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Influence of Honey on Energy Metabolism during Wound Healing in Rats 蜂蜜对大鼠伤口愈合过程中能量代谢的影响
Pub Date : 2009-03-03 DOI: 10.3814/2009/715320
M. Sumitra, P. Manikandan, V. S. Gayathri, L. Suguna
The aim of this study is to find out how honey influences the activities of the enzymes involved in energy metabolism during wound healing. Carbohydrate metabolism is the main source of energy for skin cells during wound healing. Since honey is full of sugars, and hence a rich source of energy, we have investigated the efficacy of honey on energy metabolism during wound healing in rats. A total number of 48 animals were used. From these, 24 animals were divided into two groups, control and experimental. Full thickness excision wounds were made on the back of rats. The control rats were left untreated. The experimental rats received 500  μL of honey topically, once daily, for 12 days. Six animals from each group were sacrificed on different time point intervals like 4, 8, and 12 days. The remaining 12 animals were used to evaluate the contraction and epithelialization. The activities of hexokinase, phosphofructokinase glyceraldehyde-3-phosphate dehydrogense, lactate dehydrogenase, and glucose-6-phosphate dehydrogenase were measured in the granulation tissue. A marked increase in the activities of all the glycolytic enzymes in the experimental wounds when compared to control suggests that honey could provide sufficient energy for cellular activity needed for the repair process.
本研究的目的是找出蜂蜜如何影响伤口愈合过程中参与能量代谢的酶的活性。在伤口愈合过程中,碳水化合物代谢是皮肤细胞能量的主要来源。由于蜂蜜富含糖,因此是一种丰富的能量来源,我们研究了蜂蜜对大鼠伤口愈合过程中能量代谢的功效。共使用48只动物。将24只动物分为对照组和实验组。大鼠背部全层切除创面。对照大鼠不接受治疗。实验大鼠局部灌胃蜂蜜500 μL,每日1次,连用12 d。每组各取6只动物,分别于4、8、12天的不同时间点间隔处死。其余12只动物用于评估收缩和上皮化情况。测定肉芽组织中己糖激酶、磷酸果糖激酶甘油醛-3-磷酸脱氢酶、乳酸脱氢酶和葡萄糖-6-磷酸脱氢酶的活性。与对照组相比,实验伤口中所有糖酵解酶的活性都显著增加,这表明蜂蜜可以为修复过程所需的细胞活动提供足够的能量。
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引用次数: 12
Polyethism in an Oriental Hornet (Vespa orientalis) Colony 东方大黄蜂(Vespa orientalis)群体中的聚醚
Pub Date : 2009-03-03 DOI: 10.3814/2009/243436
Stanislav Volynchik, M. Plotkin, D. Bergman, J. Ishay
The present study describes the daily activities of the Oriental hornet (Vespa orientalis) workers older than 48 hours as observed in an Artificial Breeding Box (ABB) in our laboratory at the peak of the active season. These workers were picked randomly from a population of a single nest that was enabled to free egress into the field. The study points to the existence of polyethism in the nest of V. orientalis with the adult worker hornets, separating them into three groups in accordance with the frequency and nature of their exits from the nest, and the tasks which they perform. This polyethism was not age-dependent. Recordings were made of the following vespine activities: the frequency of exits to the field during various hours of the day and the various roles undertaken by the hornets. Also investigated was the assignment of tasks among the hornets and the preference given to some tasks over others. The general organization of traffic and other movements in the colony is discussed.
