{"title":"Effects of Soaking, Cooking, and Steaming Treatments on the Faba Bean Seeds’ Total Bioactive Compounds Content and Antioxidant Activity","authors":"Almagor Meital, Demri Avi, G. Liel, Bellalou Aharon, Amir-Segev Orit, Galili Shmuel","doi":"10.12691/jfnr-11-1-9","DOIUrl":"https://doi.org/10.12691/jfnr-11-1-9","url":null,"abstract":",","PeriodicalId":16096,"journal":{"name":"Journal of Food and Nutrition Research","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41889373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-15DOI: 10.55289/jnutres/v11i1_22.20
A. Krishnamurthy, S. Timmanpyati, Sachdev Meenakshi, E. Canday, P. Mahajan, K. Talapatra, J. Paranjape, Gargee Rai, Safala Mahadik, Shilpa Thakur, S. S. Deo, K. Prabhash, S. Rajappa, Sreemathy Venkatraman, Ipsita Chakravarti, Manju George, Shruti Bhrdwaj, Susan Itty, Shifali Mehraa, Fagun Gandhi, R. Kothari, Vasudha Mathur, R. Shukla, Z. Patel, Vilasini Raman, A. Balaji, A. Rajeshwari
Nutritional support is an integral component in the treatment of head and neck cancers (HNC). Studies indicate 90% of HNC patients are at high risk of developing malnutrition. Chemo-radiation and surgery, the three common treatments used to treat HNC are highly susceptible to toxic side effects. Dysphagia is often underestimated in HNC patients. A prolonged impaired swallowing process can lead to severe morbidities like malnutrition, dehydration, aspiration, pneumonia, and even death. These complications have adverse effects on patients' QoL (Quality of Life) and mental health. These adverse reactions further complicate the nutritional status of the patients and the final treatment outcome, increasing morbidity and mortality. The consensus statements try to address nutritional issues and provide practical recommendations for practicing dieticians and clinicians. Keywords: Head and neck cancer guidelines, Nutrition in head and neck cancers, Consensus statements in nutrition in Head and neck cancers, IAPEN head and neck cancer guidelines
{"title":"IAPEN INDIA Consensus Statement on Nutritional Management in Head and Neck Cancers","authors":"A. Krishnamurthy, S. Timmanpyati, Sachdev Meenakshi, E. Canday, P. Mahajan, K. Talapatra, J. Paranjape, Gargee Rai, Safala Mahadik, Shilpa Thakur, S. S. Deo, K. Prabhash, S. Rajappa, Sreemathy Venkatraman, Ipsita Chakravarti, Manju George, Shruti Bhrdwaj, Susan Itty, Shifali Mehraa, Fagun Gandhi, R. Kothari, Vasudha Mathur, R. Shukla, Z. Patel, Vilasini Raman, A. Balaji, A. Rajeshwari","doi":"10.55289/jnutres/v11i1_22.20","DOIUrl":"https://doi.org/10.55289/jnutres/v11i1_22.20","url":null,"abstract":"Nutritional support is an integral component in the treatment of head and neck cancers (HNC). Studies indicate 90% of HNC patients are at high risk of developing malnutrition. Chemo-radiation and surgery, the three common treatments used to treat HNC are highly susceptible to toxic side effects. Dysphagia is often underestimated in HNC patients. A prolonged impaired swallowing process can lead to severe morbidities like malnutrition, dehydration, aspiration, pneumonia, and even death. These complications have adverse effects on patients' QoL (Quality of Life) and mental health. These adverse reactions further complicate the nutritional status of the patients and the final treatment outcome, increasing morbidity and mortality. The consensus statements try to address nutritional issues and provide practical recommendations for practicing dieticians and clinicians. Keywords: Head and neck cancer guidelines, Nutrition in head and neck cancers, Consensus statements in nutrition in Head and neck cancers, IAPEN head and neck cancer guidelines","PeriodicalId":16096,"journal":{"name":"Journal of Food and Nutrition Research","volume":"8 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86730979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-15DOI: 10.55289/jnutres/v11i1_23.3
Shahana Gupta, S. Ghosh
Nutrition in gastrointestinal (GI) cancer is an important part of treatment protocol. A detailed study of published guidelines is necessary to prevent pre-operative malnutrition and sustain peri-operative nutrition in such patients. In this review, we discuss and propose guidelines and recommendations based on established guidelines to suit the Indian population with different GI cancers (gastric, esophageal, pancreatic, colorectal and hepatocellular cancers). Keywords: GI cancer, Nutrition, Enteral nutrition, Parenteral nutrition, Immunonutrition
