Journal of Radiation Research and Applied Sciences最新文献

{"title":"Adoption of magnetic resonance image-based comfort nursing in patients with chronic rhinosinusitis","authors":"Jie Yang ,&nbsp;Rong Lin ,&nbsp;Jiaojiao Wu ,&nbsp;Hongyuan Zhu ,&nbsp;Lina Fang","doi":"10.1016/j.jrras.2026.102172","DOIUrl":"10.1016/j.jrras.2026.102172","url":null,"abstract":"<div><h3>Objective</h3><div>This research aimed to evaluate the clinical efficacy of magnetic resonance image (MRI)-based comfort care in patients with chronic rhinosinusitis (CRS) and analyze its impact on hospital stay, symptom relief, and nursing satisfaction.</div></div><div><h3>Methods</h3><div>A total of 300 patients with CRS who had received MRI examination to clarify the pathological features were retrospectively included and divided into a control group (n = 150) and an intervention group (n = 150) based on the nursing protocol they received. The control group received routine nursing care. While the intervention group received additional comfort care interventions (psychological support, posture guidance, dietary management) that were personalized based on individual MRI characteristics such as mucosal thickening and sinus obstruction. The data of hospital stay, time to complication resolution, medication/lifestyle/diet compliance score, and nursing satisfaction of the two groups were collected retrospectively and statistically analyzed.</div></div><div><h3>Results</h3><div>Based on MRI characteristics (e.g.<em>,</em> mucosal thickening, calcifications), the intervention group received personalized care tailored to lesion severity and location. Their hospital stay (9.85 ± 1.63 days) and time to complication resolution (8.17 ± 1.29 days) were notably shorter than those of the control group (16.18 ± 2.24 days, 15.09 ± 1.83 days, <em>P</em> &lt; 0.05). MRI assessment revealed that patients with more extensive inflammation received more targeted interventions, which was associated with higher compliance scores (r = −0.42, <em>P</em> &lt; 0.05), suggesting imaging helped tailor effective care. The intervention group exhibited greatly higher medication, lifestyle, and dietary compliance scores (23.71 ± 4.39, 24.31 ± 4.62, 21.93 ± 3.67) versus the control group (15.85 ± 5.05, 15.23 ± 3.77, 14.88 ± 4.55, <em>P</em> &lt; 0.05). Nursing satisfaction was also markedly higher in the intervention group (90.67 %) than in the control group (76.67 %, <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This retrospective analysis showed that MRI-based comfort care enables precise disease assessment and personalized interventions, effectively reducing hospital stay, improving treatment compliance, and enhancing nursing satisfaction in CRS patients, demonstrating promising clinical value that warrants further investigation and validation.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102172"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147394340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Hamilton-crosser thermal conductivity model in the quaternary nanofluid flow with second-order slip condition","authors":"Hazirah Mohd Azmi ,&nbsp;Norihan Md Arifin ,&nbsp;Haliza Rosali ,&nbsp;Siti Suzilliana Putri Mohamed Isa","doi":"10.1016/j.jrras.2025.102142","DOIUrl":"10.1016/j.jrras.2025.102142","url":null,"abstract":"<div><div>Nanofluids, formed by dispersing nanoparticles into conventional base fluids, have gained significant attention as advanced heat transfer media in various sectors, including automotive, aerospace, nuclear reactors, biomedical systems, etc. Their enhanced thermophysical properties and particularly improved thermal conductivity, which make them superior to traditional fluids for high-efficiency thermal management. To accurately estimate the thermal conductivity of nanofluids, several theoretical models have been proposed, among which the Hamilton-Crosser (HC) model is widely adopted. This model extends Maxwell's classical theory by incorporating particle shape factors, providing more accurate