Pub Date : 2026-03-01Epub Date: 2026-01-28DOI: 10.1016/j.jrras.2026.102206
Ermei Peng , Shaonan Hu , Shuqin Liu
Objective
By integrating transcriptomic datasets and performing subsequent laboratory validation, this research sought to uncover molecular markers shared by periodontitis and colorectal cancer.
Methods
Transcriptomic sequencing was performed on periodontitis and colorectal cancer tissues versus normal controls (periodontitis: n = 12 diseased vs. n = 12 healthy controls; colorectal cancer: n = 15 tumor samples vs. n = 15 matched adjacent normal tissues), using the Illumina NovaSeq 6000 platform with 150-bp paired-end sequencing. Differentially expressed genes (DEGs) underwent GO and KEGG enrichment analysis. Weighted gene co-expression network analysis (WGCNA) identified disease-associated modules. Random forest modeling and Venn analysis determined overlapping biomarkers. Experimental validation used qRT-PCR, CCK-8 viability assays, and colony formation assays in relevant cell lines.
Results
Functional analysis revealed both diseases were enriched in immune-inflammatory pathways, including cytokine signaling, TNF and NF-κB pathways. WGCNA identified distinct gene co-expression modules. Random forest analysis identified PLAC8, CLCA4, SEMA6D, CHP2, and ADAMDEC1 as top predictive features. Cross-disease analysis revealed seven shared genes. Experimental assays demonstrated a significant increase in PLAC8 and ADAMDEC1 expression, along with a marked reduction in CLCA4 under disease conditions (P < 0.001). Functional studies demonstrated that modulating these genes had a significant impact on cell viability and colony formation (P < 0.001).
Conclusion
This study identifies shared immune-inflammatory mechanisms between periodontitis and colorectal cancer, with PLAC8, CLCA4, and ADAMDEC1 as common biomarkers, providing insights into disease linkage and potential therapeutic targets.
{"title":"Transcriptomic integration and functional validation reveal PLAC8, CLCA4, and ADAMDEC1 as key biomarkers linking periodontitis and colorectal cancer","authors":"Ermei Peng , Shaonan Hu , Shuqin Liu","doi":"10.1016/j.jrras.2026.102206","DOIUrl":"10.1016/j.jrras.2026.102206","url":null,"abstract":"<div><h3>Objective</h3><div>By integrating transcriptomic datasets and performing subsequent laboratory validation, this research sought to uncover molecular markers shared by periodontitis and colorectal cancer.</div></div><div><h3>Methods</h3><div>Transcriptomic sequencing was performed on periodontitis and colorectal cancer tissues versus normal controls (periodontitis: n = 12 diseased vs. n = 12 healthy controls; colorectal cancer: n = 15 tumor samples vs. n = 15 matched adjacent normal tissues), using the Illumina NovaSeq 6000 platform with 150-bp paired-end sequencing. Differentially expressed genes (DEGs) underwent GO and KEGG enrichment analysis. Weighted gene co-expression network analysis (WGCNA) identified disease-associated modules. Random forest modeling and Venn analysis determined overlapping biomarkers. Experimental validation used qRT-PCR, CCK-8 viability assays, and colony formation assays in relevant cell lines.</div></div><div><h3>Results</h3><div>Functional analysis revealed both diseases were enriched in immune-inflammatory pathways, including cytokine signaling, TNF and NF-κB pathways. WGCNA identified distinct gene co-expression modules. Random forest analysis identified PLAC8, CLCA4, SEMA6D, CHP2, and ADAMDEC1 as top predictive features. Cross-disease analysis revealed seven shared genes. Experimental assays demonstrated a significant increase in PLAC8 and ADAMDEC1 expression, along with a marked reduction in CLCA4 under disease conditions (P < 0.001). Functional studies demonstrated that modulating these genes had a significant impact on cell viability and colony formation (P < 0.001).</div></div><div><h3>Conclusion</h3><div>This study identifies shared immune-inflammatory mechanisms between periodontitis and colorectal cancer, with PLAC8, CLCA4, and ADAMDEC1 as common biomarkers, providing insights into disease linkage and potential therapeutic targets.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102206"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-28DOI: 10.1016/j.jrras.2026.102180
Ari Satmoko, Roziq Himawan, Djarot Sulistio Wisnubroto, Mohammad Dhandhang Purwadi, Ferly Hermana, Budi Santoso, Agus Cahyono, Jos Budi Sulistyo, Hasriyasti Saptowati, Puji Santosa, Totti Tjiptosumirat, Dede Sutarya, Sunarto Sunarto, Agus Sumaryanto, Bang Rozali, Kristedjo Kurnianto, Jaja Sukmana
A low-cost mechanical–control retrofit for the Merah Putih Gamma Irradiator (IGMP) is presented, aimed at shortening tote-transfer cycle time and improving simulated dose uniformity without altering the source or shielding. The intervention simplifies the pneumatic sequence from nine to six stages and slightly reassigns two tote positions to preserve path symmetry relative to the 60Co racks. Based on operational logs and prototype testing, the average cycle time decreased from ∼65.3 s to ∼43.2 s per cycle (≈33.7 %), reducing the minimum batch duration from ∼78 to ∼50 min and widening the operating window for low-dose services (e.g., phytosanitary treatment, sprout inhibition). To evaluate potential dose effects, a comparative MicroShield v7 calculation was performed across all 72 irradiation positions on two quasi-2D planes. The simulated range narrowed primarily by lifting the minimum from 91.98 mSv to 130.86 mSv, while the peak remained at 1050.34 mSv. Consequently, the Dose Uniformity Ratio (DUR) improved from 11.4 to 8.0, indicating better homogeneity. Position-level analysis shows tote #37 increasing from 91.98 mSv to 131.04 mSv after reassignment, whereas tote #55 remains essentially unchanged (∼145.69 mSv). Assuming total simulated dose is represented by sampled points, the 72-cycle total rises from 32,896.96 mSv to 32,935.02 mSv (≈+0.12 %). Limitations: the six-stage sequence has not yet been deployed in production; results are based on full-scale prototype testing and simulations using a free-field approximation (no bunker scatter). Therefore, validation by field dose mapping under production conditions is required. Overall, the retrofit offers a transferable sequencing framework for tote-based irradiators in resource-constrained settings.