{"title":"Nutrition in GI Cancer : A Review","authors":"Shahana Gupta, S. Ghosh","doi":"10.55289/jnutres/v11i1_23.3","DOIUrl":"https://doi.org/10.55289/jnutres/v11i1_23.3","url":null,"abstract":"Nutrition in gastrointestinal (GI) cancer is an important part of treatment protocol. A detailed study of published guidelines is necessary to prevent pre-operative malnutrition and sustain peri-operative nutrition in such patients. In this review, we discuss and propose guidelines and recommendations based on established guidelines to suit the Indian population with different GI cancers (gastric, esophageal, pancreatic, colorectal and hepatocellular cancers). Keywords: GI cancer, Nutrition, Enteral nutrition, Parenteral nutrition, Immunonutrition","PeriodicalId":16096,"journal":{"name":"Journal of Food and Nutrition Research","volume":"255 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76345945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-15DOI: 10.55289/jnutres/v11i1_23.1
S. Timmanpyati, B. R. Reddy, Sunitha Premalatha, A. Rajeswari, Prasanthi Suryanaryana, Sai Sankalp Naidu, Bhakti Samant
Nutritional status plays an important role in cancer treatment. Several studies have strongly indicated that malnutrition has a negative impact on the efficacy of cancer treatment. Nutritional negligence or poor nutrition may impede the progress in cancer care, rendering them a harder time with the toxic side effects. It is well documented that there is a high prevalence of cancer-related malnutrition ranging from 25% to 70% from various studies, and cancer patients are the most malnourished of all other patient groups. Escalation of nutrients, effective counseling, and consistent monitoring as an adjuvant to cancer treatment, not only improve nutrition parameters, and body composition but also help in managing toxic effects, thus enhancing the quality of life and ultimately better survival. Keywords: Cancer nutrition, Onconutrition, Malnutrition
{"title":"A Panel Discussion in Nutritional Management in Cancer Care","authors":"S. Timmanpyati, B. R. Reddy, Sunitha Premalatha, A. Rajeswari, Prasanthi Suryanaryana, Sai Sankalp Naidu, Bhakti Samant","doi":"10.55289/jnutres/v11i1_23.1","DOIUrl":"https://doi.org/10.55289/jnutres/v11i1_23.1","url":null,"abstract":"Nutritional status plays an important role in cancer treatment. Several studies have strongly indicated that malnutrition has a negative impact on the efficacy of cancer treatment. Nutritional negligence or poor nutrition may impede the progress in cancer care, rendering them a harder time with the toxic side effects. It is well documented that there is a high prevalence of cancer-related malnutrition ranging from 25% to 70% from various studies, and cancer patients are the most malnourished of all other patient groups. Escalation of nutrients, effective counseling, and consistent monitoring as an adjuvant to cancer treatment, not only improve nutrition parameters, and body composition but also help in managing toxic effects, thus enhancing the quality of life and ultimately better survival. Keywords: Cancer nutrition, Onconutrition, Malnutrition","PeriodicalId":16096,"journal":{"name":"Journal of Food and Nutrition Research","volume":"16 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81768506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-15DOI: 10.55289/jnutres/v11i1_22.27
S. Timmanpyati, Shilpa Varma, B. Pottakkat, P. Vijayakumar, L. Sreedharan, Datta Patel, Mansi Patil, Sreemathy Venkatraman, Sanghamitra Chakravarti, Ritika Samaddar, Anshu Mehra
Malnutrition can be defined as a state of nutrition in which a deficiency or excess or imbalance of energy, protein, and other nutrients cause measurable adverse effects on body tissues, eventually affecting the quality of life and clinical outcome. Malnutrition is associated with many adverse outcomes both in the community as well as in clinical settings; including a suppressed immune system, impaired wound healing, muscle wasting, extended periods of hospital stay, and increased mortality. Undetected malnutrition not only enhances the risk of adverse complications for patients but impacts negatively with an increase in health care costs. This can be prevented if protocol prioritized attention is given to their nutritional care. Achievement of good nutrition is important and is a must in overall healthcare, hence, all stakeholders should be updated regarding the management of malnutrition and challenges encountered. It’s time we start, mobilize everyone and engage governments, policymakers, gain national and global cooperation to address the issue of malnutrition in healthcare settings. The objective of this specialist declaration is to provide evidence-based recommendations for the proper management of