Journal of Nutrition and Metabolism最新文献

Genistein[5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one] is a phytoestrogens known to positively impact various cardiovascular disease (CVD) risk factors. However, not all studies have yielded consistent results, and existing meta-analyses have not comprehensively addressed all CVD risk factors. We conducted a systematic search of the PubMed, ISI Web of Science, Embase, and Cochrane Library databases up to June 2024, following PRISMA 2020 guidelines. We included adult randomized controlled trials (RCTs) that examined pure genistein supplementation without other combined interventions and reported on at least one CVD risk factor. Data extraction and quality assessment were performed independently by two authors using a standardized form and the Cochrane Collaboration Scale. A total of 21 RCTs were included, with 941 participants in the genistein supplementation group and 918 participants in the control group. Statistical analyses were conducted using R software with the meta package. The meta-analysis revealed that, compared to the placebo group, genistein supplementation significantly improved the levels of TC ([MD 95% CI: -9.38 [-14.64, -4.12]; p < 0.001]), LDL-C ([MD 95% CI: -11.14 [-19.42, -2.86]; p < 0.001]), Lp(a) levels ([MD 95% CI: -0.69 [-0.98, -0.41]; p < 0.01), SBP ([MD 95% CI: -8.32 [-12.44, -4.20]; p < 0.01), DBP ([MD 95% CI: -3.57 [-5.25, -1.89]; P=0.04]), fasting blood glucose ([MD 95% CI: -3.98 [-6.79, -1.17]; p < 0.001]), fasting insulin ([MD 95% CI: -1.79 [-2.05, -1.54]; p < 0.01), HOMA-IR ([MD 95% CI: -0.56 [-0.64, -0.49]; p < 0.01), and homocysteine levels ([MD 95% CI: -0.74 [-1.05, -0.42]; p < 0.01). However, there were no significant improvements in TG, HDL-C, and CRP levels. The observed improvements align with clinically meaningful thresholds for cardiovascular risk reduction. Substantial heterogeneity observed for most outcomes was explored via subgroup analysis. Subgroup analyses were conducted based on treatment duration, geographic region, or participant health status, and heterogeneity was assessed using the I ² statistic. Subgroup analysis did not reveal any significant differences, indicating that heterogeneity was not influenced by factors such as treatment duration, geographic region, or participant health status. Overall, this meta-analysis provides consistent evidence that genistein intake significantly reduces several important CVD risk factors, including TC, LDL-C, Lp(a), SBP, DBP, fasting blood glucose, fasting insulin, HOMA-IR, and homocysteine levels.

Background: Depression and anxiety are common in UC patients due to gut microbiota dysbiosis and increased proinflammatory markers. Butyrate, a short-chain fatty acid, participates in the regulation of gut microbiota and inflammation and has neuroprotective effects in neurodegenerative disease. Therefore, we assessed the effects of sodium butyrate supplementation on the disease severity, inflammation, and psychological factors in active UC patients. Methods: This study was a randomized, parallel, double-blind controlled trial. Participants in the intervention (n = 18) and control (n = 18) groups received 600 mg/kg of sodium butyrate or rice starch as a placebo with their main meal, respectively, for 12 weeks. The partial Mayo score was used to evaluate disease severity, while the Westergren method was employed to assess the erythrocyte sedimentation rate (ESR). NLR and PLR were determined using an automated analyzer (XS-500i, Sysmex). Moreover, the psychological factors were assessed by the hospital anxiety depression scale (HADS) and the general health questionnaire (GHQ). Results: In comparison with placebo, sodium-butyrate supplementation significantly decreased the ESR level (-6.66 ± 1.56 vs. 3.00 ± 2.11, p=0.01), NLR (-0.24 ± 0.1 vs. 0.33 ± 0.23, p=0.02), Mayo score (-2.33 ± 0.41 vs. 0.22 ± 0.40, p < 0.001), HADS anxiety score (-2.77 ± 0.64 vs. 0.94 ± 0.63, p=0.001), HADS depression score (-2.38 ± 0.47 vs. 0.61 ± 0.33, p < 0.001), and GHQ total score (-12.11 ± 1.48 vs. 3.55 ± 1.39, p < 0.001). Conclusion: Butyrate could serve as an effective adjuvant treatment for reducing disease severity and alleviating psychological symptoms. This trial was registered on the Research Ethics Committee of Shiraz University of Medical Sciences, with the reference number IR.SUMS.SCHEANUT.REC.1400.037. Trial Registration: Iranian Registry of Clinical Trials: IRCT20211214053401N1.