{"title":"Optimizing tote transfer cycle time in a gamma irradiator via pneumatic system redesign: A case study of IGMP Indonesia","authors":"Ari Satmoko, Roziq Himawan, Djarot Sulistio Wisnubroto, Mohammad Dhandhang Purwadi, Ferly Hermana, Budi Santoso, Agus Cahyono, Jos Budi Sulistyo, Hasriyasti Saptowati, Puji Santosa, Totti Tjiptosumirat, Dede Sutarya, Sunarto Sunarto, Agus Sumaryanto, Bang Rozali, Kristedjo Kurnianto, Jaja Sukmana","doi":"10.1016/j.jrras.2026.102180","DOIUrl":"10.1016/j.jrras.2026.102180","url":null,"abstract":"<div><div>A low-cost mechanical–control retrofit for the Merah Putih Gamma Irradiator (IGMP) is presented, aimed at shortening tote-transfer cycle time and improving simulated dose uniformity without altering the source or shielding. The intervention simplifies the pneumatic sequence from nine to six stages and slightly reassigns two tote positions to preserve path symmetry relative to the <sup>60</sup>Co racks. Based on operational logs and prototype testing, the average cycle time decreased from ∼65.3 s to ∼43.2 s per cycle (≈33.7 %), reducing the minimum batch duration from ∼78 to ∼50 min and widening the operating window for low-dose services (e.g., phytosanitary treatment, sprout inhibition). To evaluate potential dose effects, a comparative MicroShield v7 calculation was performed across all 72 irradiation positions on two quasi-2D planes. The simulated range narrowed primarily by lifting the minimum from 91.98 mSv to 130.86 mSv, while the peak remained at 1050.34 mSv. Consequently, the Dose Uniformity Ratio (DUR) improved from 11.4 to 8.0, indicating better homogeneity. Position-level analysis shows tote #37 increasing from 91.98 mSv to 131.04 mSv after reassignment, whereas tote #55 remains essentially unchanged (∼145.69 mSv). Assuming total simulated dose is represented by sampled points, the 72-cycle total rises from 32,896.96 mSv to 32,935.02 mSv (≈+0.12 %). Limitations: the six-stage sequence has not yet been deployed in production; results are based on full-scale prototype testing and simulations using a free-field approximation (no bunker scatter). Therefore, validation by field dose mapping under production conditions is required. Overall, the retrofit offers a transferable sequencing framework for tote-based irradiators in resource-constrained settings.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102180"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-08DOI: 10.1016/j.jrras.2025.102120
Hongpeng Zhao, Zhihua Liang, Feng Li, Haihua Yu, Kai Li, Bo Liu
Background
Lymphangiogenesis plays a significant role in tumor metastasis, making it a critical target for cancer therapies. PRMT5, an oncogene involved in various cellular processes, and SIRT7, a desuccinylase, regulate this process in gastric cancer (GC) through complex signaling pathways. However, the specific role of PRMT5 in tumor-induced lymphangiogenesis remains largely unexplored. This study investigates the role of SIRT7 in modulating PRMT5 expression and its impact on lymphangiogenesis through the ERK1/2 signaling pathway in GC.
Methods
All functional assays were performed using human lymphatic endothelial cells (HLECs). HLECs were subjected to PRMT5 and SIRT7 knockdown or overexpression via lentiviral transfection. Cell proliferation was evaluated by CCK-8 assay, tube formation was assessed using Matrigel assays, and protein expression was detected by Western blotting. VEGF-C secretion was measured by ELISA, and Co-immunoprecipitation was performed to examine the interaction between SIRT7 and PRMT5. The ERK1/2 signaling pathway was analyzed to elucidate downstream mechanisms.
Results
PRMT5 knockdown inhibited lymphangiogenesis and reduced VEGF-C expression, while SIRT7 suppression increased PRMT5 levels, enhancing endothelial cell proliferation and tube formation. Western blotting showed that PRMT5 activates the ERK1/2 pathway, which is essential for VEGF-C regulation. Co-immunoprecipitation further confirmed a direct interaction between SIRT7 and PRMT5, supporting the regulatory link between these proteins.
Conclusions
We identify the SIRT7/PRMT5/ERK1/2/VEGF-C axis as a novel and key regulator of lymphangiogenesis in GC, with significant potential therapeutic implications.
