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Genetic and structural alterations of enamel and dentin- amelogenesis imperfecta, dentinogenesis imperfecta and dentin dysplasia 牙釉质和牙本质的遗传和结构改变——无釉质发育不全、牙本质发育不全和牙本质发育不良
Pub Date : 2019-08-28 DOI: 10.15406/jdhodt.2019.10.00494
M. Goldberg
The protein gene family includes extracellular molecules (ECM) proteins, responsible for dentin/bone coding (DSPP, DMP1, IBSP, MEPE, and SPP1), enamel (AMEL, ENAM, AMBN, and AMTN), as well as milk casein, and some salivary protein genes (Table 1). These molecules encompass inherited defects of dental enamel (AI) and dentin (DI and DD). They display both clinical and genetic heterogeneity. These groups include different sub-types recognized on the basis of their clinical appearance. Diseases affecting tooth structures have been classified into distinct tissues [enamel (AI) versus dentin (DI & DD), the specificity of the mutation (syndromic versus non-syndromic), and their pattern of inheritance [autosomal dominant (AD), autosomal recessive (AR), or X-linked recessive (XLR)]. Mutations in the AMELX , ENAM , MMP20 and KLK4 genes are associated with specific AI types. Another series of gene mutations influence dentin structure and composition [dentinogenesis imperfecta (DI) and dentin dysplasia (DD)]. These mutated genes are implicated in defective dental tissues.1–3
蛋白质基因家族包括细胞外分子(ECM)蛋白,负责牙本质/骨编码(DSPP, DMP1, IBSP, MEPE和SPP1),牙釉质(AMEL, ENAM, AMBN和AMTN),以及牛奶酪蛋白和一些唾液蛋白基因(表1)。这些分子包括牙釉质(AI)和牙本质(DI和DD)的遗传性缺陷。他们表现出临床和遗传异质性。这些组包括根据其临床表现识别的不同亚型。影响牙齿结构的疾病被分类为不同的组织[牙釉质(AI)与牙本质(DI & DD)],突变的特异性(综合征型与非综合征型),以及它们的遗传模式[常染色体显性(AD),常染色体隐性(AR)或x连锁隐性(XLR)]。AMELX、ENAM、MMP20和KLK4基因的突变与特定的AI类型相关。另一系列基因突变影响牙本质的结构和组成[牙本质发育不全(DI)和牙本质发育不良(DD)]。这些突变的基因与有缺陷的牙齿组织有关
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引用次数: 0
Determination of obstructive sleep apnea through the epworth test and cephalometry 通过爱普沃斯试验和头测术测定阻塞性睡眠呼吸暂停
Pub Date : 2019-08-09 DOI: 10.15406/jdhodt.2019.10.00493
Cruz-Vargas Lizbet Adriana, M. Guadalupe, González-Ramírez Alejandro de Jesús, Ce. Isaac, Galindo-Reyes Lilia Edith, Suárez-Franco José Luis
Sleep is a brain function. During sleep, control of respiration goes from being a semi-voluntary act to becoming a self-regulatory activity of highest biological priority. There are diverse physiological functions that the dream favors or allows and that are modified or suppressed after their deprivation as it is the conservation of energy; cerebral thermoregulation; cerebral detoxification; tissue restoration, memory and apprentice.1,2
睡眠是一种大脑功能。在睡眠过程中,呼吸控制从一种半自愿的行为变成了一种最高生物优先级的自我调节活动。有各种各样的生理功能是梦所支持或允许的,在它们被剥夺后被修改或抑制,因为它是能量守恒;大脑温度调节;脑解毒;组织修复,记忆和学徒,1,2
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引用次数: 0
Is it better to restore or extract deciduous teeth- a survey 乳牙修复好还是拔牙好
Pub Date : 2019-08-08 DOI: 10.15406/jdhodt.2019.10.00492
Sara Alshammery, N. Alturki, M. Alomran
treatment of these diseases requires an understanding of and, at times, modifying the child’s and family’s response to care. Behavior guidance is the process by which practitioners help patients identify appropriate and inappropriate behavior, learn problem solving strategies, and develop impulse control, empathy, and self-esteem. This process is a continuum of interaction involving the dentist and dental team, the patient, and the parent; its goals are to establish communication, alleviate fear and anxiety, deliver quality dental care, build a trusting relationship between dentist/staff and child/ parent, and promote the child’s positive attitude toward oral health care. Knowledge of the scientific basis of behavior guidance and skills in communication, empathy, tolerance, cultural sensitivity, and flexibility are requisite to proper implementation. Behavior guidance should never be punishment for misbehavior, power assertion, or use of any strategy that hurts, shames, or belittles a patient.
