{"title":"Simultaneous Estimation of Stigmasterol and Lupeol in Adenanthera pavonina using HPTLC Method","authors":"Fachara Bhagyashri, M. Chhabria","doi":"10.18579/jopcr/v21i3.1","DOIUrl":"https://doi.org/10.18579/jopcr/v21i3.1","url":null,"abstract":"","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49252486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adverse Drug Reaction Profiling of Antidiabetics, Antianginals and Antibiotics based on Hospital Survey","authors":"Sk Md Khalid, Mayukh K Sarkar","doi":"10.18579/jopcr/v21i3.2","DOIUrl":"https://doi.org/10.18579/jopcr/v21i3.2","url":null,"abstract":"","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42212962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Survey of Healthcare Professionals Attitude and Awareness towards Quick Response Codes and Review of its Possible Applications in Medical Education and Pharmaceutical Industry","authors":"Varun Pareek, Shivangi Sharma, Susheel Kumar, Abhinav Pareek, Lokendra Sharma, Rajveer Singh Rathore","doi":"10.18579/jopcr/v21i3.3","DOIUrl":"https://doi.org/10.18579/jopcr/v21i3.3","url":null,"abstract":"","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47964070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shailin Dkhar, E. Akila, V. N. Swamy, N. Pruthvi
In the present research, the Histological examination, physiological evaluation, phytochemical screening, total phenolic content and total flavonoid content and TLC of leaf extracts of Chenopodium giganteum have been studied. Ethanol, aqueous, chloroform, and pet ether extracts of Chenopodium giganteum was prepared. Phytochemical screening shows presence of carbohydrates, proteins, amino acids, glycosides like saponin and flavonoids, tannins, phenols, alkaloids, and steroids. The physiological evaluation shows total ash 15.12% w/w and acid insoluble ash value 7.46%w/w, loss of drying was found to be 8.1% w/w, extractive value of pet ether extract was found to be 2.3% w/w, chloroform extract 4.5% w/w, ethanol extract 7.2% w/w and water 10.2% w/w. The total flavonoid content of pet ether extract was found to be 17.2227±0.0729 µg/ml, chloroform extract 23.7224±0.0878 µg/ml, ethanol extract 49.8601±0.0303 µg/ml and water extract 64.7705±0.0375 µg/ml. The total phenolic content of pet ether extract was found to be 14.477±0.0226 µg/ml, chloroform extract 17.764±0.0216 µg/ml, ethanol extract 19.518±0.0173 µg/ml and water extract 27.686±0.0233 µg/ml. TLC of pet ether extract shows constituents having Rf values 0.548, 0.274, 0.1935, and 0.080, chloroform extract shows constituents having Rf values 0.765, 0.656, 0.468, 0.234, and 0.156, ethanol extract shows constituents having Rf values 0.815 and 0.584, and water extract shows constituents having Rf values 0.704 and 0.064. Keywords: Histological examination, physiological evaluation, phytochemical screening, Chenopodium giganteum
{"title":"Scientific Standardization of Various Extracts of Chenopodium giganteum D. Leaves","authors":"Shailin Dkhar, E. Akila, V. N. Swamy, N. Pruthvi","doi":"10.18579/jopcr/v21i2.3","DOIUrl":"https://doi.org/10.18579/jopcr/v21i2.3","url":null,"abstract":"In the present research, the Histological examination, physiological evaluation, phytochemical screening, total phenolic content and total flavonoid content and TLC of leaf extracts of Chenopodium giganteum have been studied. Ethanol, aqueous, chloroform, and pet ether extracts of Chenopodium giganteum was prepared. Phytochemical screening shows presence of carbohydrates, proteins, amino acids, glycosides like saponin and flavonoids, tannins, phenols, alkaloids, and steroids. The physiological evaluation shows total ash 15.12% w/w and acid insoluble ash value 7.46%w/w, loss of drying was found to be 8.1% w/w, extractive value of pet ether extract was found to be 2.3% w/w, chloroform extract 4.5% w/w, ethanol extract 7.2% w/w and water 10.2% w/w. The total flavonoid content of pet ether extract was found to be 17.2227±0.0729 µg/ml, chloroform extract 23.7224±0.0878 µg/ml, ethanol extract 49.8601±0.0303 µg/ml and water extract 64.7705±0.0375 µg/ml. The total phenolic content of pet ether extract was found to be 14.477±0.0226 µg/ml, chloroform extract 17.764±0.0216 µg/ml, ethanol extract 19.518±0.0173 µg/ml and water extract 27.686±0.0233 µg/ml. TLC of pet ether extract shows constituents