{"title":"SIRT7-mediated desuccinylation of PRMT5 activates the ERK1/2-VEGF-C axis to promote lymphangiogenesis in gastric cancer","authors":"Hongpeng Zhao, Zhihua Liang, Feng Li, Haihua Yu, Kai Li, Bo Liu","doi":"10.1016/j.jrras.2025.102120","DOIUrl":"10.1016/j.jrras.2025.102120","url":null,"abstract":"<div><h3>Background</h3><div>Lymphangiogenesis plays a significant role in tumor metastasis, making it a critical target for cancer therapies. PRMT5, an oncogene involved in various cellular processes, and SIRT7, a desuccinylase, regulate this process in gastric cancer (GC) through complex signaling pathways. However, the specific role of PRMT5 in tumor-induced lymphangiogenesis remains largely unexplored. This study investigates the role of SIRT7 in modulating PRMT5 expression and its impact on lymphangiogenesis through the ERK1/2 signaling pathway in GC.</div></div><div><h3>Methods</h3><div>All functional assays were performed using human lymphatic endothelial cells (HLECs). HLECs were subjected to PRMT5 and SIRT7 knockdown or overexpression via lentiviral transfection. Cell proliferation was evaluated by CCK-8 assay, tube formation was assessed using Matrigel assays, and protein expression was detected by Western blotting. VEGF-C secretion was measured by ELISA, and Co-immunoprecipitation was performed to examine the interaction between SIRT7 and PRMT5. The ERK1/2 signaling pathway was analyzed to elucidate downstream mechanisms.</div></div><div><h3>Results</h3><div>PRMT5 knockdown inhibited lymphangiogenesis and reduced VEGF-C expression, while SIRT7 suppression increased PRMT5 levels, enhancing endothelial cell proliferation and tube formation. Western blotting showed that PRMT5 activates the ERK1/2 pathway, which is essential for VEGF-C regulation. Co-immunoprecipitation further confirmed a direct interaction between SIRT7 and PRMT5, supporting the regulatory link between these proteins.</div></div><div><h3>Conclusions</h3><div>We identify the SIRT7/PRMT5/ERK1/2/VEGF-C axis as a novel and key regulator of lymphangiogenesis in GC, with significant potential therapeutic implications.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102120"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-02-02DOI: 10.1016/j.jrras.2026.102204
Hani Negm , Meshal Alzaid , M.A.M. Uosif , Hayder Suhail Najm , Reda Elsaman , Atef El-Taher , Mohamed Kamal , El-Montser M. Seleem , Gaber Mahmoud Saadawy , Ahmed Ali Abdelrhman
Natural radionuclides in sediments and ecosystems, influenced by local geology, can pose significant environmental and human health risks. This study provides a comprehensive radiological assessment of the Abu-Tartur phosphate mine in Egypt, integrating multivariate statistical analysis to elucidate the relationships between radioactivity and radiological parameters. Twenty phosphate deposit samples, categorized as non-oxidized (black rock) and oxidized (yellow rock), were analyzed using gamma-ray spectrometry to determine the activity concentrations of 226Ra, 232Th, and 40K. The average activity concentrations were found to be 99.5 ± 4.92, 38.1 ± 1.93, and 28.5 ± 1.47 Bq kg−1 for black rocks, and 125 ± 6.18, 47 ± 2.3, and 26 ± 1.37 Bq kg−1 for yellow rocks, respectively. Notably, the 226Ra and 232Th activity concentrations in the phosphate samples are 2.5–3 and 1.3–1.6 times higher than the worldwide average, respectively. The mean absorbed dose rates in the black and yellow rock samples were 67.25 and 94.9 nGy h−1, respectively, both exceeding the global average of 57 nGy h−1. The calculated excess lifetime cancer risk (ELCR) for both oxidized and non-oxidized samples surpassed the permissible world norm of 0.290 × 10−3. Principal Component Analysis (PCA) revealed a strong positive correlation between 226Ra and 232Th with radiation hazard indices, while 40K showed a negative correlation. These findings indicate a significant cancer risk associated with the ambient geology of the Abu-Tartur mining region and underscore the need for stringent radiation protection measures.
沉积物和生态系统中的天然放射性核素受到当地地质的影响，可构成重大的环境和人类健康风险。本研究对埃及Abu-Tartur磷矿进行了全面的放射学评估，整合多元统计分析来阐明放射性与放射参数之间的关系。20个磷酸盐矿床样品，分类为非氧化（黑色岩石）和氧化（黄色岩石），使用伽马射线能谱法分析，以确定226Ra， 232Th和40K的活性浓度。黑色岩石的平均活性浓度分别为99.5±4.92、38.1±1.93和28.5±1.47 Bq kg - 1，黄色岩石的平均活性浓度分别为125±6.18、47±2.3和26±1.37 Bq kg - 1。值得注意的是，磷酸盐样品中的226Ra和232Th活性浓度分别是世界平均水平的2.5-3倍和1.3-1.6倍。黑色和黄色岩石样品的平均吸收剂量率分别为67.25和94.9 nGy h - 1，均超过全球平均水平57 nGy h - 1。计算出的氧化和非氧化样品的超额终身癌症风险（ELCR）都超过了允许的世界标准0.290 × 10−3。主成分分析表明，226Ra和232Th与辐射危害指数呈显著正相关，而40K呈显著负相关。这些发现表明，Abu-Tartur矿区的环境地质与重大的癌症风险有关，并强调需要采取严格的辐射防护措施。
{"title":"Integrating multivariate statistics and natural radioactivity for radiation hazard assessment in Abu-Tartur phosphate mine, Egypt","authors":"Hani Negm , Meshal Alzaid , M.A.M. Uosif , Hayder Suhail Najm , Reda Elsaman , Atef El-Taher , Mohamed Kamal , El-Montser M. Seleem , Gaber Mahmoud Saadawy , Ahmed Ali Abdelrhman","doi":"10.1016/j.jrras.2026.102204","DOIUrl":"10.1016/j.jrras.2026.102204","url":null,"abstract":"<div><div>Natural radionuclides in sediments and ecosystems, influenced by local geology, can pose significant environmental and human health risks. This study provides a comprehensive radiological assessment of the Abu-Tartur phosphate mine in Egypt, integrating multivariate statistical analysis to elucidate the relationships between radioactivity and radiological parameters. Twenty phosphate deposit samples, categorized as non-oxidized (black rock) and oxidized (yellow rock), were analyzed using gamma-ray spectrometry to determine the activity concentrations of <sup>226</sup>Ra, <sup>232</sup>Th, and <sup>40</sup>K. The average activity concentrations were found to be 99.5 ± 4.92, 38.1 ± 1.93, and 28.5 ± 1.47 Bq kg<sup>−1</sup> for black rocks, and 125 ± 6.18, 47 ± 2.3, and 26 ± 1.37 Bq kg<sup>−1</sup> for yellow rocks, respectively. Notably, the <sup>226</sup>Ra and <sup>232</sup>Th activity concentrations in the phosphate samples are 2.5–3 and 1.3–1.6 times higher than the worldwide average, respectively. The mean absorbed dose rates in the black and yellow rock samples were 67.25 and 94.9 nGy h<sup>−1</sup>, respectively, both exceeding the global average of 57 nGy h<sup>−1</sup>. The calculated excess lifetime cancer risk (ELCR) for both oxidized and non-oxidized samples surpassed the permissible world norm of 0.290 × 10<sup>−3</sup>. Principal Component Analysis (PCA) revealed a strong positive correlation between <sup>226</sup>Ra and <sup>232</sup>Th with radiation hazard indices, while <sup>40</sup>K showed a negative correlation. These findings indicate a significant cancer risk associated with the ambient geology of the Abu-Tartur mining region and underscore the need for stringent radiation protection measures.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102204"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147394336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-19DOI: 10.1016/j.jrras.2026.102170
