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2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310)最新文献

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Preliminary studies of a micro-CT for a combined small animal PET/CT scanner 微型CT用于小型动物PET/CT联合扫描仪的初步研究
Pub Date : 2001-11-04 DOI: 10.1109/NSSMIC.2001.1008647
M. Khodaverdi, F. Pauly, S. Weber, G. Schroder, K. Ziemons, R. Sievering, H. Halling
We are developing an X-ray computed tomography (CT) system which will be combined with a high resolution animal PET system. This permits acquisition of both molecular and anatomical images in a single machine. In particular the CT will also be utilized for the quantification of the animal PET data by providing accurate data for attenuation correction. A first prototype has been built using a commercially available plane silicon diode detector. A cone-beam reconstruction provides the images using the Feldkamp algorithm. First measurements with this system have been performed on a mouse. It could be shown that the CT setup fulfils all demands for a high quality image of the skeleton of the mouse. It is also suited for soft tissue measurements. To improve contrast and resolution and to acquire the X-ray energy further development of the system, especially the use of semiconductor detectors and iterative reconstruction algorithms are planned.
我们正在开发一种x射线计算机断层扫描(CT)系统,它将与高分辨率动物PET系统相结合。这允许在一台机器中获取分子和解剖图像。特别是,CT还将通过为衰减校正提供准确的数据来用于动物PET数据的量化。第一个原型已经建成使用商用平面硅二极管探测器。锥束重建提供了使用费尔德坎普算法的图像。该系统的首次测量已在鼠标上进行。可以看出,CT设置满足了对小鼠骨骼高质量图像的所有要求。它也适用于软组织测量。为了提高对比度和分辨率并获取x射线能量,计划进一步发展该系统,特别是使用半导体探测器和迭代重建算法。
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引用次数: 21
Modeling SPECT acquisition and processing of changing radiopharmaceutical distributions 模拟SPECT获取和处理变化的放射性药物分布
Pub Date : 2001-11-04 DOI: 10.1109/NSSMIC.2001.1008591
Ji Chen, J. Galt, J. Valentine, T. Faber, E.V. Garcia
The accuracy of SPECT images is compromised and artifacts may be produced when the radiopharmaceutical distribution changes during image acquisition. Optimization of SPECT acquisition protocols for changing tracer distributions can be difficult not only in patient studies (undesirability of performing repeat studies on the same patient) but also in phantom studies (difficulty of emulating the changing distributions). This study proposes a simulation that allows computer modeling of both tracer kinetics and different acquisition schemes. /sup 99m/Tc Teboroxime (Bracco Diagnostics) is used as a model. SPECT acquisition of a software phantom (NCAT, UNC Chapel Hill) is simulated with photon attenuation, collimator resolution, Compton scatter, Poisson noise, and changing tracer distribution. Short-axis uniformity is used to assess the severity of artifacts in the myocardium. The simulation produces similar artifacts to those found in patient studies with /sup 99m/Tc Teboroxime. This simulation methodology can provide a valuable tool for testing novel acquisition and processing techniques and to facilitate the optimization of SPECT images of changing tracer distributions. Summed fanning (back and forth) acquisitions have been tested and artifact reduced short-axis images obtained. Image restoration techniques are proposed to further improve the image quality. Furthermore, the simulated studies can be compared to the simulations with assigned low liver uptake and no tracer clearance from the myocardium to detect and resolve artifacts through variations in the acquisition and processing schemes.