having Rf values 0.548, 0.274, 0.1935, and 0.080, chloroform extract shows constituents having Rf values 0.765, 0.656, 0.468, 0.234, and 0.156, ethanol extract shows constituents having Rf values 0.815 and 0.584, and water extract shows constituents having Rf values 0.704 and 0.064. Keywords: Histological examination, physiological evaluation, phytochemical screening, Chenopodium giganteum","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46469704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The number of women with osteoporosis, a condition characterized with reduced bone mass and the disruption of bone architecture is on the rise in India. Deficiency of calcium and low vitamin D levels are important risk factors for the development of osteoporosis. Low sun exposure, inadequate dietary vitamin D intake, lack of food fortification with vitamin D, pigmented skin, environmental pollution, and traditional dress code further aggravate the condition. Age, gender (female), Asian origin, low BMI also act as a threat for the disorder. It is estimated that maximum bone loss occurs in women during perimenopause and menopause, indicating the prevalence of osteoporosis to increase with advancing age, resulting in a geriatric female population prone to fractures and related morbidities. For the proper management of any disorder, it is imperative that the patient should have an understanding of the disease, which begins with awareness. However, owing to societal pressures the elderly Indian female population rarely prioritizes osteoporosis as a major health issue. In the last few decades the life expectancy has increased giving rise to a larger geriatric population. It is necessary to ensure proper health status for this populace, in order to improve their quality of life which will uplift the national health benchmark. The key to effective and compliant therapy is adequate knowledge of the disorder among the target subjects. The current review highlights the prevalence, etiology and awareness of osteoporosis among Indian women. Keywords: Osteoporosis, Indian women, Awareness
{"title":"Osteoporosis — Are we aware?","authors":"Sen Suchandra, Mookerjee Musfiqua","doi":"10.18579/jopcr/v21i2.1","DOIUrl":"https://doi.org/10.18579/jopcr/v21i2.1","url":null,"abstract":"The number of women with osteoporosis, a condition characterized with reduced bone mass and the disruption of bone architecture is on the rise in India. Deficiency of calcium and low vitamin D levels are important risk factors for the development of osteoporosis. Low sun exposure, inadequate dietary vitamin D intake, lack of food fortification with vitamin D, pigmented skin, environmental pollution, and traditional dress code further aggravate the condition. Age, gender (female), Asian origin, low BMI also act as a threat for the disorder. It is estimated that maximum bone loss occurs in women during perimenopause and menopause, indicating the prevalence of osteoporosis to increase with advancing age, resulting in a geriatric female population prone to fractures and related morbidities. For the proper management of any disorder, it is imperative that the patient should have an understanding of the disease, which begins with awareness. However, owing to societal pressures the elderly Indian female population rarely prioritizes osteoporosis as a major health issue. In the last few decades the life expectancy has increased giving rise to a larger geriatric population. It is necessary to ensure proper health status for this populace, in order to improve their quality of life which will uplift the national health benchmark. The key to effective and compliant therapy is adequate knowledge of the disorder among the target subjects. The current review highlights the prevalence, etiology and awareness of osteoporosis among Indian women. Keywords: Osteoporosis, Indian women, Awareness","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45882590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dostarlimab is a humanised anti-PD-1 immunoglobulin (IgG4) monoclonal antibody (mAb). It has a high affinity for the PD-1 receptor and effectively inhibits interactions with PD-L1 and PD-L2 by blocking their binding to the PD-1 receptor. Programmed cell death 1 (PD-1) is an immunological checkpoint receptor that transmits inhibitory signals to limit local inflammatory responses and preserve self-tolerance. It is found on antigen-activated and fatigued T cells. When the PD-1 receptor binds to the tumor-expressed ligands PD-L1 and PD-L2, T-cell proliferation and cytokine production are suppressed. Keywords: Dostarlimab, PD1 immunoglobulin, T - cell proliferation
