首页 > 最新文献

Journal of medicinal food最新文献

英文 中文
A Review of the Effects of Flavonoids on NAD(P)H Quinone Oxidoreductase 1 Expression and Activity.
IF 1.7 3区 农林科学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2025-03-17 DOI: 10.1089/jmf.2023.0132
Erik B Froyen, Gianluis Pimentel Barrantes

Cancer is a significant cause of death worldwide. It has been suggested that the consumption of flavonoids decreases the risk for cancer by increasing phase II enzymes, such as Nicotinamide Adenine Dinucleotide Phosphate Hydrogen (NAD(P)H) quinone oxidoreductase 1 (NQO1), glutathione S-transferases, and Uridine 5'-diphospho- (UDP)-glucuronosyltransferases that assist in removing carcinogens from the human body. Flavonoids are bioactive compounds found in a variety of dietary sources, including fruits, vegetables, legumes, nuts, and teas. As such, it is important to investigate which flavonoids are involved in the metabolism of carcinogens to help reduce the risk of cancer. Therefore, the objective of this narrative review was to investigate the effects of commonly consumed flavonoids on NQO1 mRNA expression, protein, and activity in human cell and murine models. PubMed was used to search for peer-reviewed journal articles, which demonstrated that selected flavonoids (e.g., quercetin, apigenin, luteolin, genistein, and daidzein) increase NQO1, and therefore, increase the excretion of carcinogens. However, more research is needed regarding the mechanisms by which flavonoids induce NQO1. Furthermore, it is suggested that future efforts focus on providing precise flavonoid recommendations to decrease the risk factors for chronic diseases.

{"title":"A Review of the Effects of Flavonoids on NAD(P)H Quinone Oxidoreductase 1 Expression and Activity.","authors":"Erik B Froyen, Gianluis Pimentel Barrantes","doi":"10.1089/jmf.2023.0132","DOIUrl":"https://doi.org/10.1089/jmf.2023.0132","url":null,"abstract":"<p><p>Cancer is a significant cause of death worldwide. It has been suggested that the consumption of flavonoids decreases the risk for cancer by increasing phase II enzymes, such as Nicotinamide Adenine Dinucleotide Phosphate Hydrogen (NAD(P)H) quinone oxidoreductase 1 (NQO1), glutathione S-transferases, and Uridine 5'-diphospho- (UDP)-glucuronosyltransferases that assist in removing carcinogens from the human body. Flavonoids are bioactive compounds found in a variety of dietary sources, including fruits, vegetables, legumes, nuts, and teas. As such, it is important to investigate which flavonoids are involved in the metabolism of carcinogens to help reduce the risk of cancer. Therefore, the objective of this narrative review was to investigate the effects of commonly consumed flavonoids on NQO1 mRNA expression, protein, and activity in human cell and murine models. PubMed was used to search for peer-reviewed journal articles, which demonstrated that selected flavonoids (<i>e.g.</i>, quercetin, apigenin, luteolin, genistein, and daidzein) increase NQO1, and therefore, increase the excretion of carcinogens. However, more research is needed regarding the mechanisms by which flavonoids induce NQO1. Furthermore, it is suggested that future efforts focus on providing precise flavonoid recommendations to decrease the risk factors for chronic diseases.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypoglycemic Effect of Black Tea and Its Mechanism: Regulation of Glycometabolism and Intestinal Flora.
IF 1.7 3区 农林科学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2025-03-07 DOI: 10.1089/jmf.2024.k.0251
Fanglan Li, Hui Zhou, Jiangxiong Zhu, Xinlin Wei, Yuanfeng Wang

This study aimed to investigate the hypoglycemic effects of different concentrations of black tea (BT) extracts and their underlying mechanisms in type 2 diabetic (T2DM) mice. Results indicated that BT extracts significantly mitigated weight loss, improved glucose and insulin tolerance, and modulated cytokine levels related to glucose and lipid metabolism in T2DM mice. Moreover, BT extracts ameliorated liver and pancreas damage resulting from high-sugar/high-fat diets and insulin resistance. Among the tested concentrations, low-concentration BT (BT-L) extract exhibited the most potent hypoglycemic ability. Furthermore, BT-L restored pancreatic function in hyperglycemic mice via activating the glucagon-like peptide-1 receptor-protein kinase A-pancreatic and duodenal homeobox-1-glucokinase cascade pathway. In terms of intestinal homeostasis, all BT-treated groups adjusted the gut microbiota structure by regulating the distribution and diversity of gut microbiota in T2DM mice. Among them, BT-L intervention specifically and significantly increased the levels of probiotic Bifidobacterium in the intestine of T2DM mice. Furthermore, BT-L intervention effectively promoted the synthesis of streptomycin by gut microbiota, thereby exerting anti-inflammatory effect. Comprehensively, the hypoglycemic effect of BT cannot show an absolute concentration-dependent relationship. Our findings highlight the potential of BT as an effective blood glucose regulator and provide valuable insights for BT-based functional food development.

