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Metabolic Considerations Regarding Age-related Macular Degeneration (AMD):A Focus on Current Knowledge Effects of Caloric Restriction (CR): A Review 关于年龄相关性黄斑变性(AMD)的代谢考虑:关注当前热量限制(CR)的知识效应:综述
Pub Date : 2021-01-01 DOI: 10.35248/2155-9600.21.11.804
V. Velluti, L. Gagliardi, S. Santini, Gaia Anselmi, B. Aquilanti, G. Matera, G. Egidi, S. Leone, Aless, R. Giraldi, Giacinto Abele DonatoMiggiano, A. Minnella, B. Falsini
In Western countries, AMD (Age-Related Macular Degeneration) is the leading cause of blindness in individuals over the age of 55. AMD is one of the most severe pathologies affecting the eye; in fact it damages the macula causing a serious impairment of the central vision. There are two forms of AMD: early or dry AMD and advanced AMD, which can occur as an atrophic form (geographical atrophy) or as a wet or exudative (neovascular) form (10%-15% of cases), less frequent but more disabling. Many studies on mouse models have shown that caloric restriction (CR) decreases age-related decline of ocular functions by reducing oxidative stress. It is therefore potentially useful in modulating the endophenotype of individual AMD patients This type of intervention could also be effective in humans, but being not easily applicable, it has not yet been studied extensively in the clinical setting. However, it is now known that CR mimetics can have similar benefits as CR. To allow for the wide application of the benefits of CR in the clinical setting, mimetic compounds will be developed including the activators of sirtuins and adenosine monophosphateactivated protein kinase (AMPK). Even the ketogenic diet seems to have a protective role on retinal neurodegeneration, but the data supporting this notion in the literature are still few. Finally, the role of the low glycemic index diet should not be underestimated. Extensive studies on a large population of patients must be conducted to demonstrate the effectiveness of CR, CR mimetics, ketogenic diet or simply reduction of the glycemic index of the diet on the AMD prevention and/or progression.
在西方国家,AMD(老年性黄斑变性)是55岁以上人群失明的主要原因。黄斑变性是影响眼睛最严重的病变之一;事实上,它会损害黄斑,导致中央视力严重受损。AMD有两种形式:早期或干性AMD和晚期AMD,可表现为萎缩性形式(地理萎缩)或湿性或渗出性(新生血管)形式(10%-15%的病例),发病率较低,但致残性较强。许多对小鼠模型的研究表明,热量限制(CR)通过减少氧化应激来减少与年龄相关的眼功能下降。因此,它在调节个体AMD患者的内表型方面可能是有用的。这种类型的干预也可能对人类有效,但由于不容易应用,尚未在临床环境中进行广泛研究。然而,现在已知CR模拟物可以具有与CR相似的益处。为了在临床环境中广泛应用CR的益处,将开发模拟化合物,包括sirtuins的激活剂和单磷酸腺苷活化蛋白激酶(AMPK)。甚至生酮饮食似乎对视网膜神经变性也有保护作用,但文献中支持这一观点的数据仍然很少。最后,低血糖指数饮食的作用不容小觑。必须对大量患者进行广泛的研究,以证明CR、CR模拟物、生酮饮食或单纯降低饮食的血糖指数对AMD预防和/或进展的有效性。
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引用次数: 0
Cyclic Voltammetric (CV) Evaluation of Electro chemical Behaviors of K3 [Fe (CN)6 ] and Uric Acid 循环伏安法评价K3 [Fe (CN)6]和尿酸的电化学行为
Pub Date : 2021-01-01 DOI: 10.35248/2155-9600.21.11.808
Siyum Shewakena Beshahwored
Cyclic Voltammetry has a multipurpose electroanalytical technique for the study of electroactive species, the method displays redox behaviour of chemical species inside a wide range potential. The current at the working electrode is observed as a three-cornered excitation potential is applied to the electrode. The purpose of this paper was to determine the diffusion coefficient (D) of the K3 [Fe(CN)6 ] and uric acid; electrochemical nature of K3 [Fe(CN)6 ] and uric acid, effects of varying the concentrations analytes on peak currents and peak splitting and scan rate CV on peak currents and peak splitting. All the reagents used for this experiment were analytical grade. K3 [Fe(CN)6 ] and uric acid solutions were prepared. The experiment has been implemented with the principles of cyclic voltammetry. The relationship between the scan rate and the peak current were investigated and the result shows that there is a direct relationship between scan rate and peak current that is Ipα V1/2. As articulated on the above voltammograms, the peak current increases with the augmentation of the concentrations of K3 [Fe(CN)6 ], So that, the researcher conclude the manifestation of direct relationship between peak current and concentration of analytes. The experiment of this research shows that the increasing of diffusion coefficient (D) with increasing of concentrations /and scan rate.The peak currents and peak splitting fluctuate with variation of scan rate of CV. Similarly, the peak currents and peak splitting vacillate with variation of concentration of the analytes.CV therefore can be used as an indication of major analytical tool for the determination of the trace elements which are electro active in nature. The electrochemical nature of K3 [Fe(CN)6 ] and uric acid were determined; reversible and irreversible respectively.
