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Journal of Neuro-Ophthalmology最新文献

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Acute Retinal Necrosis due to Varicella Zoster Virus Presenting Initially as Central Retinal Artery Occlusion and Posterior Ischemic Optic Neuropathy. 水痘带状疱疹病毒导致的急性视网膜坏死,最初表现为视网膜中央动脉闭塞和后部缺血性视神经病变。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-09-01 Epub Date: 2023-09-01 DOI: 10.1097/WNO.0000000000001964
Allan Q Phan, Jacob M Hands, Shaweta Khosa, Shri K Mishra
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引用次数: 0
Isolated Third Nerve Palsy as Presenting Symptom in Multiple Sclerosis Relapse. 多发性硬化症复发时出现的孤立第三神经麻痹症状
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-09-01 Epub Date: 2023-07-10 DOI: 10.1097/WNO.0000000000001936
Ricky Paramo, Lakshmi Leishangthem
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引用次数: 0
A Rare Case of Horner Syndrome After Carotid Artery Stenting. 颈动脉支架置入术后霍纳综合征的罕见病例
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-09-01 Epub Date: 2023-07-05 DOI: 10.1097/WNO.0000000000001918
Nozomi Sasaki, Yoshihito Hasegawa, Motoshi Sawada
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引用次数: 0
Paroxysmal Vertigo Associated With Periodic Alternating Nystagmus With Downbeat Component-A Rare Case of Hypomagnesemia. 阵发性眩晕伴有下跳成分的周期性交替眼震--低镁血症的罕见病例。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-09-01 Epub Date: 2023-08-07 DOI: 10.1097/WNO.0000000000001972
Xue Xu, Minping Li, Qiuhong Lin, Weiwei Qi, Junjie Guo, Haiwei Huang
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引用次数: 0
Diagnostic Yield of Investigations in Symmetric Optic Neuropathy. 对称性视神经病变的检查诊断率
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-09-01 Epub Date: 2023-08-24 DOI: 10.1097/WNO.0000000000001947
Armin Handzic, Jim S Xie, Edward A Margolin

Background: Symmetric optic neuropathy (SON) is commonly seen in neuro-ophthalmic practice and is often discovered incidentally. Although multiple investigations might be performed to discover the underlying cause, they are not always indicated. The aim of this study was to report a clinically reasonable and cost-effective approach to investigating patients with SON.

Methods: SON was defined as bilateral optic neuropathy with normal and/or symmetrically decreased central visual acuity, absence of relative afferent pupillary defect, presence of symmetric optic disc pallor, symmetric thinning of peripapillary retinal nerve fiber layer on optical coherence tomography, and absence of other identifiable causes of optic neuropathy. Records of all patients diagnosed with SON seen at a tertiary university-affiliated neuro-ophthalmology practice from 2016 to 2022 were reviewed to identify the yield of various investigations. Clinical data from the initial and last follow-up visit were obtained. Subgroup analysis was performed to ascertain whether diagnostic yield is higher in patients with severe visual loss (central acuity worse than 20/40) compared with those with mild visual loss (acuity 20/40 or better).

Results: One hundred thirty-six patients met inclusion criteria. Testing for OPA1 and OPA2 mutations had the highest diagnostic yield (16.0%), followed by mitochondrial genome sequencing (13.6%), serum vitamin B12 (6.1%), and serum folate (1.6%). MRI brain was performed in 54.4% of patients and had a diagnostic yield of only 5%. Both patients who had abnormal MRI had symptoms of demyelination at presentation. Patients were followed for a mean of 15.0 (SD 21.3) months. The most frequently identified etiologies of SON were Leber hereditary optic neuropathy (8.1%), alcohol/tobacco amblyopia (7.4%), vitamin B12 deficiency (5.9%), and dominant optic atrophy (2.9%). Patients with severe visual impairment were more likely to have a final diagnosis compared with those with milder visual impairment (63.9% vs 12.0%, P < 0.001).

Conclusions: The diagnostic yield of investigating SON in patients with preserved visual function, normal diet, and absence of other neurological symptoms is very low. It is reasonable to observe patients with SON with mild visual impairment, reserving costly investigations for those with the visual acuity worse than 20/40 or progressive course.

