Pub Date : 2021-05-31DOI: 10.7897/2277-4572.103208
E. Konack, J. B. Sokoudjou, N. Kodjio, G. T. Kamsu, H. B. L. Feudjio, J. Kana, D. Gatsing
Salmonella infections remain one of the major health problems in both poultry farming and human medicine. In addition, resistance to Salmonella has emerged as a global health problem in both sectors. The present study aimed at evaluating the in vivo antisalmonellal and antioxidant activities of 95° ethanol extract of Khaya grandifoliola using broiler chickens as animal model. Animals were divided into the normal control group, negative control group, positive control group and three test groups treated with the extract at 10, 20 and 40 mg/kg respectively. The antioxidant status of broiler chickens was also evaluated by measuring the concentration of enzymatic antioxidants (catalase, glutathione peroxidase) and biochemical markers (malondialdehyde and nitric oxide). The results showed that infected animals treated with the Khaya grandifoliola extract at 40 mg/kg recovered on day 11 after the beginning of the treatment and on day 13 for those treated at the 10 and 20 mg/kg. The antioxidant assay showed that the infection led to the reduction of enzymatic markers in the body of infected animals, while the treatment increases such makers. The infection resulted in a significant increase in serum and pulmonary malondialdehyde. It also caused a significant decrease in cardiac and pulmonary nitric oxide whereas the treatment depending on the doses of the extract tends to normalize these biochemical markers. The overall results showed that Khaya grandifoliola extract can be successfully used in the treatment of avian salmonellosis as well as the management of the oxidative stress caused by the infection.
{"title":"SALMONELLA TYPHIMURIUM INFECTION: ANTIOXIDANT STATUS OF INFECTED POULTRY AND EFFICACY OF TREATMENT WITH KHAYA GRANDIFOLIOLA EXTRACT","authors":"E. Konack, J. B. Sokoudjou, N. Kodjio, G. T. Kamsu, H. B. L. Feudjio, J. Kana, D. Gatsing","doi":"10.7897/2277-4572.103208","DOIUrl":"https://doi.org/10.7897/2277-4572.103208","url":null,"abstract":"Salmonella infections remain one of the major health problems in both poultry farming and human medicine. In addition, resistance to Salmonella has emerged as a global health problem in both sectors. The present study aimed at evaluating the in vivo antisalmonellal and antioxidant activities of 95° ethanol extract of Khaya grandifoliola using broiler chickens as animal model. Animals were divided into the normal control group, negative control group, positive control group and three test groups treated with the extract at 10, 20 and 40 mg/kg respectively. The antioxidant status of broiler chickens was also evaluated by measuring the concentration of enzymatic antioxidants (catalase, glutathione peroxidase) and biochemical markers (malondialdehyde and nitric oxide). The results showed that infected animals treated with the Khaya grandifoliola extract at 40 mg/kg recovered on day 11 after the beginning of the treatment and on day 13 for those treated at the 10 and 20 mg/kg. The antioxidant assay showed that the infection led to the reduction of enzymatic markers in the body of infected animals, while the treatment increases such makers. The infection resulted in a significant increase in serum and pulmonary malondialdehyde. It also caused a significant decrease in cardiac and pulmonary nitric oxide whereas the treatment depending on the doses of the extract tends to normalize these biochemical markers. The overall results showed that Khaya grandifoliola extract can be successfully used in the treatment of avian salmonellosis as well as the management of the oxidative stress caused by the infection.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"113 1","pages":"72-79"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74773881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.7897/2277-4572.103209
M PavankumarK, S. Parthiban
The goal of the current investigation is to formulate Fluconazole loaded microemulsion (ME) with Lemongrass oil for deeper skin penetration and to obtain the dual benefit of drug and oil combination to improve antifungal efficacy of a drug with a reduced dose. We developed a Pseudo ternary phase diagram to identify the microemulsion zone by using the oil (clove oil), surfactant (Tween 20 and Tween 80), and co-surfactant (Propylene glycol) by water titration method. We formulated six different formulations (LM1 – LM6) by changing the oil/surfactant and cosurfactant ratio. The developed microemulsion formulation was characterized for various parameters % Transmittance, viscosity, pH, drug content, surface morphology, zeta potential, and in-vitro drug release study. The optimized microemulsion emulsion formulation is further converted into Microemulgel by dispersing the ME into 2% w/v Carbapol gel (LM-G) and further evaluated for various parameters. The antifungal efficacy was carried out for ME and Microemulgel by diffusion method against Candida albicans (MTCC no: 227) and compared with marketed gel which showed LM and LM-G have a better antifungal effect than marketed product, proved that the synergistic effect could be achieved by both clove oil and fluconazole drug by microemulsion formulation with deeper skin penetration effect.
