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Effective Ayurvedic Management of Steroid Resistant Nephrotic Syndrome - Case Study 阿育吠陀疗法对类固醇抵抗性肾病综合征的有效治疗 - 案例研究
Pub Date : 2023-10-30 DOI: 10.18535/jmscr/v11i10.05
Dr Sarita Pradip Gaikwad
Nephrotic syndrome presents with heavy proteinuria (3.5 g Proteins/ 1.73 m2 body surface area/24 hour), dyslipidaemia/ hypercholesterolemia, hypoalbuminema, edema and hypertension. If left untreated or undiagnosed, there is progressive damage to glomeruli causing renal failure. Heavy proteinuria is the most characteristic feature of this syndrome. Several studies have noted that higher the 24-h urine protein excretion, more rapid is the decline in GFR. It may be primary or secondary to other systemic diseases. Case study: This 2 year old male child developed Nephrotic syndrome and was placed on steroids, used to relapse when steroids are withdrawn, and subsequently developed steroid resistance. He was poorly managed by modern line of treatment for last 10 years. The case had developed Cushingoid features due to long term use of steroids. This case was successfully managed by Ayurvedic treatment principles of Deepan-Pachan, Vatalunoman and Mutral chikitsa. Steroids were withdrawn gradually and completely. There was no relapse. He was free of proteinuria. His Cushingoid features disappeared. Edema and Ascites also disappeared. This case study is the example of importance of alternative medicine in treating steroid dependent/resistant cases. When modern treatment has definite limitations to treat such cases, it is ray of hope to thousands of poor sufferers of Steroid resistant Nephrotic syndrome, finding them an effective alternative of Ayurvedic treatment. Keywords: Nephrotic syndrome, Steroid resistance, Ayurvedic management, Dridamula Basti Shotha
肾病综合征表现为大量蛋白尿(3.5 克蛋白质/1.73 平方米体表面积/24 小时)、血脂异常/高胆固醇血症、低白蛋白血症、水肿和高血压。如果不及时治疗或诊断,肾小球会逐渐受损,导致肾功能衰竭。大量蛋白尿是该综合征的最大特征。一些研究指出,24 小时尿蛋白排泄量越高,肾小球滤过率下降越快。它可能是原发性的,也可能继发于其他系统疾病。病例研究:这名两岁的男童患上了肾病综合征,开始服用类固醇,停用类固醇后病情复发,随后出现类固醇耐药性。在过去的 10 年里,他的病情一直没有得到很好的控制。由于长期服用类固醇,该病例出现了库欣样特征。阿育吠陀疗法的 Deepan-Pachan、Vatalunoman 和 Mutral chikitsa 原则成功地治疗了该病例。类固醇被逐渐完全停用。病情没有复发。他没有了蛋白尿。他的库欣样特征消失了。水肿和腹水也消失了。本病例研究是替代医学在治疗类固醇依赖/耐药病例中的重要性的例证。当现代治疗方法在治疗此类病例时存在一定局限性时,它为成千上万的类固醇耐药肾病综合症患者带来了希望,为他们找到了阿育吠陀疗法这一有效的替代疗法。关键词肾病综合征、类固醇耐药性、阿育吠陀疗法、Dridamula Basti Shotha
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引用次数: 0
A Case Series on Clinical Profile, Risk Factors and Management of Idiopathic Intracranial Hypertension 特发性颅内高压的临床概况、风险因素和处理方法病例系列
Pub Date : 2023-10-30 DOI: 10.18535/jmscr/v11i10.14
Mohamed Saleem EK
Introduction Idiopathic intracranial hypertension (IIH) occurs when there is raised intracranial pressure (ICP) of unknown etiology and is diagnosed when all other causes of raised ICP have been excluded1 . IIH most commonly affects women of child-bearing age and overweight women2 . However, men, women of all ages and children of both genders are affected3 . Previously the terms like pseudo tumor cerebri and benign intracranial hypertension were used; however, in view of impending loss of vision it cannot be considered benign. Hence the term IIH is used nowadays. The diagnosis of IIH was made using modified Dandy criteria which includes presence of raised intracranial pressure, papilloedema, normal magnetic resonance imaging (MRI) and elevated CSF opening pressure with normal CSF composition. In the absence of papilledema, the diagnosis is challenging and requires specific neuroimaging criteria to be fulfilled.