malnutrition by a multi-parametric approach starting with the screening of all patients by trained healthcare professionals with easy-to-use validated screening tools. Nutrition screening is the first step towards identifying patients at risk and requiring intervention at the earliest. Only a few accredited hospitals have nutrition screening at the time of reporting as a protocol. The timing of recognizing the presence of malnutrition or at-risk is of paramount importance to reverse the deteriorating nutritional status before the patient becomes cachectic. Keywords: Nutrition care, Malnutrition, Prevention, Clinical nutrition, Human right to nutrition care, Screening, Assessment, Dietitian
{"title":"The IAPEN INDIA Association for Parenteral and Enteral Nutrition Chennai Declaration on the Fundamental Right to Nutritional Care of Patients Under Treatment","authors":"S. Timmanpyati, Shilpa Varma, B. Pottakkat, P. Vijayakumar, L. Sreedharan, Datta Patel, Mansi Patil, Sreemathy Venkatraman, Sanghamitra Chakravarti, Ritika Samaddar, Anshu Mehra","doi":"10.55289/jnutres/v11i1_22.27","DOIUrl":"https://doi.org/10.55289/jnutres/v11i1_22.27","url":null,"abstract":"Malnutrition can be defined as a state of nutrition in which a deficiency or excess or imbalance of energy, protein, and other nutrients cause measurable adverse effects on body tissues, eventually affecting the quality of life and clinical outcome. Malnutrition is associated with many adverse outcomes both in the community as well as in clinical settings; including a suppressed immune system, impaired wound healing, muscle wasting, extended periods of hospital stay, and increased mortality. Undetected malnutrition not only enhances the risk of adverse complications for patients but impacts negatively with an increase in health care costs. This can be prevented if protocol prioritized attention is given to their nutritional care. Achievement of good nutrition is important and is a must in overall healthcare, hence, all stakeholders should be updated regarding the management of malnutrition and challenges encountered. It’s time we start, mobilize everyone and engage governments, policymakers, gain national and global cooperation to address the issue of malnutrition in healthcare settings. The objective of this specialist declaration is to provide evidence-based recommendations for the proper management of malnutrition by a multi-parametric approach starting with the screening of all patients by trained healthcare professionals with easy-to-use validated screening tools. Nutrition screening is the first step towards identifying patients at risk and requiring intervention at the earliest. Only a few accredited hospitals have nutrition screening at the time of reporting as a protocol. The timing of recognizing the presence of malnutrition or at-risk is of paramount importance to reverse the deteriorating nutritional status before the patient becomes cachectic. Keywords: Nutrition care, Malnutrition, Prevention, Clinical nutrition, Human right to nutrition care, Screening, Assessment, Dietitian","PeriodicalId":16096,"journal":{"name":"Journal of Food and Nutrition Research","volume":"15 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78315709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tian Tian, Yao Sun, Wenjie Zhu, Xiao-chen Gao, Li-wen Tang
In order to prepare a zinc nutritional fortifier which was easily absorbed by human body and improved the utilization rate of sika deer blood. In this research, response surface methodology (RSM) was used to optimize the preparation conditions of zinc chelate sika deer blood polypeptide (SDBP). The peak chelated rate was 82.1% and zinc content was 21.3mg/mL. Used deer blood and zinc sulfate as raw materials and zinc chelated rate as an indicator, the effect of pH, reaction time, peptide zinc mass ratio and reaction temperature on zinc chelating rate were investigated by single factor text. The optimal condition for the chelation reaction was that mass ratio of peptide: zinc 2:1, pH 6 and 60°C for 60 min. The structure of zinc chelated by SDBP was characterized by UV, FTIR, SEM, molecular weight and particle size analysis elt. FTIR proved that SDBPCZ had sufficient metal binding sites. The bioavailability of zinc ion in sika deer blood peptide chelated zinc(SDBPCZ) was determined by simulating gastrointestinal digestion and absorption in vitro. Experimental synthesis showed that SDBPCZ exhibited better zinc solubility and had higher dialyzable than ZnSO 4. These results might provide insights into the methods for developing functional foods such as zinc-fortified.