{"title":"DESIGN AND CHARACTERIZATION OF FLUCONAZOLE MICROEMULSION FORMULATED WITH LEMONGRASS OIL","authors":"M PavankumarK, S. Parthiban","doi":"10.7897/2277-4572.103209","DOIUrl":"https://doi.org/10.7897/2277-4572.103209","url":null,"abstract":"The goal of the current investigation is to formulate Fluconazole loaded microemulsion (ME) with Lemongrass oil for deeper skin penetration and to obtain the dual benefit of drug and oil combination to improve antifungal efficacy of a drug with a reduced dose. We developed a Pseudo ternary phase diagram to identify the microemulsion zone by using the oil (clove oil), surfactant (Tween 20 and Tween 80), and co-surfactant (Propylene glycol) by water titration method. We formulated six different formulations (LM1 – LM6) by changing the oil/surfactant and cosurfactant ratio. The developed microemulsion formulation was characterized for various parameters % Transmittance, viscosity, pH, drug content, surface morphology, zeta potential, and in-vitro drug release study. The optimized microemulsion emulsion formulation is further converted into Microemulgel by dispersing the ME into 2% w/v Carbapol gel (LM-G) and further evaluated for various parameters. The antifungal efficacy was carried out for ME and Microemulgel by diffusion method against Candida albicans (MTCC no: 227) and compared with marketed gel which showed LM and LM-G have a better antifungal effect than marketed product, proved that the synergistic effect could be achieved by both clove oil and fluconazole drug by microemulsion formulation with deeper skin penetration effect.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"39 1","pages":"80-86"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81639309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.7897/2277-4572.103210
M RaghuKumarH, S. Parthiban
The aim of the current study is to develop Levofloxacin loaded microemulsion formulated with mustard oil for better skin penetration effect and to obtain combined effect of both the oil and the drug to improve the efficacy with a reduced dose. Primarily we developed a pseudo ternary phase diagrams to find out the region of microemulsion formation zone by using oil (mustard oil), surfactant (Tween 20 and Tween 80), and co-surfactant (propylene glycol) by water titration method. We formulated six different formulations (MM1-MM6) by varying the concentrations of the oil water and surfactant and cosurfactant ratio. The developed microemulsion formulation was characterized for various parameters % Transmittance, viscosity, pH, drug content, surface morphology, zeta potential, and in-vitro drug release study. The selected microemulsion formulation is further converted in to microemulgel by dispersing the ME into 2%w/W Carbopol gel (MM-G) and various parameters are evaluated for the gel. The antimicrobial efficacy was carried out for ME and Microemulgel by well diffusion method against Staphylococcus aureus (MTCC: 737) compared with the standard streptomycin which showed that MM3 and MM-G have a better antimicrobial effect than standard proved that the drug levofloxacin and the mustard oil shows the synergistic effect in the Microemulsion formulation with better skin penetration effect.
