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Caffeine Consumption among Various University Students in the UAE, Exploring the Frequencies, Different Sources and Reporting Adverse Effects and Withdrawal Symptoms 阿联酋不同大学生的咖啡因消费,探索频率,不同来源和报告不良反应和戒断症状
IF 2.2 Q3 NUTRITION & DIETETICS Pub Date : 2022-05-18 DOI: 10.1155/2022/5762299
Z. Kharaba, Nour Sammani, Samar Ashour, R. Ghemrawi, Ahmad Z. Al Meslamani, Ahmad Al-Azayzih, M. Buabeid, Y. Alfoteih
Background Caffeine is widely consumed among students due to its cognitive and physical enhancing effects. However, little is known about the consumption pattern of different caffeinated products among university students in the United Arab Emirates (UAE). Aim To investigate the frequency of caffeine consumption among the young population of students, assess types of caffeinated products consumed, and document adverse effects and withdrawal symptoms experienced by university students. Methods A cross-sectional study was conducted in the UAE from December 2019 to March 2020. A random sample of 500 university students from different universities in the UAE were approached and asked to complete a self-administered online-based questionnaire. Data were analyzed using the Statistical Package for Social Science (SPSS) version 26. Results Of (n = 500) surveyed students, (n = 467) completed the survey 93.4%. The average level of caffeine consumption was significantly higher in females compared to male students (p < 0.005). Coffee was the highest favored source of caffeine (67.7%) followed by tea (47.3%). The average daily intake of caffeine was found to be 264 mg/day. Surprisingly, almost a third of students reported a high level of daily consumption (>400 mg/day) and more than half of them consumed less than 199 mg/day. Large proportions of students 91.1% have their caffeinated beverage after or while eating meals and 42.8% considered that this habit helped in avoiding acid reflux. Interestingly, around one third of participants have poor knowledge of caffeine-containing medical products, which seemed to affect the level of consumption in the student population (p < 0.05). The highest reported reason for caffeine intake was for studying purposes (59.4%). Conclusion Caffeine consumption is highly prevalent among university students in the UAE. Yet, there is insufficiency in the current knowledge of safe caffeine consumption patterns reflecting the importance of health awareness programs and nutritional lectures to decrease the long-term health issues and unintentional overdose of caffeine.
背景咖啡因因其增强认知和身体机能的作用而在学生中被广泛食用。然而,人们对阿拉伯联合酋长国大学生不同含咖啡因产品的消费模式知之甚少。目的调查年轻学生摄入咖啡因的频率,评估摄入的含咖啡因产品的类型,并记录大学生的不良反应和戒断症状。方法2019年12月至2020年3月在阿联酋进行横断面研究。随机抽取来自阿联酋不同大学的500名大学生,要求他们完成一份基于网络的自我管理问卷。使用社会科学统计软件包(SPSS)第26版对数据进行分析。结果(n = 500)受访学生,(n = 467)完成了93.4%的调查。女性学生的咖啡因平均摄入量明显高于男性学生(p<0.005)。咖啡是最受欢迎的咖啡因来源(67.7%),其次是茶(47.3%)。咖啡因的平均每日摄入量为264 mg/天。令人惊讶的是,近三分之一的学生表示日常消费水平很高(>400 mg/天),其中一半以上的消耗量低于199 mg/天。91.1%的学生在饭后或用餐时喝含咖啡因的饮料,42.8%的学生认为这种习惯有助于避免胃酸倒流。有趣的是,大约三分之一的参与者对含咖啡因的医疗产品知之甚少,这似乎会影响学生群体的消费水平(p<0.05)。据报道,摄入咖啡因的最高原因是出于学习目的(59.4%)。结论咖啡因消费在阿联酋大学生中非常普遍。然而,目前对安全咖啡因消费模式的了解还不够,这反映了健康意识计划和营养讲座对减少长期健康问题和意外过量摄入咖啡因的重要性。
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引用次数: 7
Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes 硒补充对妊娠-孕产妇和新生儿结局的影响
IF 2.2 Q3 NUTRITION & DIETETICS Pub Date : 2022-05-04 DOI: 10.1155/2022/4715965
K. Biswas, J. McLay, F. Campbell
