Pub Date : 2020-12-31DOI: 10.5614/J.MATH.FUND.SCI.2020.52.3.7
O. Qasim, K. Abed, A. F. Qasim
In this paper, several parameters of the non-linear Hirota-Satsuma coupled KdV system were estimated using a hybrid between the Firefly Algorithm (FFA) and the Modified Adomian decomposition method (MADM). It turns out that optimal parameters can significantly improve the solutions when using a suitably selected fitness function for this problem. The results obtained show that the approximate solutions are highly compatible with the exact solutions and that the hybrid method FFA_MADM gives higher efficiency and accuracy compared to the classic MADM method.
{"title":"Optimal Parameters for Nonlinear Hirota-Satsuma Coupled KdV System by Using Hybrid Firefly Algorithm with Modified Adomian Decomposition","authors":"O. Qasim, K. Abed, A. F. Qasim","doi":"10.5614/J.MATH.FUND.SCI.2020.52.3.7","DOIUrl":"https://doi.org/10.5614/J.MATH.FUND.SCI.2020.52.3.7","url":null,"abstract":"In this paper, several parameters of the non-linear Hirota-Satsuma coupled KdV system were estimated using a hybrid between the Firefly Algorithm (FFA) and the Modified Adomian decomposition method (MADM). It turns out that optimal parameters can significantly improve the solutions when using a suitably selected fitness function for this problem. The results obtained show that the approximate solutions are highly compatible with the exact solutions and that the hybrid method FFA_MADM gives higher efficiency and accuracy compared to the classic MADM method.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"21 1","pages":"339-352"},"PeriodicalIF":0.7,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74210688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.5614/J.MATH.FUND.SCI.2020.52.3.1
F. Nawaz, B. Jan, F. Afridi, M. A. K. Yousufzai, F. Mehmood
This paper presents an analysis of cosmic ray intensity in Pakistan air space using spatial interpolation, comparing it with Chinese cosmic ray records from 1984 to 1993. The Exploratory Data Analytic (EDA) approach was applied to compare the cosmic ray fluctuations in both countries. The time series plot of the monthly cosmic rays showed relatively flatter counts in Pakistan than in China. The cosmic ray data for the years 1984 to 1993 fell within Solar Cycle 22, which lasted from 1986 to 1996, with its maximum phase in 1989 to 1991. The cosmic radiation varies between the atmospheric regions of Pakistan and China due to modulations in intensity that are accessible accordingly. It can be explained by purely astrophysical phenomena: (1) the source of emission of cosmic radiation may be different, (2) the rate at which emanation takes place depends on bursts of deep space dynamical objects from their sources that may be affected by solar wind and other solar radiations. Therefore, modulations in intensity are not only due to different geophysical locations. This study will help government organizations to predict and forecast cosmic rays values.
{"title":"Comparative Study of the Dynamics of Cosmic Rays for the Pakistan and China Atmospheric Regions","authors":"F. Nawaz, B. Jan, F. Afridi, M. A. K. Yousufzai, F. Mehmood","doi":"10.5614/J.MATH.FUND.SCI.2020.52.3.1","DOIUrl":"https://doi.org/10.5614/J.MATH.FUND.SCI.2020.52.3.1","url":null,"abstract":"This paper presents an analysis of cosmic ray intensity in Pakistan air space using spatial interpolation, comparing it with Chinese cosmic ray records from 1984 to 1993. The Exploratory Data Analytic (EDA) approach was applied to compare the cosmic ray fluctuations in both countries. The time series plot of the monthly cosmic rays showed relatively flatter counts in Pakistan than in China. The cosmic ray data for the years 1984 to 1993 fell within Solar Cycle 22, which lasted from 1986 to 1996, with its maximum phase in 1989 to 1991. The cosmic radiation varies between the atmospheric regions of Pakistan and China due to modulations in intensity that are accessible accordingly. It can be explained by purely astrophysical phenomena: (1) the source of emission of cosmic radiation may be different, (2) the rate at which emanation takes place depends on bursts of deep space dynamical objects from their sources that may be affected by solar wind and other solar radiations. Therefore, modulations in intensity are not only due to different geophysical locations. This study will help government organizations to predict and forecast cosmic rays values.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"87 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82074086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.5614/J.MATH.FUND.SCI.2020.52.3.4
S. Mungkasi
The susceptible-infected-recovered (SIR) model of the spread of dengue fever for the case of South Sulawesi is considered. Rangkuti’s variational iteration method (RVIM) is recalled. This paper makes four contributions. The first one is to provide a successive approximation method (SAM) for solving the considered model. The second one is to show that SAM and RVIM are identical. Thirdly, a modification of RVIM is proposed. Fourthly, it is shown that the modification leads to an improvement of the accuracy of the method. Both RVIM and the improved version are quite accurate for short time periods. However, the improved version is more accurate and is able to provide more realistic explicit solutions to the model.
