Pub Date : 2022-01-19DOI: 10.1080/17458080.2022.2025781
Zhen-Hong He, Yuan-yuan Wei, N. Li, Yong-Chang Sun, Shao-Yan Yang, Kuan Wang, Weitao Wang, Xiaomei Ma, Zhao-Tie Liu
Abstract Chemical utilization of CO2 is one of the fundamental strategies to synthesize value-added chemicals and reduce the CO2 emission. N-formyl-1,2,3,4-tetrahydroisoquinoline derivatives (FTHIQs) are important chemicals for the synthesis of medical intermediates and alkaloids. N-formylation of isoquinoline derivatives (IQs) with CO2 is an ideal protocol to synthesize the FTHIQs and utilize the CO2 source. In the present work, we prepared a heterogeneous Ru/ZIF-8 catalyst with a Ru loading of 2 wt% by a simple impregnation method and assessed its performances in the N-formylation of IQs and CO2 with H2. The Ru/ZIF-8 catalyst offered high IQ conversion of 98% and FTHIQ selectivity of 93% in the reaction under relatively mild conditions (150 °C, 2 MPa CO2, and 6 MPa H2). The catalyst possessed good universality and reusability, showing a potential in wide application of N-formylation of highly unsaturated nitrogen-containing isoquinolines.
{"title":"N-formylation of isoquinoline derivatives with CO2 and H2 over a heterogeneous Ru/ZIF-8 catalyst","authors":"Zhen-Hong He, Yuan-yuan Wei, N. Li, Yong-Chang Sun, Shao-Yan Yang, Kuan Wang, Weitao Wang, Xiaomei Ma, Zhao-Tie Liu","doi":"10.1080/17458080.2022.2025781","DOIUrl":"https://doi.org/10.1080/17458080.2022.2025781","url":null,"abstract":"Abstract Chemical utilization of CO2 is one of the fundamental strategies to synthesize value-added chemicals and reduce the CO2 emission. N-formyl-1,2,3,4-tetrahydroisoquinoline derivatives (FTHIQs) are important chemicals for the synthesis of medical intermediates and alkaloids. N-formylation of isoquinoline derivatives (IQs) with CO2 is an ideal protocol to synthesize the FTHIQs and utilize the CO2 source. In the present work, we prepared a heterogeneous Ru/ZIF-8 catalyst with a Ru loading of 2 wt% by a simple impregnation method and assessed its performances in the N-formylation of IQs and CO2 with H2. The Ru/ZIF-8 catalyst offered high IQ conversion of 98% and FTHIQ selectivity of 93% in the reaction under relatively mild conditions (150 °C, 2 MPa CO2, and 6 MPa H2). The catalyst possessed good universality and reusability, showing a potential in wide application of N-formylation of highly unsaturated nitrogen-containing isoquinolines.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"61 - 74"},"PeriodicalIF":2.8,"publicationDate":"2022-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43755313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-10-19DOI: 10.1080/17458080.2022.2134563
Catherine C Applegate, Hongping Deng, Brittany L Kleszynski, Tzu-Wen L Cross, Christian J Konopka, L Wawrzyniec Dobrucki, Erik R Nelson, Matthew A Wallig, Andrew M Smith, Kelly S Swanson
The incidence of inflammatory bowel disease (IBD) is increasing worldwide. Although current diagnostic and disease monitoring tests for IBD sensitively detect gut inflammation, they lack the molecular and cellular specificity of positron emission tomography (PET). In this proof-of-concept study, we use a radiolabeled macrophage-targeted nanocarrier probe (64Cu-NOTA-D500) administered by oral, enema, and intraperitoneal routes to evaluate the delivery route dependence of biodistribution across healthy and diseased tissues in a murine model of dextran sodium sulfate (DSS)-induced colitis. High inter-subject variability of probe uptake in intestinal tissue was reduced by normalization to uptake in liver or total intestines. Differences in normalized uptake between healthy and DSS colitis animal intestines were highest for oral and IP routes. Differences in absolute liver uptake reflected a possible secondary diagnostic metric of IBD pathology. These results should inform the preclinical development of inflammation-targeted contrast agents for IBD and related gut disorders to improve diagnostic accuracy.