Yajing Lin , Xiaowan Zeng , Xiaoyan Li
<div><h3>Objective</h3><div>The aim of this study was to investigate the feasibility of predicting the efficacy of immunotherapy in non-small cell lung cancer (NSCLC) patients using computed tomography (CT) radiomics, and to evaluate the impact of predictive nursing interventions on the quality of life (QOL) and complication rates in these patients.</div></div><div><h3>Methods</h3><div>A total of 68 NSCLC patients treated in hospital were included and randomly assigned into two groups: control group (routine care) and intervention group (predictive nursing intervention in addition to routine care), with 34 patients in each group. All patients underwent contrast-enhanced CT scanning, with the tumor region of interest (ROI) delineated. Intensity, morphological features (sphericity), and texture characteristics (gray-level co-occurrence matrix) were extracted. A predictive model for immunotherapy efficacy was established, and the performance of logistic regression (LR), support vector machine (SVM), K-nearest neighbor (KNN), and Boosting algorithms was compared in terms of accuracy, specificity, precision, recall, and F-score. Additionally, the time of drain removal, hospital stay, post-care QOL scores (including physical function, psychological function, social function, and material life), and complication rates were recorded for both groups.</div></div><div><h3>Results</h3><div>In the prediction model, the LR model performed better on multiple key indicators, with higher accuracy (0.787 vs. 0.771/0.752/0.754), specificity (0.525 vs. 0.352/0.256/0.236), precision (0.895 vs. 0.753/0.761/0.778), recall (0.889 vs. 0.762/0.858/0.793), and F1 score (0.892 vs. 0.757/0.807/0.785) than SVM, KNN, and AdaBoost algorithms. Regarding nursing interventions, the intervention group had significantly shorter drain removal time (52.39 ± 4.32 h) and hospital stay (11.82 ± 1.84 days) compared to the control group (67.93 ± 5.76 h and 17.92 ± 2.91 days, respectively), with statistically significant differences (<em>P</em> < 0.05). Regarding nursing interventions, no significant difference was observed in the baseline QOL scores between the two patient groups at enrollment (<em>P</em> > 0.05), indicating comparability. Post-care, the intervention group showed significantly higher scores in physical function, psychological function, social function, and material life quality compared to the control group (<em>P</em> < 0.05). The incidence of complications in the intervention group (2.94 %) was lower than that in the control group (17.65 %), but the difference did not reach statistical significance (<em>P</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>CT imaging omics technology has shown potential as an auxiliary tool for predicting the efficacy of immunotherapy in NSCLC patients. The predictive nursing model studied in parallel within the same cohort indicates that this prospective nursing approach can significantly improve patient outcomes. This int
{"title":"Impact of computed tomography radiomics-based predictive model for immunotherapy efficacy in non-small cell lung cancer on predictive nursing outcomes","authors":"Yajing Lin , Xiaowan Zeng , Xiaoyan Li","doi":"10.1016/j.jrras.2026.102170","DOIUrl":"10.1016/j.jrras.2026.102170","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to investigate the feasibility of predicting the efficacy of immunotherapy in non-small cell lung cancer (NSCLC) patients using computed tomography (CT) radiomics, and to evaluate the impact of predictive nursing interventions on the quality of life (QOL) and complication rates in these patients.</div></div><div><h3>Methods</h3><div>A total of 68 NSCLC patients treated in hospital were included and randomly assigned into two groups: control group (routine care) and intervention group (predictive nursing intervention in addition to routine care), with 34 patients in each group. All patients underwent contrast-enhanced CT scanning, with the tumor region of interest (ROI) delineated. Intensity, morphological features (sphericity), and texture characteristics (gray-level co-occurrence matrix) were extracted. A predictive model for immunotherapy efficacy was established, and the performance of logistic regression (LR), support vector machine (SVM), K-nearest neighbor (KNN), and Boosting algorithms was compared in terms of accuracy, specificity, precision, recall, and F-score. Additionally, the time of drain removal, hospital stay, post-care QOL scores (including physical function, psychological function, social function, and material life), and complication rates were recorded for both groups.</div></div><div><h3>Results</h3><div>In the prediction model, the LR model performed better on multiple key indicators, with higher accuracy (0.787 vs. 0.771/0.752/0.754), specificity (0.525 vs. 0.352/0.256/0.236), precision (0.895 vs. 0.753/0.761/0.778), recall (0.889 vs. 0.762/0.858/0.793), and F1 score (0.892 vs. 0.757/0.807/0.785) than SVM, KNN, and AdaBoost algorithms. Regarding nursing interventions, the intervention group had significantly shorter drain removal time (52.39 ± 4.32 h) and hospital stay (11.82 ± 1.84 days) compared to the control group (67.93 ± 5.76 h and 17.92 ± 2.91 days, respectively), with statistically significant differences (<em>P</em> < 0.05). Regarding nursing interventions, no significant difference was observed in the baseline QOL scores between the two patient groups at enrollment (<em>P</em> > 0.05), indicating comparability. Post-care, the intervention group showed significantly higher scores in physical function, psychological function, social function, and material life quality compared to the control group (<em>P</em> < 0.05). The incidence of complications in the intervention group (2.94 %) was lower than that in the control group (17.65 %), but the difference did not reach statistical significance (<em>P</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>CT imaging omics technology has shown potential as an auxiliary tool for predicting the efficacy of immunotherapy in NSCLC patients. The predictive nursing model studied in parallel within the same cohort indicates that this prospective nursing approach can significantly improve patient outcomes. This int","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102170"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-20DOI: 10.1016/j.jrras.2026.102173
