Pub Date : 2022-01-14DOI: 10.5614/j.math.fund.sci.2021.53.3.9
Cindy Cindy, Cynthia Cynthia, V. Vito, Devvi Sarwinda, B. Handari, G. Hertono
In Indonesia, Dengue incidence tends to increase every year but has been fluctuating in recent years. The potential for Dengue outbreaks in DKI Jakarta, the capital city, deserves serious attention. Weather factors are suspected of being associated with the incidence of Dengue in Indonesia. This research used weather and Dengue incidence data for five regions of DKI Jakarta, Indonesia, from December 30, 2008, to January 2, 2017. The study used a clustering approach on time-series and non-time-series data using K-Medoids and Fuzzy C-Means Clustering. The clustering results for the non-time-series data showed a positive correlation between the number of Dengue incidents and both average relative humidity and amount of rainfall. However, Dengue incidence and average temperature were negatively correlated. Moreover, the clustering implementation on the time-series data showed that rainfall patterns most closely resembled those of Dengue incidence. Therefore, rainfall can be used to estimate Dengue incidence. Both results suggest that the government could utilize weather data to predict possible spikes in DHF incidence, especially when entering the rainy season and alert the public to greater probability of a Dengue outbreak.
{"title":"Cluster Analysis on Dengue Incidence and Weather Data Using K-Medoids and Fuzzy C-Means Clustering Algorithms (Case Study: Spread of Dengue in the DKI Jakarta Province)","authors":"Cindy Cindy, Cynthia Cynthia, V. Vito, Devvi Sarwinda, B. Handari, G. Hertono","doi":"10.5614/j.math.fund.sci.2021.53.3.9","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2021.53.3.9","url":null,"abstract":"In Indonesia, Dengue incidence tends to increase every year but has been fluctuating in recent years. The potential for Dengue outbreaks in DKI Jakarta, the capital city, deserves serious attention. Weather factors are suspected of being associated with the incidence of Dengue in Indonesia. This research used weather and Dengue incidence data for five regions of DKI Jakarta, Indonesia, from December 30, 2008, to January 2, 2017. The study used a clustering approach on time-series and non-time-series data using K-Medoids and Fuzzy C-Means Clustering. The clustering results for the non-time-series data showed a positive correlation between the number of Dengue incidents and both average relative humidity and amount of rainfall. However, Dengue incidence and average temperature were negatively correlated. Moreover, the clustering implementation on the time-series data showed that rainfall patterns most closely resembled those of Dengue incidence. Therefore, rainfall can be used to estimate Dengue incidence. Both results suggest that the government could utilize weather data to predict possible spikes in DHF incidence, especially when entering the rainy season and alert the public to greater probability of a Dengue outbreak.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78633501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.5614/j.math.fund.sci.2021.53.3.8
D. H. Tjahjono, B. L. Sari, Slamet Ibrahim
The urokinase-type plasminogen activator (uPA) system plays a significant role in the invasion and metastasis of cancer cells. The present study was conducted to investigate natural product compounds as inhibitors and hit molecules of uPA using in-silico analysis. A pharmacophore model was built to screen the Indonesian Herbal Database (HerbalDB) to obtain inhibitors of different scaffolds. Based on the molecular docking score, four ligands were selected as potential uPA inhibitors. Subsequently, the stability of the ligand-uPA complex was analyzed using molecular dynamics (MD) simulation. An RMSD graph of the backbone protein and the RMSF values of the amino acid residues were also determined. In addition, the MM-PBSA method was applied to calculate the free binding energy. According to the results, Model_3, characterized by aromatic rings 23 (F1 and F2), cationic H-bond donor (F3), and metal ligator (F4) features, had an adequate goodness-of-hit score (GH). The four top-ranked ligands, isorhamnetin, rhamnetin, quercetin, and kaempferol, showed higher docking scores compared to the others. This study confirmed that isorhamnetin, rhamnetin, and kaempferol build stable complexes with uPA with lower binding energy than quercetin.