这些疾病的治疗需要了解,有时还需要改变儿童和家庭对护理的反应。行为指导是医生帮助患者识别适当和不适当的行为,学习解决问题的策略,培养冲动控制、同理心和自尊的过程。这个过程是一个连续的互动过程,涉及牙医和牙科团队、患者和家长;它的目标是建立沟通,减轻恐惧和焦虑,提供优质的牙科护理,建立牙医/工作人员与儿童/家长之间的信任关系,促进儿童对口腔保健的积极态度。行为指导的科学基础知识和沟通技巧,移情,宽容,文化敏感性和灵活性是正确实施的必要条件。行为指导不应该是对错误行为的惩罚,权力的主张,或使用任何伤害、羞辱或轻视病人的策略。
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引用次数: 0
Maxillary Sinus Pneumatization and Its Relationship with Vitamin D Deficiency; ACross Sectional Study 上颌窦通气及其与维生素D缺乏的关系横断面研究
Pub Date : 2019-08-07 DOI: 10.33140/jodh.03.02.5
Objectives: To identify any correlation and its severity with the levels of serum vitamin D with the level of maxillarysinus pneumatization.Study Design: Descriptive cross-sectional survey.Setting: Oral and Maxillofacial Department, Fatima Memorial Hospital, Lahore.Materials and Methods: A sample size of 100 subjects met the inclusion criteria. Serum Vitamin D levels of the patientswas done using liquid chromatography tandem mass spectrometry, also known as LC/MS/MS. While level of sinuspneumatization was recorded according to Sharan and Majdar classification of maxillary sinus pneumatization. Datawas collected and entered into the Statistical Package for Social Science (SPSS) version 25.0 for analysis. Parametricanalysis was performed that included the Pearson’s Chi- Square test to determine an association between excessivemaxillary sinus pneumatization and hypovitaminosis. A p-value of <0.05 was defined as the level of significance.Results: A statistically significant relationship was found between levels of hypovitaminosis and levels of pneumatizationwith a chi square value to be 0.002 (p<0.05) While there was no statistically significant relationship of age or genderwith levels of maxillary sinus pneumatization and hypovitaminosis D (p>0.05).Conclusion: There is a significant relationship between levels of hypovitaminosis and levels of pneumatisation.
目的:探讨血清维生素D水平与上颌窦通气水平的相关性及其严重程度。研究设计:描述性横断面调查。地点:拉合尔法蒂玛纪念医院口腔颌面科。材料与方法:样本量为100名符合纳入标准的受试者。采用液相色谱串联质谱法(LC/MS/MS)测定患者血清维生素D水平。根据上颌窦气化的Sharan和Majdar分类记录鼻窦气化程度。收集数据并输入社会科学统计软件包(SPSS) 25.0版本进行分析。进行参数分析,包括皮尔逊卡方检验,以确定上颌窦过度充气与维生素缺乏症之间的关系。p值为0.05)。结论:维生素缺乏症水平与肺气肿水平有显著相关性。
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引用次数: 0
Assessment of marginal adaptation of lithium disilicate and nanoceramic resin crowns using CAD/CAM system 应用CAD/CAM系统评价二硅酸锂与纳米陶瓷树脂冠的边际适应性
Pub Date : 2019-07-24 DOI: 10.15406/jdhodt.2019.10.00490
Vieira Lucas PL, Ávila Gisseli B, Franco Aline BG, Franco Amanda G, Carvalho Geraldo AP, D. Sérgio C, Ramos Elimário V
The aim of this study is to assess the marginal adaptation of different ceramic materials produced by the CEREC system (Sirona, Germany). An analog of the solid abutment Straumann (Straumann, Basel, Switzerland) measuring 5.5mm of height, with platform of 4.8mm, tilt from the axial wall of 6 degrees and chamfer finish line was used as a master model and scanned with an intraoral scanner (CEREC Omnicam). 20 machined crowns were obtained - 10 manufactured from lithium disilicate blocks (IpsE.maxCad, IvoclarVivadent, Liechtenstein, Germany), 10 manufactured from nanoceramic resin blocks (3M ESPE Lava Utimate, USA). The assessment was made using the Replica Technique (RT) and the cementation coating was measured using an optical microscope Mitutoyo (TM 500). Results show a mean marginal disadaptation of lithium disilicate crowns of 78.63µm, which is significantly larger than the one found for nanoceramic resin crowns - 63.15µm. It is possible to conclude that nanoceramic resin crowns have a better marginal adaptation than lithium disilicate ones. Notwithstanding, results found for both groups are within the clinically acceptable values for indirect restorations.
