Pub Date : 2017-06-03DOI: 10.4172/2167-0943.1000227
D. Lu, Tingren Lu, Yi Lu, Sha Cao
Human suicide is affected by a great variety of causality. Due to diversities of suicide causalities, suicide predictions and prevention are no easy tasks. This article outlines the history of suicide study, current diagnostic and therapeutic routine, pathogenesis study, new therapeutic models and future directions. This introduction aims to update human suicide study and future aspects of clinical interventions in suicide risk predictions and prevention.
{"title":"Introduction for Suicide Study","authors":"D. Lu, Tingren Lu, Yi Lu, Sha Cao","doi":"10.4172/2167-0943.1000227","DOIUrl":"https://doi.org/10.4172/2167-0943.1000227","url":null,"abstract":"Human suicide is affected by a great variety of causality. Due to diversities of suicide causalities, suicide predictions and prevention are no easy tasks. This article outlines the history of suicide study, current diagnostic and therapeutic routine, pathogenesis study, new therapeutic models and future directions. This introduction aims to update human suicide study and future aspects of clinical interventions in suicide risk predictions and prevention.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"37 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76146880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-24DOI: 10.4172/2167-0943.1000226
H. Jelinek, D. Cornforth, M. Tarvainen, I. Spence, J. Russell
Objective: The objective was to determine changes in heart rate variability (HRV) in response to orthostatic challenge in a convenience sample of patients with anorexia nervosa compared to age-matched controls. A decrease in HRV has been shown to correlate with an increased risk of heart attack in coronary artery disease and heart failure patients. Method: Clinical data and ECG recordings were collected from 37 patients with eating disorders of which 16 had a diagnosis of anorexia nervosa and 42 controls. HRV was analyzed using linear and nonlinear methods during rest and orthostatic challenge from sitting to standing. Results: Significant sympathovagal changes were identified in the anorexia nervosa group, especially with nonlinear HRV parameters and orthostatic challenge. Sample entropy, a nonlinear measure provided the best discrimination between the two groups on standing (1.58 ± 0.42 vs. 1.19 ± 0.4; p<0.0001) and when the change in HRV was measured from sitting to standing (-0.06 ± 0.36 vs. -0.42 ± 0.34; p<0.0001). The anorexia nervosa group had a significantly larger response to orthostatic challenge compared to the control group suggesting sympathetic dysfunction. Discussion: Including nonlinear measures and orthostatic challenge from an ECG recording of anorexia nervosa patients at initial clinical assessment on admission to hospital provides a noninvasive, sensitive tool to determine loss of normal physiological autonomic control of heart rate that may be related to an increased risk of arrhythmic events that requires further monitoring. Conclusion: Nonlinear HRV measures are more sensitive in identifying sympathetic and parasympathetic changes associated with orthostatic challenge in patients with anorexia nervosa.
目的:目的是确定在一个方便的神经性厌食症患者样本中，与年龄匹配的对照组相比，心率变异性(HRV)对直立性挑战的响应变化。HRV的降低已被证明与冠状动脉疾病和心力衰竭患者心脏病发作风险的增加有关。方法:收集37例进食障碍患者的临床资料和心电图记录，其中神经性厌食症16例，对照组42例。采用线性和非线性方法分析休息和从坐到站的直立性挑战时的心率变异。结果:神经性厌食症组交感迷走神经明显改变，尤其是非线性HRV参数和直立性挑战。样本熵是一种非线性度量，在两组站立时提供了最好的区分(1.58±0.42 vs. 1.19±0.4;p<0.0001)，当测量HRV从坐姿到站立时的变化(-0.06±0.36 vs -0.42±0.34;p < 0.0001)。与对照组相比，神经性厌食症组对直立挑战的反应明显更大，提示交感神经功能障碍。讨论:将神经性厌食症患者的心电图记录的非线性测量和直立性挑战纳入入院的初步临床评估，提供了一种无创的、灵敏的工具来确定正常的生理自主心率控制的丧失，这可能与心律失常事件的风险增加有关，需要进一步监测。结论:非线性HRV测量在识别神经性厌食症患者与直立挑战相关的交感和副交感神经变化方面更为敏感。
{"title":"Decreased Sample Entropy to Orthostatic Challenge in Anorexia Nervosa","authors":"H. Jelinek, D. Cornforth, M. Tarvainen, I. Spence, J. Russell","doi":"10.4172/2167-0943.1000226","DOIUrl":"https://doi.org/10.4172/2167-0943.1000226","url":null,"abstract":"Objective: The objective was to determine changes in heart rate variability (HRV) in response to orthostatic \u0000 challenge in a convenience sample of patients with anorexia nervosa compared to age-matched controls. A \u0000 decrease in HRV has been shown to correlate with an increased risk of heart attack in coronary artery disease and \u0000 heart failure patients. \u0000Method: Clinical data and ECG recordings were collected from 37 patients with eating disorders of which 16 had \u0000 a diagnosis of anorexia nervosa and 42 controls. HRV was analyzed using linear and nonlinear methods during rest \u0000 and orthostatic challenge from sitting to standing. \u0000Results: Significant sympathovagal changes were identified in the anorexia nervosa group, especially with \u0000 nonlinear HRV parameters and orthostatic challenge. Sample entropy, a