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Journal Article Reviews. 期刊文章评论。
Pub Date : 2017-01-01 DOI: 10.1097/DBP.0000000000000458
Carol Weitzman, Cy B. Nadler, K. Murray, Rachel M. Moore, J. H. Sia
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引用次数: 0
Impact of Mental Health Comorbidities on the Community-Based Pediatric Treatment and Outcomes of Children with Attention Deficit Hyperactivity Disorder 精神健康合并症对儿童注意缺陷多动障碍社区治疗和预后的影响
Pub Date : 2017-01-01 DOI: 10.1097/DBP.0000000000000359
Nour Al Ghriwati, Joshua M. Langberg, W. Gardner, J. Peugh, K. Kelleher, Rebecca A. Baum, William B. Brinkman, P. Lichtenstein, J. Epstein
Objective: Children with attention deficit hyperactivity disorder (ADHD) often exhibit psychiatric comorbidities, which may impact illness presentation, diagnosis, and treatment outcomes. Guidelines exist for dealing with these complex cases but little is known about how comorbidities are being handled in community pediatric settings. The purpose of this study was to evaluate how mental health comorbidities affect community physicians' ADHD care practices and patients' symptom trajectories. Method: Medical charts of 319 children presenting at primary care clinics for ADHD-related concerns were reviewed. Physician assessment and treatment behaviors were extracted and parents rated ADHD symptoms at the time of diagnosis and at 3, 6, and 12 months. Baseline ratings were used to group children, as no comorbid mental health condition, internalizing, or externalizing comorbid condition. Multilevel analyses compared community physician care behaviors and ADHD symptom trajectories across groups. Results: Approximately, 50 percent of the sample met screening criteria for a comorbid mental health condition. For children diagnosed with ADHD and treated with medication, community physician care largely did not differ across groups, but children with internalizing comorbidities made significantly smaller improvements in inattentive and hyperactive/impulsive symptoms compared with children with no comorbidities. Conclusion: Children with ADHD and mental health comorbidities, particularly internalizing disorders, exhibit less robust response to ADHD medication and may require additional testing before starting medication and/or alternative treatment approaches. Potential barriers to conducting comprehensive assessments and to providing multi-modal treatment are discussed.
目的:患有注意缺陷多动障碍(ADHD)的儿童经常表现出精神合并症,这可能会影响疾病的表现、诊断和治疗结果。已有处理这些复杂病例的指南,但对社区儿科环境中如何处理合并症知之甚少。本研究的目的是评估精神健康合并症如何影响社区医生的ADHD护理实践和患者的症状轨迹。方法:回顾了319名在初级保健诊所就诊的adhd相关儿童的病历。提取医生评估和治疗行为,家长在诊断时以及3、6和12个月时对ADHD症状进行评分。基线评分用于对儿童进行分组,分为无共病精神健康状况、内化或外化共病状况。多水平分析比较了社区医生护理行为和不同群体的ADHD症状轨迹。结果:大约50%的样本符合共病精神健康状况的筛查标准。对于诊断为ADHD并接受药物治疗的儿童,社区医生的护理在各组之间基本上没有差异,但与没有合并症的儿童相比,有内化合并症的儿童在注意力不集中和多动/冲动症状方面的改善明显较小。结论:患有ADHD和精神健康合并症的儿童,特别是内化障碍,对ADHD药物的反应较弱,可能需要在开始药物治疗和/或替代治疗方法之前进行额外的测试。讨论了进行综合评估和提供多模式治疗的潜在障碍。
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引用次数: 16
Developmental Coordination Disorder Plus: A Diagnosis by Exclusion? 发展性协调障碍加:排除诊断?
Pub Date : 2017-01-01 DOI: 10.1097/DBP.0000000000000400
J. Santosuosso, K. Strand, B. Surran, N. Rosman, M. Augustyn
CASE Cayden is a 6.3-year-old boy who you have been following in our practice since birth. He was born at 35.5 weeks at 6 pounds 4 ounces following a fraternal twin gestation. Both children were "on target" with their milestones, but Cayden did not seem to progress as quickly as his sister. He did not initiate play with his sister when they were toddlers and Cayden was the "shy" one.
