Pub Date : 2022-05-17DOI: 10.1097/DBP.0000000000001069
R. Aishworiya, I. Magiati, D. Phua, L. M. Daniel, L. Shek, Y. Chong, P. Gluckman, M. Meaney, E. Law
This article has supplementary material on the web site: www.jdbp.org. ABSTRACT: Objective: Screen time in early childhood has been associated with children's prosocial and behavioral skills; however, the directionality of this relationship is unclear. We aimed to determine the direction of the relationship between screen time, social skills, and nonsocial behavioral traits in young children. Methods: This was a population-based, prospective cohort study with data across 5 time points. We examined the reciprocal relationships between caregiver-reported children's screen time at 12, 18, 24, 36, and 54 months and social behaviors collected using the Infant-Toddler Social-Emotional Assessment at 12 months; the Quantitative Checklist for Autism at 18, 24, and 36 months; and the Social Responsiveness Scale at 54 months. Cross-lagged path models were used for analysis. Results: A multiple imputation data set and complete data from 229 participants were included in the analyses. Screen time at 12, 18, and 36 months predicted nonsocial behavioral traits at 54 months. Cross-lagged path models showed a clear direction from increased screen time at earlier time points to both poorer social skills and atypical behaviors at later time points (Akaike information criterion 18936.55, Bayesian information criterion 19210.73, root mean square error of approximation 0.037, and comparative fit index 0.943). Social skills or behavioral traits at a younger age did not predict later screen time at any of the time points. Conclusion: Screen time in early childhood has lagged influences on social skills and nonsocial behaviors; the reverse relationship is not found. Close monitoring of social behaviors may be warranted in the setting of excessive screen time during early childhood.
{"title":"Are There Bidirectional Influences Between Screen Time Exposure and Social Behavioral Traits in Young Children?","authors":"R. Aishworiya, I. Magiati, D. Phua, L. M. Daniel, L. Shek, Y. Chong, P. Gluckman, M. Meaney, E. Law","doi":"10.1097/DBP.0000000000001069","DOIUrl":"https://doi.org/10.1097/DBP.0000000000001069","url":null,"abstract":"This article has supplementary material on the web site: www.jdbp.org. ABSTRACT: Objective: Screen time in early childhood has been associated with children's prosocial and behavioral skills; however, the directionality of this relationship is unclear. We aimed to determine the direction of the relationship between screen time, social skills, and nonsocial behavioral traits in young children. Methods: This was a population-based, prospective cohort study with data across 5 time points. We examined the reciprocal relationships between caregiver-reported children's screen time at 12, 18, 24, 36, and 54 months and social behaviors collected using the Infant-Toddler Social-Emotional Assessment at 12 months; the Quantitative Checklist for Autism at 18, 24, and 36 months; and the Social Responsiveness Scale at 54 months. Cross-lagged path models were used for analysis. Results: A multiple imputation data set and complete data from 229 participants were included in the analyses. Screen time at 12, 18, and 36 months predicted nonsocial behavioral traits at 54 months. Cross-lagged path models showed a clear direction from increased screen time at earlier time points to both poorer social skills and atypical behaviors at later time points (Akaike information criterion 18936.55, Bayesian information criterion 19210.73, root mean square error of approximation 0.037, and comparative fit index 0.943). Social skills or behavioral traits at a younger age did not predict later screen time at any of the time points. Conclusion: Screen time in early childhood has lagged influences on social skills and nonsocial behaviors; the reverse relationship is not found. Close monitoring of social behaviors may be warranted in the setting of excessive screen time during early childhood.","PeriodicalId":15655,"journal":{"name":"Journal of Developmental & Behavioral Pediatrics","volume":"2 1","pages":"362 - 369"},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87811137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-06DOI: 10.1097/DBP.0000000000001079
R. Weng, K. Nenning, M. Schwarz, K. Riedhammer, T. Brunet, M. Wagner, G. Kasprian, J. Lehrner, F. Zimprich, S. Bonelli, M. Krenn
This article has supplementary material on the web site: www.jdbp.org. ABSTRACT: Objective: Causative variants in SETD1B, encoding a lysine-specific methyltransferase, have recently been associated with a neurodevelopmental phenotype encompassing intellectual disability, autistic features, pronounced language delay, and epilepsy. It has been noted that long-term and deep phenotype data are needed to further delineate this rare condition. Methods: In this study, we provide an in-depth clinical characterization with long-term follow-up and trio exome sequencing findings to describe one additional individual affected by SETD1B-related disorder. The diagnostic workup was complemented by a functional magnetic resonance imaging (fMRI) study. Results: We report a 24-year-old male individual with an early-onset neurodevelopmental disorder with epilepsy due to the de novo missense variant c.5699A>G, p.(Tyr1900Cys) in SETD1B (NM_015048.1). He exhibited delayed speech development, autism spectrum disorder, and early-onset epilepsy with absence and generalized tonic-clonic seizures. Despite profoundly impaired communication skills, ongoing improvements regarding language production have been noted in adulthood. fMRI findings demonstrate abnormal language activation and resting-state connectivity structure. Conclusion: Our report expands the previously delineated phenotype of SETD1B-related disorder and provides novel insights into underlying disease mechanisms.
