Pub Date : 2020-07-17DOI: 10.35248/2157-7439.20.11.546
A. Butterfield, Binghui Wang, Peng Wu, Sarita S. Hardas, J. Unrine, E. Grulke, Jian Cai, J. Klein, W. Pierce, R. Yokel, R. Sultana
Nanoceria (CeO2, cerium oxide nanoparticles) is proposed as a therapeutic for multiple disorders. In blood, nanoceria becomes protein-coated, changing its surface properties to yield a different presentation to cells. There is little information on the interaction of nanoceria with blood proteins. The current study is the first to report the proteomics identification of plasma and serum proteins adsorbed to nanoceria. The results identify a number of plasma and serum proteins interacting with nanoceria, proteins whose normal activities regulate numerous cell functions: antioxidant/detoxification, energy regulation, lipoproteins, signaling, complement, immune function, coagulation, iron homeostasis, proteolysis, inflammation, protein folding, protease inhibition, adhesion, protein/RNA degradation, and hormonal. The principal implications of this study are: 1) The protein corona may positively or negatively affect nanoceria cellular uptake, subsequent organ bioprocessing, and effects; and 2) Nanoceria adsorption may alter protein structure and function, including pro- and inflammatory effects. Consequently, prior to their use as therapeutic agents, better understanding of the effects of nanoceria protein coating is warranted.
{"title":"Plasma and Serum Proteins Bound to Nanoceria: Insights into Pathways by which Nanoceria may Exert Its Beneficial and Deleterious Effects In Vivo","authors":"A. Butterfield, Binghui Wang, Peng Wu, Sarita S. Hardas, J. Unrine, E. Grulke, Jian Cai, J. Klein, W. Pierce, R. Yokel, R. Sultana","doi":"10.35248/2157-7439.20.11.546","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.546","url":null,"abstract":"Nanoceria (CeO2, cerium oxide nanoparticles) is proposed as a therapeutic for multiple disorders. In blood, nanoceria becomes protein-coated, changing its surface properties to yield a different presentation to cells. There is little information on the interaction of nanoceria with blood proteins. The current study is the first to report the proteomics identification of plasma and serum proteins adsorbed to nanoceria. The results identify a number of plasma and serum proteins interacting with nanoceria, proteins whose normal activities regulate numerous cell functions: antioxidant/detoxification, energy regulation, lipoproteins, signaling, complement, immune function, coagulation, iron homeostasis, proteolysis, inflammation, protein folding, protease inhibition, adhesion, protein/RNA degradation, and hormonal. The principal implications of this study are: 1) The protein corona may positively or negatively affect nanoceria cellular uptake, subsequent organ bioprocessing, and effects; and 2) Nanoceria adsorption may alter protein structure and function, including pro- and inflammatory effects. Consequently, prior to their use as therapeutic agents, better understanding of the effects of nanoceria protein coating is warranted.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":"395 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77765019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-01DOI: 10.26420/austinjnanomednanotechnol.2020.1058
J. Xu, S. Xu
{"title":"On The Short Delay in Neighboring Neural Pulses","authors":"J. Xu, S. Xu","doi":"10.26420/austinjnanomednanotechnol.2020.1058","DOIUrl":"https://doi.org/10.26420/austinjnanomednanotechnol.2020.1058","url":null,"abstract":"","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89868486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The analysis of silver nanoparticle (NP-Ag) by the single particle technique with argon plasma-coupled mass spectrometry (SP-ICP-MS) is an increasingly used analytical approach. The sensitive technique, distinguishing particle size distribution, allows working at concentrations similar to those found in environmental samples. The two natural Ag isotopes 107 and 109, with abundances of 52 and 48% respectively, have similar sensitivity in ICP-MS detection. However, it is common to encounter isobaric interferences in mass spectrometry, and the element silver is not an exception, as much with the 107 isotope as 109. For both isotopes, zirconium oxides present isobaric interferences, either 91Zr16O, 90Zr16O1H for the isotope 107 and the 92Zr16O1H for the 109. Results: For surface water analysis by ICP-MS in regular technique, these interferences do not generally impact the analysis of total Ag concentrations (mainly dissolved) as they can be then simply subtracted like background signal. On the other hand, detection of NPAg was impacted by the interfering colloidal Zr. The analysis of Zr by the SP-ICP-MS technique of surface waters showed the presence of colloidal Zr, a random signal that cannot be simply subtracted from NP Ag signal. Our results show that, Zr colloids are effectively interfering with the NP-Ag assays by SP-ICP-MS technique where interferences translated into a false positive. Conclusion: The analytical issue related isobaric interferences from the naturally occurring colloidal Zr was attenuated (up to 250% in this assay) by the use of the 109 isotope in the Ag detection, limiting false positive detections and improving the reliability of NP-Ag measurements in natural waters. Therefore , more specific detection of NP Ag in surface waters that naturally contain Zr colloids can be accomplished.