{"title":"Preparation and Cellular Absorption of Zinc-chelating Peptides Derived from Sika Deer Blood","authors":"Tian Tian, Yao Sun, Wenjie Zhu, Xiao-chen Gao, Li-wen Tang","doi":"10.12691/jfnr-11-1-8","DOIUrl":"https://doi.org/10.12691/jfnr-11-1-8","url":null,"abstract":"In order to prepare a zinc nutritional fortifier which was easily absorbed by human body and improved the utilization rate of sika deer blood. In this research, response surface methodology (RSM) was used to optimize the preparation conditions of zinc chelate sika deer blood polypeptide (SDBP). The peak chelated rate was 82.1% and zinc content was 21.3mg/mL. Used deer blood and zinc sulfate as raw materials and zinc chelated rate as an indicator, the effect of pH, reaction time, peptide zinc mass ratio and reaction temperature on zinc chelating rate were investigated by single factor text. The optimal condition for the chelation reaction was that mass ratio of peptide: zinc 2:1, pH 6 and 60°C for 60 min. The structure of zinc chelated by SDBP was characterized by UV, FTIR, SEM, molecular weight and particle size analysis elt. FTIR proved that SDBPCZ had sufficient metal binding sites. The bioavailability of zinc ion in sika deer blood peptide chelated zinc(SDBPCZ) was determined by simulating gastrointestinal digestion and absorption in vitro. Experimental synthesis showed that SDBPCZ exhibited better zinc solubility and had higher dialyzable than ZnSO 4. These results might provide insights into the methods for developing functional foods such as zinc-fortified.","PeriodicalId":16096,"journal":{"name":"Journal of Food and Nutrition Research","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47732233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaiyuan Cui, Zhijun Qiang, Rongzhen Wang, P. Ding, A. Ren, Linghong Li, H. Noor, Xiangyun Wu, Min Sun, Z. Gao
.