Objective: This study has been conducted to identify the frequency of malnutrition and different factors associated with it among elderly people with Type 2 diabetes. Methods: This cross-sectional study was conducted in the National Institute of Diabetes and Endocrinology (NIDE), DUHS, Karachi, between January 2023 and October 2023. A total of 325 elderly participants aged ≥ 60 years with Type 2 diabetes were included. Mini Nutritional Assessment (MNA) was used for data collection. Results: Nutritional assessment of older diabetic patients according to the MNA revealed that 226 (69.5%) patients were at risk of malnutrition whereas 53 (16.3%) were malnourished. A total of 325 Type 2 diabetic patients were included in the study with a mean age of 65.7 ± 5.5 years, where 135 (41.5%) were male and 190 (58.5%) were female. Older patients (mean age: 65 years) were significantly more malnourished compared to those with normal nutrition (mean age: 62 years; p=0.021). Employed patients were less likely to have the risk of malnutrition as compared to housewives (p=0.005). Patients who had low family income were eight times more likely to be malnourished as compared to those who had better family income (p=0.003). It was also found that patients with low BMI and calf circumference will be more prone to be malnourished as compared to those with high levels of BMI (p=0.003) and calf circumference (p=0.013). Conclusion: The majority of study participants were at risk of malnourishment, with associated factors such as rapid weight loss, poor health status, decline in physical activity, and food intake. Therefore, these findings highlight the importance of tailored interventions for at-risk individuals, including regular screening and nutritional support.

Background: Childhood obesity is a global issue with multifactorial causes, leading to chronic and complex disease affecting all organs and systems with high morbidity and mortality, later in life. Elevated serum uric acid (SUA) levels are linked to several comorbidities in adults. In children, however, SUA levels vary by age, sex, and pubertal stage, and therefore, this relation is not well documented. While higher body mass index (BMI) has been associated with SUA levels, other nutritional assessment methods have not been thoroughly investigated and the link between SUA levels and obesity comorbidities in children is underexplored. Objective: This study aims to determine if hyperuricemia is related to body composition and obesity-related comorbidities in children. Methods: A retrospective analysis examined records from 505 obese children aged 5 to 18. The study evaluated the relationship between three nutritional assessment methods: BMI, waist-to-height ratio (WHtR), and body fat mass (BFM) percentage determined by bioimpedance (using InBody 270 scale), SUA levels, and blood markers associated with target organ damage. Results: A significant correlation was found between all three nutritional assessment methods (p < 0.001). WHtR showed a stronger correlation with the assessed comorbidities than the BMI z-score. SUA level correlated with HOMA-IR, ALT level, and lipid profile (p < 0.001). Multiple linear regression indicated an association between SUA level, BFM percentage, and WHtR (p < 0.001). Significant differences in body composition, SUA, and comorbidity markers were observed between children with and without hepatic steatosis (p < 0.05). Conclusion: Our results indicated a strong correlation among all nutritional assessment methods; however, WHtR and BFM percentage had a better correlation with obesity complications. SUA is a potential marker for insulin resistance, inflammation, and metabolic dysfunction-associated fatty liver disease (MAFLD) in obese children.

Background and Aim: Emotional eating (EE) is the uncontrollable desire to eat in response to negative emotions such as anxiety, irritation, or depression. The 2019 coronavirus (COVID-19) pandemic and strict quarantine raised the likelihood of mental symptoms and, as a consequence, EE. The main objective of this study was to assess the extent of EE and mental health among Lebanese university students and to identify the main correlates of EE. Methods: A cross-sectional study was undertaken between March and April 2021. Overall, 356 Lebanese university students aged between 18 and 25 years completed an online questionnaire that assesses EE and mental state, as well as health and eating habits. Results: The total mean EE score was 33.82 (±8.52). The main predictors of EE among university students were a higher grade point average (GPA) (p=0.010), higher body mass index (BMI) (p < 0.001), consuming more fats (p=0.013), and eating more sweets and cookies (p=0.010). In addition, depression, anxiety, and stress were highly prevalent among Lebanese university students during the pandemic (43.8%, 51.7%, and 91.6%, respectively). Conclusion: This study provides evidence of the negative impact of the COVID-19 outbreak on emotional well-being and eating behaviors among Lebanese university students. Targeted nutrition education programs that address the cultural and economic realities of Lebanese students, as well as psychological counseling offered by the universities, would be of interest to improve the diet quality and emotional well-being of the students.

Introduction: Despite efforts to address malnutrition, it remains prevalent in Ghana and other developing nations. High rates of malnutrition hinder the achievement of the health-related sustainable development goals. Understanding the factors contributing to undernutrition among pregnant women (PW) is essential for developing targeted interventions. This study, therefore, aims to assess the prevalence of undernutrition, dietary diversity (DD), and predictors of undernutrition among PW in Effutu Municipality in the Central Region of Ghana. Methods: Two hospitals within the Effutu Municipality were recruited for the study. The study was conducted among 301 PW (15-49 years) recruited through simple random sampling from September 20, 2022, to October 24, 2022. The mid-upper arm circumference and minimum DD score for women were used as a proxy for undernutrition and DD, respectively. SPSS version 26 was used for data analysis. Descriptive statistics, bivariate analysis, and binary regression analysis were conducted to describe variables and identify the association between dependent and independent variables. Results: The majority of the respondents (40.5%) were in the age range of 26-30 years and were single (53.2%). The prevalence of undernutrition was 9.3%, while 7.6% of the respondents had poor DD scores. Factors identified to be associated with undernutrition were DD score (OR = 15.244, 95% CI: 5.399-43.040), employment status (OR = 3.311, 95% CI: 1.075-10.195), and parity (OR = 2.903, 95% CI: 1.125-7.492). Conclusion: Effutu Municipality in Ghana faces a moderate prevalence of undernutrition among PW, despite generally adequate DD. Targeted interventions focusing on improving DD, particularly among unemployed and multiparous women, are essential for addressing undernutrition and improving maternal and fetal health outcomes in the study area. These findings underscore the importance of context-specific strategies to combat malnutrition among PW.