{"title":"Impact of administration route on nanocarrier biodistribution in a murine colitis model.","authors":"Catherine C Applegate, Hongping Deng, Brittany L Kleszynski, Tzu-Wen L Cross, Christian J Konopka, L Wawrzyniec Dobrucki, Erik R Nelson, Matthew A Wallig, Andrew M Smith, Kelly S Swanson","doi":"10.1080/17458080.2022.2134563","DOIUrl":"10.1080/17458080.2022.2134563","url":null,"abstract":"<p><p>The incidence of inflammatory bowel disease (IBD) is increasing worldwide. Although current diagnostic and disease monitoring tests for IBD sensitively detect gut inflammation, they lack the molecular and cellular specificity of positron emission tomography (PET). In this proof-of-concept study, we use a radiolabeled macrophage-targeted nanocarrier probe (<sup>64</sup>Cu-NOTA-D500) administered by oral, enema, and intraperitoneal routes to evaluate the delivery route dependence of biodistribution across healthy and diseased tissues in a murine model of dextran sodium sulfate (DSS)-induced colitis. High inter-subject variability of probe uptake in intestinal tissue was reduced by normalization to uptake in liver or total intestines. Differences in normalized uptake between healthy and DSS colitis animal intestines were highest for oral and IP routes. Differences in absolute liver uptake reflected a possible secondary diagnostic metric of IBD pathology. These results should inform the preclinical development of inflammation-targeted contrast agents for IBD and related gut disorders to improve diagnostic accuracy.</p>","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"599-616"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9274921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-20DOI: 10.1080/17458080.2021.2016712
N. A. Ibrahim, Saima Bibi, A. Khan, G. Murtaza
Abstract The objective of the current research was to study the effects of polyvinyl alcohol (PVA) electrospun nanofibers loaded with different concentrations of leaf extract of Moringa oleifera (MO) on butyrylcholinesterase (BuChE), monoamine oxidase A (MAO A) and monoamine oxidase B (MAO B) enzymes. The MO-loaded PVA nanofibers were investigated for their inhibitory effect on BuChE and MAO A & B enzymes. The characterization of the fabricated nanofibers was performed by using SEM, FTIR and XRD. The results showed that increasing the concentration of MO, the enzyme inhibition capability of electrospun nanofibers was greatly (p < 0.05) influenced. This study involved the fabrication of electrospun nanofibers of PVA containing four different concentrations of MO (0%, 0.1%, 0.2% and 0.4%). The SEM micrographs revealed that all the nanofibers were porous, beadless and smooth. At a high concentration of M. oleifera, uniform fibers were obtained. The FTIR results of the fabricated nanofibers revealed that chemical interaction did not take place between M. oleifera and polyvinyl alcohol. The results reveal that with an increase in the concentration of M. oleifera (MO), the enzymes inhibition capability of electrospun nanofibers is greatly influenced. Different concentrations of MO extract were successfully loaded to the MMT-reinforced, glutaraldehyde-cross-linked nanofibers.
{"title":"Development and butyrylcholinesterase/monoamine oxidase inhibition potential of PVA-Moringa oleifera developed nanofibers","authors":"N. A. Ibrahim, Saima Bibi, A. Khan, G. Murtaza","doi":"10.1080/17458080.2021.2016712","DOIUrl":"https://doi.org/10.1080/17458080.2021.2016712","url":null,"abstract":"Abstract The objective of the current research was to study the effects of polyvinyl alcohol (PVA) electrospun nanofibers loaded with different concentrations of leaf extract of Moringa oleifera (MO) on butyrylcholinesterase (BuChE), monoamine oxidase A (MAO A) and monoamine oxidase B (MAO B) enzymes. The MO-loaded PVA nanofibers were investigated for their inhibitory effect on BuChE and MAO A & B enzymes. The characterization of the fabricated nanofibers was performed by using SEM, FTIR and XRD. The results showed that increasing the concentration of MO, the enzyme inhibition capability of electrospun nanofibers was greatly (p < 0.05) influenced. This study involved the fabrication of electrospun nanofibers of PVA containing four different concentrations of MO (0%, 0.1%, 0.2% and 0.4%). The SEM micrographs revealed that all the nanofibers were porous, beadless and smooth. At a high concentration of M. oleifera, uniform fibers were obtained. The FTIR results of the fabricated nanofibers revealed that chemical interaction did not take place between M. oleifera and polyvinyl alcohol. The results reveal that with an increase in the concentration of M. oleifera (MO), the enzymes inhibition capability of electrospun nanofibers is greatly influenced. Different concentrations of MO extract were successfully loaded to the MMT-reinforced, glutaraldehyde-cross-linked nanofibers.