导言 特发性颅内高压(IIH)是指病因不明的颅内压(ICP)升高,在排除了导致 ICP 升高的所有其他原因后才确诊1 。IIH 最常见于育龄妇女和超重妇女2 。不过,男性、所有年龄段的女性和儿童也会受到影响3 。以前曾使用假性脑肿瘤和良性颅内高压等术语,但鉴于即将丧失视力,不能将其视为良性疾病。因此,现在使用 IIH 一词。IIH 的诊断采用修改后的 Dandy 标准,包括颅内压升高、乳头水肿、磁共振成像(MRI)正常、CSF 打开压升高但 CSF 成分正常。如果没有乳头水肿,则诊断具有挑战性,需要符合特定的神经影像学标准。
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引用次数: 0
Initial Infarct location of Acute Stroke in Middle Cerebral Artery Circulation and Its Clinical Outcome using modified rank in scale 使用改良等级量表的大脑中动脉循环急性卒中的初始梗死位置及其临床结果
Pub Date : 2023-10-30 DOI: 10.18535/jmscr/v11i10.02
Fouz Parween P, Joy P Verghese, Brahmadathan MN
Abstract Introduction: Functional outcome after ischemic stroke is influenced by a variety of factors such as injured brain regions, extend and volume of the infarct. This study aim to correlate the infarct location and functional outcome of the patient. Materials and Method: This is a Prospective study done at MES Medical College, between December 2020 to June 2022, total 44 patients were admitted and taken MRI with a diagnosis of acute middle circulation ischemic stroke within 48 hours of symptom onset. Location of infarct is correlated with clinical outcome using a modified Rankin score taken at 45 days follow up. Results: Most of the infarct were located in the right hemisphere. A considerably high impact on functional outcome was found at the insula and surrounding opercular cortex.
摘要 简介:缺血性脑卒中后的功能预后受多种因素的影响,如受损脑区、梗死范围和体积。本研究旨在探讨梗死位置与患者功能预后的相关性。材料和方法:这是一项在 MES 医学院进行的前瞻性研究,在 2020 年 12 月至 2022 年 6 月期间,共有 44 名患者在症状出现 48 小时内入院并接受磁共振成像检查,诊断为急性中循环缺血性卒中。在 45 天的随访中使用改良的 Rankin 评分将梗死位置与临床结果联系起来。结果:大多数梗死位于右半球。岛叶和周围厣皮层对功能预后的影响相当大。
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引用次数: 0
Emperipolesis, Apoptosis and Hemophagocytosis during Acute Epstein-Barr Virus (EBV) infection: A Case Report 急性爱泼斯坦-巴氏病毒(EBV)感染期间的表皮松解、细胞凋亡和嗜血细胞增多:病例报告
Pub Date : 2023-09-30 DOI: 10.18535/jmscr/v11i9.03
B. Mehrotra
An eight-year-old patient had intermittent high grade fever and pharyngitis since one week. Later, he developed left-sided cervical lymphadenitis. Subsequently, he also developed palatal petechiae. Absolute lymphocyte count (ALC) was raised (ALC 20,262 cells/mm³). Hepatosplenomegaly was also detected. Clinically, the current case was diagnosed as a case of infectious mononucleosis. Possibility of infection by Epstein-Barr virus was considered. FNAC was done. Blood-mixed aspirate showed monocytoid cells with mild pleomorphic nuclei, and clumped chromatin. Inconspicuous nucleoli and abundant eosinophilic cytoplasm were seen. Foci of apoptosis were also seen. Frequent mitoses were seen. Findings were suggestive of acute reactive lymphocytic hyperplasia with hemophagocytosis and apoptosis. EBV DNA was detected by RT PCR with linear reporting range of 3.3×104 IU/ml. Herewith, we describe a case of infectious mononucleosis with emperipolesis and hemophagocytosis. Keywords: Epstein-Barr virus associated hemophagocytosis syndrome (EBVAHS).
