Pub Date : 2021-12-30DOI: 10.7897/2277-4572.106220
Y. H., Anand Katti
Vrana chikitsa has been given more emphasis since Samhita period, an elaborated description found in Sushruta Samhita for its effective management under the heading of Shashti upakrama, out of which certain procedures are explained for the management of skin abnormalities which are called as Vaikrutapaha chikitsa, these procedures infer regarding the fact that cosmetology was given utmost importance in Ayurveda.In current scenario, the practice of Vaikrutapaha chikitsa remains unnoticed in the presence of modern surgical measures, these are costly, may be out of reach for common man. So, there is need of natural result-oriented procedure which are economical and carries minimal side effects. So, these techniques can be critically evaluated and implemented for the curative and cosmetic aspect of Vrana chikitsa.
{"title":"A REVIEW ON VAIKRUTAPAHA CHIKITSA IN THE MANAGEMENT OF VRANA (WOUND)","authors":"Y. H., Anand Katti","doi":"10.7897/2277-4572.106220","DOIUrl":"https://doi.org/10.7897/2277-4572.106220","url":null,"abstract":"Vrana chikitsa has been given more emphasis since Samhita period, an elaborated description found in Sushruta Samhita for its effective management under the heading of Shashti upakrama, out of which certain procedures are explained for the management of skin abnormalities which are called as Vaikrutapaha chikitsa, these procedures infer regarding the fact that cosmetology was given utmost importance in Ayurveda.In current scenario, the practice of Vaikrutapaha chikitsa remains unnoticed in the presence of modern surgical measures, these are costly, may be out of reach for common man. So, there is need of natural result-oriented procedure which are economical and carries minimal side effects. So, these techniques can be critically evaluated and implemented for the curative and cosmetic aspect of Vrana chikitsa.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"34 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90454856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-30DOI: 10.7897/2277-4572.106222
Anand Rajaram Mirajakar, Anand Katti
Rasashastra is a unique branch of Ayurveda. Rasadravyas gain importance as they produce great results with little dose. Sudha varga are the class of rasa dravya which are predominantly calcium compounds. Sudha varga includes Churna, varatika, shukti, shankha and so on. Sudha is employed therapeutically in the form of churna, churnodaka, lavana, navasadara bhashpa drava. Sudha churna is basically calcium oxide. Sudhachurna is indicated in conditions of krimiroga, mukhapaka, amlapitta and vrushchika damsha. According to Rasatarangini, Churnodaka is used in dravana, swedana, bhavana, nimajjana, dhalana, pachana. The sudhalavana is useful in raktasrava and bhashpa drava in murcha.
{"title":"UTILITY OF SUDHA CHURNA IN AYURVEDA: A CRITICAL REVIEW","authors":"Anand Rajaram Mirajakar, Anand Katti","doi":"10.7897/2277-4572.106222","DOIUrl":"https://doi.org/10.7897/2277-4572.106222","url":null,"abstract":"Rasashastra is a unique branch of Ayurveda. Rasadravyas gain importance as they produce great results with little dose. Sudha varga are the class of rasa dravya which are predominantly calcium compounds. Sudha varga includes Churna, varatika, shukti, shankha and so on. Sudha is employed therapeutically in the form of churna, churnodaka, lavana, navasadara bhashpa drava. Sudha churna is basically calcium oxide. Sudhachurna is indicated in conditions of krimiroga, mukhapaka, amlapitta and vrushchika damsha. According to Rasatarangini, Churnodaka is used in dravana, swedana, bhavana, nimajjana, dhalana, pachana. The sudhalavana is useful in raktasrava and bhashpa drava in murcha.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74211876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-31DOI: 10.7897/2277-4572.105218
A. Pasha, C. Somashekhar
The aim of the present work was to develop sustained release Lornoxicam matrix tablets with polymers like HPMC K15M, Ethyl cellulose, and Crospovidone as carriers in varying quantities. Direct compression was used to make matrix tablets. Various assessment parameters, such as hardness, friability, thickness, percent drug content, weight variation, and so on, were applied to the prepared formulations. In vitro dissolution studies were carried out for 24 hrs. The tablets were subjected to in-vitro drug release in (pH 1.2) for first 2 hrs. Then followed by (pH 6.8) phosphate buffer for next 22 hrs. And the results showed that among the six formulations FL3 showed good dissolution profile to control the drug release respectively. The drug and polymer compatibility were tested using FT-IR spectroscopy, which revealed that the drug was compatible with all polymers. It is also required to design an appropriate prolonged release formulation for Lornoxicam in order to maintain the drug's release. Hence by using the compatible polymers sustained release tablets were formulated and subjected for various types of evaluation parameters like friability, hardness, drug content and dissolution behaviour. Finally, the findings reveal that the prepared sustained release matrix tablets of lornoxicam have improved efficacy and patient compliance.
