period from 2019 to 2024.</div></div><div><h3>Sources</h3><div>PubMed, Scopus, and Web of Science were searched.</div></div><div><h3>Study selection</h3><div>Articles focusing on ageism or oral health in the elderly were included, while those with methodological flaws, duplicates, or unrelated content were excluded.</div></div><div><h3>Conclusions</h3><div>A total of 28 articles were included in the final analysis. The results reveal significant cultural differences in how ageism impacts dental care, with many dental professionals unprepared to treat elderly patients with physical and cognitive limitations. Geriatric dentistry remains underrepresented in dental curricula in some countries, leading to a shortage of specialized professionals. This review underscores the need for further research on the perspectives of practicing dentists and elderly patients to improve care and address the barriers caused by ageism.</div></div><div><h3>Clinical significance</h3><div>The review emphasizes the critical need to address ageism in dental care to enhance the quality of treatment for elderly patients. Effective strategies to counteract age-related biases can lead to improved clinical outcomes and more equitable care for all age groups.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105524"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of silver-copper co-loaded mesoporous bioactive glass as an advanced pulp-capping material","authors":"Jung-Chang Kung ,&nbsp;Hui-Ci Yang ,&nbsp;Tsung-Ying Yang ,&nbsp;Chi-Jen Shih","doi":"10.1016/j.jdent.2024.105549","DOIUrl":"10.1016/j.jdent.2024.105549","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the multifunctionality of silver-copper co-loaded mesoporous bioactive glass (MBG), with the goal of developing an advanced pulp-capping material.</div></div><div><h3>Methods</h3><div>The synthesis of materials was conducted using the sol-gel method, following the approach described in previous studies but with some modifications. The composition included 80 mol% SiO₂, 15 mol% CaO, and 5 mol% P₂O₅, with additional components of 5 mol% silver, 5 mol% copper, or 1 mol% silver combined with 4 mol% copper, designated as Ag5/80S, Cu5/80S, or Ag1Cu4/80S, respectively. Furthermore, crystal phases, surface morphology, and ion-releasing activity were analyzed using X-ray diffraction (XRD), transmission electron microscopy (TEM), and inductively coupled plasma mass spectrometry (ICP-MS), respectively. Human umbilical vein endothelial cells (HUVECs) were employed to assess wound-healing effects, while human dental pulp stem cells (hDPSCs) were utilized to evaluate osteogenic effects.</div></div><div><h3>Results</h3><div>Textural analyses indicated that Ag1Cu4/80S was successfully synthesized using modified procedures, demonstrating comparable ion co-releasing activity. Ag1Cu4/80S exhibited low toxicity and high cell proliferation rates, with a migration rate of 46 %, significantly higher than the &lt;10 % observed in other groups. In terms of osteogenesis, hDPSCs treated with Ag1Cu4/80S displayed enhanced alkaline phosphatase activity, with mineralization levels 1.6-fold greater than those of untreated controls.</div></div><div><h3>Conclusion</h3><div>The synthesis of Ag1Cu4/80S was successfully optimized. This material demonstrated significant wound-healing and comparable osteogenic effects relative to other tested materials, highlighting its potential for dental applications.</div></div><div><h3>Clinical Relevance</h3><div>Ag₁Cu₄/80S demonstrated a comparable effect on osteogenesis, indicating its potential to promote mineralization and suggesting its applicability in dental treatments.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105549"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended reality technology for alleviating adult dental anxiety: A systematic review and meta-analysis of randomized controlled trials","authors":"Zeng Yang ,&nbsp;Ping Liu ,&nbsp;Yu Luo ,&nbsp;Zhaowu Chai ,&nbsp;Bing Yang","doi":"10.1016/j.jdent.2024.105544","DOIUrl":"10.1016/j.jdent.2024.105544","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the effectiveness of extended reality (XR) technology in reducing dental anxiety in adults, through a systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>Comprehensive electronic and manual searches were conducted to identify randomized controlled trials published up to November 23, 2024, with no restrictions on publication year or language. Key outcomes included changes in anxiety and pain levels and cardiovascular indicators, such as blood pressure, heart rate, and oxygen saturation (SpO2). A random-effects model was used to evaluate the combined effects, with subgroup analyses exploring potential influencing factors. The updated Cochrane Risk of Bias 2 tool was used to assess the risk of bias. Meta-analysis was performed using RevMan 5.4.</div></div><div><h3>Results</h3><div>Of 1,207 screened records, 52 were retrieved for full-text evaluation, resulting in 10 studies meeting the inclusion criteria. The meta-analysis revealed that XR technology significantly reduced anxiety (mean difference [MD]:3.22, 95 % confidence interval [CI]:3.83 to -2.61; I² = 85 %), pain (MD:1.30, 95 % CI:2.07 to -0.53; I² = 84 %), and blood pressure scores (MD:3.34, 95 % CI:4.76 to -1.92; I² = 2 %). For cardiovascular indicators (heart rate, pulse, and SpO₂), the overall effect size was -3.83 (95 % CI:5.54 to -2.13; I² = 83 %).</div></div><div><h3>Conclusions</h3><div>Our findings suggest that XR technology effectively alleviates dental anxiety in adults. However, larger, rigorously designed trials to better understand its impact.</div></div><div><h3>Clinical significance</h3><div>XR technology reduces patients’ blood pressure, heart rate, pain, and anxiety during dental treatments. Rigorous, large-scale trials are needed to confirm its clinical effectiveness.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105544"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}