Journal of Radiation Research and Applied Sciences最新文献_第3页

Comparative analysis of operative time, blood loss, and X-ray parameters: Two-dimensional navigation guided percutaneous endoscopic transforaminal discectomy vs. conventional microscopic surgery for lumbar disc herniation 手术时间、失血量和X光参数的比较分析：二维导航引导下经皮内窥镜经椎间孔椎间盘切除术与传统显微镜手术治疗腰椎间盘突出症的比较

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences

Pub Date : 2024-10-14 DOI: 10.1016/j.jrras.2024.101142

Weidong Guo , Guifeng Xia , Xin Dong , Xiaoping Zhang , Weiliang Zhang , Bo Liao

Purpose

This retrospective comparative study aims to evaluate the clinical efficacy of two-dimensional (2D) navigation-guided percutaneous endoscopic transforaminal discectomy in comparison to conventional microscopic surgery for the treatment of lumbar disc herniation (LDH), based on operative time, blood loss, and X-ray examination parameters.

Methods

Clinical data of patients who underwent either 2D navigation-assisted endoscopic (2D-NAE) discectomy or conventional microscopic surgery for LDH were retrospectively reviewed. Baseline characteristics, perioperative data, clinical outcomes (including visual analog scale [VAS] scores, Oswestry Disability Index [ODI] scores, and Modified MacNab criteria), and complications were compared between the two groups.

Results

A total of 95 patients were included, with 80 having complete follow-up data. The 2D navigation group comprised 47 patients, while the conventional microscopic surgery group had 33 patients. Both groups showed significant improvement in VAS and ODI scores at each follow-up time point (P < 0.05). The perioperative analysis favored the 2D navigation-assisted group, with a significantly shorter operative time (42.77 ± 7.56 vs. 59.33 ± 3.30 min; p < 0.01) and lower blood loss (10.34 ± 2.24 vs. 11.55 ± 2.20 ml; p = 0.02). The number of X-ray examinations required was similar between the two groups (2.34 ± 0.48 vs. 2.39 ± 0.56; p = 0.65), and post-operative hospitalization durations were comparable (p = 0.5). Clinical efficacy, as reflected by VAS scores for legs and ODI scores, showed no significant differences between the groups. Additionally, the Modified MacNab criteria indicated similar rates of excellent and good outcomes.

Conclusion

Both 2D-NAE discectomy and conventional microscopic surgery demonstrated comparable therapeutic outcomes for LDH, with favorable clinical efficacy and safety profiles. However, 2D-NAE surgery may offer additional benefits, including shorter operative times, reduced blood loss, and fewer X-ray examinations.

方法回顾性研究了接受二维导航辅助内窥镜（2D-NAE）椎间盘切除术或传统显微手术治疗腰椎间盘突出症（LDH）的患者的临床数据。比较了两组患者的基线特征、围手术期数据、临床结果（包括视觉模拟量表[VAS]评分、Oswestry残疾指数[ODI]评分和改良MacNab标准）和并发症。二维导航组有 47 名患者，而传统显微手术组有 33 名患者。两组患者在每个随访时间点的 VAS 和 ODI 评分均有明显改善（P < 0.05）。围手术期分析显示，二维导航辅助组的手术时间明显更短（42.77 ± 7.56 分钟 vs. 59.33 ± 3.30 分钟；P = 0.01），失血量更少（10.34 ± 2.24 毫升 vs. 11.55 ± 2.20 毫升；P = 0.02）。两组所需的 X 光检查次数相似（2.34 ± 0.48 vs. 2.39 ± 0.56；p = 0.65），术后住院时间相当（p = 0.5）。腿部 VAS 评分和 ODI 评分反映的临床疗效在两组之间无显著差异。结论2D-NAE椎间盘切除术和传统显微镜手术对LDH的治疗效果相当，临床疗效和安全性良好。不过，2D-NAE 手术可能会带来更多益处，包括缩短手术时间、减少失血和减少 X 光检查。

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引用次数: 0

Effect of gut microbiota intervention on inflammatory responses and cellular immune function in hepatocellular carcinoma patients undergoing radiotherapy 肠道微生物群干预对接受放疗的肝细胞癌患者炎症反应和细胞免疫功能的影响

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences

Pub Date : 2024-10-14 DOI: 10.1016/j.jrras.2024.101131

Liying Liu , Yanna Fan , Hongying Pi

Objective

To analyze the changes in nutritional status, inflammatory response and cellular immune status of Hepatocellular Carcinoma (HCC) patients who received radiotherapy under GMB intervention and to clarify the effect of GMB intervention on HCC.