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"34 - 46"},"PeriodicalIF":2.8,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46960775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Leucus aspera is a perennial plant traditionally used as an herbal medicine in many countries. The biosynthesis of metal nanoparticles using medicinal plants is not only economical but also environmentally friendly as well as having miscellaneous biomedical applications. In this study, Leucus aspera extract as a stabilising and reducing agent was utilised to synthesise Ag nanoparticles in the aqueous medium. In addition, the anti-alveolar cancer property of AgNPs was investigated in the in vitro condition. Various techniques containing UV–Vis. spectroscopy, FT-IR spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy dispersive X-ray spectrometry (EDS) were used to characterise the synthesised nanoparticles. On the other hand, the MTT assay was run to evaluate the cytotoxicity activity of AgNPs. The crystal size of AgNPs, according to the XRD analysis, was 34.22 nm. Moreover, the uniform spherical morphology ranging from 40.67 to 58.17 nm was detected in the SEM images for the biosynthesised nanoparticles. In the antioxidant test, the IC50 of AgNPs and BHT against DPPH free radicals were 87 and 41 µg/mL, respectively. The synthesised nanocomposite had very low cell viability and high anti-alveolar cancer activities against A549 cell line without any cytotoxicity on the normal cell line (HUVEC). The viability of malignant alveolar cell line reduced dose-dependently in the presence of Ag NPs. Perhaps notable anti-alveolar cancer activities of the synthesised nanocomposite against common alveolar cancer cell line are linked to their antioxidant activities.
{"title":"Green synthesis of Ag nanoparticles from Leucus aspera and its application in anticancer activity against alveolar cancer","authors":"Huagen Zhang, Tongfei Li, Wentao Luo, Gui Xia Peng, Jie Xiong","doi":"10.1080/17458080.2021.2007886","DOIUrl":"https://doi.org/10.1080/17458080.2021.2007886","url":null,"abstract":"Abstract Leucus aspera is a perennial plant traditionally used as an herbal medicine in many countries. The biosynthesis of metal nanoparticles using medicinal plants is not only economical but also environmentally friendly as well as having miscellaneous biomedical applications. In this study, Leucus aspera extract as a stabilising and reducing agent was utilised to synthesise Ag nanoparticles in the aqueous medium. In addition, the anti-alveolar cancer property of AgNPs was investigated in the in vitro condition. Various techniques containing UV–Vis. spectroscopy, FT-IR spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy dispersive X-ray spectrometry (EDS) were used to characterise the synthesised nanoparticles. On the other hand, the MTT assay was run to evaluate the cytotoxicity activity of AgNPs. The crystal size of AgNPs, according to the XRD analysis, was 34.22 nm. Moreover, the uniform spherical morphology ranging from 40.67 to 58.17 nm was detected in the SEM images for the biosynthesised nanoparticles. In the antioxidant test, the IC50 of AgNPs and BHT against DPPH free radicals were 87 and 41 µg/mL, respectively. The synthesised nanocomposite had very low cell viability and high anti-alveolar cancer activities against A549 cell line without any cytotoxicity on the normal cell line (HUVEC). The viability of malignant alveolar cell line reduced dose-dependently in the presence of Ag NPs. Perhaps notable anti-alveolar cancer activities of the synthesised nanocomposite against common alveolar cancer cell line are linked to their antioxidant activities.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"47 - 60"},"PeriodicalIF":2.8,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47112688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract In this work, we synthesized folate-conjugated dual-drug loaded double liposomes which are noted for their extremely high target specificity towards pituitary adenomas. It is known that while folate receptors are almost non-existent in normal tissues, they are overexpressed in non-functional pituitary adenomas. Synthesis, characterization and in vitro studies of folate-conjugated dual-drug loaded double liposomes for targeting non-functional pituitary adenomas is the highlight of this study. The size, zeta-potential, polydispersity index, in vitro release studies, stability of the nanoformulation, cytotoxicity and cellular uptake studies have been carried out. It was noted from the results that these are highly targeted liposomal formulation as expressed by the cellular uptake studies and are just sufficiently sized to escape the clearance mechanisms of body. They were also cytocompatible and were stable even after 60 days of shelf life with negligible changes in sizes, zeta potential as well as polydispersity index. The conjugation with folate particles resulted in the high specificity of the formulation to the specific targeted tissue as seen in cellular uptake by primary cell culture of non-functional pituitary adenomas. It may safely be concluded from the results that this approach may be a promising therapy for the future which has low cytotoxicity and high-specificity.