本研究的目的是评估CEREC系统(德国Sirona)生产的不同陶瓷材料的边际适应性。采用模拟实体基台Straumann (Straumann, Basel, Switzerland),高5.5mm,平台4.8mm,与轴向壁倾斜6度,倒角终点线作为主模型,使用CEREC Omnicam口内扫描仪进行扫描。获得了20个机械冠- 10个由二硅酸锂块(IpsE)制成。maxCad, IvoclarVivadent,列支敦士登,德国),10由纳米陶瓷树脂块(3M ESPE Lava ultimate,美国)制成。采用复制技术(RT)进行评估,采用Mitutoyo光学显微镜(TM 500)测量胶结涂层。结果表明,二硅酸锂冠的平均边际失适应值为78.63µm,明显大于纳米陶瓷树脂冠的63.15µm。因此,纳米陶瓷树脂冠具有比二硅酸锂冠更好的边缘适应性。尽管如此,两组的结果均在间接修复的临床可接受值范围内。
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引用次数: 0
Difference in Root Canal Length between Populations 不同人群根管长度的差异
Pub Date : 2019-06-28 DOI: 10.33140/jodh.03.02.3
Introduction: The objective of the study was to make the comparison of the root canal length of different types of teeth in black-Africans (Bantu)to that of Caucasians and Asians.Materials and Methods: Data from a prospective cross-sectional study of Bantu (Black Africans) subjects aged from 18 to 45 years who wereadmitted in Service of Conservative Dentistry of Kinshasa University, root canal length were compared with already published data from studiesinvolving Caucasians and Asians.Results: This study includes 720 subjects; 480 (66%) were female and 240 (34%) were male. A total of 818 teeth were examined with 1539root canals. The upper central incisor and the lower first molar predominated respectively in the maxilla and the mandible regions. There is asignificant difference between the canal length of Bantu and Asians in the palatal canal of the upper second molar by 3.1 mm (p= 0.00). Eightdifferent canals of Bantu were longer as compared to a single canal for Asians (p <0.05).This include the Vestibular (V) and palatine (P) canals of Bantu the first premolar (PM1), palatal of the second premolar (PM2), mesio-vestibular(MV), disto-vestibular (DV) and palatine (P) of the first molar (M1) mesio-vestibular and palatal of the second molar (M2). The lateral incisors(IL) (p= 0,01) and the canines (p= 0.12) of the Asians were longer than that of the Bantu. The Caucasians presented with longer canines thanBantu with a length difference of 1.7 mm (p= 0.11).Four Caucasians also presented with longer canals of the Mesio-Vestibular (MV) and mesiolingual (ML) of the two molars (M1 and M2) ascompared to one for Bantu are the longest (p <0.05).Exceptionally, the distal canal (D) of the second molar (M2) of the Bantu was longer than that of the Caucasians, with a length difference of 1.5 mm.Conclusion: The root canal length of Bantu is between than those of the most Asian and shortest Caucasian.
