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Team-based learning student assessment instrument in Brazilian dental education: a validation study 基于团队学习的学生评估工具在巴西牙科教育:一项验证研究
Pub Date : 2019-05-01 DOI: 10.15406/jdhodt.2019.10.00481
F. B. Souza, Elaine Judite de Amorim Carvalho, Bruna de Castro, Emmanoel Matheus de Oliveira Matos, Ingrid Melo Schüler Arreguy
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引用次数: 2
Hegab TMJ Splint (HTS) Hegab TMJ夹板(HTS)
Pub Date : 2019-04-17 DOI: 10.15406/jdhodt.2019.10.00480
A. Hegab
Successful treatment of the TMJ internal derangement is based on understanding the biomechanical performance of the TMJ and subsequently to understand the biomechanical changes within the TMJ resulted from the occlusal splint to achieve harmonious relationships among teeth, joints, and muscles. As the disc displaced anteriorly, the elevator muscles continue to seat the condyle in the fossa resulting in decreasing the joint space and posterior-superiorly movement of the condyle. The aim of the splint is to move the condyle downward and foreword besides movement of the disk toward the normal position. These movements resulting in increasing the joint space, decreasing the joint pressure especially on the posterior attachment of the articular disk. Moreover; the vertical thickness of the occlusal splint return the normal physiologic function of the masticatory mechanism by relax the masticatory muscles by decreasing the electrical muscle activity and re-establish the disk condyle relationship (disc re-capture).4
成功治疗TMJ内部紊乱的基础是了解TMJ的生物力学性能,随后了解咬合夹板导致的TMJ内部生物力学变化,以实现牙齿、关节和肌肉之间的和谐关系。当椎间盘向前移位时,提升肌继续将髁突固定在窝内,导致关节间隙减小和髁突的后向上运动。夹板的目的是使髁突向下和向前移动,同时使椎间盘向正常位置移动。这些运动增加了关节间隙,减少了关节压力,特别是在关节盘的后附着处。此外;咬合夹板的垂直厚度通过减少咀嚼肌的电活动使咀嚼肌放松,重建椎间盘髁关系(椎间盘重捕),从而恢复咀嚼机制的正常生理功能
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引用次数: 1
Characterization of two orthodontic NiTi wires regarding their structures and phase transformation temperatures 两种正畸镍钛丝的结构和相变温度表征
Pub Date : 2019-03-05 DOI: 10.15406/JDHODT.2019.10.00468
A. C. A. D. Souza, L. N. Souza, A. Drummond, V. Buono
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引用次数: 0
Efficacy of Car T-Cell Therapy in Head and Neck Cancers- A Meta-Analysis Car - t细胞治疗头颈癌的疗效-荟萃分析
Pub Date : 2019-03-01 DOI: 10.33140/jodh.03.02.1
Background: Cancer, defined by the World Health Organization (WHO) is “a large group of diseases characterized by the growth of abnormal cells beyond their usual boundaries that can then invade adjoining parts of the body and/or spread to other organs”. From extensive surgical excisions, radiotherapy, laser therapy to immunotherapies, various treatment strategies have been proposed and implemented so far but unfortunately none could improve the five year survival rate of the patients globally. Immunotherapy, being one amongst them, is a type of cancer treatment that boosts the body’s natural defenses to fight against cancer. The current concept of immunotherapy involves Chimeric antigen receptor or the CAR T-Cell therapy which involves alterations and modifications of T cells to fight cancer cells better. Until recently, the use of CAR T-cell therapy has been restricted to small clinical trials, largely in patients with advanced blood cancers and has also shown a promising window of hope in head and neck (especially oral) cancers as well. But these treatments have nevertheless captured the attention of the people because of the remarkable responses they have produced in some patients for whom all other treatments had stopped working. The current concept of immunotherapy involves the cancer vaccines making use of CAR T-cells which are the most powerful antigen presenting cells for the induction of antigen specific T cell response. This evidence based study therefore aims to highlight the clinical perspective of CAR T-Cell based immunotherapy in oral and other head and neck cancers. Aim: Assessment of efficacy of Car T-Cell Therapy in head and neck Malignancies. Research Question: Is Car T-Cell Therapy actually effective in treating head and neck cancers? Materials and Methods: Study sample included review of 70 research articles, based on scientific data bases from the English literature based COCHRANE collaboration having a definite RCT (Randomized Control Trial). The literature was studied, analyzed and assessed; comparison was made on their p (probability) values between various techniques in terms of their sensitivity and specificity. The articles were scrutinised based on the criterion for meta-analysis and finally 11 study articles were chosen for the study. Result and Conclusion: Due to its unique individual characteristics, it helps combat against the cancer cells at its very inception. Promises a complete and permanent cure for malignancies at the grass root level. It has a sensitivity and specificity of greater than 80-90% and enhances recovery rate from 40-50% to more than 90%. So on a bulls eye view, we can say that as the already existing techniques of oral cancer treatment are very superficial and not very significant, Car T-Cell therapy tends to bring about a paradigm shift in oral cancer treatment thereby giving a new ray of hope to cancer ailing patients.
