Journal of Ovarian Research最新文献

英文中文

The efficacy and safety of Cangfu Daotan decoction in the treatment of infertility associated with polycystic ovary syndrome: a systematic review and meta-analysis. 苍妇导痰汤治疗多囊卵巢综合征不孕症的疗效和安全性：系统综述和meta分析。

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research

Pub Date : 2026-02-06 DOI: 10.1186/s13048-026-02008-x

Qingling Xie, Yi Wang, Yumei Tang, Jili Xu, Lijie Yang, Jie Wu

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by ovulatory dysfunction and hormonal imbalance, often leading to infertility. Cangfu Daotan Decoction (CFDTT, Atractylodis Rhizoma, Cyperi Rhizoma, Pinelliae Rhizoma, Poria, Pericarpium Citri Reticulatae, Glycyrrhizae Radix et Rhizoma, Arisaema cum Bile, Aurantii Fructus) is a traditional Chinese herbal formula commonly used to treat PCOS-related infertility, with its pathogenesis attributed to phlegm-dampness obstruction. There is an urgent need for a systematic evaluation of its efficacy and safety.Objective: To evaluate the efficacy, safety, and potential mechanisms of CFDTT in treating PCOS-related infertility, providing evidence for clinical application and future research.Methods: Seven databases were searched to identify randomized controlled trials (RCTs) evaluating CFDTT for PCOS-related infertility. Data were analyzed using meta-analysis, subgroup analysis, sensitivity analysis, publication bias testing (funnel plot, Egger's test, trimming and filling method), and evidence quality assessment (GRADE).Results: A total of 19 RCTs involving 2,181 participants were identified. CFDTT combined with conventional pharmacotherapy was superior to conventional pharmacotherapy alone in improving ovulation rate, pregnancy rate, ovarian volume, dominant follicle count, and endometrial thickness. However, due to high heterogeneity and methodological limitations, the overall certainty of the evidence was low to very low. Only two trials directly compared CFDTT with conventional pharmacotherapy, reporting no significant differences in pregnancy rate or endometrial thickness, but the evidence was limited to a single study. Safety data are inadequately reported: 73.7% of trials did not provide information on adverse events, and laboratory monitoring data are scarce. Existing evidence suggests that CFDTT does not increase the risk of adverse events and may reduce the risk of ovarian hyperstimulation syndrome (OHSS) or luteinized unruptured follicle syndrome (LUFS), but organ toxicity cannot be ruled out. Publication bias exists for some outcomes, but sensitivity analyses confirmed the robustness of key findings.Conclusion: This meta-analysis provides preliminary evidence supporting the use of CFDTT as an adjunctive therapy for infertility associated with PCOS, suggesting potential synergistic effects when combined with conventional pharmacotherapy. While the efficacy of CFDTT monotherapy appears comparable to that of conventional pharmacotherapy, the available evidence remains highly limited. However, the included studies exhibit substantial methodological shortcomings, including a high risk of bias, considerable heterogeneity, and significant gaps in safety monitoring. Consequently, the current findings regarding the efficacy and safety of CFDTT should

