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Fractional-Order Generalized Thermoelastic Interaction in an Unbounded Media by Pulsed Laser Heating 脉冲激光加热无界介质中的分数阶广义热弹性相互作用
IF 1.5 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2016-11-28 DOI: 10.1142/S2251237316500027
A. Hobiny, I. Abbas
In this work, the influence of fractional-order derivative with two relaxation times in a thermoelastic medium under laser pulse is established. The surface of the half-space with free stresses is considered to be heated by a laser pulse. The exact analytical solution is adopted for the variations of temperature as well as the components of displacement and stress. Based on the eigenvalues approach and Laplace transform, the solutions of all variables have been obtained analytically. The results were graphically represented to show the effect of laser pulse in order to display the physical meaning of the phenomena. The graphical results indicate that the influence of fractional-order parameter plays an important role on all distributions.
本文研究了激光脉冲作用下热弹性介质中分数阶导数随两个弛豫时间变化的影响。具有自由应力的半空间表面被认为是由激光脉冲加热的。温度、位移分量和应力分量的变化均采用精确解析解。基于特征值法和拉普拉斯变换,得到了所有变量的解析解。将结果用图形表示,以显示激光脉冲的影响,以显示该现象的物理意义。图形结果表明,分数阶参数对所有分布的影响都很重要。
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引用次数: 0
Fabrication Techniques for Production of Thermoplastic-Based Microfluidics Devices 热塑性微流体器件的制造技术
IF 1.5 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2016-09-01 DOI: 10.1142/S2251237316400165
Zhenfeng Wang
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引用次数: 2
Quantification of Protein Biomarker Using SERS Nano-Stress Sensing with Peak Intensity Ratiometry 利用SERS纳米应力传感峰强度比法定量蛋白质生物标志物
IF 1.5 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2016-09-01 DOI: 10.1142/S2251237316400116
D. Goh, K. Kong, Perumal Jayakumar, Tianxun Gong, U. Dinish, M. Olivo
We report a surface enhanced Raman spectroscopy (SERS) ratiometry method based on peak intensity coupled in a nano-stress sensing platform to detect and quantify biological molecules. Herein, we em...
我们报道了一种基于峰值强度耦合纳米应力传感平台的表面增强拉曼光谱(SERS)比率法来检测和量化生物分子。在此,我们认为……
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引用次数: 2
Determination of DNA Binding Behavior of FoxA1 Constructs Using a Gold Nanoparticle-Based High Throughput Assay 利用基于金纳米粒子的高通量测定FoxA1构建体的DNA结合行为
IF 1.5 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2016-09-01 DOI: 10.1142/S2251237316400128
Khin Moh Moh Aung, M. Lim, Shuzhen Hong, E. Cheung, X. Su
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引用次数: 0
Plasmonic Responses in Metal Nanoslit Array Fabricated by Interference Lithography 干涉光刻技术制备金属纳米狭缝阵列的等离子体响应
IF 1.5 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2016-09-01 DOI: 10.1142/S2251237316400074
Nan Zhang, Lin Wu, P. Bai, J. Teng, W. Knoll, Xiaodong Zhou
Gap tunable gold nanoslit arrays were fabricated by interference lithography and investigated numerically to understand the impact of fabrication errors on plasmonic responses. To fabricate the gap tunable gold nanoslit arrays, photoresist nanoslit arrays on quartz substrate were first formed by laser interference, and then converted to gold nanoslit array on glass substrate by perpendicular gold deposition and photoresist lift-off. Because the photoresist nanoslit has a sinusoidal profile due to the laser light interference lithography, different photoresist development time from 20s to 30s can tune the photoresist width from 100nm to 70nm, thus allows the gap-width-tuned metallic nanoslits to be attained accordingly. The optical properties of the fabricated gold nanoslit arrays were investigated experimentally and theoretically by studying the absorption in the transmission spectra. Within the wavelength range of 400nm to 860nm, the nanoslit in air has two prominent absorption peaks at 500nm and 670nm. It is found that a simulation model with gold nanoslit fabrication errors such as size variation, chromium adhesive layer and gold residue in nanoslit gaps considered can better match the simulation peaks with the experiments. The simulation of the gold nanoslit array in air indicates that the 500nm peak includes the interband transition and surface plasmon polariton (SPP) at air-gold surface, and the other peak at 670nm is SPP at glass side. The two SPP peaks are both sensitive to the refractive index of surrounding solution, with sensitivities of the two peaks demonstrated to be 267nm/RIU and 111nm/RIU in experiments, and 462nm/RIU and 180nm/RIU by simulation. The lower sensitivity detected by experiments might be due to some air bubbles in the flow cell reducing the effective refractive index around the nanoslit. The shorter wavelength SPP mode is 2.4 (in experiments) or 2.6 times (by simulation) more sensitive than the long wavelength SPP mode because its plasmonic field concentrates on water-gold surface. The plasmonic responses we simulated with fabrication errors explained our experimental investigations, and deepened our understanding on the application of the gold nanoslit array for refractive index-based biosensing.