CASECayden是一个6.3岁的男孩,你从他出生起就一直关注他。他在35.5周出生,体重6磅4盎司,是一对异卵双胞胎。两个孩子都“按目标”完成了他们的里程碑,但卡登似乎没有他妹妹进步得快。当他们还在蹒跚学步的时候,他没有主动和他的妹妹玩耍,卡登是“害羞”的那个。
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引用次数: 0
Family Functioning Predicts Body Mass Index and Biochemical Levels of Youths with Nonalcoholic Fatty Liver Disease 家庭功能预测非酒精性脂肪肝青少年体重指数和生化水平
Pub Date : 2017-01-01 DOI: 10.1097/DBP.0000000000000379
J. Smith, Zorash Montaño, A. Maynard, T. Miloh
&NA; Family functioning is associated with obesity-related chronic illnesses and impedes effective treatment of weight-related conditions, such as nonalcoholic fatty liver disease (NAFLD). Objectives: Evaluate the utility of a brief screening measure of family functioning among youth aged 8 to 18 years being treated in a specialty care clinic for NAFLD. Methods: Thirty-nine youths and their caregivers participated. Relations between family functioning and anthropometric and biochemical variables assessed 3 to 6 months later were evaluated using regression analyses, controlling for child age, gender, and ethnicity. Results: Family functioning was related to significantly higher body mass index (BMI) and levels of cholesterol, HbA1c, and glucose, but not serum alanine aminotransferase (ALT)—a marker of NAFLD—controlling for baseline levels. The magnitudes of effects were medium for models of BMI (Cohen's f2 = 0.29), cholesterol (0.32), and blood glucose (0.30) and small to medium for HbA1c (0.23) and ALT (0.10). Conclusion: This is the first study to examine the role of family functioning in youth with NALFD. Treatment programs might consider screening for family functioning to identify families that could benefit from a family-centered behavioral intervention.
患者;家庭功能与肥胖相关的慢性疾病有关,并阻碍了体重相关疾病的有效治疗,如非酒精性脂肪性肝病(NAFLD)。目的:评估在专业护理诊所接受NAFLD治疗的8至18岁青少年家庭功能简短筛查措施的效用。方法:39名青少年及其照顾者参与。在控制儿童年龄、性别和种族的情况下,使用回归分析评估3至6个月后评估的家庭功能与人体测量和生化变量之间的关系。结果:家庭功能与较高的身体质量指数(BMI)、胆固醇、糖化血红蛋白(HbA1c)和葡萄糖水平有关,但与血清丙氨酸转氨酶(ALT) (nafld的标志物)控制基线水平无关。BMI (Cohen's f2 = 0.29)、胆固醇(0.32)和血糖(0.30)模型的影响程度中等,HbA1c(0.23)和ALT(0.10)模型的影响程度中等。结论:这是第一个研究家庭功能在青少年NALFD中的作用的研究。治疗方案可能会考虑对家庭功能进行筛查,以确定可以从以家庭为中心的行为干预中受益的家庭。
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引用次数: 9
Academic Achievement in Adults with a History of Childhood Attention-Deficit/Hyperactivity Disorder: A Population-Based Prospective Study 有儿童注意缺陷/多动障碍史的成人学业成绩:一项基于人群的前瞻性研究
Pub Date : 2017-01-01 DOI: 10.1097/DBP.0000000000000358
R. Voigt, S. Katusic, R. Colligan, J. Killian, A. Weaver, W. Barbaresi
Objective: Previous research on the developmental course of attention-deficit/hyperactivity disorder (ADHD) is limited by biased clinic-referred samples and other methodological problems. Thus, questions about adult academic outcomes associated with childhood ADHD remain unanswered. Thus, the objective of this study was to describe academic outcomes in adulthood among incident cases of research-identified childhood ADHD versus non-ADHD referents from a population-based birth cohort. Method: Young adults with research-identified childhood ADHD (N = 232; mean age 27.0 yr; 72.0% men) and referents (N = 335; mean age 28.6 yr; 62.7% men) from a 1976 to 1982 birth cohort (N = 5699) were invited to participate in a followup study and were administered an academic achievement battery consisting of the basic reading component of the Woodcock-Johnson III Tests of Achievement (WJ-III) and the arithmetic subtest of the Wide Range Achievement Test—Third Edition (WRAT-3). Outcomes were compared between the 2 groups using linear regression models, adjusted for age, sex, and comorbid learning disability status. Results: Childhood ADHD cases scored from 3 to 5 grade equivalents lower on all academic tests compared with referents, with mean (SD) standard scores of 95.7 (8.4) versus 101.8 (8.1) in basic reading; 95.0 (9.3) versus 101.9 (8.5) in letterword identification; 98.2 (8.6) versus 103.2 (9.2) in passage comprehension; 95.7 (9.1) versus 100.9 (9.0) in word attack; and 87.8 (12.9) versus 98.0 (12.0) in arithmetic. Conclusion: This is the first prospective, population-based study of adult academic outcomes of childhood ADHD. Our data provide evidence that childhood onset ADHD is associated with long-term underachievement in reading and math that may negatively impact ultimate educational attainment and occupational functioning in adulthood.
