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Backward Bifurcation Emerging from a Mathematical Model of African Animal Trypanosomiasis Disease in White Rhino Populations 非洲动物锥虫病在白犀牛种群中的数学模型的后向分叉
IF 0.7 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2022-09-12 DOI: 10.5614/j.math.fund.sci.2022.54.1.9
D. Aldila, Tama Windyhani
This paper introduces a mathematical model for African animal trypanosomiasis (AAT) in white rhino and tsetse fly populations. The model accommodates two types of interventions, namely infection detection and ground spraying. The dynamical system properties were thoroughly investigated to show the existence of equilibrium points, backward bifurcation, and how they are related to the basic reproduction number. We found that there is a chance that AAT may die out from the population if the basic reproduction number is smaller than one. However, the possible existence of backward bifurcation implies a condition where we may have a stable endemic equilibrium, even when the basic reproduction number is smaller than one. Hence, the basic reproduction number is no longer sufficient to guarantee the disappearance of AAT from the population. Our sensitivity analysis on the basic reproduction number showed that the interventions of infection detection and ground spraying have good potential to eradicate AAT from the population. To analyze the most effective intervention as time-dependent variable, we reconstructed our model as an optimal control problem. Numerical simulations on various scenarios were conducted for the optimal control problem. Cost-effectiveness analysis using the Average Cost-Effectiveness Ratio (ACER) and the Incremental Cost-Effectiveness Ratio (ICER) methods was performed. From the cost-effectiveness analysis, we found that ground spraying is the most cost-effective intervention to combat the spread of AAT in white rhino populations.
本文介绍了非洲动物锥虫病(AAT)在白犀牛和采采蝇种群中的数学模型。该模型包含两种干预措施,即感染检测和地面喷洒。深入研究了动力学系统的性质,证明了平衡点、后向分叉的存在性,以及它们与基本再生数的关系。我们发现,如果基本繁殖数小于1,AAT就有可能从种群中灭绝。然而,后向分岔的可能存在意味着,即使基本繁殖数小于1,我们也可能有一个稳定的地方性平衡。因此,基本繁殖数不再足以保证AAT从种群中消失。对基本繁殖数的敏感性分析表明,感染检测和地面喷洒干预措施具有良好的种群根除潜力。为了分析最有效的干预作为时变变量,我们将模型重构为最优控制问题。对最优控制问题进行了各种情况下的数值模拟。采用平均成本-效果比(ACER)和增量成本-效果比(ICER)方法进行成本-效果分析。从成本效益分析中,我们发现地面喷洒是对抗AAT在白犀牛种群中传播的最具成本效益的干预措施。
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引用次数: 1
Basin Study in Atambua, West Timor, Indonesia from Gravity Data 印度尼西亚西帝汶Atambua盆地重力数据研究
IF 0.7 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2022-09-02 DOI: 10.5614/j.math.fund.sci.2022.54.1.8
Edy Wijanarko, I. Arisbaya, P. Sumintadireja, W. Warsa, H. Grandis
Timor Island, Indonesia has complex geological structures related to its tectonic history. There is an existing subsurface geological model that is based on geophysical data. It is limited to the regional crustal scale and has a relatively low spatial resolution. The objective of our study was to delineate the sedimentary basin configuration of the area, both laterally and vertically, based on gravity data. Spectral analysis of the Bouguer anomaly allowed for anomaly enhancement by wavenumber domain filtering. Two main basins were identified from elongated low gravity anomalies that follow a SW-NE trend, i.e., the Central Basin and the Atambua Basin. The 2½D gravity modeling of selected profiles perpendicular to the regional structural direction revealed the sedimentary fills of the basins and the basement based on their densities. The Bobonaro mélanges and Viqueque sequences dominate and overlay the syn-rift (Kekneno sequences) and post-rift (Kolbano sequences) with varying lithology. These para-autochthon sediments are dominated by shale and carbonaceous rocks. Their respective thicknesses and depths of burial imply the possibility of hydrocarbon generation. The underlying basement may be associated with the Australian crust protruding from the south.