在图像采集过程中,当放射性药物分布发生变化时,SPECT图像的准确性会受到影响,并可能产生伪影。改变示踪剂分布的SPECT采集方案的优化不仅在患者研究(不希望对同一患者进行重复研究)中很困难,而且在模拟研究(难以模拟变化的分布)中也很困难。本研究提出了一种模拟方法,可以对示踪剂动力学和不同的获取方案进行计算机建模。/sup 99m/Tc使用tebor肟(Bracco Diagnostics)作为模型。用光子衰减、准直器分辨率、康普顿散射、泊松噪声和示踪剂分布的变化对软件幻影(NCAT, UNC Chapel Hill)的SPECT采集进行了模拟。短轴均匀性用于评估心肌伪影的严重程度。模拟产生的伪影与使用/sup 99m/Tc替博肟的患者研究中发现的伪影相似。这种模拟方法可以为测试新的采集和处理技术提供有价值的工具,并有助于优化改变示踪剂分布的SPECT图像。总结扇形(来回)收购已经测试和伪影减少短轴图像获得。为了进一步提高图像质量,提出了图像恢复技术。此外,模拟研究可以与指定低肝脏摄取和无心肌示踪剂清除的模拟进行比较,从而通过获取和处理方案的变化来检测和解决伪影。
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引用次数: 6
Optimisation of fibre-optic readout of LSO scintillation crystals with acid etching 酸蚀法优化LSO闪烁晶体的光纤读出
Pub Date : 2001-11-04 DOI: 10.1109/NSSMIC.2001.1009207
D. Strul, J. Sutcliffe-Goulden, P. Halstead, P. Marsden
Optimising the collection of scintillation light is essential for good PET scanner performance, and even more so when the crystals are read out through optical fibres. Acid etching had been proposed as a cost-effective alternative to mechanical polishing, but there are discrepancies between the results published so far. The aim of this work is to gain a better understanding of acid etching and of its effects on the light yield and to assess its application to fibre-optic based configurations, We have examined the surface state of LSO crystals etched for various times and measured their light output in different configurations, with both direct and fibre-optic readout. Our results indicate that crystal etching is a complex process, where different crystal faces may be etched in different ways. Acid etching always resulted in an improvement the light yield and energy resolution of the crystals, and was as efficient as or in many cases superior to, mechanical polishing. While this improvement was somewhat limited for the configurations with direct readout of the crystals we tested, it was much larger for the fibre-optic based configuration.
优化闪烁光的收集对于良好的PET扫描仪性能至关重要,当晶体通过光纤读出时更是如此。酸蚀刻已被提出作为一种具有成本效益的机械抛光替代方案,但迄今为止发表的结果之间存在差异。这项工作的目的是为了更好地理解酸蚀刻及其对光产率的影响,并评估其在光纤结构中的应用。我们研究了不同时间蚀刻的LSO晶体的表面状态,并测量了它们在不同结构下的光输出,包括直接和光纤读出。我们的研究结果表明,晶体蚀刻是一个复杂的过程,其中不同的晶面可能以不同的方式蚀刻。酸蚀刻总是导致晶体的光产率和能量分辨率的提高,并且在许多情况下与机械抛光一样有效或优于机械抛光。虽然这种改进对我们测试的直接读出晶体的配置有一定的限制,但对于基于光纤的配置,这种改进要大得多。
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引用次数: 10
A bootstrap approach for analyzing the statistical properties of SPECT and PET images 一种分析SPECT和PET图像统计特性的自举方法
Pub Date : 2001-11-04 DOI: 10.1109/NSSMIC.2001.1008603
I. Buvat, C. Riddell
We describe a non-parametric bootstrap method to estimate the statistical properties of single photon emission computed tomography (SPECT) and positron emission tomography (PET) images, whatever the type of noise in the projections and the reconstruction algorithm. Using analytical simulations and real PET data, this method is shown to accurately predict the statistical distribution, hence the variance, of reconstructed pixel values for both linear and nonlinear reconstruction algorithms.