{"title":"FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF LORNOXICAM BY DIRECT COMPRESSION METHOD","authors":"A. Pasha, C. Somashekhar","doi":"10.7897/2277-4572.105218","DOIUrl":"https://doi.org/10.7897/2277-4572.105218","url":null,"abstract":"The aim of the present work was to develop sustained release Lornoxicam matrix tablets with polymers like HPMC K15M, Ethyl cellulose, and Crospovidone as carriers in varying quantities. Direct compression was used to make matrix tablets. Various assessment parameters, such as hardness, friability, thickness, percent drug content, weight variation, and so on, were applied to the prepared formulations. In vitro dissolution studies were carried out for 24 hrs. The tablets were subjected to in-vitro drug release in (pH 1.2) for first 2 hrs. Then followed by (pH 6.8) phosphate buffer for next 22 hrs. And the results showed that among the six formulations FL3 showed good dissolution profile to control the drug release respectively. The drug and polymer compatibility were tested using FT-IR spectroscopy, which revealed that the drug was compatible with all polymers. It is also required to design an appropriate prolonged release formulation for Lornoxicam in order to maintain the drug's release. Hence by using the compatible polymers sustained release tablets were formulated and subjected for various types of evaluation parameters like friability, hardness, drug content and dissolution behaviour. Finally, the findings reveal that the prepared sustained release matrix tablets of lornoxicam have improved efficacy and patient compliance.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84654117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-31DOI: 10.7897/2277-4572.105217
Sreekala Vijayan, J. Kishore
Background: Paracetamol toxicity is currently the single most important cause for acute liver failure and is associated with significant number of deaths. Nilitanduliyadi leha is one among the formulation explained in the context of Vishahara yogas (anti-poisonous formulations) in the text Vishavaidya Jyotsnika. Objectives: To experimentally evaluate the hepatoprotective activity of nilitanduliyadi leha in paracetamol induced hepatotoxicity in Wistar albino rats. Methods: Albino Wistar rats of either sex weighing 200 – 250, g were selected and divided into four groups of six animals in each group (n = 6). Treatment was given for 7 days. Blood was drawn and sent for tests and important organs like liver and kidney were dissected out, cleaned to remove extraneous tissues, blotted to remove blood stain and weighed. A piece of liver tissue was preserved in 10% formalin for histopathological processing. Results: The formulation has helped in balancing the biochemical parameters studied almost as efficiently as the standard drug. In the antioxidant study also, the drug has given good results and shows even slightly more effective than the standard drug. The histopathology study also reveals mild protection and regeneration of tissues by the effect of test drug. Conclusion: This present study proves that the formulation is having a comparable hepato protective activity with that of silymarin.
