Pub Date : 2020-04-28DOI: 10.5614/j.math.fund.sci.2020.52.1.6
W. Lestari, Wulan Cahya Inayah, F. Rahmawati, Larasati Larasati, A. Purwanto
This research was aimed at synthesizing metal-organic frameworks (MOFs) based on zinc(II) and a benzene-1,3,5-tricarboxylate (BTC) linker in combination with graphite as anode material in lithium-ion batteries. The MOFs were prepared using sonochemical and solvothermal methods, which led to different materials: [Zn 3 (BTC) 2 ·12H 2 O] (MOF 1) and [Zn(BTC)·H 2 O·3DMF] (MOF 2). The produced materials were characterized by powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric/differential thermal analysis (TG/DTA), and a battery analyzer. Refinement of the XRD data was performed using the Rietica and Le Bail method. Sharp and intense peaks indicated that the materials had a high degree of crystallinity. The morphology of the materials as analyzed by SEM was cubic, with an average crystal size of 8.377 ± 4.276 µm for MOF 1 and a larger size of 16.351 ± 3.683 µm for MOF 2. MOF 1 was thermally stable up to 378.7 °C while MOF 2 remained stable up to 341.8 °C, as demonstrated by thermogravimetric analysis. The employment of the synthesized materials as anode in a lithium ion battery was proved to yield higher specific capacity and cycle stability compared to those using a graphite anode. The lithium-ion battery with 5 wt% MOF 1 exhibited the highest performance with an efficiency of 97.28%, and charge and discharge specific capacities of 123.792 and 120.421 mAh/g, respectively.
{"title":"Metal-Organic Frameworks Based on Zinc(II) and Benzene-1,3,5-Tricarboxylate Modified Graphite: Fabrication and Application as an Anode Material in Lithium-Ion Batteries","authors":"W. Lestari, Wulan Cahya Inayah, F. Rahmawati, Larasati Larasati, A. Purwanto","doi":"10.5614/j.math.fund.sci.2020.52.1.6","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2020.52.1.6","url":null,"abstract":"This research was aimed at synthesizing metal-organic frameworks (MOFs) based on zinc(II) and a benzene-1,3,5-tricarboxylate (BTC) linker in combination with graphite as anode material in lithium-ion batteries. The MOFs were prepared using sonochemical and solvothermal methods, which led to different materials: [Zn 3 (BTC) 2 ·12H 2 O] (MOF 1) and [Zn(BTC)·H 2 O·3DMF] (MOF 2). The produced materials were characterized by powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric/differential thermal analysis (TG/DTA), and a battery analyzer. Refinement of the XRD data was performed using the Rietica and Le Bail method. Sharp and intense peaks indicated that the materials had a high degree of crystallinity. The morphology of the materials as analyzed by SEM was cubic, with an average crystal size of 8.377 ± 4.276 µm for MOF 1 and a larger size of 16.351 ± 3.683 µm for MOF 2. MOF 1 was thermally stable up to 378.7 °C while MOF 2 remained stable up to 341.8 °C, as demonstrated by thermogravimetric analysis. The employment of the synthesized materials as anode in a lithium ion battery was proved to yield higher specific capacity and cycle stability compared to those using a graphite anode. The lithium-ion battery with 5 wt% MOF 1 exhibited the highest performance with an efficiency of 97.28%, and charge and discharge specific capacities of 123.792 and 120.421 mAh/g, respectively.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"17 1","pages":"81-97"},"PeriodicalIF":0.7,"publicationDate":"2020-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82174447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-10DOI: 10.1101/2020.04.08.20057638
Saydaliev Hayot Berk, S. Kadyrov
It has been three months since the novel coronavirus (COVID-19) pandemic outbreak. Many research studies were carried to understand its epidemiological characteristics in the early phase of the disease outbreak. The current study is yet another contribution to better understand the disease properties by parameter estimation of mathematical SIR epidemic modeling. The authors use Johns Hopkins University dataset to estimate the basic reproduction number of COVID-19 for representative countries (Japan, Germany, Italy, France, and Netherlands) selected using cluster analysis. As a by-product, the authors estimate transmission, recovery, and death rates for each selected country and carry statistical tests to see if there are any significant differences.