{"title":"Hypoglycemic Effect of Black Tea and Its Mechanism: Regulation of Glycometabolism and Intestinal Flora.","authors":"Fanglan Li, Hui Zhou, Jiangxiong Zhu, Xinlin Wei, Yuanfeng Wang","doi":"10.1089/jmf.2024.k.0251","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0251","url":null,"abstract":"<p><p>This study aimed to investigate the hypoglycemic effects of different concentrations of black tea (BT) extracts and their underlying mechanisms in type 2 diabetic (T2DM) mice. Results indicated that BT extracts significantly mitigated weight loss, improved glucose and insulin tolerance, and modulated cytokine levels related to glucose and lipid metabolism in T2DM mice. Moreover, BT extracts ameliorated liver and pancreas damage resulting from high-sugar/high-fat diets and insulin resistance. Among the tested concentrations, low-concentration BT (BT-L) extract exhibited the most potent hypoglycemic ability. Furthermore, BT-L restored pancreatic function in hyperglycemic mice via activating the glucagon-like peptide-1 receptor-protein kinase A-pancreatic and duodenal homeobox-1-glucokinase cascade pathway. In terms of intestinal homeostasis, all BT-treated groups adjusted the gut microbiota structure by regulating the distribution and diversity of gut microbiota in T2DM mice. Among them, BT-L intervention specifically and significantly increased the levels of probiotic <i>Bifidobacterium</i> in the intestine of T2DM mice. Furthermore, BT-L intervention effectively promoted the synthesis of streptomycin by gut microbiota, thereby exerting anti-inflammatory effect. Comprehensively, the hypoglycemic effect of BT cannot show an absolute concentration-dependent relationship. Our findings highlight the potential of BT as an effective blood glucose regulator and provide valuable insights for BT-based functional food development.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective Effects of Lilium Lancifolium Thunberg Extract Against Corticosterone-Induced Dysfunctions in PC12 Cells.
IF 1.7 3区 农林科学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2025-03-07 DOI: 10.1089/jmf.2024.k.0241
Jisu Lee, Jiwon Choi, Hea-Yeon Yun, Hyunsoo Jang, Minseo Cho, Jung-Heun Ha, Yoonhwa Jeong

Chronic stress in the central nervous system can lead to neurological dysfunction characterized by spontaneous neuronal cell death. This study investigated the neuroprotective potential of an aqueous extract of Lilium lancifolium Thunberg (ELL) against corticosterone (CORT)-induced pathophysiology in PC12 cells. To assess the neuroprotective effects of ELL, PC12 cells were pretreated with 50 µg/mL of ELL before being exposed to CORT. ELL significantly prevented CORT-induced neuronal cell death by attenuating pro-apoptotic protein expression, lactate dehydrogenase release, and reactive oxygen species generation, while maintaining intact adenosine triphosphate levels. Furthermore, ELL significantly mitigated CORT-induced endoplasmic reticulum (ER) stress responses by attenuating the elevation of unfolded protein responses, intracellular calcium levels, opening of mitochondrial permeability transition pores, and loss of mitochondrial membrane potential. In conclusion, ELL exerts neuroprotective effects by inhibiting apoptosis through the mitigation of CORT-induced ER stress and mitochondrial dysfunction, suggesting that ELL may prevent neuronal damage associated with chronic stress-induced neurotoxicity.

{"title":"Neuroprotective Effects of <i>Lilium Lancifolium</i> Thunberg Extract Against Corticosterone-Induced Dysfunctions in PC12 Cells.","authors":"Jisu Lee, Jiwon Choi, Hea-Yeon Yun, Hyunsoo Jang, Minseo Cho, Jung-Heun Ha, Yoonhwa Jeong","doi":"10.1089/jmf.2024.k.0241","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0241","url":null,"abstract":"<p><p>Chronic stress in the central nervous system can lead to neurological dysfunction characterized by spontaneous neuronal cell death. This study investigated the neuroprotective potential of an aqueous extract of <i>Lilium lancifolium</i> Thunberg (ELL) against corticosterone (CORT)-induced pathophysiology in PC12 cells. To assess the neuroprotective effects of ELL, PC12 cells were pretreated with 50 <i>µ</i>g/mL of ELL before being exposed to CORT. ELL significantly prevented CORT-induced neuronal cell death by attenuating pro-apoptotic protein expression, lactate dehydrogenase release, and reactive oxygen species generation, while maintaining intact adenosine triphosphate levels. Furthermore, ELL significantly mitigated CORT-induced endoplasmic reticulum (ER) stress responses by attenuating the elevation of unfolded protein responses, intracellular calcium levels, opening of mitochondrial permeability transition pores, and loss of mitochondrial membrane potential. In conclusion, ELL exerts neuroprotective effects by inhibiting apoptosis through the mitigation of CORT-induced ER stress and mitochondrial dysfunction, suggesting that ELL may prevent neuronal damage associated with chronic stress-induced neurotoxicity.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flavonoid Derivatives Isolated from Hypericum monogynum Ameliorate Insulin Resistance via Modulation of IRS-1/PI3K/Akt/FOXO1 Pathway in HepG2 Cells. 金丝桃黄酮衍生物通过调节IRS-1/PI3K/Akt/FOXO1通路改善HepG2细胞的胰岛素抵抗。
IF 1.7 3区 农林科学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2025-03-01 Epub Date: 2024-12-23 DOI: 10.1089/jmf.2024.k.0242
Seungjoo Baik, Yunhua Qianshi, Samuel Park, Hana Lee, Huijin Heo, Junsoo Lee, Chunmao Yuan, Jeehye Sung

In this study, two high-content flavonoid derivatives [3-8 biapigenin (HM 104) and quercetin-3-O-β-d-galactopyranoside (HM 111)] were obtained through the bioactivity-guided isolation of antidiabetic compounds from Hypericum monogynum flowers. HM 104 and HM 111 exhibited good glucose consumption in fatty acid-induced insulin-resistant HepG2 cells. Moreover, both active compounds enhanced glucose uptake by restoring the expression of key regulators of glucose metabolism, including insulin receptor substrate 1, phosphoinositide 3-kinase, protein kinase B, and glucose transporter type 4, and by mitigating the expression of forkhead box O1 and the factors involved in gluconeogenesis. They upregulate the phosphorylation of glycogen synthase kinase-3β, which may affect glycogen synthesis. Furthermore, the production of reactive oxygen species was decreased by the two compounds. This study provides novel mechanistic insights into the protective effects of flavonoid derivatives isolated from H. monogynum flowers in preventing and managing insulin resistance and associated metabolic disorders.