{"title":"AN EXPERIMENTAL STUDY TO EVALUATE THE HEPATOPROTECTIVE ACTIVITY OF NILITANDULIYADI LEHA IN PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR ALBINO RATS","authors":"Sreekala Vijayan, J. Kishore","doi":"10.7897/2277-4572.105217","DOIUrl":"https://doi.org/10.7897/2277-4572.105217","url":null,"abstract":"Background: Paracetamol toxicity is currently the single most important cause for acute liver failure and is associated with significant number of deaths. Nilitanduliyadi leha is one among the formulation explained in the context of Vishahara yogas (anti-poisonous formulations) in the text Vishavaidya Jyotsnika. Objectives: To experimentally evaluate the hepatoprotective activity of nilitanduliyadi leha in paracetamol induced hepatotoxicity in Wistar albino rats. Methods: Albino Wistar rats of either sex weighing 200 – 250, g were selected and divided into four groups of six animals in each group (n = 6). Treatment was given for 7 days. Blood was drawn and sent for tests and important organs like liver and kidney were dissected out, cleaned to remove extraneous tissues, blotted to remove blood stain and weighed. A piece of liver tissue was preserved in 10% formalin for histopathological processing. Results: The formulation has helped in balancing the biochemical parameters studied almost as efficiently as the standard drug. In the antioxidant study also, the drug has given good results and shows even slightly more effective than the standard drug. The histopathology study also reveals mild protection and regeneration of tissues by the effect of test drug. Conclusion: This present study proves that the formulation is having a comparable hepato protective activity with that of silymarin.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84192443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lavana kalpana is one of the most commonly used dosage forms because of its easy administration and dosing. Arka lavana is a herbo mineral preparation containing Upavisha Arka (Calotropis procera) and Saindhava lavana. It is used in the management of Yakrit pleeha, Udara and Gulma roga. As it contains Upavisha, standardization becomes necessary to keep up its therapeutic efficacy. In this study an attempt has been made to find out the authenticity of the raw drugs, to prepare and analyse Arka lavana to set the preliminary standards for the same. Arka lavana was prepared as per the reference of Bhaishajya ratnavali. The analytical study was carried out in terms of organoleptic, physicochemical and TLC evaluation and results were noted. The pharmaceutical and analytical results can be used as reference standard for quality assurance and standardization of Arka lavana for further study.
{"title":"ARKA LAVANA THE FORMULATION OF UPAVISHA ARKA (CALOTROPIS PROCERA AIT. R. BR.): AN ANALYTICAL PROFILE","authors":"Chandankhede Aditi Vasudeorao, Anjankar Meghsham Pramodrao, Nikam Ashwin Vithalrao, Pawade Uday Venkatrao","doi":"10.7897/2277-4572.104216","DOIUrl":"https://doi.org/10.7897/2277-4572.104216","url":null,"abstract":"Lavana kalpana is one of the most commonly used dosage forms because of its easy administration and dosing. Arka lavana is a herbo mineral preparation containing Upavisha Arka (Calotropis procera) and Saindhava lavana. It is used in the management of Yakrit pleeha, Udara and Gulma roga. As it contains Upavisha, standardization becomes necessary to keep up its therapeutic efficacy. In this study an attempt has been made to find out the authenticity of the raw drugs, to prepare and analyse Arka lavana to set the preliminary standards for the same. Arka lavana was prepared as per the reference of Bhaishajya ratnavali. The analytical study was carried out in terms of organoleptic, physicochemical and TLC evaluation and results were noted. The pharmaceutical and analytical results can be used as reference standard for quality assurance and standardization of Arka lavana for further study.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85531016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-23DOI: 10.7897/2277-4572.104213
D. Rakshitha, B. PallaviK, Gazala Hussain, Archana Pagad
Bhaishajya Ratnavali by Kaviraj Govinda Das Sen of 18th century is an authentic book of Ayurveda science includes systematic description of diseases along with treatment aspects. Under Kshudraroga Chikitsa Prakarana, detailed information regarding kesharanjana has been explained with description of kesharanjana yoga. This article mainly focuses on the kesharanjana yoga mentioned in this book for better nourishment and coloring of hair. Review on kesharanjana yoga mentioned in Bhaishajya Ratnavali was analyzed and summarized for better usage and understanding. Initially author explains few preparations to apply as lepa (application) over scalp or hairs and later nasya (inhalation therapy) procedure for hair care. Most of the drugs used are rasayana (immune modulator) in nature and has keshya (hair tonic) property which forms the prime factor in using these drugs. Direct application as lepa and also nasya procedure would help in better nourishment and also proper growth of hair. Owing to the properties of drugs used for the preparations which are useful in many conditions of hair problems. By following these yogas and with proper pathya one can get benefited from khalitya, palitya, and other conditions of hair.
