Journal of Developmental & Behavioral Pediatrics最新文献

英文中文

Are There Bidirectional Influences Between Screen Time Exposure and Social Behavioral Traits in Young Children? 幼儿屏幕时间暴露与社会行为特征是否存在双向影响?

Journal of Developmental & Behavioral Pediatrics

Pub Date : 2022-05-17 DOI: 10.1097/DBP.0000000000001069

R. Aishworiya, I. Magiati, D. Phua, L. M. Daniel, L. Shek, Y. Chong, P. Gluckman, M. Meaney, E. Law

This article has supplementary material on the web site: www.jdbp.org. ABSTRACT: Objective: Screen time in early childhood has been associated with children's prosocial and behavioral skills; however, the directionality of this relationship is unclear. We aimed to determine the direction of the relationship between screen time, social skills, and nonsocial behavioral traits in young children. Methods: This was a population-based, prospective cohort study with data across 5 time points. We examined the reciprocal relationships between caregiver-reported children's screen time at 12, 18, 24, 36, and 54 months and social behaviors collected using the Infant-Toddler Social-Emotional Assessment at 12 months; the Quantitative Checklist for Autism at 18, 24, and 36 months; and the Social Responsiveness Scale at 54 months. Cross-lagged path models were used for analysis. Results: A multiple imputation data set and complete data from 229 participants were included in the analyses. Screen time at 12, 18, and 36 months predicted nonsocial behavioral traits at 54 months. Cross-lagged path models showed a clear direction from increased screen time at earlier time points to both poorer social skills and atypical behaviors at later time points (Akaike information criterion 18936.55, Bayesian information criterion 19210.73, root mean square error of approximation 0.037, and comparative fit index 0.943). Social skills or behavioral traits at a younger age did not predict later screen time at any of the time points. Conclusion: Screen time in early childhood has lagged influences on social skills and nonsocial behaviors; the reverse relationship is not found. Close monitoring of social behaviors may be warranted in the setting of excessive screen time during early childhood.

本文在网站www.jdbp.org上有补充资料。摘要:目的:儿童早期屏幕时间与儿童亲社会技能和行为技能的关系;然而，这种关系的方向性尚不清楚。我们的目的是确定幼儿看屏幕时间、社交技能和非社会行为特征之间关系的方向。方法:这是一项基于人群的前瞻性队列研究，数据跨越5个时间点。我们研究了照顾者报告的儿童在12、18、24、36和54个月时的屏幕时间与12个月时使用婴幼儿社会情绪评估收集的社会行为之间的相互关系;18、24、36个月自闭症定量检查表;以及54个月时的社会反应量表。交叉滞后路径模型用于分析。结果:纳入了229名参与者的多重输入数据集和完整数据。12个月、18个月和36个月的屏幕时间预测了54个月时的非社会行为特征。交叉滞后路径模型显示，从较早时间点屏幕时间增加到较晚时间点社交技能和非典型行为较差的方向明显(赤池信息准则18936.55，贝叶斯信息准则19210.73，均方根误差近似为0.037，比较拟合指数0.943)。在任何时间点上，年轻时的社交技能或行为特征都不能预测以后的屏幕时间。结论:儿童早期屏幕时间对社会技能和非社会行为有滞后影响;没有发现相反的关系。在儿童早期过度使用屏幕的情况下，可能需要密切监测社会行为。

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引用次数: 4

Connectome Analysis in an Individual with SETD1B-Related Neurodevelopmental Disorder and Epilepsy setd1b相关神经发育障碍和癫痫患者的连接组分析

Journal of Developmental & Behavioral Pediatrics

Pub Date : 2022-04-06 DOI: 10.1097/DBP.0000000000001079

R. Weng, K. Nenning, M. Schwarz, K. Riedhammer, T. Brunet, M. Wagner, G. Kasprian, J. Lehrner, F. Zimprich, S. Bonelli, M. Krenn