本研究通过生物活性引导从金丝桃花中分离抗糖尿病化合物,获得了两种高含量的类黄酮衍生物[3-8双芹菜素(HM 104)和槲皮素-3- o -β-d-半胱甘肽(HM 111)]。hm104和hm111在脂肪酸诱导的胰岛素抵抗HepG2细胞中表现出良好的葡萄糖消耗。此外,这两种活性化合物通过恢复葡萄糖代谢的关键调控因子的表达,包括胰岛素受体底物1、磷酸肌肽3-激酶、蛋白激酶B和葡萄糖转运蛋白4型,以及减轻叉头盒O1和糖异生相关因子的表达,从而增强葡萄糖摄取。它们上调糖原合成酶激酶-3β的磷酸化,这可能影响糖原的合成。此外,这两种化合物还减少了活性氧的生成。本研究为从花中分离的黄酮类衍生物在预防和管理胰岛素抵抗和相关代谢紊乱中的保护作用提供了新的机制见解。
{"title":"Flavonoid Derivatives Isolated from <i>Hypericum monogynum</i> Ameliorate Insulin Resistance via Modulation of IRS-1/PI3K/Akt/FOXO1 Pathway in HepG2 Cells.","authors":"Seungjoo Baik, Yunhua Qianshi, Samuel Park, Hana Lee, Huijin Heo, Junsoo Lee, Chunmao Yuan, Jeehye Sung","doi":"10.1089/jmf.2024.k.0242","DOIUrl":"10.1089/jmf.2024.k.0242","url":null,"abstract":"<p><p>In this study, two high-content flavonoid derivatives [3-8 biapigenin (HM 104) and quercetin-3-<i>O</i>-β-<i>d</i>-galactopyranoside (HM 111)] were obtained through the bioactivity-guided isolation of antidiabetic compounds from <i>Hypericum monogynum</i> flowers. HM 104 and HM 111 exhibited good glucose consumption in fatty acid-induced insulin-resistant HepG2 cells. Moreover, both active compounds enhanced glucose uptake by restoring the expression of key regulators of glucose metabolism, including insulin receptor substrate 1, phosphoinositide 3-kinase, protein kinase B, and glucose transporter type 4, and by mitigating the expression of forkhead box O1 and the factors involved in gluconeogenesis. They upregulate the phosphorylation of glycogen synthase kinase-3β, which may affect glycogen synthesis. Furthermore, the production of reactive oxygen species was decreased by the two compounds. This study provides novel mechanistic insights into the protective effects of flavonoid derivatives isolated from <i>H. monogynum</i> flowers in preventing and managing insulin resistance and associated metabolic disorders.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"243-255"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chrysanthemum Zawadskii Var. and Platycodon Grandifloras Extract Mixture Protects Against Lipopolysaccharide-Induced Pulmonary Inflammation and Cyclophosphamide-Induced Immune Deficiency: In Vivo Evidence. 菊花和桔梗提取物混合物对脂多糖诱导的肺部炎症和环磷酰胺诱导的免疫缺陷的体内证据。
IF 1.7 3区 农林科学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2025-03-01 Epub Date: 2025-01-06 DOI: 10.1089/jmf.2024.k.0245
Dong-Uk Jo, Yongeun Kim, Heejin Ko, Sujung Hong, Wonchul Lim, Tae-Gyu Lim

Respiratory tract diseases (RTDs) cause airflow limitations and impaired respiratory function, primarily due to pulmonary inflammation and immune dysfunction. Chrysanthemum zawadskii var. latilobum Kitamur and Platycodon grandifloras (CP) are traditional herbs known for their anti-inflammatory and immune-enhancing properties. This study investigates the anti-inflammatory and immune-enhancing effects of a combined extract of CP in vivo. CP was prepared by mixing equal volumes of Chrysanthemum zawadskii extract (CE) and Platycodon grandifloras extract (PE) at the same concentration. The anti-inflammatory effects of CP were evaluated using a lipopolysaccharide (LPS)-induced inflammation model in BALB/c mice. The immune-enhancing effects were assessed using a cyclophosphamide (CYP)-induced immunosuppression model. Protein and mRNA expressions of inflammatory and immune markers were analyzed through Western blotting and quantitative real-time PCR. CP significantly reduced LPS-induced pulmonary inflammation by decreasing interleukin (IL)-1β and cyclooxygenase-2 expression in lung tissues. In the CYP-induced model, CP treatment restored spleen and thymus weights, reversed reductions in immune cell counts, and increased TNF-α and IL-2 mRNA expression in the spleen. In conclusion, CP inhibits pulmonary inflammation by suppressing inflammatory mediators and enhances immune function by increasing immune-related indicators. This suggests that CP may have potential therapeutic applications for treating respiratory inflammation and related diseases.