18世纪Kaviraj Govinda Das Sen的Bhaishajya Ratnavali是一本正宗的阿育吠陀科学书籍，包括对疾病的系统描述以及治疗方面。在Kshudraroga Chikitsa Prakarana下，关于kesharanjana的详细信息已经通过kesharanjana瑜伽的描述进行了解释。这篇文章主要集中在这本书中提到的kesharanjana瑜伽，以更好地滋养和染色头发。为了更好的使用和理解，对《Bhaishajya Ratnavali》中提到的kesharanjana瑜伽进行了分析和总结。最初，作者解释了几种用于头皮或头发的lepa(涂抹)和后来用于头发护理的nasya(吸入疗法)程序的准备。大多数使用的药物本质上是rasayana(免疫调节剂)，并具有keshya(头发滋补品)属性，这是使用这些药物的主要因素。直接使用lepa和nasya程序将有助于更好的营养和头发的正常生长。由于用于制剂的药物的性质，在许多头发问题的条件下是有用的。通过遵循这些瑜伽和适当的pathya，一个人可以从头发的khalitya, palitya和其他状况中受益。
{"title":"KESHARANJANA YOGA IN BHAISHAJYA RATNAVALI: A REVIEW","authors":"D. Rakshitha, B. PallaviK, Gazala Hussain, Archana Pagad","doi":"10.7897/2277-4572.104213","DOIUrl":"https://doi.org/10.7897/2277-4572.104213","url":null,"abstract":"Bhaishajya Ratnavali by Kaviraj Govinda Das Sen of 18th century is an authentic book of Ayurveda science includes systematic description of diseases along with treatment aspects. Under Kshudraroga Chikitsa Prakarana, detailed information regarding kesharanjana has been explained with description of kesharanjana yoga. This article mainly focuses on the kesharanjana yoga mentioned in this book for better nourishment and coloring of hair. Review on kesharanjana yoga mentioned in Bhaishajya Ratnavali was analyzed and summarized for better usage and understanding. Initially author explains few preparations to apply as lepa (application) over scalp or hairs and later nasya (inhalation therapy) procedure for hair care. Most of the drugs used are rasayana (immune modulator) in nature and has keshya (hair tonic) property which forms the prime factor in using these drugs. Direct application as lepa and also nasya procedure would help in better nourishment and also proper growth of hair. Owing to the properties of drugs used for the preparations which are useful in many conditions of hair problems. By following these yogas and with proper pathya one can get benefited from khalitya, palitya, and other conditions of hair.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74002308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Snuhi (Euphorbia neriifolia Linn.) and its compound formulations are widely used in Ayurvedic classics to treat variety of disease conditions. Information pertaining to the formulations of Snuhi can be traced in various classical texts, under different chapters. In most of the formulations it is used as an ingredient. Snuhi Kshara is a single drug formulation of Upavisha Snuhi mentioned in Rasatarangini and Ayurvedsarasangraha. Kshara obtained from Snuhi is one of its dosage modifications, advocated in classics for therapeutic objectives. Very few attempts are made to formulate Snuhi Kshara. The present work has been carried out to provide the Standard Manufacturing Process and a systematic standardization profile for Snuhi Kshara. Snuhi Kshara was prepared according to procedure described in Sharangadhara Samhita followed by analytical standardisation. Standardization was done using guidelines of API, by employing tests like organoleptic (Colour, Odour, Taste), physicochemical (Loss on drying, Acid-insoluble ash, pH), Assay (Sodium, Potassium, Iron) and Thin Layer Chromatography. Findings of this work may enrich to documentary research as well as act as detailed scientific data about standardization of Snuhi Kshara for further studies.