This article has supplementary material on the web site: www.jdbp.org. ABSTRACT: Objective: Causative variants in SETD1B, encoding a lysine-specific methyltransferase, have recently been associated with a neurodevelopmental phenotype encompassing intellectual disability, autistic features, pronounced language delay, and epilepsy. It has been noted that long-term and deep phenotype data are needed to further delineate this rare condition. Methods: In this study, we provide an in-depth clinical characterization with long-term follow-up and trio exome sequencing findings to describe one additional individual affected by SETD1B-related disorder. The diagnostic workup was complemented by a functional magnetic resonance imaging (fMRI) study. Results: We report a 24-year-old male individual with an early-onset neurodevelopmental disorder with epilepsy due to the de novo missense variant c.5699A>G, p.(Tyr1900Cys) in SETD1B (NM_015048.1). He exhibited delayed speech development, autism spectrum disorder, and early-onset epilepsy with absence and generalized tonic-clonic seizures. Despite profoundly impaired communication skills, ongoing improvements regarding language production have been noted in adulthood. fMRI findings demonstrate abnormal language activation and resting-state connectivity structure. Conclusion: Our report expands the previously delineated phenotype of SETD1B-related disorder and provides novel insights into underlying disease mechanisms.

本文在网站www.jdbp.org上有补充资料。摘要:目的:最近研究发现，编码赖氨酸特异性甲基转移酶的SETD1B致病变异与一种神经发育表型相关，包括智力残疾、自闭症特征、明显的语言迟缓和癫痫。值得注意的是，需要长期和深入的表型数据来进一步描述这种罕见的疾病。方法:在这项研究中，我们通过长期随访和三外显子组测序结果提供了深入的临床特征，以描述另一个受setd1b相关疾病影响的个体。诊断工作由功能性磁共振成像(fMRI)研究补充。结果:我们报告了一名24岁男性患者，由于SETD1B (NM_015048.1)中新生错义变异c.5699A>G, p.(Tyr1900Cys)而导致早发性神经发育障碍伴癫痫。他表现出语言发育迟缓，自闭症谱系障碍，早发性癫痫缺失和全身性强直阵挛发作。尽管沟通能力严重受损，但在成年期，语言表达能力仍在不断提高。fMRI结果显示语言激活和静息状态连接结构异常。结论:我们的报告扩展了先前描述的setd1b相关疾病的表型，并为潜在的疾病机制提供了新的见解。

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引用次数: 2

Decision-Making in Childhood Predicts Prodromal Eating Pathology in Adolescence 儿童期的决策可以预测青春期的前驱饮食病理

Journal of Developmental & Behavioral Pediatrics

Pub Date : 2022-03-30 DOI: 10.1097/DBP.0000000000001073

A. Harrison, M. Francesconi, E. Flouri

This article has supplementary material on the web site: www.jdbp.org. ABSTRACT: Objective: Differences in decision-making under conditions of risk have been observed cross-sectionally in clinical groups of people with eating disorders but have never been studied longitudinally or in large cohorts. We investigated whether responses on the Cambridge Gambling Task (CGT), measured in the Millennium Cohort Study in childhood, would predict prodromal eating pathology in adolescence. Method: Regression models were built to explore relationships between CGT variables at age 11 years and prodromal eating pathology (body dissatisfaction, intention to lose weight, dietary restriction, significant under/overweight, and excessive exercise) at 14 years. Results: In 11,303 boys and girls, those with better quality decision-making were 34% less likely to show an intention to lose weight (b = −0.40, odds ratio [OR] = 0.66, p < 0.05) and 34% less likely to be overweight (b = −0.41, relative risk ratio [RRR] = 0.66, p < 0.05). Those with higher risk-taking were 58% more likely to report dietary restriction (b = 0.45, OR = 1.58, p < 0.05) and 46% more likely to report excessive exercise (b = 0.38, OR = 1.46, p < 0.05). In the complete-cases sample, higher risk-adjustment scores were associated with a 47% increased risk of underweight (b = 0.39, RRR = 1.47, p < 0.05), and better quality of decision-making was associated with a 46% lower risk of overweight (b = −0.60, RRR = 0.54, p < 0.05). Conclusion: Disadvantageous decision-making in childhood may predict prodromal eating pathology in adolescence and might represent a prevention target.