采用干涉光刻技术制备了间隙可调谐金纳米狭缝阵列,并通过数值模拟研究了制备误差对等离子体响应的影响。为了制备间隙可调金纳米狭缝阵列,首先通过激光干涉在石英衬底上形成光阻剂纳米狭缝阵列,然后通过垂直金沉积和光阻剂剥离将其转化为玻璃衬底上的金纳米狭缝阵列。由于激光干涉光刻导致光刻胶纳米狭缝呈正弦曲线,不同的光刻胶开发时间(20s ~ 30s)可以将光刻胶宽度从100nm调整到70nm,从而可以相应地获得间隙宽度可调的金属纳米狭缝。通过研究透射光谱中的吸收,对制备的金纳米狭缝阵列的光学特性进行了实验和理论研究。在400nm ~ 860nm波长范围内,空气中的纳米狭缝在500nm和670nm处有两个显著的吸收峰。研究发现,考虑金纳米缝尺寸变化、铬粘接层和金残留等制备误差的模拟模型能较好地与实验结果吻合。对空气中金纳米狭缝阵列的模拟表明,500nm处的峰包括空气金表面的带间跃迁和表面等离子激元极化子(SPP), 670nm处的另一个峰是玻璃侧的SPP。两个SPP峰均对周围溶液的折射率敏感,实验结果表明两个峰的灵敏度分别为267nm/RIU和111nm/RIU,仿真结果表明两个峰的灵敏度分别为462nm/RIU和180nm/RIU。实验检测到的低灵敏度可能是由于流动池内的气泡降低了纳米缝周围的有效折射率。短波长的SPP模式由于其等离子体场集中在水金表面,其灵敏度是长波SPP模式的2.4倍(实验结果)或2.6倍(模拟结果)。我们模拟的等离子体响应解释了我们的实验研究,加深了我们对金纳米狭缝阵列在折射率生物传感中的应用的理解。
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引用次数: 1
Determining ERβ Binding Affinity to Singly Mutant ERE Using Dual Polarization Interferometry 用双偏振干涉法测定ERβ与单突变ERE的结合亲和力
IF 1.5 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2016-09-01 DOI: 10.1142/S2251237316400086
H. Song, X. Su
In a classic mode of estrogen action, estrogen receptors (ERs) bind to estrogen responsive element (ERE) to activate gene transcription. A perfect ERE contains a 13-base pair sequence of a palindromic repeat separated by a three-base spacer, 5′-GGTCAnnnTGACC-3′. In addition to the consensus or wild-type ERE (wtERE), naturally occurring EREs often have one or two base pairs’ alternation. Based on the newly constructed Thermodynamic Modeling of ChIP-seq (TherMos) model, binding energy between ERβ and a series of 34-bp mutant EREs (mutERE) was simulated to predict the binding affinity between ERs and EREs with single base pair deviation at different sites of the 13-bp inverted sequence. Experimentally, dual polarization interferometry (DPI) method was developed to measure ERβ–mutEREs binding affinity. On a biotin-NeutrAvidin (NA)-biotin treated DPI chip, wtERE is immobilized. In a direct binding assay, ERβ–wtERE binding affinity is determined. In a competition assay, ERβ was preincubated with mutant EREs before being added for competitive binding to the immobilized wtERE. This competition strategy provided a successful platform to evaluate the binding affinity variation among large number of ERE with different base mutations. The experimental result correlates well with the mathematically predicted binding energy with a Spearman correlation coefficient of 0.97.