Methods

Ninety-two patients with HCC receiving radiotherapy were randomized into study and observation groups, 46 in each group. The control group used conventional radiotherapy, and the study group used the gut microbiota intervention. The gut microbiota before and after radiotherapy, and the liver function, clinical efficacy, inflammatory response, cellular immunity, and nutritional status before and after treatment were compared.

Results

Compared with the control group, the number of lactobacillus and Bifidobacterium increased significantly, the clinical efficacy was significantly enhanced, the liver function, cellular immunity and nutritional status were significantly improved, and the inflammatory response was significantly reduced, with statistically significant differences (P < 0.05).

Conclusion

gut microbiota intervention can improve the effect of radiotherapy and improve liver function in patients, and the mechanism is related to regulating cellular immune function of patients and inhibiting inflammatory response in patients.

方法将92例接受放疗的肝细胞癌（HCC）患者随机分为研究组和观察组，每组46例。对照组采用常规放疗，研究组采用肠道微生物群干预。结果与对照组相比，研究组乳酸杆菌和双歧杆菌数量明显增加，临床疗效明显提高，肝功能、细胞免疫和营养状况明显改善，炎症反应明显减轻，差异有统计学意义（P < 0.05）。结论肠道微生物群干预可提高放疗效果，改善患者肝功能，其机制与调节患者细胞免疫功能、抑制患者炎症反应有关。

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引用次数: 0

Comparing the efficacy of linovera spray plus hydrocortisone cream for breast cancer patients undergoing conformal radiotherapy 比较 linovera 喷雾剂和氢化可的松乳膏对接受适形放射治疗的乳腺癌患者的疗效

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences

Pub Date : 2024-10-14 DOI: 10.1016/j.jrras.2024.101137

Nadia Najafi Zade , Atefeh Sahebkari , Mohammadreza Elhaie , Negah Tavakolifard , Mahnaz Roayaei

Background

Breast cancer is one of the most prevalent malignancies globally, with a significant proportion of patients undergoing radiotherapy, a crucial treatment modality that substantially reduces recurrence rates. However, radiotherapy is often complicated by dermatological adverse effects ranging from mild erythema to severe dermal burns. Despite various interventions aimed at mitigating skin toxicities, the efficacy of hyperoxygenated fatty acids (HOFA) in this context remains underexplored.

Objective

To evaluate the effectiveness of topical HOFA (Linovera spray) in preventing radiotherapy-induced skin reactions in breast cancer patients undergoing conformal radiotherapy.

Methods

This prospective, randomized, controlled trial enrolled post-partial mastectomy breast cancer patients indicated for conformal radiotherapy targeting lymph node levels and the supraclavicular region, with dosages of 45–50 Gy and a 60 Gy tumor bed boost. Patients with active skin diseases or sensitivity to the study spray were excluded. The intervention group applied hydrocortisone ointment and Linovera spray twice daily to the treatment site, while the control group used only hydrocortisone ointment. Skin reactions were graded using the validated Global Skin Reaction Classification and assessed during radiotherapy weeks 3 and 5.

Results

All 60 randomized patients (intervention n = 24, control n = 28) developed radiation dermatitis. By week 5, the intervention group showed a statistically significant reduction in dermatitis severity versus controls (p = 0.04). Dermatitis grades also significantly worsened within both groups from week 3–5 (all p < 0.001).

Conclusion

While HOFA-based moisturizers did not statistically impact overall incidence or severity, marginal benefits were observed with prolonged Linovera spray plus hydrocortisone use versus hydrocortisone alone by week 5. Further research is warranted to explore HOFA's potential skin-protective effects.