{"title":"Improved Variational Iteration Solutions to the SIR Model of Dengue Fever Disease for the Case of South Sulawesi","authors":"S. Mungkasi","doi":"10.5614/J.MATH.FUND.SCI.2020.52.3.4","DOIUrl":"https://doi.org/10.5614/J.MATH.FUND.SCI.2020.52.3.4","url":null,"abstract":"The susceptible-infected-recovered (SIR) model of the spread of dengue fever for the case of South Sulawesi is considered. Rangkuti’s variational iteration method (RVIM) is recalled. This paper makes four contributions. The first one is to provide a successive approximation method (SAM) for solving the considered model. The second one is to show that SAM and RVIM are identical. Thirdly, a modification of RVIM is proposed. Fourthly, it is shown that the modification leads to an improvement of the accuracy of the method. Both RVIM and the improved version are quite accurate for short time periods. However, the improved version is more accurate and is able to provide more realistic explicit solutions to the model.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"109 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72935511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.5614/J.MATH.FUND.SCI.2020.52.3.2
M. Arba, S. N. Safitri, A. N. Hidayat, Arry Yanuar, M. Zubair, A. Djalil, D. H. Tjahjono
The Janus tyrosine kinases (JAKs) have shown great promise as therapeutic protein targets in the treatment of cancer and inflammation diseases. This study used pharmacophore modeling to identify potential inhibitors of Janus kinase 3 (JAK3). A pharmacophore model was developed based on a known JAK3 inhibitor (1NX) and was employed to search for potential JAK3 inhibitors against Indonesian herbal compounds. Among 28 hit molecules that were identified and subjected to a molecular docking protocol against JAK3, the three compounds that had the highest affinities toward JAK3 were camelliaside B, 3-O-galloylepicatechin-(4beta-6)-epicatechin-3-O-gallate, and mesuaferrone B. These were then each subjected to a 50-ns molecular dynamics (MD) simulation. Analysis of RMSD and RMSF values indicated that the three compounds reached stability during the MD simulation. Interestingly, all three compounds had lower binding energies than 1NX against JAK3, as predicted by the MM-PBSA binding energy calculation.
Janus酪氨酸激酶(JAKs)作为治疗性蛋白靶点在癌症和炎症疾病的治疗中显示出巨大的前景。本研究使用药效团模型来鉴定Janus kinase 3 (JAK3)的潜在抑制剂。以已知的JAK3抑制剂(1NX)为基础建立药效团模型，用于寻找潜在的JAK3抑制剂。在鉴定的28个命中分子中，对JAK3进行了分子对接，对JAK3亲和力最高的3个化合物是茶花苷B、3- o -没食子表儿茶素-3- o -没食子酸酯和甲亚铁酮B。这些化合物分别进行了50-ns的分子动力学(MD)模拟。RMSD和RMSF值的分析表明，这三种化合物在MD模拟过程中达到了稳定。有趣的是，这三种化合物对JAK3的结合能都比1NX低，这与MM-PBSA结合能计算的结果一致。
{"title":"Molecular modeling on the identification of potential Janus Kinase 3 (JAK3) inhibitor based on the Indonesian Medicinal Plant Database","authors":"M. Arba, S. N. Safitri, A. N. Hidayat, Arry Yanuar, M. Zubair, A. Djalil, D. H. Tjahjono","doi":"10.5614/J.MATH.FUND.SCI.2020.52.3.2","DOIUrl":"https://doi.org/10.5614/J.MATH.FUND.SCI.2020.52.3.2","url":null,"abstract":"The Janus tyrosine kinases (JAKs) have shown great promise as therapeutic protein targets in the treatment of cancer and inflammation diseases. This study used pharmacophore modeling to identify potential inhibitors of Janus kinase 3 (JAK3). A pharmacophore model was developed based on a known JAK3 inhibitor (1NX) and was employed to search for potential JAK3 inhibitors against Indonesian herbal compounds. Among 28 hit molecules that were identified and subjected to a molecular docking protocol against JAK3, the three compounds that had the highest affinities toward JAK3 were camelliaside B, 3-O-galloylepicatechin-(4beta-6)-epicatechin-3-O-gallate, and mesuaferrone B. These were then each subjected to a 50-ns molecular dynamics (MD) simulation. Analysis of RMSD and RMSF values indicated that the three compounds reached stability during the MD simulation. Interestingly, all three compounds had lower binding energies than 1NX against JAK3, as predicted by the MM-PBSA binding energy calculation.