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Simultaneous Analysis of Trace Tetracyclines Antibiotics in Wastewater with Ultra-high Performance Liquid Chromatography Coupled with Mass Spectrometry 超高效液相色谱-质谱联用分析废水中痕量四环素类抗生素
Pub Date : 2023-10-20 DOI: 10.9734/jpri/2023/v35i277441
Hua Wang
A comprehensive method was developed for determination of tetracycline, oxytetracycline, chlortetracycline, and doxycycline in wastewater. Based on ultra-high performance liquid chromatography coupled with mass spectrometry (UHPLC–MS), the developed method was specific, sensitive, precise, and accurate. Specificity was confirmed with both retention time and accurate m/z value of four antibiotics. Good linearity was achieved for all compounds in the range 5-100 ng/mL. Repeatability of method was proved. The intra-day and inter-day precision were satisfied. The limit of detection and limit of quantification was low enough at several ng/mL. Recoveries were between 95% and 104% at three concentration levels. The concrete sample collected in local swine farm was determined to containing 15 ng/mL oxytetracycline. The developed method provides a reliable and robust tool that can be used for routine analysis of tetracyclines antibiotics in aqueous samples.
建立了测定废水中四环素、土霉素、金四素和强力霉素的综合方法。该方法以超高效液相色谱-质谱联用(UHPLC-MS)技术为基础,具有专属性强、灵敏度高、精密度高、准确度高等特点。4种抗生素的保留时间和准确的m/z值证实了特异性。所有化合物在5-100 ng/mL范围内均具有良好的线性关系。验证了方法的重复性。日内和日间精度均满足要求。检测限和定量限较低,仅为几ng/mL。在3种浓度水平下,加样回收率在95% ~ 104%之间。在当地养猪场采集的混凝土样品中,土霉素含量为15 ng/mL。该方法可用于水样中四环素类抗生素的常规分析。
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引用次数: 0
The Chinese-Han Population Carrying Wild-type Genotypes of SLCO1B1 388A>G, SLCO1B1 521T>C, CYP3A4 1B, CYP3A4 1G, and CYP3A5*3 Exhibits a Significant Alteration in the Pharmacokinetics of Atorvastatin Calcium 携带SLCO1B1 388A>G、SLCO1B1 521T>C、CYP3A4 1B、CYP3A4 1G和CYP3A5*3野生型基因型的中国汉族人群对阿托伐他汀钙的药代动力学有显著改变
Pub Date : 2023-10-19 DOI: 10.9734/jpri/2023/v35i277440
Binbin Xia, Xianjun Liu, Yali Li, Yang Liu, Wenfang Sun, Jing Chen, Liushui Li, Jingyao Pang, Shicai Chen, Hua Cheng
Due to the diverse genetic characteristics of metabolism and high drug plasma exposure, great inter-subject variability exists in the clinical efficacy and incidence of adverse events. This study aimed to evaluate the associations between the SLCO1B1 388A>G (rs2306283) polymorphism and the pharmacokinetics of atorvastatin calcium (AC) in healthy volunteers who carried the wild genotypes of SLCO1B1 521T>C (rs4149056), CYP3A4 1B (rs2740574), CYP3A4 1G (rs2242480), and CYP3A5*3 (rs776746). A FISH technique was employed to investigate the genetic polymorphisms in 187 healthy male volunteers. The pharmacokinetic study was conducted on a group of healthy male Chinese-Han volunteers with wild-type genotypes of SLCO1B1 521T>C, CYP3A4 1B, CYP3A41G and CYP3A53 genes, consisting of either mutant heterozygotes (n=10) or mutant homozygotes (n=10) of SLCO1B1 388A>G. The results were then compared to the pharmacokinetic parameters of AC in subjects with the wild-type genotype of SLCO1B1 388A>G, as previously described. Based on the distribution of genotypes, the 187 volunteers could be divided into 28 groups. The top 10 groups accounted for nearly 85% of the total volunteers. No significant differences (P>0.05) were observed in the pharmacokinetic parameters between subjects carrying homozygous and heterozygous genotypes of SLCO1B1 388A>G. However, The Cmax of subjects carrying the wild-type genotype of SLCO1B1 388A>G was about 14.75 times higher than that of the heterozygous genotype group and 10.43 times higher than that of the homozygous genotype group. The AUC0-72h of volunteers with the wild-type genotype of SLCO1B1 388A>G was about 13.81 times higher than that of the heterozygous genotype group and 11.96 times higher than that of the homozygous genotype group. Volunteers carrying wild genotypes of SLCO1B1 388A>G, SLCO1B1 521T>C, CYP3A4 1B, CYP3A4 1G, and CYP3A5*3 showed significantly higher levels of Cmax and AUC (P<0.01), as well as markedly decreased values of CLz/F and Vz/F (P<0.01) of AC. In conclusion, patients carrying the wild genotype of SLCO1B1 388A>G, SLCO1B1 521T>C, CYP3A41G, CYP3A41B, and CYP3A5*3 should receive a lower dose of AC to minimize the risk of adverse effects.
