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Exploring the hypothetical impact of flavored cigar sales restrictions among black young adult cigar smokers: a semi-structured in-depth interview investigation. 探究对黑人年轻成年雪茄吸食者实施口味雪茄销售限制的假设影响:一项半结构式深度访谈调查。
IF 1.1 4区 医学 Q4 SUBSTANCE ABUSE Pub Date : 2024-07-01 Epub Date: 2022-08-09 DOI: 10.1080/15332640.2022.2109089
Sheila Pakdaman, Aaron Broun, Danielle A Duarte, Aniruddh Ajith, Bambi Jewett, Nicholas Wong, Erin L Mead-Morse, Kelvin Choi, Julia Chen-Sankey

This study assessed the hypothetical impact of flavored cigar sales restrictions on cigar smoking among Black young adult cigar smokers (ages 21-29). Forty in-depth interviews were conducted in 2020. Interviews were independently coded and analyzed using thematic analysis. When asked how they would smoke cigars given a flavor sales restriction, half of participants reported they would smoke in the same way, a third would stop or reduce smoking, and a few were unsure of what they would do. Cigar smoking outcome expectancies, preference for flavors, and perceived addictiveness of cigar products may predict cigar smoking change given flavor sales restrictions.

本研究评估了对黑人年轻成年雪茄吸食者(21-29 岁)销售有香味雪茄的限制对雪茄吸食的假设影响。2020 年进行了 40 次深入访谈。访谈采用主题分析法进行独立编码和分析。当被问及在限制口味销售的情况下他们会如何抽雪茄时,一半的参与者表示会以同样的方式吸烟,三分之一的人会停止或减少吸烟,少数人不确定他们会怎么做。吸雪茄的结果预期、对口味的偏好以及对雪茄产品成瘾性的感知可能会预测在限制雪茄口味销售的情况下雪茄吸食量的变化。
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引用次数: 0
Exploring Twitter chatter to assess the type and availability of cannabis-related products in Thailand. 探索 Twitter 聊天记录,评估泰国大麻相关产品的类型和供应情况。
IF 1.1 4区 医学 Q4 SUBSTANCE ABUSE Pub Date : 2024-07-01 DOI: 10.1080/15332640.2024.2367253
Francois R Lamy, Natthani Meemon

Cannabis-related tweets were collected between January and April 2022 to estimate the availability and characteristics of cannabis products advertised on Twitter amid the legalization of recreational cannabis in Thailand. The Twitter API was called using the tweepy Python library to collect cannabis-related tweets in the Thai language. A total of 185,558 unique tweets were collected over the duration of the data collection period based on 83 search terms. Twenty thousand random tweets were manually coded by four Thai native speakers to assess the volume and characteristics of tweets proposing cannabis. 72.6% of collected tweets from the 20,000 random samples were coded as relevant to the study. 54.6% of relevant tweets were advertising cannabis products, 29.8% were personal communications, and 15.6% were related to news or media content. Among the tweets that advertised cannabis products, 94.4% proposed cannabis flower, 2.4% cannabis edibles and 1.8% cannabis concentrates. Consumption of potent forms of cannabis such as cannabis edibles and concentrates increase the risk of harmful side-effects, especially in a population with limited knowledge about these products. Our findings call for additional monitoring efforts and for increasing the public awareness on potent cannabis products emerging in Thailand.

