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Analysis of a high-dimensional free boundary problem on tumor growth with time-dependent nutrient supply and inhibitor action 分析肿瘤生长的高维自由边界问题(营养供应和抑制剂作用随时间变化
IF 2.4 2区 数学 Q1 MATHEMATICS Pub Date : 2024-10-23 DOI: 10.1016/j.jde.2024.10.020
Yuehong Zhuang
This paper is concerned with a free boundary problem modeling tumor growth with time-dependent nutrient supply and inhibitor action. We highlight in this paper that the spatial domain occupied by the tumor is set to be n-dimensional for any n3, and it is taken into account that the nutrient supply ϕ(t) and the inhibitor injection ψ(t) on the tumor surface are time-varying in this problem. The high-dimensional setting of the problem makes the proof of the existence of radial stationary solutions and the accurate determination of their numbers highly nontrivial, in which we have developed a new method that is different from the previous work by Cui and Friedman [11]. We can give a complete classification of the radial stationary solutions to this problem under different parameter conditions, and also explore the asymptotic behavior of the transient solution for small c:=c1+c2 in the case that ϕ(t) and ψ(t) have finite limits as t.
本文关注的是一个自由边界问题,它模拟了肿瘤生长与时间相关的营养供应和抑制剂作用。我们在本文中强调,肿瘤占据的空间域设定为 n⩾3,并且考虑到该问题中肿瘤表面的营养供应 ϕ(t) 和抑制剂注射 ψ(t) 是时变的。该问题的高维设置使得证明径向静止解的存在和精确确定其数目变得非常困难,为此我们开发了一种不同于 Cui 和 Friedman [11] 以前研究的新方法。我们可以给出该问题在不同参数条件下的径向静止解的完整分类,还可以探索在小 c:=c1+c2 的情况下,ϕ(t) 和 ψ(t) 随着 t→∞ 具有有限极限的瞬态解的渐近行为。
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引用次数: 0
Symmetry-breaking bifurcation analysis of a free boundary problem modeling 3-dimensional tumor cord growth 模拟三维肿瘤脐带生长的自由边界问题的对称破缺分岔分析
IF 2.4 2区 数学 Q1 MATHEMATICS Pub Date : 2024-10-22 DOI: 10.1016/j.jde.2024.10.019
Junying Chen, Ruixiang Xing
In this paper, we study a free boundary problem modeling the growth of 3-dimensional tumor cords. Since tumor cells grow freely in both the longitudinal and cross-sectional directions of blood vessels, the investigation of symmetry-breaking phenomena in both directions is biologically very reasonable. This forces the possible bifurcation value γm,n to be dependent on two variables m and n. Some monotonicity properties of the possible bifurcation value μn or μj obtained in Friedman and Hu (2008) [1] and He and Xing (2023) [2] no longer hold here, which brings a great challenge to the bifurcation analysis. The novelty of this paper lies in determining the order of γm,n for m2+n2. Together with periodicity and symmetry, we propose an effective method to avoid the need for the monotonicity of γm,n. We give symmetry-breaking bifurcation results for every γm,n>0.
本文研究了模拟三维肿瘤索生长的自由边界问题。由于肿瘤细胞可在血管的纵向和横向自由生长,因此研究两个方向的对称性破坏现象在生物学上是非常合理的。Friedman 和 Hu (2008) [1]以及 He 和 Xing (2023) [2]中得到的可能分叉值 μn 或 μj 的一些单调性在这里不再成立,这给分叉分析带来了巨大挑战。本文的新颖之处在于确定了 m2+n2 的 γm,n 阶数。结合周期性和对称性,我们提出了一种有效的方法来避免γm,n 的单调性。我们给出了每个 γm,n>0 的对称性破缺分岔结果。
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引用次数: 0
Nonconvex optimal control problems for semi-linear neutral integro-differential systems with infinite delay 具有无限延迟的半线性中性整微分系统的非凸优化控制问题
IF 2.4 2区 数学 Q1 MATHEMATICS Pub Date : 2024-10-22 DOI: 10.1016/j.jde.2024.10.018
Hai Huang , Xianlong Fu
In this work, by using the theory of fundamental solution and resolvent operators, we investigate the existence of solutions for Bolza optimal control problems for a semi-linear neutral integro-differential equation with infinite delay. It is stressed that both the integral cost functional and the admissible set do not require convexity conditions other than the existing literature. Meanwhile, the existence of time optimal control to a target set is also considered and obtained by limit arguments. Finally, we provide a example to demonstrate the applications of our main results.