循环伏安法是一种多用途的电分析技术,用于研究电活性物质,该方法显示了化学物质在宽电位范围内的氧化还原行为。当对电极施加一个三角形激励电位时,观察工作电极上的电流。本文的目的是测定K3 [Fe(CN)6]与尿酸的扩散系数(D);K3 [Fe(CN)6]和尿酸的电化学性质、不同分析物浓度对峰电流和峰分裂的影响以及扫描速率CV对峰电流和峰分裂的影响。本实验所用试剂均为分析级试剂。制备了K3 [Fe(CN)6]和尿酸溶液。实验是用循环伏安法原理进行的。研究了扫描速率与峰值电流之间的关系,结果表明扫描速率与峰值电流之间存在直接关系,即Ipα V1/2。从以上伏安图可以看出,峰值电流随着K3 [Fe(CN)6]浓度的增加而增加,由此得出峰值电流与分析物浓度之间存在直接关系的表现。本研究的实验表明,扩散系数(D)随浓度和扫描速率的增加而增加。峰值电流和峰值分裂随CV扫描速率的变化而波动。同样,峰值电流和峰值分裂随分析物浓度的变化而波动。因此,CV可作为测定自然界中电活性微量元素的指示性主要分析工具。测定了K3 [Fe(CN)6]和尿酸的电化学性质;可逆的和不可逆的。
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引用次数: 1
Overview on Journal of Nutrition and Food Sciences 营养与食品科学杂志综述
Pub Date : 2021-01-01 DOI: 10.35248/2155-9600.21.11.E03
N. Jones
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引用次数: 0
Correlation between Amylase Activity and Reducing Sugar Content in Date Fruits: A Case of Increased Amylase Activity with a Proportional Increase in Reducing-Sugar Content of Fruits 枣果实中淀粉酶活性与还原糖含量的关系:淀粉酶活性随果实还原糖含量的比例增加而增加
Pub Date : 2020-01-01 DOI: 10.35248/2155-9600.20.10.767
S.S.M. Alqarni
Background: Date palm is considered as one of the essential fruits across various Arab countries, particularly in Saudi Arabia. The physical and chemical composition of the date fruits in different cultivars has been reported in many countries. The study aimed to assess the correlation between amylase activity & reducing sugar content in date fruits. It also aims to analyze the increase in amylase activity with the proportional increase in the reducing-sugar content. Methods: Qualitative analysis was used to evaluate the correlation between amylase activity & reducing sugar content in date fruits. Biochemical changes associated with the ripening of four different varieties of date fruits: sukkari, hilwa, sullaj, and khalas were examined. Results: The analysis showed that ripening of date fruits increased sugar content and enzyme activities. Correlation between amylase activity & reducing sugar content in date fruits was initially observed in Khalas and then in other varieties of date fruit. The ripening of all fruits was consistent in all date fruits varieties examined through the analysis exhibited considerable variations. The induction of amylase activity showed chronological and quantitative variations among date varieties. Conclusion: It suggests that biochemical attributes of the date palm must be considered for its expanded cultivation.