{"title":"Pharmacophore Modeling, Docking, and Molecular Dynamics Simulation of Flavonoids as Inhibitors of Urokinase-type Plasminogen Activator","authors":"D. H. Tjahjono, B. L. Sari, Slamet Ibrahim","doi":"10.5614/j.math.fund.sci.2021.53.3.8","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2021.53.3.8","url":null,"abstract":"The urokinase-type plasminogen activator (uPA) system plays a significant role in the invasion and metastasis of cancer cells. The present study was conducted to investigate natural product compounds as inhibitors and hit molecules of uPA using in-silico analysis. A pharmacophore model was built to screen the Indonesian Herbal Database (HerbalDB) to obtain inhibitors of different scaffolds. Based on the molecular docking score, four ligands were selected as potential uPA inhibitors. Subsequently, the stability of the ligand-uPA complex was analyzed using molecular dynamics (MD) simulation. An RMSD graph of the backbone protein and the RMSF values of the amino acid residues were also determined. In addition, the MM-PBSA method was applied to calculate the free binding energy. According to the results, Model_3, characterized by aromatic rings 23 (F1 and F2), cationic H-bond donor (F3), and metal ligator (F4) features, had an adequate goodness-of-hit score (GH). The four top-ranked ligands, isorhamnetin, rhamnetin, quercetin, and kaempferol, showed higher docking scores compared to the others. This study confirmed that isorhamnetin, rhamnetin, and kaempferol build stable complexes with uPA with lower binding energy than quercetin.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"70 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90667734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-15DOI: 10.5614/j.math.fund.sci.2021.53.3.6
A. Barlian, M. Tan, Ergha Widya Sarjana, N. Vanawati
Previous research has proven that 10% platelet-rich plasma (PRP) can enhance growth and differentiation of human adipose derived stem cells (hADSC) grown on silk fibroin scaffold into chondrocytes. A low oxygen concentration (hypoxia) condition is an important factor that potentially affects the ability of hADSC to grow and differentiate. The objective of this research was to analyze the difference in growth and differentiation capacity of hADSC grown on salt leached silk fibroin scaffold supplemented by 10% PRP under normoxic and hypoxic conditions. The growth capacity of the hADSC was determined by MTT assay and differentiation was tested using glycosaminoglycan (GAG) content analysis, while chondrocyte markers were visualized with the immunocytochemistry (ICC) method. This research observed hADSC proliferation under normoxic and hypoxic conditions for 21 days. Visualization of type 2 collagen showed that it was more abundant under hypoxia compared to normoxia. HIF-1α was only detected in the hADSC cultured in hypoxic conditions. In conclusion, culture under hypoxic conditions increases the capacity of hADSC to grow and differentiate into chondrocytes. This is the first study that has shown that hypoxia is able to enhance the proliferation and differentiation of hADSC grown on 3D salt leached silk fibroin scaffold supplemented by 10% PRP.