Background Several studies have suggested that increased oxidative stress during pregnancy may be associated with adverse maternal and foetal outcomes. As selenium is an essential mineral with an antioxidant role, our aim was to perform a systematic review of the existing literature reporting the effects of selenium supplementation during pregnancy on maternal and neonatal outcomes. Materials and Methods Six electronic databases (Medline, Embase, Cochrane Library, Web of Science, Scopus, and PubMed) were searched for studies reporting the effects of selenium supplementation during pregnancy and the postpartum period on maternal and neonatal outcomes. Only randomised controlled trials on human subjects reported in English and published up to October 2021 were included. Quality assessments were conducted using the modified Downs and Black quality assessment tool. Data were extracted using a narrative synthesis. Results Twenty-two articles were included in our systematic review (seventeen reported on maternal outcomes, two on newborn outcomes, and three on both). Maternal studies reported the effects of selenium supplementation in the prevention of thyroid dysfunction, gestational diabetes, pregnancy-induced hypertension/preeclampsia, oxidative stress, postpartum depression, premature rupture of membranes, intrauterine growth retardation, breastmilk composition, and HIV-positive women. Newborn studies reported the effects of maternal selenium supplementation on foetal oxidation stress, foetal lipid profile, neonatal hyperbilirubinemia, and newborn outcomes in HIV-positive mothers. The majority of studies were inappropriately designed to establish clinical or scientific utility. Of interest, four studies reported that selenium supplementation reduced the incidence of thyroid dysfunction and permanent hypothyroidism during the postpartum period by reducing thyroid peroxidase and thyroglobulin antibody titres. Conclusion The evidence supporting selenium supplementation during pregnancy is poor and there is a need for appropriately designed randomised controlled trials before routine use can be recommended.
背景几项研究表明,妊娠期间氧化应激的增加可能与母体和胎儿的不良结局有关。由于硒是一种具有抗氧化作用的必需矿物质,我们的目的是对现有文献进行系统综述,这些文献报道了孕期补充硒对孕产妇和新生儿结局的影响。材料和方法检索6个电子数据库(Medline、Embase、Cochrane Library、Web of Science、Scopus和PubMed),研究妊娠期和产后补硒对孕产妇和新生儿结局的影响。仅包括截至2021年10月以英文报道并发表的针对人类受试者的随机对照试验。使用改良的Downs和Black质量评估工具进行质量评估。数据采用叙述综合法提取。结果在我们的系统综述中纳入了22篇文章(17篇报道了产妇结局,2篇报道了新生儿结局,3篇报道了两者)。母体研究报告了硒补充剂在预防甲状腺功能障碍、妊娠期糖尿病、妊娠高血压/先兆子痫、氧化应激、产后抑郁、胎膜早破、宫内生长迟缓、母乳成分和HIV阳性妇女方面的作用。新生儿研究报告了母亲补充硒对HIV阳性母亲的胎儿氧化应激、胎儿脂质状况、新生儿高胆红素血症和新生儿结局的影响。大多数研究的设计不恰当,目的是建立临床或科学实用性。令人感兴趣的是,四项研究报告称,硒补充剂通过降低甲状腺过氧化物酶和甲状腺球蛋白抗体滴度,降低了产后甲状腺功能障碍和永久性甲状腺功能减退的发生率。结论支持妊娠期补充硒的证据不足,在推荐常规使用硒之前,需要进行适当设计的随机对照试验。
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引用次数: 6
Lipoprotein Levels in Early Adulthood and NAFLD in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study 成年早期脂蛋白水平和中年NAFLD:青年人冠状动脉风险发展(CARDIA)研究
IF 2.2 Q3 NUTRITION & DIETETICS Pub Date : 2022-04-14 DOI: 10.1155/2022/1727711
S. Khanna, J. Wilkins, Hongyan Ning, N. Allen, C. Lewis, J. Carr, D. Lloyd-Jones, L. VanWagner
Objective We evaluated the association of apolipoprotein B (apoB) with low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and triglycerides (TG) in early adulthood with concordant/discordant associations and midlife NAFLD. Methods Participants from the CARDIA study were included (n = 2,655; baseline mean age: 25.0, 59.1% female, and 48.6% black). NAFLD was defined as liver attenuation ≤40 Hounsfield units after excluding other causes of liver fat. Logistic regression models assessed the odds of Y25 NAFLD among tertiles of apoB, LDL-C, non-HDL-C, and TG and quartiles of the apoB/TG ratio. Discordance/concordance analyses examined the association of apoB with each lipid marker and Y25 NAFLD. Results The Y25 NAFLD prevalence was 10%. The high-tertile TG group (OR 1.87, 95% CI, and 1.30–2.69) and the low- (OR 1.98, 95% CI, and 1.30–3.01) and middle-apoB/TG ratio groups (OR 1.78, 95% CI, and 1.17–2.72) had the greatest odds of midlife NAFLD. Using discordance/concordance analysis, the high-apoB/high-TG group had the highest odds of NAFLD (OR 1.69, 95% CI, and 1.09–2.61) followed by the low-apoB/high-TG group. The high apoB/low TG group had the lowest odds of NAFLD. Conclusions Among the studied lipid markers in early adulthood, TG levels have the strongest and most consistent association with midlife NAFLD.