背景:枣椰树被认为是许多阿拉伯国家的重要水果之一,特别是在沙特阿拉伯。不同品种枣果实的理化成分在许多国家都有报道。研究了枣果实中淀粉酶活性与还原糖含量的关系。还分析了淀粉酶活性随还原糖含量的增加而增加的规律。方法:采用定性分析的方法,对枣果实中淀粉酶活性与还原糖含量的关系进行评价。研究了四种不同品种的枣果实:sukkari、hilwa、sullaj和khalas成熟时的生化变化。结果:枣果实成熟后,其糖含量和酶活性均有所增加。在卡拉斯和其他品种的枣果实中首先观察到淀粉酶活性与还原糖含量之间的相关性。所有水果的成熟都是一致的,通过分析检查的所有枣子品种都表现出相当大的差异。不同枣品种间淀粉酶活性的诱导表现出时间和数量上的差异。结论:扩大种植应充分考虑枣椰树的生化特性。
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引用次数: 0
Food, Packaging & Public Health 食品、包装与公共卫生
Pub Date : 2020-01-01 DOI: 10.35248/2155-9600.20.10.E002
B. Hayden.
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引用次数: 0
Effect of Low-Sugar and High-Dietary Fiber Noodles Diet on Blood Glucose Levels in Spontaneously Diabetic Torii Fatty Rats 低糖高膳食纤维面条对自发性糖尿病Torii脂肪大鼠血糖水平的影响
Pub Date : 2020-01-01 DOI: 10.35248/2155-9600.20.10.777
K. Suruga, Tsuyoshi Tomita, K. Kadokura
Background: Low-carbohydrate diets have been a popular nutrition therapy since the American Diabetes Association’s 2013 recommendation. Low-carbohydrate diets are effective at lowering blood glucose and hemoglobin A1c levels. Here, we suggested the new diets intake restriction methods using low-sugar, high-dietary fiber noodles for those consuming noodles regularly. This study aimed to investigate the effect of a 28 day low-sugar, high-dietary fiber noodles diet, containing okara and konjac, on blood glucose levels of Spontaneously Diabetic Torii fatty rats, a model for obese type 2 diabetes. Methods: Male, 7-week-old rats were divided into two groups. Group I was fed the AIN-93G as standard diet (n=6) as control group, and group II was fed the standard diet in which 50% dried low-sugar, high-dietary fiber noodles replaced cornstarch (n=6). Body weight, food intake, and blood glucose levels were measured once a week, and hemoglobin A1c and glycated albumin levels analyzed after 28 days administration. Following the 28 days, the rats were fasted, glucose (2,000 mg/kg body weight) was administrated for the oral glucose tolerance test. Results: The blood glucose, hemoglobin A1c, and glycated albumin levels of the low-sugar, high-dietary fiber noodles group were significantly lower than those of the control group, in which body weight gain was observed. Conclusion: This is the first report on the effectiveness of low-sugar, high-dietary fiber noodles on blood glucose levels in model rats. The low-sugar, high-dietary fiber noodles might be beneficial for diabetes or celiac disease patients who consume noodles.