本文在网站www.jdbp.org上有补充资料。摘要:目的:在饮食失调患者的临床组中，已经观察到风险条件下决策的差异，但从未进行过纵向或大型队列研究。我们调查了剑桥赌博任务(CGT)的反应，在儿童千年队列研究中测量，是否会预测青春期的前驱饮食病理。方法:建立回归模型，探讨11岁时CGT变量与14岁时前驱饮食病理(身体不满意、减肥意图、饮食限制、明显不足/超重和过度运动)之间的关系。结果:在11,303名男孩和女孩中，决策质量较好的男孩和女孩表现出减肥意图的可能性降低34% (b = - 0.40，优势比[OR] = 0.66, p < 0.05)，超重的可能性降低34% (b = - 0.41，相对风险比[RRR] = 0.66, p < 0.05)。风险较高的人报告饮食限制的可能性高58% (b = 0.45, OR = 1.58, p < 0.05)，报告过度运动的可能性高46% (b = 0.38, OR = 1.46, p < 0.05)。在完整病例样本中，较高的风险调整得分与体重不足风险增加47%相关(b = 0.39, RRR = 1.47, p < 0.05)，较好的决策质量与超重风险降低46%相关(b = - 0.60, RRR = 0.54, p < 0.05)。结论:儿童期的不良决策可以预测青春期的前驱进食病理，可能是预防的目标。

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引用次数: 2

Children and Youth with Complex Cerebral Palsy: Care and Management. 儿童和青少年复杂脑瘫:护理和管理。

Journal of Developmental & Behavioral Pediatrics

Pub Date : 2020-06-10 DOI: 10.1097/dbp.0000000000000811

Cassandra Conrad, Elizabeth B. Harstad

activity and exercise training in the United States. Prog Cardiovasc Dis. 2017;60:3–10. 32. Centers for Disease Control and Prevention. Data and Statistics: Sleep and Sleep Disorders. 2019. Available at: https://www.cdc. gov/sleep/data_statistics.html. Accessed June 19, 2019. 33. Adams SA. The effect of social desirability and social approval on selfreports of physical activity. Am J Epidemiol. 2005;161:389–398. 34. Myers RJ, Klesges RC, Eck LH, et al. Accuracy of self-reports of food intake in obese and normal-weight individuals: effects of obesity on self-reports of dietary intake in adult females. Am J Clin Nutr. 1988; 48:1248–1251.

活动和运动训练。中华心血管病杂志，2017;60:3-10。32. 疾病控制和预防中心。数据与统计:睡眠与睡眠障碍。2019。可在:https://www.cdc。gov /睡眠/ data_statistics.html。于2019年6月19日发布。33. 亚当斯SA。社会期望和社会认可对体育活动自我报告的影响。中华流行病学杂志，2005;31(1):389 - 398。34. 杨建军，李建军，李建军，等。肥胖和正常体重个体食物摄入自我报告的准确性:肥胖对成年女性饮食摄入自我报告的影响J·J·克林·努尔;1988;48:1248 - 1251。

引用次数: 0

The Grandfamily Guidebook: Wisdom and Support for Grandparents Raising Grandchildren. 《祖父母指南:祖父母养育孙子的智慧与支持》。

Journal of Developmental & Behavioral Pediatrics

Pub Date : 2020-06-01 DOI: 10.1097/dbp.0000000000000805

L. Grossman

引用次数: 0

More than Mental Health: Parent Physical Health and Early Childhood Behavior Problems. 不仅仅是心理健康:父母身体健康和儿童早期行为问题。

Journal of Developmental & Behavioral Pediatrics

Pub Date : 2020-05-01 DOI: 10.1097/DBP.0000000000000755

Katrina M Poppert Cordts, A. Wilson, Andrew R. Riley

OBJECTIVECaring for young children is a physically demanding task, and some evidence suggests parental physical limitations may impact the parent-child relationship and child behavioral development, but research examining this dynamic is nascent.METHODSThis study aims to explicate the role of general parent physical health problems in child disruptive behavior outcomes. A model that included physical and mental health, parenting style and self-efficacy, and child behavior symptom ratings was derived. The tenability of the model was assessed using Pearson's correlations, followed by structural equation modeling using data from 375 parents with a child between 18 months and 5 years.RESULTSAfter several modifications to the initial model, findings revealed that higher levels of parent self-reported physical and mental health concerns indirectly influence child behavior symptoms through different pathways. Impaired parent physical health was associated with poorer parental self-efficacy and more disruptive child behavior, whereas increased parent mental health concerns were associated with a more negative parenting style and lower self-efficacy, which was related to more child behavior symptoms.CONCLUSIONFindings elucidate the need for increased awareness and screening of parent physical health limitations in pediatric primary care. Furthermore, appropriate interventions among parents with physical health problems may target different aspects of parenting than routinely discussed.

