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Phytochemical Screening and Comparative Anthelmintic Activity of Psidium guajava L. Leaves extract against Pheretima posthuma 番石榴叶提取物的植物化学筛选及对柱状假脱机的比较杀虫活性
Pub Date : 2021-09-15 DOI: 10.18579/jopcr/v20i3.ms21042
D. K. Pradhan, M. Mishra, Abhishek Hota
Objective: Psidium guajava L. (Family: Myrtaceae.), commonly known as Guava, is a well-known traditional medicinal plant used in treatment of vomiting, diarrhea, dysentery, flatulence, gastroenteritis, abdominal distention and hyperglycemia. The present study was carried out to evaluate Phytochemical and Comparative in vitro anthelmintic activity of P. guajava leave extracts against Indian adult earthworm Pheretima posthuma . Methods: The traditional medicinal plant is used to control gastrointestinal infections. The phytochemical analysis and anthelmintic effects of extracts (Chloform, aqueous & methanol) and the standard drug (Piperazine citrate) were tested against Indian adult earthworm. The time taken to paralyze and death time of earthworm was considered for anthelmintic effects. Results: The phytochemical analysis revealed the presence of flavanoids, glycosides, alkaloids, steroids, and tannins. Methanolic extract of P. guajava leave extract was showed significant anthelmintic activity among all extracts. Methanolic extract havebeenfoundthehighestrateofparalysis(1.820 (cid:6) 0.242min)anddeath(5.573 (cid:6) 0.315min)ofearthworm againstthestandarddrugPiperazinecitrate.Conclusion:Thewormicidalactivityof P.guajava leavesextract suggests that it could be effective against parasitic infections of humans and validate the traditional use of P. guajava as a natural therapy for treatment of anthelmintic infection.
目的:番石榴(Psidium guajava L.,科:杨梅科),俗称番石榴,是一种著名的传统药用植物,用于治疗呕吐、腹泻、痢疾、胀气、肠胃炎、腹胀和高血糖。本研究旨在评价番石榴叶提取物对印度成年蚯蚓Pheretima posthuma的植物化学和体外比较驱虫活性。方法:采用中药植物防治胃肠道感染。以印度成年蚯蚓为试材,对其提取物(氯仿、水溶液和甲醇)和标准药物(柠檬酸哌嗪)进行了植物化学分析和驱虫效果测试。蚯蚓麻痹时间和死亡时间是考虑驱虫效果的因素。结果:植物化学分析结果表明,黄烷类、糖苷类、生物碱类、甾体类和单宁类化合物的存在。番石榴叶提取物的甲醇提取物在所有提取物中表现出显著的驱虫活性。结果表明,番石榴叶提取物具有较高的杀虫活性(1.820(cid:6)0.242min)和致死率(5.573(cid:6)0.315min)传染
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引用次数: 0
Prevalence of Micro and Macrovascular Complications and Assessment of Risk Factors in Diabetic patients: a Prospective Observational Study 糖尿病患者微血管和大血管并发症患病率及危险因素评估:一项前瞻性观察研究
Pub Date : 2021-09-15 DOI: 10.18579/jopcr/v20i3.ms21056
D. Jothieswari, R. M. Soniya, R. S. Vinuthna, P. Venkatesh, V. Hari
Diabetes is a chronic metabolic disorder of heterogenous type. Diabetic complications are mostly associated with condition of vascular penetrability that affects different tissues & kidneys, retina, nerves which involve the body organs.The aim of study was to assess the prevalence of micro and macro diabetic complications and risk factors of diabetic patients. The prospective observational study was conducted in Raghu Diabetes and general clinic, Chittoor, Andhra Pradesh. A sample size of 200 subjects was recruited for the study. The study was conducted from December 2020 to May 2021. Patients with age group of 30-90 years and diabetic complications were included in the study. Patients below 30 years of age were excluded from study. The patient details were collected using questionnaire form. It contains sociodemographic data and medical history including smoking, alcohol, family history of diabetes mellitus, and treatment and management of diabetes. The statistical analysis was carried out using SPSS version 25.0. The study results showed 1.5% of patients had more than two co-morbidities, which was significantly higher among elderly (5.04%), females (5.2%) and urban residence (6.31%), physical inactivity (3.15%) and house wife (2.1%). The statins prescribed patients were 160 (80%) whereas patients on other medications, insulin in combination with OHA38(19%),andmultivitaminsprescribedpatients181(90.5%).Thestudyshowedthepatient’sageof51-70yearswasmostlyaffectedbydiabetes.Regularexercise,intakeofmorevegetablesandfruitsandadoptingahealthierlife-stylecanreducetheprevalenceofdiabetes.