背景:自2013年美国糖尿病协会推荐以来,低碳水化合物饮食一直是一种流行的营养疗法。低碳水化合物饮食对降低血糖和糖化血红蛋白水平有效。在此,我们建议经常吃面条的人使用低糖、高膳食纤维的面条作为新的饮食限制方法。本研究旨在探讨28天低糖、高膳食纤维面条(含有冈菜和魔芋)对肥胖型2型糖尿病模型——自发性糖尿病Torii脂肪大鼠血糖水平的影响。方法:7周龄雄性大鼠分为两组。ⅰ组以AIN-93G为标准饲粮(n=6)作为对照组,ⅱ组以50%的低糖高膳食纤维干面代替玉米淀粉为标准饲粮(n=6)。每周测量一次体重、食物摄入量和血糖水平,并在给药28天后分析血红蛋白A1c和糖化白蛋白水平。28 d后,大鼠禁食,给予葡萄糖(2000 mg/kg体重)进行口服葡萄糖耐量试验。结果:低糖高膳食纤维面条组的血糖、糖化血红蛋白、糖化白蛋白水平均显著低于对照组,且有体重增加。结论:本文首次报道了低糖高膳食纤维面条对模型大鼠血糖水平的影响。这种低糖、高膳食纤维的面条可能对糖尿病或乳糜泻患者有益。
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引用次数: 2
Prevention of Current Viral (COVID-19) Infection and Future Outbreak by Modulating Dietary Habit and Life Style 通过调节饮食习惯和生活方式预防当前病毒(COVID-19)感染和未来爆发
Pub Date : 2020-01-01 DOI: 10.35248/2155-9600.20.10.776
F. LukmanulHakkim, H. Bakshi
The outbreak of COVID-19 started in Wuhan, china in December 2019. Since then this outbreak causes significant loss of life and sever economic crisis around the world. People who are older than 60 years of age and having clinical conditions such as high blood pressure, diabetes, and low immune system suffered a lot due to this pandemic. Out of these whole scenarios we understand common criteria that those who have stronger immune system they would be able to fight this disease and recover. Enormous literature states that maintaining healthier life style would significantly improve immune system performance and this will prevent infection of uncertain virus outbreaks. Further dietary agents such as garlic, ginger, turmeric, lemon, cinnamon, black seed, and pepper etc has enormous potential to keep immune system stronger. Changing the modern life style such as eating junk foods, improper sleep, lack of exercise etc. would diminish the activity of immune system and these habits makes system more vulnerable to virus infections. Here we propose that adopting a life style with natural ingredients, regular exercise, remain hydrated would significantly enhance the immune system function.
新冠肺炎疫情于2019年12月在中国武汉爆发。自那时以来,这次疫情在世界各地造成重大生命损失和严重的经济危机。60岁以上、患有高血压、糖尿病、免疫系统低下等临床症状的老年人受到了很大的影响。在这些情况下,我们理解了那些免疫系统更强的人能够对抗这种疾病并康复的共同标准。大量文献表明,保持健康的生活方式将显著提高免疫系统的性能,这将防止感染不确定的病毒爆发。进一步的膳食制剂,如大蒜、生姜、姜黄、柠檬、肉桂、黑籽和胡椒等,有巨大的潜力保持免疫系统更强大。改变现代生活方式,如吃垃圾食品,睡眠不当,缺乏锻炼等,会减少免疫系统的活动,这些习惯使系统更容易受到病毒感染。在此,我们建议采用天然成分的生活方式,经常运动,保持水分,可以显著增强免疫系统功能。
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引用次数: 0
Black Rice: A Novel Ingredient in Food Processing 黑米:食品加工中的一种新原料
Pub Date : 2020-01-01 DOI: 10.35248/2155-9600.20.10.771
Nitin Kumar, R. Murali
Black rice (Zizania aquatica) is a rice variety formed by the mutation of Kala4 gene. In the world it is mainly cultivated in Southeast Asian countries like China, Thailand and India. China accounts for 62% of black rice production in the world followed by Sri Lanka, India, Indonesia and Philippines. Thailand holds the 9th position for black rice cultivation. In India black rice is grown in North-eastern states like Manipur, Mizoram, Meghalaya, Assam and some parts of Odisha. Black rice is black in color due to the presence of the anthocyanin pigment on the outer layers (bran) of the rice kernel. Black rice is rich in tocopherols (vitamin E), iron and antioxidants. Black rice has high levels of protein, fiber, vitamins (Vitamin B1, Vitamin B2, folic acid) and minerals (iron, zinc, calcium, phosphorous and selenium) compared to that of white rice. The major essential amino acids present in black rice are lysine and tryptophan. It also possesses lot of health benefits like antioxidant activity, anti-inflammatory properties, lipid oxidation, anti-diabetic, anti-ageing and anti-cancer effects. The use of black rice as an ingredient in food processing might help in creating value added products. In this paper, an attempt has been made to highlight the application of black rice as a novel ingredient in various sectors of food processing.