目的:照顾幼儿是一项对身体要求很高的任务，一些证据表明，父母身体上的限制可能会影响亲子关系和儿童行为的发展，但对这种动态的研究尚处于起步阶段。方法本研究旨在探讨一般父母身体健康问题在儿童破坏性行为结果中的作用。得出了一个包括身心健康、父母教养方式和自我效能以及儿童行为症状评分的模型。模型的可行性通过Pearson’s correlation进行评估，然后利用375对有18个月到5岁孩子的父母的数据进行结构方程建模。结果在对初始模型进行多次修改后，研究结果显示，较高水平的父母自我报告的身心健康问题通过不同途径间接影响儿童的行为症状。父母身体健康受损与较差的父母自我效能感和更多的破坏性儿童行为有关，而父母心理健康担忧增加与更消极的养育方式和较低的自我效能感有关，这与更多的儿童行为症状有关。结论:在儿科初级保健中，有必要提高对父母身体健康限制的认识和筛查。此外，有身体健康问题的父母之间的适当干预可能针对不同的方面，而不是常规讨论。

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引用次数: 8

Child-Adult Relationship Enhancement in Primary Care: A Randomized Trial of a Skill-Based Parent Training with Parent Mentor Adaptation. 在初级保健中增强儿童与成人的关系：基于技能的家长培训与家长导师适应性的随机试验》（Randomized Trial of a Skill-Based Parent Training with Parent Mentor Adaptation）。

Journal of Developmental & Behavioral Pediatrics

Pub Date : 2020-05-01 DOI: 10.1097/DBP.0000000000000759

Samantha Schilling, Victor Ritter, Joanne N Wood, Jason Fine, Adam J Zolotor

Introduction: Child-Adult Relationship Enhancement in Primary Care (PriCARE) is a 6-session group training designed to teach positive parenting skills. Parent engagement in such programs is a common implementation barrier. Our objectives were to (1) examine the impact of a peer mentor on attendance and stigma and (2) replicate a previous study by measuring PriCARE's impact on child behavior and parenting practices.

Method: Parents of 2- to -6-year-old children without specific behavior problems were randomized to mentored PriCARE (n = 50), PriCARE (n = 50), or control (n = 50). Stigma was measured at 10 weeks. Child behavior and parenting practices were measured at baseline and 10 weeks using the Eyberg Child Behavior Inventory (ECBI) and Parenting Scale (PS). Analysis of variance models were used to examine differences across groups.

Results: There was no significant difference in attendance between mentored PriCARE and PriCARE arms (mean 3.80 vs 3.36 sessions, p = 0.35). Parents randomized to the mentor reported lower stigma (3.75 vs 5.04, p = 0.02). Decreases in the mean ECBI scores between 0 and 10 weeks were greater in the PriCARE arms (n = 100) compared with the control arm (n = 50), reflecting larger improvements in behavior [intensity: -7 (-2 to -13) vs 4 (-3 to 12) to p = 0.014; problem: -3 (-1 to -4) vs 1 (-1 to 3) to p = 0.007]. Scores on all PS subscales reflected greater improvements in parenting behaviors in PriCARE arms compared with control (all p < 0.04).

Conclusion: Adapting PriCARE with a peer mentor may decrease stigma but does not improve program attendance. PriCARE shows promise in improving behavior in preschool-aged children and increasing positive parenting practices.