由于代谢遗传特征的多样性和药物血浆暴露量的高,临床疗效和不良事件发生率存在很大的学科间差异。本研究旨在评价携带SLCO1B1 521T>C (rs4149056)、CYP3A4 1B (rs2740574)、CYP3A4 1G (rs2242480)和CYP3A5*3 (rs776746)野生基因型的健康志愿者中SLCO1B1 388A>G (rs2306283)多态性与阿托伐他汀钙(AC)药代动力学的关系。采用FISH技术研究了187名健康男性志愿者的遗传多态性。在一组携带SLCO1B1 521T>C、CYP3A4 1B、CYP3A41G和CYP3A53基因野生型的健康汉族男性志愿者中进行了药代动力学研究,其中包括SLCO1B1 388A>G突变型杂合子(n=10)和突变型纯合子(n=10)。然后将结果与SLCO1B1 388A>G野生型基因型受试者的AC药代动力学参数进行比较,如前所述。根据基因型分布,187名志愿者可分为28组。排名前十的小组占志愿者总数的近85%。携带SLCO1B1 388A>G基因纯合型和杂合型受试者的药代动力学参数无显著差异(P>0.05)。而携带SLCO1B1 388A>G野生型基因型的受试者Cmax比杂合基因型组高14.75倍,比纯合基因型组高10.43倍。SLCO1B1 388A>G野生型基因型志愿者的AUC0-72h比杂合子基因型组高13.81倍,比纯合子基因型组高11.96倍。携带SLCO1B1 388A>G、SLCO1B1 521T>C、CYP3A41B、CYP3A41G和CYP3A5*3野生基因型的志愿者,AC的Cmax和AUC水平显著升高(P<0.01), CLz/F和Vz/F值显著降低(P<0.01)。综上所述,携带SLCO1B1 388A>G、SLCO1B1 521T>C、CYP3A41G、CYP3A41B和CYP3A5*3野生基因型的患者应减少AC剂量,以降低不良反应的风险。
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引用次数: 0
A Cross-sectional Study to Assess Pandu Vyadhi (Anemia) with Special Reference to RBC Indices and Morphology: A Study Protocol 一项评估Pandu Vyadhi(贫血)的横断面研究,特别参考红细胞指数和形态学:研究方案
Pub Date : 2023-10-16 DOI: 10.9734/jpri/2023/v35i267439
Seema H. Thakare, Umesh Patil
Background: Ayurveda is a science of life & its holistic approach towards Dietary habits, seasonal regimes, daily regimes, lifestyle practices helps to maintain health of an individual. Inadequate dietary intake or lack of balanced diet leads to malnutrition & has major role in manifestation of various diseases Pandu vyadhi is one among them. Considering the sign & symptoms the disease is correlated with Anemia. It is a major global public health problem & most prevalent nutritional deficiency disorder affecting one third of the world’s population. The disease is more prevalent in low-income countries. It affects the patient both physically & mentally. Among the different form of therapies used for treatment of anemia in modern medicine shows adverse effects ranging from mild to severe. So there is need to seek out the safe & effective Ayurvedic treatment for anaemia. Clinical symptoms & laboratory investigations both are necessary for accurate diagnosis of disease. But due to lack of proper investigative methods a case of anemia becomes difficult to diagnose for its different types as per Ayurveda. Aim: To study & assess Pandu vyadhi with Special Reference to RBC indices and Morphology on peripheral smear. Methods: This is descriptive cross sectional study which focuses on assessing Pandu vyadhi with Special Reference to RBC indices and Morphology on peripheral smear. Conclusion: The present study generates reliable data of Pandu vyadhi in relation to various laboratory parameters which helps to plan specific treatment as mentioned in Ayurvedic classics for different types of Pandu vyadhi. The use of large sample size will also improve the precision of the study and increase the generalizability of the result.