目的评估载脂蛋白B (apoB)与成年早期低密度脂蛋白胆固醇(LDL-C)、非高密度脂蛋白胆固醇(non-HDL-C)和甘油三酯(TG)的关系,是否与中年NAFLD存在一致性/非一致性关联。方法纳入CARDIA研究的参与者(n = 2,655;基线平均年龄:25.0岁,女性59.1%,黑人48.6%)。在排除其他肝脏脂肪原因后,NAFLD定义为肝脏衰减≤40 Hounsfield单位。Logistic回归模型评估了载脂蛋白ob、LDL-C、非hdl - c和TG的四分位数和载脂蛋白ob /TG的四分位数中Y25 NAFLD的几率。不一致/一致分析检查载脂蛋白ob与每个脂质标志物和Y25 NAFLD的关系。结果Y25 NAFLD患病率为10%。高位数TG组(OR 1.87, 95% CI, 1.30-2.69)、低位数apob /TG组(OR 1.98, 95% CI, 1.30-3.01)和中等位数apob /TG组(OR 1.78, 95% CI, 1.17-2.72)发生中年NAFLD的几率最大。采用不一致/一致性分析,高载脂蛋白/高tg组NAFLD的发生率最高(OR 1.69, 95% CI和1.09-2.61),其次是低载脂蛋白/高tg组。高载脂蛋白/低TG组NAFLD的发生率最低。结论在研究的成年早期脂质标志物中,TG水平与中年NAFLD的相关性最强且最一致。
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引用次数: 0
Examining the Effect of Consuming C8 Medium-Chain Triglyceride Oil for 14 Days on Markers of NLRP3 Activation in Healthy Humans 健康人食用C8中链甘油三酯油14天对NLRP3激活标志物的影响
IF 2.2 Q3 NUTRITION & DIETETICS Pub Date : 2022-04-06 DOI: 10.1155/2022/7672759
Helena Neudorf, Garett S. Jackson, Jonathan P. Little
Chronic, low-grade inflammation is associated with the development of numerous diseases and is mediated in part by overactivation of the NLRP3 inflammasome. The ketone body beta-hydroxybutyrate (βHB) suppresses the NLRP3 inflammasome and alters intracellular signalling pathways in vitro and in animal models; however, this effect has not yet been shown in vivo in humans. The purpose of this single-arm pilot trial was to determine if consuming 15 mL of C8 medium-chain triglyceride (trioctanoin; MCT) oil, which induces mild elevation of βHB, twice daily (30 mL total) for 14 days would suppress markers of NLRP3 inflammasome activation in young, healthy humans while following their habitual diet. Consuming a single dose of 15 mL of C8 MCT oil significantly raised blood βHB from fasting at 60 minutes and 120 minutes post ingestion (both P < 0.05). However, consumption of C8 MCT oil for 14 days did not impact markers of monocyte NLRP3 inflammasome activation compared to baseline. Specifically, caspase-1 activation and secretion of its downstream product interleukin (IL)-1β were unchanged following 14 days of C8 MCT oil supplementation when measured in unstimulated and LPS-stimulated whole blood cultures (all P > 0.05). Acetylation of histone H3 on the lysine residue 9 was unchanged (P < 0.05) and acetylation of lysine residue 14 was decreased (P < 0.05) following 14 days of supplementation. Thus, adding twice daily C8 MCT oil supplementation to the habitual diet of young, healthy humans does not appear to suppress NLRP3 inflammasome activation.