目的:以往关于注意缺陷/多动障碍(ADHD)发展过程的研究受到临床参考样本偏倚和其他方法学问题的限制。因此,关于成人学业成绩与儿童多动症的关系的问题仍然没有答案。因此,本研究的目的是描述在以人口为基础的出生队列中,研究确定的儿童ADHD与非ADHD的参考病例在成年期的学业结果。方法:研究确定患有儿童ADHD的年轻成人(N = 232;平均年龄27.0岁;72.0%男性)和参照物(N = 335;平均年龄28.6岁;从1976年至1982年的出生队列(N = 5699)中,62.7%的男性被邀请参加了一项随访研究,并进行了学术成就测试,包括伍德考克-约翰逊三世成就测试(WJ-III)的基本阅读部分和广义成就测试第三版(WRAT-3)的算术子测试。使用线性回归模型比较两组的结果,并对年龄、性别和共病学习障碍状态进行调整。结果:与参照对象相比,儿童ADHD患者在所有学术测试中的得分低3至5个等级分,基本阅读的平均(SD)标准得分为95.7(8.4)比101.8 (8.1);字母识别能力为95.0(9.3)比101.9 (8.5);段落理解得分为98.2(8.6)比103.2 (9.2);单词攻击95.7(9.1)对100.9 (9.0);87.8(12.9)对98.0(12.0)。结论:这是第一个基于人群的儿童ADHD成人学业成绩的前瞻性研究。我们的数据提供的证据表明,儿童期发病的多动症与长期的阅读和数学成绩不佳有关,这可能对成年后的最终教育成就和职业功能产生负面影响。
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引用次数: 42
Family Functioning and Mood and Anxiety Symptoms in Adolescents Born Extremely Preterm 极度早产青少年的家庭功能、情绪和焦虑症状
Pub Date : 2017-01-01 DOI: 10.1097/DBP.0000000000000368
Alice C. Burnett, Katherine J. Lee, J. Cheong, Cinzia R. De Luca, G. Roberts, S. Wood, L. Doyle, P. Anderson
Objective: To (1) compare adolescent- and parent-perceived family functioning between extremely preterm/extremely low birth weight (<28 wk/<1000 g, EP/ELBW) and normal birth weight (>2499 g, NBW) adolescents and (2) determine whether adolescents' or parents' ratings of family functioning were related to concurrent depression and anxiety symptoms in the adolescent and whether these relationships varied by birth group. Methods: One hundred ninety-three EP/ELBW and 151 NBW adolescents (aged 15–20 yr) and their parents rated aspects of family functioning on the Family Environment Scale. Adolescents rated current depression and anxiety symptoms on the Center for Epidemiologic Studies Depression Scale-Revised and Beck Anxiety Inventory. Family functioning was compared across the groups using linear regression, and logistic regression was used to assess relationships between family functioning domains and elevated depression and anxiety scores. Results: Compared with NBW controls, EP/ELBW adolescents reported similar levels of family Cohesiveness and Expressiveness, but less Conflict, and more Organization and Control. Parent ratings of family functioning were similar between groups except for higher Control scores in EP/ELBW group parents. Poorer family functioning as rated by adolescents, but not parents, was associated with increased depression/anxiety symptoms. These findings were generally consistent across both the EP/ELBW and control groups. Conclusion: EP/ELBW adolescents report generally positive family functioning. While adolescents' perceptions of family functioning are associated with concurrent adolescent mental health, parental perceptions of family functioning may not be indicative of adolescents' mental health. Importantly, EP/ELBW adolescents do not appear to be more vulnerable to anxiety/depression in the context of poorly perceived family functioning than their NBW peers.