背景:阿育吠陀是一门生命科学;它对饮食习惯、季节制度、日常制度、生活方式的整体方法有助于保持个人健康。膳食摄入不足或饮食不均衡会导致营养不良。在各种疾病的表现中起着重要作用,Pandu vyadhi就是其中之一。考虑到符号&这种疾病的症状与贫血有关。这是一个重大的全球公共卫生问题。最普遍的营养缺乏症影响着世界三分之一的人口。这种疾病在低收入国家更为普遍。它既影响病人的身体,也影响病人的身体。精神上。在治疗贫血的不同形式的疗法中,现代医学显示出从轻微到严重的不良反应。所以有必要寻找安全的& &;治疗贫血的有效阿育吠陀疗法。临床症状&实验室调查对于准确诊断疾病都是必要的。但由于缺乏适当的调查方法,根据阿育吠陀的不同类型,贫血病例很难诊断。 目的:研究& &;特别参考外周血涂片红细胞指标和形态学评价Pandu vyadhi。 方法:采用描述性横断面研究方法,特别参考外周血涂片红细胞指数和形态学,对Pandu vyadhi进行评估。 结论:本研究获得了有关Pandu vyadhi的各种实验室参数的可靠数据,有助于制定阿育吠陀经典中对不同类型Pandu vyadhi的具体治疗方案。大样本量的使用也将提高研究的精度,增加结果的可推广性。
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引用次数: 0
Pushkarmoola (Inula racemosa Hook. F.): A Healing Legacy Unveiled - Exploring its Potent Anti-Pyretic and Medicinal Significance Pushkarmoola(总状菊)(f):揭开愈合的遗产-探索其有效的退热和药用意义
Pub Date : 2023-10-07 DOI: 10.9734/jpri/2023/v35i267438
None Anju K. l., Vaibhav Jaisawal, Sanjeev Kumar, Kiran Vashishtha, Anurag Mishra
Pushkarmoola, scientifically known as Inula racemosa Hook. F., is a robust herb belonging to the Asteraceae family. It is renowned for its potent medicinal properties, particularly in the realm of cardio-pulmonary health. In contemporary times, it enjoys significant recognition and popularity in both folk and traditional medicinal practices. Its versatility in addressing various health conditions such as fever (Jwara), cardiac diseases (Hridroga), wasting (Kshaya), cough (Kasa), respiratory diseases (Svasa), and tuberculosis (Rajayakshma) has been firmly established over the years through a combination of traditional wisdom and scientific investigation. Objective: This article provides a concise overview of the historical significance of Inula in medicine. Inula is a valuable source of natural compounds, and this article covers their pharmacological, biochemical, and clinical studies conducted in both in-vitro and in-vivo settings. Furthermore, it places particular emphasis on Inula's widespread use in Ayurvedic literature particularly as a remedy for fever (Jwara). Data Source: The available literature on Pushkaramoola from original Ayurvedic scriptures, classical Ayurvedic texts from different periods, Indian Ayurvedic Pharmacopoeia, and scientific databases such as ScienceDirect, PubMed, and Google Scholar. Review Methods: Numerous references to Pushkaramoola, found in Ayurvedic classics, journals, and traditional knowledge sources, were thoroughly compiled, and analyzed. The extensive data revealed its potential as a potent antipyretic, as it is prominently featured in formulations designed to alleviate fever. Additionally, both in vivo and in vitro studies have provided evidence of its antibacterial, anti-inflammatory, antioxidant and antifungal properties. Conclusion: This article encourages future researchers to delve deeper into the anti-pyretic properties of Pushkarmoola, as it has been extensively documented in ancient texts for its effectiveness in treating various types of fever (jwara). This historical evidence serves as a compelling reason for scholars to explore and expand upon the potential anti-fever benefits of Pushkarmoola.