{"title":"Pharmacology of Dostarlimab: A Review","authors":"A. Roy, Akash Chaurasiya","doi":"10.18579/jopcr/v21i2.2","DOIUrl":"https://doi.org/10.18579/jopcr/v21i2.2","url":null,"abstract":"Dostarlimab is a humanised anti-PD-1 immunoglobulin (IgG4) monoclonal antibody (mAb). It has a high affinity for the PD-1 receptor and effectively inhibits interactions with PD-L1 and PD-L2 by blocking their binding to the PD-1 receptor. Programmed cell death 1 (PD-1) is an immunological checkpoint receptor that transmits inhibitory signals to limit local inflammatory responses and preserve self-tolerance. It is found on antigen-activated and fatigued T cells. When the PD-1 receptor binds to the tumor-expressed ligands PD-L1 and PD-L2, T-cell proliferation and cytokine production are suppressed. Keywords: Dostarlimab, PD1 immunoglobulin, T - cell proliferation","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45267897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-15DOI: 10.18579/jopcr/v21i1.glucomannan
Sonia Sharma, N. Wadhwa
Glucomannan (GM) a water-soluble polysaccharide possesses mannose residues which are extracted from tubers, bulbs, softwoods and roots of many plants. Glucomannan is considered to be a dietary fibre which is actually present in some plant species in the form of hemicelluloses component in the cell wall. Its structure consists of linear chain of mixed residues of α-1,4 linked D-mannose and D-glucose monomers arranged in blocks. The molecular weight of native GM lies between 1×104– 2×106. Low molecular weight GM could be obtained by de-polymerization technique. The average molecular weight of Konjac Glucomannan (KGM) is 500,000 – 2,000,000 and varies with species, growing area, storage time and processing methods. The glucomannan from different sources vary in its mannose to glucose ratio. Konjac tuber glucomannan has a molar ratio of 1.6:1 or 1.4:1 (ratio differs with konjac breeds), Orchid tubers and Scotch pine have molar ratios of 3.6:1 and 2.1:1 respectively. Diversity of glucomannan also depends on degree of acetylation in GM chain. Values of degree of acetylation are 5to10% or every 19th sugar residue (attached randomly at C-6 position in KGM), is actually responsible to facilitate dispersion and solubility by inhibiting the intra-molecular hydrogen bonds. This solubility function is attractive for multiple pharmaceutical applications. However increase in acetylation degree in GM slows the gelation process. The intrinsic viscosity of KGM solution is highest among the polysaccharides that facilitate swelling behaviour and hence gel formation that finds application in food industry. Gels have good stability, films, hydrogel, beads, micro and nanoparticles of Glucomannan may have potential usage in therapeutic drug delivery systems without causing toxicity. It may also be useful in treatment of chronic constipation, decreasing serum cholesterol, and increasing insulin sensitivity. As a food supplement it could play a significant role in weight loss. Carboxymethylated glucomannan improves the properties of paper, such as burst index, dry tensile index, and wet tensile index. These diverse applications make Glucomannan a most sought after biomolecule. Keywords: Biomolecule, Glucomannan, Diverse application
{"title":"Application of Glucomannan","authors":"Sonia Sharma, N. Wadhwa","doi":"10.18579/jopcr/v21i1.glucomannan","DOIUrl":"https://doi.org/10.18579/jopcr/v21i1.glucomannan","url":null,"abstract":"Glucomannan (GM) a water-soluble polysaccharide possesses mannose residues which are extracted from tubers, bulbs, softwoods and roots of many plants. Glucomannan is considered to be a dietary fibre which is actually present in some plant species in the form of hemicelluloses component in the cell wall. Its structure consists of linear chain of mixed residues of α-1,4 linked D-mannose and D-glucose monomers arranged in blocks. The molecular weight of native GM lies between 1×104– 2×106. Low molecular weight GM could be