{"title":"DEVELOPMENT OF LEVOFLOXACIN LOADED MICROEMULSION FORMULATED WITH MUSTARD OIL","authors":"M RaghuKumarH, S. Parthiban","doi":"10.7897/2277-4572.103210","DOIUrl":"https://doi.org/10.7897/2277-4572.103210","url":null,"abstract":"The aim of the current study is to develop Levofloxacin loaded microemulsion formulated with mustard oil for better skin penetration effect and to obtain combined effect of both the oil and the drug to improve the efficacy with a reduced dose. Primarily we developed a pseudo ternary phase diagrams to find out the region of microemulsion formation zone by using oil (mustard oil), surfactant (Tween 20 and Tween 80), and co-surfactant (propylene glycol) by water titration method. We formulated six different formulations (MM1-MM6) by varying the concentrations of the oil water and surfactant and cosurfactant ratio. The developed microemulsion formulation was characterized for various parameters % Transmittance, viscosity, pH, drug content, surface morphology, zeta potential, and in-vitro drug release study. The selected microemulsion formulation is further converted in to microemulgel by dispersing the ME into 2%w/W Carbopol gel (MM-G) and various parameters are evaluated for the gel. The antimicrobial efficacy was carried out for ME and Microemulgel by well diffusion method against Staphylococcus aureus (MTCC: 737) compared with the standard streptomycin which showed that MM3 and MM-G have a better antimicrobial effect than standard proved that the drug levofloxacin and the mustard oil shows the synergistic effect in the Microemulsion formulation with better skin penetration effect.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"5 1","pages":"87-93"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79123315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.7897/2277-4572.103207
Raman S. Belge, Rameshwar Pandey, P. Itankar
Background: Vanga Bhasma is said to possess antimicrobial activity (Jantughna Prabhava). Hence it was decided to evaluate the antimicrobial activity of Jarit Vanga Bhasma (JVB) prepared with special reference to Rasatarangini 18/29-33. Objectives: JVB was synthesized, analysed and its antimicrobial effects were studied in Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumonia, Escherichia coli and Candida albicans. Materials and Methods: The JVB was prepared and analyzed for the quality parameters mentioned in the Ayurvedic texts as well as the modern parameters like XRD, SEM and EDX to find out the nature of the Vanga Bhasma samples. The anti-microbial study was done to find out the anti-microbial efficacy of the JVB samples. Results and Conclusions: The adopted method for preparation of JVB was able to produce a Bhasma compatible to organoleptic parameters mentioned in the ancient texts. The obtained JVB was grayish white with the formation of the small sized particles as small as a nanoparticle which was confirmed by SEM study. XRD study confirms that Tin oxide is the major compound found in all the JVB samples. JVB showed antimicrobial activity in inhibiting the growth of Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumonia, Escherichia coli and Candida albicans with a concentration of 100mg/ml. The mean zone of inhibition was 12.33mm, 12.33mm, 14.66mm, 10.33mm and 16mm respectively. This outcome further supports the Krumighna and Jantughna properties (Anti-microbial activity) of Vanga Bhasma. Hence, JVB is said to possess Anti-Microbial activity.
{"title":"PHARMACEUTICO-ANALYTICAL AND ANTIMICROBIAL STUDY OF JARIT VANGA BHASMA PREPARED WITH SPECIAL REFERENCE TO RASATARANGINI","authors":"Raman S. Belge, Rameshwar Pandey, P. Itankar","doi":"10.7897/2277-4572.103207","DOIUrl":"https://doi.org/10.7897/2277-4572.103207","url":null,"abstract":"Background: Vanga Bhasma is said to possess antimicrobial activity (Jantughna Prabhava). Hence it was decided to evaluate the antimicrobial activity of Jarit Vanga Bhasma (JVB) prepared with special reference to Rasatarangini 18/29-33. Objectives: JVB was synthesized, analysed and its antimicrobial effects were studied in Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumonia, Escherichia coli and Candida albicans. Materials and Methods: The JVB was prepared and analyzed for the quality parameters mentioned in the Ayurvedic texts as well as the modern parameters like XRD, SEM and EDX to find out the nature of the Vanga Bhasma samples. The anti-microbial study was done to find out the anti-microbial efficacy of the JVB samples. Results and Conclusions: The adopted method for preparation of JVB was able to produce a Bhasma compatible to organoleptic parameters mentioned in the ancient texts. The obtained JVB was grayish white with the formation of the small sized particles as small as a nanoparticle which was confirmed by SEM study. XRD study confirms that Tin oxide is the major compound found in all the JVB samples. JVB showed antimicrobial activity in inhibiting the growth of Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumonia, Escherichia coli and Candida albicans with a concentration of 100mg/ml. The mean zone of inhibition was 12.33mm, 12.33mm, 14.66mm, 10.33mm and 16mm respectively. This outcome further supports the Krumighna and Jantughna properties (Anti-microbial activity) of Vanga Bhasma. Hence, JVB is said to possess Anti-Microbial activity.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"59 1","pages":"61-71"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86460052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-14DOI: 10.7897/2277-4572.102200
Rajani Singh, S. Rath
Cassia fistula, also known as golden shower, is a plant with many medicinal uses being used for various therapeutic purposes. It is also known by name Aaragvadha, which means “disease killer”. Its leaves, fruits and flowers are known to have medicinal relevance in Ayurveda. The fruit pulp is known to have laxative properties. It has many health benefits due to its constituents of variety of biologically active compounds those have various medicinal properties in its different part. Amaltaas is a potential medicine when used in Ekal form as well as in compound formulations. Since ancient times, it has been used in different traditional system of medicines for various ailments. This article aims to provide a comprehensive review on the use of Amaltaas as an Ekal Dravya for treating many ailments like diabetes, hematemesis, leucoderma, pruritis, intestinal disorders, as an antipyretic, analgesic and laxative. Amaltaas is being used as a one of the best prescribed remedy for many of the common ailments in day today’s life by large number of physicians. Using Amaltaas as a single dravya with various anupaan may results in optimum health benefit. Ekal dravya concept of using single substances has been mentioned in our ancient Ayurvedic literature. Use of amaltaas as a single drug therapy has been evidenced at various instances in Brihatrayee which is being reviewed in this article. Using Amaltaas as an ekal dravya and with other medicinal substances as an anupaan is also been considered and taken for the review.