{"title":"STANDARDIZATION OF SNUHI KSHARA THE FORMULATION OF UPAVISHA SNUHI (EUPHORBIA NERIIFOLIA LINN.): A PHARMACEUTICO-ANALYTICAL PROFILE","authors":"Asolkar Geeta Govindrao, Nikam Ashwin Vithalrao, Pawade Uday Venkatrao, Anjankar Meghsham Pramodrao","doi":"10.7897/2277-4572.104214","DOIUrl":"https://doi.org/10.7897/2277-4572.104214","url":null,"abstract":"Snuhi (Euphorbia neriifolia Linn.) and its compound formulations are widely used in Ayurvedic classics to treat variety of disease conditions. Information pertaining to the formulations of Snuhi can be traced in various classical texts, under different chapters. In most of the formulations it is used as an ingredient. Snuhi Kshara is a single drug formulation of Upavisha Snuhi mentioned in Rasatarangini and Ayurvedsarasangraha. Kshara obtained from Snuhi is one of its dosage modifications, advocated in classics for therapeutic objectives. Very few attempts are made to formulate Snuhi Kshara. The present work has been carried out to provide the Standard Manufacturing Process and a systematic standardization profile for Snuhi Kshara. Snuhi Kshara was prepared according to procedure described in Sharangadhara Samhita followed by analytical standardisation. Standardization was done using guidelines of API, by employing tests like organoleptic (Colour, Odour, Taste), physicochemical (Loss on drying, Acid-insoluble ash, pH), Assay (Sodium, Potassium, Iron) and Thin Layer Chromatography. Findings of this work may enrich to documentary research as well as act as detailed scientific data about standardization of Snuhi Kshara for further studies.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83120883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Analytical study of Ayurvedic formulation is the need of present scientific era. Though the Ayurvedic drugs are time tested and have been used successfully in the management of various ailments, it is now necessary to prove their quality, efficacy and safety to the scientific world through various parameters. Agadtantra is a branch of Ayurveda dealing with classification, mode of action, clinical manifestations and treatment of various poisons. Arka (Calotropis procera) is included in Upavisha by Rasatarangini. Arka Kshara is an alkaline preparation of Upavisha Arka (Calotropis procera) described in treating many disorders. Till date no data is available regarding analytical profile of Arka Kshara. So, the present study is planned to prepare Arka Kshara and develop its analytical profile. These findings will be useful in establishing quality control standards and standardization of Arka Kshara in future.
阿育吠陀配方的分析研究是当今科学时代的需要。虽然阿育吠陀药物经过了时间的考验，并已成功地用于治疗各种疾病，但现在有必要通过各种参数向科学界证明它们的质量、功效和安全性。阿加坦陀罗是阿育吠陀的一个分支，涉及分类、作用方式、临床表现和各种毒药的治疗。Arka (Calotropis procera)被Rasatarangini收录在Upavisha中。Arka Kshara是Upavisha Arka (Calotropis procera)的碱性制剂，用于治疗许多疾病。到目前为止，没有关于Arka Kshara分析剖面的数据。因此，本研究计划制备Arka Kshara并开发其分析概况。这些研究结果将有助于今后建立茶茶的质量控制标准和标准化。
{"title":"PHARMACEUTICO-ANALYTICAL PROFILE OF ARKA KSHARA THE FORMULATION OF UPAVISHA ARKA (CALOTROPIS PROCERA AIT. R. BR)","authors":"Chandekar Deepali Boudhadas, Pawade Uday Venkatrao, Nikam Ashwin Vithalrao, Anjankar Meghsham Pramodrao","doi":"10.7897/2277-4572.104215","DOIUrl":"https://doi.org/10.7897/2277-4572.104215","url":null,"abstract":"Analytical study of Ayurvedic formulation is the need of present scientific era. Though the Ayurvedic drugs are time tested and have been used successfully in the management of various ailments, it is now necessary to prove their quality, efficacy and safety to the scientific world through various parameters. Agadtantra is a branch of Ayurveda dealing with classification, mode of action, clinical manifestations and treatment of various poisons. Arka (Calotropis procera) is included in Upavisha by Rasatarangini. Arka Kshara is an alkaline preparation of Upavisha Arka (Calotropis procera) described in treating many disorders. Till date no data is available regarding analytical profile of Arka Kshara. So, the present study is planned to prepare Arka Kshara and develop its analytical profile. These findings will be useful in establishing quality control standards and standardization of Arka Kshara in future.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78680516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-23DOI: 10.7897/2277-4572.104211
T RanjithaM, C. Somashekhar
A new dosage form, Oral disintegrating tablets (ODT’s) as a replacement to conventional oral dosage forms. ODT’s are dosage forms they disintegrate in mouth offering various advantages such as better mouth feel, dose accuracy, improved stability and convenient dosing as compared to oral liquids. So, there is need to designed oral disintegrating tablet to release the medicaments with an enhanced rate. Mefenamic acid is an anti- inflammatory drug while Dicyclomine HCl is anti-cholinergic drug. The combination of Mefenamic acid & Dicyclomine HCl controls pain very effectively, also relaxes bodily spasm which commonly arises during menstruation or intestinal colic spasm. This combination gives the quick onset of action and fast relief than conventional dosage form. For preparation of oral disintegrating tablet nine formulations were designed using Croscarmellose sodium and Crospovidone as superdisintegrants in varying concentration. All the formulations were prepared by direct compression method. Thus, all the formulations of Mefenamic acid and Dicyclomine HCl oral disintegrating tablets were investigated, in which F9 formulation was optimized. The % drug release of, Oral disintegrating tablet batch F9 has shown 96.98% of Mefenamic acid and 94.02 % of Dicyclomine HCl in 18 min, disintegration time in 40 sec and wetting time in 25sec.