糖尿病是一种异质性慢性代谢性疾病。糖尿病并发症主要与影响不同组织的血管穿透性状况有关,包括肾脏、视网膜、涉及身体器官的神经。本研究旨在了解糖尿病患者宏观、微观并发症的发生率及危险因素。前瞻性观察研究在安得拉邦Chittoor的Raghu糖尿病和普通诊所进行。该研究招募了200名受试者作为样本。该研究于2020年12月至2021年5月进行。研究对象为年龄在30-90岁之间且伴有糖尿病并发症的患者。年龄小于30岁的患者被排除在研究之外。采用问卷形式收集患者详细信息。它包含社会人口统计数据和病史,包括吸烟、饮酒、糖尿病家族史以及糖尿病的治疗和管理。采用SPSS 25.0版本进行统计分析。研究结果显示,1.5%的患者有两种以上的合并症,其中老年人(5.04%)、女性(5.2%)、城市居民(6.31%)、缺乏运动(3.15%)和家庭主妇(2.1%)的合并症比例最高。服用他汀类药物的患者为160例(80%),而服用其他药物的患者,胰岛素联合OHA38(19%),服用多种维生素的患者为181例(90.5%)。研究表明51-70岁的患者主要受糖尿病影响,有规律的运动,摄入更多的蔬菜和水果,采取更健康的生活方式可以降低糖尿病的患病率。
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引用次数: 0
A Study on the Knowledge and Attitude of the Ayurvedic and Dental Undergraduates of Central India towards ACLS and BLS 印度中部阿育吠陀和牙科本科生对ACLS和BLS的知识和态度研究
Pub Date : 2021-09-14 DOI: 10.9734/JPRI/2021/V33I43B32569
Anjali Bankar, Amit Reche, K. Chhabra, P. Madhu, Mehek Batra, Radhika kannake, Ramani Mandale
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引用次数: 0
Occurrence of Hemorrhoids and Anal Fissures through Pregnancy and Postpartum 妊娠和产后痔疮和肛裂的发生
Pub Date : 2021-09-07 DOI: 10.9734/JPRI/2021/V33I43A32497
Esmatullah, Baseera
Objective: To recognize occurrence also danger issues of hemorrhoids and fissures throughout pregnancy and afterwards childbirth. Population: The overall 180 pregnant females trailed up till 1 month after delivery. Methods: Females remained inspected 4 times via pregnancy and after delivery; those that developed perianal diseases were compared with those that did not. Main outcome measures Incidence, time and risk factors of hemorrhoids and fissures. Our current research was done in Nangarhar Reginal Hospital Gyn/ Obs ward from June -2020 to June -2021.  Results: In total 90 (50%) female patients have developed perineal diseases (Hemorrhoid, Anal Fissure. The most vulnerable times were 3rd trimester about 60 (66.6%), Second trimester 20(22.2%) and in the first month after deliver 10(11.11%). From these Patients Investigation shows that 65(72.2%) only suffering from hemorrhoid and 15(13.5%) has both hemorrhoid and anal fissure. 80 female undergone Vaginal delivery and 10 remind has undergone of caesarean section. Risk Factors for Perineal illness during pregnancy was Constipation, Straining throughout delivery for more than 20 mins and baby weight >3900gr. Conclusions: Hemorrhoids and fissures remain mutual throughout last trimester of pregnancy and one month afterwards delivery, through constipation, individual past of hemorrhoids or fissures, birth weight of new >3900 g, straining throughout delivery for extra than 20 mins being self-sufficiently related risk factors.