我们收集了 2022 年 1 月至 4 月期间与大麻有关的推文,以估算在泰国娱乐大麻合法化之际推特上大麻产品广告的可用性和特点。使用 tweepy Python 库调用 Twitter API,以泰语收集与大麻相关的推文。在数据收集期间,根据 83 个搜索词共收集到 185,558 条独特的推文。四名以泰语为母语的人员对两万条随机推文进行了人工编码,以评估有关大麻的推文的数量和特点。从 20,000 个随机样本中收集到的推文中,72.6% 被编码为与本研究相关。54.6% 的相关推文为大麻产品广告,29.8% 为个人通讯,15.6% 与新闻或媒体内容有关。在宣传大麻产品的推文中,94.4% 建议使用大麻花,2.4% 建议食用大麻,1.8% 建议使用浓缩大麻。食用大麻药片和浓缩物等烈性大麻会增加产生有害副作用的风险,尤其是在对这些产品了解有限的人群中。我们的研究结果呼吁加大监测力度,提高公众对泰国出现的烈性大麻产品的认识。
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引用次数: 0
Perceptions and usage of traditional cigarettes, electronic cigarettes, and waterpipes among young and middle-aged adults in Iraq: A descriptive study. 伊拉克中青年对传统香烟、电子香烟和水烟的看法和使用情况:描述性研究。
IF 1.1 4区 医学 Q4 SUBSTANCE ABUSE Pub Date : 2024-07-01 DOI: 10.1080/15332640.2024.2366982
Dastan Tareq Faeq, Darya Rostam Ahmed, Izaddin Ahmad Aziz, Murat Yıldırım

Tobacco use poses significant public health concerns, linked to various mental and physical health outcomes. Iraq has a high prevalence of smoking, predominantly with traditional cigarettes, but there is also growing popularity of electronic cigarettes and waterpipes among younger and middle-aged adults. This study aims to explore the perceptions and usage of traditional cigarettes, electronic cigarettes, and waterpipes among this population in Iraq. A descriptive study was conducted among 402 young and middle-aged adults (50.25% females), aged between 18 and 45 years, with a mean age of 25.88 (SD = 7.27). For the data collection, an online questionnaire was developed utilizing distribution channels on common social networking platforms. The results showed that 41.79% of respondents have used traditional cigarettes, while 31.1% of participants reported that they use electronic cigarettes. Ninety-four per cent of respondents acknowledged that they use waterpipes. The results also indicated that a significant proportion believe that using electronic cigarettes is either much more harmful or more harmful than traditional cigarettes. Participants commonly perceived all three types of tobacco products as highly harmful, including secondhand smoke, addictive qualities, and popularity among peers. Additionally, significant differences in perceptions emerged between smokers and nonsmokers regarding electronic cigarettes and traditional cigarettes, although no such differences were observed for waterpipes. These findings contribute to understanding the attitudes toward different forms of tobacco use among respondents, highlighting the need for targeted interventions to address the perceived harm associated with tobacco products.

烟草使用是重大的公共卫生问题,与各种身心健康后果有关。伊拉克的吸烟率很高,主要是传统香烟,但电子香烟和水烟在中青年中也越来越受欢迎。本研究旨在探讨伊拉克这一人群对传统香烟、电子香烟和水烟的看法和使用情况。研究对象为 402 名中青年成年人(50.25% 为女性),年龄在 18 岁至 45 岁之间,平均年龄为 25.88 岁(SD = 7.27)。为了收集数据,我们利用常见社交网络平台的分发渠道制作了一份在线问卷。结果显示,41.79%的受访者使用过传统香烟,31.1%的参与者表示使用过电子香烟。94% 的受访者承认他们使用水烟。结果还表明,相当大比例的人认为使用电子香烟比传统香烟危害更大或更有害。受访者普遍认为这三种烟草制品的危害都很大,包括二手烟、成瘾性和受同伴欢迎程度。此外,吸烟者和不吸烟者对电子香烟和传统香烟的看法存在明显差异,而对水烟的看法则没有这种差异。这些发现有助于了解受访者对不同形式烟草使用的态度,突出了有针对性地干预烟草产品危害认知的必要性。
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引用次数: 0
PTSD diagnosis and nonmedical use of benzodiazepines among African American incarcerated men: the mitigating effect of John Henry active coping. 创伤后应激障碍诊断与非医疗使用苯二氮卓类药物:约翰-亨利积极应对的缓解作用。
IF 1.1 4区 医学 Q4 SUBSTANCE ABUSE Pub Date : 2024-07-01 Epub Date: 2022-07-23 DOI: 10.1080/15332640.2022.2101575
Paris B Wheeler, Brittany Miller-Roenigk, Jasmine Jester, Danelle Stevens-Watkins