背景:世界卫生组织(世卫组织)对癌症的定义是“一大组疾病,其特征是异常细胞的生长超出其通常的边界,然后可以侵入身体的邻近部位和/或扩散到其他器官”。从广泛的手术切除、放射治疗、激光治疗到免疫治疗,各种治疗策略已经提出并实施,但不幸的是,没有一种可以提高全球患者的五年生存率。免疫疗法就是其中之一,它是一种癌症治疗方法,可以增强身体的自然防御能力来对抗癌症。目前的免疫治疗概念包括嵌合抗原受体或CAR - T细胞治疗,其中包括T细胞的改变和修饰,以更好地对抗癌细胞。直到最近,CAR - t细胞疗法的使用仅限于小型临床试验,主要用于晚期血癌患者,并且在头颈部(特别是口腔癌)癌症中也显示出希望之窗。然而,这些治疗方法还是引起了人们的注意,因为它们在一些其他所有治疗方法都无效的病人身上产生了显著的反应。目前的免疫治疗概念包括利用CAR - T细胞的癌症疫苗,CAR - T细胞是诱导抗原特异性T细胞反应的最强大的抗原提呈细胞。因此,这项基于证据的研究旨在强调基于CAR - t细胞的免疫疗法在口腔癌和其他头颈癌中的临床应用前景。目的:评价Car - t细胞治疗头颈部恶性肿瘤的疗效。研究问题:Car - t细胞疗法对头颈癌真的有效吗?材料和方法:研究样本纳入了70篇研究论文,基于COCHRANE英文文献合作的科学数据库,具有明确的RCT(随机对照试验)。对文献进行研究、分析和评估;比较了不同技术的p(概率)值的敏感性和特异性。根据荟萃分析的标准对文章进行仔细审查,最终选择了11篇研究文章进行研究。结果与结论:由于其独特的个体特性,它从一开始就有助于对抗癌细胞。承诺在基层彻底和永久治愈恶性肿瘤。灵敏度和特异度均大于80-90%,回收率由40-50%提高到90%以上。因此,从长远来看,我们可以说,由于现有的口腔癌治疗技术非常肤浅,意义不大,Car - t细胞疗法往往会带来口腔癌治疗的范式转变,从而给癌症患者带来新的希望。
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引用次数: 0
Indirect versus direct pulp capping: reactionary versus reparative dentin 间接与直接牙髓盖盖:反应性与修复性牙本质
Pub Date : 2019-02-27 DOI: 10.15406/jdhodt.2019.10.00466
M. Goldberg
They colonize and enlarge the dentino-enamel junction, widening the gap between the carious enamel and the soft carious dentin. Debris such as cell walls remnants remaining after by vegetal chewing, and fibers issued from muscle-like ‘meat’ may also be present. The soft carious dentin located beneath this zone of food debris is a mixture of bacteria and demineralized dentin that may be removed without drilling, using only manually sharp excavators. At the surface of this layer, the carious dentin is fully demineralized. The soft carious dentin displays enlarged tubules, containing bacteria acting within these reservoirs. This layer is totally deprived of peritubular dentin. From the surface to the depth of the lesion, the dentin progressively is less demineralized. Apatitic crystals provide some consistency to this layer. Gradually peritubular dentin reappears. The next carious layer includes a mixture of infected tubules filled by cariogenic bacteria and bacteria-free tubules. A continuous ring of peritubular dentin surrounds the lumens of the canaliculi. Intertubular dentin gradually reach the original structure. Demineralization and reprecipitation occurs at the surface of apatitic crystals, increasing their size in three directions. In the sound dentin, crystals display the following main dimensions: 34Å thick, 139Å wide and 250Å long. In the carious dentin, the crystals increase in thickness, and enlarge. Measurements indicate a 90Å (65-70Å) thickness x 300Å in width, and a length of x 500Å. Crystals reach a final diameter of 120-135Å according to Takuma et al.1
它们在牙本质-牙釉质交界处定居并扩大,扩大了蛀牙釉质和软蛀牙本质之间的间隙。植物咀嚼后残留的细胞壁等碎片,以及类似肌肉的“肉”产生的纤维也可能存在。位于食物残渣下面的软牙本质是细菌和脱矿牙本质的混合物,不需要钻孔就可以去除,只需要使用手动锋利的挖掘机。在这一层的表面,龋齿本质完全脱矿。软龋牙本质显示增大的小管,这些小管中含有细菌。这一层完全没有小管周围的牙本质。从损伤表面到深度,牙本质的脱矿程度逐渐减少。磷灰石晶体使这一层具有一定的稠度。逐渐地,小管周围牙本质重新出现。下一层龋层包括充满致龋细菌和无细菌小管的感染小管的混合物。一连续的小管周围牙本质环围绕着小管腔。管间牙本质逐渐恢复到原来的结构。磷灰石晶体表面发生脱矿和再沉淀,在三个方向上增大其尺寸。在健全的牙本质中,晶体显示以下主要尺寸:34Å厚,139Å宽和250Å长。在蛀牙本质中,晶体厚度增加,扩大。测量表明90Å (65-70Å)的厚度x 300Å的宽度,和x 500Å的长度。根据Takuma等人的研究,晶体最终直径可达120-135Å