{"title":"A REVIEW ON AMALTAAS (CASSIA FISTULA LINN.) AS AN EKAL DRAVYA CHIKITSA IN BRIHATRAYEE","authors":"Rajani Singh, S. Rath","doi":"10.7897/2277-4572.102200","DOIUrl":"https://doi.org/10.7897/2277-4572.102200","url":null,"abstract":"Cassia fistula, also known as golden shower, is a plant with many medicinal uses being used for various therapeutic purposes. It is also known by name Aaragvadha, which means “disease killer”. Its leaves, fruits and flowers are known to have medicinal relevance in Ayurveda. The fruit pulp is known to have laxative properties. It has many health benefits due to its constituents of variety of biologically active compounds those have various medicinal properties in its different part. Amaltaas is a potential medicine when used in Ekal form as well as in compound formulations. Since ancient times, it has been used in different traditional system of medicines for various ailments. This article aims to provide a comprehensive review on the use of Amaltaas as an Ekal Dravya for treating many ailments like diabetes, hematemesis, leucoderma, pruritis, intestinal disorders, as an antipyretic, analgesic and laxative. Amaltaas is being used as a one of the best prescribed remedy for many of the common ailments in day today’s life by large number of physicians. Using Amaltaas as a single dravya with various anupaan may results in optimum health benefit. Ekal dravya concept of using single substances has been mentioned in our ancient Ayurvedic literature. Use of amaltaas as a single drug therapy has been evidenced at various instances in Brihatrayee which is being reviewed in this article. Using Amaltaas as an ekal dravya and with other medicinal substances as an anupaan is also been considered and taken for the review.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"8 1","pages":"29-31"},"PeriodicalIF":0.0,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85446988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-14DOI: 10.7897/2277-4572.102203
Pratik Mitra, D. G. Rana
A possible association between cholesterol, cholesterol-lowering drug therapy and depression remains an issue of debate. Cholesterol-lowering drugs in general help to control elevated levels of different forms of lipids in patients with hyper-lipidemia. The present review demonstrated that recent research describes the idea that cholesterol can play an important role in governing depression. In this review, several topics such as lipid parameters and central nervous system disorders, lipid parameters and depression, lipid parameters and suicidal attempts, antidepressant effects of cholesterol lowering drugs, cholesterol lowering effects of antidepressants have been discussed. Deepening the studies in this field could be a promising avenue for future research, with implications for treating people with hypercholesterolemia along with depression.