Songbin Yang , Xu Cui , Maohua Pang , Dandan Lv , Jichun Wu , Ying Li , Juhua Zhang
Objective
This study aimed to develop and validate an improved U-Net model for optimizing knee MRI reconstruction and used these optimized images to perform semi-quantitative assessments of cartilage damage severity in patients with knee osteoarthritis (KOA), as well as to explore the association between cartilage damage and subchondral bone marrow edema.
Methods
The improved U-shaped network (U-net) was utilized for optimizing the MRI images, and the network reconstruction time, structural similarity index measure (SSIM), and peak signal-to-noise ratio (PSNR) were analyzed. 108 patients with KOA who underwent magnetic resonance examination were included as the research objects. After the patients were divided into normal, mild, and severe groups, their grades of semi-quantitative evaluation of cartilage damage were analyzed.
Results
The SSIM of the improved U-net was significantly higher than that of the original U-net, and the difference between the reconstructed images and the original images was highly reduced. MRI could show the types of cartilage damage in the knee joint. An MRI system with the improved U-net model improved the quality of MRI images of KOA patients. The improved U-net achieved a mean PSNR of 42.7 dB and SSIM of 0.94 at a 20 % sampling rate, representing a 15 % and 10 % improvement over the standard U-net, respectively. After the improvement, the reconstruction time of the U-net became shorter. There was a statistically significant difference in the probability of cartilage injury grades I–IV occurring among subchondral bone marrow edema grades 1–3 (Z = 5.098, P < 0.05).
Conclusion
The semi-quantitative MRI assessment facilitated by the improved U-net shows promise for accurately displaying and grading articular cartilage damage in KOA. Further validation against arthroscopic findings and in multi-center cohorts is warranted before clinical adoption can be considered. In conclusion, the improved U-net provided knee MRI reconstructions with superior quantitative quality and speed. Using these images, semi-quantitative assessment revealed a significant association between the severity of subchondral bone marrow edema and cartilage injury grade, demonstrating the method's potential for structured image evaluation in KOA.
{"title":"Magnetic resonance imaging semi-quantitative evaluation of cartilage damage in patients with knee osteoarthritis","authors":"Songbin Yang , Xu Cui , Maohua Pang , Dandan Lv , Jichun Wu , Ying Li , Juhua Zhang","doi":"10.1016/j.jrras.2026.102173","DOIUrl":"10.1016/j.jrras.2026.102173","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to develop and validate an improved U-Net model for optimizing knee MRI reconstruction and used these optimized images to perform semi-quantitative assessments of cartilage damage severity in patients with knee osteoarthritis (KOA), as well as to explore the association between cartilage damage and subchondral bone marrow edema.</div></div><div><h3>Methods</h3><div>The improved U-shaped network (U-net) was utilized for optimizing the MRI images, and the network reconstruction time, structural similarity index measure (SSIM), and peak signal-to-noise ratio (PSNR) were analyzed. 108 patients with KOA who underwent magnetic resonance examination were included as the research objects. After the patients were divided into normal, mild, and severe groups, their grades of semi-quantitative evaluation of cartilage damage were analyzed.</div></div><div><h3>Results</h3><div>The SSIM of the improved U-net was significantly higher than that of the original U-net, and the difference between the reconstructed images and the original images was highly reduced. MRI could show the types of cartilage damage in the knee joint. An MRI system with the improved U-net model improved the quality of MRI images of KOA patients. The improved U-net achieved a mean PSNR of 42.7 dB and SSIM of 0.94 at a 20 % sampling rate, representing a 15 % and 10 % improvement over the standard U-net, respectively. After the improvement, the reconstruction time of the U-net became shorter. There was a statistically significant difference in the probability of cartilage injury grades I–IV occurring among subchondral bone marrow edema grades 1–3 (<em>Z</em> = 5.098, <em>P</em> < 0.05).</div></div><div><h3>Conclusion</h3><div>The semi-quantitative MRI assessment facilitated by the improved U-net shows promise for accurately displaying and grading articular cartilage damage in KOA. Further validation against arthroscopic findings and in multi-center cohorts is warranted before clinical adoption can be considered. In conclusion, the improved U-net provided knee MRI reconstructions with superior quantitative quality and speed. Using these images, semi-quantitative assessment revealed a significant association between the severity of subchondral bone marrow edema and cartilage injury grade, demonstrating the method's potential for structured image evaluation in KOA.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102173"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-12-25DOI: 10.1016/j.jrras.2025.102139
Xin Lian, Jiafeng Ding, Ting Chen, Xiaofen Wu
Background
This study aimed to investigate the role of bufalin in inhibiting the osteogenic differentiation of human renal interstitial fibroblasts (hRIFs) and explore its potential mechanism through the OCT4/BMP2/Smads signaling axis.