慢性低度炎症与多种疾病的发展有关,部分由NLRP3炎症小体的过度激活介导。酮体β-羟基丁酸(βHB)在体外和动物模型中抑制NLRP3炎症小体并改变细胞内信号通路;然而,这种作用尚未在人体内显示出来。这项单臂试点试验的目的是确定是否消耗15 每日两次(30 mL总量)14天将抑制年轻健康人在遵循其习惯性饮食的同时NLRP3炎症小体激活的标志物。单次服用15 在摄入后60分钟和120分钟禁食时,mL C8 MCT油显著提高血液βHB(均P<0.05)。然而,与基线相比,食用C8 MCT油14天并没有影响单核细胞NLRP3炎症小体激活的标志物。明确地在未刺激和LPS刺激的全血培养中,补充C8-MCT油14天后,胱天蛋白酶-1的激活及其下游产物白细胞介素(IL)-1β的分泌没有变化(均P>0.05)补充。因此,在年轻健康人的习惯性饮食中每天补充两次C8-MCT油似乎不会抑制NLRP3炎症小体的激活。
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引用次数: 1
Knowledge, Consumption Pattern, and Adverse Effects of Energy Drinks among Asian Population: A Cross-Sectional Analysis from Malaysia 亚洲人群能量饮料的知识、消费模式和不良影响——来自马来西亚的横断面分析
IF 2.2 Q3 NUTRITION & DIETETICS Pub Date : 2022-04-06 DOI: 10.1155/2022/3928717
A. H. Mohammed, A. Blebil, Amutha Selvaraj, Zoena Jia Xuan Ang, Cui Yee Chong, Veronica Rui Sim Chu, Yi Qi Ku, Bassam Abdul Rasool Hassan, Abdulrasool M. Wayyes, Abdelhaleem Mustafa Madani
Background The frequent expansion of the energy drinks (EDs) market has caused an extensive increase in the consumption of EDs, especially among younger populations. However, the lack of knowledge on EDs and their perceived beneficial effects could lead to excessive EDs consumption, which is strongly associated with serious side effects. This study aimed to assess the knowledge and perceived beneficial effects of EDs consumers and determine the consumption patterns and side effects experienced by different EDs consumers among the Malaysian population. Methods A descriptive cross-sectional study was conducted in Malaysia from February to April 2021. A structured and validated questionnaire, consisting of 5 sections with 46 items, was distributed online. Only 515 out of 591 invited participants agreed to participate in the study. Descriptive and inferential analysis were done using SPSS. Results The median age of participants was 23 ± 7.3 years. The majority of participants (65%) were unaware of the active ingredients of EDs, and approximately 40% of them had no idea that EDs contain caffeine. The main reason for consuming EDs was to stay awake (43%), and Red Bull was the most preferred brand (57%). Lack of rest (57%), headache (53%), and nervousness (49%) were the most experienced side effects. A significant difference was observed between consumption patterns and knowledge and perceived beneficial effects (p < 0.05). Our data showed a significant association between respondents' demographic data (e.g., coffee intake, smoking, and alcohol status) and their consumption pattern. Conclusion ED consumers in Malaysia were found to have limited knowledge on EDs. Therefore, attention should be drawn to the Ministry of Health regarding the significant side effects such as palpitation and nervousness experienced by ED consumers. Hence, awareness ought to be raised by adopting regulations or policies to regulate the sales and warning labels of EDs in Malaysia.