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"26 1","pages":"276-285"},"PeriodicalIF":0.7,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85853514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.5614/J.MATH.FUND.SCI.2020.52.3.3
Nanan Nur’aeny, D. A. Gurnida, O. Suwarsa, I. Sufiawati
One of the most common oral ulcerations is recurrent aphthous stomatitis (RAS), affecting approximately 20% of the general population worldwide. The etiology of RAS is still unclear but it is considered to be multifactorial, including imbalanced nutrition intake and allergic conditions such as atopy. The purpose of this study was to investigate the differences and correlation between the serum level of IL-6, reactive oxygen species (ROS), and cortisol in RAS patients. Our study was cross-sectional and used a consecutive sampling method. There were significant differences of IL-6 and ROS levels in all groups (p = 0.000, p = 0.049 respectively) and a significant correlation between cortisol and ROS in the RAS group without atopy (r = -0.985, p = 0.015). Serum IL-6 and ROS measurement may be used for detecting RAS caused by malnutrition or atopy but not cortisol for patients without psychological stress detected. This is consistent with the results of a very strong correlation with a negative value between cortisol and ROS in RAS without atopy.
最常见的口腔溃疡之一是复发性口疮性口炎(RAS)，影响全世界约20%的总人口。RAS的病因尚不清楚，但被认为是多因素的，包括营养摄入不平衡和过敏性疾病，如特应性反应。本研究旨在探讨RAS患者血清IL-6、活性氧(reactive oxygen species, ROS)、皮质醇水平的差异及相关性。我们的研究是横断面的，采用连续抽样的方法。各组IL-6、ROS水平差异均有统计学意义(p = 0.000, p = 0.049)， RAS无特应性组皮质醇与ROS水平相关性显著(r = -0.985, p = 0.015)。血清IL-6和ROS测定可用于检测营养不良或特应性引起的RAS，但对未检测到心理应激的患者不能检测皮质醇。这与没有特应性的RAS中皮质醇和ROS呈负相关的结果是一致的。
{"title":"Serum Level of IL-6, Reactive Oxygen Species and Cortisol in Patients with Recurrent Aphthous Stomatitis related Imbalance Nutrition Intake and Atopy","authors":"Nanan Nur’aeny, D. A. Gurnida, O. Suwarsa, I. Sufiawati","doi":"10.5614/J.MATH.FUND.SCI.2020.52.3.3","DOIUrl":"https://doi.org/10.5614/J.MATH.FUND.SCI.2020.52.3.3","url":null,"abstract":"One of the most common oral ulcerations is recurrent aphthous stomatitis (RAS), affecting approximately 20% of the general population worldwide. The etiology of RAS is still unclear but it is considered to be multifactorial, including imbalanced nutrition intake and allergic conditions such as atopy. The purpose of this study was to investigate the differences and correlation between the serum level of IL-6, reactive oxygen species (ROS), and cortisol in RAS patients. Our study was cross-sectional and used a consecutive sampling method. There were significant differences of IL-6 and ROS levels in all groups (p = 0.000, p = 0.049 respectively) and a significant correlation between cortisol and ROS in the RAS group without atopy (r = -0.985, p = 0.015). Serum IL-6 and ROS measurement may be used for detecting RAS caused by malnutrition or atopy but not cortisol for patients without psychological stress detected. This is consistent with the results of a very strong correlation with a negative value between cortisol and ROS in RAS without atopy.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78842330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-08DOI: 10.5614/j.math.fund.sci.2020.52.2.7