nonlinear measure provided the best \u0000 discrimination between the two groups on standing (1.58 ± 0.42 vs. 1.19 ± 0.4; p<0.0001) and when the change in \u0000 HRV was measured from sitting to standing (-0.06 ± 0.36 vs. -0.42 ± 0.34; p<0.0001). The anorexia nervosa group \u0000 had a significantly larger response to orthostatic challenge compared to the control group suggesting sympathetic \u0000 dysfunction. Discussion: Including nonlinear measures and orthostatic challenge from an ECG recording of anorexia \u0000 nervosa patients at initial clinical assessment on admission to hospital provides a noninvasive, sensitive tool to \u0000 determine loss of normal physiological autonomic control of heart rate that may be related to an increased risk of \u0000 arrhythmic events that requires further monitoring. \u0000Conclusion: Nonlinear HRV measures are more sensitive in identifying sympathetic and parasympathetic changes associated with orthostatic challenge in patients with anorexia nervosa.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"80 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82305097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-15DOI: 10.4172/2167-0943.1000225
H. Ueshiba
Low levels of testosterone are related with metabolic syndrome and type 2 diabetes mellitus. Testosterone levels are considered to be negatively correlated with insulin resistance and HbA1c levels. There are also reports that testosterone replacement therapy reduces insulin resistance or improves glycemic control. Transdermal administration of testosterone ointment (Glowmin) is a method of drug administration that keeps blood concentrations stable and constant. In this study, testosterone ointment (Glowmin) was administrated as a testosterone supplement to male metabolic syndrome with low free testosterone levels. This study included 5 male metabolic syndrome with low free testosterone levels (mean age, 50.6 ± 8.8 years; mean BMI, 29.5 ± 3.1 kg/m2; mean waist circumference, 97 ± 7 cm; free testosterone levels, <8.5 pg/ml; values indicate means ± SD). Glowmin was administrated to the submandibular area at a dose of 0.3 g twice a day for 6 months. Three months after administration, a significant decrease was observed in fasting immunoreactive insulin levels, homeostasis model assessment for insulin resistance, total cholesterol and LDL-C. Six-months after administration, each of these parameter estimates remained steady. In conclusion, transdermal administration of testosterone ointment (Glowmin) gradually reduced insulin resistance in male metabolic syndrome with low free testosterone levels.
{"title":"The Efficacy of Testosterone Ointment on Insulin Resistance in Men withMetabolic Syndrome","authors":"H. Ueshiba","doi":"10.4172/2167-0943.1000225","DOIUrl":"https://doi.org/10.4172/2167-0943.1000225","url":null,"abstract":"Low levels of testosterone are related with metabolic syndrome and type 2 diabetes mellitus. Testosterone levels \u0000 are considered to be negatively correlated with insulin resistance and HbA1c levels. There are also reports that \u0000 testosterone replacement therapy reduces insulin resistance or improves glycemic control. \u0000Transdermal administration of testosterone ointment (Glowmin) is a method of drug administration that keeps \u0000 blood concentrations stable and constant. In this study, testosterone ointment (Glowmin) was administrated as a \u0000 testosterone supplement to male metabolic syndrome with low free testosterone levels. This study included 5 male \u0000 metabolic syndrome with low free testosterone levels (mean age, 50.6 ± 8.8 years; mean BMI, 29.5 ± 3.1 kg/m2; \u0000 mean waist circumference, 97 ± 7 cm; free testosterone levels, <8.5 pg/ml; values indicate means ± SD). Glowmin \u0000 was administrated to the submandibular area at a dose of 0.3 g twice a day for 6 months. Three months after \u0000 administration, a significant decrease was observed in fasting immunoreactive insulin levels, homeostasis model \u0000 assessment for insulin resistance, total cholesterol and LDL-C. Six-months after administration, each of these \u0000 parameter estimates remained steady. \u0000In conclusion, transdermal administration of testosterone ointment (Glowmin) gradually reduced insulin resistance \u0000 in male metabolic syndrome with low free testosterone levels.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"30 4","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72571855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-03DOI: 10.4172/2167-0943.1000224
J. Kobayashi, K. Ikeda
Diagnostic criteria for metabolic syndrome in Japan are different from other countries. In this paper, we outline the diagnostic criteria and problems that the authors consider these criteria to have, as well as explain content to be changed in 2018.