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引用次数: 4
Lip Repositioning: A Secret to Magnificent Smile 嘴唇重新定位:灿烂微笑的秘密
Pub Date : 2019-02-23 DOI: 10.33140/jodh.03.01.4
Saurabh Anand Thawrani, Komal S Thawrani
Aesthetics now a day became a demand for a fast growingpopulation. Aesthetic dentistry provides fantastic solutions mostof the times to enhance the way the people look, which in turnenhance self-confidence. A smile conveys a friendly nature, andreflects happiness and confidence. A smile is an important non-verbalmethod of communication and is an interaction between the teeth,the lip framework, and the gingival scaffold [1]. In the westernworld, a medium smile line with minimal gingival display (GD) isconsidered to be the most pleasing. When an excessive amount ofgingiva is visible while smiling, this condition is commonly referredto as a ‘‘gummy smile’’ and it is found frequently in the generalpopulation. In a sample of over 450 adults, aged 20 to 30 years, 7%of men and 14% of women were found to have a gummy smile [2].Excessive gingival display is associated with different etiologies,which must be identified before treatment. It is imperative, therefore,for the clinician to evaluate the essentials of the patient’s smile, andconsider the dynamic relationship between the patient’s dentition,gingiva, and lips while smiling [1,3].
如今,美学已成为快速增长的人口的一种需求。牙科美容在大多数时候提供了奇妙的解决方案来改善人们的外表,从而增强自信。微笑传达了一种友好的天性,反映了快乐和自信。微笑是一种重要的非语言交流方式,是牙齿、唇架和牙龈支架之间的相互作用[1]。在西方世界,中等的微笑线和最小的牙龈显示(GD)被认为是最令人愉快的。当微笑时露出过多的牙龈时,这种情况通常被称为“粘牙微笑”,在一般人群中很常见。在一项超过450名年龄在20到30岁之间的成年人的样本中,7%的男性和14%的女性被发现有一个黏人的微笑[2]。过度的牙龈显示与不同的病因有关,必须在治疗前确定。因此,临床医生必须评估患者微笑的本质,并考虑患者微笑时牙列、牙龈和嘴唇之间的动态关系[1,3]。
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引用次数: 0
Laser therapy on dental emergencies of patients with hemophilia as an alternative for hemostasis and reducing the use of factor VIII concentrate 激光治疗血友病患者牙科急诊作为止血和减少VIII浓缩因子使用的替代方法
Pub Date : 2019-02-20 DOI: 10.15406/jdhodt.2019.10.00464
Laura Beatriz Isidro Olán, Marco Antonio Rueda Ventura, C. A. Nájera, Armando Najera Castro
Al (Gallium and aluminum arsenide); He, Ne (hHelium, neon). High intensity laser machines produce visible and physical effects in oral tissues and can be a substitute for cold scalpel or for conventional high rotatory instrument. Er:YAG (Erbium:Ytrium-Aluminum-Garnet) Laser has bactericidal effects against periodontal pathogenic bacteria and also eliminate bacterial endotoxins. Different tissue effects according to the temperature reached in a laser machine are showed in Table 1. In these cases series the temperature oscilated between 70-90 Celsius degrees to achieve hemostasis in different types of emergency oral bleeding. Table 1 Tissue effects according to the temparature reached