目的:了解痔疮和裂在整个妊娠期和产后的发生和危险问题。人口:总共180名孕妇一直待到产后1个月。方法:雌性在妊娠期和产后进行4次检查;将那些发生肛周疾病的人与那些没有发生的人进行比较。主要观察指标痔疮和裂的发生率、时间和危险因素。我们目前的研究于2020年6月至2021年6月在楠格哈尔地区医院Gyn/Obs病房进行。结果:总共有90名(50%)女性患者出现了会阴疾病(痔疮、肛裂。最脆弱的时期是孕晚期,约60名(66.6%),妊娠中期20例(22.2%),产后第一个月10例(11.11%)。调查显示,65例(72.2%)仅患有痔疮,15例(13.5%)同时患有痔疮和肛裂。其中80例为阴道分娩,10例为剖宫产。妊娠期患会阴疾病的风险因素是便秘、分娩过程中压力超过20分钟以及婴儿体重>3900克。结论:痔疮和裂隙在整个妊娠晚期和分娩后一个月内一直相互存在,主要是由于便秘、个人痔疮或裂隙病史、新生儿体重>3900克、分娩过程中超过20分钟的紧张是自我充分相关的危险因素。
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引用次数: 0
Evaluation of Antioxidant Property of Moringa Oleifera Leaves and its Effectiveness Against Rheumatoid Arthritis 辣木叶抗氧化性能及其对类风湿性关节炎的疗效评价
Pub Date : 2021-08-23 DOI: 10.9734/JPRI/2021/V33I41B32358
M. J. Kapil, D. Deka, M. Lahkar, N. Sharma
The present study is performed with the purpose of evaluating the antioxidant nature of Moringa Oleifera leaves and the effectiveness of the leaf extract against the disease called Rheumatoid Arthritis. The disease is very chronic and it is a common disease. So the study is focused on the medicinal properties of Moringa Oleifera leaves, chemical composition of Moringa Oleifera leaves and seeds, the antioxidant nature of moringa leaves and its extracts, the effectiveness of moringa leaf extract against the Rheumatoid Arthritis disease, reason behind the effectiveness of moringa leaves and discussion and analysis of the result generated.
本研究的目的是评估辣木叶的抗氧化性质和叶提取物对类风湿性关节炎的有效性。这种病很慢性,是一种常见病。因此,本研究的重点是辣木叶的药用特性、辣木叶和种子的化学成分、辣木叶子及其提取物的抗氧化性、辣木树叶提取物对类风湿性关节炎的有效性、辣树叶子有效性背后的原因以及对结果的讨论和分析。
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引用次数: 2
Effects of Solvents and Extraction Methods on Naringenin, LC-MS Based Quantitative Studies and Major Metabolite of Cochlospermum gossypium 溶剂和提取方法对棉蚜Naringenin、LC-MS定量研究及主要代谢产物的影响
Pub Date : 2021-08-23 DOI: 10.9734/JPRI/2021/V33I41B32361
Y. Rajendra, K. Sunitha
Aim: The present study was aimed to investigate “Effects of Solvents and Extraction Methods on Naringenin, LC-MS Based Quantitative Studies and major Metabolite of Cochlospermum Gossypium”. Study Design: LC-MS based Quantification Studies. Place and Duration of Study: Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, Visakhapatnam, Andhra Pradesh between April 2019 and July 2020. Methodology: Rapid and Quantitative efficient extraction methods were used by using soxhlet and Ultrasound mediated extraction techniques for a range of polar solvents and Isolation of Naringenin by gradient elution technique, In the present study Naringenin was isolated in abundance (1%) by repetitive chromatographic purifications of the ethyl acetate extract of the bark part of C.gossypium. In view of high therapeutic potential, detailed HPLC based quantitative studies was carried out on C. gossypium bark, which contains significant levels of Naringenin. Results: The chromatographic separation was performed on the stationary phase, based on different retention mechanisms due to hydrophilic and hydrophobic interactions between compounds and stationary phase. In total, 24 different polar extracts were generated by soxhlet and ultrasound extraction methods from the two bark samples which were collected from Jaipur town (Telangana state) and Trichur town (Kerala state). Conclusion: The highest Naringenin content (0.59%) was found in the methanol + chloroform (1:1) extract (E8) generated by direct Soxhlet extraction of C.gossypium bark collected from Jaipur (Telangana state).Naringenin was isolated from a non-citrus plant for first time from Cochlospermum gosspyium and more significantly it is isolated in large quantity. It was obtained in 99.9% purity as shown by LCMS.