{"title":"Connectome Analysis in an Individual with SETD1B-Related Neurodevelopmental Disorder and Epilepsy","authors":"R. Weng, K. Nenning, M. Schwarz, K. Riedhammer, T. Brunet, M. Wagner, G. Kasprian, J. Lehrner, F. Zimprich, S. Bonelli, M. Krenn","doi":"10.1097/DBP.0000000000001079","DOIUrl":"https://doi.org/10.1097/DBP.0000000000001079","url":null,"abstract":"This article has supplementary material on the web site: www.jdbp.org. ABSTRACT: Objective: Causative variants in SETD1B, encoding a lysine-specific methyltransferase, have recently been associated with a neurodevelopmental phenotype encompassing intellectual disability, autistic features, pronounced language delay, and epilepsy. It has been noted that long-term and deep phenotype data are needed to further delineate this rare condition. Methods: In this study, we provide an in-depth clinical characterization with long-term follow-up and trio exome sequencing findings to describe one additional individual affected by SETD1B-related disorder. The diagnostic workup was complemented by a functional magnetic resonance imaging (fMRI) study. Results: We report a 24-year-old male individual with an early-onset neurodevelopmental disorder with epilepsy due to the de novo missense variant c.5699A>G, p.(Tyr1900Cys) in SETD1B (NM_015048.1). He exhibited delayed speech development, autism spectrum disorder, and early-onset epilepsy with absence and generalized tonic-clonic seizures. Despite profoundly impaired communication skills, ongoing improvements regarding language production have been noted in adulthood. fMRI findings demonstrate abnormal language activation and resting-state connectivity structure. Conclusion: Our report expands the previously delineated phenotype of SETD1B-related disorder and provides novel insights into underlying disease mechanisms.","PeriodicalId":15655,"journal":{"name":"Journal of Developmental & Behavioral Pediatrics","volume":"158 1","pages":"e419 - e422"},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88452208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-30DOI: 10.1097/DBP.0000000000001073
A. Harrison, M. Francesconi, E. Flouri
This article has supplementary material on the web site: www.jdbp.org. ABSTRACT: Objective: Differences in decision-making under conditions of risk have been observed cross-sectionally in clinical groups of people with eating disorders but have never been studied longitudinally or in large cohorts. We investigated whether responses on the Cambridge Gambling Task (CGT), measured in the Millennium Cohort Study in childhood, would predict prodromal eating pathology in adolescence. Method: Regression models were built to explore relationships between CGT variables at age 11 years and prodromal eating pathology (body dissatisfaction, intention to lose weight, dietary restriction, significant under/overweight, and excessive exercise) at 14 years. Results: In 11,303 boys and girls, those with better quality decision-making were 34% less likely to show an intention to lose weight (b = −0.40, odds ratio [OR] = 0.66, p < 0.05) and 34% less likely to be overweight (b = −0.41, relative risk ratio [RRR] = 0.66, p < 0.05). Those with higher risk-taking were 58% more likely to report dietary restriction (b = 0.45, OR = 1.58, p < 0.05) and 46% more likely to report excessive exercise (b = 0.38, OR = 1.46, p < 0.05). In the complete-cases sample, higher risk-adjustment scores were associated with a 47% increased risk of underweight (b = 0.39, RRR = 1.47, p < 0.05), and better quality of decision-making was associated with a 46% lower risk of overweight (b = −0.60, RRR = 0.54, p < 0.05). Conclusion: Disadvantageous decision-making in childhood may predict prodromal eating pathology in adolescence and might represent a prevention target.