印尼帝汶岛地质构造复杂,与其构造史有关。已有一种基于地球物理数据的地下地质模型。它仅限于区域地壳尺度,空间分辨率相对较低。我们的研究目的是根据重力数据,在横向和纵向上描绘该地区的沉积盆地结构。布格异常的频谱分析允许通过波数域滤波来增强异常。根据拉长的低重力异常,确定了两个主要盆地,即中央盆地和Atambua盆地,它们遵循SW-NE走向。选取垂直于区域构造方向的剖面进行2½D重力模拟,根据密度揭示了盆地和基底的沉积充填。Bobonaro msamulanges和Viqueque层序主导并覆盖了岩性不同的同裂谷(Kekneno层序)和后裂谷(Kolbano层序)。这些准本土沉积物以页岩和碳质岩为主。它们各自的埋藏厚度和深度暗示了生烃的可能性。下伏基底可能与澳大利亚地壳从南部突出有关。
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引用次数: 1
Flower Pollination and Elitism Algorithms for Inversion of TDEM Data TDEM数据反演中的花授粉和精英算法
IF 0.7 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2022-08-30 DOI: 10.5614/j.math.fund.sci.2022.54.1.7
Widodo Widodo, Farkhan Raflesia, Susanti Awaliyah, Setianingsih Setianingsih, D. Santoso, W. Parnadi, F. Fatkhan
Hybridization of algorithms can enhance the overall search capabilities to get the optimal solution. The aim of this study was to invert Time Domain Electromagnetic (TDEM) data using the Flower Pollination Algorithm (FPA) as a new inversion scheme technique. FPA was originally inspired by the fertilization process of flowers, in which pollen transfer grains from male flowers to female flowers. The modeling of TDEM data was done by combining the FPA and elitism (eFPA) techniques. The applicability was tested on forward modeling data and observed data in MATLAB 2017a. In testing the algorithm, we used a model from homogeneous half space to a multi-layer model using different parameters (resistivity and thickness). In addition, in the inversion process, we used field data with various starting model approaches. Based on the results of the TDEM data modeling, FPA and eFPA can both be applied as algorithmic techniques for inversion modeling of TDEM data. The eFPA technique gave better results than FPA.
混合算法可以增强整体搜索能力,从而得到最优解。本研究的目的是利用花授粉算法(FPA)作为一种新的反演方案技术对时域电磁(TDEM)数据进行反演。FPA最初的灵感来自于花的受精过程,即花粉粒从雄花转移到雌花。结合FPA和精英化(eFPA)技术对TDEM数据进行建模。在MATLAB 2017a中对正演建模数据和观测数据进行了适用性测试。在测试算法时,我们使用了使用不同参数(电阻率和厚度)从均匀半空间到多层模型的模型。此外,在反演过程中,我们使用了多种启动模型方法的现场数据。基于TDEM数据建模的结果,FPA和eFPA都可以作为TDEM数据反演建模的算法技术。eFPA技术优于FPA技术。
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引用次数: 2
Piper crocatum Ameliorates APAP-Induced Hepatotoxicity through Antioxidant and Anti-Inflammatory Mechanisms 番椒通过抗氧化和抗炎机制改善apap诱导的肝毒性
IF 0.7 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2022-06-21 DOI: 10.5614/j.math.fund.sci.2022.54.1.6
I. Lister, C. Ginting, Ermi Girsang, A. Amansyah, L. Chiuman, N. L. W. E. Yanti, W. Widodo, D. T. Yusepany, R. Rizal, W. Widowati
Cirrhosis is a serious hepatic disease that occurs worldwide and is caused by progressive fibrosis in the liver. Free radicals are the major cause of reactive oxygen species (ROS) generation, which affects the balance of the liver metabolism. Piper crocatum, commonly called red betel, is widely used in ethnomedicine because it has biological capabilities, including antioxidant and anti-inflammatory properties. The present study was undertaken to examine the possibility of hepaprotective activity of red betel extract on acetaminophen (APAP)-induced HepG2 cells as the cirrhosis in vitro model. Assessment of red betel extract (RBE) was performed using the colorimetric method for the quantification of LDH, AST, and ALT. As preliminary study, a cytotoxicity  assay was performed at various RBE concentrations (100.00; 50.00; 25.00; 12.50; 6.25; 3.13 μg/ml) using an MTS assay to decide the safe concentration based on cell viability. The RBE treatment did not affect cell viability, even at a high concentration (100 µg/ml, p > 0.05). RBE at concentrations 25 and 100 µg/ml successfully reduced LDH, AST, and ALT activities in the hepatotoxic model in a dose-dependent manner. In the APAP-induced hepatotoxicity model, RBE positively indicated a hepatoprotective effect and cell amelioration by a decrease in hepatotoxic markers.