呼吸道疾病(rtd)引起气流受限和呼吸功能受损,主要是由于肺部炎症和免疫功能障碍。菊花(zawadskii varo . latilobum Kitamur)和桔梗(Platycodon grandfloras)是传统的草药,以其抗炎和增强免疫功能而闻名。本研究探讨了CP联合提取物在体内的抗炎和免疫增强作用。将菊花提取物(CE)和桔梗提取物(PE)以等体积、相同浓度混合制备CP。采用脂多糖(LPS)诱导的BALB/c小鼠炎症模型,评价CP的抗炎作用。采用环磷酰胺(CYP)诱导的免疫抑制模型评估免疫增强作用。通过Western blotting和实时荧光定量PCR分析炎症和免疫标志物的蛋白和mRNA表达。CP通过降低肺组织中白细胞介素(IL)-1β和环氧化酶-2的表达,显著减轻lps诱导的肺部炎症。在cyp诱导的模型中,CP处理恢复了脾脏和胸腺的重量,逆转了免疫细胞计数的减少,并增加了脾脏中TNF-α和IL-2 mRNA的表达。综上所述,CP通过抑制炎症介质抑制肺部炎症,通过增加免疫相关指标增强免疫功能。这表明CP可能在治疗呼吸道炎症和相关疾病方面具有潜在的治疗应用。
{"title":"<i>Chrysanthemum Zawadskii</i> Var. and <i>Platycodon Grandifloras</i> Extract Mixture Protects Against Lipopolysaccharide-Induced Pulmonary Inflammation and Cyclophosphamide-Induced Immune Deficiency: <i>In Vivo</i> Evidence.","authors":"Dong-Uk Jo, Yongeun Kim, Heejin Ko, Sujung Hong, Wonchul Lim, Tae-Gyu Lim","doi":"10.1089/jmf.2024.k.0245","DOIUrl":"10.1089/jmf.2024.k.0245","url":null,"abstract":"<p><p>Respiratory tract diseases (RTDs) cause airflow limitations and impaired respiratory function, primarily due to pulmonary inflammation and immune dysfunction. <i>Chrysanthemum zawadskii</i> var. <i>latilobum</i> Kitamur and <i>Platycodon grandifloras</i> (CP) are traditional herbs known for their anti-inflammatory and immune-enhancing properties. This study investigates the anti-inflammatory and immune-enhancing effects of a combined extract of CP <i>in vivo</i>. CP was prepared by mixing equal volumes of <i>Chrysanthemum zawadskii</i> extract (CE) and <i>Platycodon grandifloras</i> extract (PE) at the same concentration. The anti-inflammatory effects of CP were evaluated using a lipopolysaccharide (LPS)-induced inflammation model in BALB/c mice. The immune-enhancing effects were assessed using a cyclophosphamide (CYP)-induced immunosuppression model. Protein and mRNA expressions of inflammatory and immune markers were analyzed through Western blotting and quantitative real-time PCR. CP significantly reduced LPS-induced pulmonary inflammation by decreasing interleukin (IL)-1β and cyclooxygenase-2 expression in lung tissues. In the CYP-induced model, CP treatment restored spleen and thymus weights, reversed reductions in immune cell counts, and increased TNF-α and IL-2 mRNA expression in the spleen. In conclusion, CP inhibits pulmonary inflammation by suppressing inflammatory mediators and enhances immune function by increasing immune-related indicators. This suggests that CP may have potential therapeutic applications for treating respiratory inflammation and related diseases.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"256-265"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenylethanol Glycosides from Cistanche tubulosa Modulate the Gut Microbiota and Cecal Metabolites to Ameliorate Diabetic Nephropathy Induced by Streptozotocin Combined with High-Fat Diet in Rats. 肉苁蓉中的苯乙醇苷调节肠道微生物群和盲肠代谢物,改善链脲佐菌素联合高脂饮食诱导的大鼠糖尿病肾病
IF 1.7 3区 农林科学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2025-03-01 Epub Date: 2024-10-14 DOI: 10.1089/jmf.2024.k.0175
Chong Ma, Bowei Ju, Jiangyun Liu, Limei Wen, Yao Zhao, Jianhua Yang, Junping Hu

Diabetic nephropathy (DN) is a prevalent complication and serious microvascular of diabetes mellitus. After previous studies, we found that phenylethanol glycosides (CPhGs) derived from Cistanche tubulosa (Schenk) Wight exerts antidiabetic and renoprotective effects. However, the effects of CPhGs on DN remain incompletely understood. The study aimed to examine the effects of CPhGs on DN in rats and explore the underlying mechanism involved. A DN rat model was established by streptozotocin (STZ) combined with a high-fat diet. Reagent kits were used to assess the extent to which CPhGs ameliorate hyperglycemia, insulin resistance (IR), renal dysfunction, kidney oxidative stress, and peripheral inflammation. Histology and immunohistochemical staining were used to detect the changes in renal tissue structure and the expression levels of α-smooth muscle actin (α-SMA) and collagen I. Furthermore, we analyzed the cecal contents of DN rats to investigate the effect of CPhGs on gut microbiota by using 16S rRNA sequencing and broad-spectrum metabolite profiling. The results showed that CPhGs demonstrated a range of advantageous outcomes in DN, encompassing the enhancement of kidney function and alleviation of hyperglycemia, IR, renal injury, oxidative stress, and peripheral inflammatory reactions. In addition, CPhGs regulated the abundance of the [Eubacterium]_coprostanoligenes_group, Oscillospiraceae_UCG-005, etc. to modulate the gut microbiota. CPhGs significantly upregulated the content of vitamin B6 and tyrosyl-tryptophan and downregulated histamine, L-methionine, etc. In summary, the therapeutic efficacy of CPhGs on DN rats may be achieved by modulating the gut microbiota and cecal metabolites to restore the metabolic disorders of vitamin B6, histidine, etc.