一名八岁的患者从一周前开始出现间歇性高烧和咽炎。后来,他患上了左侧颈淋巴结炎。随后,他还出现了腭部瘀斑。绝对淋巴细胞计数(ALC)升高(ALC 20,262 cells/mm³)。此外,还发现肝脾肿大。临床诊断为传染性单核细胞增多症。考虑到可能感染了 Epstein-Barr 病毒。患者接受了 FNAC 检查。混血抽吸物显示单核细胞,核轻度多形,染色质成块。可见不明显的核仁和大量嗜酸性细胞质。还可见凋亡灶。可见频繁的有丝分裂。检查结果提示急性反应性淋巴细胞增生伴有嗜血细胞增多和凋亡。通过 RT PCR 检测到 EBV DNA,线性报告范围为 3.3×104 IU/ml。在此,我们描述了一例传染性单核细胞增多症伴有溢血和嗜血细胞增多的病例。关键词与爱泼斯坦-巴氏病毒相关的嗜血细胞增多综合征(EBVAHS)。
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引用次数: 0
Dual Left Ventricular Outflow Tract Obstruction Presenting in Old Age 老年期出现的双左心室流出道梗阻
Pub Date : 2023-09-30 DOI: 10.18535/jmscr/v11i9.01
Dr Priyanka Singh
Hypertrophic obstructive cardiomyopathy with Rheumatic heart disease, severe aortic stenosis and severe mitral stenosis is an uncommon presentation. Diagnosis ofdual left ventricular outflow tract obstructive physiology, caused by severe symptomatic obstructive hypertrophic cardiomyopathy and concomitant moderate or severe aortic stenosis is of paramount importance for management. (myectomy and aortic valve replacement). Our case, is a 67 years old hypertensive male presented with complain of chest pain, diffuse, radiating to left arm, associated with sweating and also with history of loss of consciousness.
肥厚型梗阻性心肌病伴有风湿性心脏病、重度主动脉瓣狭窄和重度二尖瓣狭窄是一种不常见的表现。由严重症状性梗阻性肥厚型心肌病和同时伴有中度或严重主动脉瓣狭窄引起的双左室流出道梗阻性生理学诊断对治疗至关重要。(主动脉瓣置换术)。我们的病例是一名 67 岁的男性高血压患者,主诉胸痛,弥漫性,向左臂放射,伴有出汗,还有意识丧失的病史。
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引用次数: 0
A Case of Acute Pancreatitis in Organophosphate Poisoning 一例有机磷中毒急性胰腺炎病例
Pub Date : 2023-09-30 DOI: 10.18535/jmscr/v11i9.11
Anoop Manish Chaudhary
Organophosphate (OP) poisoning is one of the most harmful and easily accessible pesticides for suicide poisoning. It is linked to high mortality and morbidity. Cholinergic syndrome, intermediate syndrome, and syndrome of delayed polyneuropathy are the three primary syndromes that characterize OP poisoning. Organophosphates are strong toxins that are frequently used as pesticides in agriculture. Patients who have consumed organophosphorus may exhibit subclinical symptoms of acute pancreatitis. Correct biochemical analysis and clinical correlation assist in diagnosis. In the study, we described a 24-year-old female who suffered necrotizing pancreatitis after OP poisoning. Keywords: Organophosphate Poisoning, Pesticide, Pancreatitis.