背景乳腺癌是全球发病率最高的恶性肿瘤之一，相当一部分患者接受放射治疗，这是一种重要的治疗方式，可大大降低复发率。然而，放疗往往会因皮肤不良反应而变得复杂，从轻度红斑到严重的皮肤灼伤，不一而足。目的评估局部使用 HOFA（Linovera 喷雾剂）预防接受适形放疗的乳腺癌患者放疗引起的皮肤反应的效果。方法这项前瞻性随机对照试验招募了部分乳房切除术后的乳腺癌患者，这些患者需要接受以淋巴结水平和锁骨上区域为靶点的适形放疗，剂量为 45-50 Gy，肿瘤床增强剂量为 60 Gy。患有活动性皮肤病或对研究喷雾剂敏感的患者被排除在外。干预组在治疗部位涂抹氢化可的松软膏和 Linovera 喷雾剂，每天两次；对照组仅使用氢化可的松软膏。结果所有 60 名随机患者（干预组 24 人，对照组 28 人）都出现了放射性皮炎。到第 5 周时，干预组患者的皮炎严重程度较对照组明显降低（p = 0.04）。结论虽然基于 HOFA 的保湿剂并未对总体发病率或严重程度产生统计学影响，但到第 5 周时，长期使用 Linovera 喷雾剂加氢化可的松与单独使用氢化可的松相比，观察到微弱的益处。有必要开展进一步研究，探索 HOFA 的潜在皮肤保护作用。

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引用次数: 0

Analysis of heat generation and viscous dissipation with thermal radiation on unsteady hybrid nanofluid flow over a sphere with double-stratification: Case of modified Buongiorno's model 双层结构球体上非稳定混合纳米流体流动的热量产生和粘性耗散与热辐射分析：修正的布昂奥诺模型案例

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences

Pub Date : 2024-10-14 DOI: 10.1016/j.jrras.2024.101146

Zafar Mahmood , Khadija Rafique , Mushtaq Ahmad Ansari , Adnan , Umar Khan , Abhinav Kumar , Hamiden Abd El-Wahed Khalifa , Haifa Alqahtani

Purpose

This work uses entropy generation analysis to numerically analyze magnetohydrodynamics (MHD) unsteady flow, heat and mass transfer. The study considers changing viscosity, thermal radiation, viscous dissipation, mass suction, heat generation, and stratification processes in a hybrid nanofluid around a spinning sphere. A two-phase nanofluid flow model (Buongiorno model) is used to tackle the current challenge. Both the free stream velocity and the sphere's angular velocity changed over time.

Design/methodology/approach

The case study's complicated partial differential equations are transformed into simpler ordinary differential equations utilizing similarity transformation. Implementing the fourth-order Runge-Kutta Fehlberg method with a shooting scheme in MATHEMATICA has allowed us to get numerical solutions for ordinary differential structures.

Findings

The many aspects of these regulated physical characteristics have been elucidated and thoroughly examined via the use of charts and tables. For increasing values of unsteadiness parameter, the velocity profiles in the x-direction grow while they decrease in the z-direction. On the other hand, the temperature profile exhibits a dual pattern, and the concentration profile decreases. As the chemical reaction parameter climbs from 0.25 to 1.0, the Sherwood number for the nanofluid rises by 6721.39% and for the hybrid nanofluid, 3818.9%. When Nr increases from 0.2 to 0.8, nanofluid Nusselt number climbs 22.5% and hybrid nanofluid's Nusselt number rises 21.9%. The Brinkmann number and nanoparticle volume percentage are strongly associated with entropy production. Entropy generation is dual for the temperature difference, magnetic, radiation, and changeable viscosity parameters. The findings are also compared to those from the existing literature and are in excellent agreement with them.

目的本研究利用熵生成分析对磁流体力学（MHD）非稳态流动、传热和传质进行数值分析。研究考虑了围绕旋转球体的混合纳米流体中的粘度变化、热辐射、粘性耗散、质量吸力、热量产生和分层过程。研究采用了两相纳米流体流动模型（Buongiorno 模型）来应对当前的挑战。自由流速度和球体角速度均随时间变化。设计/方法/途径利用相似性变换将案例研究中复杂的偏微分方程转换为较简单的常微分方程。通过在 MATHEMATICA 中使用四阶 Runge-Kutta Fehlberg 方法和射击方案，我们得到了常微分结构的数值解。随着不稳定性参数值的增大，X 方向的速度曲线会增大，而 Z 方向的速度曲线会减小。另一方面，温度曲线呈现出双重模式，浓度曲线则有所下降。当化学反应参数从 0.25 上升到 1.0 时，纳米流体的舍伍德数上升了 6721.39%，混合纳米流体的舍伍德数上升了 3818.9%。当 Nr 从 0.2 增加到 0.8 时，纳米流体的努塞尔特数上升了 22.5%，混合纳米流体的努塞尔特数上升了 21.9%。布林克曼数和纳米粒子体积百分比与熵的产生密切相关。熵的产生与温差、磁性、辐射和可变粘度参数有关。研究结果还与现有文献进行了比较，结果非常吻合。