本文在网站www.jdbp.org上有补充资料。摘要:目的:在饮食失调患者的临床组中，已经观察到风险条件下决策的差异，但从未进行过纵向或大型队列研究。我们调查了剑桥赌博任务(CGT)的反应，在儿童千年队列研究中测量，是否会预测青春期的前驱饮食病理。方法:建立回归模型，探讨11岁时CGT变量与14岁时前驱饮食病理(身体不满意、减肥意图、饮食限制、明显不足/超重和过度运动)之间的关系。结果:在11,303名男孩和女孩中，决策质量较好的男孩和女孩表现出减肥意图的可能性降低34% (b = - 0.40，优势比[OR] = 0.66, p < 0.05)，超重的可能性降低34% (b = - 0.41，相对风险比[RRR] = 0.66, p < 0.05)。风险较高的人报告饮食限制的可能性高58% (b = 0.45, OR = 1.58, p < 0.05)，报告过度运动的可能性高46% (b = 0.38, OR = 1.46, p < 0.05)。在完整病例样本中，较高的风险调整得分与体重不足风险增加47%相关(b = 0.39, RRR = 1.47, p < 0.05)，较好的决策质量与超重风险降低46%相关(b = - 0.60, RRR = 0.54, p < 0.05)。结论:儿童期的不良决策可以预测青春期的前驱进食病理，可能是预防的目标。
{"title":"Decision-Making in Childhood Predicts Prodromal Eating Pathology in Adolescence","authors":"A. Harrison, M. Francesconi, E. Flouri","doi":"10.1097/DBP.0000000000001073","DOIUrl":"https://doi.org/10.1097/DBP.0000000000001073","url":null,"abstract":"This article has supplementary material on the web site: www.jdbp.org. ABSTRACT: Objective: Differences in decision-making under conditions of risk have been observed cross-sectionally in clinical groups of people with eating disorders but have never been studied longitudinally or in large cohorts. We investigated whether responses on the Cambridge Gambling Task (CGT), measured in the Millennium Cohort Study in childhood, would predict prodromal eating pathology in adolescence. Method: Regression models were built to explore relationships between CGT variables at age 11 years and prodromal eating pathology (body dissatisfaction, intention to lose weight, dietary restriction, significant under/overweight, and excessive exercise) at 14 years. Results: In 11,303 boys and girls, those with better quality decision-making were 34% less likely to show an intention to lose weight (b = −0.40, odds ratio [OR] = 0.66, p < 0.05) and 34% less likely to be overweight (b = −0.41, relative risk ratio [RRR] = 0.66, p < 0.05). Those with higher risk-taking were 58% more likely to report dietary restriction (b = 0.45, OR = 1.58, p < 0.05) and 46% more likely to report excessive exercise (b = 0.38, OR = 1.46, p < 0.05). In the complete-cases sample, higher risk-adjustment scores were associated with a 47% increased risk of underweight (b = 0.39, RRR = 1.47, p < 0.05), and better quality of decision-making was associated with a 46% lower risk of overweight (b = −0.60, RRR = 0.54, p < 0.05). Conclusion: Disadvantageous decision-making in childhood may predict prodromal eating pathology in adolescence and might represent a prevention target.","PeriodicalId":15655,"journal":{"name":"Journal of Developmental & Behavioral Pediatrics","volume":"7 1","pages":"e407 - e413"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82525972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-10DOI: 10.1097/dbp.0000000000000811
Cassandra Conrad, Elizabeth B. Harstad
activity and exercise training in the United States. Prog Cardiovasc Dis. 2017;60:3–10. 32. Centers for Disease Control and Prevention. Data and Statistics: Sleep and Sleep Disorders. 2019. Available at: https://www.cdc. gov/sleep/data_statistics.html. Accessed June 19, 2019. 33. Adams SA. The effect of social desirability and social approval on selfreports of physical activity. Am J Epidemiol. 2005;161:389–398. 34. Myers RJ, Klesges RC, Eck LH, et al. Accuracy of self-reports of food intake in obese and normal-weight individuals: effects of obesity on self-reports of dietary intake in adult females. Am J Clin Nutr. 1988; 48:1248–1251.