我们描述了一种非参数自举方法来估计单光子发射计算机断层扫描(SPECT)和正电子发射断层扫描(PET)图像的统计特性,无论投影和重建算法中的噪声类型如何。通过分析仿真和真实PET数据,该方法可以准确地预测线性和非线性重建算法的重建像素值的统计分布,从而预测方差。
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引用次数: 10
First results of a dedicated breast PET imager, BPET, using NaI(Tl) curve plate detectors 使用NaI(Tl)曲线板检测器的专用乳房PET成像仪BPET的第一个结果
Pub Date : 2001-11-04 DOI: 10.1109/NSSMIC.2001.1008560
R. Freifelder, C. Cardi, I. Grigoraş, J. Saffer, J. Karp
We present the first imaging results from phantom measurements of a dedicated, breast-only positron emission imager, BPET, using NaI(Tl) Curve Plate detectors. The scanner uses 19 mm thick NaI(Tl) detectors in a split-ring design which surrounds the breast as the woman lies prone and the breast hangs down from the body. Because the detectors are close to the breast and the scanner detects photons that do not pass through the body, system sensitivity and spatial resolution are both optimized. The split ring design provides for flexibility for needle aspirations of masses or alternate viewing orientations. We have measured energy resolution, spatial resolution, scatter fraction, and system sensitivity. We have compared the BPET scanner's performance to our clinical whole-body scanner using a breast phantom with hot spheres simulating lesions. The results show that for activity concentrations that correspond to clinical FDG doses, the dedicated scanner has better lesion detectability than the whole-body scanner for the 20 cm detector separation used.
我们介绍了使用NaI(Tl)曲线板探测器的专用乳房正电子发射成像仪BPET的幻影测量的第一个成像结果。该扫描仪使用19毫米厚的NaI(Tl)探测器,在女性俯卧时环绕乳房,乳房垂下。由于探测器靠近乳房,扫描仪检测不穿过身体的光子,因此系统灵敏度和空间分辨率都得到了优化。分离环的设计提供了灵活的针的愿望群众或替代观看方向。我们已经测量了能量分辨率、空间分辨率、散射分数和系统灵敏度。我们将BPET扫描仪的性能与我们的临床全身扫描仪进行了比较,该扫描仪使用带有热球模拟病变的乳房假体。结果表明,对于与临床FDG剂量相对应的活性浓度,专用扫描仪比全身扫描仪具有更好的病变检测能力,使用20 cm检测器分离。
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引用次数: 32
Results from a nuclear microprobe analysis of selected rare earth fluor materials 选定稀土含氟材料的核探针分析结果
Pub Date : 2001-11-04 DOI: 10.1109/NSSMIC.2001.1008477
W. Hollerman, E. Gates, P. Boudreaux, G. Glass
Until recently, it was difficult to measure properties of individual fluor grains. The development of an accelerator-based nuclear microprobe, currently available at the Louisiana Accelerator Center (LAC), has made this type of research possible. Using ion beams as small as 1 /spl times/ 1 /spl mu/m (horizontal /spl times/ vertical extent), it is now possible to measure properties of individual fluor grains. Starting in 2000, a research program was initiated to determine the microscopic fluorescence properties for selected rare earth compounds, like Y/sub 2/O/sub 2/S:Eu. Particle induced X-ray emission (PIXE) was used to characterize individual fluor grains. Individual Y/sub 2/O/sub 2/S:Eu grains are clearly visible in the analysis and are less than 10 /spl mu/m in extent.