Introduction: This study explores the impact of observing Ramadan intermittent fasting (RIF) on body weight in Turkish residents, marking it as the first study conducted in Turkey to investigate the interplay of religious fasting with dietary changes amid the COVID-19 pandemic. We hypothesized that observing Ramadan fasting would result in weight loss attributable to dietary changes, while decreased physical activity would correlate with weight gain during this period. Methods: A cross-sectional survey was conducted among Muslims aged 18+ in Turkey who fasted at least two days during Ramadan 2021. Data were collected via Google Forms, with 1669 participants recruited through social media. Descriptive statistics summarized participant characteristics, and Pearson's Chi-square tests assessed weight change differences. Binary logistic regression identified predictors of weight gain, adjusting for factors such as sex, age, physical activity, water consumption, and diet. Results: Of the 1669 respondents (53.6% female), 49.4% perceived their weight as normal, while 47.0% classified themselves as overweight or obese. Logistic regression indicated that decreased physical activity (AOR = 1.618, p=0.001) and increased fat intake (AOR = 1.9, 95% CI 1.2-2.9) were significant predictors of weight gain. Conclusion: Our findings emphasize the importance of promoting healthy eating and regular physical activity during Ramadan.

To achieve the Sustainable Development Goals by 2030, low-income countries like Ghana will require strategizing towards sustainable reduction in micronutrient deficiency (MND) diseases and MND-related morbidity and mortality. A scoping review was conducted to identify the policy framework around MND intervention, the actors implementing MND-related strategies and documented evidence on which strategies worked across implementation stakeholders. Forty-six peer-reviewed articles were selected (n = 46) including studies on nutrition-sensitive intervention studies (n = 15) and nutrition-specific intervention (n = 31). Eligibility criteria for inclusion of information from articles and publications were based on report findings on nutrition-related programmes and policies conducted and implemented in Ghana and should have been published between 2000 and 2024. Databases adopted for this scoping review include Google Scholar, PubMed, ScienceDirect, AGORA, Hinari and JSTOR. This scoping review obtained a comprehensive picture of the nutrition situation in Ghana by gathering nutrition surveillance data depicting the different strategies employed to combat MNDs in Ghana. The scoping review identified several MND intervention strategies; however, the sustainability of the strategies required effective implementation guidelines, policies and programmes that address dietary deficits specific to a particular population.

Tocotrienols, isomers of vitamin E, may provide an effective nutritional strategy to mitigate common cardiovascular risks such as dyslipidemia, inflammation, and oxidative stress in patients with chronic kidney disease (CKD). This double-blind, placebo-controlled, randomized clinical trial aimed to evaluate the effects of a tocotrienol-rich fraction (TRF) supplementation (300 mg/day) on oxidative stress and inflammatory markers, including transcription factors in nondialysis (ND) and hemodialysis (HD) CKD patients for three months. Interleukin-6, tumor necrosis factor-α (IL-6 and TNF-α), C-reactive protein (CRP), lipid peroxidation, biochemical parameters, and transcription factors such as NRF2 and NF-κB mRNA expression were evaluated. Seventeen HD patients (9 in the placebo group, 8 in the TRF group) and 16 ND CKD patients (8 in the placebo group and 8 in the TRF group) completed the study. In HD patients, significant reductions were observed in LDL cholesterol (p=0.04) and total plasma cholesterol levels (p=0.01) after TRF intervention. CRP serum levels decreased significantly in ND CKD patients (p=0.05) after TRF supplementation. Transcription factors NRF2 and NF-κB mRNA expressions remained unaltered in both groups. This study suggests that TRF supplementation may mitigate dyslipidemia and inflammation, factors involved with increased cardiovascular risk, in CKD patients, with variations in efficacy between HD and ND patients. Trial Registration: ClinicalTrials.gov identifier: NCT04900532.

A rise in body temperature caused by physical work, including exercise, in a hot climate can lead to heat-related illnesses such as exertional heat exhaustion and stroke. Individuals who work physically demanding occupations in hot environments are at heightened risk of heat injury. The mechanisms that contribute to heat illness resulting from physical work in the heat are complex and include dehydration, tissue ischemia and damage, oxidative stress, and inflammatory events. Therefore, it is important to develop strategies that address these mechanistic underpinnings to prevent exacerbation to heat illness. Glutamine is an amino acid that has been considered conditionally essential during situations of biological stress (e.g., tissue burn, exercise, sepsis) due to high rates of tissue consumption. Evidence suggests that glutamine may serve as an important nutrient during heat stress and when combined with other preventative measures (e.g., cooling techniques, work/rest ratios, clothing) may help to mitigate heat illness among individuals working in extreme climates. The aim of this review is to examine the current literature on the role of glutamine during heat stress.