黑米(Zizania aquatica)是由Kala4基因突变形成的水稻品种。在世界上,它主要种植在东南亚国家,如中国、泰国和印度。中国占世界黑米产量的62%,其次是斯里兰卡、印度、印度尼西亚和菲律宾。泰国在黑米种植方面排名第九。在印度,黑米种植在东北部的曼尼普尔邦、米佐拉姆邦、梅加拉亚邦、阿萨姆邦和奥里萨邦的部分地区。黑米的颜色是黑色的,因为在米粒的外层(麸皮)上存在花青素。黑米富含生育酚(维生素E)、铁和抗氧化剂。与白米相比,黑米含有高水平的蛋白质、纤维、维生素(维生素B1、维生素B2、叶酸)和矿物质(铁、锌、钙、磷和硒)。黑米中主要的必需氨基酸是赖氨酸和色氨酸。它还具有许多健康益处,如抗氧化活性、抗炎特性、脂质氧化、抗糖尿病、抗衰老和抗癌作用。在食品加工中使用黑米作为原料可能有助于创造增值产品。在本文中,试图强调黑米作为一种新的成分在食品加工的各个部门的应用。
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引用次数: 21
Effect of Pharmacologically Active Medicinal Byproduct Combination as Feed Additives on Performance, Fecal Microbiology, Hematological Parameters and Economic Efficacy in Broiler Chicken 药理活性药物副产物组合作为饲料添加剂对肉鸡生产性能、粪便微生物学、血液学参数和经济效益的影响
Pub Date : 2020-01-01 DOI: 10.35248/2155-9600.20.10.770
A. Bostami, C. Yang, R. I. Khan, M. Hossain, A. Rabbi
An experiment was conducted and designed with pharmacologically active medicinal byproduct combinations (Camelia sinensis, Aloe vera and Phylanthus emblica) as feed additives to check the impact on growth performance, fecal pH and microbiology, hematological parameters and economic efficacy in broiler chicken. A total of 240 chicks were randomly allocated to four treatments having 6 replications of 10 birds per replicated pen following completely randomized design and reared for the period of 5 weeks. Dietary treatments were: 1) MPC0=Control (basal diet without medicinal byproduct combinations); 2) MPC1=basal diet+0.2% medicinal byproduct combination; 3) MPC2=basal diet+0.4% medicinal byproduct combinations; 4) MPC3=basal diet+0.6% medicinal byproduct combination. Result of present study revealed that, medicinal byproduct combinations added groups MPC1, MPC2 and MPC3 exhibited better broiler growth performance as compared to MPC0 (P<0.05). Lower fecal pH was depicted in the MPC1, MPC2 and MPC3 inoculated birds in comparison to the MPC0 (P<0.05). Suppression of pathogenic E. coli was observed in MPC2 and MPC3 and Salmonella sp. was observed lower in MPC1, MPC2 and MPC3 supplemented birds relative to that of MPC0 (P<0.05). There was no profound negative impact on hematological parameters except lower RBC count was found in MPC2 as compared to MPC0 (P<0.05). Economic efficacy was better in case of broilers treated with MPC1, MPC2 and MPC3 compare to MPC0 (P<0.05). To sum up, medicinal byproduct combinations with Camelia sinensis, Aloe vera and Phylanthus emblica could be potential feed additives in case of broilers, where MPC2 could be preferred for better efficacy.