Methods
Osteogenic differentiation of hRIFs was induced via osteogenic medium (OM), and this osteogenic differentiation was evaluated via alizarin red staining for calcium nodule formation, cobalt chloride staining for alkaline phosphatase activity, and Western blotting (WB) analysis for the expression of key osteogenic protein. Then, differentiated osteoblasts were treated with various concentrations of bufalin, and cell viability was assessed via the MTT assay to determine the optimal concentration. To investigate whether the inhibitory effect of bufalin on osteogenic differentiation involves the OCT4/BMP2/Smads signaling pathway, Western blot analysis, OCT4 overexpression, and BMP2-targeting short hairpin RNA (sh-BMP2) were used.
Results
OM successfully induced osteogenic differentiation in hRIFs and this differentiation was inhibited by bufalin. Mechanistically, bufalin suppressed OCT4 expression and consequently inhibited BMP2/Smads pathway activation. Notably, OCT4 upregulation reversed the inhibitory effects of bufalin on hRIF growth and osteoblast differentiation. Conversely, BMP2 downregulation counteracted the pro-osteogenic effects induced by OCT4 upregulation in bufalin-treated cells.
Conclusion
Bufalin inhibits the osteogenic differentiation in hRIFs, via a mechanism involving the downregulation the OCT4/BMP2/Smads pathway. These findings reveal that bufalin plays an important regulatory role in the osteogenic differentiation of hRIFs, which may provide a theoretical foundation for future research into the treatment of Randall's plaque formation.
{"title":"Bufalin inhibits the osteogenic differentiation of renal interstitial fibroblasts through the OCT4/BMP2/Smads signaling axis","authors":"Xin Lian, Jiafeng Ding, Ting Chen, Xiaofen Wu","doi":"10.1016/j.jrras.2025.102139","DOIUrl":"10.1016/j.jrras.2025.102139","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the role of bufalin in inhibiting the osteogenic differentiation of human renal interstitial fibroblasts (hRIFs) and explore its potential mechanism through the OCT4/BMP2/Smads signaling axis.</div></div><div><h3>Methods</h3><div>Osteogenic differentiation of hRIFs was induced via osteogenic medium (OM), and this osteogenic differentiation was evaluated via alizarin red staining for calcium nodule formation, cobalt chloride staining for alkaline phosphatase activity, and Western blotting (WB) analysis for the expression of key osteogenic protein. Then, differentiated osteoblasts were treated with various concentrations of bufalin, and cell viability was assessed via the MTT assay to determine the optimal concentration. To investigate whether the inhibitory effect of bufalin on osteogenic differentiation involves the OCT4/BMP2/Smads signaling pathway, Western blot analysis, OCT4 overexpression, and BMP2-targeting short hairpin RNA (sh-BMP2) were used.</div></div><div><h3>Results</h3><div>OM successfully induced osteogenic differentiation in hRIFs and this differentiation was inhibited by bufalin. Mechanistically, bufalin suppressed OCT4 expression and consequently inhibited BMP2/Smads pathway activation. Notably, OCT4 upregulation reversed the inhibitory effects of bufalin on hRIF growth and osteoblast differentiation. Conversely, BMP2 downregulation counteracted the pro-osteogenic effects induced by OCT4 upregulation in bufalin-treated cells.</div></div><div><h3>Conclusion</h3><div>Bufalin inhibits the osteogenic differentiation in hRIFs, via a mechanism involving the downregulation the OCT4/BMP2/Smads pathway. These findings reveal that bufalin plays an important regulatory role in the osteogenic differentiation of hRIFs, which may provide a theoretical foundation for future research into the treatment of Randall's plaque formation.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102139"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indonesia is committed to achieving net zero greenhouse gas emissions by 2060. To meet this objective, a diversified energy strategy is needed, which includes the deployment of nuclear power plants in addition to other renewable energy sources. It is planned that the first NPP in Indonesia will be introduced in 2032 or no later than 2034, with a target of approximately 31 GWe by 2060. To meet this demand, various reactor types will be considered based on geographical and demographic conditions, including Small Modular Reactors (SMRs). One potential site, Pantai Gosong in West Kalimantan, is currently under evaluation. An important aspect of site evaluation is the radiological safety assessment for accident conditions. The assessment includes the air concentration and ground deposition of several isotopes, individual effective doses, and early countermeasures. Site-specific meteorological data, were taken from the relevant national agencies. This study focuses on assessing radiation doses and formulating early countermeasure strategies, specifically for shelter management, in response to a hypothetical accident involving an SMR at the site, based on two potential release scenarios. Simulations were conducted using PC-Cosyma code. The sheltering pattern generated by the PC Cosyma is displayed using GIS and combined with settlement area, existing buildings suifigura for shelter, and the road network. Simulation results show that the calculated individual effective doses to the public remain well below reference levels. Nevertheless, a cautious approach to early countermeasures must be applied by implementing sheltering within a specific radius. This strategy aims to reduce the risk of radiation exposure while also preparing for potential subsequent actions, such as evacuation or the distribution of stable iodine (KI) tablets, if necessary. Proposed special protection zones within a 2 km radius can be established for immediate response measures. The existing public facilities are adequate to shelter the population within a 2 km radius. However, the presence of arterial roads within this area poses a potential risk of radiation exposure. Thus, alternative routes outside the 2 km radius should be suggested to enable effective traffic management in the event of an emergency.