前言:本研究的目的是比较非洲黑人(班图人)与高加索人和亚洲人不同类型牙齿的根管长度。材料和方法:一项前瞻性横断面研究的数据来自于18至45岁的班图(非洲黑人)受试者,这些受试者在金沙萨大学的保守牙科服务中被录取,根管长度与已经发表的涉及高加索人和亚洲人的研究数据进行了比较。结果:本研究纳入720名受试者;其中女性480人(66%),男性240人(34%)。共检查牙齿818颗,根管1539根。上颌和下颌骨分别以上中切牙和下第一磨牙为主。班图人与亚洲人上第二磨牙腭管长度差异有统计学意义(p= 0.00),差异达3.1 mm。班图人的8条不同的运河比亚洲人的1条运河更长(p <0.05)。这包括班图第一前磨牙(PM1)的前庭(V)和腭(P)管,第二前磨牙的腭(PM2),第一磨牙的中前庭(MV),散前庭(DV)和腭(P) (M1),第二磨牙的中前庭和腭(M2)。亚洲人的侧切牙(IL) (p= 0.01)和犬齿(p= 0.12)均比班图人长。白种人犬齿比班图人长1.7 mm (p= 0.11)。与班图人相比,4名高加索人两磨牙(M1和M2)的中前庭(MV)和中舌(ML)管最长(p <0.05)。特别的是,班图人第二磨牙远端根管(M2)比白种人长,相差1.5 mm。结论:班图人的根管长度介于大多数亚洲人和最短的白种人之间。
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引用次数: 2
Knowledge and awareness of sickle cell anemia among dental students in Riyadh Elm University 利雅得榆树大学牙科学生镰状细胞性贫血的知识和意识
Pub Date : 2019-06-10 DOI: 10.15406/jdhodt.2019.10.00488
Asma Al Meslet, Heba Al Hamedi, Hanan Al Zhrani, Khayria Al Somaly, Anfal Al Doukhi
Anemia is a condition defined as lack of red blood cell or hemoglobin which is carries oxygen from the lungs to the tissues.1 Sickle cell anemia is an inherited blood disorder (IBD) caused by a mutation of the hemoglobin gene that affects hemoglobin structure and morphologic in erythrocytes; resulting in the formation of abnormal, sickle-shaped red blood cells.2 In SCA there is reducing the flow of the blood and oxygen into the body organs and impedes blood flow through small capillaries will cause blockage of blood vessels (i.e., vaso-occlusion).3 Epidemiology of Sickle Cell Disease in the United States, about 72 000 people and 2 million are carriers.4 In Africa, more than 200 000 infants are born yearly with SCD.5 The Eastern Province of Saudi Arabia is known to have one of the highest prevalence rates of SCD worldwide.6,7
贫血是一种缺乏将氧气从肺部输送到组织的红细胞或血红蛋白的疾病镰状细胞性贫血是一种遗传性血液疾病(IBD),由血红蛋白基因突变引起,影响红细胞中的血红蛋白结构和形态;镰状的导致形成异常的镰状红细胞的在SCA中,血液和氧气进入身体器官的流量减少,血液通过小毛细血管的流动受阻,会导致血管阻塞(即血管闭塞)3 .镰状细胞病的流行病学在美国,约有7.2万人和200万人是镰状细胞病的携带者在非洲,每年有超过20万婴儿出生时患有SCD。沙特阿拉伯东部省份是世界上SCD患病率最高的地区之一
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引用次数: 1
Fused primary supernumerary tooth associated with maxillary primary lateral incisor: a case report 上颌初级侧切牙融合多生牙1例报告
Pub Date : 2019-05-30 DOI: 10.15406/jdhodt.2019.10.00487
V. Mehta, Shahnaz Mansoori
Fusion is defined as a single enlarged tooth or joined tooth in which the tooth count reveals a missing tooth when the anomalous tooth is counted as one.1 It is a dental twinning anomaly and has been described by many terms like double teeth, connated tooth, conjoined teeth or twinned teeth. Clinically, it may appear as normal sized or large, depending upon the stage at which embryological union occurs during development. It is commonly confused with gemination which is an incomplete attempt of one tooth bud to divide into two. The frequency of double teeth in deciduous teeth is greater, with a reported prevalence from 0.5 to 2.5% and the occurrence is higher amongst Asian populations.1 Incisors and canines are the most commonly affected teeth in both dentitions.1 Supernumerary tooth arises due to an anomaly in number of teeth due to an excessive dental lamina activity.2 Supernumerary teeth occur rarely in the primary dentition as compared to permanent dentition.3 The prevalence of supernumerary teeth in primary dentition is 0.2-1.9%.4 Males are more commonly affected as compared to females.5 A frequent finding in fusion of primary teeth is the congenital absence of corresponding permanent teeth. The prevalence of tooth fusion in the primary dentition is 0.52.5%.6
融合被定义为单个增大的牙齿或连接的牙齿,当异常牙齿被计数为一颗时,牙齿计数显示缺牙它是一种牙齿孪生异常,被描述为许多术语,如双牙,合生牙,连体牙或双生牙。在临床上,它可能表现为正常大小或大,这取决于胚胎结合在发育过程中发生的阶段。它通常与长牙相混淆,长牙是一个牙芽分裂成两个的不完全尝试。乳牙中出现双牙的频率较高,据报道发病率为0.5%至2.5%,其中亚洲人的发生率较高门齿和犬齿是两种牙齿中最常受影响的牙齿多生牙齿是由于牙板活动过度而导致牙齿数目异常而产生的与恒牙相比,初级牙列很少长出多余的牙齿乳牙中多生牙的发生率为0.2% ~ 1.9%与女性相比,男性更容易受到影响在乳牙融合中经常发现的是先天性的恒牙缺失。原牙列牙融合率为0.52.5%