Pushkarmoola,科学上被称为Inula racemosa Hook。是一种强壮的草本植物,属于菊科。它以其强大的药用特性而闻名,特别是在心肺健康领域。在当代,它在民间和传统医学实践中都得到了极大的认可和普及。多年来,通过传统智慧和科学研究的结合,它在解决各种健康状况方面的多功能性,如发烧(Jwara)、心脏病(Hridroga)、消瘦(Kshaya)、咳嗽(Kasa)、呼吸系统疾病(Svasa)和结核病(Rajayakshma)。目的:本文简要介绍了菊属植物在医学上的历史意义。菊属植物是一种有价值的天然化合物来源,本文涵盖了它们在体外和体内环境下进行的药理学、生化和临床研究。此外,它特别强调了Inula在阿育吠陀文献中的广泛使用,特别是作为发烧的药物(Jwara)。数据来源:关于普什卡拉穆拉的现有文献,包括原始阿育吠陀经典,不同时期的经典阿育吠陀文本,印度阿育吠陀药典,以及科学数据库,如ScienceDirect, PubMed和Google Scholar。 复习方法:对阿育吠陀经典、期刊和传统知识来源中发现的大量关于Pushkaramoola的参考文献进行了彻底的汇编和分析。广泛的数据显示其作为一种有效的退烧药的潜力,因为它在旨在缓解发烧的配方中具有突出的特点。此外,体内和体外研究都提供了其抗菌、抗炎、抗氧化和抗真菌特性的证据。 结论:这篇文章鼓励未来的研究人员深入研究Pushkarmoola的解热特性,因为它在古代文献中被广泛记录为治疗各种类型的发烧(jwara)。这一历史证据为学者们探索和扩展Pushkarmoola潜在的退烧益处提供了一个令人信服的理由。
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引用次数: 0
Medical Students' Perception of Colors Influence on the Learning Process 医学生色彩知觉对学习过程的影响
Pub Date : 2023-10-06 DOI: 10.9734/jpri/2023/v35i267437
Syed Sajid Hussain Shah, Asmara Syed, Amin Khalid Makhdoom, Dhari Atallah Alshammari, Saima Syed
Background: Human being are affected by the surrounding environment. One of the component of the environment is presence of various colors. Different colors exert different impact on human psychology and the state of human psychology affects the learning process. Aims: We aimed to evaluate the perception of medical students about the different colors employed for the text and background that ease the process of readability and learning. Study Design: Cross-sectional study. Place and Duration of Study: Faculty of Medicine at Northern Border University (NBU) between 1/1/2023 and 1/2/2023. Methodology: After the ethical approval, the questionnaire was circulated among the willing participants from the students of the Faculty of Medicine – NBU. There are two components of the questionnaire. The 1st part comprised a color chart in which there were one hundred different combinations of text and background colors. The 2nd part contains basic information such as the study year of MBBS and gender along with the questions regarding the color text that is easier to read & understand and the background color that they like most. Results: One hundred and seventeen (117) medical students participated in this study (72 females and 45 males).The majority of students liked the black text with a white background while a small number liked the other text and background colors such as black and cyan, yellow and black, white and green, and black and yellow, respectively. Conclusion: The perception of the majority of medical students is that the most easily read text is the text written with black color on a white background.