本试验设计以具有药理活性的药物副产物组合(山茶、芦荟和牛膝草)为饲料添加剂,考察其对肉鸡生长性能、粪便pH值、微生物学、血液学参数和经济效益的影响。试验采用完全随机设计,将240只雏鸡随机分为4个处理,每处理6个重复,每个重复栏10只,饲养5周。饲粮处理为:1)MPC0=对照组(不含药物副产物组合的基础饲粮);2) MPC1=基础日粮+0.2%药物副产物组合;3) MPC2=基础日粮+0.4%药物副产物组合;4) MPC3=基础日粮+0.6%药物副产物组合。结果表明,药用副产物组合添加MPC1、MPC2和MPC3组肉鸡生长性能优于MPC0组(P<0.05)。与MPC0相比,MPC1、MPC2和MPC3接种组的粪便pH值较低(P<0.05)。在MPC1、MPC2和MPC3中,致病性大肠杆菌受到抑制,沙门氏菌在MPC1、MPC2和MPC3中受抑制程度低于MPC0 (P<0.05)。与MPC0相比,MPC2组的红细胞计数较低(P<0.05),但对血液学参数没有明显的负面影响。MPC1、MPC2和MPC3处理肉鸡的经济效益优于MPC0 (P<0.05)。综上所述,药用副产物与山茶花、芦荟和牛毛草组合可作为肉鸡潜在的饲料添加剂,其中MPC2效果更好。
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引用次数: 0
Effect of Using Moringa oleifera and Spirulina platensis as Feed Additives on Performance, Meat Composition and Oxidative Stability and Fatty Acid Profiles in Broiler Chicken 辣木和螺旋藻饲料添加剂对肉鸡生产性能、肉成分、氧化稳定性和脂肪酸分布的影响
Pub Date : 2020-01-01 DOI: 10.35248/2155-9600.20.10.772
F. Sharmin, N. R. Sarker, Md. Sazedul Karim Sarker
A study was conducted to determine mainly the n 3 fatty acids enrichment and decreased oxidation of broiler meat using the plant Moringa oleifera and a blue green algae Spirulina platensis. The effects of the dietary treatments were evaluated in terms of growth performance, carcass and meat yields, oxidative stability and fatty acids modulation. Two hundred and forty (240) one day old Cobb 500 broiler chicks were assigned to 5 dietary treatments for 5 weeks, with 4 replications having 12 chicks per replication. The diets of the treatments were formulated from the basal feed as follows: control (T1), including 2 different levels of M. oleifera leaf meal 1% (T2) and M. oleifera leaf meal 1.5%, (T3) and 2 different levels of S. platensis 1% (T4) and S. platensis 1.5% (T5). The birds were randomly distributed in each pen, and the data were analyzed using the SPSS statistical package. The final body weight (BW) gain was significantly higher in the T2 and T5 groups, and the feed conversion ratio improved in the T2 group (1.68). The lowest (p ≤ 0.05) thiobarbituric acid-reactive substances values (TBARS) of breast and thigh were obtained in T2 groups compared to T3-T5 group after the second week of preservation. Regarding fatty acid profile of breast and thigh meat, the omega-3 fatty acid levels, such as those of linolenic and docosahexaenoic acid (DHA), were increased in the additives groups. The results of the present study elucidated that dietary inclusion of the 2 medicinal plants in the T2 and T5 groups could be promising functional ingredients to produce value-added broiler meat in terms of oxidative stability and omega-3 fatty acids enhancement.
以辣木(Moringa oleifera)和蓝绿藻螺旋藻(Spirulina platensis)为原料,对肉鸡肉中n3脂肪酸的富集和氧化程度进行了研究。从生长性能、胴体和肉产量、氧化稳定性和脂肪酸调节等方面评价饲粮处理的效果。选取240只1日龄Cobb 500肉鸡240只,分为5个饲粮处理,每组4个重复,每个重复12只鸡,连续5周。各处理的饲粮以基础饲料为基础配制如下:对照(T1),包括2个不同水平的油松叶粉1% (T2)和油松叶粉1.5% (T3)和2个不同水平的油松1% (T4)和油松1.5% (T5)。各组随机分布,数据采用SPSS统计软件包进行统计分析。T2组和T5组的末增重显著提高,饲料系数提高(1.68)。保存第2周后,T2组乳房和大腿的硫代巴比妥酸反应性物质值(TBARS)较T3-T5组最低(p≤0.05)。对于胸肉和大腿肉的脂肪酸谱,添加组的-3脂肪酸水平,如亚麻酸和二十二碳六烯酸(DHA)水平均有所增加。本研究结果表明,在T2和T5组饲粮中添加这2种药用植物可能是在氧化稳定性和增加omega-3脂肪酸方面有希望生产增值肉鸡肉的功能成分。
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引用次数: 9
期刊
Journal of Nutrition and Food Sciences
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