背景能量饮料市场的频繁扩张导致能量饮料的消费量大幅增加,尤其是在年轻人群中。然而,由于缺乏对ED及其感知到的有益作用的了解,可能会导致过量食用ED,这与严重的副作用密切相关。本研究旨在评估ED消费者的知识和感知的有益效果,并确定马来西亚人群中不同ED消费者的消费模式和副作用。方法2021年2月至4月在马来西亚进行描述性横断面研究。在线分发了一份经过结构化和验证的问卷,由5个部分组成,共46项。591名受邀参与者中只有515人同意参与这项研究。采用SPSS软件进行描述性和推理性分析。结果参与者的中位年龄为23岁 ± 7.3年。大多数参与者(65%)不知道ED的活性成分,其中约40%的人不知道ED含有咖啡因。服用ED的主要原因是保持清醒(43%),红牛是最受欢迎的品牌(57%)。缺乏休息(57%)、头痛(53%)和紧张(49%)是最常见的副作用。消费模式、知识和感知的有益效果之间存在显著差异(p<0.05)。我们的数据显示,受访者的人口统计数据(如咖啡摄入量、吸烟和酒精状况)与其消费模式之间存在显著关联。结论马来西亚ED消费者对ED的了解有限。因此,应注意ED消费者所经历的心悸和紧张等严重副作用。因此,应该通过制定法规或政策来规范马来西亚ED的销售和警告标签,从而提高人们的认识。
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引用次数: 4
Dietary Patterns and Their Association with Metabolic Syndrome and Their Components in Middle-Class Adults from Damascus, Syria: A Cross-Sectional Study 叙利亚大马士革中产阶级成年人的饮食模式及其与代谢综合征及其成分的关系:一项横断面研究
IF 2.2 Q3 NUTRITION & DIETETICS Pub Date : 2022-03-24 DOI: 10.1155/2022/5621701
Malda Atasi, A. Kammar-García, Rafael Almendra-Pegueros, A. R. Navarro-Cruz
Prior to the 2016 crisis in Syria, a study conducted in Aleppo found the prevalence of metabolic syndrome to be 39.6%, which is known to be favoured by age and poor lifestyle (including physical inactivity and the consumption of hypercaloric foods, rich in saturated fats, concentrated carbohydrates, and salt), so the objective of this study was to identify the association of different dietary patterns with metabolic syndrome and their components. A cross-sectional analytical study was carried out in 104 adults aged 40 to 65 years who did not suffer from previous diseases. The sample was chosen from middle-class citizens of the city of Damascus who were contacted by telephone; they were explained about the study, the information that would be collected, and the studies that should be carried out in the clinical analysis laboratory of the Private University of Syria. A nutritional and food study was carried out using previously validated forms containing 62 items in which the food intake of the participants was studied. We apply principal component analysis and factor analysis to detect nutritional components and dietary patterns. Dietary pattern 3 (foods with simple carbohydrates and saturated fat) increased glucose levels, while dietary patterns 1 (high intake of calories, protein, and saturated fat) and 5 (fast food) increased serum triglyceride levels. In addition, pattern 1 (carbonated beverages, grains, chicken, and meat) was associated with elevated LDL cholesterol levels and the presence of the metabolic syndrome. The study findings suggest that the presence of metabolic syndrome and its components are associated with dietary patterns high in calories, protein, simple carbohydrates, and saturated fat.
在2016年叙利亚危机之前,在阿勒颇进行的一项研究发现,代谢综合征的患病率为39.6%,众所周知,年龄和不良生活方式(包括缺乏身体活动和食用富含饱和脂肪、浓缩碳水化合物和盐的高热量食物)是代谢综合征的发病原因,因此本研究的目的是确定不同饮食模式与代谢综合征及其组成部分的关系。一项横断面分析研究对104名年龄在40至65岁之间、既往无疾病的成年人进行了研究。样本选自大马士革市的中产阶级公民,他们通过电话联系;向他们解释了这项研究、将要收集的信息以及应该在叙利亚私立大学临床分析实验室进行的研究。一项营养和食物研究是使用先前验证的表格进行的,表格中包含62项,其中研究了参与者的食物摄入量。我们应用主成分分析和因子分析来检测营养成分和饮食模式。饮食模式3(含简单碳水化合物和饱和脂肪的食物)会增加葡萄糖水平,而饮食模式1(高热量、蛋白质和饱和脂肪的摄入)和饮食模式5(快餐)会增加血清甘油三酯水平。此外,模式1(碳酸饮料、谷物、鸡肉和肉类)与低密度脂蛋白胆固醇水平升高和代谢综合征的出现有关。研究结果表明,代谢综合征及其组成部分的存在与高热量、高蛋白质、高碳水化合物和高饱和脂肪的饮食模式有关。
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引用次数: 2
Dietary Regimen, Overweight, and Obesity in Human Nutrition Students and Other Majors: A Cross-Sectional Study 人类营养学及其他专业学生的饮食习惯、超重与肥胖:一项横断面研究
IF 2.2 Q3 NUTRITION & DIETETICS Pub Date : 2022-03-23 DOI: 10.1155/2022/9957690
Fernando D. Solís-Guevara, Percy G. Ruiz Mamani, J. Saintila