{"title":"Role of Hypoxia on Growth and Differentiation of Human Adipose Derived Stem Cells Grown on Silk Fibroin Scaffold Induced by Platelet Rich Plasma","authors":"A. Barlian, M. Tan, Ergha Widya Sarjana, N. Vanawati","doi":"10.5614/j.math.fund.sci.2021.53.3.6","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2021.53.3.6","url":null,"abstract":"Previous research has proven that 10% platelet-rich plasma (PRP) can enhance growth and differentiation of human adipose derived stem cells (hADSC) grown on silk fibroin scaffold into chondrocytes. A low oxygen concentration (hypoxia) condition is an important factor that potentially affects the ability of hADSC to grow and differentiate. The objective of this research was to analyze the difference in growth and differentiation capacity of hADSC grown on salt leached silk fibroin scaffold supplemented by 10% PRP under normoxic and hypoxic conditions. The growth capacity of the hADSC was determined by MTT assay and differentiation was tested using glycosaminoglycan (GAG) content analysis, while chondrocyte markers were visualized with the immunocytochemistry (ICC) method. This research observed hADSC proliferation under normoxic and hypoxic conditions for 21 days. Visualization of type 2 collagen showed that it was more abundant under hypoxia compared to normoxia. HIF-1α was only detected in the hADSC cultured in hypoxic conditions. In conclusion, culture under hypoxic conditions increases the capacity of hADSC to grow and differentiate into chondrocytes. This is the first study that has shown that hypoxia is able to enhance the proliferation and differentiation of hADSC grown on 3D salt leached silk fibroin scaffold supplemented by 10% PRP.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"82 6 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89587667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-14DOI: 10.5614/j.math.fund.sci.2021.53.3.5
O. Makinde, A. S. Eegunjobi
This work investigated the thermal putrefaction and inherent irreversibility in a steady flow of an incompressible inconstant viscosity radiating fluid within two concentric pipes filled with a porous medium. Following the Brinkmann-Darcy-Forchheimer approach, the nonlinear differential equations governing the model were obtained. The model boundary value problem was addressed numerically via a shooting quadrature with the Runge-Kutta-Fehlberg integration scheme. The effects of diverse emerging parameters on the fluid velocity, temperature, skin friction, Nusselt number, entropy generation rate and the Bejan number are provided in graphs and discussed in this paper.
{"title":"Inherent Irreversibility of Mixed Convection within Concentric Pipes in a Porous Medium with Thermal Radiation","authors":"O. Makinde, A. S. Eegunjobi","doi":"10.5614/j.math.fund.sci.2021.53.3.5","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2021.53.3.5","url":null,"abstract":"This work investigated the thermal putrefaction and inherent irreversibility in a steady flow of an incompressible inconstant viscosity radiating fluid within two concentric pipes filled with a porous medium. Following the Brinkmann-Darcy-Forchheimer approach, the nonlinear differential equations governing the model were obtained. The model boundary value problem was addressed numerically via a shooting quadrature with the Runge-Kutta-Fehlberg integration scheme. The effects of diverse emerging parameters on the fluid velocity, temperature, skin friction, Nusselt number, entropy generation rate and the Bejan number are provided in graphs and discussed in this paper.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2021-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76037153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-03DOI: 10.5614/j.math.fund.sci.2021.53.3.4
Nur Ilmayasinta, Heri Purnawan
This paper presents a dynamic model of smoking with optimal control. The mathematical model is divided into 5 sub-classes, namely, non-smokers, occasional smokers, active smokers, individuals who have temporarily stopped smoking, and individuals who have stopped smoking permanently. Four optimal controls, i.e., anti-smoking education campaign, anti-smoking gum, anti-nicotine drug, and government prohibition of smoking in public spaces are considered in the model. The existence of the controls is also presented. The Pontryagin maximum principle (PMP) was used to solve the optimal control problem. The fourth-order Runge-Kutta was employed to gain the numerical solutions.
{"title":"Optimal Control in a Mathematical Model of Smoking","authors":"Nur Ilmayasinta, Heri Purnawan","doi":"10.5614/j.math.fund.sci.2021.53.3.4","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2021.53.3.4","url":null,"abstract":"This paper presents a dynamic model of smoking with optimal control. The mathematical model is divided into 5 sub-classes, namely, non-smokers, occasional smokers, active smokers, individuals who have temporarily stopped smoking, and individuals who have stopped smoking permanently. Four optimal controls, i.e., anti-smoking education campaign, anti-smoking gum, anti-nicotine drug, and government prohibition of smoking in public spaces are considered in the model. The existence of the controls is also presented. The Pontryagin maximum principle (PMP) was used to solve the optimal control problem. The fourth-order Runge-Kutta was employed to gain the numerical solutions.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85961930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-03DOI: 10.5614/j.math.fund.sci.2021.53.3.3
A. Pradipto, K. Nakamura
The intrinsic spin Hall effect in the bulk systems of late transition metals (Os, Ir, Pt, and Au) as well as the Pt-based superlattices were investigated by using first-principle calculations. By comparing the computed spin Hall conductivities of Pt−M superlattices (M=Os, Ir, and Au) with different compositions and those obtained from atomic bulk composition, we saw that the spin Hall conductivities (SHCs) follow the behavior described by the Slater-Pauling curve, the maximum of which is at pure Pt bulk. From the examination of the band structures of the considered systems, we found that the origin of this behavior comes from the variation of the band structures as a direct consequence of the change of the number of electrons and hybridization effects.