背景：多囊卵巢综合征（PCOS）是一种常见的内分泌疾病，以排卵功能障碍和激素失调为特征，常导致不孕。苍术导痰汤（苍术、香附、半夏、茯苓、枸橼皮、甘草、莪术、枳壳）是治疗pcos相关性不孕症的传统中药方剂，其病机以痰湿梗阻为主。迫切需要对其有效性和安全性进行系统评价。目的：评价CFDTT治疗pcos相关性不孕症的疗效、安全性及潜在机制，为临床应用及未来研究提供依据。方法：检索7个数据库，以确定评估CFDTT治疗pcos相关不孕症的随机对照试验（rct）。采用meta分析、亚组分析、敏感性分析、发表偏倚检验（漏斗图、Egger检验、修剪填充法）和证据质量评价（GRADE）对数据进行分析。结果：共纳入19项随机对照试验，涉及2181名受试者。CFDTT联合常规药物治疗在提高排卵率、妊娠率、卵巢体积、优势卵泡计数、子宫内膜厚度等方面均优于常规药物治疗。然而，由于高度异质性和方法学上的限制，证据的总体确定性低至非常低。只有两项试验直接比较了CFDTT与常规药物治疗，报告在妊娠率或子宫内膜厚度方面没有显著差异，但证据仅限于单一研究。安全性数据报告不充分：73.7%的试验没有提供不良事件信息，实验室监测数据很少。现有证据表明，CFDTT不会增加不良事件的风险，并可能降低卵巢过度刺激综合征（OHSS）或黄体化未破裂卵泡综合征（LUFS）的风险，但不能排除器官毒性。一些结果存在发表偏倚，但敏感性分析证实了关键发现的稳健性。结论：本荟萃分析提供了初步证据，支持使用CFDTT作为PCOS相关不孕症的辅助治疗，表明与常规药物治疗联合可能产生协同效应。虽然CFDTT单药治疗的疗效似乎与传统药物治疗相当，但现有证据仍然非常有限。然而，纳入的研究显示出大量的方法学缺陷，包括高偏倚风险、相当大的异质性和安全监测方面的重大差距。因此，目前有关CFDTT疗效和安全性的研究结果应谨慎解读，通过精心设计的、大规模的前瞻性随机对照试验进一步验证是证实这些结果的必要条件。系统评价注册：https://www.crd.york.ac.uk/PROSPERO/recorddashboard临床试验注册：由于本研究是荟萃分析而不是临床试验，因此不需要在临床试验注册中心注册。

{"title":"The efficacy and safety of Cangfu Daotan decoction in the treatment of infertility associated with polycystic ovary syndrome: a systematic review and meta-analysis.","authors":"Qingling Xie, Yi Wang, Yumei Tang, Jili Xu, Lijie Yang, Jie Wu","doi":"10.1186/s13048-026-02008-x","DOIUrl":"https://doi.org/10.1186/s13048-026-02008-x","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by ovulatory dysfunction and hormonal imbalance, often leading to infertility. Cangfu Daotan Decoction (CFDTT, Atractylodis Rhizoma, Cyperi Rhizoma, Pinelliae Rhizoma, Poria, Pericarpium Citri Reticulatae, Glycyrrhizae Radix et Rhizoma, Arisaema cum Bile, Aurantii Fructus) is a traditional Chinese herbal formula commonly used to treat PCOS-related infertility, with its pathogenesis attributed to phlegm-dampness obstruction. There is an urgent need for a systematic evaluation of its efficacy and safety.Objective: To evaluate the efficacy, safety, and potential mechanisms of CFDTT in treating PCOS-related infertility, providing evidence for clinical application and future research.Methods: Seven databases were searched to identify randomized controlled trials (RCTs) evaluating CFDTT for PCOS-related infertility. Data were analyzed using meta-analysis, subgroup analysis, sensitivity analysis, publication bias testing (funnel plot, Egger's test, trimming and filling method), and evidence quality assessment (GRADE).Results: A total of 19 RCTs involving 2,181 participants were identified. CFDTT combined with conventional pharmacotherapy was superior to conventional pharmacotherapy alone in improving ovulation rate, pregnancy rate, ovarian volume, dominant follicle count, and endometrial thickness. However, due to high heterogeneity and methodological limitations, the overall certainty of the evidence was low to very low. Only two trials directly compared CFDTT with conventional pharmacotherapy, reporting no significant differences in pregnancy rate or endometrial thickness, but the evidence was limited to a single study. Safety data are inadequately reported: 73.7% of trials did not provide information on adverse events, and laboratory monitoring data are scarce. Existing evidence suggests that CFDTT does not increase the risk of adverse events and may reduce the risk of ovarian hyperstimulation syndrome (OHSS) or luteinized unruptured follicle syndrome (LUFS), but organ toxicity cannot be ruled out. Publication bias exists for some outcomes, but sensitivity analyses confirmed the robustness of key findings.Conclusion: This meta-analysis provides preliminary evidence supporting the use of CFDTT as an adjunctive therapy for infertility associated with PCOS, suggesting potential synergistic effects when combined with conventional pharmacotherapy. While the efficacy of CFDTT monotherapy appears comparable to that of conventional pharmacotherapy, the available evidence remains highly limited. However, the included studies exhibit substantial methodological shortcomings, including a high risk of bias, considerable heterogeneity, and significant gaps in safety monitoring. Consequently, the current findings regarding the efficacy and safety of CFDTT should ","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review of the emerging role of NRF3 in ovarian cancer tumorigenesis and progression. NRF3在卵巢癌发生发展中的作用综述