{"title":"Zirconium interferences on the detection of silver nanoparticles by single particle ICP-MS: implications on natural water analysis","authors":"P. Turcotte, C. Gagnon","doi":"10.21203/rs.2.22297/v1","DOIUrl":"https://doi.org/10.21203/rs.2.22297/v1","url":null,"abstract":"\u0000 Background: The analysis of silver nanoparticle (NP-Ag) by the single particle technique with argon plasma-coupled mass spectrometry (SP-ICP-MS) is an increasingly used analytical approach. The sensitive technique, distinguishing particle size distribution, allows working at concentrations similar to those found in environmental samples. The two natural Ag isotopes 107 and 109, with abundances of 52 and 48% respectively, have similar sensitivity in ICP-MS detection. However, it is common to encounter isobaric interferences in mass spectrometry, and the element silver is not an exception, as much with the 107 isotope as 109. For both isotopes, zirconium oxides present isobaric interferences, either 91Zr16O, 90Zr16O1H for the isotope 107 and the 92Zr16O1H for the 109. Results: For surface water analysis by ICP-MS in regular technique, these interferences do not generally impact the analysis of total Ag concentrations (mainly dissolved) as they can be then simply subtracted like background signal. On the other hand, detection of NPAg was impacted by the interfering colloidal Zr. The analysis of Zr by the SP-ICP-MS technique of surface waters showed the presence of colloidal Zr, a random signal that cannot be simply subtracted from NP Ag signal. Our results show that, Zr colloids are effectively interfering with the NP-Ag assays by SP-ICP-MS technique where interferences translated into a false positive. Conclusion: The analytical issue related isobaric interferences from the naturally occurring colloidal Zr was attenuated (up to 250% in this assay) by the use of the 109 isotope in the Ag detection, limiting false positive detections and improving the reliability of NP-Ag measurements in natural waters. Therefore , more specific detection of NP Ag in surface waters that naturally contain Zr colloids can be accomplished.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":"26 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90635177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Allan D Butterfield, Binghui Wang, Peng Wu, Sarita S Hardas, Jason M Unrine, Eric A Grulke, Jian Cai, Jon B Klein, William M Pierce, Robert A Yokel, Rukhsana Sultana
Nanoceria (CeO2, cerium oxide nanoparticles) is proposed as a therapeutic for multiple disorders. In blood, nanoceria becomes protein-coated, changing its surface properties to yield a different presentation to cells. There is little information on the interaction of nanoceria with blood proteins. The current study is the first to report the proteomics identification of plasma and serum proteins adsorbed to nanoceria. The results identify a number of plasma and serum proteins interacting with nanoceria, proteins whose normal activities regulate numerous cell functions: antioxidant/detoxification, energy regulation, lipoproteins, signaling, complement, immune function, coagulation, iron homeostasis, proteolysis, inflammation, protein folding, protease inhibition, adhesion, protein/RNA degradation, and hormonal. The principal implications of this study are: 1) The protein corona may positively or negatively affect nanoceria cellular uptake, subsequent organ bioprocessing, and effects; and 2) Nanoceria adsorption may alter protein structure and function, including pro- and inflammatory effects. Consequently, prior to their use as therapeutic agents, better understanding of the effects of nanoceria protein coating is warranted.
{"title":"Plasma and Serum Proteins Bound to Nanoceria: Insights into Pathways by which Nanoceria may Exert Its Beneficial and Deleterious Effects <i>In Vivo</i>.","authors":"Allan D Butterfield, Binghui Wang, Peng Wu, Sarita S Hardas, Jason M Unrine, Eric A Grulke, Jian Cai, Jon B Klein, William M Pierce, Robert A Yokel, Rukhsana Sultana","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nanoceria (CeO<sub>2</sub>, cerium oxide nanoparticles) is proposed as a therapeutic for multiple disorders. In blood, nanoceria becomes protein-coated, changing its surface properties to yield a different presentation to cells. There is little information on the interaction of nanoceria with blood proteins. The current study is the first to report the proteomics identification of plasma and serum proteins adsorbed to nanoceria. The results identify a number of plasma and serum proteins interacting with nanoceria, proteins whose normal activities regulate numerous cell functions: antioxidant/detoxification, energy regulation, lipoproteins, signaling, complement, immune function, coagulation, iron homeostasis, proteolysis, inflammation, protein folding, protease inhibition, adhesion, protein/RNA degradation, and hormonal. The principal implications of this study are: 1) The protein corona may positively or negatively affect nanoceria cellular uptake, subsequent organ bioprocessing, and effects; and 2) Nanoceria adsorption may alter protein structure and function, including pro- and inflammatory effects. Consequently, prior to their use as therapeutic agents, better understanding of the effects of nanoceria protein coating is warranted.</p>","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":"11 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39471217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2157-7439.20.11.E537
A. Ostafin
{"title":"Research Highlights of Contemporary Nanoscience and Nanotechnology with Biomedical Applications","authors":"A. Ostafin","doi":"10.35248/2157-7439.20.11.E537","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.E537","url":null,"abstract":"","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":"12 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87486369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2157-7439.20.11.E538
A. Ostafin
Journal of Nanomedicine and Nanotechnology publishes peerreviewed articles in diverse fields of Nanoscience research having biological and clinical relevance. The Journal focuses on research pertaining to the synthesis and characterization of nanomaterials as well as evaluation of their potential pharmacological and therapeutic effects. In the current year, the Journal has published fourteen peer-reviewed articles elucidating the role of Nanoscience and Nanotechnology in developing biomedical and environmental applications, contributed by over 55 International authors from diverse regions of the world. This sixth issue of the current year focuses exclusively on design, development, characterization and performance optimization of nanomaterials for accurate drug delivery and enhanced therapeutic potential. Targeted drug deliver significantly enhances the drug efficiency and efficacy even with low dose and also facilitates the delivery of non-soluble drugs.