利用第一性原理计算研究了迟过渡金属(Os, Ir, Pt和Au)体系以及Pt基超晶格中的本征自旋霍尔效应。通过比较不同组成的Pt−M超晶格(M=Os, Ir和Au)的自旋霍尔电导率与原子体组成的自旋霍尔电导率的计算结果，我们发现自旋霍尔电导率(SHCs)遵循Slater-Pauling曲线所描述的行为，其最大值出现在纯Pt体。通过对所考虑的体系的能带结构的研究，我们发现这种行为的起源是由于电子数和杂化效应的变化直接导致了能带结构的变化。
{"title":"Slater-Pauling-like Behavior of Spin Hall Conductivity in Pt-based Superlattices","authors":"A. Pradipto, K. Nakamura","doi":"10.5614/j.math.fund.sci.2021.53.3.3","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2021.53.3.3","url":null,"abstract":"The intrinsic spin Hall effect in the bulk systems of late transition metals (Os, Ir, Pt, and Au) as well as the Pt-based superlattices were investigated by using first-principle calculations. By comparing the computed spin Hall conductivities of Pt−M superlattices (M=Os, Ir, and Au) with different compositions and those obtained from atomic bulk composition, we saw that the spin Hall conductivities (SHCs) follow the behavior described by the Slater-Pauling curve, the maximum of which is at pure Pt bulk. From the examination of the band structures of the considered systems, we found that the origin of this behavior comes from the variation of the band structures as a direct consequence of the change of the number of electrons and hybridization effects.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89682785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-03DOI: 10.5614/j.math.fund.sci.2021.53.3.1
Sehah Sehah, H. Hartono, Z. Irayani, U. N. Prabowo
A geoelectric survey using the 1D-electrical resistivity method was applied to design a groundwater aquifer model for the banks of the Serayu River in Sokawera Village, Somagede District, Banyumas Regency, Indonesia. The aim of this research was to identify the characteristics of aquifers in the research area based on resistivity log data. Acquisition, modeling, and interpretation of resistivity data were carried out and the results were lithological logs at seven sounding points. Correlation between the lithological logs resulted in a hydrostratigraphic model. This model is composed of several hydrological units, i.e. shallow aquifer, aquitard, and deep aquifer. The shallow aquifers are composed of sandy clay (10.81-18.21 Wm) and clayey sand (3.04-7.43 Wm) with a depth of groundwater from the water table to 27.51 m. The deep aquifers are composed of sandstone with variation of porosity (2.24-12.04 Wm) at a depth of more than 54.98 m. Based on this model, potential shallow aquifers were estimated to be at sounding points Sch-5, Sch-6, and Sch-7. This hydrostratigraphic model shows that the two types of aquifers are separated by an aquitard layer, allowing groundwater infiltration from the shallow aquifer to the deep aquifer and vice versa. Moreover, the Serayu riverbanks in this research area are estimated to be a groundwater discharge area.