糖尿病肾病(DN)是糖尿病的一种常见并发症和严重的微血管疾病。经过先前的研究,我们发现从肉苁蓉(Schenk)Wight 中提取的苯乙醇苷(CPhGs)具有抗糖尿病和保护肾脏的作用。然而,CPhGs 对 DN 的影响仍不完全清楚。本研究旨在考察 CPhGs 对大鼠 DN 的影响,并探索其潜在机制。通过链脲佐菌素(STZ)结合高脂饮食建立了 DN 大鼠模型。试剂盒用于评估 CPhGs 对高血糖、胰岛素抵抗(IR)、肾功能障碍、肾脏氧化应激和外周炎症的改善程度。此外,我们还利用 16S rRNA 测序和广谱代谢物谱分析技术分析了 DN 大鼠的盲肠内容物,以研究 CPhGs 对肠道微生物群的影响。结果表明,CPhGs 对 DN 有一系列有利影响,包括增强肾功能,缓解高血糖、IR、肾损伤、氧化应激和外周炎症反应。此外,CPhGs 还能调节[Eubacterium]_coprostanoligenes_group、Oscillospiraceae_UCG-005 等的丰度,从而调节肠道微生物群。CPhGs 能明显提高维生素 B6 和酪氨酸色氨酸的含量,降低组胺、L-蛋氨酸等的含量。综上所述,CPhGs 对 DN 大鼠的疗效可能是通过调节肠道微生物群和盲肠代谢物来恢复维生素 B6、组氨酸等代谢紊乱。
{"title":"Phenylethanol Glycosides from <i>Cistanche tubulosa</i> Modulate the Gut Microbiota and Cecal Metabolites to Ameliorate Diabetic Nephropathy Induced by Streptozotocin Combined with High-Fat Diet in Rats.","authors":"Chong Ma, Bowei Ju, Jiangyun Liu, Limei Wen, Yao Zhao, Jianhua Yang, Junping Hu","doi":"10.1089/jmf.2024.k.0175","DOIUrl":"10.1089/jmf.2024.k.0175","url":null,"abstract":"<p><p>Diabetic nephropathy (DN) is a prevalent complication and serious microvascular of diabetes mellitus. After previous studies, we found that phenylethanol glycosides (CPhGs) derived from <i>Cistanche tubulosa</i> (Schenk) Wight exerts antidiabetic and renoprotective effects. However, the effects of CPhGs on DN remain incompletely understood. The study aimed to examine the effects of CPhGs on DN in rats and explore the underlying mechanism involved. A DN rat model was established by streptozotocin (STZ) combined with a high-fat diet. Reagent kits were used to assess the extent to which CPhGs ameliorate hyperglycemia, insulin resistance (IR), renal dysfunction, kidney oxidative stress, and peripheral inflammation. Histology and immunohistochemical staining were used to detect the changes in renal tissue structure and the expression levels of α-smooth muscle actin (α-SMA) and collagen I. Furthermore, we analyzed the cecal contents of DN rats to investigate the effect of CPhGs on gut microbiota by using 16S rRNA sequencing and broad-spectrum metabolite profiling. The results showed that CPhGs demonstrated a range of advantageous outcomes in DN, encompassing the enhancement of kidney function and alleviation of hyperglycemia, IR, renal injury, oxidative stress, and peripheral inflammatory reactions. In addition, CPhGs regulated the abundance of the <i>[Eubacterium]_coprostanoligenes_</i>group, <i>Oscillospiraceae_UCG-005</i>, etc. to modulate the gut microbiota. CPhGs significantly upregulated the content of vitamin B6 and tyrosyl-tryptophan and downregulated histamine, L-methionine, etc. In summary, the therapeutic efficacy of CPhGs on DN rats may be achieved by modulating the gut microbiota and cecal metabolites to restore the metabolic disorders of vitamin B6, histidine, etc.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"219-231"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperomocysteinemia in an Unselected Female Population: Incidence and Treatment Options. 高半胱氨酸血症在未选择的女性人群:发病率和治疗方案。
IF 1.7 3区 农林科学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2025-03-01 Epub Date: 2024-11-29 DOI: 10.1089/jmf.2024.0214
Francesca Manganello, Giuseppe Mungo, Donatella Rettore, Esther Otaño Ruiz, Antonio Frungillo

Homocysteine (HCys) is a sulfur-containing amino acid involved in the conversion of methionine to cysteine. Elevated levels of HCys, known as hyperhomocysteinemia, have been associated with health risks, including cardiovascular and neurological disorders. This study examined the incidence of hyperhomocysteinemia in an unselected female population and evaluated the effectiveness of a Food for Special Medical Purposes (FSMPs), EUCIS PLUS, in reducing HCys levels.The study was divided into two phases: The first phase of the study, conducted at the Poliambulatorio Polimedica in Trebaseleghe (PD), evaluated the incidence of hyperhomocysteinemia in 181 women with an average age of 47.8 years; the second phase tested the effectiveness of EUCIS PLUS, a FSMPs, in reducing HCys levels in women with values above 10 µmol/L. During Phase 1, an incidence of hyperhomocysteinemia was observed in 81.2% of 181 women, with mean HCys levels of 15.4 µmol/L. Phase 2 involved treating 44 women with HCys >10 µmol/L using EUCIS PLUS, resulting in an average reduction of HCys levels by 36%, reaching 10.7 µmol/L after two months of treatment. Hyperomocysteinemia is an underdiagnosed risk condition. The results of this study highlight the importance of diagnosing and managing hyperhomocysteinemia and suggest that the FSMPs EUCIS PLUS can be an effective and well-tolerated therapeutic option.