{"title":"Sheltering management to protect the population: A case study of radiological impact assessment under a postulated accident condition in Indonesia's first NPP site","authors":"Yarianto Sugeng Budi Susilo , Muhammad Budi Setiawan , Jaja Sukmana , Anik Purwaningsih , Khusnul Khotimah , Djarot Sulistio Wisnubroto , Mohammad Dhandhang Purwadi , Anis Rohanda , Hery Adrial , Heni Susiati , Erlan Dewita , Totti Tjiptosumirat , Ferly Hermana , Wahyu Retno Prihatiningsih , Murdahayu Makmur , June Mellawati , Sunarko Sunarko , Suparman Suparman , Roziq Himawan , Dede Sutarya","doi":"10.1016/j.jrras.2025.102125","DOIUrl":"10.1016/j.jrras.2025.102125","url":null,"abstract":"<div><div>Indonesia is committed to achieving net zero greenhouse gas emissions by 2060. To meet this objective, a diversified energy strategy is needed, which includes the deployment of nuclear power plants in addition to other renewable energy sources. It is planned that the first NPP in Indonesia will be introduced in 2032 or no later than 2034, with a target of approximately 31 GWe by 2060. To meet this demand, various reactor types will be considered based on geographical and demographic conditions, including Small Modular Reactors (SMRs). One potential site, Pantai Gosong in West Kalimantan, is currently under evaluation. An important aspect of site evaluation is the radiological safety assessment for accident conditions. The assessment includes the air concentration and ground deposition of several isotopes, individual effective doses, and early countermeasures. Site-specific meteorological data, were taken from the relevant national agencies. This study focuses on assessing radiation doses and formulating early countermeasure strategies, specifically for shelter management, in response to a hypothetical accident involving an SMR at the site, based on two potential release scenarios. Simulations were conducted using PC-Cosyma code. The sheltering pattern generated by the PC Cosyma is displayed using GIS and combined with settlement area, existing buildings suifigura for shelter, and the road network. Simulation results show that the calculated individual effective doses to the public remain well below reference levels. Nevertheless, a cautious approach to early countermeasures must be applied by implementing sheltering within a specific radius. This strategy aims to reduce the risk of radiation exposure while also preparing for potential subsequent actions, such as evacuation or the distribution of stable iodine (KI) tablets, if necessary. Proposed special protection zones within a 2 km radius can be established for immediate response measures. The existing public facilities are adequate to shelter the population within a 2 km radius. However, the presence of arterial roads within this area poses a potential risk of radiation exposure. Thus, alternative routes outside the 2 km radius should be suggested to enable effective traffic management in the event of an emergency.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102125"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-21DOI: 10.1016/j.jrras.2026.102166
Zhenghuan Li , Fantu Kong , Manya Wu , Eryan Sun , Zhi Zhong , Chao Wang , Ru Wang , Yadi He , Pan Liu , Jie Dong , Huamei Yan , Gaokui He
Purpose
To compare setup errors between vacuum-bag with thermoplastic shell (VB) and abdominal compression with foam (AC) immobilization techniques in radiotherapy for hepatocellular carcinoma (HCC) with lymph node metastases (LNM), and evaluate their impacts on planning target volume (PTV) margins and dosimetry.
Methods
This retrospective cohort study of 34 HCC patients with LNM (VB group: n = 17; AC group: n = 17) was performed. Setup errors were verified by cone-beam CT (CBCT), and PTV margins were calculated using the van Herk formula (MPTV = 2.5Σ+0.7σ). Dosimetric parameters (conformity index, CI; homogeneity index, HI) and organ-at-risk (OAR) doses were compared.
Results
The VB group demonstrated significantly smaller calculated PTV margins in the superior-inferior (Y-axis) direction (0.32 cm vs. 0.57 cm, p = 0.001). Systematic errors (Σ) were lower for VB in the X and Y axes, while random errors (σ) were lower in the Z-axis. Dosimetrically, the VB group achieved significantly better dose conformity (CI: 0.24 ± 1.09 % vs. −0.76 ± 1.50 %, p = 0.04). No statistically significant differences were observed in other PTV parameters (Dmax, Dmean, TC, HI) or in the majority of OAR dose parameters, although a trend favoring VB was noted in several instances (e.g., Liver V30, p = 0.04).
Conclusion
For HCC patients with LNM undergoing IMRT, vacuum bag fixation significantly reduces PTV margins along the superior-inferior direction and improves dose conformity compared to abdominal compression, offering a potential for optimized treatment planning.