{"title":"Designing Aquifer Model for the Banks of the Serayu River, Sokawera, Somagede, Banyumas, Indonesia by Means of 1D-Electrical Resistivity Data","authors":"Sehah Sehah, H. Hartono, Z. Irayani, U. N. Prabowo","doi":"10.5614/j.math.fund.sci.2021.53.3.1","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2021.53.3.1","url":null,"abstract":"A geoelectric survey using the 1D-electrical resistivity method was applied to design a groundwater aquifer model for the banks of the Serayu River in Sokawera Village, Somagede District, Banyumas Regency, Indonesia. The aim of this research was to identify the characteristics of aquifers in the research area based on resistivity log data. Acquisition, modeling, and interpretation of resistivity data were carried out and the results were lithological logs at seven sounding points. Correlation between the lithological logs resulted in a hydrostratigraphic model. This model is composed of several hydrological units, i.e. shallow aquifer, aquitard, and deep aquifer. The shallow aquifers are composed of sandy clay (10.81-18.21 Wm) and clayey sand (3.04-7.43 Wm) with a depth of groundwater from the water table to 27.51 m. The deep aquifers are composed of sandstone with variation of porosity (2.24-12.04 Wm) at a depth of more than 54.98 m. Based on this model, potential shallow aquifers were estimated to be at sounding points Sch-5, Sch-6, and Sch-7. This hydrostratigraphic model shows that the two types of aquifers are separated by an aquitard layer, allowing groundwater infiltration from the shallow aquifer to the deep aquifer and vice versa. Moreover, the Serayu riverbanks in this research area are estimated to be a groundwater discharge area.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81768962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-19DOI: 10.20944/preprints202111.0355.v1
J. A. Fatkhurrahman, Puji Lestari
Nitrogen dioxide (NO2) contributes to several impacts both for human health and the environment. Periodical measurement of NO2 at industrial and residential areas needs comprehensive and reliable instrumentation; long-interference-free measures with minimum maintenance and re-calibration. DOAS can be used as a direct measurement technique based on specific absorption characteristics of NO2 follow Beer-Lambert law. This research applies a low-cost folded path photometer for measurement NO2 in air. Cheap tubular acrylic used as a detection cell with a 3D printed framework makes it compact, modular, and flexible. Evaluation of the DOAS conducted by instrument test responses using NO2 gas. The estimated LOD was ~ 1263 pb using 2 nm resolution of the spectrometer and 6-meter detection cell length. Deviation of the DOAS estimated to be 0.8% at high concentration and 2.85% at a low concentration based on DOAS calibration. An intercomparison between methods used to evaluate instrument performance to measure NO2 using emission from a motorcycle with coefficient correlation (R) 0.649 for paired DOAS-ASTM D1607 Griesz Saltzmann Method 0.846 for paired DOAS-Electrochemical Gas Analyzer. This significant correlation is caused by different respond time between paired methods, while it is still comparable for NO2 measurement.
{"title":"Evaluation NO2 Detection Using Low-Cost Folded Path Photometer","authors":"J. A. Fatkhurrahman, Puji Lestari","doi":"10.20944/preprints202111.0355.v1","DOIUrl":"https://doi.org/10.20944/preprints202111.0355.v1","url":null,"abstract":"Nitrogen dioxide (NO2) contributes to several impacts both for human health and the environment. Periodical measurement of NO2 at industrial and residential areas needs comprehensive and reliable instrumentation; long-interference-free measures with minimum maintenance and re-calibration. DOAS can be used as a direct measurement technique based on specific absorption characteristics of NO2 follow Beer-Lambert law. This research applies a low-cost folded path photometer for measurement NO2 in air. Cheap tubular acrylic used as a detection cell with a 3D printed framework makes it compact, modular, and flexible. Evaluation of the DOAS conducted by instrument test responses using NO2 gas. The estimated LOD was ~ 1263 pb using 2 nm resolution of the spectrometer and 6-meter detection cell length. Deviation of the DOAS estimated to be 0.8% at high concentration and 2.85% at a low concentration based on DOAS calibration. An intercomparison between methods used to evaluate instrument performance to measure NO2 using emission from a motorcycle with coefficient correlation (R) 0.649 for paired DOAS-ASTM D1607 Griesz Saltzmann Method 0.846 for paired DOAS-Electrochemical Gas Analyzer. This significant correlation is caused by different respond time between paired methods, while it is still comparable for NO2 measurement.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85074861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-21DOI: 10.5614/j.math.fund.sci.2021.53.2.10