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引用次数: 0

Optical transmission, dielectric constants, and gamma shielding performance of Se95-xIn5Prx metallic alloys: Radiation protection applications Se95-xIn5Prx 金属合金的光学透射率、介电常数和伽马屏蔽性能：辐射防护应用

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences

Pub Date : 2024-10-14 DOI: 10.1016/j.jrras.2024.101147

Z.A. Alrowaili , Jamila S. Alzahrani , Canel Eke , I.O. Olarinoye , Sultan Alomairy , M.S. Al-Buriahi

Due to the high density of metals, metallic materials such as alloys have the potential to have high gamma-radiation-absorbing abilities. This would make them relevant in a radiation environment as either a shielding material or a radiation sensor. These would, however, depend on their gamma radiation responses. Research aimed at evaluating the gamma response parameters of different glassy alloys that have technical applications is scarce compared to the traditional characterization with respect to optical features, structural evolution, and mechanical strength. In this paper, the optical and radiation shielding abilities of Se95-xIn5Prx (x = 2, 4, and 6) glassy alloys were investigated using standard theoretical techniques. The mass attenuation coefficient (MAC) of the materials was computed using the XCOM software. Reflection loss values are 0.20218, 0.22634, and 0.22908 for SIPr1, SIPr2, and SIPr3, respectively, while the optical transmittance values are 0.66365, 0.63087, and 0.62723 in the same order. The metallization criterion declined when Pr increased in the alloy. The values of MAC ranged from 0.0317 cm²/g to 98.2099 cm²/g for SIPr1, 0.0319 cm²/g to 97.3798 cm²/g for SIPr2 and 0.0322 cm²/g to 96.5372 cm²/g for SIPr3. The Higher attenuation and absorption coefficients were found for Pr-rich alloys. Pr therefore increase the ability of the SIPr-alloy to attenuate and absorb photon energy. The optical parameters of the investigated alloys could be used to identify their optical applications. SIPr3 had comparatively higher shielding ability compared to some known shields and could thus be used for radiation control and protection purposes.

由于金属的高密度，合金等金属材料有可能具有很强的伽马辐射吸收能力。这使得它们在辐射环境中可以用作屏蔽材料或辐射传感器。不过，这取决于它们对伽马辐射的反应。与光学特征、结构演变和机械强度方面的传统表征相比，旨在评估具有技术应用价值的不同玻璃合金的伽马响应参数的研究还很少。本文采用标准理论技术研究了 Se95-xIn5Prx（x = 2、4 和 6）玻璃合金的光学和辐射屏蔽能力。使用 XCOM 软件计算了材料的质量衰减系数（MAC）。SIPr1、SIPr2 和 SIPr3 的反射损耗值分别为 0.20218、0.22634 和 0.22908，而透光率值依次为 0.66365、0.63087 和 0.62723。当合金中的 Pr 增加时，金属化标准下降。SIPr1 的 MAC 值为 0.0317 cm2/g 至 98.2099 cm2/g，SIPr2 为 0.0319 cm2/g 至 97.3798 cm2/g，SIPr3 为 0.0322 cm2/g 至 96.5372 cm2/g。富含镨的合金具有更高的衰减系数和吸收系数。因此，镨能提高 SIPr 合金衰减和吸收光子能量的能力。所研究合金的光学参数可用于确定其光学应用。与一些已知的屏蔽材料相比，SIPr3 具有更高的屏蔽能力，因此可用于辐射控制和防护目的。

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引用次数: 0

Thermodynamical analysis of bioconvective chemically reactive and magnetized thermal-radiative bidirectional Casson nanofluid flow with heat-sink-source aspects 生物对流化学反应和磁化热辐射双向卡松纳米流体流动的热力学分析

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences

Pub Date : 2024-10-14 DOI: 10.1016/j.jrras.2024.101138

Waqar Azeem Khan , Zubair Hussain , Mehboob Ali , Wakeel Ahmad , Shahah Almutairi

The determination of the present investigation is to interpret the constitution of MHD steady three-dimensional Casson nanofluid flow containing gyrotactic microorganism over a stretching sheet. Besides, the possessions of thermophoresis, thermal radiation and Brownian motion are considered in this investigation. We convert the subsequent non-linear PDE's are into ODE's by using suitable similarity variables. We numerically evaluate the obtained non-linear ordinary differential equations by using Bvp4c technique in mathematical solver MATLAB. The Casson fluid parameter related directly with the growing enactment of the temperature portrait. It can be detected that the concentration profile amplifies for the rising estimations of Porosity and magnetic parameter. The opposite behavior is observed in the microorganism field with growing estimates of the bioconvection Lewis number.