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research

Pub Date : 2026-02-06 DOI: 10.1186/s13048-026-01987-1

Mahdi Hosseinzadeh, Abbas Karimi, Mohsen Rashid, Mohammad Reza Sadegi

引用次数: 0

Repurposing trifluoperazine as a potential therapeutic agent for ovarian cancer: mechanistic insight via SRC/PI3K/AKT signaling pathway inhibition. 重新利用三氟拉嗪作为卵巢癌的潜在治疗剂：通过SRC/PI3K/AKT信号通路抑制的机制

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research

Pub Date : 2026-02-04 DOI: 10.1186/s13048-026-01966-6

Quan He, Jiaqi Mei, Desheng Cai, Qinghua Yan, Yanping Zhang, Yuting Deng, Wenyan Li, Jiaying Xiong, Junhui Wan, Yuanqiao He

引用次数: 0

Role of immune cells in clear cell ovarian cancer: a two-sample bidirectional Mendelian randomization study. 免疫细胞在透明细胞卵巢癌中的作用：一项双样本双向孟德尔随机研究

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research

Pub Date : 2026-02-04 DOI: 10.1186/s13048-026-02001-4

Qinan Xian, Juan Zhou, Xin Li, Yiwen Xu, Yan Sun

Background: Recent investigations reported an association between clear cell ovarian cancer(CCOC) and abnormal immune regulation, but the causal relationship among this association and specific immune cell the features needs further elucidation. The aim of the research conducted had been to investigate the potential causal impact of immune cell traits on CCOC applying a bivariate example Mendelian randomization(MR) journey.

Methods: We gathered genome-wide association study (GWAS) data on 731 categories of immunological cells and clear cell ovarian cancer from the currently published literature. To find the genetic associations between various immune cell traits and the risk of clear cell ovarian cancer, we employed inverse variance weighting (IVW) as the primary analysis technique and carried out sensitivity analyses to confirm the accuracy of the findings.

Results: This study found that six immune features were associated with an increased risk of clear cell ovarian cancer, including various T-cell and B-cell markers. The results of reverse MR analysis show that clear cell ovarian cancer can lower the level of CD3 on CD39 + resting Treg. Sensitivity analysis showed no heterogeneity or level-dependent pleiotropy.

Conclusion: This study reveals the possible genetic connected among immunophenotype and the danger of CCOC, providing new genetic ideas for understanding the connection with immune cells and clear cell ovarian cancer, while providing theoretical support for exploring the pathogenesis and immunotherapy of CCOC.

背景：最近的研究报道了透明细胞卵巢癌（CCOC）与异常免疫调节之间的关联，但这种关联与特异性免疫细胞特征之间的因果关系有待进一步阐明。所进行的研究的目的是应用双变量孟德尔随机化（MR）过程来调查免疫细胞性状对CCOC的潜在因果影响。方法：我们从目前发表的文献中收集了731种免疫细胞和透明细胞卵巢癌的全基因组关联研究（GWAS）数据。为了寻找各种免疫细胞性状与透明细胞卵巢癌风险之间的遗传关联，我们采用逆方差加权（IVW）作为主要分析技术，并进行敏感性分析以确认结果的准确性。结果：该研究发现6种免疫特征与透明细胞卵巢癌的风险增加有关，包括各种t细胞和b细胞标记物。反向MR分析结果显示，透明细胞卵巢癌可降低CD39 +静息Treg上CD3的水平。敏感性分析显示无异质性或水平依赖性多效性。结论：本研究揭示了免疫表型与CCOC危险性之间可能存在的遗传联系，为理解其与免疫细胞、透明细胞卵巢癌的联系提供了新的遗传学思路，同时为探索CCOC的发病机制和免疫治疗提供了理论支持。