直到最近,很难测量单个面粉颗粒的特性。路易斯安那加速器中心(LAC)开发的一种基于加速器的核微探针使这类研究成为可能。使用小到1 /spl倍/ 1 /spl μ /m(水平/spl倍/垂直范围)的离子束,现在可以测量单个颗粒的特性。从2000年开始,一项研究计划启动,以确定选定的稀土化合物的微观荧光特性,如Y/sub 2/O/sub 2/S:Eu。粒子诱导x射线发射(PIXE)用于表征单个氟颗粒。单个Y/sub 2/O/sub 2/S:Eu颗粒在分析中清晰可见,范围小于10 /spl mu/m。
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引用次数: 3
Collimator blurring reduction method using fine angular sampling projection data in SPECT 基于SPECT精细角度采样投影数据的准直器模糊消除方法
Pub Date : 2001-11-04 DOI: 10.1109/NSSMIC.2001.1009246
N. Motomura, K. Nambu, A. Kojima, S. Tomiguchi, K. Ogawa
Due to the collimator aperture, the spatial resolution of SPECT data varies with source-to-detector distance. Since radius of detector rotation is bigger when scanning larger patients, the spatial resolution is degraded in these cases. Emitted gamma rays travel not only along the central axis of the collimator hole but also off-axis due to collimator aperture. However, an off-axis ray at one angle would be a central-axis ray at another angle; therefore, raw projection data at one angle can be thought of as an ensemble of central-axis rays collected from a small arc equal to collimator aperture. Thus, fine angular sampling can compensate for collimator blurring. By using sampling pitch of less than half the collimator aperture angle, compensation was performed by subtracting the weighted sum of the projection data from the raw projection data. Collimator geometry and detector rotation radius determined the weighting function. A cylindrical phantom with four different-sized rods and torso phantom for Tl-201 cardiac SPECT simulation were used for evaluation. Aperture angle of the collimator was 7 degrees. Projection sampling pitch was 2 degrees. In both phantom studies, the proposed method showed improvement in contrast and reduction of partial volume effect, thereby indicating that the proposed method can compensate adequately for image blurring caused by collimator aperture.
由于准直器孔径的影响,SPECT数据的空间分辨率随源到探测器距离的变化而变化。由于扫描体型较大的患者时,检测器旋转半径较大,导致空间分辨率下降。发射的伽马射线不仅沿着准直器孔的中心轴传播,而且由于准直器孔径而偏离轴。然而,在一个角度的离轴射线在另一个角度将是一个中轴射线;因此,在一个角度的原始投影数据可以被认为是从一个等于准直器孔径的小弧收集的中心轴射线的集合。因此,精细的角度采样可以补偿准直器模糊。采用小于准直器孔径角一半的采样间距,从原始投影数据中减去投影数据的加权和进行补偿。准直器的几何形状和探测器的旋转半径决定了加权函数。采用具有四根不同大小棒的圆柱形幻像和用于Tl-201心脏SPECT模拟的躯干幻像进行评估。准直器孔径角为7度。投影采样螺距为2度。在两项幻像研究中,所提出的方法都显示出对比度的提高和部分体积效应的减少,从而表明所提出的方法可以充分补偿准直器孔径引起的图像模糊。
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引用次数: 0
High-resolution x-ray imaging using Rowland-circle Bragg optics 高分辨率x射线成像使用罗兰圈布拉格光学
Pub Date : 2001-11-04 DOI: 10.1109/NSSMIC.2001.1008617
U. Bergmann, M. Ivanovic, P. Glatzel, S. Cramer
A new approach to high-resolution imaging of radio-labeled agents based on Rowland circle x-ray optics is presented. Perfect-crystal Bragg optics is widely used in x-ray research due to its high reflectivity and excellent energy resolution. The nature of Bragg reflections directly correlates energy and spatial resolution, therefore yielding good imaging properties. Applied in a one to one focusing Rowland geometry, an array of spherically bent Bragg crystals can provide a large solid angle acceptance required for efficient imaging. The potential advantage over e.g. SPECT is twofold. First, focusing optics provides a 'virtual pinhole' which can effectively be inside the object under investigation and does not suffer from edge effects and scattering. Second, Bragg optics has an energy resolution of a few eV and discriminates against inelastic Compton scattering, a common source for image blurring. Studies using /sup 55/Fe and /sup 95m/Tc phantoms are presented, where a spatial resolution of less than 1 mm and 2 mm was achieved respectively.