predictions for fluids containing non-spherical or clustered nanoparticles. In the field of fluid mechanics, boundary layer flows influenced by magnetohydrodynamics (MHD) and thermal radiation are of increasing relevance in systems subjected to magnetic fields and high heat loads, such as in magnetic cooling, plasma processing and solar energy applications. According to this problem statement, this paper provides a numerical solution for the mathematical modelling of the MHD radiative water-based nanofluid flow. This nanofluid contains a combination of four nanoparticles: alumina, copper, graphene and silicon dioxide, which represents a quaternary hybrid nanofluid system. The mathematical modelling was initiated with the partial differential equations (PDEs) and finalised by ordinary differential equations (ODEs). The transformations from PDEs to ODEs simplify the mathematical model for numerical analysis, which can be done by using similarity transformations. The resulting ODEs are solved using MATLAB's built-in bvp4c solver. Key physical quantities for the profiles (velocity and temperature) and the quantities measured for the flow and thermal characteristics (skin friction coefficient and local Nusselt number) are graphically illustrated and described. The results show that the quaternary case produces the highest heat transfer rate compared to the nanofluid case, which has the lowest number of nanoparticle types (nanofluid case). In addition, the cylindrical shape is proven to have the highest local Nusselt number value for the stretching boundary case, while the spherical shape produces the highest local Nusselt number value for the shrinking boundary. Meanwhile, the magnetic field, thermal radiation, slip condition and projected angle at the sheet influence the distribution of the profile and physical parameters.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102142"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coptisine suppresses pulmonary nodule carcinogenesis by inducing CAFs mitochondrial apoptosis via Sirt3/YME1L1","authors":"Jin-Liang Hu ,&nbsp;Kun Lv ,&nbsp;Jie-Zhong Hu ,&nbsp;Zheng Tang ,&nbsp;Pia Vanessa C. Basilio","doi":"10.1016/j.jrras.2025.102148","DOIUrl":"10.1016/j.jrras.2025.102148","url":null,"abstract":"<div><div>Coptisine, an active alkaloid from <em>Coptis chinensis</em>, exhibits potent anticancer effects by targeting cancer-associated fibroblasts (CAFs) in the tumor microenvironment. This study investigates its mechanism in attenuating lung via Sirt3-mediated deacetylation of YME1L1, regulating mitochondrial apoptosis in CAFs. Orthotopic lung cancer models were established in C57BL/6 mice using SCLC-2 cells, treated with Coptisine (60 or 120 mg/kg/day). In vitro, primary pulmonary fibroblasts (CAFs) co-cultured with SCLC-2 cells were assessed for proliferation (CCK-8), metastasis (Transwell), apoptosis (ELISA), mitochondrial potential (JC-1), and ROS (DCFH-DA). Coptisine inhibited tumor growth, improved lung function, and reduced myofibroblast markers (α-SMA, FAP). It upregulated Bax and Sirt3 while downregulating YME1L1, BCL-2, and EMT proteins (e.g., Vimentin), damaging to mitochondrial function. Mechanistically, Coptisine activated Sirt3 to deacetylate YME1L1, inducing mitochondrial fragmentation in CAFs. These findings highlight Coptisine's potential as a lung cancer therapy by targeting the Sirt3/YME1L1 pathway in CAFs.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102148"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LINC01123 drives autophagy-mediated promotion of ovarian tumor metastasis through the p65/ATG13 pathway","authors":"Xiao Yan ,&nbsp;Shuang Miao ,&nbsp;Bozhen Fan ,&nbsp;Zeyu Xu ,&nbsp;Yunzhi Zhao ,&nbsp;Chenyue Yuan ,&nbsp;Ziliang Wang ,&nbsp;Yongning Sun","doi":"10.1016/j.jrras.2025.102118","DOIUrl":"10.1016/j.jrras.2025.102118","url":null,"abstract":"<div><h3>Background</h3><div>Long non-coding RNAs (lncRNAs) are increasingly recognized as critical regualtors in cancer biology, including ovarian cancer (OC). Analysis of the OC cohort in the Cancer Genome Atlas (TCGA) revealed that LINC011123 is significantly upregulated in OC compared to normal ovarian tissue. Nonetheless, the functional consequence of this upregulation and the underlying mechanism of LINC01123 in OC remain unclear. We hypothesized that elevated LINC01123 exerts an oncogenic function.