{"title":"Targeting pituitary adenomas with folate-conjugated multiple drug decorated liposomal formulations for improved antiproliferative anticancer efficacy","authors":"Changwei Hu, Xirui Wang, Yabin Li, Xiao Han, Baowen Ren, Gangfeng Yin","doi":"10.1080/17458080.2021.2016711","DOIUrl":"https://doi.org/10.1080/17458080.2021.2016711","url":null,"abstract":"Abstract In this work, we synthesized folate-conjugated dual-drug loaded double liposomes which are noted for their extremely high target specificity towards pituitary adenomas. It is known that while folate receptors are almost non-existent in normal tissues, they are overexpressed in non-functional pituitary adenomas. Synthesis, characterization and in vitro studies of folate-conjugated dual-drug loaded double liposomes for targeting non-functional pituitary adenomas is the highlight of this study. The size, zeta-potential, polydispersity index, in vitro release studies, stability of the nanoformulation, cytotoxicity and cellular uptake studies have been carried out. It was noted from the results that these are highly targeted liposomal formulation as expressed by the cellular uptake studies and are just sufficiently sized to escape the clearance mechanisms of body. They were also cytocompatible and were stable even after 60 days of shelf life with negligible changes in sizes, zeta potential as well as polydispersity index. The conjugation with folate particles resulted in the high specificity of the formulation to the specific targeted tissue as seen in cellular uptake by primary cell culture of non-functional pituitary adenomas. It may safely be concluded from the results that this approach may be a promising therapy for the future which has low cytotoxicity and high-specificity.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"14 - 33"},"PeriodicalIF":2.8,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41981792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-20DOI: 10.1080/17458080.2021.2016713
Yang Nan, Zhuoran Deng, Zhao Xi, Dengfeng Wu
Abstract Herein, α-Al2O3 supported Ag particles with controllable size distribution are prepared successfully by tuning of the calcination conditions through an impregnation method. The size of Ag particles could be adjusted by changing the calcination time and temperature. The catalyst samples were analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and other characterization methods under different calcination conditions, and the performance differences of their catalytic reduction of p-nitrophenol (4-NP) were investigated by UV-Vis spectroscopy. The results show that the Ag particles with increased particle size can be obtained on the surface of α-Al2O3 support by increasing the calcination time or calcination temperature. The catalytic performance of the samples obtained by increasing the calcination time decreased, while the catalytic performance of the samples obtained by increasing the calcination temperature increased. This may be due to the interaction between Ag particles and the support, which changes the valence state of Ag species. Also the particle size effect acts on the catalyst and affects its catalytic performance together with the change of valence.
{"title":"Controlled synthesis of α-Al2O3 supported Ag particles with tuning catalytic performance","authors":"Yang Nan, Zhuoran Deng, Zhao Xi, Dengfeng Wu","doi":"10.1080/17458080.2021.2016713","DOIUrl":"https://doi.org/10.1080/17458080.2021.2016713","url":null,"abstract":"Abstract Herein, α-Al2O3 supported Ag particles with controllable size distribution are prepared successfully by tuning of the calcination conditions through an impregnation method. The size of Ag particles could be adjusted by changing the calcination time and temperature. The catalyst samples were analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and other characterization methods under different calcination conditions, and the performance differences of their catalytic reduction of p-nitrophenol (4-NP) were investigated by UV-Vis spectroscopy. The results show that the Ag particles with increased particle size can be obtained on the surface of α-Al2O3 support by increasing the calcination time or calcination temperature. The catalytic performance of the samples obtained by increasing the calcination time decreased, while the catalytic performance of the samples obtained by increasing the calcination temperature increased. This may be due to the interaction between Ag particles and the support, which changes the valence state of Ag species. Also the particle size effect acts on the catalyst and affects its catalytic performance together with the change of valence.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"17 1","pages":"1 - 13"},"PeriodicalIF":2.8,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47748066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-15DOI: 10.1080/17458080.2021.1970140
R. Santhoshkumar, A. Hima Parvathy, E. Soniya