背景:对称性视神经病变(SON)常见于神经眼科临床,通常是偶然发现的。虽然可以进行多种检查以发现潜在病因,但并非总是适用。本研究旨在报告一种临床上合理且经济有效的方法,用于检查 SON 患者:SON 的定义是:双侧视神经病变,中心视力正常和/或对称下降,无相对传入性瞳孔缺损,存在对称性视盘苍白,光学相干断层扫描显示视网膜周围神经纤维层对称变薄,且无其他可确定的视神经病变原因。研究人员回顾了2016年至2022年期间在一所大学附属三级医院神经眼科就诊的所有确诊为SON患者的记录,以确定各种检查的结果。此外,还获取了初次和最后一次随访的临床数据。进行了分组分析,以确定重度视力丧失(中心视力低于20/40)患者的诊断率是否高于轻度视力丧失(视力20/40或更好)患者:结果:136 名患者符合纳入标准。OPA1和OPA2突变检测的诊断率最高(16.0%),其次是线粒体基因组测序(13.6%)、血清维生素B12(6.1%)和血清叶酸(1.6%)。54.4%的患者接受了脑部磁共振成像检查,诊断率仅为 5%。两名核磁共振成像异常的患者在发病时都有脱髓鞘症状。对患者的平均随访时间为 15.0 个月(标准差 21.3 个月)。SON 最常见的病因是 Leber 遗传性视神经病变(8.1%)、酒精/烟草弱视(7.4%)、维生素 B12 缺乏(5.9%)和显性视神经萎缩(2.9%)。与视力受损较轻的患者相比,视力受损严重的患者更有可能获得最终诊断(63.9% vs 12.0%,P < 0.001):结论:对视功能正常、饮食正常且无其他神经系统症状的患者进行SON检查的诊断率非常低。观察视力轻度受损的 SON 患者,为视力低于 20/40 或病程进展的患者保留昂贵的检查是合理的。
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引用次数: 0
Akinetopsia: A Systematic Review. Akinetopsia:系统综述。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-09-01 Epub Date: 2023-11-03 DOI: 10.1097/WNO.0000000000002032
Joshua M Van Swol, Elizabeth B Thompson, Jonah A Joffe, Shaun A Nguyen, Eric L Berman

Abstract: Selective motion blindness, also known as akinetopsia, is infrequently reported in the literature. Hence, little is known about the condition including its causes, time course, pathophysiology, and current diagnostic methods. In this investigation, we comprehensively surveyed the literature using a systematic review to identify each reported case of the condition. The purpose of this study was to provide an exhaustive catalog of every published occurrence to date to identify and discuss trends, commonalities, and differences among them. Our results revealed distinct characteristics for the various etiologies of this phenomenon in addition to a shared pathophysiologic pathway among them.

摘要:选择性运动盲,也称为无视症,在文献中很少报道。因此,人们对这种疾病知之甚少,包括其病因、时间过程、病理生理学和当前的诊断方法。在这项调查中,我们使用系统综述对文献进行了全面调查,以确定每一个报告的病例。本研究的目的是提供迄今为止每一次发表事件的详尽目录,以确定和讨论它们之间的趋势、共性和差异。我们的研究结果揭示了这种现象的各种病因的不同特征,以及它们之间共同的病理生理途径。
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引用次数: 0
Optic Disc Drusen Using Retromode Scanning Laser Ophthalmoscopy. 使用激光逆行扫描眼科检查的光盘Drusen。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-09-01 Epub Date: 2023-11-03 DOI: 10.1097/WNO.0000000000002035
Guido Ricciotti, Alexandra Miere, Donato Colantuono, Eric H Souied
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引用次数: 0
Impact of Diplopia and Ptosis From Lingering Third Nerve Palsy After Treatment of Cerebral Aneurysms. 脑动脉瘤治疗后第三神经麻痹遗留的复视和上睑下垂的影响
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-09-01 Epub Date: 2023-12-12 DOI: 10.1097/WNO.0000000000002052
Jeremy N Shapiro, Lindsey B Delott, Jonathan D Trobe

Background: Third nerve palsies (TNPs) may not resolve after intervention for intracranial aneurysms that have compressed the nerve. The disability related to this lingering condition has not been assessed with the support of patient self-report.

Methods: A single-institutional retrospective study of patients with TNP who had undergone interventions for intracranial aneurysms. We used residual primary-position diplopia, a narrow zone of single binocular vision, and vision-obscuring ptosis to divide TNP recovery into complete, incomplete nondisabling, and incomplete disabling outcomes based on medical record documentation and patient self-report derived from telephonic interviews.

Results: In a cohort of 33 patients, 13 (39%) had complete TNP recovery. There were 11 patients (33%) with lingering visual disability from diplopia or ptosis present before ophthalmic interventions. Of the 6 patients who underwent ophthalmic interventions, visual disability was relieved in only 2 patients, leaving 9 patients (27%) with lingering impairment in instrumental activities of daily living. Telephonic interviews of 23 patients (70% of the cohort) confirmed that the outcome criteria we applied were accurate in assessing visual disability in 17 patients (74%). Univariate analysis using the Fisher exact test showed that aneurysmal clipping as a treatment modality was the only clinical feature associated with a favorable TNP outcome.

Conclusions: In applying a novel method of assessing disability, this study showed that more than one-quarter of patients undergoing procedures for brain aneurysms had lingering disability from third nerve palsy-associated diplopia or ptosis, despite later ophthalmic interventions. Patient self-report gleaned from telephonic interviews was valuable in largely validating the assessment method derived from medical records and in revealing differences between physician and patient estimation of disability.