本研究描述了在实验室人工繁殖箱(ABB)中观察到的东方大黄蜂(Vespa orientalis)工蜂48小时以上的日常活动高峰。这些工蚁是从一个单独的巢穴中随机挑选出来的,这些巢穴可以自由地进入田野。该研究指出,东方大黄蜂与工蜂成虫的巢穴中存在聚醚,并根据它们离开巢穴的频率和性质以及它们执行的任务将它们分为三组。这种多元性与年龄无关。记录了黄蜂的活动:在一天的不同时间里,黄蜂离开场地的频率,以及它们所扮演的不同角色。研究人员还调查了大黄蜂之间的任务分配以及对某些任务的偏好。讨论了殖民地的交通和其他运动的一般组织。
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引用次数: 4
Extranodal NK/T-Cell Lymphoma without Nasal Cavity Involvement Associated with Epstein-Barr Virus: A Multimodality-Based Diagnosis of Two Cases 结外NK/ t细胞淋巴瘤不累及鼻腔与爱泼斯坦-巴尔病毒:多模态诊断为基础的两例
Pub Date : 2009-02-25 DOI: 10.3814/2009/963781
F. Cobo, Clara Chamorro, F. Ramos, A. Concha
We report two cases of extranodal NK/T-cell lymphoma, nasal type, in immunocompetent patients without nasal cavity involvement. In the two cases, the initial presumptive diagnosis was tuberculosis and there was a rapid dissemination of the tumor with short survival after the hospital admittance. An autopsy was performed showing infiltration in several organs including lymph nodes and mesenteric and retroperitoneal fat. Histological sections showed an angiocentric and angiodestructive growth pattern and the immunophenotype was CD45
我们报告两例结外NK/ t细胞淋巴瘤,鼻型,在免疫功能正常的患者没有鼻腔的侵犯。在这两个病例中,最初的推定诊断是结核病,住院后肿瘤传播迅速,生存时间短。尸检显示几个器官浸润,包括淋巴结、肠系膜和腹膜后脂肪。组织切片显示血管中心和血管破坏生长模式,免疫表型为CD45
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引用次数: 0
Enterolith Small-Bowel Obstruction Caused by Crohn's Disease 克罗恩病引起的肠石性小肠阻塞
Pub Date : 2009-02-25 DOI: 10.3814/2009/653965
Ichiro Akagi, M. Miyashita, M. Hashimoto, H. Makino, T. Nomura, N. Hagiwara, Ken Takahashi, T. Tajiri
We herein report on the successful surgical treatment of Crohn's disease with enteroliths formed in the ileum. A 58-year-old man presented with abdominal colicky pain, and long-standing constipation. He was diagnosed as ileus due to enteroliths and was initially managed conservatively, but improvement was not observed either clinically or on radio imaging. We, therefore, performed a laparotomy, which revealed Crohn's disease with enteroliths in the ileum. Because the enteroliths in the ileum were not mobile and could not be broken manually, we carried out a segmental bowel resection with the removal of the enteroliths. The pathology report revealed Crohn's disease with enteroliths. Intestinal obstruction caused by enteroliths associated with Crohn's disease occurs rarely, and is difficult to be diagnosed and managed.
我们在此报告成功的手术治疗与肠石形成的回肠克罗恩病。男,58岁,腹痛,长期便秘。他被诊断为肠结石引起的肠梗阻,最初进行了保守治疗,但无论是临床还是放射成像都没有观察到改善。因此,我们进行了剖腹手术,发现克罗恩病伴回肠肠结石。由于回肠内的肠结石不能移动,无法人工打破,我们进行了节段性肠切除术,切除了肠结石。病理报告显示克罗恩病伴肠结石。肠结石引起的肠梗阻与克罗恩病很少发生,很难诊断和管理。
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引用次数: 2
IgA Anticardiolipin in Patients with Gastroenteric Tumor 胃肠道肿瘤患者的IgA抗心磷脂
Pub Date : 2009-02-16 DOI: 10.3814/2009/641360
Ilaria Bernardini, L. Pugliese, E. Pacifico, M. Viola-Magni, E. Albi
Recently the presence of antiphospholipid antibodies in patients with cancer has been demonstrated, suggesting an involvement of autoimmune response in neoplastic conditions. The presence of antiphospholipid antibodies in tumor disease is highly correlated with the risk of developing thrombotic complications, which represents a significant cause of morbidity and mortality in cancer patients. Interestingly, it has been highlighted that high levels of IgM and IgG anticardiolipin antibodies are more often produced in patients with gastroenteric tumor than in patients with either ovarian or breast tumor. Thus far, there are no data looking into the role or measurements of IgA in patients with solid cancer. Our preliminary results, in this study, demonstrate that testing only for IgG and IgM anticardiolipin antibodies may increase the incidence of false positive because 44% who were IgA positive and IgG and IgM negative had high titres of CA19.9 and CEA. We suggest that taking into account the role of IgA could substantially improve the detection of antiphospholipids antibodies in subjects with solid cancer, and this detection may allow us for better prevention and management of thrombotic complications in these patients.