S. M. Nursatya, A. Barlian, H. Judawisastra, I. Wibowo, H. Tanoto
This study aimed to determine the characteristics of scaffolds made of fibroin from Bombyx mori and spidroin from Argiope appensa in supporting the attachment and proliferation of HDF cells on the scaffolds. Thin-film scaffolds were made using the solvent casting technique, where the scaffold is an amalgamation of fibroin, spidroin, PVA, and glycerol. HDF cells were grown on DMEM medium with 10% FBS and 1% antibiotic-antimicotic. Characterization of the scaffolds was performed by using ATR-FTIR, swelling test, contact angle measurement, tensile test, biodegradation, MTT and SEM. The results of the ATR-FTIR analysis showed that the scaffolds contained fibroin, spidroin, PVA, and glycerol. Swelling and contact angle tests showed that all scaffold combinations were hydrophilic. Mechanical properties and in vitro biodegradation tests showed no significant difference among the scaffold combinations. MTT testing showed that all scaffolds could facilitate the attachment of fibroblasts and showed increased viability from day 1, 3, and 5. Scanning electron microscopy showed that the cells in the 70% fibroin and 10% spidroin scaffold had the best cell morphology and the best combination for potential application in skin tissue engineering.
{"title":"Fibroin and Spidroin Thin Film to Support the Attachment and Spread of Human Dermal Fibroblast: The Potency of Skin Tissue Engineering","authors":"S. M. Nursatya, A. Barlian, H. Judawisastra, I. Wibowo, H. Tanoto","doi":"10.5614/j.math.fund.sci.2021.53.2.10","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2021.53.2.10","url":null,"abstract":"This study aimed to determine the characteristics of scaffolds made of fibroin from Bombyx mori and spidroin from Argiope appensa in supporting the attachment and proliferation of HDF cells on the scaffolds. Thin-film scaffolds were made using the solvent casting technique, where the scaffold is an amalgamation of fibroin, spidroin, PVA, and glycerol. HDF cells were grown on DMEM medium with 10% FBS and 1% antibiotic-antimicotic. Characterization of the scaffolds was performed by using ATR-FTIR, swelling test, contact angle measurement, tensile test, biodegradation, MTT and SEM. The results of the ATR-FTIR analysis showed that the scaffolds contained fibroin, spidroin, PVA, and glycerol. Swelling and contact angle tests showed that all scaffold combinations were hydrophilic. Mechanical properties and in vitro biodegradation tests showed no significant difference among the scaffold combinations. MTT testing showed that all scaffolds could facilitate the attachment of fibroblasts and showed increased viability from day 1, 3, and 5. Scanning electron microscopy showed that the cells in the 70% fibroin and 10% spidroin scaffold had the best cell morphology and the best combination for potential application in skin tissue engineering.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85633835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-12DOI: 10.5614/j.math.fund.sci.2021.53.2.8
Ery Arifullah, Y. Zaim, A. Aswan, Djuhaeni Djuhaeni
Ichnofossils are still not used in paleoecological studies, even though they are a valuable proxy for paleoecology. This study focused on a semi-quantitative approach to a number of ichnofabric variables, i.e. ichnofossil association, bioturbation index (BI), ichnodiversity (ID), number of behaviors (NB), penetration depth (PD), and burrow diameter (DM). It was proved that the scores of those variables were low to medium because of the paleoecological fluvial-marine transition depositional processes in the Serravallian-Tortonian interval in Kutai Basin, Indonesia. This paper contributes an ichnofabric model that is visualized as histograms. One histogram shows the most common ichnofossil associations found in ichnofabric units, i.e., Ophiomorpha, Skolithos, Paleophycus, Planolites, Thalassinoides, and Chondrites. The other histograms describe the ichnofabric variables scores for BI, ID, NB, PD, and DM. The variables represent low to medium scores, a characteristic of a brackish paleoecology at basin-scale, a unique indicator for the fluvial-marine transition depositional system.
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