在这项工作中,我们利用基本解和解析算子理论,研究了具有无限延迟的半线性中性整微分方程的博尔扎最优控制问题的解的存在性。我们强调,积分代价函数和可接纳集均不需要现有文献以外的凸性条件。同时,我们还考虑了目标集时间最优控制的存在性,并通过极限论证得到了这一结果。最后,我们举例说明了主要结果的应用。
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引用次数: 0
On certain degenerate and singular elliptic PDEs IV: Nondivergence-form operators with logarithmic degeneracies or singularities 论某些退化和奇异的椭圆 PDE IV:具有对数退化或奇异性的非分歧形式算子
IF 2.4 2区 数学 Q1 MATHEMATICS Pub Date : 2024-10-22 DOI: 10.1016/j.jde.2024.10.017
Diego Maldonado
Harnack inequalities for nonnegative strong solutions to nondivergence-form elliptic PDEs with degeneracies or singularities of logarithmic type are proved. The results are developed within the Monge-Ampère real-analytic and geometric tools associated to certain convex functions.
证明了具有对数类型退化或奇异性的非辐散形式椭圆 PDEs 的非负强解的哈纳克不等式。这些结果是在与某些凸函数相关的 Monge-Ampère 实解析和几何工具中得到的。
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引用次数: 0
Dispersive estimates for Maxwell's equations in the exterior of a sphere 麦克斯韦方程在球体外部的分散估计
IF 2.4 2区 数学 Q1 MATHEMATICS Pub Date : 2024-10-22 DOI: 10.1016/j.jde.2024.10.024
Yan-long Fang , Alden Waters
The goal of this article is to establish general principles for high frequency dispersive estimates for Maxwell's equation in the exterior of a perfectly conducting ball. We construct entirely new generalized eigenfunctions for the corresponding Maxwell propagator. We show that the propagator corresponding to the electric field has a global rate of decay in L1L operator norm in terms of time t and powers of h. In particular we show that some, but not all, polarizations of electromagnetic waves scatter at the same rate as the usual wave operator. The Dirichlet Laplacian wave operator L1L norm estimate should not be expected to hold in general for Maxwell's equations in the exterior of a ball because of the Helmholtz decomposition theorem.
本文的目的是为麦克斯韦方程在完全导电球外部的高频色散估计建立一般原则。我们为相应的麦克斯韦传播子构建了全新的广义特征函数。我们证明了与电场相对应的传播子在 L1-L∞ 算子规范中具有以时间 t 和 h 的幂为单位的全局衰减率。由于亥姆霍兹分解定理的存在,对于球外部的麦克斯韦方程,一般来说,迪里夏特-拉普拉斯波算子 L1-L∞ 规范估计值不应成立。
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引用次数: 0
Stability for degenerate wave equations with drift under simultaneous degenerate damping 具有漂移的退化波方程在同步退化阻尼下的稳定性
IF 2.4 2区 数学 Q1 MATHEMATICS Pub Date : 2024-10-22 DOI: 10.1016/j.jde.2024.10.022
Mohammad Akil , Genni Fragnelli , Ibtissam Issa
In this paper we study the stability of two different problems. The first one is a one-dimensional degenerate wave equation with degenerate damping, incorporating a drift term and a leading operator in non-divergence form. In the second problem we consider a system that couples degenerate and non-degenerate wave equations, connected through transmission, and subject to a single dissipation law at the boundary of the non-degenerate equation. In both scenarios, we derive exponential stability results.
本文研究了两个不同问题的稳定性。第一个问题是一个具有退化阻尼的一维退化波方程,包含一个漂移项和一个非发散形式的前导算子。在第二个问题中,我们考虑了一个耦合退化波方程和非退化波方程的系统,该系统通过传输连接,并在非退化方程的边界受制于单一耗散定律。在这两种情况下,我们都得出了指数稳定性结果。
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引用次数: 0
The growth mechanism of boundary layers for the 2D Navier-Stokes equations 二维纳维-斯托克斯方程的边界层生长机制
IF 2.4 2区 数学 Q1 MATHEMATICS Pub Date : 2024-10-18 DOI: 10.1016/j.jde.2024.10.012
Fei Wang , Yichun Zhu
We give a detailed description of formation of the boundary layers in the inviscid limit problem. To be more specific, we prove that the magnitude of the vorticity near the boundary is growing to the size of 1/ν and the width of the layer is spreading out to be proportional the ν in a finite time period. In fact, the growth time scaling is almost ν.