最近在癌症患者中发现了抗磷脂抗体,提示自身免疫反应参与了肿瘤的发生。肿瘤疾病中抗磷脂抗体的存在与血栓形成并发症的风险高度相关,血栓形成并发症是癌症患者发病率和死亡率的重要原因。有趣的是,有研究强调,胃肠道肿瘤患者比卵巢或乳腺肿瘤患者更常产生高水平的IgM和IgG抗心磷脂抗体。到目前为止,还没有研究IgA在实体癌患者中的作用或测量的数据。在本研究中,我们的初步结果表明,仅检测IgG和IgM抗心磷脂抗体可能会增加假阳性的发生率,因为44%的IgA阳性,IgG和IgM阴性的患者具有高滴度的CA19.9和CEA。我们认为,考虑IgA的作用可以大大提高实体癌患者抗磷脂抗体的检测,这种检测可以让我们更好地预防和管理这些患者的血栓性并发症。
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引用次数: 1
Impairment of Spatial Performance by Environmental Noise 环境噪音对空间性能的损害
Pub Date : 2009-02-16 DOI: 10.3814/2009/840620
M. Gheraat, N. Naghdi, B. Jalaei, P. Mokhtari, F. Moghadam, E. Soleimannejad, Leila. Eidi Abarghani
We examined the effects of noise on acquisition and retention of the spatial memory task in equal and unequal context in adult male rats. The natural noise in Azadi football stadium was recorded and measured by sound level meter instrument and set in high (HI), moderate (MI), and low (LI) intensities, 86, 64, and 47 decibels A (dbA), respectively. Rats were trained in Morris water maze (MWM) for 3-consecutive-day program and at day 4 visible and probe tests were done under one of the above noise intensities. The retention was evaluated at day 7 on the basis of equal and unequal noise exposure situation. Escape latency, traveled distance, and swimming speed were recorded and used for subsequent analysis. Our results showed significant increases in the escape latency and traveled distance by increasing the noise intensity during acquisition period, and also retention test in equal noise situation. Furthermore, retention test in the group that was under HI noise during both training period and retention test escape latency and traveled distance compared to the groups which was under HI noise during training period and LI or MI noise during retention test (HI-LI or HI-MI).
我们研究了噪声对成年雄性大鼠在同等和不同等环境下空间记忆任务获得和保持的影响。采用声级计对阿扎迪足球场的自然噪声进行了记录和测量,设置了高(HI)、中(MI)和低(LI)强度,分别为86、64和47分贝A (dbA)。大鼠在Morris水迷宫(MWM)中进行连续3天的训练,第4天在上述任意一种噪声强度下进行视觉和探针测试。在第7天,根据等噪声暴露和不等噪声暴露的情况来评估保留率。记录逃跑潜伏期、行进距离和游泳速度,并用于后续分析。实验结果表明,在获取过程中,增加噪声强度会显著增加逃避潜伏期和行走距离,在等噪声条件下,保留率测试也会显著增加。此外,在训练期间同时处于高噪声和保持测试下的保留测试组,与在训练期间处于高噪声和在保持测试中处于LI或MI噪声(HI-LI或HI-MI)的组相比,在保持测试期间处于高噪声和LI或MI噪声下的组逃避延迟和移动距离。
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引用次数: 1
Wide-Beam X-Ray Source Target Thermal Management Simulation Using Inner Jet Cooling 采用内喷流冷却的宽束x射线源目标热管理模拟
Pub Date : 2009-02-08 DOI: 10.3814/2009/797068
C. Kim, J. Doster, M. Bourham
A wide-beam area X-ray source has been proposed as a practical replacement for synchrotron sources in clinical DEI applications. Due to a wide X-ray illumination area, a decrease in X-ray flux is expected and thus high electron beam currents up to 3A are considered. To ensure the target performance without deterioration, melting, cracking, or even evaporation, an active cooling system is required for the target block in order to remove the heat and allow for sufficient scanning time. In this study, jet cooling of the target back is investigated for a prototype proof-of-principle target. The prototype target was simulated with the transient k- ɛ turbulence multiphysics model in ANSYS CFX. The simulations were conducted at a heat flux of 1.8 × 10 7  W/ m 2 , consistent with values anticipated for a full scale target. The simulation results show that the target temperature exceeds the copper melting point in 2 seconds at inlet velocities below 2 m/s. Also, critical heat flux calculations show that a 1.5 m/s inlet velocity at atmospheric pressure is a lower limit for prevention of target burnout using water as a coolant. Inlet velocities in excess of 2 m/s allows for steady-state operation while satisfying all thermal design constraints.