{"title":"Diagnostic Criteria and Future Trends of Metabolic Syndrome in Japan","authors":"J. Kobayashi, K. Ikeda","doi":"10.4172/2167-0943.1000224","DOIUrl":"https://doi.org/10.4172/2167-0943.1000224","url":null,"abstract":"Diagnostic criteria for metabolic syndrome in Japan are different from other countries. In this paper, we outline the diagnostic criteria and problems that the authors consider these criteria to have, as well as explain content to be changed in 2018.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"17 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84503941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-31DOI: 10.4172/2167-0943.1000222
S. Dzugkoev, Mozhaeva, O. I. Margieva, A. Tedtoeva, F. Dzugkoeva
The aim of the study was to elucidate the state of lipid metabolism, the processes of lipid peroxidation (LPO) and the state of the antioxidant system (AOS) in pregnant women with metabolic syndrome. A comprehensive examination of pregnant women without pathology was performed, with signs of a metabolic syndrome. Analysis of the data showed that in pregnant women with impaired glucose metabolism, activation of LPO processes takes place against the background of a decrease in the activity of AOS enzymes. Active metabolites of oxygen (AMC) and LPO products lead to a decrease in the NO content of the main vasodilating factor. As a result of these disorders, hypoxia develops, which significantly affects the formation of the fetus. The data obtained make it possible to recommend the determination of the parameters of the POL-AOS system and the NO-forming endothelial function as additional laboratory tests in pregnant women with metabolic syndrome (MS).
{"title":"Biochemical Markers of Metabolic Syndrome in Pregnant Women","authors":"S. Dzugkoev, Mozhaeva, O. I. Margieva, A. Tedtoeva, F. Dzugkoeva","doi":"10.4172/2167-0943.1000222","DOIUrl":"https://doi.org/10.4172/2167-0943.1000222","url":null,"abstract":"The aim of the study was to elucidate the state of lipid metabolism, the processes of lipid peroxidation (LPO) and the state of the antioxidant system (AOS) in pregnant women with metabolic syndrome. A comprehensive examination of pregnant women without pathology was performed, with signs of a metabolic syndrome. Analysis of the data showed that in pregnant women with impaired glucose metabolism, activation of LPO processes takes place against the background of a decrease in the activity of AOS enzymes. Active metabolites of oxygen (AMC) and LPO products lead to a decrease in the NO content of the main vasodilating factor. As a result of these disorders, hypoxia develops, which significantly affects the formation of the fetus. The data obtained make it possible to recommend the determination of the parameters of the POL-AOS system and the NO-forming endothelial function as additional laboratory tests in pregnant women with metabolic syndrome (MS).","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"35 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89905599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-31DOI: 10.4172/2167-0943.1000E120
G. Colussi, G. Soardo, Valentina Fagotto, L. Sechi
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent hepatic problem in Western and Asian countries where it can affect more than 30% of people [1]. NAFLD pathological characteristic is a fat infiltration of the hepatocytes (hepatic steatosis) in subjects who are mild or no alcohol drinkers and do not have other secondary causes of hepatic lipid accumulation. In one fifth of affected patients, NAFLD can evolve in a liver inflammatory damage, which is associated with oxidative stress, cytolysis, and fibrosis (steatohepatitis) [2]. Of these patients, more than one-third progress to liver cirrhosis and a small part can develop hepatocarcinoma along years. It’s not clear why some patients with NAFLD evolve to non-alcoholic steatohepatitis (NASH) while others remain stable over years, though a role of intestinal inflammation, gut dysbiosis, and hypovitaminosis D has been recently proposed [3]. Consistently, subjects at high risk to develop NAFLD are those affected by obesity, type 2 diabetes mellitus, and other conditions associated with insulin resistance or hyperinsulinemia such as hypertension, dyslipidemia, polycystic ovary disease, and metabolic syndrome, as well as patients with chronic inflammatory bowel diseases [4]. Patients with NAFLD are characterized by increased circulatory levels of triglycerides and free fatty acids (FFAs) that come from the adipose tissue through the lipolytic process, from the hepatic lipid de-novo synthesis, and to a minor extent from food intake. Both insulin resistance and hyperinsulinemia in predisposed subjects are associated with