{"title":"Children and Youth with Complex Cerebral Palsy: Care and Management.","authors":"Cassandra Conrad, Elizabeth B. Harstad","doi":"10.1097/dbp.0000000000000811","DOIUrl":"https://doi.org/10.1097/dbp.0000000000000811","url":null,"abstract":"activity and exercise training in the United States. Prog Cardiovasc Dis. 2017;60:3–10. 32. Centers for Disease Control and Prevention. Data and Statistics: Sleep and Sleep Disorders. 2019. Available at: https://www.cdc. gov/sleep/data_statistics.html. Accessed June 19, 2019. 33. Adams SA. The effect of social desirability and social approval on selfreports of physical activity. Am J Epidemiol. 2005;161:389–398. 34. Myers RJ, Klesges RC, Eck LH, et al. Accuracy of self-reports of food intake in obese and normal-weight individuals: effects of obesity on self-reports of dietary intake in adult females. Am J Clin Nutr. 1988; 48:1248–1251.","PeriodicalId":15655,"journal":{"name":"Journal of Developmental & Behavioral Pediatrics","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75437145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.1097/dbp.0000000000000805
L. Grossman
{"title":"The Grandfamily Guidebook: Wisdom and Support for Grandparents Raising Grandchildren.","authors":"L. Grossman","doi":"10.1097/dbp.0000000000000805","DOIUrl":"https://doi.org/10.1097/dbp.0000000000000805","url":null,"abstract":"","PeriodicalId":15655,"journal":{"name":"Journal of Developmental & Behavioral Pediatrics","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80678376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-01DOI: 10.1097/DBP.0000000000000755
Katrina M Poppert Cordts, A. Wilson, Andrew R. Riley
OBJECTIVE Caring for young children is a physically demanding task, and some evidence suggests parental physical limitations may impact the parent-child relationship and child behavioral development, but research examining this dynamic is nascent. METHODS This study aims to explicate the role of general parent physical health problems in child disruptive behavior outcomes. A model that included physical and mental health, parenting style and self-efficacy, and child behavior symptom ratings was derived. The tenability of the model was assessed using Pearson's correlations, followed by structural equation modeling using data from 375 parents with a child between 18 months and 5 years. RESULTS After several modifications to the initial model, findings revealed that higher levels of parent self-reported physical and mental health concerns indirectly influence child behavior symptoms through different pathways. Impaired parent physical health was associated with poorer parental self-efficacy and more disruptive child behavior, whereas increased parent mental health concerns were associated with a more negative parenting style and lower self-efficacy, which was related to more child behavior symptoms. CONCLUSION Findings elucidate the need for increased awareness and screening of parent physical health limitations in pediatric primary care. Furthermore, appropriate interventions among parents with physical health problems may target different aspects of parenting than routinely discussed.