目的:(1)比较极早产/极低出生体重(2499 g, NBW)青少年的青少年和父母感知的家庭功能;(2)确定青少年或父母对家庭功能的评价是否与青少年并发抑郁和焦虑症状有关,以及这些关系是否因出生组而异。方法:193名EP/ELBW青少年和151名NBW青少年(15-20岁)及其父母在家庭环境量表上对家庭功能的各个方面进行评分。青少年在流行病学研究中心抑郁量表-修订和贝克焦虑量表上评估当前的抑郁和焦虑症状。使用线性回归比较各组的家庭功能,并使用逻辑回归评估家庭功能域与抑郁和焦虑评分升高之间的关系。结果:与NBW对照组相比,EP/ELBW青少年报告的家庭凝聚力和表达能力水平相似,但冲突较少,组织和控制更多。除了EP/ELBW组父母的Control得分较高外,各组之间的家庭功能父母评分相似。青少年(而不是父母)认为较差的家庭功能与抑郁/焦虑症状的增加有关。这些发现在EP/ELBW组和对照组中基本一致。结论:EP/ELBW青少年普遍报告积极的家庭功能。虽然青少年对家庭功能的看法与青少年心理健康相关,但父母对家庭功能的看法可能并不表明青少年的心理健康。重要的是,EP/ELBW青少年在家庭功能认知不佳的情况下,并不比NBW同龄人更容易出现焦虑/抑郁。
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引用次数: 7
Journal Article Reviews. 期刊文章评论。
Pub Date : 2017-01-01 DOI: 10.1097/DBP.0000000000000422
Carol Weitzman, Rachel M. Moore, J. H. Sia, Sarah S Nyp, K. Murray
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引用次数: 0
"When the Prescription Pad Is Not Enough": Attention-Deficit Hyperactivity Disorder Management 2.0. “当处方笺不够时”:注意缺陷多动障碍管理2.0。
Pub Date : 2017-01-01 DOI: 10.1097/DBP.0000000000000403
Jenny S. Radesky, Arathi Reddy, Naomi J. Steiner, M. Augustyn
CASE Jose is a 13-year-old boy who presents to his primary care provider after struggling in school for many years. When he was in the first grade, he was diagnosed at a tertiary center with attention-deficit hyperactivity disorder. Multiple medication trials have produced few benefits and many side effects including poor sleep, morbid thoughts, lack of motivation, and, according to his parents, "he seemed like a robot."He comes now for his annual physical in April, and the parents tell you that the school is threatening that he be retained in the seventh grade. Parents are very adamant they do not want to try another medication. They have brought you their own and his advisor's Vanderbilt's, which each endorse 7 of 9 inattentive symptoms including trouble organizing, poor attention to detail, and easily distracted and forgetful in daily activities.His birth history and developmental history before beginning formal schooling are unremarkable. His first language was English whereas his parents speak Spanish to each other but not the children. He is healthy and without a history of head trauma, seizures, meningitis, or lead poisoning. An aunt has "learning problems."Jose's family lives in a crowded section of a large urban area. They share an apartment with another family, and both parents are employed full time with his father holding 2 full time jobs working double shifts. Their annual income is at the poverty line. There are 4 children in the family aged between 6 and 13 years.His school has been deemed a "recovery school" because of performing below standard on district-wide achievement tests. His classroom has 27 students, many of whom are English language learners, and he is not on an individualized education plan or 504 accommodations.The family is very concerned about the possibility of retention but have decided that "medicine does not help," and they look to you for other recommendations. Where do you go next?
CASEJose是一个13岁的男孩,他在学校挣扎了多年后,向他的初级保健提供者提出了问题。当他一年级的时候,他被诊断出患有注意力缺陷多动障碍。多次药物试验收效甚微,反而产生了许多副作用,包括睡眠不佳、思想病态、缺乏动力,据他的父母说,“他看起来就像个机器人。”他现在四月来做一年一度的体检,他的父母告诉你,学校威胁要把他留在七年级。家长们非常坚决,他们不想尝试其他药物。他们给你带来了他们自己的和他导师的范德比尔特的,每个人都有9种注意力不集中症状中的7种包括组织困难,对细节的注意力不集中,在日常活动中容易分心和健忘。他的出生史和开始正规教育前的发展历史都不引人注目。他的母语是英语,而他的父母彼此说西班牙语,而不是孩子们。他身体健康,无头部外伤、癫痫、脑膜炎或铅中毒史。一位阿姨有“学习问题”。何塞一家住在大城市的一个拥挤的地区。他们和另一个家庭合租一套公寓,父母都有全职工作,他的父亲有两份全职工作,每天两班倒。他们的年收入在贫困线上。家里有4个孩子,年龄在6到13岁之间。由于在全区成绩测试中的表现低于标准,他的学校被认为是“恢复学校”。他的班级有27名学生,其中许多是英语学习者,他没有参加个性化教育计划或504住宿计划。这家人非常担心孩子可能会潴留,但他们认为“药物没有帮助”,他们向你寻求其他建议。你接下来要去哪里?