{"title":"ROLE OF CHOLESTEROL & CHOLESTEROL LOWERING DRUGS IN DEPRESSION: A REVIEW","authors":"Pratik Mitra, D. G. Rana","doi":"10.7897/2277-4572.102203","DOIUrl":"https://doi.org/10.7897/2277-4572.102203","url":null,"abstract":"A possible association between cholesterol, cholesterol-lowering drug therapy and depression remains an issue of debate. Cholesterol-lowering drugs in general help to control elevated levels of different forms of lipids in patients with hyper-lipidemia. The present review demonstrated that recent research describes the idea that cholesterol can play an important role in governing depression. In this review, several topics such as lipid parameters and central nervous system disorders, lipid parameters and depression, lipid parameters and suicidal attempts, antidepressant effects of cholesterol lowering drugs, cholesterol lowering effects of antidepressants have been discussed. Deepening the studies in this field could be a promising avenue for future research, with implications for treating people with hypercholesterolemia along with depression.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"10 1","pages":"43-47"},"PeriodicalIF":0.0,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72778482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-14DOI: 10.7897/2277-4572.102206
J. Nesalin, Shafiya Khanum
The main objective of this research is to evaluate a new approach for the preparation of bio adhesive microparticles and to design an innovative vaginal delivery system for curcumin which is able to enhance the drug anticancer activity. Curcumin encapsulated microspheres were prepared by solvent evaporation method. The microspheres were found to be discrete, spherical with free-flowing properties and evaluated for particle size analysis, shape (scanning electron microscopy), drug encapsulation efficiency, FTIR, DSC studies and in vitro release performance. The best selected microsphere formulation (F2, containing drug: polymer ratio 1:2) was incorporated into gels with a bio adhesive polymer. The microencapsulated vaginal gels were evaluated for pH, spreadability, extrudability, viscosity, in vitro drug release, drug release kinetics, bio adhesion test, accelerated stability of selected gel formulation. In vitro drug release rate for selected microencapsulated bio adhesive vaginal gel (FS3 gel, containing 1 % w/w of drug loaded microspheres and 0.6 % w/w of Carbopol 934) was found to sustain curcumin over 12h. The results were then compared statistically and obtained a satisfactory correlation. Thus, in conclusion preparation protocol of microencapsulated vaginal gel study may be adopted for a successful development of newer drug delivery system of other drugs for administration to vagina.
{"title":"CURCUMIN LOADED POLYMERIC MICROSPHERES FOR VAGINAL DELIVERY: FORMULATION DESIGN, IN VITRO EVALUATION, KINETICS AND STABILITY STUDIES","authors":"J. Nesalin, Shafiya Khanum","doi":"10.7897/2277-4572.102206","DOIUrl":"https://doi.org/10.7897/2277-4572.102206","url":null,"abstract":"The main objective of this research is to evaluate a new approach for the preparation of bio adhesive microparticles and to design an innovative vaginal delivery system for curcumin which is able to enhance the drug anticancer activity. Curcumin encapsulated microspheres were prepared by solvent evaporation method. The microspheres were found to be discrete, spherical with free-flowing properties and evaluated for particle size analysis, shape (scanning electron microscopy), drug encapsulation efficiency, FTIR, DSC studies and in vitro release performance. The best selected microsphere formulation (F2, containing drug: polymer ratio 1:2) was incorporated into gels with a bio adhesive polymer. The microencapsulated vaginal gels were evaluated for pH, spreadability, extrudability, viscosity, in vitro drug release, drug release kinetics, bio adhesion test, accelerated stability of selected gel formulation. In vitro drug release rate for selected microencapsulated bio adhesive vaginal gel (FS3 gel, containing 1 % w/w of drug loaded microspheres and 0.6 % w/w of Carbopol 934) was found to sustain curcumin over 12h. The results were then compared statistically and obtained a satisfactory correlation. Thus, in conclusion preparation protocol of microencapsulated vaginal gel study may be adopted for a successful development of newer drug delivery system of other drugs for administration to vagina.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"38 1","pages":"56-60"},"PeriodicalIF":0.0,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75663035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-14DOI: 10.7897/2277-4572.102205
Prajakta P Shinde, Shahu D Khule, S. Sonawane, Suvarna J. Shelke
Since ancient times in India several medicinal plants are in use for clinical practices. Inflammation is a process through which the body's white blood cells and the things they make protect body from infection from outside invaders, such as bacteria and viruses. Currently many of the plant’s species have been reported effective as an Anti-inflammatory, but only a few of them have been investigated. Currently many drugs are available to control the inflammation but has several adverse effects. The plant Sida Cordata was reported to have several activities such as Antioxidant, Analgesic, Antidepressant, Antihyperglycemic, Hepatoprotective Antibacterial, Antitumor, Antifungal, Antiulcer, Antitussive, Anti-inflammatory, Anti-malarial, in ayurvedic system of medicine. This study was undertaken to investigate the anti-inflammatory activity of Methanolic extract of Sida Cordata. The methanolic extract of Sida Cordata used for treatment of Carrageenan-induced Rat paw Oedema model with the predefined dose as reported. The experimental groups with higher dose of methanolic extract (200 mg/kg) exhibited a significant anti-inflammatory effect after 2 hr. (p<0.01); based on the observation, the activity was favorable, which is nearly equal to that of the standard drug Indomethacin (10 mg/kg). The methanol extract (200 mg/kg) shows the maximum percentage of inhibition of inflammation 27.06 %. The standard drug indomethacin shows 33 % inhibition.