{"title":"More than Mental Health: Parent Physical Health and Early Childhood Behavior Problems.","authors":"Katrina M Poppert Cordts, A. Wilson, Andrew R. Riley","doi":"10.1097/DBP.0000000000000755","DOIUrl":"https://doi.org/10.1097/DBP.0000000000000755","url":null,"abstract":"OBJECTIVE\u0000Caring for young children is a physically demanding task, and some evidence suggests parental physical limitations may impact the parent-child relationship and child behavioral development, but research examining this dynamic is nascent.\u0000\u0000\u0000METHODS\u0000This study aims to explicate the role of general parent physical health problems in child disruptive behavior outcomes. A model that included physical and mental health, parenting style and self-efficacy, and child behavior symptom ratings was derived. The tenability of the model was assessed using Pearson's correlations, followed by structural equation modeling using data from 375 parents with a child between 18 months and 5 years.\u0000\u0000\u0000RESULTS\u0000After several modifications to the initial model, findings revealed that higher levels of parent self-reported physical and mental health concerns indirectly influence child behavior symptoms through different pathways. Impaired parent physical health was associated with poorer parental self-efficacy and more disruptive child behavior, whereas increased parent mental health concerns were associated with a more negative parenting style and lower self-efficacy, which was related to more child behavior symptoms.\u0000\u0000\u0000CONCLUSION\u0000Findings elucidate the need for increased awareness and screening of parent physical health limitations in pediatric primary care. Furthermore, appropriate interventions among parents with physical health problems may target different aspects of parenting than routinely discussed.","PeriodicalId":15655,"journal":{"name":"Journal of Developmental & Behavioral Pediatrics","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86161392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1097/DBP.0000000000000793
S. Dubner, Julie Youssef
social scenes in 6-month-old infants later diagnosed with autism spectrum disorders. Biol Psychiatry. 2013;74:195–203. 30. Boyd BA, Baranek GT, Sideris J, et al. Sensory features and repetitive behaviors in children with autism and developmental delays. Autism Res. 2010;3:78–87. 31. Anderson PJ, Reidy N. Assessing executive function in preschoolers. Neuropsychol Rev. 2012;22:345– 360. 32. Orinstein AJ, Helt M, Troyb E, et al. Intervention for optimal outcome in children and adolescents with a history of autism. J Dev Behav Pediatr. 2014;35:247–256.
6个月大的婴儿的社交场景后来被诊断为自闭症谱系障碍。中华精神病学杂志。2013;44(4):391 - 391。30.Boyd BA, Baranek GT, Sideris J，等。自闭症和发育迟缓儿童的感觉特征和重复行为。孤独症研究。2010;3:78-87。31. 学前儿童执行功能的评估。神经心理学，2012;22:345 - 360。32. Orinstein AJ, Helt M, Troyb E，等。干预对有自闭症史的儿童和青少年的最佳结果。[J] .中华儿科杂志，2014;35(5):347 - 356。
{"title":"Trauma, Autism, and Neurodevelopmental Disorders: Integrating Research, Practice, and Policy","authors":"S. Dubner, Julie Youssef","doi":"10.1097/DBP.0000000000000793","DOIUrl":"https://doi.org/10.1097/DBP.0000000000000793","url":null,"abstract":"social scenes in 6-month-old infants later diagnosed with autism spectrum disorders. Biol Psychiatry. 2013;74:195–203. 30. Boyd BA, Baranek GT, Sideris J, et al. Sensory features and repetitive behaviors in children with autism and developmental delays. Autism Res. 2010;3:78–87. 31. Anderson PJ, Reidy N. Assessing executive function in preschoolers. Neuropsychol Rev. 2012;22:345– 360. 32. Orinstein AJ, Helt M, Troyb E, et al. Intervention for optimal outcome in children and adolescents with a history of autism. J Dev Behav Pediatr. 2014;35:247–256.","PeriodicalId":15655,"journal":{"name":"Journal of Developmental & Behavioral Pediatrics","volume":"198 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91552606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1097/DBP.0000000000000745
Taralee Hamner, S. Hepburn, F. Zhang, D. Fidler, Cordelia Robinson Rosenberg, D. Robins, N. Lee