{"title":"Purely data-driven exploration of COVID-19 pandemic after three months of the outbreak","authors":"Saydaliev Hayot Berk, S. Kadyrov","doi":"10.1101/2020.04.08.20057638","DOIUrl":"https://doi.org/10.1101/2020.04.08.20057638","url":null,"abstract":"It has been three months since the novel coronavirus (COVID-19) pandemic outbreak. Many research studies were carried to understand its epidemiological characteristics in the early phase of the disease outbreak. The current study is yet another contribution to better understand the disease properties by parameter estimation of mathematical SIR epidemic modeling. The authors use Johns Hopkins University dataset to estimate the basic reproduction number of COVID-19 for representative countries (Japan, Germany, Italy, France, and Netherlands) selected using cluster analysis. As a by-product, the authors estimate transmission, recovery, and death rates for each selected country and carry statistical tests to see if there are any significant differences.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"70 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86995923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.5614/j.math.fund.sci.2019.51.3.4
U. S. Rajput, Mohammad Shareef
MHD free convective flow with oscillations of an infinite non-conducting vertical flat surface through a porous medium with Hall current in a rotating system was studied. The governing equations of the model were converted into dimensionless form. Analytical solutions for velocity and temperature were obtained with the help of the Laplace transform method. Graphs and tables are used in this paper to show the influence of various parameters on temperature, skin friction and velocity. It was observed that changes in plate oscillation, porous medium, radiation and Hall current have significant effects on fluid motion. Further, the skin friction near the surface is increased by the radiation parameter. The results obtained have large implications in the engineering and science fields.
{"title":"MHD Free Convective Flow along Vertical Oscillatory Plate with Radiative Heat Transfer in the Presence of Hall Current and Heat Source","authors":"U. S. Rajput, Mohammad Shareef","doi":"10.5614/j.math.fund.sci.2019.51.3.4","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2019.51.3.4","url":null,"abstract":"MHD free convective flow with oscillations of an infinite non-conducting vertical flat surface through a porous medium with Hall current in a rotating system was studied. The governing equations of the model were converted into dimensionless form. Analytical solutions for velocity and temperature were obtained with the help of the Laplace transform method. Graphs and tables are used in this paper to show the influence of various parameters on temperature, skin friction and velocity. It was observed that changes in plate oscillation, porous medium, radiation and Hall current have significant effects on fluid motion. Further, the skin friction near the surface is increased by the radiation parameter. The results obtained have large implications in the engineering and science fields.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"4 1","pages":"252-264"},"PeriodicalIF":0.7,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87423927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.5614/j.math.fund.sci.2019.51.3.1
W. Widowati, D. Jasaputra, Philips Onggowidjaja, S. Sumitro, M. A. Widodo, Ervi Afifah, Dwi Davidson Rihibiha, R. Rizal, A. Amalia, H. Kusuma, Harry Murti, I. Bachtiar
Breast cancer (BC) is the most prevalent type of cancer among women and one of the major causes of cancer mortality in women. Metastasis in breast cancer (BC) occurs due to immunosurveillance deficiency, including impairment of natural killer (NK) cell maturation. Conditioned medium (CM) from human Wharton’s jelly mesenchymal stem cells (hWJMSC-CM) is known to possess anticancer activity. The CM of co-culture of human recombinant IL-2 treated NK cells and hWJMSCs is expected to boost anticancer activity toward BC cells which can be analyzed from the effect of CM towards secretion of effector molecules and expression of BC cell apoptosis-related genes, and cytotoxic granules in human recombinant IL-2 treated NK (IL-2 NK) and hWJMSCs (IL-2 hWJMSCs). TNF-α, IFN-γ, perforin, granzyme were measured by ELISA, while the inhibition of cell proliferation was measured by MTS assay and BC cell apoptosis by flow cytometry and apoptotic gene expression by RTPCR. CM from co-cultured hWJMSCs and IL-2 NK cells inhibited NK and BC cell proliferation, increased expression of Bax and p53 and decreased the number of Bcl-2 in BC cells. In conclusion, CM of co-culture IL-2 treated NK cells and hWJMSCs induce apoptosis in BC cells as indicated by increased Bax and p53 expression and decreased Bcl-2 expression.