同型半胱氨酸(HCys)是一种含硫氨基酸,参与蛋氨酸向半胱氨酸的转化。HCys水平升高,即高同型半胱氨酸血症,与健康风险有关,包括心血管和神经系统疾病。本研究调查了未选定女性人群中高同型半胱氨酸血症的发生率,并评估了特殊医疗用途食品(FSMPs) EUCIS PLUS在降低HCys水平方面的有效性。该研究分为两个阶段:第一阶段研究在Trebaseleghe (PD)的Poliambulatorio Polimedica进行,评估了181名平均年龄47.8岁的女性高同型半胱氨酸血症的发生率;第二阶段测试了EUCIS PLUS(一种FSMPs)在降低HCys水平高于10µmol/L的女性中的有效性。在第一阶段,181名女性中有81.2%的人出现高同型半胱氨酸血症,平均HCys水平为15.4µmol/L。第二阶段涉及使用EUCIS PLUS治疗44名HCys水平为10 μ mol/L的妇女,结果HCys水平平均降低36%,治疗两个月后达到10.7 μ mol/L。高半胱氨酸血症是一种未被诊断的危险状况。这项研究的结果强调了诊断和管理高同型半胱氨酸血症的重要性,并表明FSMPs EUCIS PLUS可能是一种有效且耐受性良好的治疗选择。
{"title":"Hyperomocysteinemia in an Unselected Female Population: Incidence and Treatment Options.","authors":"Francesca Manganello, Giuseppe Mungo, Donatella Rettore, Esther Otaño Ruiz, Antonio Frungillo","doi":"10.1089/jmf.2024.0214","DOIUrl":"10.1089/jmf.2024.0214","url":null,"abstract":"<p><p>Homocysteine (HCys) is a sulfur-containing amino acid involved in the conversion of methionine to cysteine. Elevated levels of HCys, known as hyperhomocysteinemia, have been associated with health risks, including cardiovascular and neurological disorders. This study examined the incidence of hyperhomocysteinemia in an unselected female population and evaluated the effectiveness of a Food for Special Medical Purposes (FSMPs), EUCIS PLUS, in reducing HCys levels.The study was divided into two phases: The first phase of the study, conducted at the Poliambulatorio Polimedica in Trebaseleghe (PD), evaluated the incidence of hyperhomocysteinemia in 181 women with an average age of 47.8 years; the second phase tested the effectiveness of EUCIS PLUS, a FSMPs, in reducing HCys levels in women with values above 10 µmol/L. During Phase 1, an incidence of hyperhomocysteinemia was observed in 81.2% of 181 women, with mean HCys levels of 15.4 µmol/L. Phase 2 involved treating 44 women with HCys >10 µmol/L using EUCIS PLUS, resulting in an average reduction of HCys levels by 36%, reaching 10.7 µmol/L after two months of treatment. Hyperomocysteinemia is an underdiagnosed risk condition. The results of this study highlight the importance of diagnosing and managing hyperhomocysteinemia and suggest that the FSMPs EUCIS PLUS can be an effective and well-tolerated therapeutic option.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"304-307"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aqueous Leaf Extract of Azadirachta indica Protects Against Gentamicin-Induced Kidney Injury via Decreases in Renal Function, Inflammation, and Apoptosis Markers. 印楝叶水提物通过降低肾功能、炎症和细胞凋亡标志物对庆大霉素所致肾损伤的保护作用。
IF 1.7 3区 农林科学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2025-03-01 Epub Date: 2025-01-13 DOI: 10.1089/jmf.2023.0294
Oluwadare J Ogundipe, Abodunrin A Ojetola, Omolola F Akinpelu, Ibukun T Sossou, Ayomide Babatunde Ishola

The effect of the aqueous extract of Azadirachta indica (AAI) on gentamicin (GEN)-induced kidney injury was investigated. The study involves 20 adult male Wistar rats (housed in four separate plastic cages) such that graded dosages of AAI were administered to the experimental group for 14 days per oral (PO) before exposure to GEN toxicity (100 mg/kg) for 1 week. At the end of the study, comparisons of some markers of renal functions, antioxidant status, and inflammatory and apoptotic markers were made between the control, GEN, and AAI-pretreated groups at P < .05. The result showed that GEN treatment caused a significant increase (P < .05) in body weight, kidney weight, urea, bilirubin, kidney injury molecule 1 (KIM 1), cystatin C, malondialdehyde (MDA), reduced glutathione (GSH), tumor necrotic factor alpha (TNF-α), interleukin-1 (IL-2), caspase-3, and B-cell lymphoma-2 associated X (BAX) as well as a significant decrease (P < .05) in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (Gpx), and B-cell lymphoma (BCL)-2 level. Pre-treatment with graded doses of AAI caused a significant increase in urea, CAT, and GPx as well as a significant decrease (P < .05) in kidney weight, bilirubin, KIM 1, cystatin C, MDA, GSH, SOD, TNF-α, IL-2, caspase-3, BAX, and BCL-2. There was an appreciable difference in the kidney histology of the AAI pre-treated groups compared with the GEN. Hence, the extract has prophylactic potential in managing GEN-induced nephrotoxicity by decreasing the markers of renal function and inflammation and downregulating the markers of apoptosis.

研究印楝水提物(AAI)对庆大霉素(GEN)所致大鼠肾损伤的影响。该研究涉及20只成年雄性Wistar大鼠(饲养在4个单独的塑料笼子中),实验组在暴露于GEN毒性(100 mg/kg) 1周之前,每次口服给药14天(PO)。研究结束时,比较对照组、GEN和aai预处理组肾脏功能、抗氧化状态、炎症和凋亡标志物的差异(P < 0.05)。结果表明,GEN处理导致大鼠体重、肾重、尿素、胆红素、肾损伤分子1 (KIM 1)、胱抑素C、丙二醛(MDA)、还原性谷胱甘肽(GSH)、肿瘤坏死因子α (TNF-α)、白细胞介素-1 (IL-2)、caspase-3和b细胞淋巴瘤-2相关X (BAX)显著升高(P < 0.05),超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(Gpx)和b细胞淋巴瘤(BCL)-2水平显著降低(P < 0.05)。分级剂量AAI预处理后,尿素、CAT、GPx显著升高,肾重、胆红素、KIM 1、胱抑素C、MDA、GSH、SOD、TNF-α、IL-2、caspase-3、BAX、BCL-2显著降低(P < 0.05)。与gen相比,AAI预处理组的肾脏组织学有明显差异,因此,AAI提取物通过降低肾功能和炎症标志物以及下调细胞凋亡标志物,具有预防gen诱导肾毒性的潜力。
{"title":"Aqueous Leaf Extract of <i>Azadirachta indica</i> Protects Against Gentamicin-Induced Kidney Injury via Decreases in Renal Function, Inflammation, and Apoptosis Markers.","authors":"Oluwadare J Ogundipe, Abodunrin A Ojetola, Omolola F Akinpelu, Ibukun T Sossou, Ayomide Babatunde Ishola","doi":"10.1089/jmf.2023.0294","DOIUrl":"10.1089/jmf.2023.0294","url":null,"abstract":"<p><p>The effect of the aqueous extract of <i>Azadirachta indica</i> (AAI) on gentamicin (GEN)-induced kidney injury was investigated. The study involves 20 adult male Wistar rats (housed in four separate plastic cages) such that graded dosages of AAI were administered to the experimental group for 14 days per oral (PO) before exposure to GEN toxicity (100 mg/kg) for 1 week. At the end of the study, comparisons of some markers of renal functions, antioxidant status, and inflammatory and apoptotic markers were made between the control, GEN, and AAI-pretreated groups at <i>P</i> < .05. The result showed that GEN treatment caused a significant increase (<i>P</i> < .05) in body weight, kidney weight, urea, bilirubin, kidney injury molecule 1 (KIM 1), cystatin C, malondialdehyde (MDA), reduced glutathione (GSH), tumor necrotic factor alpha (TNF-<i>α</i>), interleukin-1 (IL-2), caspase-3, and B-cell lymphoma-2 associated X (BAX) as well as a significant decrease (<i>P</i> < .05) in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (Gpx), and B-cell lymphoma (BCL)-2 level. Pre-treatment with graded doses of AAI caused a significant increase in urea, CAT, and GPx as well as a significant decrease (<i>P</i> < .05) in kidney weight, bilirubin, KIM 1, cystatin C, MDA, GSH, SOD, TNF-<i>α</i>, IL-2, caspase-3, BAX, and BCL-2. There was an appreciable difference in the kidney histology of the AAI pre-treated groups compared with the GEN. Hence, the extract has prophylactic potential in managing GEN-induced nephrotoxicity by decreasing the markers of renal function and inflammation and downregulating the markers of apoptosis.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"272-280"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Effects of a Calming Herbal Tea Blend on Perioperative Anxiety: A Randomized Clinical Trial. 探索镇静草药茶对围术期焦虑的影响:随机临床试验
IF 1.7 3区 农林科学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2025-03-01 Epub Date: 2024-11-08 DOI: 10.1089/jmf.2024.0170
Victória Cosel Zampieri, Itamar Luís Gonçalves, Ana Luiza Lira, Jamile Zeni, Geciane Toniazzo Backes, André Keng Wei Hsu