Abstract In bionanotechnology, nanoparticles synthesis using biological samples is a broadly used technique as it confers lesser toxicity than chemical methods. Leaf extract of Piper colubrinum Link. was used to synthesise green mediated silver nanoparticles (AgNPs). The confirmation and stability of green synthesised silver nanoparticles by UV–visible spectroscopy showed an absorption peak at 410 nm. The synthesised nanoparticles characterised by Fourier transformed infra-red spectroscopy exhibited possible involvement of various functional groups and bio capping of AgNPs and the crystal structure was confirmed by X-ray diffraction data. Further, the size of synthesised silver nanoparticles was confirmed using transmission electron microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and atomic force electron microscopy. The spectroscopic and microscopic analysis confirmed the successful synthesis of AgNPs by P. colubrinum extracts acting as strong reducing agents. Our results showed that reducing the silver nitrate with plant extracts formed sphere-shaped AgNPs with distances in the range of 10–50 nm. XRD analysis revealed the crystal-like nature of the nanoparticles with face-centred cubic structure, and the peaks of the XRD pattern were parallel to (111), (200), (220), and (311) planes. The synthesised AgNPs showed the potential antibacterial activity against foodborne pathogens Escherichia coli and Staphylococcus aureus. Spectrophotometric analysis of dye degradation was confirmed the catalytic activity of synthesised AgNPs. The results of the study revealed potential of phyto-synthesised AgNPs act as catalysts and is a simple and cost effective and efficient approach.
{"title":"Phytosynthesis of silver nanoparticles from aqueous leaf extracts of Piper colubrinum: characterisation and catalytic activity","authors":"R. Santhoshkumar, A. Hima Parvathy, E. Soniya","doi":"10.1080/17458080.2021.1970140","DOIUrl":"https://doi.org/10.1080/17458080.2021.1970140","url":null,"abstract":"Abstract In bionanotechnology, nanoparticles synthesis using biological samples is a broadly used technique as it confers lesser toxicity than chemical methods. Leaf extract of Piper colubrinum Link. was used to synthesise green mediated silver nanoparticles (AgNPs). The confirmation and stability of green synthesised silver nanoparticles by UV–visible spectroscopy showed an absorption peak at 410 nm. The synthesised nanoparticles characterised by Fourier transformed infra-red spectroscopy exhibited possible involvement of various functional groups and bio capping of AgNPs and the crystal structure was confirmed by X-ray diffraction data. Further, the size of synthesised silver nanoparticles was confirmed using transmission electron microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and atomic force electron microscopy. The spectroscopic and microscopic analysis confirmed the successful synthesis of AgNPs by P. colubrinum extracts acting as strong reducing agents. Our results showed that reducing the silver nitrate with plant extracts formed sphere-shaped AgNPs with distances in the range of 10–50 nm. XRD analysis revealed the crystal-like nature of the nanoparticles with face-centred cubic structure, and the peaks of the XRD pattern were parallel to (111), (200), (220), and (311) planes. The synthesised AgNPs showed the potential antibacterial activity against foodborne pathogens Escherichia coli and Staphylococcus aureus. Spectrophotometric analysis of dye degradation was confirmed the catalytic activity of synthesised AgNPs. The results of the study revealed potential of phyto-synthesised AgNPs act as catalysts and is a simple and cost effective and efficient approach.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"16 1","pages":"294 - 308"},"PeriodicalIF":2.8,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47216854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-20DOI: 10.1080/17458080.2021.1957844
Ying Zhang, Yangmei Li, Q. Tan, Song Hong, Zhenyu Sun
Abstract Electrochemical CO2 reduction (ECR) powered by renewable electricity is reckoned to provide an effective strategy to alleviate environmental issues and energy crisis, enabling a potential carbon neutral economy. To boost the ECR to fuels and value-added chemicals, the design of highly active and selective catalysts is important. In this study, we demonstrate facile ultrasonication-facilitated synthesis of two-dimensional copper terephthalate for efficient ECR. High faradaic efficiencies (FEs) of up to 72.9% for hydrocarbons are achieved at a mild overpotential in an H-type cell. In particular, the FE for ethylene (C2H4) formation approaches 50.0% at an applied potential of −1.1 V (vs. the reversible hydrogen electrode), outperforming commercial Cu, Cu2O, CuO, Cu(OH)2 and many recently reported Cu-based materials. The C2H4 partial geometric current density is as high as ∼6.0 mA·cm−2. This work offers a simple avenue to developing advanced electrocatalysts for converting CO2 into high-value hydrocarbons.