在雌激素的经典作用模式中,雌激素受体(er)结合雌激素反应元件(ERE)激活基因转录。一个完美的ERE包含一个13个碱基对的回文重复序列,由3个碱基间隔5 ' -GGTCAnnnTGACC-3 '分隔。除了共识型或野生型ERE (were)外,自然发生的ERE通常有一个或两个碱基对的交替。基于新建立的ChIP-seq热力学建模(TherMos)模型,模拟了ERβ与一系列34 bp突变体EREs (mutERE)之间的结合能,预测了ERβ与13 bp倒置序列不同位点单碱基对偏差的EREs之间的结合亲和力。实验上,建立了双偏振干涉法(DPI)来测量ERβ-mutEREs的结合亲和力。在生物素-中性生物素(NA)-生物素处理的DPI芯片上,固定化were。在直接结合试验中,确定了er β - were的结合亲和力。在竞争实验中,ERβ与突变体EREs预孵育,然后加入固定的were进行竞争结合。这种竞争策略为评估大量不同碱基突变的ERE之间的结合亲和力差异提供了一个成功的平台。实验结果与数学预测的结合能具有良好的相关性,Spearman相关系数为0.97。
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引用次数: 0
Interleukin-6 Detection with a Plasmonic Chip 等离子体芯片检测白细胞介素-6
IF 1.5 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2016-09-01 DOI: 10.1142/S2251237316400098
K. Tawa, M. Sumiya, M. Toma, Chisato Sasakawa, T. Sujino, Tatsuki Miyaki, H. Nakazawa, M. Umetsu
Interleukin-6, a cytokine relating inflammatory and autoimmune activity, was detected with three fluorescence assays using a plasmonic chip. In their assays, the way of surface modification, sample volume, incubation time and mixing solution, were found to influence the detection sensitivity. When the assay was revised in the point of a rapid and easy process, the detection sensitivity was not compromised compared to assays with sufficient sample volume and assay time. To suit the purpose of immunosensing, the assay conditions should be determined.
白细胞介素-6是一种与炎症和自身免疫活性相关的细胞因子,用等离子体芯片进行了三次荧光检测。结果表明,表面改性方式、样品体积、孵育时间和混合溶液对检测灵敏度有影响。当测定法在快速和简单的过程中进行修改时,与具有足够样本量和测定时间的测定法相比,检测灵敏度没有受到损害。为了适应免疫传感的目的,必须确定测定条件。
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引用次数: 0
Molecular Design of Bioinspired Nanostructures for Biomedical Applications: Synthesis, Self-Assembly and Functional Properties 生物医学应用的生物启发纳米结构的分子设计:合成、自组装和功能特性
IF 1.5 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2016-08-24 DOI: 10.1142/S2251237316400037
H. Xu, X. Zheng, Beverly Y. Mok, S. A. Ibrahim, Yong Yu, Y. Tan
Biomolecules are the nanoscale building blocks of cells, which play multifaceted roles in the critical biological processes such as biomineralization in a living organism. In these processes, the biological molecules such as protein and nucleic acids use their exclusive biorecognition properties enabled from their unique chemical composition, shape and function to initiate a cascade of cellular events. The exceptional features of these biomolecules, coupled with the recent advancement in nanotechnology, have led to the emergence of a new research field that focuses on the molecular design of bioinspired nanostructures that inherit the extraordinary function of natural biomaterials. These “bioinspired” nanostructures could be formulated by biomimetic approaches through either self-assembling of biomolecules or acting as a biomolecular template/precursor to direct the synthesis of nanocomposite. In either situation, the resulting nanomaterials exhibit phenomenal biocompatibility, superb aqueous solubility and excellent colloidal stability, branding them exceptionally desirable for both in vitro and in vivo biomedical applications. In this review, we will present the recent developments in the preparation of “bioinspired” nanostructures through biomimetic self-assembly and biotemplating synthesis, as well as highlight their functional properties and potential applications in biomedical diagnostics and therapeutic delivery. Lastly, we will conclude this topic with some personal perspective on the challenges and future outlooks of the “bioinspired” nanostructures for nanomedicine.