The current study examined the relationship between PTSD and nonmedical use of benzodiazepines (BZDs) based on level of John Henry Active Coping (JHAC) among African American incarcerated men. Data were derived from the Helping Incarcerated Men (HIM) Study (n = 208). Nonmedical use of BZDs was measured for the 30 days before incarceration. Current PTSD diagnosis and JHAC were determined using DSM-5 criteria and the JHAC Scale. Adjusted logistic regression analyses showed PTSD diagnosis was significantly associated with nonmedical BZD use (p = .011), but that JHAC did not significantly mitigate this relationship. African American incarcerated men may experience an unmet need with regards to mental health treatment.

本研究根据非裔美国在押男性的约翰-亨利积极应对(John Henry Active Coping,JHAC)水平,研究了创伤后应激障碍与非医疗使用苯二氮卓(Benzodiazepines,BZDs)之间的关系。数据来自 "帮助被监禁男性(HIM)研究"(n = 208)。对入狱前 30 天内 BZDs 的非医疗使用情况进行了测量。使用 DSM-5 标准和 JHAC 量表确定当前的创伤后应激障碍诊断和 JHAC。调整后的逻辑回归分析表明,创伤后应激障碍诊断与非医用 BZD 的使用显著相关(p = .011),但 JHAC 并未显著缓解这种关系。被监禁的非裔美国人在心理健康治疗方面的需求可能未得到满足。
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引用次数: 0
Hormones, oxidized proteins, and lipids in alcoholism. Duration of remission. 酒精中毒中的激素、氧化蛋白和脂质。缓解持续时间。
IF 1.1 4区 医学 Q4 SUBSTANCE ABUSE Pub Date : 2024-07-01 Epub Date: 2023-11-20 DOI: 10.1080/15332640.2023.2280089
Tamara P Vetlugina, Valentina D Prokopieva, Nikolay A Bokhan, Valentina B Nikitina, Olga A Lobacheva, Anna I Mandel

The instability of remission in alcohol dependence (AD) creates a need to search for criteria for predicting its duration. The aim of study was to determine the hormones, oxidized proteins, and lipids in patients with AD, and the possible relations between these parameters and the duration of remission. Blood samples were obtained from 49 male patients with AD after alcohol detoxification (Total group). Two groups of patients were formed: with unstable therapeutic remission up to 6 months (UTR-group); with stable therapeutic remission which lasted 12 months or longer (STR-group). The control group comprised men without AD. The levels of carbonylated proteins (CP), lipid peroxidation (TBA-RS) were determined in the blood plasma. The levels of cortisol, testosterone total, thyroid-stimulating hormone (TSH), triiodothyronine free (fT3), and thyroxine free (fT4) in the blood serum were measured. The Total group of patients showed an increase in CP, TBA-RS, Cortisol, cortisol/testosterone ratio, and a decrease in TSH, fT3, and fT3/fT4 levels. A set of parameters (T, fT3, fT4, cortisol/testosterone ratio) associated with unstable remission was identified.

酒精依赖(AD)缓解的不稳定性需要寻找预测其持续时间的标准。研究的目的是确定AD患者的激素、氧化蛋白和脂质,以及这些参数与缓解时间之间的可能关系。49例男性AD患者酒精解毒后采血(Total组)。患者分为两组:治疗缓解不稳定达6个月(utr组);治疗缓解稳定持续12个月或更长时间(str组)。对照组由没有AD的男性组成。测定血浆中羰基化蛋白(CP)、脂质过氧化(TBA-RS)水平。测定血清皮质醇、总睾酮、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(fT3)、游离甲状腺素(fT4)水平。Total组患者CP、TBA-RS、皮质醇、皮质醇/睾酮比值升高,TSH、fT3和fT3/fT4水平降低。确定了与不稳定缓解相关的一组参数(T、fT3、fT4、皮质醇/睾酮比值)。
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引用次数: 0
Excess mortality among individuals who have undergone addiction treatment: a study from Greenland. 接受过戒毒治疗的人死亡率过高:格陵兰的一项研究。
IF 1.1 4区 医学 Q4 SUBSTANCE ABUSE Pub Date : 2024-07-01 DOI: 10.1080/15332640.2024.2369328
Julie Flyger, Birgit Niclasen, Anette Søegaard Nielsen, Anna Mejldal