{"title":"Quinoa (Chenopodium quinoa Willd.) Genome-Wide Analysis of Glutathione S-transferase (CqGSTs) and Transcription Factor bHLH Family Study on Their Salt Tolerance Function","authors":"Kaiyuan Cui, Zhijun Qiang, Rongzhen Wang, P. Ding, A. Ren, Linghong Li, H. Noor, Xiangyun Wu, Min Sun, Z. Gao","doi":"10.12691/jfnr-11-1-7","DOIUrl":"https://doi.org/10.12691/jfnr-11-1-7","url":null,"abstract":".","PeriodicalId":16096,"journal":{"name":"Journal of Food and Nutrition Research","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42995642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shen Hui Yong, H. Noor, Dang Dexuan, Gao Haiyan, Liu Peng, Zhang Yuan qing, Cheng Qingjun
The Sweet sorghum ( Sorghum bicolor L.) Moench is a variant of grain sorghum, which origins in Africa. Due to its high sugar and tolerance, it has been considered as a potentially useful energy crop and received more attention. However, less study on sweet sorghum has been performed in physiology and molecular by Al stress. These results illustrated that the decrease of β-1,3-glucanase activity by Al could lead to callose accumulation. In POTCHETSTRM, five β-1,3-glucanase genes expression were up-regulated, and a gene expression was down-regulated. In ROMA, only one β-1,3-glucanase gene, SbGlu1 ( Sb03g045630.1 ) expressed response to Al, and the expression was higher in ROMA than in POTCHETSTRM. The expression levels of six callose synthase-like genes were very low exposure of 10 µM Al upon to 24 h in ROMA, but POTCHETSTRM exhibited the highest expression level only at 24 h. Therefore, callose synthase-like genes maybe regulate callose deposition in the later stage of Al stress in sweet sorghum. The SbGlu1 expression positively correlated with callose content in both cultivars. The SbGlu1 expression maybe involve in callose degradation in sweet sorghum by Al stress. The full-length cDNAs of SbGlu1 were cloned from the root tips of both ROMA and POTCHETSTRM, respectively. The SbGlu1 were transient expressed in onion epidermal cells for subcellular localization, showed that SbGLU1 is soluble with no specificity localization.
{"title":"Sweet Sorghum (Sorghum bicolor L.) Cloning and Functional Analysis of Callose Gene SbGlu1 in Protein Content","authors":"Shen Hui Yong, H. Noor, Dang Dexuan, Gao Haiyan, Liu Peng, Zhang Yuan qing, Cheng Qingjun","doi":"10.12691/jfnr-11-1-5","DOIUrl":"https://doi.org/10.12691/jfnr-11-1-5","url":null,"abstract":"The Sweet sorghum ( Sorghum bicolor L.) Moench is a variant of grain sorghum, which origins in Africa. Due to its high sugar and tolerance, it has been considered as a potentially useful energy crop and received more attention. However, less study on sweet sorghum has been performed in physiology and molecular by Al stress. These results illustrated that the decrease of β-1,3-glucanase activity by Al could lead to callose accumulation. In POTCHETSTRM, five β-1,3-glucanase genes expression were up-regulated, and a gene expression was down-regulated. In ROMA, only one β-1,3-glucanase gene, SbGlu1 ( Sb03g045630.1 ) expressed response to Al, and the expression was higher in ROMA than in POTCHETSTRM. The expression levels of six callose synthase-like genes were very low exposure of 10 µM Al upon to 24 h in ROMA, but POTCHETSTRM exhibited the highest expression level only at 24 h. Therefore, callose synthase-like genes maybe regulate callose deposition in the later stage of Al stress in sweet sorghum. The SbGlu1 expression positively correlated with callose content in both cultivars. The SbGlu1 expression maybe involve in callose degradation in sweet sorghum by Al stress. The full-length cDNAs of SbGlu1 were cloned from the root tips of both ROMA and POTCHETSTRM, respectively. The SbGlu1 were transient expressed in onion epidermal cells for subcellular localization, showed that SbGLU1 is soluble with no specificity localization.","PeriodicalId":16096,"journal":{"name":"Journal of Food and Nutrition Research","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44698889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Umar Ijaz, Tahreem Fatima, Moazama Batool, R. Azmat, A. Sadaf, Namra Ghafoor, Mehrab Khalil
Doxorubicin (DOX) is a commonly prescribed, potent anti-cancer drug, however, its clinical administration is restricted due to its serious organotoxic potential especially hepatotoxicity. Chrysoeriol (CSR) is a natural flavonoid, which exhibits putative antioxidant and free-radical scavenging activities. This research was planned to assess the hepatoprotective potential of CSR against DOX-prompted hepatic damage in male albino rats. 48 rats were segregated into four group viz. Control, DOX-treated group (3 mgkg -1 ), DOX + CSR-treated group (3 mgkg -1 + 20 mgkg -1 ) and CSR-treated group (20 mgkg -1 ). DOX treatment induced liver toxicity as indicated by the significant elevation in the serum levels of alanine aminotransferase (ALT) alkaline phosphatase (ALP), and aspartate aminotransferase (AST). Additionally, DOX exposure disrupted the biochemical profile by decreasing the activities of antioxidant enzymes i.e., catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione (GSH), glutathione reductase (GSR) and glutathione S-transferase (GST), while raised the levels of ROS and MDA. Furthermore, inflammatory markers level such as nuclear factor kappa B (NF-κB), tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6) as well as Cyclooxygenase-2 (COX-2) activity were also increased. Besides the level of pro-apoptotic markers i.e., Bax, Caspase-3 and Caspase-9 were raised, while the level of anti-apoptotic protein, Bcl-2 was reduced following the DOX intoxication. In DOX-treated rats, Histopathological observation indicated substantial hepatic tissue damage. However co-treatment with chrysoeriol remarkably reversed all the aforementioned hepatic damages. CSR demonstrated promising hepatoprotective potential through exerting antioxidant, anti-inflammatory and anti-apoptotic properties.