{"title":"ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF PLANT SIDA CORDATA IN CARRAGEENAN-INDUCED PAW EDEMA IN RATS","authors":"Prajakta P Shinde, Shahu D Khule, S. Sonawane, Suvarna J. Shelke","doi":"10.7897/2277-4572.102205","DOIUrl":"https://doi.org/10.7897/2277-4572.102205","url":null,"abstract":"Since ancient times in India several medicinal plants are in use for clinical practices. Inflammation is a process through which the body's white blood cells and the things they make protect body from infection from outside invaders, such as bacteria and viruses. Currently many of the plant’s species have been reported effective as an Anti-inflammatory, but only a few of them have been investigated. Currently many drugs are available to control the inflammation but has several adverse effects. The plant Sida Cordata was reported to have several activities such as Antioxidant, Analgesic, Antidepressant, Antihyperglycemic, Hepatoprotective Antibacterial, Antitumor, Antifungal, Antiulcer, Antitussive, Anti-inflammatory, Anti-malarial, in ayurvedic system of medicine. This study was undertaken to investigate the anti-inflammatory activity of Methanolic extract of Sida Cordata. The methanolic extract of Sida Cordata used for treatment of Carrageenan-induced Rat paw Oedema model with the predefined dose as reported. The experimental groups with higher dose of methanolic extract (200 mg/kg) exhibited a significant anti-inflammatory effect after 2 hr. (p<0.01); based on the observation, the activity was favorable, which is nearly equal to that of the standard drug Indomethacin (10 mg/kg). The methanol extract (200 mg/kg) shows the maximum percentage of inhibition of inflammation 27.06 %. The standard drug indomethacin shows 33 % inhibition.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"76 1","pages":"53-55"},"PeriodicalIF":0.0,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85737453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-14DOI: 10.7897/2277-4572.102201
A. Belge, Raman S. Belge
Abhayanga is one of the foremost massage maneuvers mentioned in the Ayurvedic texts like Brihattrayi and Laghutrayi. It is the oldest technique for healing, preventing diseases and promoting health. It has been included in the Dinacharya and also as the treatment measure for a variety of diseases. It is also a part of the pre-therapeutic procedures of Panchakarma. Abhyanga improves blood circulation (arterial as well as venous), lymphatic flow and thus offers nourishment to the body cells. It not only de-stresses the whole body but also strengthens the nervous system, improves blood circulation, removes toxins and improves the overall well-being of the person. Besides offering an immuno-modulatory action, it improves the quality of life thus benefitting the persons of all the ages. The ancient Ayurvedic literature as well as modern references was referred to have a critical study of the classification of massage; to compare between Abhyanga and Massage; to study the mode of action according to Ayurvedic and modern view. This being the Bahiparimarjana Chikitsa plays a vital role in improving the quality of life, thus fulfilling the basic motto of Ayurveda. Modern studies have proven that, Abhyanga has potential psychogenic and physiologic benefits. It can certainly be said that Abhyanga, “Adds life to years” rather than “Years to life” and thus bears a strong contemporary relevance. This review article is meant to have a critical review of Abhyanga with special reference to its contemporary relevance.