obtained by de-polymerization technique. The average molecular weight of Konjac Glucomannan (KGM) is 500,000 – 2,000,000 and varies with species, growing area, storage time and processing methods. The glucomannan from different sources vary in its mannose to glucose ratio. Konjac tuber glucomannan has a molar ratio of 1.6:1 or 1.4:1 (ratio differs with konjac breeds), Orchid tubers and Scotch pine have molar ratios of 3.6:1 and 2.1:1 respectively. Diversity of glucomannan also depends on degree of acetylation in GM chain. Values of degree of acetylation are 5to10% or every 19th sugar residue (attached randomly at C-6 position in KGM), is actually responsible to facilitate dispersion and solubility by inhibiting the intra-molecular hydrogen bonds. This solubility function is attractive for multiple pharmaceutical applications. However increase in acetylation degree in GM slows the gelation process. The intrinsic viscosity of KGM solution is highest among the polysaccharides that facilitate swelling behaviour and hence gel formation that finds application in food industry. Gels have good stability, films, hydrogel, beads, micro and nanoparticles of Glucomannan may have potential usage in therapeutic drug delivery systems without causing toxicity. It may also be useful in treatment of chronic constipation, decreasing serum cholesterol, and increasing insulin sensitivity. As a food supplement it could play a significant role in weight loss. Carboxymethylated glucomannan improves the properties of paper, such as burst index, dry tensile index, and wet tensile index. These diverse applications make Glucomannan a most sought after biomolecule. Keywords: Biomolecule, Glucomannan, Diverse application","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42328690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-15DOI: 10.18579/jopcr/v21i1.ms21.78
Nirmala Limarkar, Dipika Chavda, V. Thakkar, T. Gandhi
The present study was aimed to apply quality by design to develop stable and flexible pediatric granules of BCS class II drug Cefiximeto improve dissolution profile using Soluplus®. Thegranules were prepared by employing the wet granulation technique. The concentration of Soluplus®(X1), Croscarmellose sodium(X2), Sodium bicarbonate(X3) were identified as critical material attributes(CMA). The critical quality attribute (CQA) are percentage drug release in 20 minutes (Y1) and dispersion time (Y2). All 17 batches were evaluated for micromeritics properties, drug content, particle size distribution, dispersion time, granules' strength/friability, In vitro drug release, comparison with marketed product and stability study. All 17 batches from the Box Behnken showed all the test results values within limits, indicating that the prepared granules were of standard quality. The optimized batch of granules showed 94.45±0.26% drug release in 20min, while the dispersion time was 90.85±0.04 sec and the similarity factor (f2) was 56.39 to marketed product (ZIPRAX). In addition, the optimized batch exhibited no significant change in drug content, dispersion time, in vitro drug release after storage at 40°C ±2°C and 75% RH ± 5% RH for one month. The formulated granules showed better drug release and dispersion time. The granules can be reconstituted with water to prepare dispersion of the drug just before use to improve compliance of paediatric patients. Keywords: Cefixime, granules, Quality by design, Box Behnken design, Soluplus®, Design space
{"title":"Systematic Formulation Approach for Development and Evaluation of Cefixime G ranules for Pediatric Application","authors":"Nirmala Limarkar, Dipika Chavda, V. Thakkar, T. Gandhi","doi":"10.18579/jopcr/v21i1.ms21.78","DOIUrl":"https://doi.org/10.18579/jopcr/v21i1.ms21.78","url":null,"abstract":"The present study was aimed to apply quality by design to develop stable and flexible pediatric granules of BCS class II drug Cefiximeto improve dissolution profile using Soluplus®. Thegranules were prepared by employing the wet granulation technique. The concentration of Soluplus®(X1), Croscarmellose sodium(X2), Sodium bicarbonate(X3) were identified as critical material attributes(CMA). The critical quality attribute (CQA) are percentage drug release in 20 minutes (Y1) and dispersion time (Y2). All 17 batches were evaluated for micromeritics properties, drug