{"title":"Novel Nanotechnology based Approaches for Targeted Drug Delivery and Effective Therapy","authors":"A. Ostafin","doi":"10.35248/2157-7439.20.11.E538","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.E538","url":null,"abstract":"Journal of Nanomedicine and Nanotechnology publishes peerreviewed articles in diverse fields of Nanoscience research having biological and clinical relevance. The Journal focuses on research pertaining to the synthesis and characterization of nanomaterials as well as evaluation of their potential pharmacological and therapeutic effects. In the current year, the Journal has published fourteen peer-reviewed articles elucidating the role of Nanoscience and Nanotechnology in developing biomedical and environmental applications, contributed by over 55 International authors from diverse regions of the world. This sixth issue of the current year focuses exclusively on design, development, characterization and performance optimization of nanomaterials for accurate drug delivery and enhanced therapeutic potential. Targeted drug deliver significantly enhances the drug efficiency and efficacy even with low dose and also facilitates the delivery of non-soluble drugs.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":"5 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84139273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2157-7439.20.11.548
P. Iversen, T. Porter, N. Kipshidze, N. Kipshidze
No definitive therapies for COVID-19 have yet to be identified. The several hundred planned or ongoing clinical trials globally will provide some insights into therapies that may or may not work. The overwhelming majority of therapeutics relies on the systemic delivery of drugs; however, COVID-19 is largely localized to the lungs with some subgroups afflicted in other organ systems. We propose the use of a targeted drug delivery approach in which therapeutics can be delivered using engineered delivery vehicles to reach damaged lung tissue directly.
{"title":"Targeted Site-Specific Therapeutics for COVID-19","authors":"P. Iversen, T. Porter, N. Kipshidze, N. Kipshidze","doi":"10.35248/2157-7439.20.11.548","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.548","url":null,"abstract":"No definitive therapies for COVID-19 have yet to be identified. The several hundred planned or ongoing clinical trials globally will provide some insights into therapies that may or may not work. The overwhelming majority of therapeutics relies on the systemic delivery of drugs; however, COVID-19 is largely localized to the lungs with some subgroups afflicted in other organ systems. We propose the use of a targeted drug delivery approach in which therapeutics can be delivered using engineered delivery vehicles to reach damaged lung tissue directly.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":"33 5","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91426696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2157-7439.19.10.543
S. Khaturia, M. Chahar, H. Sachdeva, Sangeeta, Mahto Cb
{"title":"A Review: The Uses of Various Nanoparticles in Organic Synthesis","authors":"S. Khaturia, M. Chahar, H. Sachdeva, Sangeeta, Mahto Cb","doi":"10.35248/2157-7439.19.10.543","DOIUrl":"https://doi.org/10.35248/2157-7439.19.10.543","url":null,"abstract":"","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75524537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2157-7439.20.10.E535
A. Ostafin
Nanotechnology based approaches find unprecedented application in the field of medicine and facilitation of safe and sustainable environment. Nevertheless, the key challenge lies in identifying and addressing their consequences on human health and environmental viability as well as understanding the underlying processes based on nanoparticle specific interactions. The research, review and editorial observations published as constituents of second issue in the journal of the current year, verily explores these dimensions of nanotechnology. Specifically, these articles focus on silver nanoparticle rinse based tooth enamel remineralization-hardening; the role of metal nanoparticles in environmental friendly industrial reactions as well as the need to develop nanotechnological approaches to comprehensively fight the current COVID-19 pandemic.
{"title":"Current Relevance of Nanotechnology to Medicine and Industry","authors":"A. Ostafin","doi":"10.35248/2157-7439.20.10.E535","DOIUrl":"https://doi.org/10.35248/2157-7439.20.10.E535","url":null,"abstract":"Nanotechnology based approaches find unprecedented application in the field of medicine and facilitation of safe and sustainable environment. Nevertheless, the key challenge lies in identifying and addressing their consequences on human health and environmental viability as well as understanding the underlying processes based on nanoparticle specific interactions. The research, review and editorial observations published as constituents of second issue in the journal of the current year, verily explores these dimensions of nanotechnology. Specifically, these articles focus on silver nanoparticle rinse based tooth enamel remineralization-hardening; the role of metal nanoparticles in environmental friendly industrial reactions as well as the need to develop nanotechnological approaches to comprehensively fight the current COVID-19 pandemic.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":"4 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87547881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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