& # x0D;背景:人类受到周围环境的影响。环境的一个组成部分是各种颜色的存在。不同的颜色对人的心理产生不同的影响,人的心理状态影响学习过程。& # x0D;目的:我们旨在评估医学生对不同颜色的文字和背景的感知,以方便阅读和学习的过程。 研究设计:横断面研究。 学习地点和时间:2023年1月1日至2023年1月2日在北方边境大学医学院学习。 方法:经伦理审定后,在有意愿的北洋医科大学医学院学生中分发问卷。问卷有两个组成部分。第一部分包括一个颜色表,其中有一百种不同的文本和背景颜色组合。第二部分包含基本信息,如MBBS的学习年份和性别,以及关于颜色文本的问题,更容易阅读& &;以及他们最喜欢的背景色。 结果:117名医学生参与本研究,其中女72名,男45名。大多数学生喜欢白色背景的黑色文本,而少数学生喜欢其他文本和背景颜色,如黑色和青色,黄色和黑色,白色和绿色,黑色和黄色。 结论:大多数医学生认为最容易阅读的文字是白底黑字。
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引用次数: 0
Dimension of Psycho-social Distress and Associated-complications in Type 2 Diabetes Population 2型糖尿病人群社会心理困扰的维度及相关并发症
Pub Date : 2023-10-05 DOI: 10.9734/jpri/2023/v35i267436
Amala Joseph, Aiswarya Thomas, Jilbi Josey, Rosmin Jacob
Aim: This study analyzes the psycho-social challenges and problems experienced by individuals diagnosed with type 2 diabetes, utilizing the diabetes distress scale (DDS). Moreover, this research offers patients recommendations and guidance to enhance their overall well-being and health-related quality of life. Methodology: Six months of prospective observational study in five departments of a tertiary care hospital was conducted. During the investigation period, 205 patients' diabetes conditions were analyzed and assessed through direct patient interviews, and the results were analyzed using a chi-square test. Results: According to statistical analysis, it has been determined that neuropathy (χ2 =7.225, p=0.027), Coronary Artery Disease (CAD) (χ2=6.375, p=0.041), diabetes foot (χ2 =8.416, p=0.015), and retinopathy (χ2=6.189, p=0.045) are the primary emotional-related issues. Additionally, in regimen-related risk, diabetes foot complications (χ2 =16.354, p<0.001) exhibit a high significance level, along with others. Conclusions: The study facilitated the assessment and examination of diabetes patients' emotional, dietary, medical, and social suffering. Diabetes neuropathy, retinopathy, foot ulcer, CAD, and poor healing were the higher perplexities discovered by the investigation.
目的:本研究利用糖尿病困扰量表(DDS)分析2型糖尿病患者所面临的社会心理挑战和问题。此外,本研究为患者提供建议和指导,以提高他们的整体福祉和健康相关的生活质量。 方法:对某三级医院5个科室进行为期6个月的前瞻性观察研究。在调查期间,通过对患者的直接访谈,对205例患者的糖尿病病情进行了分析和评估,并对结果进行了卡方检验。结果:通过统计分析,确定神经病变(χ2= 7.225, p=0.027)、冠心病(χ2=6.375, p=0.041)、糖尿病足(χ2= 8.416, p=0.015)、视网膜病变(χ2=6.189, p=0.045)是主要的情绪相关问题。此外,在方案相关风险中,糖尿病足并发症(χ2 =16.354, p<0.001)与其他因素一起显示出高度显著性水平。 结论:本研究促进了糖尿病患者情绪、饮食、医疗和社会痛苦的评估和检查。糖尿病神经病变、视网膜病变、足部溃疡、CAD和愈合不良是调查发现的较高困惑。
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引用次数: 0
Children’s Attitude and Preferences of Paediatric Dentist’s Attire and Dental Clinic Set up in Paediatric Dental Practice 儿童对儿科牙科医师服装及牙科诊所设置的态度及偏好
Pub Date : 2023-09-28 DOI: 10.9734/jpri/2023/v35i267433
Rucha Bhise Patil, Sanjana Kodical, Amil Joshi, Apurva Nampalle, Miloni Sanghavi
Background: The biggest issue for any paediatric dentist, despite the many advancements in the field of paediatric dentistry, is to reduce patient anxiety associated with dental visits and encourage them to accept the necessary care. In order to establish a good relationship with the child, the dentist's presentation is crucial. Aim: To assess the children’s perception and preference towards the dentist’s appearance, dental clinic set-up. Materials and Methods: A questionnaire designed to evaluate children’s attitudes and preferences towards dentists was distributed in public schools and was completed by 1012 children (459 males, 553 females) aged between 7–13 years. Data collected was entered into a computer and analyzed using SPSS software. Descriptive and inferential analysis was carried out. Results: For about 526 children (52%) it was their first visit while 486 children (48%) had been to the dentist before. Children’s preferred attire for receptionists was casual clothes (50.2%) while for the dentist, most of them (42.7%) preferred scrubs. Most (69.1%) of the children were not scared with the use of PPE kit. Conclusion: The findings of this study can assist dentists in determining what to wear when working with kids to lessen their anxiety and enhance healthcare delivery.