{"title":"Therapeutic Efficacy of Chrysoeriol on Doxorubicin-induced Liver Damage by Improving Biochemical and Histological Profile in Rats","authors":"Muhammad Umar Ijaz, Tahreem Fatima, Moazama Batool, R. Azmat, A. Sadaf, Namra Ghafoor, Mehrab Khalil","doi":"10.12691/jfnr-11-1-6","DOIUrl":"https://doi.org/10.12691/jfnr-11-1-6","url":null,"abstract":"Doxorubicin (DOX) is a commonly prescribed, potent anti-cancer drug, however, its clinical administration is restricted due to its serious organotoxic potential especially hepatotoxicity. Chrysoeriol (CSR) is a natural flavonoid, which exhibits putative antioxidant and free-radical scavenging activities. This research was planned to assess the hepatoprotective potential of CSR against DOX-prompted hepatic damage in male albino rats. 48 rats were segregated into four group viz. Control, DOX-treated group (3 mgkg -1 ), DOX + CSR-treated group (3 mgkg -1 + 20 mgkg -1 ) and CSR-treated group (20 mgkg -1 ). DOX treatment induced liver toxicity as indicated by the significant elevation in the serum levels of alanine aminotransferase (ALT) alkaline phosphatase (ALP), and aspartate aminotransferase (AST). Additionally, DOX exposure disrupted the biochemical profile by decreasing the activities of antioxidant enzymes i.e., catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione (GSH), glutathione reductase (GSR) and glutathione S-transferase (GST), while raised the levels of ROS and MDA. Furthermore, inflammatory markers level such as nuclear factor kappa B (NF-κB), tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6) as well as Cyclooxygenase-2 (COX-2) activity were also increased. Besides the level of pro-apoptotic markers i.e., Bax, Caspase-3 and Caspase-9 were raised, while the level of anti-apoptotic protein, Bcl-2 was reduced following the DOX intoxication. In DOX-treated rats, Histopathological observation indicated substantial hepatic tissue damage. However co-treatment with chrysoeriol remarkably reversed all the aforementioned hepatic damages. CSR demonstrated promising hepatoprotective potential through exerting antioxidant, anti-inflammatory and anti-apoptotic properties.","PeriodicalId":16096,"journal":{"name":"Journal of Food and Nutrition Research","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46605631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Different Variety and Phosphorus Fertilizer Applications on Grain Starch Characteristic and Nutrient Composition of Winter (Triticum aestivum L.) in Shanxi Province Taigu China","authors":"Shurong Wang, H. Noor, Zhili Guo","doi":"10.12691/jfnr-11-1-4","DOIUrl":"https://doi.org/10.12691/jfnr-11-1-4","url":null,"abstract":"","PeriodicalId":16096,"journal":{"name":"Journal of Food and Nutrition Research","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49172874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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