In Greenland, where addiction-related concerns significantly affect well-being, research has explored alcohol's impact on health and mortality. However, no studies have focused on mortality among those who received addiction treatment. This study investigates whether individuals treated for addiction in Greenland experience elevated mortality rates compared to the general population. The study encompassed individuals receiving addiction treatment through the national system between 2012 and December 31, 2022. Data on treatment were sourced from the National Addiction Database, and Statistics Greenland. Person-years at risk were calculated and used to estimate crude mortality rates (CMRs). Adjusted standardized mortality rates (SMRs), accounting for age, sex, and calendar year, were estimated using an indirect method based on observed and expected deaths. Of the 3286 in treatment, 53.9% were women, with a median age of 37. About a third had undergone multiple treatment episodes, and 60.1% received treatment in 2019 or later. The cohort was followed for a median of 2.89 years, yielding 12,068 person-years. The overall CMR was 7.79 deaths per 1000 person-years, with a SMR of 1.42 (95% confidence interval: 1.15; 1.74). Significantly, SMRs differed by age at treatment entry, with younger groups exhibiting higher SMRs (p value = .021). This study found that individuals seeking treatment for addiction problems in Greenland had a higher mortality rate than the general population. Importantly, these SMRs were substantially lower than those observed in clinical populations in other countries.

在格陵兰,与成瘾有关的问题严重影响着人们的福祉,因此研究人员探讨了酒精对健康和死亡率的影响。但是,还没有研究关注接受成瘾治疗者的死亡率。本研究调查了格陵兰接受成瘾治疗者的死亡率是否高于普通人群。研究范围包括 2012 年至 2022 年 12 月 31 日期间通过国家系统接受戒毒治疗的个人。治疗数据来自国家成瘾数据库和格陵兰统计局。研究人员计算了风险年数,并以此估算出粗死亡率(CMR)。调整后的标准化死亡率(SMRs)考虑了年龄、性别和日历年,使用基于观察到的死亡和预期死亡的间接方法进行估算。在接受治疗的 3286 人中,53.9% 为女性,中位年龄为 37 岁。约三分之一的人接受过多次治疗,60.1%的人在 2019 年或之后接受治疗。组群的随访时间中位数为 2.89 年,共计 12068 人年。总体CMR为每千人年7.79例死亡,SMR为1.42(95%置信区间:1.15;1.74)。值得注意的是,SMR 因接受治疗时的年龄而异,年轻群体的 SMR 较高(p 值 = 0.021)。这项研究发现,格陵兰因成瘾问题寻求治疗的人的死亡率高于普通人群。重要的是,这些SMRs大大低于在其他国家临床人群中观察到的SMRs。
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引用次数: 0
Psychological flexibility, self-compassion, subjective well-being, and substance misuse in college students: a serial mediation model. 大学生的心理灵活性、自我同情、主观幸福感与药物滥用:串联中介模型。
IF 1.1 4区 医学 Q4 SUBSTANCE ABUSE Pub Date : 2024-06-26 DOI: 10.1080/15332640.2024.2366981
Gökmen Arslan, Kıvanç Uzun, Ahmet Zeki Güven, Orhan Gürsu