a visceral fat distribution and are responsible for the high level of circulatory FFAs [5]. FFAs enter and accumulate in insulin-resistant hepatocytes and by esterification with glycerol increase hepatic triglycerides synthesis and very low-density lipoproteins (VLDL) production; thus, favoring hypertriglyceridemia. The overflow of plasma lipids and lipid metabolites in non-adipose tissues induces “lipotoxicity”, a pathological process characterized by lipids accumulation in liver and in other organs such as heart, kidney, pancreas, and skeletal muscle [6]. This process is responsible for the development and progression of heart and kidney failure, obesity, and diabetes, as well as for the systemic release of inflammatory cytokines. System cytokines maintain chronic subclinical inflammation, induce oxidative stress and endothelial dysfunction, and predispose to the atherosclerotic process [7]. Although NAFLD has been considered as the hepatic manifestation of the metabolic syndrome, evidence has shown that NAFLD is associated with cardiovascular morbidity and mortality independently of metabolic syndrome. Therefore, other than pro-cirrhotic, NAFLD had to be considered an important modifiable risk factor for cardiovascular diseases [8].
{"title":"Omega-3 Polyunsaturated Fatty Acids in the Treatment of Non-Alcoholic FattyLiver Disease: Are They So Good?","authors":"G. Colussi, G. Soardo, Valentina Fagotto, L. Sechi","doi":"10.4172/2167-0943.1000E120","DOIUrl":"https://doi.org/10.4172/2167-0943.1000E120","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is the most prevalent hepatic problem in Western and Asian countries where it can affect more than 30% of people [1]. NAFLD pathological characteristic is a fat infiltration of the hepatocytes (hepatic steatosis) in subjects who are mild or no alcohol drinkers and do not have other secondary causes of hepatic lipid accumulation. In one fifth of affected patients, NAFLD can evolve in a liver inflammatory damage, which is associated with oxidative stress, cytolysis, and fibrosis (steatohepatitis) [2]. Of these patients, more than one-third progress to liver cirrhosis and a small part can develop hepatocarcinoma along years. It’s not clear why some patients with NAFLD evolve to non-alcoholic steatohepatitis (NASH) while others remain stable over years, though a role of intestinal inflammation, gut dysbiosis, and hypovitaminosis D has been recently proposed [3]. Consistently, subjects at high risk to develop NAFLD are those affected by obesity, type 2 diabetes mellitus, and other conditions associated with insulin resistance or hyperinsulinemia such as hypertension, dyslipidemia, polycystic ovary disease, and metabolic syndrome, as well as patients with chronic inflammatory bowel diseases [4]. Patients with NAFLD are characterized by increased circulatory levels of triglycerides and free fatty acids (FFAs) that come from the adipose tissue through the lipolytic process, from the hepatic lipid de-novo synthesis, and to a minor extent from food intake. Both insulin resistance and hyperinsulinemia in predisposed subjects are associated with a visceral fat distribution and are responsible for the high level of circulatory FFAs [5]. FFAs enter and accumulate in insulin-resistant hepatocytes and by esterification with glycerol increase hepatic triglycerides synthesis and very low-density lipoproteins (VLDL) production; thus, favoring hypertriglyceridemia. The overflow of plasma lipids and lipid metabolites in non-adipose tissues induces “lipotoxicity”, a pathological process characterized by lipids accumulation in liver and in other organs such as heart, kidney, pancreas, and skeletal muscle [6]. This process is responsible for the development and progression of heart and kidney failure, obesity, and diabetes, as well as for the systemic release of inflammatory cytokines. System cytokines maintain chronic subclinical inflammation, induce oxidative stress and endothelial dysfunction, and predispose to the atherosclerotic process [7]. Although NAFLD has been considered as the hepatic manifestation of the metabolic syndrome, evidence has shown that NAFLD is associated with cardiovascular morbidity and mortality independently of metabolic syndrome. Therefore, other than pro-cirrhotic, NAFLD had to be considered an important modifiable risk factor for cardiovascular diseases [8].","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"17 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78921109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-08DOI: 10.4172/2167-0943.1000221
M. White, Traci D. Jarrett, C. Komar