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引用次数: 0
Journal Article Reviews. 期刊文章评论。
Pub Date : 2017-01-01 DOI: 10.1097/DBP.0000000000000439
Carol C Weitzman, Sarah S Nyp, J. H. Sia, Cristina E. Farrell, K. Murray
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引用次数: 0
Plagiocephaly and Developmental Delay: A Systematic Review 斜头畸形与发育迟缓:一项系统综述
Pub Date : 2017-01-01 DOI: 10.1097/DBP.0000000000000376
A. Martiniuk, C. Vujovich-Dunn, Miles Park, William Yu, Barbara R Lucas
Objective: Deformational plagiocephaly (includes plagiocephaly and brachycephaly) is a common pediatric condition. Infants who present with altered head shape often experience developmental delay. It is uncertain how common developmental delay is in infants with plagiocephaly and how sustained this is, when present. This review explores the association between plagiocephaly and developmental delay to guide clinical practice. Study Design: A systematic review was conducted. MEDLINE, EMBASE, CINAHL, and PEDro databases were searched. Data from relevant studies were extracted regarding study: sample, follow-up, design, and findings. Methodological quality of each study was rated using a critical appraisal tool. Results: The search recovered 1315 articles of which 19 met the inclusion criteria. In the included studies, the children's ages ranged from 3 months to 10 years. Study limitations included selection bias, nonblinding of assessors, and reuse of the same study population for multiple papers. Most papers (11/19) rated “moderate” on methodological quality. A positive association between plagiocephaly and developmental delay was reported in 13 of 19 studies, including 4 of 5 studies with “strong” methodological quality. Delay was more frequently in studies with children ⩽24 months of age (9/12 studies) compared with >24 months of age (3/7 studies). Motor delay was the most commonly affected domain reported in high-quality papers (5/5 studies). Conclusion: This review suggests plagiocephaly is a marker of elevated risk of developmental delays. Clinicians should closely monitor infants with plagiocephaly for this. Prompt referral to early intervention services such as physiotherapy may ameliorate motor delays and identify infants with longer term developmental needs.
目的:变形性斜头畸形(包括斜头畸形和短头畸形)是一种常见的儿科疾病。出现头部形状改变的婴儿通常会出现发育迟缓。目前尚不清楚斜头畸形婴儿的发育迟缓有多普遍,以及这种发育迟缓在出现时能持续多久。本文旨在探讨斜头畸形与发育迟缓之间的关系,以指导临床实践。研究设计:进行系统评价。检索MEDLINE、EMBASE、CINAHL和PEDro数据库。从相关研究中提取有关研究样本、随访、设计和结果的数据。每个研究的方法学质量使用一个关键的评估工具进行评级。结果:检索到文献1315篇,其中符合纳入标准的文献19篇。在纳入的研究中,儿童的年龄从3个月到10岁不等。研究的局限性包括选择偏倚,评估人员的非盲性,以及在多篇论文中重复使用同一研究人群。大多数论文(11/19)在方法质量上被评为“中等”。19项研究中有13项报告了斜头畸形与发育迟缓之间的正相关,其中5项研究中有4项具有“强”的方法学质量。儿童≥24月龄的研究(9/12)比>24月龄的研究(3/7)发生延迟的频率更高。运动延迟是高质量论文中报道的最常见的受影响的领域(5/5的研究)。结论:本综述提示斜头畸形是发育迟缓风险增高的标志。临床医生应密切监测婴儿斜头畸形。及时转介到早期干预服务,如物理治疗可以改善运动迟缓,并确定婴儿的长期发展需求。
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引用次数: 42
期刊
Journal of Developmental & Behavioral Pediatrics
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