Substance misuse is a pressing public health concern, especially among emerging adults, with implications for psychological health and overall well-being. This cross-sectional study investigates the mediating roles of self-compassion and subjective well-being in the relationship between psychological flexibility and substance misuse among Turkish college students. The study included 445 emerging adults enrolled at a state university in Türkiye. University participants were recruited via convenience sampling using snowball methods. Data were collected using self-report scales. The sample was 69% female (n = 307) and 31% male (n = 138) and ranged in age from 18 to 26 years (M = 20.85, SD = 1.35). In the study, Pearson product-moment correlation analysis was conducted to examine the relationships between the variables and then the serial mediation model was tested. The findings have revealed that psychological flexibility significantly predicts substance misuse, subjective well-being, and self-compassion. Additionally, the study identifies self-compassion as a mediator in the relationship between psychological flexibility and subjective well-being. While self-compassion contributes significantly to well-being, it does not explain the impact of psychological flexibility on substance misuse. Furthermore, subjective well-being also appears to be a mediator in the relationship between psychological flexibility and substance misuse, emphasizing its potential significance in reducing the likelihood of resorting substance misuse. Overall, the study contributes to understanding the pivotal role of self-compassion and psychological flexibility in fostering well-being and preventing substance misuse in the college setting.

药物滥用是一个紧迫的公共健康问题,尤其是在新兴成年人中,对心理健康和整体幸福感都有影响。这项横断面研究调查了自我同情和主观幸福感在土耳其大学生心理灵活性与药物滥用之间关系中的中介作用。研究对象包括 445 名就读于土耳其一所国立大学的新兴成年人。研究人员通过 "滚雪球 "的方便抽样方法招募大学生。数据采用自我报告量表收集。样本中 69% 为女性(n = 307),31% 为男性(n = 138),年龄介于 18 岁至 26 岁之间(M = 20.85,SD = 1.35)。研究采用了皮尔逊积矩相关分析来检验变量之间的关系,然后对序列中介模型进行了检验。研究结果表明,心理灵活性可显著预测药物滥用、主观幸福感和自我同情。此外,研究还发现自我同情是心理灵活性与主观幸福感之间关系的中介。虽然自我同情对幸福感有很大的促进作用,但它并不能解释心理灵活性对药物滥用的影响。此外,主观幸福感似乎也是心理灵活性与药物滥用之间关系的中介因素,这强调了主观幸福感在降低药物滥用可能性方面的潜在意义。总之,本研究有助于理解自我同情和心理灵活性在促进幸福感和防止大学环境中药物滥用方面的关键作用。
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引用次数: 0
The prevalence of kratom use and association with co-occurring substance use among adolescents: a 2022 Bangkok behavioral surveillance survey, Thailand. 泰国 2022 年曼谷行为监测调查:青少年使用桔梗的流行率及其与共用药物使用的关联。
IF 1.1 4区 医学 Q4 SUBSTANCE ABUSE Pub Date : 2024-06-20 DOI: 10.1080/15332640.2024.2367233
Bang-On Thepthien, Isareethika Jayasvasti, Eunyoung Ham

Thailand removed kratom from the list of prohibited substances in 2021, possession and consumption of Kratom is now legal. It is prohibited from selling Kratom to anyone under the age of 18 and/or who is pregnant or breastfeeding. While there are benefits from kratom use with few reported adverse effects, escalating dose and increased use frequency raise the risk for toxic events in the setting of polysubstance use or development of a use disorder. We utilized data from the Behavior Surveillance Survey in Bangkok (n = 5,740) to examine the use of kratom with other substances use in the 12 months before the survey. The prevalence of past-year kratom use among students was 9.3% (95%CI = 8.7-9.9), with higher proportions of males (12.4 versus 6.1%, p < 0.001). The factors associated with past 12-month kratom use were academic performance (Medium GPA; AOR = 2.41, 95% CI = 1.76-3.29; Low GPA; AOR = 4.15, 95% CI = 2.94-5.87), close friend use substance (AOR = 1.94, 95% CI = 1.44-2.59), cannabis use (AOR = 6.84, 95% CI = 4.61-10.15), consumed alcohol (AOR = 2.32, 95% CI = 1.77-3.02), smoked conventional cigarettes (AOR = 4.20, 95% CI = 3.16-5.58), used e-cigarettes (AOR = 4.37, 95% CI = 3.30-5.79) used illicit opioids (AOR = 8.13, 95% CI = 4.35-15.18), and other illicit drug use (AOR = 9.15, 95% CI = 3.78-22.14). These findings may be useful for the initial targeting of efforts to reduce adolescent consumption of kratom. Future studies should examine the effect of regulatory policies or other Thai FDA-related policies use of illicit drugs and e-cigarettes on kratom use.