{"title":"Facile synthesis of two-dimensional copper terephthalate for efficient electrocatalytic CO2 reduction to ethylene","authors":"Ying Zhang, Yangmei Li, Q. Tan, Song Hong, Zhenyu Sun","doi":"10.1080/17458080.2021.1957844","DOIUrl":"https://doi.org/10.1080/17458080.2021.1957844","url":null,"abstract":"Abstract Electrochemical CO2 reduction (ECR) powered by renewable electricity is reckoned to provide an effective strategy to alleviate environmental issues and energy crisis, enabling a potential carbon neutral economy. To boost the ECR to fuels and value-added chemicals, the design of highly active and selective catalysts is important. In this study, we demonstrate facile ultrasonication-facilitated synthesis of two-dimensional copper terephthalate for efficient ECR. High faradaic efficiencies (FEs) of up to 72.9% for hydrocarbons are achieved at a mild overpotential in an H-type cell. In particular, the FE for ethylene (C2H4) formation approaches 50.0% at an applied potential of −1.1 V (vs. the reversible hydrogen electrode), outperforming commercial Cu, Cu2O, CuO, Cu(OH)2 and many recently reported Cu-based materials. The C2H4 partial geometric current density is as high as ∼6.0 mA·cm−2. This work offers a simple avenue to developing advanced electrocatalysts for converting CO2 into high-value hydrocarbons.","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"16 1","pages":"246 - 254"},"PeriodicalIF":2.8,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/17458080.2021.1957844","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43061961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-12DOI: 10.1080/17458080.2021.1872781
D. Mahendran, P. B. Kavi Kishor, N. Geetha, T. Manish, S. Sahi, P. Venkatachalam
Abstract The biomolecule-coated nanotitania catalysts were synthesised using rhizome extract of Gloriosa superba and the characteristics of the synthesised nanocatalysts were investigated by using various physiochemical methodologies. The antibacterial activity of the biomolecule coated nanotitania catalysts was tested against harmful microbial human pathogens. Nanotitania catalysts were found to be the most potential agent against gram negative bacterium i.e. Staphylococcus epidermidis. An efficient anti-biofilm activity was also observed against biofilm developing bacteria namely S. epidermidis and Pseudomonas aeruginosa. The 50% inhibitory concentration (IC50) of nanotitania catalysts noticed was 46.64 and 61.81 µg/mL for MCF-7 (cancer) L929 (normal) cell lines, respectively. Bioengineered nanotitania catalysts exhibited potential anticancer activity against breast cancer cell line. AO/EtBr staining results show distinct morphological variations such as orange and red coloured apoptotic bodies were identified in cancer cells that were treated with nanotitania catalysts. Further, the nuclear changes, mitochondrial depolarization and increased reactive oxygen species (ROS) level were also detected in nanotitania catalysts treated MCF-7 cells by Hoechst, rhodamine and DCFH-DA probe staining techniques. COMET assay confirmed the DNA destruction in the nanotitania treated cancer cells. In addition, the nanotitania catalysts exhibited potential photocatalytic activity against inorganic toxic dyes and the maximum rate of dye degradation was observed for crystal violet. The present results strongly suggest that the biomolecule coated nanotitania catalysts could be used as potential and novel compound towards biomedical as well as photocatalytic applications. Graphical Abstract
{"title":"Efficient antibacterial/biofilm, anti-cancer and photocatalytic potential of titanium dioxide nanocatalysts green synthesised using Gloriosa superba rhizome extract","authors":"D. Mahendran, P. B. Kavi Kishor, N. Geetha, T. Manish, S. Sahi, P. Venkatachalam","doi":"10.1080/17458080.2021.1872781","DOIUrl":"https://doi.org/10.1080/17458080.2021.1872781","url":null,"abstract":"Abstract The biomolecule-coated nanotitania catalysts were synthesised using rhizome extract of Gloriosa superba and the characteristics of the synthesised nanocatalysts were investigated by using various physiochemical methodologies. The antibacterial activity of the biomolecule coated nanotitania catalysts was tested against harmful microbial human pathogens. Nanotitania catalysts were found to be the most potential agent against gram negative bacterium i.e. Staphylococcus epidermidis. An efficient anti-biofilm activity was also observed against biofilm developing bacteria namely S. epidermidis and Pseudomonas aeruginosa. The 50% inhibitory concentration (IC50) of nanotitania catalysts noticed was 46.64 and 61.81 µg/mL for MCF-7 (cancer) L929 (normal) cell lines, respectively. Bioengineered nanotitania catalysts exhibited potential anticancer activity against breast