{"title":"Effects of Conditioned Medium of Co-Culture IL-2 Induced NK Cells and Human Wharton’s Jelly Mesenchymal Stem Cells (hWJMSCs) on Apoptotic Gene Expression in a Breast Cancer Cell Line (MCF-7)","authors":"W. Widowati, D. Jasaputra, Philips Onggowidjaja, S. Sumitro, M. A. Widodo, Ervi Afifah, Dwi Davidson Rihibiha, R. Rizal, A. Amalia, H. Kusuma, Harry Murti, I. Bachtiar","doi":"10.5614/j.math.fund.sci.2019.51.3.1","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2019.51.3.1","url":null,"abstract":"Breast cancer (BC) is the most prevalent type of cancer among women and one of the major causes of cancer mortality in women. Metastasis in breast cancer (BC) occurs due to immunosurveillance deficiency, including impairment of natural killer (NK) cell maturation. Conditioned medium (CM) from human Wharton’s jelly mesenchymal stem cells (hWJMSC-CM) is known to possess anticancer activity. The CM of co-culture of human recombinant IL-2 treated NK cells and hWJMSCs is expected to boost anticancer activity toward BC cells which can be analyzed from the effect of CM towards secretion of effector molecules and expression of BC cell apoptosis-related genes, and cytotoxic granules in human recombinant IL-2 treated NK (IL-2 NK) and hWJMSCs (IL-2 hWJMSCs). TNF-α, IFN-γ, perforin, granzyme were measured by ELISA, while the inhibition of cell proliferation was measured by MTS assay and BC cell apoptosis by flow cytometry and apoptotic gene expression by RTPCR. CM from co-cultured hWJMSCs and IL-2 NK cells inhibited NK and BC cell proliferation, increased expression of Bax and p53 and decreased the number of Bcl-2 in BC cells. In conclusion, CM of co-culture IL-2 treated NK cells and hWJMSCs induce apoptosis in BC cells as indicated by increased Bax and p53 expression and decreased Bcl-2 expression.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"580 1","pages":"205-224"},"PeriodicalIF":0.7,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77368736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.5614/j.math.fund.sci.2019.51.3.6
Adarsh Anand, Subhrata Das, Mohini Agarwal, V. Yadavalli
Many reliability growth models related to the concept of multi-upgrading have recently been proposed. This concept has helped software developers to develop a competitive edge over competitors by regularly introducing their software upgrades in the market at the optimal moment. The software reliability literature offers many different release-time policies, both under crisp and fuzzy environment. This paper presents a generic model of a multi-upgraded software system. The optimal scheduling policy for software under a fuzzy environment was determined. The proposed model was examined on a real-life failure data set of four software releases. The results obtained are encouraging.