Background Choosing a healthy diet is an increasingly a challenge for university students. The objective of this study was to compare diet and overweight/obesity in human nutrition students (HNS) and students of other careers (SOC) from a university located in Lima, Peru. Methods It was a cross-sectional study consisting of 158 students out of an initial sample of 170. Information was collected on the sociodemographic and anthropometric characteristics of the participants and a validated questionnaire was applied to evaluate the frequency of food consumption. Results There was no significant difference in diet between HNS and SOC (p > 0.05). HNS most frequently consumed yellow/orange vegetables (p = 0.020), purple vegetables (p = 0.049), citrus fruits (p = 0.029), eggs (p = 0.002), whole milk (p = 0.013), yogurt (p = 0.017), tofu (p = 0.003), olive oil (p = 0.003), other vegetable oils (p < 0.001), and alcoholic beverages (p = 0.037) than SOC. In contrast, HNS had a lower frequency of nonfried tuber intake (p = 0.039), fried tubers (p < 0.001), milk desserts (p = 0.048), flour fritters (p = 0.027), cookies with chocolate (p = 0.050), croissants (p = 0.030), cookies with filling (p = 0.024), candies (p = 0.006), and soda (p = 0.016) than SOC. Overweight/obesity was not different between HNS and SOC (p > 0.05). Conclusions This study found significant differences in the consumption of some foods between HNS and SOC. However, it found no significant difference in diet and overweight/obesity between HNS and SOC.
背景选择健康饮食对大学生来说是一个越来越大的挑战。本研究的目的是比较秘鲁利马一所大学人类营养专业学生(HNS)和其他职业学生(SOC)的饮食和超重/肥胖情况。方法这是一项横断面研究,由170名初始样本中的158名学生组成。收集了参与者的社会人口统计和人体测量特征信息,并使用经验证的问卷来评估食物消费频率。结果HNS组与SOC组在饮食方面差异无统计学意义(p > HNS最常食用黄色/橙色蔬菜(p = 0.020),紫色蔬菜(p = 0.049),柑橘类水果(p = 0.029),鸡蛋(p = 0.002),全脂牛奶(p = 0.013)、酸奶(p = 0.017)、豆腐(p = 0.003)、橄榄油(p = 0.003)、其他植物油(p  0.05)。结论本研究发现,HNS和SOC在某些食物的消费方面存在显著差异。然而,HNS与SOC在饮食和超重/肥胖方面没有显著差异。
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引用次数: 1
Corrigendum to “Food Expenditure and Food Consumption before and during Ramadan in Moroccan Households” “摩洛哥家庭斋月前和斋月期间的粮食支出和粮食消费”的勘误表
IF 2.2 Q3 NUTRITION & DIETETICS Pub Date : 2022-03-18 DOI: 10.1155/2022/9839623
Imane Barakat, Hamid Chamlal, Sanaa El Jamal, Mohammed Elayachi, R. Belahsen
[This corrects the article DOI: 10.1155/2020/8849832.].
[这更正了文章DOI:10.1155/2020/8849832.]。
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引用次数: 0
Possible Beneficial Effects of Fresh Pomegranate Juice in SARS-CoV-2 Infection Conditions 新鲜石榴汁在SARS-CoV-2感染条件下可能的有益作用
IF 2.2 Q3 NUTRITION & DIETETICS Pub Date : 2022-03-05 DOI: 10.1155/2022/5134560
S. Banihani
Rather than the prophylactic vaccination, any effective synthetic, natural, or nutritional therapy or regimen that may cure or remedy, albeit partially, the complications of SARS-CoV-2 should be highly acknowledged. Here, we reviewed and discussed possible beneficial biological effects of pomegranate juice in such diseased condition of viral infection based on the current published evidence (direct and indirect) and owing to the robust evidence that fresh pomegranate juice is highly rich with unique bioactive compounds that are approved in various occasions to be effective in several chronic diseased conditions. All related references that serve our aim are accessed through available electronic databases, particularly PubMed and Scopus. In summary, there is accepted evidence that pomegranate juice may be beneficial in SARS-CoV-2 infection conditions, especially for patients with the clinical history of chronic diseases such as hypertension, cardiovascular disease, diabetes, and cancer. However, the interventional studies that directly probe and confirm the effectiveness of fresh pomegranate juice in the management of SARS-CoV-2 infection are mandatory.