Alviyanda Alviyanda, G. Junursyah, P. Sumintadireja
Biak Island is thought to have originated from the Australian Continental passive margin in the Mesozoic. This passive margin underwent tectonic collision to form the bedrock of Biak Island during the Paleogene. East Biak is covered by limestone, which is an obstacle to knowing the deeper stratigraphy. This study’s aim was to identify the subsurface geology of the East Biak area based on rock resistivity values. Magnetotelluric (MT) surveying is a passive geophysical method that is able to interpret subsurface geology based on rock resistivity values at depths of up to 5 to 10 km. The MT measurements in East Biak used 25 measurement points. Cross-sectional variations in rock resistivity values generated from the MT measurements were used to identify rock types in the East Biak subsurface. Five rock units were identified. The East Biak stratigraphy model is dominated by carbonates, comprising two sequences, i.e. an Early Neogene sequence with a thickness of 1,000 to 3,000 m and a Late Neogene to Quaternary sequence with a thickness of 180 to 2,450 m. The unconformity between these two sequences is due to tectonic activity, which separated Supiori and Biak Island.
{"title":"Stratigraphic Model of East Biak Based on Magnetotelluric Data","authors":"Alviyanda Alviyanda, G. Junursyah, P. Sumintadireja","doi":"10.5614/j.math.fund.sci.2020.52.2.7","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2020.52.2.7","url":null,"abstract":"Biak Island is thought to have originated from the Australian Continental passive margin in the Mesozoic. This passive margin underwent tectonic collision to form the bedrock of Biak Island during the Paleogene. East Biak is covered by limestone, which is an obstacle to knowing the deeper stratigraphy. This study’s aim was to identify the subsurface geology of the East Biak area based on rock resistivity values. Magnetotelluric (MT) surveying is a passive geophysical method that is able to interpret subsurface geology based on rock resistivity values at depths of up to 5 to 10 km. The MT measurements in East Biak used 25 measurement points. Cross-sectional variations in rock resistivity values generated from the MT measurements were used to identify rock types in the East Biak subsurface. Five rock units were identified. The East Biak stratigraphy model is dominated by carbonates, comprising two sequences, i.e. an Early Neogene sequence with a thickness of 1,000 to 3,000 m and a Late Neogene to Quaternary sequence with a thickness of 180 to 2,450 m. The unconformity between these two sequences is due to tectonic activity, which separated Supiori and Biak Island.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2020-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79427401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-08DOI: 10.5614/j.math.fund.sci.2020.52.2.8
Sabarinsyah Sabarinsyah, H. Garminia, P. Astuti
This paper introduces continuous-like linear operators on bilinear spaces as a generalization of continuous linear operators on Hilbert spaces. It is well known that the existence of the adjoint of a linear operator on a Hilbert space is equivalent to the operator being continuous. In this paper , this result is extended to the class of linear operators on bilinear spaces. It is shown that the existence of the adjoint of a linear operator on a bilinear space is guaranteed if and only if the operator is continuous-like.