content, particle size distribution, dispersion time, granules' strength/friability, In vitro drug release, comparison with marketed product and stability study. All 17 batches from the Box Behnken showed all the test results values within limits, indicating that the prepared granules were of standard quality. The optimized batch of granules showed 94.45±0.26% drug release in 20min, while the dispersion time was 90.85±0.04 sec and the similarity factor (f2) was 56.39 to marketed product (ZIPRAX). In addition, the optimized batch exhibited no significant change in drug content, dispersion time, in vitro drug release after storage at 40°C ±2°C and 75% RH ± 5% RH for one month. The formulated granules showed better drug release and dispersion time. The granules can be reconstituted with water to prepare dispersion of the drug just before use to improve compliance of paediatric patients. Keywords: Cefixime, granules, Quality by design, Box Behnken design, Soluplus®, Design space","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41556567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-15DOI: 10.18579/jopcr/v21i1.ms22.31
Tharcitus Chilaka Onwudiwe, P. Unekwe, K. C. Chilaka, C. E. Ilo, G. Akuodor, S. K. Mobisson
Despite many etiological factors, gastric acid secretion is assumed to play a central role in the development of gastric ulcer. Blockade of gastric acid secretion therefore, seems to be the key therapeutic objective of gastric ulcer disease. Available acid-blocking/anti-secretory drugs used in the management of gastric ulcer are associated with high cost, unwanted side effects and treatment relapse. Extracts from plants can be useful and may serve as an alternative to conventional drugs in gastric ulcer management. This work was aimed at assessing the gastric acid anti-secretory effects of fractionated ethanol extract of Piper guineense leaf on histamine-induced ulcer in Wistar rats. This was conducted by administering orally, 400mg/kg of fraction extracts obtained by fractionation of ethanol-extracted residue, to fifty six adult Wistar rats randomized into eight groups (n=7) of animals followed by induction of ulcer with 40mg/kg histamine, orally. The effects of the plant extracts on histamine-induced ulcer, gastric pH and gastric volume were ascertained. From the results, all the extracts significantly (p<0.05) produced ulcer inhibition, increased gastric pH and reduced gastric volume. This study concludes that extracts of Piper guineense leaf possess antiulcer effects, which may occur via histamine-2-receptor blockade and/or anti-secretory mediated activities. Keywords: Gastric acid, Fraction extracts, Histamine, Antisecretory, Piper guineense
{"title":"Assessment of Gastric Acid Anti-Secretory Effects of Fraction Extracts of Piper guineense Leaf on Histamine-Induced Gastric Ulcer in Wistar Rats","authors":"Tharcitus Chilaka Onwudiwe, P. Unekwe, K. C. Chilaka, C. E. Ilo, G. Akuodor, S. K. Mobisson","doi":"10.18579/jopcr/v21i1.ms22.31","DOIUrl":"https://doi.org/10.18579/jopcr/v21i1.ms22.31","url":null,"abstract":"Despite many etiological factors, gastric acid secretion is assumed to play a central role in the development of gastric ulcer. Blockade of gastric acid secretion therefore, seems to be the key therapeutic objective of gastric ulcer disease. Available acid-blocking/anti-secretory drugs used in the management of gastric ulcer are associated with high cost, unwanted side effects and treatment relapse. Extracts from plants can be useful and may serve as an alternative to conventional drugs in gastric ulcer management. This work was aimed at assessing the gastric acid anti-secretory effects of fractionated ethanol extract of Piper guineense leaf on histamine-induced ulcer in Wistar rats. This was conducted by administering orally, 400mg/kg of fraction extracts obtained by fractionation of ethanol-extracted residue, to fifty six adult Wistar rats randomized into eight groups (n=7) of animals followed by induction of ulcer with 40mg/kg histamine, orally. The effects of the plant extracts on histamine-induced ulcer, gastric pH and gastric volume were ascertained. From the results, all the extracts significantly (p<0.05) produced ulcer inhibition, increased gastric pH and reduced gastric volume. This study concludes that extracts of Piper guineense leaf possess antiulcer effects, which may occur via histamine-2-receptor blockade and/or anti-secretory mediated activities. Keywords: Gastric acid, Fraction extracts, Histamine, Antisecretory, Piper guineense","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46213885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-15DOI: 10.18579/jopcr/v21i1.ms21.81