与预防性疫苗接种不同,任何有效的合成、天然或营养疗法或方案都应该得到高度认可,这些疗法或方案可能治愈或补救严重急性呼吸系统综合征冠状病毒2型的并发症,尽管是部分的。在这里基于目前已发表的证据(直接和间接),以及新鲜石榴汁富含独特的生物活性化合物的有力证据,我们回顾和讨论了石榴汁在病毒感染的疾病条件下可能产生的有益生物效应,这些化合物在各种场合被批准对几种慢性疾病有效。所有符合我们目标的相关参考文献都可以通过可用的电子数据库访问,特别是PubMed和Scopus。总之,有公认的证据表明,石榴汁可能对严重急性呼吸系统综合征冠状病毒2型感染有益,尤其是对有高血压、心血管疾病、糖尿病和癌症等慢性病临床病史的患者。然而,直接探索和证实新鲜石榴汁在治疗严重急性呼吸系统综合征冠状病毒2型感染中的有效性的干预研究是强制性的。
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引用次数: 3
The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery 甲状旁腺激素对减肥手术后非酒精性脂肪肝的预测作用
IF 2.2 Q3 NUTRITION & DIETETICS Pub Date : 2022-02-28 DOI: 10.1155/2022/7319742
T. Jamialahmadi, M. Nematy, M. Abdalla, A. Jangjoo, L. Goshayeshi, M. Kroh, S. Moallem, M. Abbasifard, T. Sathyapalan, A. Sahebkar
Background Morbid obesity is frequently complicated by chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and fibrosis. Parathyroid hormone (PTH) is found to be elevated in morbid obesity due to the defective hepatic metabolism of vitamin D. Bariatric surgery is performed to help patients with BMI>40 kg/m2 to effectively lose weight, particularly in patients with obesity who are afflicted with complications such as NAFLD/NASH. Objective This study aimed to evaluate the PTH level as a predictor of hepatic function in individuals with morbid obesity who have undergone bariatric surgery. Methods Ninety subjects with morbid obesity referred for Roux en-Y gastric bypass surgery were recruited. After IRB approval, demographic profiles, anthropometric factors, liver biopsy, and laboratory tests were obtained. The two-dimensional shear wave elastography (2D-SWE) technique was applied to assess hepatic stiffness. Results A significant reduction occurred six months after bariatric surgery in the anthropometric indices (p < 0.001), hepatic elasticity (p=0.002), alanine aminotransferase (p < 0.001), serum alkaline phosphatase (p < 0.001), gamma-glutamyl transpeptidase (GGT) (p < 0.001), and nonalcoholic fatty liver disease fibrosis score (NFS) (p < 0.001). Serum PTH concentration was not predictive of postsurgical liver fibrosis and steatosis at six months but could predict weight loss success rate. No significant alteration in serum PTH levels was observed between presurgical vs. postsurgical time points. Conclusion A significant reduction was observed in the anthropometric parameters, liver enzymes, and hepatic elasticity after bariatric surgery. No significant effect was found on PTH levels.
背景病态肥胖经常并发慢性肝病,包括非酒精性脂肪性肝病(NAFLD)、非酒精性脂性肝炎(NASH)和纤维化。由于维生素D的肝脏代谢缺陷,甲状旁腺激素(PTH)在病态肥胖中升高。为了帮助BMI>40的患者,进行了减肥手术 kg/m2有效减肥,特别是在患有NAFLD/NASH等并发症的肥胖患者中。目的本研究旨在评估PTH水平作为接受减肥手术的病态肥胖患者肝功能的预测指标。方法选择90例接受Roux-en-Y胃旁路手术的病态肥胖患者。在IRB批准后,获得了人口统计学特征、人体测量因素、肝活检和实验室测试。应用二维剪切波弹性成像(2D-SWE)技术评估肝脏硬度。结果减肥手术后6个月,人体测量指标(p<0.001)、肝脏弹性(p=0.002)、丙氨酸氨基转移酶(p<0.01)、血清碱性磷酸酶(p<001)、γ-谷氨酰转肽酶(GGT)(p<0.05)、,血清PTH浓度不能预测术后6个月的肝纤维化和脂肪变性,但可以预测减肥成功率。术前与术后时间点之间未观察到血清PTH水平的显著变化。结论减肥手术后人体测量参数、肝酶和肝弹性显著降低。PTH水平无明显影响。
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引用次数: 1
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Journal of Nutrition and Metabolism
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