{"title":"Continuous-Like Linear Operators on Bilinear Spaces","authors":"Sabarinsyah Sabarinsyah, H. Garminia, P. Astuti","doi":"10.5614/j.math.fund.sci.2020.52.2.8","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2020.52.2.8","url":null,"abstract":"This paper introduces continuous-like linear operators on bilinear spaces as a generalization of continuous linear operators on Hilbert spaces. It is well known that the existence of the adjoint of a linear operator on a Hilbert space is equivalent to the operator being continuous. In this paper , this result is extended to the class of linear operators on bilinear spaces. It is shown that the existence of the adjoint of a linear operator on a bilinear space is guaranteed if and only if the operator is continuous-like.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"51 1","pages":"250-258"},"PeriodicalIF":0.7,"publicationDate":"2020-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86147459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-06DOI: 10.5614/j.math.fund.sci.2020.52.2.6
I. Kambali, Rajiman Rajiman, Parwanto Parwanto, M. Marlina, K. Kardinah, Nur Huda, Ferdi D. Listiawadi, Herta Astarina, Ratu R. Ismuha, Heranudin Heranudin, H. Suryanto
Due to the declining number of available nuclear reactors capable of Tc-99m production and tight regulations related to uranium enrichment, cyclotron-based Tc-99m production has recently been suggested as a new method to help ease Tc-99m supply shortages. In this investigation, a solid natural MoO 3 target was irradiated using 11-MeV proton beams at variable proton doses. The proton doses were varied by varying the irradiation time while keeping the proton beam current constant at 20 µA. At the end of the bombardment, the post-irradiated solid MoO 3 targets were analyzed for their radioactive contents using a portable gamma-ray spectroscopy system. The analysis was also performed for the post-irradiated targets after dissolving the solid MoO 3 in a 6M NaOH solution. The experimental results indicated that as much as 75.71% of Tc-99m radioactivity was directly generated via a 100 Mo(p,2n) 99m Tc nuclear reaction, while the rest of the Tc-99m radioactivity was a result of a 98 Mo(n,γ) 99 Mo→ 99m Tc nuclear reaction. Apart from Tc-99m and Mo-99 radionuclides, some other radionuclides such as N-13, Tc-96, and Nb-96 were also recorded following temporal observation of the NaOH-dissolved MoO 3 . These experimental results open up the possibility of direct production of Tc-99m using a proton-accelerating cyclotron.
{"title":"Spectral Analysis of Proton-Irradiated Natural MoO3 Relevant for Technetium-99m Radionuclide Production","authors":"I. Kambali, Rajiman Rajiman, Parwanto Parwanto, M. Marlina, K. Kardinah, Nur Huda, Ferdi D. Listiawadi, Herta Astarina, Ratu R. Ismuha, Heranudin Heranudin, H. Suryanto","doi":"10.5614/j.math.fund.sci.2020.52.2.6","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2020.52.2.6","url":null,"abstract":"Due to the declining number of available nuclear reactors capable of Tc-99m production and tight regulations related to uranium enrichment, cyclotron-based Tc-99m production has recently been suggested as a new method to help ease Tc-99m supply shortages. In this investigation, a solid natural MoO 3 target was irradiated using 11-MeV proton beams at variable proton doses. The proton doses were varied by varying the irradiation time while keeping the proton beam current constant at 20 µA. At the end of the bombardment, the post-irradiated solid MoO 3 targets were analyzed for their radioactive contents using a portable gamma-ray spectroscopy system. The analysis was also performed for the post-irradiated targets after dissolving the solid MoO 3 in a 6M NaOH solution. The experimental results indicated that as much as 75.71% of Tc-99m radioactivity was directly generated via a 100 Mo(p,2n) 99m Tc nuclear reaction, while the rest of the Tc-99m radioactivity was a result of a 98 Mo(n,γ) 99 Mo→ 99m Tc nuclear reaction. Apart from Tc-99m and Mo-99 radionuclides, some other radionuclides such as N-13, Tc-96, and Nb-96 were also recorded following temporal observation of the NaOH-dissolved MoO 3 . These experimental results open up the possibility of direct production of Tc-99m using a proton-accelerating cyclotron.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"6 1","pages":"222-231"},"PeriodicalIF":0.7,"publicationDate":"2020-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90042745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-06DOI: 10.5614/j.math.fund.sci.2020.52.2.2
Hamza Abd El-Qader, A. T. A. Ghani, I. Qaralleh
The current study provides a new class of ξ(as)-QSO defined on 2D simplex and classifies it into 18 non-conjugate (isomorphic) classes. This classification is based on their conjugacy and the remuneration of coordinates. The current study also examines the limiting points associated with the behavior of trajectories for four classes defined on 2D simplex.