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引用次数: 0
The Influence of Age and Gender on Mandibular Indices among the Libyan Population 利比亚人口中年龄和性别对下颌指数的影响
Pub Date : 2019-05-29 DOI: 10.33140/jodh.03.02.2
Radiographic Mandibular Indices serve as easy and relatively cheap tools for evaluating bone mineralization.Objectives: To examine the effect of age and gender on three mandibular indices: the panoramic mandibular index(PMI), the mandibular ratio (MR) and the mandibular cortical index (MCI), among Libyan population.Methods: The three indices were measured on 317 digital (OPGs) of adult humans (155 males, 162 females). Thesample was divided into six age groups (from 18-25 years through 56-65 years). The measurements were analyzedfor interactions with age and sex, using SPSS (Statistical Package for Social Studies) software version no. 22. Thetests employed were two way ANOVA, the unpaired T-test and chi-square test.Results: The mean PMI fluctuated between 0.37 s.d. 0.012 and 0.38 s.d. 0.012. among the sixth age groups. One-wayANOVA statistical test revealed no significant of age on PMI. On the other hand gender variation has effect on PMI,since independent sample t-test disclosed that the difference between the male and female PMI means statisticallysignificant. ANOVA test showed that the means of MR among age groups showed a negative correlation i.e. MR meandeclined from 3.01 in 18-25 age groups to 2.7 in 55-65 age groups. In contrary, the gender showed no effect on MRaccording two sample t-test at p> 0.05. In regards with MCI, statistical analysis showed that it affected by age thatis C1 was decreasing by age while C2 and C3 were increased by age. Using chi square test the result indicated thatthere is a significant difference among the different age group and the two genders in MCI readings.Conclusion: PMI was influenced significantly by age but minimally by the gender. MR is not affected by gender buthas a negative correlation with age. MCI is affected by both age and gender
放射学下颌骨指数是评估骨矿化的简单和相对便宜的工具。目的:探讨年龄和性别对利比亚人群下颌全景指数(PMI)、下颌比例(MR)和下颌皮质指数(MCI)的影响。方法:对317例成人(男性155例,女性162例)的数字(opg)进行3项指标测定。样本被分为6个年龄组(从18-25岁到56-65岁)。使用SPSS (Statistical Package for Social Studies)软件对测量结果与年龄和性别的相互作用进行分析。22. 采用双因素方差分析、非配对t检验和卡方检验。结果:PMI均值在0.37 s.d 0.012 ~ 0.38 s.d 0.012之间波动。在第六个年龄组中。单因素方差分析显示年龄对PMI的影响不显著。另一方面,性别差异对PMI有影响,因为独立样本t检验表明,男性和女性PMI之间的差异具有统计学意义。方差分析显示各年龄组间MR均值呈负相关,MR均值由18-25岁年龄组的3.01下降到55-65岁年龄组的2.7。两样本t检验p> 0.05,性别对mri无影响。在MCI方面,统计分析显示受年龄的影响,C1随年龄的增长而降低,C2和C3随年龄的增长而升高。卡方检验的结果表明,不同年龄组和性别之间的MCI读数存在显著差异。结论:PMI受年龄影响显著,性别影响较小。MR不受性别影响,但与年龄呈负相关。轻度认知障碍受年龄和性别的影响
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引用次数: 0
Delayed tooth eruption and its pathogenesis in paediatric patient: a review 儿科患者延迟出牙及其发病机制综述
Pub Date : 2019-05-28 DOI: 10.15406/jdhodt.2019.10.00486
Haneen Alshukairi
Human eruption is a unique developmental process in the organism. Delayed tooth eruption is the emergence of a tooth into the oral cavity at a time that deviates significantly from norms established for different races, ethnicities, and sexes. The eruption time of primary teeth is very important for planning and diagnosing of certain growth developments. The present article gave a review on delayed tooth eruption and its pathogenesis.
人体出疹是机体独特的发育过程。延迟出牙是指牙齿进入口腔的时间明显偏离了不同种族、民族和性别所建立的规范。乳牙的萌牙时间对某些生长发育的规划和诊断非常重要。本文就迟发性牙萌及其发病机制作一综述。
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引用次数: 12
期刊
Journal of dental health, oral disorders & therapy
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