N. Choudhary, Dipika Chavda, V. Thakkar, T. Gandhi
This study was aimed to utilize the Moisture Activated Dry Granulation (MADG) technique to formulate Bicalutamide tablet and identify critical factors influencing its dissolution. The Bicalutamide inclusion complex was formed using the kneading method. Aeroperl 300 was selected as an adsorbent, polyvinylpyrrolidone (PVP) K30 as a binder, Microcrystalline Cellulose (MCC) and Lactose Monohydrate (LMH) in1:1 ratio as fillers. Croscarmellose sodium (CCS) and neusilin were used as disintegrating agents, as they did not affect the disintegration time when hardness and compression force increased. Box Behnken experimental design was used to optimize formulations and was evaluated for pre and post-compression parameters. The optimized formulation was compared with the marketed and wet granulation formulation. In addition, the short term stability testing of the optimized batch was performed. The optimized inclusioncomplex of hydroxypropyl beta-cyclodextrin (HP-ß-CD) was selected based on a phase solubility study in 1:1 ratio with drug toimprove solubility. The optimized batch was prepared by MADG at granulator speed of 540rpm, using 4.30 % PVPK30, and 1.5 % Aeroperl 300. It showed a disintegration time of 208.33 sec.Percentage drug release was 95.02 % in 30 mins, and hardness 5.4 kg/cm2. The stability study results confirmed the stability of the tablets. The Bicalutamide tablet was successfully formulated using the MADG technique. The parameters affecting the in-vitro dissolution were identified and optimized, leading to better bioavailability. Keywords: Bicalutamide, Moisture Activated Dry Granulation technology (MADG), hydroxypropyl beta-cyclodextrin (HP-β-CD), Box Behnken design (BBD), Croscarmellose sodium
{"title":"Identification of Critical Factors Influencing the In-Vitro Dissolution o f Bicalutamide Tablets Prepared Using Madg Technique","authors":"N. Choudhary, Dipika Chavda, V. Thakkar, T. Gandhi","doi":"10.18579/jopcr/v21i1.ms21.81","DOIUrl":"https://doi.org/10.18579/jopcr/v21i1.ms21.81","url":null,"abstract":"This study was aimed to utilize the Moisture Activated Dry Granulation (MADG) technique to formulate Bicalutamide tablet and identify critical factors influencing its dissolution. The Bicalutamide inclusion complex was formed using the kneading method. Aeroperl 300 was selected as an adsorbent, polyvinylpyrrolidone (PVP) K30 as a binder, Microcrystalline Cellulose (MCC) and Lactose Monohydrate (LMH) in1:1 ratio as fillers. Croscarmellose sodium (CCS) and neusilin were used as disintegrating agents, as they did not affect the disintegration time when hardness and compression force increased. Box Behnken experimental design was used to optimize formulations and was evaluated for pre and post-compression parameters. The optimized formulation was compared with the marketed and wet granulation formulation. In addition, the short term stability testing of the optimized batch was performed. The optimized inclusioncomplex of hydroxypropyl beta-cyclodextrin (HP-ß-CD) was selected based on a phase solubility study in 1:1 ratio with drug toimprove solubility. The optimized batch was prepared by MADG at granulator speed of 540rpm, using 4.30 % PVPK30, and 1.5 % Aeroperl 300. It showed a disintegration time of 208.33 sec.Percentage drug release was 95.02 % in 30 mins, and hardness 5.4 kg/cm2. The stability study results confirmed the stability of the tablets. The Bicalutamide tablet was successfully formulated using the MADG technique. The parameters affecting the in-vitro dissolution were identified and optimized, leading to better bioavailability. Keywords: Bicalutamide, Moisture Activated Dry Granulation technology (MADG), hydroxypropyl beta-cyclodextrin (HP-β-CD), Box Behnken design (BBD), Croscarmellose sodium","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41894935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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