Metabolic syndrome refers to a group of risk factors that increase a person’s chance of developing cardiovascular disease and/or diabetes mellitus type II. Hypertension and insulin resistance, two factors associated with metabolic syndrome, are reflective of prenatal androgen exposure. Androgen exposure in utero is also related to the ratio of the length of the 2nd and 4th digits of the hand (2D:4D). Objective: To test the hypothesis that the 2D:4D correlates with parameters associated with metabolic syndrome measuring in the risk range for developing metabolic disease. If our hypothesis is correct, measuring a patient’s 2D: 4D would be a non-invasive way to determine the risk for developing cardiovascular disease and/or diabetes mellitus type II. Methods: The 2D:4Ds of 45 adults were measured at a health fair and correlated with the parameters associated with metabolic syndrome, and body mass index (BMI). The predictability of the 2D:4D for determining the risk of metabolic disease was also assessed. Results: Significant correlations were found between the 2D:4D of the left and right hands with elevated concentrations of circulating triglycerides, and the right hand with BMI. The AUC for the relationship of the right and left hand 2D:4D with elevated triglycerides was 0.7538 and 0.7012, respectively. Conclusion: The relationship between the 2D:4D and elevated triglycerides supports use of the 2D:4D as a noninvasive screening tool to assess an individual’s risk for metabolic syndrome. Such a screening tool may increase the number of people willing to participate, enabling earlier detection and intervention to stave off metabolic diseases.
{"title":"Correlation between Digit Length Ratios and Risk Factors Associated withMetabolic Syndrome","authors":"M. White, Traci D. Jarrett, C. Komar","doi":"10.4172/2167-0943.1000221","DOIUrl":"https://doi.org/10.4172/2167-0943.1000221","url":null,"abstract":"Metabolic syndrome refers to a group of risk factors that increase a person’s chance of developing cardiovascular \u0000 disease and/or diabetes mellitus type II. Hypertension and insulin resistance, two factors associated with metabolic \u0000 syndrome, are reflective of prenatal androgen exposure. Androgen exposure in utero is also related to the ratio of \u0000 the length of the 2nd and 4th digits of the hand (2D:4D). \u0000 Objective: To test the hypothesis that the 2D:4D correlates with parameters associated with metabolic syndrome \u0000 measuring in the risk range for developing metabolic disease. If our hypothesis is correct, measuring a patient’s 2D: \u0000 4D would be a non-invasive way to determine the risk for developing cardiovascular disease and/or diabetes mellitus \u0000 type II. Methods: The 2D:4Ds of 45 adults were measured at a health fair and correlated with the parameters associated \u0000 with metabolic syndrome, and body mass index (BMI). The predictability of the 2D:4D for determining the risk of \u0000 metabolic disease was also assessed. Results: Significant correlations were found between the 2D:4D of the left and right hands with elevated \u0000 concentrations of circulating triglycerides, and the right hand with BMI. The AUC for the relationship of the right and \u0000 left hand 2D:4D with elevated triglycerides was 0.7538 and 0.7012, respectively. Conclusion: The relationship between the 2D:4D and elevated triglycerides supports use of the 2D:4D as a noninvasive \u0000 screening tool to assess an individual’s risk for metabolic syndrome. Such a screening tool may increase \u0000 the number of people willing to participate, enabling earlier detection and intervention to stave off metabolic \u0000 diseases.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73620913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-30DOI: 10.4172/2167-0943.1000220
Xuekui Liu, Jun Liang, Q. Qiu, Fei Teng, Yu Wang, Yan Zhu, Y. Pei, Yuting Sun
Non-alcoholic fatty liver disease (NAFLD) is recognized as a major cause of liver-related morbidity and mortality. The aim of this study was to examine the longitudinal association between baseline hematocrit (HCT) level and the development of NAFLD in Chinese adults. We performed a prospective cohort study of 2798 healthy Chinese adults without NAFLD at baseline. A Cox proportional hazards model was used to determine hazard ratios for NAFLD incidence in two groups determined by baseline hematocrit levels (group A, HCT <49%; group B, HCT ≥ 49%). During 10346.5 person-years of follow-up, 474 (16.9%) NAFLD cases developed between 2008 and 2012. After adjusting for multiple covariates and change in the covariates during the follow-up period, the hazard ratios (95% confidence interval) for NAFLD incidence when comparing group B with group A were 1.17 (1.03-1.31) and 1.70 (1.26-2.31), respectively (p<0.001). Conclusions: HCT level may be a predictor of the development of NAFLD in Chinese adults.