本研究的目的是解释在拉伸片上含有陀螺微生物的 MHD 稳定三维卡松纳米流体流动的构成。此外，本研究还考虑了热泳、热辐射和布朗运动。我们利用适当的相似变量将随后的非线性 PDE 转换为 ODE。我们利用数学求解器 MATLAB 中的 Bvp4c 技术对所得到的非线性常微分方程进行数值评估。卡松流体参数与温度肖像的增长直接相关。可以发现，随着孔隙度和磁性参数的升高，浓度曲线也随之升高。而在微生物领域，随着生物对流路易斯数的增加，则出现了相反的现象。

引用次数: 0

A short-term stochastic production simulation method for new energy power systems considering operation timing characteristics 考虑运行时序特征的新能源电力系统短期随机生产模拟方法

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences

Pub Date : 2024-10-12 DOI: 10.1016/j.jrras.2024.101132

Hongwei Chen, Xiaoyu Ding, Binbin Zhong, Xiaobo Zhou, Mingwei Peng, Kanghong Ning

Short-term stochastic production simulation is an important basis for the planning and evaluation of new energy power systems. To ensure that the simulation results meet the actual operating conditions, a short-term stochastic production simulation method for new energy power systems is proposed, which considers the operation timing characteristics. The method constructs a new energy operation model, analyzes its operation timing characteristics, and realizes the short-term stochastic production simulation of the new energy power system by considering the characteristics, the operation constraints of the new energy units and the power system operation constraints, and evaluates the reliability of the simulation results. The test results show that when the output fluctuation increased from 2% to 20%, the dynamic cost of a single new energy access increased from 34,400 yuan to 106,500 yuan, while the integration cost of integrating two new energy sources soared from 105,500 yuan to 339,100 yuan, and the cost increase was more obvious. Under the condition of high output power (such as 3500 MW), the total load loss probability of Fig. 1 is only 1.88MWh × a⁻¹, which is significantly lower than Fig. 2 (5.97MWh × a⁻¹), and the expected probability of battery power shortage and optical storage output deviation of Fig. 1 is also lower, indicating high system stability and control accuracy. The method presented in this paper has excellent performance in reducing the total system cost, and also shows the lowest value in terms of optical wind abandonment rate and optical wind abandonment rate. The optical wind abandonment rate is only 2.1% and the optical wind abandonment rate is 1.4%, and the system stability index reaches 0.92, both of which are obviously superior to the comparison method, showing strong system stability. The short-term stochastic production simulation of the new energy power system considering the operation timing characteristics is reasonable and can provide a reliable basis for the simulation, analyze the reliability of the power system planning scheme, and ensure the future planning and operation of the power system.

短期随机生产模拟是新能源电力系统规划和评估的重要依据。为确保仿真结果符合实际运行条件，提出了一种考虑运行时序特性的新能源电力系统短期随机生产仿真方法。该方法构建了新能源运行模型，分析了其运行时序特性，综合考虑了新能源机组特性、运行约束条件和电力系统运行约束条件，实现了新能源电力系统的短期随机生产仿真，并对仿真结果的可靠性进行了评估。试验结果表明，当出力波动从2%增加到20%时，单个新能源接入的动态成本从3.44万元增加到10.65万元，而集成两个新能源的集成成本从10.55万元飙升到33.91万元，成本增加更为明显。在高输出功率（如 3500 MW）条件下，图 1 的总负荷损失概率仅为 1.88MWh ×a-1，明显低于图 2（5.97MWh ×a-1），图 1 的电池缺电和光储输出偏差的预期概率也较低，说明系统稳定性和控制精度较高。本文提出的方法在降低系统总成本方面表现优异，在光弃风率和光弃风率方面也表现出最低值。光弃风率仅为 2.1%，光弃风率为 1.4%，系统稳定指数达到 0.92，均明显优于对比方法，显示出较强的系统稳定性。考虑运行时序特性的新能源电力系统短期随机生产仿真是合理的，可以为仿真提供可靠依据，分析电力系统规划方案的可靠性，保证未来电力系统的规划和运行。

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引用次数: 0

Heat and mass evaluation for free convective flow due to porous surface with thermal radiation and Dufour effects 具有热辐射和杜富尔效应的多孔表面自由对流的热量和质量评估