肝硬化是一种严重的肝脏疾病,发生在世界各地,是由肝脏进行性纤维化引起的。自由基是活性氧(reactive oxygen species, ROS)产生的主要原因,影响肝脏代谢的平衡。藏红花,俗称红槟榔,因其具有抗氧化和抗炎等生物学特性而被广泛用于民族医学。本研究旨在探讨红槟榔提取物对对乙酰氨基酚(APAP)诱导的肝硬化HepG2细胞的肝保护作用。采用比色法定量测定LDH、AST和ALT,对红槟榔提取物(RBE)进行评估。作为初步研究,在不同浓度的RBE (100.00;50.00;25.00;12.50;6.25;3.13 μg/ml),采用MTS法根据细胞活力确定安全浓度。RBE处理即使在高浓度(100µg/ml, p > 0.05)下也不影响细胞活力。浓度为25和100µg/ml的RBE成功地降低了肝毒性模型中LDH、AST和ALT的活性,并呈剂量依赖性。在apap诱导的肝毒性模型中,RBE通过降低肝毒性标志物积极显示出肝保护作用和细胞改善作用。
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引用次数: 0
Trade Credit Policies for Supplier, Manufacturer, and Retailer: An Imperfect Production-Inventory System with Rework 供应商、制造商和零售商的贸易信用政策:一个有返工的不完善生产库存系统
IF 0.7 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2022-06-05 DOI: 10.5614/j.math.fund.sci.2022.54.1.5
A. Nigwal, U. Khedlekar, Leena Sharma, N. Gupta
In this study, we developed a trade credit policy for a three-layer supply chain consisting of a supplier, a manufacturer and a retailer. We propose an optimal production rate and selling price for the manufacturer and the retailer under an imperfect production system. The suggested coordination policy optimizes the profit of each supply chain member. Two models were formulated for two real-life strategies respectively. The first one is a collaborative (integrated) system and the second one is a Stackelberg leadership system. Both strategies were analyzed for various credit periods, respectively offered by the supplier to the manufacturer, by the manufacturer to the retailer, and by the retailer to the customers, by considering price-sensitive demand and a certain replenishment rate. Finally, we concluded which strategy will be better for inventory management under the given restrictions in the form of propositions. The concavity property for the net profit function was established with respect to the selling price and the production rate, which was also described graphically and analyzed by numerical examples.
在本研究中,我们针对由供应商、制造商和零售商组成的三层供应链制定了贸易信用政策。在不完善的生产系统下,给出了制造商和零售商的最优生产率和最优销售价格。所建议的协调策略使供应链各成员的利益最优。分别针对现实生活中的两种策略建立了两个模型。第一种是协作(集成)系统,第二种是Stackelberg领导系统。在考虑价格敏感需求和一定补货率的情况下,分别对供应商提供给制造商、制造商提供给零售商和零售商提供给顾客的不同信用期策略进行分析。最后以命题的形式总结出在给定限制条件下哪种策略更适合库存管理。建立了净利润函数相对于销售价格和生产率的凹性,并用图形描述和数值算例进行了分析。
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引用次数: 0
Vulnerability of Primary Productivity and Its Carbon Use Efficiency to Unfavorable Climatic Conditions in Jambi Province, Indonesia 印度尼西亚占碑省初级生产力及其碳利用效率对不利气候条件的脆弱性
IF 0.7 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2022-06-01 DOI: 10.5614/j.math.fund.sci.2022.54.1.4
U. Ma’rufah, T. June, Ashehad Ashween Ali, A. Faqih, Y. Koesmaryono, C. Stiegler, A. Knohl
Climatic conditions and land cover play crucial roles in influencing the process of carbon uptake through vegetation. This study aimed to analyze the effect of climate variability on carbon uptake of four different land covers in Jambi Province, Indonesia. The four land cover types studied were: forest, shrub, grass, and irrigated soybean, based on Community Land Model version 5. Forest was found to have the highest net primary production (NPP) compared to the other land covers. Seasonal climate variability showed no major effect on NPP and gross primary production (GPP). However, GPP and NPP experienced significant declines during El Niño Southern Oscillation (ENSO), particularly in 2015. Carbon use efficiency (CUE = NPP/GPP) was also affected by ENSO, where CUE decreased during El Niño, particularly in October and November with an increased number of days without rainfall. In addition, the difference between latent (LE) and sensible heat (H) flux, denoted as (LE-H), decreased from August to November. This difference was highly correlated with NPP. This result indicates that when water supply is low, stomata will close, thereby reducing photosynthesis and transpiration, and allocating more of the available energy to sensible heat flux rather than latent heat flux.