{"title":"Role of immune cells in clear cell ovarian cancer: a two-sample bidirectional Mendelian randomization study.","authors":"Qinan Xian, Juan Zhou, Xin Li, Yiwen Xu, Yan Sun","doi":"10.1186/s13048-026-02001-4","DOIUrl":"https://doi.org/10.1186/s13048-026-02001-4","url":null,"abstract":"Background: Recent investigations reported an association between clear cell ovarian cancer(CCOC) and abnormal immune regulation, but the causal relationship among this association and specific immune cell the features needs further elucidation. The aim of the research conducted had been to investigate the potential causal impact of immune cell traits on CCOC applying a bivariate example Mendelian randomization(MR) journey.Methods: We gathered genome-wide association study (GWAS) data on 731 categories of immunological cells and clear cell ovarian cancer from the currently published literature. To find the genetic associations between various immune cell traits and the risk of clear cell ovarian cancer, we employed inverse variance weighting (IVW) as the primary analysis technique and carried out sensitivity analyses to confirm the accuracy of the findings.Results: This study found that six immune features were associated with an increased risk of clear cell ovarian cancer, including various T-cell and B-cell markers. The results of reverse MR analysis show that clear cell ovarian cancer can lower the level of CD3 on CD39 + resting Treg. Sensitivity analysis showed no heterogeneity or level-dependent pleiotropy.Conclusion: This study reveals the possible genetic connected among immunophenotype and the danger of CCOC, providing new genetic ideas for understanding the connection with immune cells and clear cell ovarian cancer, while providing theoretical support for exploring the pathogenesis and immunotherapy of CCOC.","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anastomotic leakage after rectosigmoid resection with primary anastomosis during cytoreductive surgery for advanced high-grade serous ovarian cancer: risk factors and oncologic outcomes. 晚期高级别浆液性卵巢癌细胞减缩术中直肠乙状结肠切除术与一期吻合术后吻合口漏：危险因素和肿瘤预后

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research

Pub Date : 2026-02-03 DOI: 10.1186/s13048-026-02003-2

Arife Ebru Tasci, Fatih Kılıç, Mehmet Ünsal, Okan Aytekin, Yeşim Özkaya Uçar, Gülşah Tiryaki Güner, Burak Ersak, Ayşe Buran, İbrahim Ethem Canbulut, Caner Çakır, Sevgi Koç, Nurettin Boran, Özlem Moraloğlu Tekin, Yaprak Üstün, Ahmet Taner Turan

引用次数: 0

Mesenchymal stem cell therapy for premature ovarian insufficiency: progress and challenges. 间充质干细胞治疗卵巢早衰：进展和挑战。

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research

Pub Date : 2026-02-03 DOI: 10.1186/s13048-026-01976-4

Zhuyan Shao, Leilei Liang, Yite Xue, Tao Zhu, Qiang Wen

引用次数: 0

Indole-3-carbinol alleviates cisplatin-induced ovarian damage by inhibiting ovarian fibrosis through the TGF-β1/Smad pathway. 吲哚-3-甲醇通过TGF-β1/Smad途径抑制卵巢纤维化，减轻顺铂诱导的卵巢损伤。

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research

Pub Date : 2026-02-03 DOI: 10.1186/s13048-026-01994-2

Fengyu Zhu, Fangfang Li, Ruixin Zhang, Zhuoying He, Jiaoyu Li, Nie Zhang, Hongxu Chen, Jiaqi Chen, Linghui Cheng, Fei Zhong

引用次数: 0

Serum long noncoding RNA FAM83H-AS1 serves as a potential noninvasive diagnostic biomarker for ovarian cancer. 血清长链非编码RNA FAM83H-AS1可作为卵巢癌潜在的无创诊断生物标志物。

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research

Pub Date : 2026-02-03 DOI: 10.1186/s13048-026-01995-1

Chunying Tian, Hongshuai Sun, Ruiyao Li, Yuanyuan Chen, Ting Li, Xiaoming Su, Xiuyan Yu

引用次数: 0

Mechanistic insights into EOC-PMCs-Induced macrophage polarization via the Galnt15-PPARγ pathway. 通过Galnt15-PPARγ途径了解eoc - pmcs诱导巨噬细胞极化的机制。

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research

Pub Date : 2026-02-02 DOI: 10.1186/s13048-026-02002-3

Shuangge Liu, Huachi Li, Xiaoduan Li

Background: Ascites represents an extremely unique liquid immunosuppressive microenvironment of epithelial ovarian cancer (EOC), and it contains a substantial quantity of macrophages; however, these macrophages fail to exhibit effective anti-tumor activity. Peritoneal mesothelial cells (PMCs) constitute a critical component of ascites. Whether PMCs can modulate macrophages function through some mechanisms, thereby influencing the tumor immune microenvironment, remains to be elucidated.