宽光束区域x射线源已被提出作为临床DEI应用中同步加速器源的实际替代品。由于x射线照射范围广,预计x射线通量会减少,因此考虑到高达3A的高电子束电流。为了确保目标性能不变质,不熔化,不开裂,甚至不蒸发,目标块需要一个主动冷却系统,以去除热量并允许足够的扫描时间。在本研究中,研究了一个原理验证的原型靶背部的射流冷却。在ANSYS CFX中采用瞬态k- ε湍流多物理场模型对原型目标进行了仿真。模拟的热流密度为1.8 × 10.7 W/ m2,与全尺度目标的预期值一致。仿真结果表明,在进口速度低于2 m/s时,目标温度在2秒内超过铜熔点。此外,临界热流密度计算表明,在常压下1.5 m/s的入口速度是防止使用水作为冷却剂的目标烧毁的下限。超过2米/秒的进口速度允许稳态运行,同时满足所有热设计约束。
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引用次数: 2
Intraosseous Epidermoid Cyst of Distal Phalanx of Fingers 手指远端指骨骨内表皮样囊肿
Pub Date : 2008-12-25 DOI: 10.3814/2008/963687
C. Hsieh, Y. Tien, S. Chien
Intraosseous epidermoid cysts of fingers are uncommon lesions. We reported two cases with intraosseous epidermoid cysts of distal phalanx of fingers. Case 1 was a 61-year-old woman with a swelling of the left middle finger without history of trauma. Case 2 was a 47-year-old male with a crushing injury of his right thumb. On radiographic findings, a well-circumscribed osteolytic lesion in distal phalanges was noted. Unexpectedly, histological examinations showed intraosseous epidermoid cyst.
手指骨内表皮样囊肿是一种罕见的病变。我们报告了2例手指远端指骨骨内表皮样囊肿。病例1为61岁女性,左中指肿胀,无外伤史。病例2为一名47岁男性,右拇指挤压伤。在x线表现上,在远端指骨处发现一界限清楚的溶骨性病变。出乎意料的是,组织学检查显示骨内表皮样囊肿。
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引用次数: 2
Could Some Black Holes Have Evolved from Wormholes 一些黑洞可能是从虫洞进化而来的吗
Pub Date : 2008-12-24 DOI: 10.3814/2008/296158
P. Kuhfittig
One way to explain the present acceleration of the universe is Einstein's cosmological constant. It is quite likely, in view of some recent studies, that a time-dependent equation of state had caused the Universe to evolve from an earlier phantom-energy model. In that case, traversable wormholes could have formed spontaneously. It is shown in this paper that such wormholes would eventually have become black holes. This would provide a possible explanation for the huge number of black holes discovered, while any evidence for the existence of wormholes is entirely missing, even though wormholes are just as good, in terms of being a prediction of general relativity, as black holes.
解释目前宇宙加速的一种方法是爱因斯坦的宇宙常数。从最近的一些研究来看,很有可能是一个与时间有关的状态方程导致了宇宙从早期的幽灵能量模型演化而来。在这种情况下,可穿越的虫洞可能会自发形成。这篇论文表明,这样的虫洞最终会变成黑洞。这将为发现的大量黑洞提供一个可能的解释,而虫洞存在的任何证据都完全缺失,尽管虫洞和黑洞一样好,就广义相对论的预测而言。
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引用次数: 11
Ground Penetrating Radar: The Electromagnetic Signal Attenuation and Maximum Penetration Depth 探地雷达:电磁信号衰减与最大穿透深度
Pub Date : 2008-12-24 DOI: 10.3814/2008/926091
G. Leucci
The use of high frequencies limits the penetration of the radar energy; this low penetration depends, at a parity of used frequencies, on the electromagnetic properties of the investigated material. The principal drawback is the elevated sensibility of the system to the variations of the EM properties of the environment immediately surrounds the antennas. The radar signals that arrive at the receiving antenna are attenuated and modified because of the selective absorption of the pulses by the ground, because of geometrical spreading, and because of an alteration of the actual amplitude due to the instrument amplification. In this paper, the absorption of the radar signal is taken into consideration and we determine, respectively, (i) the radar signal attenuation in the ground, (ii) the electrical conductivity (σ) and the relative dielectric permettivity (RDP) of the ground, and (iii) the maximum penetration depth of GPR in the ground.
高频的使用限制了雷达能量的穿透;在所用频率的宇称下,这种低穿透取决于所研究材料的电磁特性。主要缺点是系统对天线周围环境的电磁特性变化的敏感性提高。到达接收天线的雷达信号被衰减和修改,因为脉冲被地面选择性吸收,因为几何扩散,因为仪器放大导致实际幅度的改变。本文考虑雷达信号的吸收,分别确定(i)雷达信号在地面的衰减,(ii)地面的电导率(σ)和相对介电常数(RDP), (iii)探地雷达在地面的最大侵彻深度。
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引用次数: 41
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