{"title":"Optimal Scheduling Policy for a Multi-upgraded Software System under Fuzzy Environment","authors":"Adarsh Anand, Subhrata Das, Mohini Agarwal, V. Yadavalli","doi":"10.5614/j.math.fund.sci.2019.51.3.6","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2019.51.3.6","url":null,"abstract":"Many reliability growth models related to the concept of multi-upgrading have recently been proposed. This concept has helped software developers to develop a competitive edge over competitors by regularly introducing their software upgrades in the market at the optimal moment. The software reliability literature offers many different release-time policies, both under crisp and fuzzy environment. This paper presents a generic model of a multi-upgraded software system. The optimal scheduling policy for software under a fuzzy environment was determined. The proposed model was examined on a real-life failure data set of four software releases. The results obtained are encouraging.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"9 1","pages":"278-293"},"PeriodicalIF":0.7,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85778357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.5614/j.math.fund.sci.2019.51.3.7
Regina Giovanni, U. A. Wibowo, H. Judawisastra, A. Barlian
Skin tissue engineering is a developing technology to heal severe wounds. Combining polyvinyl alcohol (PVA) and silk fibroin (SF) nanofibers is a promising method of developing a skin scaffold because the resulting structure mimics collagen fibers. The aim of this research was to study the growth of human dermal fibroblasts (HDF) on a polyvinyl alcohol-silk fibroin (PVA-SF) nanofiber scaffold that was produced by electrospinning. Morphological characterization and chemical analysis of the scaffold were performed by scanning electron microscopy (SEM), Fourier transform infrared spectrophotometry (FTIR), and contact angle measurement. The biocompatibility of the scaffold was tested by MTT cytotoxicity assay, SEM analysis, adherence ratio calculation, and analysis of the HDF growth curve for 9 days. The FTIR results confirmed the presence of SF and PVA. The average fiber diameter and pore size of the PVA scaffold were greater than those of the PVA-SF scaffold. Both scaffolds had hydrophilic properties and were not cytotoxic. Thus, HDF can attach and grow on both types of scaffold better than HDF seeded on a polystyrene plate. In conclusion, the addition of SF to the PVA nanofibers caused bead formation, which affected the substrate topography, decreased hydrophilicity and also decreased the fiber diameter and pore size in the nanofiber scaffold compared to the PVA nanofiber scaffold without SF addition. SF addition increases cell attachment to the nanofiber scaffold and has potential to facilitate HDF cell growth.
{"title":"Growth of Human Dermal Fibroblasts on Polyvinyl Alcohol-Silk Fibroin Nanofiber Scaffold","authors":"Regina Giovanni, U. A. Wibowo, H. Judawisastra, A. Barlian","doi":"10.5614/j.math.fund.sci.2019.51.3.7","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2019.51.3.7","url":null,"abstract":"Skin tissue engineering is a developing technology to heal severe wounds. Combining polyvinyl alcohol (PVA) and silk fibroin (SF) nanofibers is a promising method of developing a skin scaffold because the resulting structure mimics collagen fibers. The aim of this research was to study the growth of human dermal fibroblasts (HDF) on a polyvinyl alcohol-silk fibroin (PVA-SF) nanofiber scaffold that was produced by electrospinning. Morphological characterization and chemical analysis of the scaffold were performed by scanning electron microscopy (SEM), Fourier transform infrared spectrophotometry (FTIR), and contact angle measurement. The biocompatibility of the scaffold was tested by MTT cytotoxicity assay, SEM analysis, adherence ratio calculation, and analysis of the HDF growth curve for 9 days. The FTIR results confirmed the presence of SF and PVA. The average fiber diameter and pore size of the PVA scaffold were greater than those of the PVA-SF scaffold. Both scaffolds had hydrophilic properties and were not cytotoxic. Thus, HDF can attach and grow on both types of scaffold better than HDF seeded on a polystyrene plate. In conclusion, the addition of SF to the PVA nanofibers caused bead formation, which affected the substrate topography, decreased hydrophilicity and also decreased the fiber diameter and pore size in the nanofiber scaffold compared to the PVA nanofiber scaffold without SF addition. SF addition increases cell attachment to the nanofiber scaffold and has potential to facilitate HDF cell growth.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"24 1","pages":"294-308"},"PeriodicalIF":0.7,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73679830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.5614/j.math.fund.sci.2019.51.3.5
H. Suryawan
A class of stochastic processes with memory within the framework of the Hida calculus was studied. It was proved that the Donsker delta functionals of the processes are Hida distributions. Furthermore, the probability density function of the processes and the chaos decomposition of the Donsker delta functional were derived. As an application, the existence of the renormalized local times in an arbitrary dimension of the Riemann-Liouville fractional Brownian motion as a white noise generalized function was proved.