生物分子是细胞的纳米级构建单元,在生物体的生物矿化等关键生物过程中起着多方面的作用。在这些过程中,蛋白质和核酸等生物分子利用其独特的化学组成、形状和功能所赋予的独特的生物识别特性来启动一系列细胞事件。这些生物分子的独特特性,加上最近纳米技术的进步,导致了一个新的研究领域的出现,该领域的重点是生物启发纳米结构的分子设计,继承了天然生物材料的非凡功能。这些“受生物启发”的纳米结构可以通过生物分子的自组装或作为生物分子模板/前体来指导纳米复合材料的合成,通过仿生方法来制定。在任何一种情况下,所得到的纳米材料都表现出惊人的生物相容性,极好的水溶性和优异的胶体稳定性,使它们在体外和体内生物医学应用中都非常理想。在本文中,我们将介绍通过仿生自组装和生物模板合成制备“仿生”纳米结构的最新进展,以及它们的功能特性和在生物医学诊断和治疗递送方面的潜在应用。最后,我们将对纳米医学中“生物启发”纳米结构的挑战和未来展望进行一些个人观点的总结。
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引用次数: 11
Materializing Heart Regeneration: Biomimicry of Key Observations in Cell Transplantation Therapies and Natural Cardiac Regeneration 实现心脏再生:细胞移植治疗和自然心脏再生的关键观察的仿生学
IF 1.5 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2016-08-24 DOI: 10.1142/S2251237316400025
Y. Kong, Leenaporn Jongpaiboonkit
New regenerative paradigms are needed to address the growing global problem of heart failure as existing interventions are unsatisfactory. Outcomes from the current paradigm of cell transplantation have not been stellar but the mechanistic knowledge learned from them is instructive in the development of future paradigms. An emerging biomaterial-based approach incorporating key mechanisms and additional ones scrutinized from the process of natural heart regeneration in zebrafish may become the next evolution in cardiac repair. We highlight, with examples, tested key concepts and pivotal ones that may be integrated into a successful therapy.
由于现有的干预措施不能令人满意,需要新的再生范例来解决日益严重的全球心力衰竭问题。目前的细胞移植模式的结果并不理想,但从中学到的机制知识对未来模式的发展具有指导意义。一种新兴的基于生物材料的方法,结合了斑马鱼自然心脏再生过程中的关键机制和附加机制,可能成为心脏修复的下一个发展方向。我们强调,通过例子,测试的关键概念和关键的可能整合到一个成功的治疗。
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引用次数: 0
Bioinspired Composite Materials: Applications in Diagnostics and Therapeutics 生物激发复合材料:在诊断和治疗中的应用
IF 1.5 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2016-08-24 DOI: 10.1142/S2251237316400049
Alisha Prasad, Kuldeep Mahato, Pranjal Chandra, Ananya Srivastava, S. N. Joshi, P. Maurya
Evolution-optimized specimens from nature with inimitable properties, and unique structure–function relationships have long served as a source of inspiration for researchers all over the world. For instance, the micro/nanostructured patterns of lotus-leaf and gecko feet helps in self-cleaning, and adhesion, respectively. Such unique properties shown by creatures are results of billions of years of adaptive transformation, that have been mimicked by applying both science and engineering concepts to design bioinspired materials. Various bioinspired composite materials have been developed based on biomimetic principles. This review presents the latest developments in bioinspired materials under various categories with emphasis on diagnostic and therapeutic applications.
来自自然界的进化优化标本具有独特的特性和独特的结构-功能关系,长期以来一直是世界各地研究人员的灵感来源。例如,荷叶和壁虎脚的微/纳米结构模式分别有助于自清洁和粘附。生物表现出的这种独特特性是数十亿年的适应性转变的结果,这种转变已经被应用科学和工程概念来设计生物灵感材料所模仿。基于仿生原理,各种仿生复合材料已经被开发出来。本文综述了生物激发材料在各个领域的最新进展,重点介绍了生物激发材料在诊断和治疗方面的应用。
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引用次数: 22
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Journal of Molecular and Engineering Materials
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