气候条件和土地覆盖在影响植被吸收碳的过程中起着至关重要的作用。本研究旨在分析气候变率对印度尼西亚占碑省四种不同土地覆盖的碳吸收的影响。基于社区土地模型第5版,研究了森林、灌木、草地和灌溉大豆四种土地覆盖类型。与其他土地覆盖相比,森林具有最高的净初级生产(NPP)。季节气候变率对NPP和gross primary production (GPP)无显著影响。然而,在厄尔Niño南方涛动(ENSO)期间,GPP和NPP出现了显著下降,尤其是在2015年。碳利用效率(CUE = NPP/GPP)也受到ENSO的影响,在厄尔尼诺Niño期间,CUE下降,特别是在10月和11月,无雨天数增加。潜热通量(LE)与感热通量(H)之差(LE-H)从8月到11月逐渐减小。这种差异与NPP高度相关。这说明当供水量不足时,气孔会关闭,从而减少光合作用和蒸腾作用,将更多的可用能量分配给感热通量而不是潜热通量。
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引用次数: 0
Prediction of Carbon Monoxide Concentration with Variation of Support Vector Regression Kernel Parameter Value 基于支持向量回归核参数值变化的一氧化碳浓度预测
IF 0.7 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2022-03-02 DOI: 10.5614/j.math.fund.sci.2022.54.1.3
Halawa Ernwati, Y. Bindar, A. Purqon, W. Srigutomo
Human and industrial activities produce air pollutants that can cause a decline in air quality. In urban areas, transportation activities are the main source of air pollution. One of the emitted air pollutants produced by transportation is carbon monoxide (CO). The understanding of CO concentration is crucial since its overabundance beyond a certain limit will have a negative impact on human health and the environment. In this study, the support vector regression (SVR) method was used to predict CO concentration. The purpose of this study was to predict the hourly CO concentration in the Ujung Berung district, Bandung City, West Java, Indonesia with optimal prediction accuracy. An experiment was carried out by modeling the CO concentration with varying kernel parameter values to obtain accurate prediction results. The suitability of the values between error (ɛ), a trade-off constant (C), and variation mismatch (γ) is vital to obtain optimal prediction results. The results showed that the best prediction accuracy value was 97.68% with kernel parameter values ɛ = 0.02, γ = 30, and C = 0.006. These results may lead to proper decision making on environmental issues and can improve air pollution control strategies.
人类和工业活动产生的空气污染物会导致空气质量下降。在城市地区,交通活动是空气污染的主要来源。交通运输产生的大气污染物之一是一氧化碳(CO)。对CO浓度的了解是至关重要的,因为CO浓度超过一定限度就会对人类健康和环境产生负面影响。本研究采用支持向量回归(SVR)方法对CO浓度进行预测。本研究的目的是预测每小时CO浓度在Ujung Berung地区,万隆市,西爪哇,印度尼西亚,以最佳的预测精度。为了获得准确的预测结果,对不同核参数值的CO浓度进行了模拟实验。误差(j)、权衡常数(C)和变异失配(γ)之间值的适宜性对于获得最佳预测结果至关重要。结果表明,当核参数值为ε = 0.02, γ = 30, C = 0.006时,最佳预测准确率为97.68%。这些结果可能会导致对环境问题的正确决策,并可以改善空气污染控制策略。
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引用次数: 0
Analytical Solution for Bending and Free Vibrations of an Orthotropic Nanoplate based on the New Modified Couple Stress Theory and the Third-order Plate Theory 基于新修正耦合应力理论和三阶板理论的正交各向异性纳米板弯曲和自由振动解析解
IF 0.7 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2022-02-28 DOI: 10.5614/j.math.fund.sci.2022.54.1.2
M. Barulina, D. Kondratov, Sofia Galkina, O. Markelova
In the present work, the equations of motion of a thin orthotropic nanoplate were obtained based on the new modified couple stress theory and the third-order shear deformation plate theory. The nanoplate was considered as a size-dependent orthotropic plate. The governing equations were derived using the dynamic version of Hamilton’s principle and natural boundary conditions were formulated. An analytical solution in the form of a double Fourier series was obtained for a simply supported rectangular nanoplate. The eigenvalue problem was set and solved. It was analytically shown that the displacements of the median surface points in the plane of the plate do not depend on the material length scale parameters in the same directions; these in-plane directional displacements depend on the material length scale parameter in the out-of-plane direction only. On the other hand, the out-of-plane directional displacement depends on the length scale parameter in the plane directions only. The cross-section rotation angles depend on all length scale parameters. It was shown that the size-dependent parameters only have a noticeable effect on the deformed state of the plate if their order is not less than the order (plate height)-1.