我们详细描述了不粘性极限问题中边界层的形成。更具体地说,我们证明了边界附近涡度的大小在有限时间内增长到 1/ν,而层的宽度在有限时间内扩展到与ν成正比。事实上,增长时间尺度几乎为 ν。
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引用次数: 0
Asymptotic behavior for stationary Navier-Stokes equations 静态纳维-斯托克斯方程的渐近行为
IF 2.4 2区 数学 Q1 MATHEMATICS Pub Date : 2024-10-18 DOI: 10.1016/j.jde.2024.10.011
Yupei Li, Wei Luo
In this paper, we investigate the asymptotic behavior of solutions to the axisymmetric stationary Navier-Stokes equations. We assume that the flow is periodic in x3-direction and has no swirl. Under the general integrability condition, we prove the pointwise decay estimate of the vorticity ω and obtain the Liouville-type theorem.
本文研究了轴对称静止纳维-斯托克斯方程解的渐近行为。我们假设流动在 x3 方向上是周期性的,并且没有漩涡。在一般的可整性条件下,我们证明了涡度 ω 的点式衰减估计值,并得到了 Liouville 型定理。
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引用次数: 0
More limit cycles for complex differential equations with three monomials 有三个单项式的复微分方程的更多极限循环
IF 2.4 2区 数学 Q1 MATHEMATICS Pub Date : 2024-10-18 DOI: 10.1016/j.jde.2024.10.013
M.J. Álvarez , B. Coll , A. Gasull , R. Prohens
In this paper we improve, by almost doubling, the existing lower bound for the number of limit cycles of the family of complex differential equations with three monomials, z˙=Azkz¯l+Bzmz¯n+Czpz¯q, being k,l,m,n,p,q non-negative integers and A,B,CC. More concretely, if N=max(k+l,m+n,p+q) and H3(N)N{} denotes the maximum number of limit cycles of the above equations, we show that for N4, H3(N)N3 and that for some values of N this new lower bound is N+1. We also present examples with many limit cycles and different configurations. Finally, we show that H3(2)2 and study in detail the quadratic case with three monomials proving in some of them non-existence, uniqueness or existence of exactly two limit cycles.
在本文中,我们改进了复微分方程族中三个单项式 z˙=Azkz¯l+Bzmz¯n+Czpz¯q 的极限循环数的现有下界,几乎翻了一番,k,l,m,n,p,q 为非负整数,A,B,C∈C。更具体地说,如果 N=max(k+l,m+n,p+q),H3(N)∈N∪{∞} 表示上述方程的最大极限循环数,我们将证明对于 N≥4 时,H3(N)≥N-3,并且对于某些 N 值,这一新的下界是 N+1。我们还举例说明了许多极限循环和不同配置。最后,我们证明了 H3(2)≥2,并详细研究了有三个单项式的二次情况,证明了其中某些情况下两个极限循环不存在、唯一或存在。
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引用次数: 0
L1-theory for incompressible limit of reaction-diffusion porous medium flow with linear drift 具有线性漂移的反应扩散多孔介质流不可压缩极限的 L1 理论
IF 2.4 2区 数学 Q1 MATHEMATICS Pub Date : 2024-10-18 DOI: 10.1016/j.jde.2024.09.042
Noureddine Igbida
Our aim is to study existence, uniqueness and the limit, as m, of the solution of the porous medium equation with linear drift tuΔum+(uV)=g(t,x,u) in bounded domain with Dirichlet boundary condition. We treat the problem without any sign restriction on the solution with an outpointing vector field V on the boundary and a general source term g (including the continuous Lipschitz case). Under reasonably sharp Sobolev assumptions on V, we show uniform L1-convergence towards the solution of reaction-diffusion Hele-Shaw flow with linear drift.
我们的目的是研究具有线性漂移的多孔介质方程 ∂tu-Δum+∇⋅(uV)=g(t,x,u) 的解的存在性、唯一性以及 m→∞ 时的极限。我们在处理这个问题时,不对解作任何符号限制,在边界上有一个外指向向量场 V 和一个一般源项 g(包括连续 Lipschitz 情况)。在 V 的合理尖锐 Sobolev 假设下,我们展示了对具有线性漂移的反应扩散 Hele-Shaw 流解的均匀 L1 收敛性。
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引用次数: 0
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Journal of Differential Equations
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