提出了一种基于罗兰圆x射线光学的高分辨率放射性标记剂成像新方法。完美晶体布拉格光学由于其高反射率和优异的能量分辨率而广泛应用于x射线研究。布拉格反射的性质与能量和空间分辨率直接相关,因此产生良好的成像特性。应用于一对一聚焦罗兰几何,球形弯曲布拉格晶体阵列可以提供有效成像所需的大立体角接受。与SPECT相比,其潜在优势是双重的。首先,聚焦光学提供了一个“虚拟针孔”,它可以有效地进入被调查的物体内部,并且不会受到边缘效应和散射的影响。其次,Bragg光学具有几个eV的能量分辨率,并且可以区分非弹性康普顿散射,这是图像模糊的常见来源。本文介绍了使用/sup 55/Fe和/sup 95m/Tc模型的研究,分别获得了小于1 mm和2 mm的空间分辨率。
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引用次数: 1
Evaluation of different types of avalanche photo diodes from Hamamatsu and Perkin-Elmer 来自Hamamatsu和Perkin-Elmer的不同类型雪崩光电二极管的评价
Pub Date : 2001-11-04 DOI: 10.1109/NSSMIC.2001.1009694
Liu Jiangui, A. Fremout, P. Bruyndonckx, S. Tavernier, J. Loude, C. Morel
Avalanche photodiodes (APD) could replace photomultiplier tubes (PMT) in some areas like positron emission tomography (PET). It is therefore important to study their performance. In this study, we have tested two types of APD's, the Hamamatsu S5345W and the Perkin-Elmer C30719E. We evaluated and compared the dark current, the gain and the excess noise factor of these two APD types.
雪崩光电二极管(APD)在正电子发射断层扫描(PET)等领域可以取代光电倍增管(PMT)。因此,研究它们的性能是很重要的。在本研究中,我们测试了两种类型的APD, Hamamatsu S5345W和Perkin-Elmer C30719E。我们对这两种APD的暗电流、增益和多余噪声系数进行了评价和比较。
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引用次数: 2
Characterization of CdTe crystals grown by the Vertical Bridgman method 垂直布里奇曼法生长CdTe晶体的表征
Pub Date : 2001-11-04 DOI: 10.1109/NSSMIC.2001.1009281
M. Fiederle, A. Fauler, V. Babentsov, J. Franc, J. Ludwig, K. Benz
CdTe crystals had been grown by the Vertical Bridgman method with diameters from 25 mm up to 75 mm. To obtain stable growth conditions the growth rate and temperature gradient had been adjusted by in-situ temperature monitoring. Several modifications had been applied to improve crystallinity. The effort of the improvements could be demonstrated by reduction of twins and the growth of large single crystalline grains up to 40/spl times/40 mm/sup 2/. Different dopants had been applied to obtain resistivities of 5/spl times/10/sup 8/ Ohmcm up to 2/spl times/10/sup 10/ Ohmcm.
用垂直布里奇曼法生长出直径从25毫米到75毫米的碲化镉晶体。为了获得稳定的生长条件,通过现场温度监测调节生长速率和温度梯度。为了提高结晶度,采用了几种改性方法。改进的努力可以通过孪晶的减少和大单晶晶粒的生长来证明,其生长速度可达40/spl倍/40 mm/sup / 2/。采用不同的掺杂剂可获得5/spl倍/10/sup 8/欧姆至2/spl倍/10/sup 10/欧姆的电阻率。
{"title":"Characterization of CdTe crystals grown by the Vertical Bridgman method","authors":"M. Fiederle, A. Fauler, V. Babentsov, J. Franc, J. Ludwig, K. Benz","doi":"10.1109/NSSMIC.2001.1009281","DOIUrl":"https://doi.org/10.1109/NSSMIC.2001.1009281","url":null,"abstract":"CdTe crystals had been grown by the Vertical Bridgman method with diameters from 25 mm up to 75 mm. To obtain stable growth conditions the growth rate and temperature gradient had been adjusted by in-situ temperature monitoring. Several modifications had been applied to improve crystallinity. The effort of the improvements could be demonstrated by reduction of twins and the growth of large single crystalline grains up to 40/spl times/40 mm/sup 2/. Different dopants had been applied to obtain resistivities of 5/spl times/10/sup 8/ Ohmcm up to 2/spl times/10/sup 10/ Ohmcm.","PeriodicalId":159123,"journal":{"name":"2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125228760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
期刊
2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310)
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