背景:尽管儿科牙科领域取得了许多进步,但对于任何儿科牙医来说,最大的问题是减少患者与牙科就诊相关的焦虑,并鼓励他们接受必要的护理。为了与孩子建立良好的关系,牙医的介绍是至关重要的。 目的:探讨儿童对牙科医生外表、牙科诊所设置的认知和偏好。 材料与方法:在公立学校发放儿童对牙医的态度和偏好问卷,共1012名7-13岁儿童(男459名,女553名)完成问卷调查。将收集到的数据输入计算机,并使用SPSS软件进行分析。进行了描述性和推理分析。 结果:526例(52%)患儿为首次就诊,486例(48%)患儿为首次就诊。儿童最喜欢接待员的服装是休闲装(50.2%),而最喜欢牙医的服装是磨砂服(42.7%)。大多数(69.1%)儿童在使用个人防护装备时不感到害怕。 结论:本研究的发现可以帮助牙医决定在与孩子一起工作时穿什么,以减轻他们的焦虑,提高医疗保健服务。
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引用次数: 0
Standardization of Gowthamar chooranam – A Polyherbal Siddha Formulations in the Management of Swasakasam (Bronchial Asthma) gothamar chooranam的标准化-一种治疗支气管哮喘的多草药悉达配方
Pub Date : 2023-09-25 DOI: 10.9734/jpri/2023/v35i257432
None Anitha Kalaivani M., None Shamshalniha S., None Anbu N.
Background: Siddha medicine is a unique one as it is not only a curative but also preventive and to achieve the healthy body and mind. Siddha medicines revitalize and rejuvenate the body. Bronchial asthma, characterized by chronic airway obstruction and increased airway hyper responsiveness leads to symptoms of wheeze, cough, chest tightness and difficulty in breathing. It affecting any age, race and socio-economic class globally and its prevalence is changing upwards worldwide. The increase in prevalence may be due to changes in lifestyle, rapid industrialization, tobacco, smoke, viral infections, chemical irritants and increase in air pollution. Siddha, an ancient system of Indian Medicine has recommended a number of drugs for indigenous plant sources for the treatment of Bronchial Asthma. One among them is Siddha polyherbal formulation Gowthamar chooranam. Aim: The aim of the present study was to identify the presence of bioactive phytocomponents in the Siddha polyherbal drug formulation Gowthamar chooranam by subjecting the drug to various studies like physicochemical analysis, phytochemical screening, and HPTLC. Methods: The ingredients present in the Siddha polyherbal formulation Gowthamar chooranam was first authenticated by the botanist and was purified. The purified ingredients of the drug was grounded to make a powdered form. The prepared siddha polyherbal formulation Gowthamar chooranam was sent it to the lab for the physiochemical analysis, phytochemical screening and HPTLC. The mentioned physicochemical and phytochemical analysis was conducted at The Tamil Nadu Dr. MGR Medical University, located at No.69, Anna Salai, Guindy, Chennai – 600 032. The HPTLC was carried out at Noble Research Solutions in Kolathur, Chennai – 600 099. Results: Physicochemical analysis of the study revealed 0.64% of loss on drying (LOD) at 1050C, 2.41% of total ash value, 0.8394% of acid insoluble ash, 1.65% of water soluble ash, 62.30% of water soluble extraction, 11.25% of Alcohol soluble extractive. Phytochemical screening showed the presence of bioactive compounds such as carbohydrates, saponin, phenols, tannin, flavonoids, diterpenes and Gum and mucilage. Seven distinct peaks are seen in the sample’s HPTLC finger printing examination, which indicates that it contains seven different phytocomponents. The highest Rf value of the peaks varies from 0.05 to 0.75. Conclusion: The findings aid in determining the formulations of siddha polyherbal drug Gowthamar chooranam and it reveals the presence of physicochemical and phytochemical properties of the drug which ensures the safety and therapeutic potential in the management of Swasakaasam (Bronchial Asthma) The study drug can also be used as a reference norms for the medicine of standard pharmaceutical product and further quality control enquires. This study provides the evidence for future clinical studies.