{"title":"PREPARATION AND EVALUATION OF MEFENAMIC ACID AND DICYCLOMINE HYDROCHLORIDE AS ORAL DISINTEGRATING TABLET BY DIRECT COMPRESSION METHOD","authors":"T RanjithaM, C. Somashekhar","doi":"10.7897/2277-4572.104211","DOIUrl":"https://doi.org/10.7897/2277-4572.104211","url":null,"abstract":"A new dosage form, Oral disintegrating tablets (ODT’s) as a replacement to conventional oral dosage forms. ODT’s are dosage forms they disintegrate in mouth offering various advantages such as better mouth feel, dose accuracy, improved stability and convenient dosing as compared to oral liquids. So, there is need to designed oral disintegrating tablet to release the medicaments with an enhanced rate. Mefenamic acid is an anti- inflammatory drug while Dicyclomine HCl is anti-cholinergic drug. The combination of Mefenamic acid & Dicyclomine HCl controls pain very effectively, also relaxes bodily spasm which commonly arises during menstruation or intestinal colic spasm. This combination gives the quick onset of action and fast relief than conventional dosage form. For preparation of oral disintegrating tablet nine formulations were designed using Croscarmellose sodium and Crospovidone as superdisintegrants in varying concentration. All the formulations were prepared by direct compression method. Thus, all the formulations of Mefenamic acid and Dicyclomine HCl oral disintegrating tablets were investigated, in which F9 formulation was optimized. The % drug release of, Oral disintegrating tablet batch F9 has shown 96.98% of Mefenamic acid and 94.02 % of Dicyclomine HCl in 18 min, disintegration time in 40 sec and wetting time in 25sec.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77724520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-23DOI: 10.7897/2277-4572.104212
Vitthal B. Bachate, Raman S. Belge
Migraine is a neurological disorder that is frequently characterized by intense and debilitating headaches. According to the records, Migraine tends to affect people aged 15 to 55 years and the extreme pain or headache can last for hours or even days. Migraine is the third most prevalant and 7thleading cause of disability worldwide. There is no direct reference of Migraine in Ayurveda, but signs and symptoms of migraine can be co-related with Shiroroga, one of which is Ardhavabhedak. In Ayurveda, Nasyakarma plays a very important role in the management of Urdhvajatrugat Vikara. Thus an attempt has been made to evaluate the probable efficacy of polyherbal formulation Ksheerbala Taila in Ardhavabhedak.
{"title":"EFFECT OF KSHEERBALA TAILA NASYA IN MIGRAINE WITH SPECIAL REFERENCE ARDHAVABHEDAK: A LITERARY REVIEW","authors":"Vitthal B. Bachate, Raman S. Belge","doi":"10.7897/2277-4572.104212","DOIUrl":"https://doi.org/10.7897/2277-4572.104212","url":null,"abstract":"Migraine is a neurological disorder that is frequently characterized by intense and debilitating headaches. According to the records, Migraine tends to affect people aged 15 to 55 years and the extreme pain or headache can last for hours or even days. Migraine is the third most prevalant and 7thleading cause of disability worldwide. There is no direct reference of Migraine in Ayurveda, but signs and symptoms of migraine can be co-related with Shiroroga, one of which is Ardhavabhedak. In Ayurveda, Nasyakarma plays a very important role in the management of Urdhvajatrugat Vikara. Thus an attempt has been made to evaluate the probable efficacy of polyherbal formulation Ksheerbala Taila in Ardhavabhedak.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"486 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75132283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：