目的:研究“溶剂和提取方法对纳灵菌素的影响,基于LC-MS的定量研究及Cochlospermum Gossypium的主要代谢产物”。研究设计:基于LC-MS的定量研究。学习地点和时间:2019年4月至2020年7月,安得拉邦维萨卡帕特南GITAM药学研究所药物化学系。方法:对一系列极性溶剂采用索氏和超声介导的提取技术,采用梯度洗脱技术分离Naringenin,在本研究中,通过重复色谱纯化棉蚜树皮部分的乙酸乙酯提取物,分离出大量(1%)的纳林宁。鉴于其高治疗潜力,对含有大量纳林宁的棉蚜树皮进行了详细的基于HPLC的定量研究。结果:由于化合物与固定相之间的亲水和疏水相互作用,基于不同的保留机制,在固定相上进行了色谱分离。从斋浦尔镇(特伦甘纳州)和特里库尔镇(喀拉拉邦)采集的两个树皮样本中,通过索氏提取法和超声波提取法总共产生了24种不同的极性提取物。结论:从斋浦尔(特伦甘纳州)棉蚜皮中直接索氏提取得到的甲醇+氯仿(1:1)提取物(E8)中纳林根素含量最高(0.59%),是首次从非柑橘类植物中分离到纳林根蛋白,且分离量较大。其以99.9%的纯度获得,如LCMS所示。
{"title":"Effects of Solvents and Extraction Methods on Naringenin, LC-MS Based Quantitative Studies and Major Metabolite of Cochlospermum gossypium","authors":"Y. Rajendra, K. Sunitha","doi":"10.9734/JPRI/2021/V33I41B32361","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I41B32361","url":null,"abstract":"Aim: The present study was aimed to investigate “Effects of Solvents and Extraction Methods on Naringenin, LC-MS Based Quantitative Studies and major Metabolite of Cochlospermum Gossypium”. \u0000Study Design: LC-MS based Quantification Studies. \u0000Place and Duration of Study: Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, Visakhapatnam, Andhra Pradesh between April 2019 and July 2020. \u0000Methodology: Rapid and Quantitative efficient extraction methods were used by using soxhlet and Ultrasound mediated extraction techniques for a range of polar solvents and Isolation of Naringenin by gradient elution technique, In the present study Naringenin was isolated in abundance (1%) by repetitive chromatographic purifications of the ethyl acetate extract of the bark part of C.gossypium. In view of high therapeutic potential, detailed HPLC based quantitative studies was carried out on C. gossypium bark, which contains significant levels of Naringenin. \u0000Results: The chromatographic separation was performed on the stationary phase, based on different retention mechanisms due to hydrophilic and hydrophobic interactions between compounds and stationary phase. In total, 24 different polar extracts were generated by soxhlet and ultrasound extraction methods from the two bark samples which were collected from Jaipur town (Telangana state) and Trichur town (Kerala state). \u0000Conclusion: The highest Naringenin content (0.59%) was found in the methanol + chloroform (1:1) extract (E8) generated by direct Soxhlet extraction of C.gossypium bark collected from Jaipur (Telangana state).Naringenin was isolated from a non-citrus plant for first time from Cochlospermum gosspyium and more significantly it is isolated in large quantity. It was obtained in 99.9% purity as shown by LCMS.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"217-228"},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44038847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Metformin in Pediatric Type-1 Diabetes Mellitus in Addition to Insulin Therapy; Literature Review 二甲双胍与胰岛素治疗对儿童1型糖尿病的影响文献综述
Pub Date : 2021-08-23 DOI: 10.9734/JPRI/2021/V33I41B32357
Mohammed Abdullah Alzahimah, Khalid Mohammed S. Al Sleem, Hatem Ahmed Albenawy, Albara Abdullah Mohammed Al Mushham
{"title":"The Impact of Metformin in Pediatric Type-1 Diabetes Mellitus in Addition to Insulin Therapy; Literature Review","authors":"Mohammed Abdullah Alzahimah, Khalid Mohammed S. Al Sleem, Hatem Ahmed Albenawy, Albara Abdullah Mohammed Al Mushham","doi":"10.9734/JPRI/2021/V33I41B32357","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I41B32357","url":null,"abstract":"","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"187-192"},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43957988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies of Serum Calcium, Inorganic Phosphate and Magnesium Levels in Lactating Mothers in Owerri Owerri哺乳期母亲血清钙、无机磷和镁水平的研究
Pub Date : 2021-08-23 DOI: 10.9734/JPRI/2021/V33I41B32360
A. Edward, E. Obeagu, H. Okorie, C. Vincent, Yakubu Sunday Bot