Al(镓和砷化铝);He, Ne (hHelium, neon)。高强度激光切割机可在口腔组织中产生可见的物理效应,可替代冷手术刀或传统的高旋转器械。铒:钇-铝-石榴石激光对牙周致病菌有杀菌作用,并能消除细菌内毒素。不同温度下的组织效应如表1所示。在这些病例中,温度在70-90摄氏度之间振荡,以实现不同类型的紧急口腔出血的止血。表1不同温度下的组织效应
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引用次数: 3
The healthy root pulp, degradation and regeneration 健康的根髓,降解和再生
Pub Date : 2019-02-06 DOI: 10.15406/jdhodt.2019.10.00462
M. Goldberg
2. In the root, the Hopewell-Smith and Tomes granular layers constitute the outer limits (each of these layers being 8-15μm thick, with a total thickness approximately of 30μm). Both layers are located beneath the dentino-enamel or the dentinocementum junctions. In the outer mantle dentin, they contain a few tubules that are bent, and display minute diameter. In the granular layer, the peripheral layers include unfilled interglobular spaces (or calcospheritic structures), apparently empty but actually containing GAGs. These outer layers constitute the limits of the sound circumpulpal dentin (primary and secondary dentins). The pulp volume displays variable thickness, depending the age of the tooth.1
2. 在根部,Hopewell-Smith和Tomes颗粒层构成了外层边界(每层厚度为8-15μm,总厚度约为30μm)。这两层都位于牙本质-牙釉质或牙本质-牙本质交界处以下。在外地幔牙本质中,它们含有一些弯曲的小管,直径很小。在颗粒层中,外围层包括未填充的球间空间(或钙球质结构),表面上是空的,但实际上含有gag。这些外层构成了健全的牙髓周围牙本质(初级和次级牙本质)的界限。牙髓的厚度随牙龄的不同而变化
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引用次数: 2
LSTR 3mix-MP Important Efficacy Particularly Antibacterial and Periapical Lesionsduring Conservative Treatment in the Dentistry like RCT and Others EndodonticsManagement: Case Studies lst3mix - mp在牙科保守治疗中的重要功效,特别是抗菌和根尖周围病变,如RCT和其他牙髓治疗:案例研究
Pub Date : 2019-01-23 DOI: 10.33140/jodh.03.01.3
Local sterilization and tissue repair which generally termed as LSTR, brings a radicular change in the field of conservativedentistry. Efficacy against antibacterial environment and non-surgical healing of periapical lesions much better thancalcium hydroxide. LSTR 3Mix-MP, Using an antibacterial drug combination, therapy is a novel caries, pulpal treatmentof primary tooth and root canal treatment. LSTR 3Mix-MP aims to eliminate causative bacteria from lesions and aftersterilization, the host’s natural tissue recovery process usually the lesions are repaired or resolved. LSTR 3Mix MP whereTAP (triple antibiotics paste) such as: Metronidazole, Ciprofloxacin, Minocycline and Vehicle MP Macrogol/polyethyleneglycol and propylene glycol used to prepare. TAP has great antibacterial efficacy particularly against enterococci whichremains after successful root canal treatment, effective eradication of the causative microorganisms during root canaltreatment procedures. Residual infection in Root canal therapy has always been an area of interdermind or vague fora treating dental surgeon. Lesion sterilization and tissue repair (LSTR) therapy is a non-surgical or non-conventionalendodontic treatment procedure that involves non-instrumentation or minimal instrumentation followed by placement ofa triple antibiotic paste in a medication along with Macrogol and Propylene glycol.