{"title":"Donsker’s Delta Functional of Stochastic Processes with Memory","authors":"H. Suryawan","doi":"10.5614/j.math.fund.sci.2019.51.3.5","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2019.51.3.5","url":null,"abstract":"A class of stochastic processes with memory within the framework of the Hida calculus was studied. It was proved that the Donsker delta functionals of the processes are Hida distributions. Furthermore, the probability density function of the processes and the chaos decomposition of the Donsker delta functional were derived. As an application, the existence of the renormalized local times in an arbitrary dimension of the Riemann-Liouville fractional Brownian motion as a white noise generalized function was proved.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"51 1","pages":"265-277"},"PeriodicalIF":0.7,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86349493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.5614/j.math.fund.sci.2019.51.3.3
A. Aprilia, H. Malasan, G. E. Ramadhania, A. T. P. Jatmiko, M. Irfan, D. G. Ramadhan, A. N. Istiqomah, E. I. Akbar
Hα line variations of 8 B-emission (Be) stars are presented. Stars that are listed in the Bright Star Catalogue were observed in 2009 at the Bosscha Observatory, Lembang, Indonesia. It was found that 4 stars showed phase changing from Be double-peaked to Be single-peaked emission line profiles, 1 showed single-peaked to double-peaked profiles, 1 showed double-peaked to B-normal, while two other stars did not show phase changing. The stars also showed variations in the V/R and E/C values, which represent the strength of the emission lines. The phase changes were detected from a comparison of the observed data to the current data in the BeSS database.
{"title":"B-emission Stars in Southern Sky Observed in Bosscha Observatory: Spectroscopic Study of Hα Spectral Line Variability","authors":"A. Aprilia, H. Malasan, G. E. Ramadhania, A. T. P. Jatmiko, M. Irfan, D. G. Ramadhan, A. N. Istiqomah, E. I. Akbar","doi":"10.5614/j.math.fund.sci.2019.51.3.3","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2019.51.3.3","url":null,"abstract":"Hα line variations of 8 B-emission (Be) stars are presented. Stars that are listed in the Bright Star Catalogue were observed in 2009 at the Bosscha Observatory, Lembang, Indonesia. It was found that 4 stars showed phase changing from Be double-peaked to Be single-peaked emission line profiles, 1 showed single-peaked to double-peaked profiles, 1 showed double-peaked to B-normal, while two other stars did not show phase changing. The stars also showed variations in the V/R and E/C values, which represent the strength of the emission lines. The phase changes were detected from a comparison of the observed data to the current data in the BeSS database.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"70 1","pages":"243-251"},"PeriodicalIF":0.7,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82714843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.5614/j.math.fund.sci.2019.51.3.2
Meiridha Mutiara Andania, F. Ismed, M. Taher, S. Ichwan, A. Bakhtiar, D. Arbain
In continuation of our study of Sumatran plants and the bioactivity of their constituents, Stereocaulon halei Lamb (Stereocaulaceae) was extracted and isolated to obtain atranorin ( 1 ), lobaric acid ( 6 ), and methyl- β -orcinol carboxylate ( 9 ). We also prepared methanolic extracts of some Sumatran medicinal plants, i.e. Alpinia denticulata, Alpinia malaccensis, Alpinia submutica, Curcuma zedoaria, Centella asiatia , Mangifera indica, Piper crocatum, Mussaenda frondosa , together with previously isolated compounds, i.e. crocatin A ( 2 ) and crocatin B ( 3 ) from P. crocatum , curcumin ( 4 ) from Curcuma longa , demethoxymatteucinol ( 5 ) from Sphaerostephanos polycarpus , mangiferin ( 7 ) from M. indica , methyl caffeate ( 8 ) from Balanophora elongata , tiliroside ( 10 ) from Guazuma ulmifolia , and usnic acid from Usnea sp ( 11 ). These extracts and compounds were tested for their cytotoxicity against MCF-7 and HSC-3 cell lines by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). It was found that the IC 50 value of atranorin ( 1 ), lobaric acid ( 6 ), methyl- β -orcinol carboxylate ( 9 ), and methanolic extract of A. submutica towards the MCF-7 cell line was 208.20 µM, 172.05 µM, 382.60 µM and 70.95 µg/mL, respectively. The IC 50 value of lobaric acid ( 6 ) and methyl-β-orcinol carboxylate ( 9 ) against the HSC-3 cell line was 88.92 µM and 260.09 µM, respectively. The other extracts did not show significant cytotoxicity.