{"title":"Studies of Serum Calcium, Inorganic Phosphate and Magnesium Levels in Lactating Mothers in Owerri","authors":"A. Edward, E. Obeagu, H. Okorie, C. Vincent, Yakubu Sunday Bot","doi":"10.9734/JPRI/2021/V33I41B32360","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I41B32360","url":null,"abstract":"","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"209-216"},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46937093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Comparative Analysis of Differentially Expressed Genes in Oral Leukoplakia and Oral Submucous Fibrosis Using Bioinformatics Approach 应用生物信息学方法比较分析口腔白斑和口腔黏膜下纤维化差异表达基因
Pub Date : 2021-08-23 DOI: 10.9734/JPRI/2021/V33I41B32356
Akansha Budakoti, C. More, A. Seth, Priyanka Sharma
{"title":"Comparative Analysis of Differentially Expressed Genes in Oral Leukoplakia and Oral Submucous Fibrosis Using Bioinformatics Approach","authors":"Akansha Budakoti, C. More, A. Seth, Priyanka Sharma","doi":"10.9734/JPRI/2021/V33I41B32356","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I41B32356","url":null,"abstract":"","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"177-186"},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43845011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review On: Nutraceuticals Challenges in Formulation and Its Regulatory Aspects 营养保健品在配方和监管方面的挑战综述
Pub Date : 2021-07-12 DOI: 10.33140/jpr.06.02.01
Nutraceuticals have sparked great attention because of their perceived safety, The current article focuses on the need for appropriate diets, health issues associated with failure to adhere to the known healthy eating models, development of new nutraceuticals/functional foods/food supplements with novel health benefits, elucidation mechanisms of action of these products, and to define and understand the analytical, challenges during the formulation of different dosage form, current scenario in India, future and regulatory aspects of nutraceuticals. the Indian industry and regulatory scenario are relatively nascent and have great potential to develop and compete with other international agencies. This is a rapidly growing industry in India and several initiatives have been taken in this direction to make India one of the key future players in the area of nutraceuticals. This article can help you stay up to date on the latest advancements in nutraceutical research.
营养保健品因其公认的安全性而引起了极大的关注,本文主要关注适当饮食的必要性,与未遵循已知健康饮食模式相关的健康问题,具有新型健康益处的新营养保健品/功能食品/食品补充剂的开发,阐明这些产品的作用机制,并定义和理解不同剂型配方中的分析挑战。印度目前的情况,营养药品的未来和监管方面。印度的工业和监管情况相对较新,具有很大的发展潜力并与其他国际机构竞争。这是印度一个快速增长的行业,在这个方向上已经采取了一些举措,使印度成为营养保健领域未来的关键参与者之一。这篇文章可以帮助你跟上营养研究的最新进展。
{"title":"A Review On: Nutraceuticals Challenges in Formulation and Its Regulatory Aspects","authors":"","doi":"10.33140/jpr.06.02.01","DOIUrl":"https://doi.org/10.33140/jpr.06.02.01","url":null,"abstract":"Nutraceuticals have sparked great attention because of their perceived safety, The current article focuses on the need for appropriate diets, health issues associated with failure to adhere to the known healthy eating models, development of new nutraceuticals/functional foods/food supplements with novel health benefits, elucidation mechanisms of action of these products, and to define and understand the analytical, challenges during the formulation of different dosage form, current scenario in India, future and regulatory aspects of nutraceuticals. the Indian industry and regulatory scenario are relatively nascent and have great potential to develop and compete with other international agencies. This is a rapidly growing industry in India and several initiatives have been taken in this direction to make India one of the key future players in the area of nutraceuticals. This article can help you stay up to date on the latest advancements in nutraceutical research.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44184777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Pharmaceutical Research
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