局部灭菌和组织修复通常被称为LSTR,在保守牙科领域带来了根本性的变化。对抗菌环境和根尖周围病变的非手术愈合效果明显优于氢氧化钙。LSTR 3Mix-MP,采用抗菌药物联合治疗,是一种新型的治疗龋齿、牙髓及根管的治疗方法。LSTR 3Mix-MP旨在消除病变中的致病菌,并在灭菌后,使宿主的自然组织恢复过程通常使病变得到修复或解决。LSTR 3Mix MP其中etap(三重抗生素膏剂)如:甲硝唑、环丙沙星、米诺环素和载药MP大聚乙二醇/聚乙二醇和丙二醇使用配制。TAP具有很强的抗菌效果,特别是对成功根管治疗后残留的肠球菌,在根管治疗过程中有效根除致病微生物。根管治疗中的残留感染一直是牙外科医生研究和模糊的领域。病变灭菌和组织修复(LSTR)治疗是一种非手术或非传统的根管治疗程序,包括无器械或最小器械,随后在药物中放置三种抗生素膏体以及大聚乙二醇和丙二醇。
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引用次数: 0
Observers Agreement in Perception of Non-Cavitated Approximal Dental Cariesby Intraoral Digital CCD Radiography at Different Exposure Parameters andCorresponding Required Radiation Dose 不同照射参数及所需辐射剂量下口内数字CCD成像对非空化近似龋的感知一致
Pub Date : 2019-01-07 DOI: 10.33140/jodh.03.01.1
Mohamed Mehanny, Marcel Noujeim
Objectives: To evaluate the diagnostic accuracy of Charged Coupled device (CCD) in detection of Non- Cavitated Approximalcaries at different exposure parameters in relation to radiation dose in vitro.Study Design: Seventy-eight surfaces of extracted teeth were inserted in acid gel to create non-cavitated proximal carieswith different depth, and then Radiographs have been taken to all teeth by CCD sensor. Radiographs were interpreted bythree observers. The lesions were classified as (N) No lesion, (D1) Less than ½ enamel thickness, (D2) more than halfway ofenamel but not involve DEJ. (D3) Dentin caries. Teeth were randomly selected for histological analysis after consensus fromthree oral and maxillofacial radiologists as Gold standard. The corresponding radiation dose was measured by unfors meterdevice at different exposure parameters.Results: The histological examination showed that the distribution of lesions was 39.8% Sound, both enamel lesions areequal 17.8%, Dentin lesions 24.6.The sensitivity and specificity of CCD to detect normal surfaces were 0.95, D1 was 0.37, D2 was 0.74 and D3 was 0.86. Asthe lesions depth increased, the sensitivity increased.The higher image quality was produced by using exposure parameters (70 KvP, 160 ms) and (70 KvP, 200 ms). While, (60KvP, 200 ms) and (60 KvP, 250 ms) produced the worse image quality.Conclusion: Regard the balance between the higher diagnostic accuracy of digital images and minimum radiation dose:using exposure parameters as (70 KvP, 160 ms) is considered the best image quality and relative dose (81 mSv). While, (70KvP, 125ms) and (66 KvP, 160 ms) are little bit lower quality and corresponding dose are (63), (73) respectively. Although(70 KvP, 200 ET) produce higher image quality but its relative dose is high (101mSv).
目的:评价电荷耦合器件(CCD)在不同暴露参数下检测非空化近似龋的诊断准确性与体外辐射剂量的关系。研究设计:将拔牙的78个表面插入酸性凝胶中,形成不同深度的无空蚀近端龋,然后通过CCD传感器对所有牙齿拍摄x线片。x光片由三个观察者解读。病变分为(N)无病变,(D1)牙釉质厚度小于1 / 2,(D2)牙釉质厚度大于一半,但不涉及DEJ。(D3)牙本质龋齿。经三名口腔颌面放射科医师一致同意后,随机选择牙齿进行组织学分析作为金标准。在不同的照射参数下,用unfors计量仪测量相应的辐射剂量。结果:组织学检查显示病变分布为39.8%,两种牙釉质病变均为17.8%,牙本质病变为24.6%。CCD检测法向表面的灵敏度和特异性分别为0.95,D1为0.37,D2为0.74,D3为0.86。随着病变深度的增加,敏感性增加。使用曝光参数(70 KvP, 160 ms)和(70 KvP, 200 ms)可以获得更高的图像质量。而(60KvP, 200 ms)和(60KvP, 250 ms)产生的图像质量较差。结论:将数字影像较高的诊断准确率与最小辐射剂量相权衡,以(70 KvP, 160 ms)照射参数为最佳图像质量,相对剂量为81 mSv。(70KvP, 125ms)和(66 KvP, 160 ms)质量稍低,相应剂量分别为(63)、(73)。虽然(70 KvP, 200 ET)产生较高的图像质量,但其相对剂量高(101mSv)。
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引用次数: 0
期刊
Journal of dental health, oral disorders & therapy
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