目的比较热塑性壳体真空袋（VB）和腹腔压缩泡沫（AC）固定技术在肝癌伴淋巴结转移（LNM）放疗中的设置误差，并评价其对规划靶体积（PTV）边界和剂量学的影响。方法对34例肝癌合并LNM患者（VB组17例，AC组17例）进行回顾性队列研究。采用锥束CT （CBCT）验证安装误差，采用van Herk公式计算PTV边界（MPTV = 2.5Σ+0.7σ）。比较剂量学参数（符合性指数CI；均匀性指数HI）和器官危险（OAR）剂量。结果VB组在上下（y轴）方向的PTV计算边界明显减小（0.32 cm vs. 0.57 cm, p = 0.001）。VB在X轴和Y轴上的系统误差（Σ）较低，而在z轴上的随机误差（Σ）较低。剂量学上，VB组获得了更好的剂量一致性（CI: 0.24±1.09%比- 0.76±1.50%,p = 0.04）。在其他PTV参数（Dmax, Dmean， TC， HI）或大多数OAR剂量参数中没有观察到统计学上的显著差异，尽管在一些情况下（例如，肝脏V30， p = 0.04）注意到偏向VB的趋势。结论对于肝细胞癌合并LNM行IMRT的患者，真空袋内固定与腹部压迫相比，可显著减少上下方向PTV边界，提高剂量一致性，为优化治疗方案提供了可能。
{"title":"Dosimetric impact of vacuum bag vs. abdominal compression fixation on PTV margins in IMRT for hepatocellular carcinoma with lymph node metastasis","authors":"Zhenghuan Li , Fantu Kong , Manya Wu , Eryan Sun , Zhi Zhong , Chao Wang , Ru Wang , Yadi He , Pan Liu , Jie Dong , Huamei Yan , Gaokui He","doi":"10.1016/j.jrras.2026.102166","DOIUrl":"10.1016/j.jrras.2026.102166","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare setup errors between vacuum-bag with thermoplastic shell (VB) and abdominal compression with foam (AC) immobilization techniques in radiotherapy for hepatocellular carcinoma (HCC) with lymph node metastases (LNM), and evaluate their impacts on planning target volume (PTV) margins and dosimetry.</div></div><div><h3>Methods</h3><div>This retrospective cohort study of 34 HCC patients with LNM (VB group: n = 17; AC group: n = 17) was performed. Setup errors were verified by cone-beam CT (CBCT), and PTV margins were calculated using the van Herk formula (MPTV = 2.5Σ+0.7σ). Dosimetric parameters (conformity index, CI; homogeneity index, HI) and organ-at-risk (OAR) doses were compared.</div></div><div><h3>Results</h3><div>The VB group demonstrated significantly smaller calculated PTV margins in the superior-inferior (Y-axis) direction (0.32 cm vs. 0.57 cm, p = 0.001). Systematic errors (Σ) were lower for VB in the X and Y axes, while random errors (σ) were lower in the Z-axis. Dosimetrically, the VB group achieved significantly better dose conformity (CI: 0.24 ± 1.09 % vs. −0.76 ± 1.50 %, p = 0.04). No statistically significant differences were observed in other PTV parameters (Dmax, Dmean, TC, HI) or in the majority of OAR dose parameters, although a trend favoring VB was noted in several instances (e.g., Liver V30, p = 0.04).</div></div><div><h3>Conclusion</h3><div>For HCC patients with LNM undergoing IMRT, vacuum bag fixation significantly reduces PTV margins along the superior-inferior direction and improves dose conformity compared to abdominal compression, offering a potential for optimized treatment planning.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102166"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-12-05DOI: 10.1016/j.jrras.2025.102088
Yen Liang Tung , Gaber Sallam Salem Abdalla , M.M. Abd El-Raouf , M.A. El-Qurashi
We present a novel approach that utilizes a familiar trigonometric function with the aim of enhancing the descriptions of real-world events. The presented method mainly relies on the sine function and is henceforth referred to as the modified sine- (MS-) approach. The MS- method updates the data analysis tools by providing a more precise representation of practical data sets. In our case study, we utilize the MS- method on the Weibull distribution leading to a new model termed the modified sine-Weibull (MS-Weibull) distribution. We investigate different mathematical characteristics of the MS-Weibull distribution, with particular emphasis on its quantile function, which is crucial for generating random variates and defining quartiles as well as percentiles We also carry out the mathematical derivations of point estimators for the MS-Weibull distribution. The derived estimators are further evaluated through simulation studies under various parameter values. To validate the MS-Weibull distribution, we analyze two data sets, taken from the finance and radiation fields. Our investigations using numerical and visual methods show that the MS-Weibull distribution repeatedly offers the best results based on specific criteria for assessing the goodness of fit of the model to the data.
{"title":"A modified sine Weibull distribution with applications to finance and radiation sectors","authors":"Yen Liang Tung , Gaber Sallam Salem Abdalla , M.M. Abd El-Raouf , M.A. El-Qurashi","doi":"10.1016/j.jrras.2025.102088","DOIUrl":"10.1016/j.jrras.2025.102088","url":null,"abstract":"<div><div>We present a novel approach that utilizes a familiar trigonometric function with the aim of enhancing the descriptions of real-world events. The presented method mainly relies on the sine function and is henceforth referred to as the modified sine-<span><math><mi>G</mi></math></span> (MS-<span><math><mi>G</mi></math></span>) approach. The MS-<span><math><mi>G</mi></math></span> method updates the data analysis tools by providing a more precise representation of practical data sets. In our case study, we utilize the MS-<span><math><mi>G</mi></math></span> method on the Weibull distribution leading to a new model termed the modified sine-Weibull (MS-Weibull) distribution. We investigate different mathematical characteristics of the MS-Weibull distribution, with particular emphasis on its quantile function, which is crucial for generating random variates and defining quartiles as well as percentiles We also carry out the mathematical derivations of point estimators for the MS-Weibull distribution. The derived estimators are further evaluated through simulation studies under various parameter values. To validate the MS-Weibull distribution, we analyze two data sets, taken from the finance and radiation fields. Our investigations using numerical and visual methods show that the MS-Weibull distribution repeatedly offers the best results based on specific criteria for assessing the goodness of fit of the model to the data.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102088"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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