背景:悉达医学是一种独特的医学,因为它不仅是一种治疗,而且是预防和实现身心健康。悉达药物使身体恢复活力和活力。支气管哮喘以慢性气道阻塞和气道高反应性增加为特征,可导致喘息、咳嗽、胸闷和呼吸困难等症状。它影响全球任何年龄、种族和社会经济阶层,其患病率在全球范围内呈上升趋势。患病率的增加可能是由于生活方式的改变、快速工业化、烟草、烟雾、病毒感染、化学刺激物和空气污染的增加。Siddha,一个古老的印度医学系统,推荐了一些治疗支气管哮喘的本土植物药物。其中之一是悉达多草药配方Gowthamar chooranam。目的:本研究的目的是通过理化分析、植物化学筛选和HPTLC等多种研究,确定悉达多药制剂Gowthamar chooranam中生物活性植物成分的存在。方法:Siddha复方制剂Gowthamar chooranam中的成分首先由植物学家鉴定并纯化。这种药物的纯化成分被磨成粉末。将制备的siddha复方Gowthamar chooranam送到实验室进行理化分析、植物化学筛选和HPTLC。上述物理化学和植物化学分析是在泰米尔纳德邦MGR博士医科大学进行的,该大学位于金奈Guindy Anna Salai 69号,邮编:600032。HPTLC在Noble Research Solutions, Kolathur, Chennai - 600 099进行。 结果:1050℃干燥损失率为0.64%,总灰分为2.41%,酸不溶灰分为0.8394%,水溶性灰分为1.65%,水溶性萃取物为62.30%,醇溶萃取物为11.25%。植物化学筛选显示其含有碳水化合物、皂苷、酚类、单宁、黄酮类、二萜、树胶和粘液等生物活性化合物。在样品的HPTLC指纹图谱检查中可以看到七个不同的峰,这表明它含有七种不同的植物成分。峰的最高Rf值在0.05 ~ 0.75之间变化。 结论:本研究结果为中药复方制剂的确定提供了依据,揭示了药物的理化和植物化学性质,保证了药物在支气管哮喘治疗中的安全性和治疗潜力,也可作为标准药品的用药参考规范和进一步的质量控制咨询。本研究为今后的临床研究提供了依据。
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引用次数: 0
The Therapeutic Effects of Lactobacillus reuteri Supplementation in Various Conditions: A Systematic Review 补充罗伊氏乳杆菌在不同条件下的治疗效果:系统综述
Pub Date : 2023-09-23 DOI: 10.9734/jpri/2023/v35i257431
None Dhivya K., None Backkiyashree D., None Pratibha N., None Nandhani N., None Vincy Santhana Sophia B., None Bala Abirami M.