</div></div><div><h3>Methods</h3><div>RNA sequencing datasets from TCGA were analyzed to identify the RNAs with differential expression in OC tissues relative to standard ovarian tissue. The role of LINC01123 in regulating cell proliferation, migration, and autophagy was defined through functional experiments including wound healing, transwell, and western blotting <em>in vitro</em>, and a xenograft mouse model <em>in vivo</em>. LINC01123 regulation underwent investigation using RNA pulldown and mass spectrometry, RNA immunoprecipitation, luciferase reporter assays, and so on.</div></div><div><h3>Results</h3><div>LINC01123 is one of the most highly increased lncRNAs in OC specimens compared to non-cancerous ovarian tissue. Downregulation of LINC01123 functioned to suppress proliferation and cellular migration. RNA pulldown and gene set enrichment analysis suggested that the amount of LINC01123 positively correlated with genes involved in autophagy. LINC01123 promoted autophagy by promoting ATG13 expression. Further mechanistic studies showed that LINC01123 directly binds to p65 to activate ATG13 transcription, promoting autophagy and facilitating OC tumorigenesis.</div></div><div><h3>Conclusion</h3><div>Our results uncovered the oncogenic function and mechanism of LINC01123 in OC. LINC01123 associates with p65, augmenting autophagy, which in turn facilitates tumor metastasis within OC cells by increasing ATG13 expression. LINC01123 is a potential therapeutic target for OC patients.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102118"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naringenin attenuates inflammation and apoptosis in lipopolysaccharide-induced H9c2 cardiomyocytes","authors":"Fang Wang ,&nbsp;Rui Dai","doi":"10.1016/j.jrras.2025.102115","DOIUrl":"10.1016/j.jrras.2025.102115","url":null,"abstract":"<div><h3>Background</h3><div>Naringenin, a natural flavonoid, has various pharmacological effects. However, the function of naringenin in cardiac inflammation remains unclear. This study investigated whether naringenin alleviates cardiac inflammatory induced by lipopolysaccharide (LPS).</div></div><div><h3>Methods</h3><div>Naringenin's regulatory targets in inflammation and apoptosis were investigated using network pharmacology and molecular docking. LPS activated H9c2 cardiomyocytes, which were then treated with naringenin.</div></div><div><h3>Results</h3><div>Naringenin (20 or 40 μM) reduced the expression of cytokine induced by LPS (P &lt; 0.05). In LPS-induced cells treated with naringenin (20 μM), the nuclear translocation of p65 was inhibited, concomitantly with a significant reduction in IκBα degradation. TUNEL staining revealed that naringenin (20 μM) significantly reduced apoptosis triggered by LPS (P &lt; 0.05). Naringenin (20 μM) also significantly decreased the expression level of Bax and cleaved-caspase 3, and significantly elevated Bcl-2 expression.</div></div><div><h3>Conclusion</h3><div>Naringenin may be able to attenuate H9c2 cardiomyocyte inflammation and apoptosis induced by LPS.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102115"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated bioinformatic analysis and experimental validation identify IDH2 as a key mitochondrial energy metabolism-ferroptosis biomarker in ischemic stroke","authors":"Mingqin Zhang ,&nbsp;Jin Xu ,&nbsp;Dongyi Yang ,&nbsp;Jiabin Wang ,&nbsp;Sha Luo ,&nbsp;Yiping Wang","doi":"10.1016/j.jrras.2025.102140","DOIUrl":"10.1016/j.jrras.2025.102140","url":null,"abstract":"<div><h3>Background</h3><div>Ischemic stroke (IS) is implicated in disruptions of mitochondrial energy metabolism and ferroptosis. However, the underlying mechanisms remain elusive.