有机磷(OP)中毒是最有害、最容易引起自杀性中毒的农药之一。它与高死亡率和高发病率有关。胆碱能综合征、中间综合征和迟发性多发性神经病综合征是 OP 中毒的三种主要综合征。有机磷是一种强毒素,经常被用作农业杀虫剂。摄入有机磷的患者可能会表现出急性胰腺炎的亚临床症状。正确的生化分析和临床相关性有助于诊断。本研究描述了一名 24 岁女性在 OP 中毒后出现坏死性胰腺炎的病例。关键词:有机磷中毒有机磷中毒 杀虫剂 胰腺炎
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引用次数: 0
Associated Risk Factors with The Prevalence of Diabetes and Prediabetes in Gopalganj District 戈帕尔甘杰县糖尿病和糖尿病前期患病率的相关风险因素
Pub Date : 2023-09-30 DOI: 10.18535/jmscr/v11i9.06
Dr A. K. M. Azad Hossain
People's lifestyles are changing a lot with time. Busy working life, indifference to ideal living, addiction to yummy junk food and lack of physical activity are causing many health hazards. Due to changes in lifestyle and dietary habits, the prevalence of several diseases has increased, among which diabetes can be identified as one of them. Diabetes is a chronic disease that affects people of all ages. There are several forms of diabetes. Type 2 is the most common. The number of people in Bangladesh who have type-2 diabetes has increased dramatically making it one of the country's major health problems. The rising prevalence of diabetes in Bangladesh is associated with overweight, age, family history of diabetic, physical activity, eating habit of high carbs food etc. So, we collected 320 individuals affected or take medication or checks themselves in any Diabetic Center in Gopalganj district for treatment or any suggestions. The aim of the study is to explain the status of diabetes affected peoples on average result and to find out any certain factor which relates to the disease. The variables included the age of the patient, job category, exercise time, meal plan and some other important factor that is considered to be related to diabetes. The dependent variable was chosen as the blood glucose level of the respondents. We used chi-square test and logistic regression to find any significant relation that can be described. Logistic regression analysis identified some important factors that significantly affect the blood glucose level of the respondents, namely average sleep time, rice for breakfast, diet, red meat, smoking and age. Keywords: Food habits, Diabetes, blood glucose level, Chi-square test, Logistic regression.
随着时间的推移,人们的生活方式发生了很大变化。繁忙的工作、对理想生活的漠视、对美味垃圾食品的嗜好以及缺乏体育锻炼,这些都对健康造成了许多危害。由于生活方式和饮食习惯的改变,一些疾病的发病率有所上升,糖尿病就是其中之一。糖尿病是一种影响各个年龄段人群的慢性疾病。糖尿病有多种形式。2 型糖尿病最为常见。孟加拉国患有 2 型糖尿病的人数急剧增加,使其成为该国的主要健康问题之一。孟加拉国糖尿病发病率的上升与超重、年龄、糖尿病家族史、体育锻炼、高碳水化合物食物的饮食习惯等因素有关。因此,我们收集了 320 名受影响的人,他们或服用药物,或到戈帕尔甘杰区的任何一家糖尿病中心进行自我检查,以寻求治疗或任何建议。研究的目的是解释糖尿病患者的平均状况,并找出与该疾病相关的某些因素。变量包括患者的年龄、工作类别、运动时间、膳食计划和其他一些被认为与糖尿病有关的重要因素。因变量被选为受访者的血糖水平。我们使用了卡方检验和逻辑回归来寻找任何可以描述的重要关系。逻辑回归分析确定了对受访者血糖水平有明显影响的一些重要因素,即平均睡眠时间、早餐米饭、饮食、红肉、吸烟和年龄。关键词饮食习惯、糖尿病、血糖水平、卡方检验、逻辑回归。
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引用次数: 0
A Cross Sectional Study of Short Term Mortality Assessment of on Pump and Off Pump Cabg Groups with Left Main Coronary Artery Disease 左主干冠状动脉疾病开泵和不开泵组短期死亡率评估的横断面研究
Pub Date : 2023-09-30 DOI: 10.18535/jmscr/v11i9.17
Dr C. Sayee Sankar Vinod MD