简介初级保健中的儿童与成人关系强化项目（PriCARE）是一项为期六节的小组培训，旨在传授积极的育儿技巧。家长参与此类项目是实施过程中常见的障碍。我们的目标是：(1) 研究同伴导师对出席率和耻辱感的影响；(2) 通过测量 PriCARE 对儿童行为和养育实践的影响，复制之前的一项研究：方法：将没有特殊行为问题的 2-6 岁儿童的家长随机分为接受 PriCARE 辅导的家长（50 人）、接受 PriCARE 辅导的家长（50 人）或对照组家长（50 人）。耻辱感在 10 周时进行测量。在基线和 10 周时，使用艾伯格儿童行为量表 (ECBI) 和养育量表 (PS) 对儿童行为和养育方式进行测量。采用方差分析模型来研究各组之间的差异：结果：接受指导的 PriCARE 和 PriCARE 两组在出席率方面没有明显差异（平均 3.80 次与 3.36 次，P = 0.35）。随机接受指导的家长的耻辱感较低（3.75 vs 5.04，p = 0.02）。与对照组（50 人）相比，PriCARE 治疗组（100 人）在 0 至 10 周期间的 ECBI 平均得分下降幅度更大，反映出行为改善幅度更大[强度：-7（-2 至 -13） vs 4（-3 至 12），p = 0.014；问题：-3（-1 至 -4） vs 1（-1 至 3），p = 0.007]。与对照组相比，PriCARE 观察组在所有 PS 分量表上的得分都反映出育儿行为有了更大的改善（所有 p <0.04）：结论：在 PriCARE 中加入同伴导师可减少耻辱感，但并不能提高项目的参与率。PriCARE 有望改善学龄前儿童的行为，并增加积极的育儿实践。

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引用次数: 0

Journal Article Reviews: Erratum. 期刊文章评论:勘误。

Journal of Developmental & Behavioral Pediatrics

Pub Date : 2020-05-01 DOI: 10.1097/DBP.0000000000000819

引用次数: 0

Onset, Trajectory, and Pattern of Feeding Difficulties in Toddlers Later Diagnosed with Autism. 后来被诊断为自闭症的学步儿童喂养困难的发生、轨迹和模式。

Journal of Developmental & Behavioral Pediatrics

Pub Date : 2020-04-01 DOI: 10.1097/DBP.0000000000000757

Kevin Ashley, Mary Beth Steinfeld, Gregory S Young, Sally Ozonoff

Objective: To examine the emergence and trajectory of feeding difficulties in young children who are later diagnosed with autism spectrum disorder (ASD).

Methods: The Behavioral Pediatrics Feeding Assessment Scale (BPFAS) was administered to a sample of 93 toddlers with an older sibling with ASD-the high-risk group-and 62 toddlers with no known familial ASD-the low-risk group-as part of a larger infant sibling study. The BPFAS was completed by parents at 15, 18, 24, and 36 months of age. At 36 months, participants underwent a diagnostic assessment and were classified into 1 of the following 4 outcome groups: ASD, nontypical development, high-risk typically developing, and low-risk typically developing. The BPFAS was scored for total frequency of feeding difficulties and autism-specific factor scores previously described in the literature.

Results: The frequency of feeding difficulties increased significantly more rapidly in the ASD group between 15 and 36 months of age, and by 36 months, they exhibited a significantly higher total frequency score than all other groups. Analysis of the factor scores revealed a similar pattern for the food acceptance and mealtime behavior domains but no significant differences in the medical/oral motor domain.

Conclusion: Feeding difficulties develop significantly more rapidly in children with ASD, with longitudinal monitoring revealing the steeper trajectory earlier than can be detected with cross-sectional analysis. Children with ASD are at risk of health and social consequences of poor feeding behavior that may potentially be minimized if addressed early and appropriately.