Methods: Co-culture models of EOC-educated PMCs (EOC-PMCs) and macrophages in human and mouse were respectively constructed, and verified the differences of polarization markers, cytokines, and metabolic levels in macrophages after co-culture. Transcriptional sequencing experiments confirmed that polypeptide N-acetylgalactosaminyltransferase 15 (Galnt15) was highly expressed in macrophages after co-culture. Nuclear-cytoplasmic protein separation and immunofluorescence (IF) were used to confirm that the nuclear entry of peroxisome proliferator-activated receptor γ (PPARγ) increased and the polarization of macrophages was enhanced when Galnt15 was overexpressed. In vitro experiments, the overexpression and knockdown of Galnt15 were achieved using plasmids and siRNAs. Immunoprecipitation (IP) experiments verified that high expression of Galnt15 mediated the O-glycosylation of PPARγ, thereby affecting the nuclear entry of PPARγ. Site mutation and fusion protein detection were employed to explore the functional site of Galnt15-mediated O-glycosylation of the PPARγ protein. And an EOC model in situ was established on the ovary of C57BL/6J, and it was confirmed in vivo and in vitro that macrophages treated with EOC-PMCs played a pro-cancer role. Tissue microarrays confirmed that the expression of Galnt15 and PPARγ was related to patient prognosis.

Results: EOC-PMCs led to high expression of Galnt15 in macrophages. Galnt15 promoted O-glycosylation and nuclear translocation of PPARγ, subsequently enhancing fatty acid oxidation (FAO) metabolism, and inducing macrophages polarization and secretion of pro-tumor cytokines. Animal experiments showed that EOC-PMCs increased the FAO metabolism level of macrophages to promote tumor development. Tissue microarray also confirmed that there was a positive correlation between the expression of Galnt15 and PPARγ, and patients with high expression of Galnt15/PPARγ had a poorer prognosis.

Conclusion: EOC-PMCs promote macrophages polarization through the Galnt15/PPARγ pathway, which is conducive to the formation of an immunosuppressive microenvironment in ascites and ultimately facilitates the progression of ovarian cancer.

背景：腹水是上皮性卵巢癌（EOC）极其独特的液体免疫抑制微环境，其中含有大量巨噬细胞；然而，这些巨噬细胞没有表现出有效的抗肿瘤活性。腹膜间皮细胞（PMCs）是腹水的重要组成部分。PMCs是否通过某种机制调节巨噬细胞功能，从而影响肿瘤免疫微环境，尚不清楚。方法：分别构建人、小鼠EOC-PMCs与巨噬细胞共培养模型，验证共培养后巨噬细胞极化标记物、细胞因子及代谢水平的差异。转录测序实验证实，共培养后巨噬细胞中高表达了多肽n -乙酰半乳糖氨基转移酶15 （Galnt15）。核细胞质蛋白分离和免疫荧光（IF）证实，当Galnt15过表达时，过氧化物酶体增殖激活受体γ (PPARγ)的核进入增加，巨噬细胞的极化增强。在体外实验中，利用质粒和sirna实现了Galnt15的过表达和低表达。免疫沉淀（IP）实验证实Galnt15的高表达介导了PPARγ的o糖基化，从而影响了PPARγ的核进入。利用位点突变和融合蛋白检测来探索galnt15介导的PPARγ蛋白o糖基化的功能位点。并在C57BL/6J卵巢上原位建立EOC模型，体内外均证实经EOC- pmcs处理的巨噬细胞具有促癌作用。组织微阵列证实Galnt15和PPARγ的表达与患者预后有关。结果：EOC-PMCs导致巨噬细胞中Galnt15的高表达。Galnt15促进PPARγ的o-糖基化和核易位，从而增强脂肪酸氧化（FAO）代谢，诱导巨噬细胞极化和促肿瘤细胞因子的分泌。动物实验表明，eoc - pmc可提高巨噬细胞的FAO代谢水平，促进肿瘤的发生发展。组织芯片也证实Galnt15与PPARγ的表达呈正相关，Galnt15/PPARγ高表达的患者预后较差。结论：EOC-PMCs通过Galnt15/PPARγ通路促进巨噬细胞极化，有利于腹水形成免疫抑制微环境，最终促进卵巢癌的进展。