</div></div><div><h3>Methods</h3><div>Three stroke-related transcriptome datasets (GSE22255, GSE58294, and GSE16561) were retrieved from the GEO database. A series of bioinformatic analyses were conducted, including differential expression analysis, functional enrichment, and protein–protein interaction (PPI) network construction. We further applied random forest modeling and single-cell sequencing to screen mitochondrial energy metabolism- and ferroptosis-related genes. The diagnostic value and immune correlations of these genes were further validated. We constructed an IS model in HT22 cells with OGD/R induction and employed IDH2 overexpression by transfection for subsequent functional validation.</div></div><div><h3>Results</h3><div>8 differentially expressed genes (DEGs) were identified (MGST1, ACSL1, PDK4, IDH2, ECH1, GPX4, BCAT2, PARK7). Functional enrichment analysis revealed their involvement in pathways like pyruvate metabolism and immune response regulation. In the random forest model, IDH2 showed a promising diagnostic value in the external validation set (AUC = 0.682). Single-cell analysis identified specific expression of IDH2 in glial cells and MGST1 in astrocytes, with both genes showing a notable correlation to macrophage infiltration. Notably, IDH2 expression was markedly reduced in IS cell models, and its overexpression significantly improved mitochondrial energy metabolism and inhibited ferroptosis.</div></div><div><h3>Conclusion</h3><div>This study elucidated the critical roles of mitochondrial energy metabolism–ferroptosis–related genes in IS and highlights IDH2 as a key candidate for disease diagnosis and potential therapeutic intervention. And its overexpression significantly improved mitochondrial energy metabolism and inhibited ferroptosis, suggesting a protective mechanistic role.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102140"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced indirect sealing of cerebrospinal fluid leaks in anterior cervical surgery using plate mechanical pressure","authors":"Dong Liu,&nbsp;Leisheng Wang,&nbsp;Xiaoguang Fan","doi":"10.1016/j.jrras.2026.102196","DOIUrl":"10.1016/j.jrras.2026.102196","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the effectiveness and safety of the “indirect sealing method” for managing cerebrospinal fluid leakage (CSFL) during anterior cervical spine surgery (ACSS), using magnetic resonance imaging (MRI) imaging.</div></div><div><h3>Methods</h3><div>A retrospective analysis included 30 patients with CSFL during ACSS for ossification of the posterior longitudinal ligament. Patients were divided into the Patch group (application of an artificial dura mater patch + hemostatic gelatin on the dura surface, n = 15) and the Patch + Plate group (artificial dura patch positioned between the vertebral body and the titanium plate, n = 15). Effectiveness was assessed via total CSFL drainage volume, drainage tube duration, and CSFL incidence on MRI at 3 days, 1 month, and 3 months postoperatively. Safety was evaluated based on sealing-related and surgery-related complications. Surgical efficacy was measured using modified Japanese orthopedic association score (mJOA), visual analog scale (VAS), and neck disability index (NDI) scores preoperatively and at 3 months, along with time to ambulation and total hospital stay.</div></div><div><h3>Results</h3><div>The Patch + Plate group had significantly lower total CSFL drainage volume (P = 0.004) and shorter drainage tube duration (P = 0.005). CSFL incidence was lower in the Patch + Plate group at 3 days (P = 0.003), 1 month (P = 0.015), and 3 months (P = 0.015). Low intracranial pressure headache (P = 0.002) was lower in the Patch + Plate group. At 3 months, the Patch + Plate group showed better mJOA (P = 0.038), VAS (P = 0.025), and NDI (P = 0.044) scores, as well as shorter time to ambulation (P = 0.041) and total hospital stay (P = 0.031).