Background: The main aim of the study is to investigate the prevelance of different risk factors, angiographic patterns undergoing cabg , the within 30 day mortality among cabg groups with left main coronary artery disease incidences and correlating them between on pump cabg group and off pump cabg group Methods: The present study is a retrospective cross sectional observational study with data from may 2016 to December 2021 undertaken in government general hospital Kurnool. The data considered includes the age, risk factors, echo reports, angiographic data, surgery details and post surgery status. Out of 108 CABG procedures done a total of 20 patients with LM disease where taken of which 10 on pump cabg group patients and 10 off pump cabg group patients where present eligible as per inclusion criteria and exclusion criteria
研究背景本研究的主要目的是调查不同危险因素的发生率、接受冠状动脉造影术的血管造影模式、冠状动脉造影术组与左主冠状动脉疾病发病率之间的 30 天内死亡率,以及开泵冠状动脉造影术组和非开泵冠状动脉造影术组之间的相关性:本研究是一项回顾性横断面观察研究,数据来源于库尔努尔政府综合医院2016年5月至2021年12月的数据。考虑的数据包括年龄、风险因素、回声报告、血管造影数据、手术细节和术后状况。在 108 例 CABG 手术中,共有 20 例 LM 患者,其中 10 例为使用泵的 CABG 组患者,10 例为不使用泵的 CABG 组患者。
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引用次数: 0
A Study of Correlation between Tear Film Break - Up Time (TBUT), Pterygium and Pinguicula on Patents Attending a Tertiary Centre, North Bengal Medical College & Hospital, Darjeeling, Sub Himalayan Region, India 泪膜破裂时间 (TBUT)、翼状胬肉与印度次喜马拉雅地区大吉岭北孟加拉医学院和医院三级医疗中心就诊患者胬肉之间的相关性研究
Pub Date : 2023-09-30 DOI: 10.18535/jmscr/v11i9.08
Dr Malabika Debbarma
Introduction: Degenerative changes in conjunctive are quite common in India, especially after 40 years of age. Degenerative changes like Pterygium and Pinguicula occurs especially due to prolonged exposure to ultra violet rays who lives in dry windy area and having pre-existing dry eye syndrome. Pterygium is a elastotic degeneration of the subconjunctival tissue approaches towards the cornea in a triangular fashion. Pterygium is mostly prevalent on the palpebral aperture mostly in the nasal side. It is thought that the predominantly nasal location is related to reflection of light from the nasal bridge on to the nasal conjunctiva. The ultraviolet light may be mediated by mutation in the P53 gene.
简介结膜退行性病变在印度很常见,尤其是在 40 岁以后。翼状胬肉和扁平丘疹等退行性病变主要发生在长期暴露于紫外线下、生活在干燥多风地区以及患有干眼症的人身上。翼状胬肉是结膜下组织的弹性变性,呈三角形向角膜靠近。翼状胬肉多发于睑孔,主要在鼻侧。一般认为,翼状胬肉主要发生在鼻侧与鼻梁上的光线反射到鼻结膜有关。紫外线可能是由 P53 基因突变介导的。
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引用次数: 0
Observational Study of Effectiveness of Ligation of Intersphinsteric Fistula Tract (Lift) in Perianal Fistulas Operated at AIIMS Patna 在巴特那 AIIMS 进行的肛周瘘手术中结扎瘘管间管(提升器)效果的观察研究
Pub Date : 2023-09-30 DOI: 10.18535/jmscr/v11i9.04
Dr Md Afsar Alam
Background: Perianal fistula or fistula-in-ano, is a chronic abnormal communication, usually lined by granulation tissue, which runs outwards from the anorectal lumen (the internalopening) to an external opening on the skin of the perineum and gluteal region. Perianal fistula develops as a result of anorectal sepsis. Ligation of intersphincteric fistula tract (LIFT) is a new sphincter saving method with good result in the management of fistula. The aim of study was to evaluate the effectiveness and functional outcomes of the LIFT patients operated at AIIMS Patna.
背景:肛周瘘或肛门瘘是一种慢性异常沟通,通常由肉芽组织衬里,从肛门直肠腔(内部开口)向外延伸至会阴和臀部皮肤的外部开口。肛门直肠败血症会导致肛周瘘。括约肌间瘘道结扎术(LIFT)是一种新的括约肌挽救方法,在治疗肛瘘方面效果良好。本研究旨在评估在巴特那印度医学研究院(AIIMS Patna)接受括约肌间瘘管结扎手术的患者的疗效和功能结果。
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引用次数: 0
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Journal of Medical Science And clinical Research
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