泰国于 2021 年将 Kratom 从违禁物质清单中删除,拥有和消费 Kratom 现在是合法的。禁止向 18 岁以下和/或怀孕或哺乳期妇女出售 Kratom。虽然使用 Kratom 好处多多,不良反应的报道却很少,但在使用多种物质或出现使用障碍的情况下,剂量的增加和使用频率的提高会增加发生毒性事件的风险。我们利用曼谷行为监测调查(n = 5,740)的数据,研究了调查前 12 个月内使用 kratom 和使用其他药物的情况。学生在过去一年中使用 kratom 的比例为 9.3% (95%CI = 8.7-9.9),其中男性比例较高(12.4% 对 6.1%,P<0.05)。
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引用次数: 0
Enhancing brain health: Swimming-induced BDNF release and epigenetic influence in MS female mouse models. 增强大脑健康:多发性硬化症雌性小鼠模型中游泳诱导的 BDNF 释放和表观遗传学影响。
IF 1.1 4区 医学 Q4 SUBSTANCE ABUSE Pub Date : 2024-06-20 DOI: 10.1080/15332640.2024.2365230
Soheila Banasadegh, Shahnaz Shahrbanian, Reza Gharakhanlou, Mohammad Reza Kordi, Bahram Mohammad Soltani

Multiple sclerosis (MS) is a condition characterized by inflammation in the central nervous system (CNS), impacting sensory, motor, and cognitive abilities. Globally, around three million individuals are affected by MS, with up to 97,000 cases in Iran attributed to genetic predispositions along with various environmental factors like smoking. Cognitive impairment affects a significant portion of patients, ranging from 45% to 70%. This study investigates the impact of regular aerobic swimming exercise for four weeks, mild cognitive impairment induced by encephalomyelitis, and their combination on the expression of microRNA-142-3p and its correlation with the release of brain-derived neurotrophic factor (BDNF) in relation to spatial memory. Twenty-one C57BL/6 mice were divided into three groups. RT-PCR was used for microRNA expression analysis, and BDNF levels were assessed via western blotting. Clinical scores and animal weights were monitored daily. EAE induction led to an increase in microRNA-142-3p expression and a decrease in BDNF levels compared to the control group. Exercise inversed them significantly, and improved spatial memory. Our findings indicate that engaging in regular swimming exercise can counteract the up-regulation of miR-142-3p in brain tissue, which likely contributes to mild cognitive impairment induced by MS. Additionally, the increase in BDNF following exercise appears to be associated with miR-142-3p and the enhancement of cognitive function. Thus, the therapeutic benefits of exercise, particularly in releasing BDNF to improve cognitive function in MS patients, warrant consideration. Lifestyle modifications have the potential to effectively modulate environmental influences and ethnicity, underscoring their significance in MS management.