背景:对压迫神经的颅内动脉瘤进行干预后,第三神经麻痹(TNPs)可能不会缓解。目前还没有通过患者的自我报告来评估与这种挥之不去的病症相关的残疾情况:方法:对接受过颅内动脉瘤介入治疗的 TNP 患者进行单一机构回顾性研究。根据病历记录和电话访谈得出的患者自述,我们使用残留的原位复视、狭窄的单双眼视区和视力遮蔽性眼睑下垂将 TNP 恢复分为完全恢复、不完全非致残和不完全致残结果:在 33 位患者中,13 位(39%)TNP 完全恢复。有 11 名患者(33%)在接受眼科治疗前因复视或眼睑下垂而遗留视力残疾。在接受眼科干预的 6 名患者中,只有 2 名患者的视力残疾得到了缓解,其余 9 名患者(27%)的日常生活器质性活动障碍依然存在。对 23 名患者(占总数的 70%)进行的电话访谈证实,我们采用的结果标准能准确评估 17 名患者(74%)的视力残疾情况。使用费舍尔精确检验进行的单变量分析表明,动脉瘤剪切作为一种治疗方式是与 TNP 良好疗效相关的唯一临床特征:这项研究采用了一种新的残疾评估方法,结果表明,在接受脑动脉瘤手术的患者中,有四分之一以上的患者因第三神经麻痹相关的复视或上睑下垂而遗留残疾,尽管后来进行了眼科干预。通过电话访谈收集到的患者自我报告在很大程度上验证了从医疗记录中得出的评估方法,并揭示了医生和患者对残疾估计的差异,这一点非常有价值。
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引用次数: 0
Optic Nerve Sheath Meningiomas: A National Surveillance, Epidemiology, and End Results (SEER) Database Analysis. 视神经鞘脑膜瘤:全国监测、流行病学和最终结果 (SEER) 数据库分析。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-09-01 Epub Date: 2023-12-21 DOI: 10.1097/WNO.0000000000002048
Zain S Hussain, Asad Loya, Kamran M Riaz, Andrew G Lee

Background: Optic nerve sheath meningioma (ONSM) is a rare optic nerve cancer with considerable morbidity. This national analysis validates previously known ONSM concepts while providing insight into novel risk factors.

Methods: The Surveillance, Epidemiology, and End Results (SEER) Program was queried from 2000 to 2019 for all histologic subtypes of meningioma primary to the optic nerve. Relevant clinical and demographic variables were analyzed. Asymptotic one-sample test for binomial proportions and Cox proportional hazards modeling evaluated the significance of factor associations.

Results: A total of 51 ONSM cases were extracted. A greater proportion of cases were observed in females (N = 37, 73% , P < 0.001) and individuals with age 50 years or more (N = 29, 57% , P < 0.001); the mean number of months from diagnosis to treatment was 4.6 months (SD 4.1, range 13). Psychosocial epidemiologic parameter analysis demonstrated a greater proportion of patients with married status on diagnosis (N = 31, 61% , P < 0.001), listed total family income between $55,000 and $74,999 (N = 24, 47% , P < 0.001). Relative to cases diagnosed clinically only, cases diagnosed radiologically without microscopic confirmation experienced decreased all-cause mortality (HR = 0.041, P = 0.050).

Conclusions: Our SEER national analysis affirms previously characterized ONSM concepts. Upon ONSM diagnosis and if needed, treatment protocols are not significantly delayed. Novel psychosocial factors for ONSM were identified, including marital status, total family income, and non-Hispanic white race. Additional ONSM diagnostics may reduce longitudinal mortality burden.

背景:视神经鞘脑膜瘤(ONSM)是一种罕见的视神经癌症,发病率相当高。这项全国性分析验证了之前已知的 ONSM 概念,同时提供了对新风险因素的见解:方法:从 2000 年到 2019 年,对监测、流行病学和最终结果(SEER)计划中所有原发于视神经的脑膜瘤组织学亚型进行了查询。对相关的临床和人口统计学变量进行了分析。二项比例的渐近线单样本检验和Cox比例危险模型评估了因素关联的显著性:结果:共提取了 51 个 ONSM 病例。女性(N = 37,73%,P < 0.001)和年龄在 50 岁或以上者(N = 29,57%,P < 0.001)的病例比例更高;从诊断到治疗的平均月数为 4.6 个月(SD 4.1,范围 13)。社会心理流行病学参数分析显示,诊断时已婚的患者比例更高(N = 31,61%,P < 0.001),列出的家庭总收入在 55,000 美元至 74,999 美元之间(N = 24,47%,P < 0.001)。与仅经临床诊断的病例相比,未经显微镜确认的放射诊断病例的全因死亡率有所下降(HR = 0.041,P = 0.050):我们的 SEER 全国性分析证实了之前的 ONSM 概念。结论:我们的 SEER 全国分析证实了之前的 ONSM 概念。我们发现了导致ONSM的新的社会心理因素,包括婚姻状况、家庭总收入和非西班牙裔白人种族。额外的 ONSM 诊断可减少纵向死亡率负担。
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引用次数: 0
The Academy of Neurology Was Held in the Mile High City, Denver, Colorado, April 13-18, 2024. 神经病学学会于 2024 年 4 月 13 日至 18 日在科罗拉多州丹佛市一英里高城举行。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-09-01 Epub Date: 2024-06-17 DOI: 10.1097/WNO.0000000000002190
Aileen A Antonio, Valerie Biousse, Nancy J Newman, Kathleen B Digre
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引用次数: 0
期刊
Journal of Neuro-Ophthalmology
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