{"title":"A CRITICAL REVIEW OF ABHYANGA WITH SPECIAL REFERENCE TO ITS CONTEMPORARY RELEVANCE","authors":"A. Belge, Raman S. Belge","doi":"10.7897/2277-4572.102201","DOIUrl":"https://doi.org/10.7897/2277-4572.102201","url":null,"abstract":"Abhayanga is one of the foremost massage maneuvers mentioned in the Ayurvedic texts like Brihattrayi and Laghutrayi. It is the oldest technique for healing, preventing diseases and promoting health. It has been included in the Dinacharya and also as the treatment measure for a variety of diseases. It is also a part of the pre-therapeutic procedures of Panchakarma. Abhyanga improves blood circulation (arterial as well as venous), lymphatic flow and thus offers nourishment to the body cells. It not only de-stresses the whole body but also strengthens the nervous system, improves blood circulation, removes toxins and improves the overall well-being of the person. Besides offering an immuno-modulatory action, it improves the quality of life thus benefitting the persons of all the ages. The ancient Ayurvedic literature as well as modern references was referred to have a critical study of the classification of massage; to compare between Abhyanga and Massage; to study the mode of action according to Ayurvedic and modern view. This being the Bahiparimarjana Chikitsa plays a vital role in improving the quality of life, thus fulfilling the basic motto of Ayurveda. Modern studies have proven that, Abhyanga has potential psychogenic and physiologic benefits. It can certainly be said that Abhyanga, “Adds life to years” rather than “Years to life” and thus bears a strong contemporary relevance. This review article is meant to have a critical review of Abhyanga with special reference to its contemporary relevance.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"75 1","pages":"32-37"},"PeriodicalIF":0.0,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86154994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-14DOI: 10.7897/2277-4572.102204
J. Nesalin, N PreethiRajM
The main objective of this research is to evaluate a new approach for the preparation of bio adhesive nanoparticles and to design an innovative topical delivery system for curcumin which is able to enhance the drug anticancer activity. Curcumin encapsulated nanoparticles were prepared by ionic gelation method. The nanoparticles were found to be discrete, spherical with free-flowing properties and evaluated for particle size analysis, shape (scanning electron microscopy), drug encapsulation efficiency, FTIR, DSC studies and in vitro release performance. The best selected nanoparticles formulation (FS5, containing drug: polymer ratio 1:5) was incorporated into gels with a bio adhesive polymer. The Nanoencapsulated topical gels were evaluated for pH, spreadability, extrudability, viscosity, in vitro drug release, drug release kinetics, bio adhesion test, accelerated stability of selected gel formulation. In vitro drug release rate for selected Nanoencapsulated bio adhesive topical gel (FS3 gel, containing 1 % w/w of drug loaded nanoparticles and 0.6 % w/w of Carbopol 934) was found to control curcumin release over 12h. The results were then compared statistically and obtained a satisfactory correlation. Thus, in conclusion preparation protocol of Nanoencapsulated topical gel study may be adopted for a successful delivery of Curcumin for topical use.
{"title":"CURCUMIN LOADED CHITOSAN NANOPARTICLES FOR TOPICAL DELIVERY: FORMULATION DESIGN, IN VITRO EVALUATION, KINETICS AND STABILITY STUDIES","authors":"J. Nesalin, N PreethiRajM","doi":"10.7897/2277-4572.102204","DOIUrl":"https://doi.org/10.7897/2277-4572.102204","url":null,"abstract":"The main objective of this research is to evaluate a new approach for the preparation of bio adhesive nanoparticles and to design an innovative topical delivery system for curcumin which is able to enhance the drug anticancer activity. Curcumin encapsulated nanoparticles were prepared by ionic gelation method. The nanoparticles were found to be discrete, spherical with free-flowing properties and evaluated for particle size analysis, shape (scanning electron microscopy), drug encapsulation efficiency, FTIR, DSC studies and in vitro release performance. The best selected nanoparticles formulation (FS5, containing drug: polymer ratio 1:5) was incorporated into gels with a bio adhesive polymer. The Nanoencapsulated topical gels were evaluated for pH, spreadability, extrudability, viscosity, in vitro drug release, drug release kinetics, bio adhesion test, accelerated stability of selected gel formulation. In vitro drug release rate for selected Nanoencapsulated bio adhesive topical gel (FS3 gel, containing 1 % w/w of drug loaded nanoparticles and 0.6 % w/w of Carbopol 934) was found to control curcumin release over 12h. The results were then compared statistically and obtained a satisfactory correlation. Thus, in conclusion preparation protocol of Nanoencapsulated topical gel study may be adopted for a successful delivery of Curcumin for topical use.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"10 1","pages":"48-52"},"PeriodicalIF":0.0,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88665316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：