This research aimed to explore the effectiveness of consuming a calming herbal tea blend, comprising Matricaria recutita, Passiflora incarnata L., and Pimpinella anisum L., in comparison to a placebo tea infused with lemon, to ascertain whether the herbal blend possesses anxiety-reducing properties capable of alleviating perioperative anxiety. The study adopted a clinical randomized, double-blind design and collected data from volunteers undergoing elective surgery at Hospital Unimed Erechim in the northern region of Rio Grande do Sul, Brazil. A total of 210 participants were enrolled and randomly allocated into two groups: one receiving the placebo tea and the other the sedative herbal tea. All participants completed a questionnaire postoperatively to assess anxiety levels, employing the adapted Portuguese version of the DASS-21 Scale (Depression, Anxiety, and Stress Scale). Results revealed no significant difference in anxiety levels between the group consuming the calming herbal tea and the group consuming the placebo tea. However, consumption of the anxiolytic herbal tea was associated with a notable increase in positive sentiments toward the surgical procedure (P = .0009). Furthermore, the study demonstrated that the DASS-21 questionnaire exhibited a preoperative profile comparable to the clinical scenarios depicted by the scale. Both the calming herbal tea and the placebo tea were found to effectively mitigate perioperative anxiety. This suggests that both options-soothing herbal tea and placebo tea-can be considered safe, efficacious, and pleasant methods for reducing preoperative fasting requirements.

本研究旨在探讨饮用由洋甘菊、西番莲和茴芹组成的镇静草药混合茶与饮用浸泡柠檬的安慰剂茶的效果,以确定草药混合茶是否具有减轻围手术期焦虑的特性。该研究采用临床随机双盲设计,从巴西南里奥格兰德州北部地区的 Unimed Erechim 医院接受择期手术的志愿者中收集数据。共有 210 人参加了这项研究,并被随机分配到两组:一组接受安慰剂茶,另一组接受镇静草药茶。所有参与者都在术后填写了一份问卷,以评估焦虑水平,问卷采用了改编的葡萄牙语版 DASS-21 量表(抑郁、焦虑和压力量表)。结果显示,饮用镇静草药茶的组别与饮用安慰剂茶的组别在焦虑水平上没有明显差异。不过,饮用抗焦虑草药茶后,患者对手术过程的积极情绪明显增加(P = 0.0009)。此外,研究表明 DASS-21 问卷显示的术前情况与量表所描述的临床情景相当。研究发现,安神草药茶和安慰剂茶都能有效缓解围手术期焦虑。这表明,舒缓花草茶和安慰剂茶这两种选择都可被视为安全、有效和令人愉悦的减少术前禁食要求的方法。
{"title":"Exploring the Effects of a Calming Herbal Tea Blend on Perioperative Anxiety: A Randomized Clinical Trial.","authors":"Victória Cosel Zampieri, Itamar Luís Gonçalves, Ana Luiza Lira, Jamile Zeni, Geciane Toniazzo Backes, André Keng Wei Hsu","doi":"10.1089/jmf.2024.0170","DOIUrl":"10.1089/jmf.2024.0170","url":null,"abstract":"<p><p>This research aimed to explore the effectiveness of consuming a calming herbal tea blend, comprising <i>Matricaria recutita, Passiflora incarnata L</i>., and <i>Pimpinella anisum L</i>., in comparison to a placebo tea infused with lemon, to ascertain whether the herbal blend possesses anxiety-reducing properties capable of alleviating perioperative anxiety. The study adopted a clinical randomized, double-blind design and collected data from volunteers undergoing elective surgery at Hospital Unimed Erechim in the northern region of Rio Grande do Sul, Brazil. A total of 210 participants were enrolled and randomly allocated into two groups: one receiving the placebo tea and the other the sedative herbal tea. All participants completed a questionnaire postoperatively to assess anxiety levels, employing the adapted Portuguese version of the DASS-21 Scale (Depression, Anxiety, and Stress Scale). Results revealed no significant difference in anxiety levels between the group consuming the calming herbal tea and the group consuming the placebo tea. However, consumption of the anxiolytic herbal tea was associated with a notable increase in positive sentiments toward the surgical procedure (<i>P</i> = .0009). Furthermore, the study demonstrated that the DASS-21 questionnaire exhibited a preoperative profile comparable to the clinical scenarios depicted by the scale. Both the calming herbal tea and the placebo tea were found to effectively mitigate perioperative anxiety. This suggests that both options-soothing herbal tea and placebo tea-can be considered safe, efficacious, and pleasant methods for reducing preoperative fasting requirements.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"266-271"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cinnamon (Cinnamomum zeylanicum) Aqueous Extract Regulates the Parameters of Metabolic Syndrome in a Model of Wistar Rats with a Diet High in Fat and Fructose. 肉桂(Cinnamomum zeylanicum)水提物对高脂高果糖Wistar大鼠代谢综合征模型的调节作用
IF 1.7 3区 农林科学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2025-03-01 Epub Date: 2024-12-18 DOI: 10.1089/jmf.2024.0227
Gabriela Portillo-Rentería, Mario Del Toro-Equihua, Karmina Sánchez-Meza, Mónica Ríos-Silva, Julio-Alcaraz Siqueiros, Javier Uribarren, Yolitzy Cárdenas