</div></div><div><h3>Conclusion</h3><div>Placing the patch between the titanium plate and the vertebral body to achieve a tight seal using the mechanical pressure of the titanium plate can improve sealing effectiveness, reduces CSFL-related complications, and enhances postoperative recovery in ACSS.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102196"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell toxicity test, biocompatibility study and clinical study of juguang®-18HF polysulfone membrane dialyzer","authors":"Chen Yun ,&nbsp;Xiaofan He ,&nbsp;Lifeng Yang ,&nbsp;Suhua Xu ,&nbsp;Yunyi Li ,&nbsp;Huiyi Zeng ,&nbsp;Xianggeng Chi ,&nbsp;Ao-ieong Chi-Wa ,&nbsp;Boxun Wang ,&nbsp;Zhuoheng Song ,&nbsp;Zhangzhang Xiao ,&nbsp;Wenyu Gong ,&nbsp;Jingxian Huang ,&nbsp;Donghao He ,&nbsp;Ting Xie ,&nbsp;Yong Dai ,&nbsp;Donge Tang ,&nbsp;Hongming Zhou ,&nbsp;Zigan Xu ,&nbsp;Lianghong Yin ,&nbsp;Aiyun Zha","doi":"10.1016/j.jrras.2025.102075","DOIUrl":"10.1016/j.jrras.2025.102075","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to investigate the cytotoxicity and biocompatibility of polysulfone hollow fiber dialyzers, while observing clinical efficacy, in order to provide a basis for preclinical and clinical research on polyethersulfone hollow fiber dialyzers for clinical application.</div></div><div><h3>Methods</h3><div>Twenty-four JUGUANG®-18HF dialyzers produced by polyether sulfone hollow fiber dialysis membrane produced by 3M Company were used for cytotoxicity test, in vitro mammalian cell chromosome aberration test, subchronic systemic toxicity test and clinical test. And observe clinical biocompatibility and efficacy through self-cross-validation non-inferiority verification.</div></div><div><h3>Results</h3><div>All animal and cell experiments showed that the cytotoxicity score of the treatment group was 0 points compared to the control group. According to the standard, the cytotoxicity and reaction degree were deemed as non-cytotoxic. Biochemical tests showed no statistical differences in any indicators. Clinical observations noted that blood samples were drawn from the arterial end of the vascular access before dialysis, 15 min after the start of dialysis, and at the end of dialysis. Routine blood tests, fragmented red blood cell analysis, and changes in CRP and liver function before and after dialysis were all found to be normal. The clearance and decline rates of BUN and Cr, as well as changes in electrolytes, showed no statistically significant difference compared to the control group in Parazacco spilurus subsp. spilurus.</div></div><div><h3>Conclusions</h3><div>The JUGUANG®-18HF hollow fiber dialyzer with polyether sulfone membrane produced by 3M company showed that it was in compliance with the regulations in cytotoxicity, chromosomal aberration of mammalian cells in vitro and subchronic systemic toxicity test. Clinical studies showed that it had good biocompatibilityand clinical efficacy.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102075"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of NORM and heavy metal risks from breakfast cereals consumed in the Kurdistan Region, Iraq","authors":"Halmat J. Hassan ,&nbsp;Farhad A. Hama Hassan","doi":"10.1016/j.jrras.2026.102186","DOIUrl":"10.1016/j.jrras.2026.102186","url":null,"abstract":"<div><div>This study analyses 22 commercially available cereal samples containing naturally occurring radioactive materials, imported and sold in major retailers within the Kurdistan Region, Iraq. Gamma-ray spectrometry and X-ray fluorescence were employed to assess radiological risk associated with cereal consumption. The activity concentrations of radionuclides ranged from 1.6 ± 0.35 to 68.5 ± 11.5 <span><math><mrow><msup><mrow><mspace></mspace><mtext>Bq</mtext><mspace></mspace><mtext>kg</mtext></mrow><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span> for ²³⁸U, 2.3 ± 0.24 to 96.4 ± 7.5 <span><math><mrow><msup><mrow><mspace></mspace><mtext>Bq</mtext><mspace></mspace><mtext>kg</mtext></mrow><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span> for ²³²Th, and 67.8 ± 5.2 to 1448 ± 92 <span><math><mrow><msup><mrow><mspace></mspace><mtext>Bq</mtext><mspace></mspace><mtext>kg</mtext></mrow><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span> for ⁴⁰K. Estimated annual effective doses were 59.07, 365.9, and 30.055 <span><math><mrow><mi>μ</mi><mtext>Sv</mtext><mspace></mspace><msup><mi>y</mi><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span> for ²³⁸U, ²³²Th, and ⁴⁰K, respectively, based on an assumed annual cereal intake of 5 kg for adults and 3.7 kg for children. Samples S4 and S5 exhibited the highest total AED, at 388.3 and 331.8 <span><math><mrow><mi>μ</mi><mtext>Sv</mtext><mspace></mspace><msup><mi>y</mi><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span>, respectively. The total effective dose of these samples surpasses the general public reference level of 290 <span><math><mrow><mi>μ</mi><mtext>Sv</mtext><mspace></mspace><msup><mi>y</mi><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span>, indicating unsuitability for consumption. The Pb concentrations in samples S8 and S17 markedly exceed the Codex international limit of 6 mg <span><math><mrow><msup><mtext>kg</mtext><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span>, reaching 25.6 and 31.7 mg <span><math><mrow><msup><mtext>kg</mtext><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span>, respectively. These findings suggest that food regulations should address potential radiation exposure from cereals to mitigate public health risks.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102186"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LRG1 protein is a novel prognostic indicator for patients with non-small cell lung cancer","authors":"Yingjia Mao ,&nbsp;Hao Yu ,&nbsp;Rong Yu ,&nbsp;Hongmei Niu ,&nbsp;Xin Deng ,&nbsp;Qing Qi ,&nbsp;Xiang Li ,&nbsp;Fuqian Zhao ,&nbsp;Daofu Shen ,&nbsp;Lei Wang","doi":"10.1016/j.jrras.2025.102154","DOIUrl":"10.1016/j.jrras.2025.102154","url":null,"abstract":"<div><h3>Background</h3><div>The lack of early diagnostic markers often leads to the late diagnosis of lung cancer. Although LRG1 was identified in the serum of metastatic patients, its functional role and diagnostic potential remain largely unexplored. We hypothesize that LRG1 promotes lung cancer progression via immune modulation and enhances metastatic potential.</div></div><div><h3>Methods</h3><div>We analyzed the relationship between LRG1 expression and survival outcomes using TCGA data. Immune cell relevance was assessed using the TIMER and TISCH databases. The functional effects of LRG1 on lung cancer cell proliferation and migration were investigated using CCK-8, EdU, scratch assays, and Western blot. Peripheral serum was collected from healthy controls (n = 15), non-metastatic groups (n = 13), and metastatic groups (n = 56). Serum LRG1 levels were detected by ELISA, and its diagnostic value was evaluated using ROC curve analysis.</div></div><div><h3>Results</h3><div>High LRG1 expression is associated with poor prognosis and is linked to macrophage and neutrophil infiltration. In vitro functional studies have shown that LRG1 promotes lung cancer cell proliferation and migration. Furthermore, serum LRG1 levels are significantly elevated in patients with metastatic lung cancer, and LRG1 demonstrates high diagnostic accuracy across all disease stages. In metastatic patients, LRG1 showed promising potential for early detection in LUAD patients (AUC = 0.74) and LUSC patients (AUC = 0.69), showing high levels in LUAD patients (AUC = 0.75) and LUSC patients (AUC = 0.73).</div></div><div><h3>Conclusion</h3><div>Our study has revealed the potential of LRG1 as a novel biomarker for early diagnosis and recurrence monitoring of lung cancer. It has diagnostic value in early-stage disease and prognostic value in late-stage disease. However, further investigation into its mechanistic role is warranted.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102154"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}