OBJECTIVE The prevalence of comorbid autism spectrum disorder (ASD) in children with Down syndrome (DS) is estimated to be around 16%. This study aims to fill gaps in the literature by describing developmental and behavioral phenotypes in this group relative to those with DS or ASD in isolation. METHODS Participants included 173 children (Mage = 73 months) with ASD, DS, or DS + ASD. Two 3 × 2 repeated-measures analyses of variance were completed with between-subject factors of the diagnostic group (DS, ASD, and DS + ASD) and within-subject factors of cognitive performance (verbal and nonverbal developmental quotient [DQ]) or ASD symptoms (social affect [SA] and restricted and repetitive behaviors [RRBs]). RESULTS Significant group-by-scale interactions were found, and pairwise comparisons revealed that for verbal DQ, DS + ASD < DS, ASD, whereas for nonverbal DQ, DS + ASD < DS < ASD. For SA, DS < DS + ASD < ASD, whereas for RRB, DS, DS + ASD < ASD. CONCLUSION Findings suggest greater cognitive impairment in DS + ASD on both verbal and nonverbal measures. Despite these significant cognitive challenges, ASD symptoms appeared less severe in DS + ASD relative to peers with ASD in isolation, although SA symptoms were elevated over DS-only. This unique DS + ASD presentation has important implications for early identification and intervention. Given previous research suggesting relative social strengths in DS and less severe ASD symptoms documented in this study, future research may benefit from investigating different aspects of SA (i.e., components related to reciprocal social interaction vs. social communication) in those with DS + ASD to more clearly delineate the social phenotype in this group and potentially inform intervention efforts.
{"title":"Cognitive Profiles and Autism Symptoms in Comorbid Down Syndrome and Autism Spectrum Disorder.","authors":"Taralee Hamner, S. Hepburn, F. Zhang, D. Fidler, Cordelia Robinson Rosenberg, D. Robins, N. Lee","doi":"10.1097/DBP.0000000000000745","DOIUrl":"https://doi.org/10.1097/DBP.0000000000000745","url":null,"abstract":"OBJECTIVE\u0000The prevalence of comorbid autism spectrum disorder (ASD) in children with Down syndrome (DS) is estimated to be around 16%. This study aims to fill gaps in the literature by describing developmental and behavioral phenotypes in this group relative to those with DS or ASD in isolation.\u0000\u0000\u0000METHODS\u0000Participants included 173 children (Mage = 73 months) with ASD, DS, or DS + ASD. Two 3 × 2 repeated-measures analyses of variance were completed with between-subject factors of the diagnostic group (DS, ASD, and DS + ASD) and within-subject factors of cognitive performance (verbal and nonverbal developmental quotient [DQ]) or ASD symptoms (social affect [SA] and restricted and repetitive behaviors [RRBs]).\u0000\u0000\u0000RESULTS\u0000Significant group-by-scale interactions were found, and pairwise comparisons revealed that for verbal DQ, DS + ASD < DS, ASD, whereas for nonverbal DQ, DS + ASD < DS < ASD. For SA, DS < DS + ASD < ASD, whereas for RRB, DS, DS + ASD < ASD.\u0000\u0000\u0000CONCLUSION\u0000Findings suggest greater cognitive impairment in DS + ASD on both verbal and nonverbal measures. Despite these significant cognitive challenges, ASD symptoms appeared less severe in DS + ASD relative to peers with ASD in isolation, although SA symptoms were elevated over DS-only. This unique DS + ASD presentation has important implications for early identification and intervention. Given previous research suggesting relative social strengths in DS and less severe ASD symptoms documented in this study, future research may benefit from investigating different aspects of SA (i.e., components related to reciprocal social interaction vs. social communication) in those with DS + ASD to more clearly delineate the social phenotype in this group and potentially inform intervention efforts.","PeriodicalId":15655,"journal":{"name":"Journal of Developmental & Behavioral Pediatrics","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78482912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1097/DBP.0000000000000774
Rene Bartos, Y. Yatchmink
{"title":"Thinking Developmentally: Nurturing Wellness in Childhood to Promote Lifelong Health","authors":"Rene Bartos, Y. Yatchmink","doi":"10.1097/DBP.0000000000000774","DOIUrl":"https://doi.org/10.1097/DBP.0000000000000774","url":null,"abstract":"","PeriodicalId":15655,"journal":{"name":"Journal of Developmental & Behavioral Pediatrics","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86161847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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