To identify the effect of Cinnamomum zeylanicum (CZ) aqueous extract on glucose, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure in male Wistar rats, fed with a high-fat and high-fructose diet (HFFD). Twenty-four male Wistar rats were randomized into four groups: Healthy (fed with standard diet), Healthy + CZ (fed with standard diet + CZ extract), HFFD (fed with HFFD), HFFD+CZ, (fed with HFFD + CZ extract). The CZ aqueous extract was administered 100 mg/kg/day by oral gavage to each rat for 8 weeks. Blood samples, blood pressure, and weight were taken at the beginning and end of the experiment. The rats were euthanized after the experiment, according to the Mexican Official Standard NOM-062-ZOOO-1999. The administration of CZ aqueous extract significantly decreased glucose levels (F[1,18]=46.458, P < .001). The interaction between the type of diet and the extract had an effect on triglycerides (F[1,18]=14.93, P = .001), and systolic (F[1,18]=127, P < .001) and diastolic blood pressure levels (F[1,18]=146.13, P < .001) in male Wistar rats. HFFD, plus the administration of CZ aqueous extract over 8 weeks, significantly improved glucose, triglyceride, and systolic and diastolic blood pressure levels, regulating metabolic parameters in male Wistar rats.

研究肉桂水提取物对以高脂高果糖饮食(HFFD)喂养的雄性 Wistar 大鼠血糖、甘油三酯、高密度脂蛋白胆固醇和血压的影响。24 只雄性 Wistar 大鼠被随机分为四组:健康组(以标准饮食喂养)、健康 + CZ 组(以标准饮食 + CZ 提取物喂养)、HFFD 组(以 HFFD 喂养)、HFFD+CZ 组(以 HFFD + CZ 提取物喂养)。每只大鼠每天口服 100 毫克/千克 CZ 水提取物,连续灌胃 8 周。在实验开始和结束时采集大鼠的血样、血压和体重。实验结束后,根据墨西哥官方标准 NOM-062-ZOOO-1999 对大鼠实施安乐死。服用 CZ 水提取物可显著降低血糖水平(F[1,18]=46.458,P < .001)。饮食类型与提取物之间的相互作用对雄性 Wistar 大鼠的甘油三酯(F[1,18]=14.93,P = .001)、收缩压(F[1,18]=127,P < .001)和舒张压水平(F[1,18]=146.13,P < .001)有影响。HFFD 加上服用 CZ 水提取物 8 周,可显著改善雄性 Wistar 大鼠的血糖、甘油三酯、收缩压和舒张压水平,调节代谢参数。
{"title":"Cinnamon (<i>Cinnamomum zeylanicum</i>) Aqueous Extract Regulates the Parameters of Metabolic Syndrome in a Model of Wistar Rats with a Diet High in Fat and Fructose.","authors":"Gabriela Portillo-Rentería, Mario Del Toro-Equihua, Karmina Sánchez-Meza, Mónica Ríos-Silva, Julio-Alcaraz Siqueiros, Javier Uribarren, Yolitzy Cárdenas","doi":"10.1089/jmf.2024.0227","DOIUrl":"10.1089/jmf.2024.0227","url":null,"abstract":"<p><p>To identify the effect of <i>Cinnamomum zeylanicum</i> (CZ) aqueous extract on glucose, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure in male Wistar rats, fed with a high-fat and high-fructose diet (HFFD). Twenty-four male Wistar rats were randomized into four groups: Healthy (fed with standard diet), Healthy + CZ (fed with standard diet + CZ extract), HFFD (fed with HFFD), HFFD+CZ, (fed with HFFD + CZ extract). The CZ aqueous extract was administered 100 mg/kg/day by oral gavage to each rat for 8 weeks. Blood samples, blood pressure, and weight were taken at the beginning and end of the experiment. The rats were euthanized after the experiment, according to the Mexican Official Standard NOM-062-ZOOO-1999. The administration of CZ aqueous extract significantly decreased glucose levels (F[1,18]=46.458, <i>P</i> < .001). The interaction between the type of diet and the extract had an effect on triglycerides (F[1,18]=14.93, <i>P</i> = .001), and systolic (F[1,18]=127, <i>P</i> < .001) and diastolic blood pressure levels (F[1,18]=146.13, <i>P</i> < .001) in male Wistar rats. HFFD, plus the administration of CZ aqueous extract over 8 weeks, significantly improved glucose, triglyceride, and systolic and diastolic blood pressure levels, regulating metabolic parameters in male Wistar rats.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"299-303"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of medicinal food
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1