{"title":"Cytotoxic Activities of Extracts and Isolated Compounds of Some Potential Sumatran Medicinal Plants against MCF-7 and HSC-3 Cell Lines","authors":"Meiridha Mutiara Andania, F. Ismed, M. Taher, S. Ichwan, A. Bakhtiar, D. Arbain","doi":"10.5614/j.math.fund.sci.2019.51.3.2","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2019.51.3.2","url":null,"abstract":"In continuation of our study of Sumatran plants and the bioactivity of their constituents, Stereocaulon halei Lamb (Stereocaulaceae) was extracted and isolated to obtain atranorin ( 1 ), lobaric acid ( 6 ), and methyl- β -orcinol carboxylate ( 9 ). We also prepared methanolic extracts of some Sumatran medicinal plants, i.e. Alpinia denticulata, Alpinia malaccensis, Alpinia submutica, Curcuma zedoaria, Centella asiatia , Mangifera indica, Piper crocatum, Mussaenda frondosa , together with previously isolated compounds, i.e. crocatin A ( 2 ) and crocatin B ( 3 ) from P. crocatum , curcumin ( 4 ) from Curcuma longa , demethoxymatteucinol ( 5 ) from Sphaerostephanos polycarpus , mangiferin ( 7 ) from M. indica , methyl caffeate ( 8 ) from Balanophora elongata , tiliroside ( 10 ) from Guazuma ulmifolia , and usnic acid from Usnea sp ( 11 ). These extracts and compounds were tested for their cytotoxicity against MCF-7 and HSC-3 cell lines by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). It was found that the IC 50 value of atranorin ( 1 ), lobaric acid ( 6 ), methyl- β -orcinol carboxylate ( 9 ), and methanolic extract of A. submutica towards the MCF-7 cell line was 208.20 µM, 172.05 µM, 382.60 µM and 70.95 µg/mL, respectively. The IC 50 value of lobaric acid ( 6 ) and methyl-β-orcinol carboxylate ( 9 ) against the HSC-3 cell line was 88.92 µM and 260.09 µM, respectively. The other extracts did not show significant cytotoxicity.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"6 1","pages":"225-242"},"PeriodicalIF":0.7,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84119065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.5614/j.math.fund.sci.2019.51.3.8
D. Hermanto, M. Mudasir, D. Siswanta, B. Kuswandi, N. Ismillayli
PEC of the alginate-chitosan membrane as supporting material for immobilizing urease was produced. This study aimed to develop a supporting material for enzyme immobilization that has high stability, a fast response time and an easy and relatively inexpensive preparation procedure. An alginate-chitosan PEC membrane was produced by reacting alginate hydrosol and chitosan (1:1 in mass) at pH 5.28, followed by mixing and drying at room temperature. The FTIR spectra, XRD patterns and SEM assay confirmed that alginate-chitosan PEC was obtained. The color change of the BTB indicator proved that urease was trapped in the cavities of the alginate-chitosan PEC membrane while the immobilized urease still showed catalytic activity. Thus, the membrane of alginate-chitosan PEC has good characteristics as a matrix for urease immobilization.
{"title":"Polyelectrolyte Complex (PEC) of the Alginate-Chitosan Membrane for Immobilizing Urease","authors":"D. Hermanto, M. Mudasir, D. Siswanta, B. Kuswandi, N. Ismillayli","doi":"10.5614/j.math.fund.sci.2019.51.3.8","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2019.51.3.8","url":null,"abstract":"PEC of the alginate-chitosan membrane as supporting material for immobilizing urease was produced. This study aimed to develop a supporting material for enzyme immobilization that has high stability, a fast response time and an easy and relatively inexpensive preparation procedure. An alginate-chitosan PEC membrane was produced by reacting alginate hydrosol and chitosan (1:1 in mass) at pH 5.28, followed by mixing and drying at room temperature. The FTIR spectra, XRD patterns and SEM assay confirmed that alginate-chitosan PEC was obtained. The color change of the BTB indicator proved that urease was trapped in the cavities of the alginate-chitosan PEC membrane while the immobilized urease still showed catalytic activity. Thus, the membrane of alginate-chitosan PEC has good characteristics as a matrix for urease immobilization.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":"1 1","pages":"309-319"},"PeriodicalIF":0.7,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83027981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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