{"title":"Mechanistic insights into EOC-PMCs-Induced macrophage polarization via the Galnt15-PPARγ pathway.","authors":"Shuangge Liu, Huachi Li, Xiaoduan Li","doi":"10.1186/s13048-026-02002-3","DOIUrl":"https://doi.org/10.1186/s13048-026-02002-3","url":null,"abstract":"Background: Ascites represents an extremely unique liquid immunosuppressive microenvironment of epithelial ovarian cancer (EOC), and it contains a substantial quantity of macrophages; however, these macrophages fail to exhibit effective anti-tumor activity. Peritoneal mesothelial cells (PMCs) constitute a critical component of ascites. Whether PMCs can modulate macrophages function through some mechanisms, thereby influencing the tumor immune microenvironment, remains to be elucidated.Methods: Co-culture models of EOC-educated PMCs (EOC-PMCs) and macrophages in human and mouse were respectively constructed, and verified the differences of polarization markers, cytokines, and metabolic levels in macrophages after co-culture. Transcriptional sequencing experiments confirmed that polypeptide N-acetylgalactosaminyltransferase 15 (Galnt15) was highly expressed in macrophages after co-culture. Nuclear-cytoplasmic protein separation and immunofluorescence (IF) were used to confirm that the nuclear entry of peroxisome proliferator-activated receptor γ (PPARγ) increased and the polarization of macrophages was enhanced when Galnt15 was overexpressed. In vitro experiments, the overexpression and knockdown of Galnt15 were achieved using plasmids and siRNAs. Immunoprecipitation (IP) experiments verified that high expression of Galnt15 mediated the O-glycosylation of PPARγ, thereby affecting the nuclear entry of PPARγ. Site mutation and fusion protein detection were employed to explore the functional site of Galnt15-mediated O-glycosylation of the PPARγ protein. And an EOC model in situ was established on the ovary of C57BL/6J, and it was confirmed in vivo and in vitro that macrophages treated with EOC-PMCs played a pro-cancer role. Tissue microarrays confirmed that the expression of Galnt15 and PPARγ was related to patient prognosis.Results: EOC-PMCs led to high expression of Galnt15 in macrophages. Galnt15 promoted O-glycosylation and nuclear translocation of PPARγ, subsequently enhancing fatty acid oxidation (FAO) metabolism, and inducing macrophages polarization and secretion of pro-tumor cytokines. Animal experiments showed that EOC-PMCs increased the FAO metabolism level of macrophages to promote tumor development. Tissue microarray also confirmed that there was a positive correlation between the expression of Galnt15 and PPARγ, and patients with high expression of Galnt15/PPARγ had a poorer prognosis.Conclusion: EOC-PMCs promote macrophages polarization through the Galnt15/PPARγ pathway, which is conducive to the formation of an immunosuppressive microenvironment in ascites and ultimately facilitates the progression of ovarian cancer.","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative efficacy of human chorionic gonadotropin alone versus dual trigger for oocyte maturation in advanced maternal age using the antagonist protocol: a randomized controlled trial. 使用拮抗剂方案的人绒毛膜促性腺激素单独与双重触发对高龄产妇卵母细胞成熟的比较疗效：一项随机对照试验。

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research

Pub Date : 2026-01-31 DOI: 10.1186/s13048-026-01993-3

Isarin Thanaboonyawat, Kittidech Phukittiwarangkul, Pattraporn Chera-Aree, Pitak Laokirkkiat

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Journal of Ovarian Research

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