{"title":"Classification and Dynamics of Class of ξ(as)-QSO","authors":"Hamza Abd El-Qader, A. T. A. Ghani, I. Qaralleh","doi":"10.5614/j.math.fund.sci.2020.52.2.2","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2020.52.2.2","url":null,"abstract":"The current study provides a new class of ξ(as)-QSO defined on 2D simplex and classifies it into 18 non-conjugate (isomorphic) classes. This classification is based on their conjugacy and the remuneration of coordinates. The current study also examines the limiting points associated with the behavior of trajectories for four classes defined on 2D simplex.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"12 1","pages":"143-173"},"PeriodicalIF":0.7,"publicationDate":"2020-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81207195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-06DOI: 10.5614/j.math.fund.sci.2020.52.2.3
B. Purwanto, S. Siswandono, Suko Hardjono, Dian Triwidiandany
Urea derivatives are extensively used in the pharmaceutical industry. However, the unsatisfactory level of their membrane penetration requires further modification of the structures with stronger lipophillic properties. Phenylurea has a phenyl group that enables easier membrane penetration as a result of stronger pharmacological activity. Activity prediction was conducted by docking experiments and molecular dynamics, performed with Molegro Virtual Docker 5.5 using checkpoint kinase 1 (CHK1) enzyme with ID PDB: 2YWP. ADMET prediction was applied to collect data using the pkCSM tool. N -(phenyl carbamyol)benzamide compounds, modified by the Schotten Baumann method, were synthesized from benzoil chloride reacting with N -phenylurea. For evaluating anticancer activity, the MTT assay method on HeLa cells was used. Derived from the docking experiments, the compound rerank score of the N -(phenylcarbamoyl)benzamide was 72.0603 kcal/mol, lower than that of hydroxyurea, -32.1514 kcal/mol, causing better inhibitory activities against HeLA cell lines due to higher cytotoxic effects. ADMET Predictor was employed, indicating satisfactory compound distribution with a low, favorable metabolism, possessing good excretion and non-toxicity. The synthesized compound was 82% N- (phenyl carbamoyl)benzamide with 0.8 mM IC 80 , higher than that of hydroxyurea, 4.3 mM. In conclusion, successfully synthesized N- (phenylcarbamoyl)benzamide was proved to have higher cytotoxic effects. The satisfactory values of these compounds indicate that they are promising anticancer drug candidates.
{"title":"Rational Design, Synthesis and Cytotoxic Activity of N-(Phenylcarbamoyl)Benzamide on HeLa Cell Lines","authors":"B. Purwanto, S. Siswandono, Suko Hardjono, Dian Triwidiandany","doi":"10.5614/j.math.fund.sci.2020.52.2.3","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2020.52.2.3","url":null,"abstract":"Urea derivatives are extensively used in the pharmaceutical industry. However, the unsatisfactory level of their membrane penetration requires further modification of the structures with stronger lipophillic properties. Phenylurea has a phenyl group that enables easier membrane penetration as a result of stronger pharmacological activity. Activity prediction was conducted by docking experiments and molecular dynamics, performed with Molegro Virtual Docker 5.5 using checkpoint kinase 1 (CHK1) enzyme with ID PDB: 2YWP. ADMET prediction was applied to collect data using the pkCSM tool. N -(phenyl carbamyol)benzamide compounds, modified by the Schotten Baumann method, were synthesized from benzoil chloride reacting with N -phenylurea. For evaluating anticancer activity, the MTT assay method on HeLa cells was used. Derived from the docking experiments, the compound rerank score of the N -(phenylcarbamoyl)benzamide was 72.0603 kcal/mol, lower than that of hydroxyurea, -32.1514 kcal/mol, causing better inhibitory activities against HeLA cell lines due to higher cytotoxic effects. ADMET Predictor was employed, indicating satisfactory compound distribution with a low, favorable metabolism, possessing good excretion and non-toxicity. The synthesized compound was 82% N- (phenyl carbamoyl)benzamide with 0.8 mM IC 80 , higher than that of hydroxyurea, 4.3 mM. In conclusion, successfully synthesized N- (phenylcarbamoyl)benzamide was proved to have higher cytotoxic effects. The satisfactory values of these compounds indicate that they are promising anticancer drug candidates.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"27 1","pages":"174-188"},"PeriodicalIF":0.7,"publicationDate":"2020-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81760949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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