Background: Lactobacillus reuteri (L. reuteri) is a probiotic which confers health benefits on the host when administered. The safety and efficacy of L. reuteri in human health and diseases were assessed through this study. Objectives: To determine the efficacy of L. reuteri supplement in various diseases. Methods: PRISMA guideline was used and systematically searched the Cochrane Library and PubMed electronic databases for studies reporting effects of L. reuteri supplementation consumption in improving patient’s health in different condition/diseases. Twenty-two eligible studies were selected and 1889 patients from general population have been included in our study. Results and Discussion: From included studies, the predictive performance of L. reuteri produces significant improvement in treatment of various conditions and diseases. It acts by improving the gut microbiota of several conditions and inflammatory diseases can be managed in a better manner. Supplementation with L. reuteri decreased the severity of various diseases and side effects such as antibiotic associated diarrhea. Conclusion: The effect of L. reuteri varies depends on disease condition that was shown in our results. Hence, we conclude that administration of L. reuteri is considered safe and effective when taken as supplementation.
背景:罗伊氏乳杆菌(L. reuteri)是一种益生菌,当给药时对宿主健康有益。本研究评价了罗伊氏乳杆菌对人体健康和疾病的安全性和有效性。 目的:观察罗伊氏乳杆菌补充剂对多种疾病的治疗效果。方法:采用PRISMA指南,系统检索Cochrane图书馆和PubMed电子数据库,查找报告补充罗伊氏乳杆菌对改善不同病情/疾病患者健康效果的研究。我们从普通人群中选择了22项符合条件的研究,并纳入了1889例患者。 结果和讨论:从纳入的研究中,罗伊氏乳杆菌的预测性能在治疗各种病症和疾病方面产生了显着改善。它的作用是改善几种情况下的肠道微生物群,炎症性疾病可以以更好的方式得到控制。补充罗伊氏乳杆菌降低了各种疾病的严重程度和副作用,如抗生素相关性腹泻。结论:罗伊氏乳杆菌的作用取决于我们的结果所显示的疾病状况。因此,我们得出结论,罗伊氏乳杆菌的管理被认为是安全有效的补充。
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引用次数: 0
Incidence of Dental Caries in Permanent Mandibular First Molar among North Indian Population 北印度人口恒下颌第一磨牙龋齿发生率调查
Pub Date : 2023-09-21 DOI: 10.9734/jpri/2023/v35i257430
Aashish Handa, Komaldeep Kaur Sandhu, Kanwalpreet Kaur Bhullar, Smiley Goyal
Dental caries is a multifactorial condition that is influenced by a number of factors, including nutrition, bacteria, saliva, tooth shape, environment, sex, geography, dietary patterns, and genetics. Only a small number of research in India have examined the prevalence of dental caries, particularly in adults. Aim: The purpose of the current study was to ascertain the incidence of dental caries in left and right mandibular first molars in adults attending the Out Patient Department. Materials and Methods: The present cross-sectional research was done among the 1287 patients. Clinical oral examinations consisted of visual examination and no radiograph was taken for the study. Chi-square test was used to statistically analyse the results. p value of <0.005 was employed throughout the study. Results: The current study found that the youngest age group (16 to 30 years old) had the significant caries levels, followed by middle-aged and older age groups. In comparison to the right mandibular molar, the left first molar showed a higher prevalence of caries, with males showing a higher rate than females. It also demonstrated that the dental caries prevalence remains high among rural population in comparison to urban population. Conclusion: Permanent first molar in early age group presented higher caries incidence.This finding can help in formulation of various preventive strategies.
龋齿是一种多因素的疾病,受多种因素的影响,包括营养、细菌、唾液、牙齿形状、环境、性别、地理、饮食模式和遗传。在印度,只有少数研究调查了龋齿的患病率,特别是在成年人中。目的:本研究的目的是了解在门诊就诊的成人左、右下颌第一磨牙龋齿的发生率。材料与方法:对1287例患者进行横断面研究。临床口腔检查包括目视检查,研究中未拍摄x线片。采用卡方检验对结果进行统计学分析。p值为<0.005。 结果:目前的研究发现,最年轻的年龄组(16 - 30岁)龋齿水平显著,其次是中老年人群。与右下颌磨牙相比,左第一磨牙的龋发病率更高,男性高于女性。研究还表明,与城市人口相比,农村人口的龋齿患病率仍然很高。结论:早期恒牙第一磨牙患龋率较高。这一发现有助于制定各种预防战略。
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引用次数: 0
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Journal of Pharmaceutical Research International
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