cancer cell line. AO/EtBr staining results show distinct morphological variations such as orange and red coloured apoptotic bodies were identified in cancer cells that were treated with nanotitania catalysts. Further, the nuclear changes, mitochondrial depolarization and increased reactive oxygen species (ROS) level were also detected in nanotitania catalysts treated MCF-7 cells by Hoechst, rhodamine and DCFH-DA probe staining techniques. COMET assay confirmed the DNA destruction in the nanotitania treated cancer cells. In addition, the nanotitania catalysts exhibited potential photocatalytic activity against inorganic toxic dyes and the maximum rate of dye degradation was observed for crystal violet. The present results strongly suggest that the biomolecule coated nanotitania catalysts could be used as potential and novel compound towards biomedical as well as photocatalytic applications. Graphical Abstract","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"16 1","pages":"11 - 30"},"PeriodicalIF":2.8,"publicationDate":"2021-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/17458080.2021.1872781","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43812561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Expanded polystyrene (EPS) concrete has high environmental and economic benefits. However, the difference in physical and chemical properties leads to a weak interface between EPS and concrete, which limits the use of EPS concrete. Based on the macro experiment of Ethylene Vinyl Acetate Copolymer (EVA) modified EPS concrete, two molecular dynamics interface models of EPS/C-S-H and EPS/EVA/C-S-H were constructed by molecular dynamics simulation, and their interface strengthening mechanism was discussed. The results of interfacial interaction analysis show that EVA increases the interfacial interaction energy and binding energy between EPS and C-S-H, and improves the adhesion between EPS and cement base. The results of radial distribution function analysis show that in the model with the modifier, there are not only Van der Waals forces and hydrogen bonds in the model without the modifier, but also strong interactions such as Ca - = O and OT - = O. The results of mechanical property analysis show that the elastic modulus of EPS concrete interface model after adding modifier is improved, and its interface properties are improved. The molecular dynamics simulation carried out in this paper shows that EVA acts as a bridge between EPS and C-S-H and enhances its interfacial properties. This study can provide basic theoretical support for the application of EPS concrete and reference for the development of high-performance composite cement-based materials. Graphical Abstract
{"title":"EVA enhances the interfacial strength of EPS concrete: a molecular dynamics study","authors":"Yong Feng, Dajing Qin, Lijuan Li, Yuan Li, Chao Wang, Pei-Cao Wang","doi":"10.1080/17458080.2021.2003338","DOIUrl":"https://doi.org/10.1080/17458080.2021.2003338","url":null,"abstract":"Abstract Expanded polystyrene (EPS) concrete has high environmental and economic benefits. However, the difference in physical and chemical properties leads to a weak interface between EPS and concrete, which limits the use of EPS concrete. Based on the macro experiment of Ethylene Vinyl Acetate Copolymer (EVA) modified EPS concrete, two molecular dynamics interface models of EPS/C-S-H and EPS/EVA/C-S-H were constructed by molecular dynamics simulation, and their interface strengthening mechanism was discussed. The results of interfacial interaction analysis show that EVA increases the interfacial interaction energy and binding energy between EPS and C-S-H, and improves the adhesion between EPS and cement base. The results of radial distribution function analysis show that in the model with the modifier, there are not only Van der Waals forces and hydrogen bonds in the model without the modifier, but also strong interactions such as Ca - = O and OT - = O. The results of mechanical property analysis show that the elastic modulus of EPS concrete interface model after adding modifier is improved, and its interface properties are improved. The molecular dynamics simulation carried out in this paper shows that EVA acts as a bridge between EPS and C-S-H and enhances its interfacial properties. This study can provide basic theoretical support for the application of EPS concrete and reference for the development of high-performance composite cement-based materials. Graphical Abstract","PeriodicalId":15673,"journal":{"name":"Journal of Experimental Nanoscience","volume":"16 1","pages":"382 - 396"},"PeriodicalIF":2.8,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45661452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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