多发性硬化症(MS)是一种以中枢神经系统(CNS)炎症为特征的疾病,影响患者的感觉、运动和认知能力。全球约有三百万人受到多发性硬化症的影响,伊朗有多达 97,000 个病例是由于遗传倾向和吸烟等各种环境因素造成的。认知障碍影响了很大一部分患者,占 45% 到 70%。本研究调查了为期四周的定期有氧游泳运动、脑脊髓炎诱发的轻度认知障碍以及两者结合对微小RNA-142-3p表达的影响及其与脑源性神经营养因子(BDNF)释放的相关性。21 只 C57BL/6 小鼠被分为三组。微RNA表达分析采用RT-PCR技术,BDNF水平则通过Western印迹法进行评估。每天监测临床评分和动物体重。与对照组相比,EAE诱导导致microRNA-142-3p表达增加,BDNF水平下降。运动能显著逆转这两种情况,并改善空间记忆。我们的研究结果表明,有规律的游泳运动可以抵消脑组织中miR-142-3p的上调,而miR-142-3p很可能是多发性硬化症诱发轻度认知障碍的原因之一。此外,运动后 BDNF 的增加似乎与 miR-142-3p 和认知功能的增强有关。因此,运动的治疗效果,尤其是释放 BDNF 以改善多发性硬化症患者认知功能的效果值得考虑。改变生活方式有可能有效地调节环境影响和种族因素,因此在多发性硬化症的治疗中具有重要意义。
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引用次数: 0
Systemic biases promoting the under-inclusion of marginalized groups in randomized controlled trials for co-occurring alcohol use and posttraumatic stress disorder: an intersectional analysis. 系统性偏见导致边缘化群体未被充分纳入治疗并发酗酒和创伤后应激障碍的随机对照试验:交叉分析。
IF 1.3 4区 医学 Q4 SUBSTANCE ABUSE Pub Date : 2024-06-17 DOI: 10.1080/15332640.2024.2367240
Mallet R Reid, Nicole T Buchanan

Co-occurring posttraumatic stress disorder and alcohol use disorder is a major public health concern affecting millions of people. Although this disorder affects people from all groups, research shows that, when compared to White people, people of color systematically suffer worse chronicity and burden of disorder. Additionally, research shows that people of color endure a variety of barriers to accessing treatment and often require specialized or culturally appropriate care. Consequently, the array of treatments available must have been determined to be effective for people of color when they access treatment, and people of color must be well represented in research to ensure effective treatment. Therefore, randomized controlled trials testing treatments for this disorder must include racially diverse samples and ensure treatments are effective for all groups. Further, if they lack diversity, it is necessary to explore whether and how the process of conducting randomized controlled trials is biased toward the constrained inclusion of people of color. This study used a Matrix of Domination framework as an intersectional method to investigate this question. It assessed the inclusion of people by race and sex in randomized controlled trials for co-occurring posttraumatic stress disorder and alcohol use disorder. We found that people of color and White women are significantly underincluded in randomized controlled trials and that these studies are hegemonically, disciplinarily, and structurally biased in ways that facilitate the overrepresentation of White men and the underrepresentation of marginalized groups.

创伤后应激障碍和酒精使用障碍并发症是影响数百万人的主要公共健康问题。尽管这种疾病影响着所有群体的人,但研究表明,与白人相比,有色人种的慢性病和疾病负担更重。此外,研究还表明,有色人种在获得治疗方面面临各种障碍,通常需要专门的或文化上适当的护理。因此,在有色人种接受治疗时,必须确定现有的一系列治疗方法对他们有效,而且有色人种在研究中必须有充分的代表性,以确保治疗的有效性。因此,测试该疾病治疗方法的随机对照试验必须包括不同种族的样本,并确保治疗方法对所有群体都有效。此外,如果缺乏多样性,就有必要探讨随机对照试验的开展过程是否以及如何偏向于限制有色人种的参与。本研究使用 "支配矩阵 "框架作为交叉方法来研究这一问题。它评估了在治疗创伤后应激障碍和酒精使用障碍并发症的随机对照试验中按种族和性别纳入人群的情况。我们发现,有色人种和白人女性在随机对照试验中的参与度明显偏低,而且这些研究在霸权、学科和结构上存在偏差,导致白人男性的参与度过高,而边缘化群体的参与度偏低。
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Journal of Ethnicity in Substance Abuse
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