本文基于新修正的耦合应力理论和三阶剪切变形板理论,建立了正交各向异性纳米薄片的运动方程。将纳米板视为尺寸相关的正交各向异性板。利用Hamilton原理的动态版本推导了控制方程,并建立了自然边界条件。得到了简支矩形纳米板的双傅立叶级数形式的解析解。设置并求解了特征值问题。解析结果表明,在同一方向上,中面点在板材平面上的位移不依赖于材料长度尺度参数;这些面内方向位移仅取决于面外方向的材料长度尺度参数。另一方面,面外方向位移仅取决于平面方向上的长度尺度参数。截面旋转角度取决于所有长度尺度参数。结果表明,尺寸相关参数的阶数不小于阶数(板高)-1时,对板的变形状态有显著影响。
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引用次数: 3
Dielectric Meta-lattices with Tunable Reflectivity 具有可调反射率的介电元晶格
IF 0.7 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2022-02-28 DOI: 10.5614/j.math.fund.sci.2022.54.1.1
S. D. Isro, Soehianie Agoes, A. Iskandar
We report a study on the reflective performance of a dielectric meta-lattice formed by a one-dimensional periodic arrangement of silicon nanotubes. It was found that switching from transparent state to reflective state can be done by simply varying one optical parameter of the meta-lattice. The meta-lattice was shown to be capable of providing near-zero and near-unity reflectance at any desired wavelength, even in oblique incidence cases. The results are thus very promising for the development of future optical devices.
本文报道了一种由硅纳米管一维周期性排列形成的介电元晶格的反射性能研究。发现可以通过改变元晶格的一个光学参数来实现从透明状态到反射状态的切换。元晶格被证明能够提供近零和近单位的反射率,在任何所需的波长,甚至在斜入射的情况下。因此,该结果对未来光学器件的发展非常有希望。
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引用次数: 0
Ficus elastica Leaf Extract Effect Toward IL-10 and TNF-α as a Preeclampsia Model on Hypoxia-induced EA.hy926 弹性榕叶提取物对IL-10和TNF-α作为缺氧诱导的子痫前期模型的影响[j]
IF 0.7 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2022-01-18 DOI: 10.5614/j.math.fund.sci.2021.53.3.10
C. Ginting, I. Lister, Ermi Girsang, M. Mutia, Y. E. P. Lubis, A. Amalia, W. Widodo, D. Artie, R. Rizal, W. Widowati
Preeclampsia is a pregnancy complication characterized by proteinuria, hypertension, hypoxia as well an increased systemic inflammatory response. It affects 5 to 10% of all births and is a leading factor in fetal and maternal morbidity and death. Ficus elastica L. leaves are known to have natural compounds with anti-inflammatory and antioxidant properties. This research assessed the potential of F. elastica leaf extract (FEE) as anti-inflammatory agent in a hypoxic-induced human endothelial cell line (EA.hy926) as preeclampsia model. F. elastica leaves were extracted using 70% ethanol. Cytotoxic assay of the FEE in different concentrations (3.13 to 100 µg/ml) against EA.hy926 was done using MTS assay. The FEE’s anti-inflammatory activity was measured with ELISA for the TNF-α and IL-10 parameters. The FEE did not cause cytotoxicity to the EA.hy926 cells, with viability above 80% at the highest concentration. The FEE could decrease the pro-inflammatory TNF-α level and increase the IL-10 level as anti-inflammatory markers in the preeclampsia model at significance level p < 0.05. This study suggests that FEE is a safe alternative herbal medicine for preeclampsia treatment.
子痫前期是一种以蛋白尿、高血压、缺氧以及全身炎症反应增加为特征的妊娠并发症。它影响所有分娩的5%至10%,是胎儿和产妇发病率和死亡的主要因素。众所周知,弹性榕树的叶子含有抗炎和抗氧化的天然化合物。本研究评估了弹性枫叶提取物(FEE)在缺氧诱导的人内皮细胞系(EA.hy926)作为子痫前期模型中的抗炎作用。用70%乙醇提取松香叶。采用MTS法测定不同浓度(3.13 ~ 100µg/ml) FEE对EA.hy926的细胞毒性。采用ELISA法测定TNF-α和IL-10的抗炎活性。FEE对EA.hy926细胞无细胞毒性,最高浓度时细胞存活率在80%以上。在子痫前期模型中,FEE可降低促炎因子TNF-α水平,升高IL-10水平,差异均有统计学意义(p < 0.05)。这项研究表明,FEE是一种安全的替代草药治疗先兆子痫。
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引用次数: 1
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