{"title":"Association between Hematocrit Level and the Development of Non-Alcoholic Fatty Liver Disease in Chinese Adults: A 5-Year Study","authors":"Xuekui Liu, Jun Liang, Q. Qiu, Fei Teng, Yu Wang, Yan Zhu, Y. Pei, Yuting Sun","doi":"10.4172/2167-0943.1000220","DOIUrl":"https://doi.org/10.4172/2167-0943.1000220","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is recognized as a major cause of liver-related morbidity and mortality. \u0000 The aim of this study was to examine the longitudinal association between baseline hematocrit (HCT) level and the \u0000 development of NAFLD in Chinese adults. We performed a prospective cohort study of 2798 healthy Chinese adults \u0000 without NAFLD at baseline. A Cox proportional hazards model was used to determine hazard ratios for NAFLD incidence \u0000 in two groups determined by baseline hematocrit levels (group A, HCT <49%; group B, HCT ≥ 49%). During 10346.5 \u0000 person-years of follow-up, 474 (16.9%) NAFLD cases developed between 2008 and 2012. After adjusting for multiple \u0000 covariates and change in the covariates during the follow-up period, the hazard ratios (95% confidence interval) for \u0000 NAFLD incidence when comparing group B with group A were 1.17 (1.03-1.31) and 1.70 (1.26-2.31), respectively \u0000 (p<0.001). \u0000 Conclusions: HCT level may be a predictor of the development of NAFLD in Chinese adults.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80421338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-17DOI: 10.4172/2167-0943.1000219
E. Jean-Baptiste, P. Larco, Rodolphe Paul, Bello S. Jerome, N. C. Larco, R. Charles, J. V. Oettingen
Unpublished data collected by clinicians in Haiti have suggested that prevalence of coronary heart disease (CHD) among Haitian adults with diabetes may be low despite a high prevalence of cerebrovascular events. To our knowledge, no epidemiologic study has been performed to confirm this. We evaluated the necessity to conduct a prospective study on the cardiovascular outcomes in this population by crosssectionally examining cardiovascular risk factors in Haitian adults aged 30-74 years with newly diagnosed diabetes. Our aim was to determine whether their baseline characteristics supported the assertion of low CHD prevalence, and estimate the 10-year absolute cardiovascular disease (CVD) risk of these patients.
{"title":"High Cardiovascular Risk Profile in Adult Patients with Newly Diagnosed Diabetes in Haiti","authors":"E. Jean-Baptiste, P. Larco, Rodolphe Paul, Bello S. Jerome, N. C. Larco, R. Charles, J. V. Oettingen","doi":"10.4172/2167-0943.1000219","DOIUrl":"https://doi.org/10.4172/2167-0943.1000219","url":null,"abstract":"Unpublished data collected by clinicians in Haiti have suggested that prevalence of coronary heart disease (CHD) among Haitian adults with diabetes may be low despite a high prevalence of cerebrovascular events. To our knowledge, no epidemiologic study has been performed to confirm this. We evaluated the necessity to conduct a prospective study on the cardiovascular outcomes in this population by crosssectionally examining cardiovascular risk factors in Haitian adults aged 30-74 years with newly diagnosed diabetes. Our aim was to determine whether their baseline characteristics supported the assertion of low CHD prevalence, and estimate the 10-year absolute cardiovascular disease (CVD) risk of these patients.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78252618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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