目的研究后来被诊断为自闭症谱系障碍（ASD）的幼儿出现喂养困难的情况和轨迹：行为儿科喂养评估量表（BPFAS）是一项大型婴儿兄弟姐妹研究的一部分，对93名有一个患有自闭症谱系障碍的哥哥姐姐的幼儿（高风险组）和62名没有已知家族性自闭症谱系障碍的幼儿（低风险组）进行抽样调查。BPFAS由父母在孩子15、18、24和36个月大时完成。36 个月大时，参与者接受诊断评估，并被分为以下 4 个结果组中的 1 个：ASD、非典型发育、高风险典型发育和低风险典型发育。BPFAS 对喂养困难的总频率和文献中描述的自闭症特异性因子进行评分：结果：在 15 到 36 个月大期间，自闭症患儿的喂养困难频率明显增加得更快，到 36 个月大时，他们的喂养困难频率总分明显高于其他所有组别。因子得分分析表明，在食物接受和进餐行为领域存在类似的模式，但在医疗/口腔运动领域没有显著差异：结论：喂养困难在 ASD 儿童中的发展速度明显更快，纵向监测比横向分析更早地揭示出陡峭的发展轨迹。患有 ASD 的儿童面临着不良喂养行为对健康和社会造成影响的风险，如果能及早、适当地解决这些问题，就有可能将其影响降至最低。

{"title":"Onset, Trajectory, and Pattern of Feeding Difficulties in Toddlers Later Diagnosed with Autism.","authors":"Kevin Ashley, Mary Beth Steinfeld, Gregory S Young, Sally Ozonoff","doi":"10.1097/DBP.0000000000000757","DOIUrl":"10.1097/DBP.0000000000000757","url":null,"abstract":"Objective: To examine the emergence and trajectory of feeding difficulties in young children who are later diagnosed with autism spectrum disorder (ASD).Methods: The Behavioral Pediatrics Feeding Assessment Scale (BPFAS) was administered to a sample of 93 toddlers with an older sibling with ASD-the high-risk group-and 62 toddlers with no known familial ASD-the low-risk group-as part of a larger infant sibling study. The BPFAS was completed by parents at 15, 18, 24, and 36 months of age. At 36 months, participants underwent a diagnostic assessment and were classified into 1 of the following 4 outcome groups: ASD, nontypical development, high-risk typically developing, and low-risk typically developing. The BPFAS was scored for total frequency of feeding difficulties and autism-specific factor scores previously described in the literature.Results: The frequency of feeding difficulties increased significantly more rapidly in the ASD group between 15 and 36 months of age, and by 36 months, they exhibited a significantly higher total frequency score than all other groups. Analysis of the factor scores revealed a similar pattern for the food acceptance and mealtime behavior domains but no significant differences in the medical/oral motor domain.Conclusion: Feeding difficulties develop significantly more rapidly in children with ASD, with longitudinal monitoring revealing the steeper trajectory earlier than can be detected with cross-sectional analysis. Children with ASD are at risk of health and social consequences of poor feeding behavior that may potentially be minimized if addressed early and appropriately.","PeriodicalId":15655,"journal":{"name":"Journal of Developmental & Behavioral Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79741237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trauma, Autism, and Neurodevelopmental Disorders: Integrating Research, Practice, and Policy 创伤、自闭症和神经发育障碍:整合研究、实践和政策

Journal of Developmental & Behavioral Pediatrics

Pub Date : 2020-04-01 DOI: 10.1097/DBP.0000000000000793

S. Dubner, Julie Youssef

social scenes in 6-month-old infants later diagnosed with autism spectrum disorders. Biol Psychiatry. 2013;74:195–203. 30. Boyd BA, Baranek GT, Sideris J, et al. Sensory features and repetitive behaviors in children with autism and developmental delays. Autism Res. 2010;3:78–87. 31. Anderson PJ, Reidy N. Assessing executive function in preschoolers. Neuropsychol Rev. 2012;22:345– 360. 32. Orinstein AJ, Helt M, Troyb E, et al. Intervention for optimal outcome in children and adolescents with a history of autism. J Dev Behav Pediatr. 2014;35:247–256.

6个月大的婴儿的社交场景后来被诊断为自闭症谱系障碍。中华精神病学杂志。2013;44(4):391 - 391。30.Boyd BA, Baranek GT, Sideris J，等。自闭症和发育迟缓儿童的感觉特征和重复行为。孤独症研究。2010;3:78-87。31. 学前儿童执行功能的评估。神经心理学，2012;22:345 - 360。32. Orinstein AJ, Helt M, Troyb E，等。干预对有自闭症史的儿童和青少年的最佳结果。[J] .中华儿科杂志，2014;35(5):347 - 356。

引用次数: 2

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