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences

Pub Date : 2024-10-10 DOI: 10.1016/j.jrras.2024.101134

Obulesu Mopuri , Charankumar Ganteda , Kashif Saleem , Mohammed El-Meligy , Jaya Lakshmi Pothala , Aruna Ganjikunta , Sami Ullah Khan , M. Ijaz Khn

The main attention of this investigation is to address the heat and mass transfer analysis driven by oscillatory inclined surface with influenced of Dufour effects. The mixed convection applications and saturated porous space is considered for current flow problem. The heat transfer prediction is associated to contribution of radiated effects and heat generation impact. The perturbation technique is used to compile the analytical computations. The solution accuracy is ensured with convincing pattern. Insight analysis with incorporating the effects of parameters has been focused. The predicted observations reveal that the velocity enhances for thermal and mass Grashof coefficients and inclined angle. The heat transfer increases with peak values of Dufour number. The results show applications in heat transfer systems, manufacturing processes, chemical reactions, nuclear systems, cooling processes etc.

本研究的主要关注点是解决受杜富尔效应影响的摆动倾斜表面驱动的传热和传质分析。当前的流动问题考虑了混合对流应用和饱和多孔空间。传热预测与辐射效应的贡献和热量产生的影响有关。扰动技术用于汇编分析计算。以令人信服的模式确保了求解的准确性。重点分析了参数的影响。预测结果表明，热量和质量格拉肖夫系数以及倾斜角度都会提高速度。传热量随杜富尔数的峰值而增加。结果显示了在传热系统、制造过程、化学反应、核系统、冷却过程等方面的应用。

引用次数: 0

Thermal performance of hybrid base fluid saturated by SWCNTs using length and radius dependent thermal conductivity: Investigation for thermal radiated nanofluid 利用与长度和半径相关的热导率研究 SWCNT 饱和混合基础流体的热性能：热辐射纳米流体研究

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences

Pub Date : 2024-10-10 DOI: 10.1016/j.jrras.2024.101133

Azhar Rasheed , Adnan , Sami Ullah Khan , Dennis Ling Chuan Ching , Ilyas Khan , Wajdi Rajhi , Mohammed A. Tashkandi , Lioua Kolsi , Lotfi Ben Said

The CNTs is an interesting nanomaterials which attained much attention of the researchers. The unique structure of SWCNTs highly alter the performance of fluids saturated by SWCNTs. The base fluid's thermal conductivity enhanced via SWCNTs TCM having

3 μ m \leq L \leq 70 μ m

and

10.0 n m \leq d \leq 40.0 n m

where

R = \frac{d}{2}

is the radius. Hence, the current attempt focuses on the performance of [(C₂H₆O₂-H₂O) 50:50%]/SWCNTs under additional influences of the constraints. The setup is considered through spherical surface with special emphasize on the solar radiation effects. The model nanofluid model developed, investigated numerically and spotlight the key results with comprehensive discussion. It is examined that the velocity increased by optimizing the unsteadiness (

A = 0.1, 0.2, 0.3, 0.4

) in the fluid while the SWCNTs concentration (

ϕ = 0.01, 0.02, 0.03, 0.04

) resist the motion due to considerable viscous and density effects. The significant increase in the thermal behavior is observed for solar radiations (

R d = 0.1, 0.2, 0.3, 0.4

) when the concentration is taken up to

0.04

. These factors would help to acquire the desired temperature by minimizing the SWCNTs amount. The SF enlarges for larger rotational number while rate of thermal rate augmented for more unsteady flow.

碳纳米管是一种有趣的纳米材料，备受研究人员的关注。SWCNTs 的独特结构极大地改变了被 SWCNTs 饱和的流体的性能。3μm≤L≤70μm、10.0nm≤d≤40.0nm（其中 R=d2 为半径）的 SWCNTs TCM 增强了基础流体的导热性。因此，本次尝试的重点是[(C2H6O2-H2O) 50:50%]/SWCNT 在额外约束条件影响下的性能。设置通过球形表面进行考虑，特别强调太阳辐射效应。开发了纳米流体模型，对其进行了数值研究，并重点介绍了关键结果和综合讨论。研究发现，通过优化流体中的不稳定性（A=0.1,0.2,0.3,0.4），速度得到了提高，而 SWCNTs 浓度（j=0.01,0.02,0.03,0.04）由于相当大的粘性和密度效应而抵制了运动。当浓度达到 0.04 时，太阳辐射（Rd=0.1,0.2,0.3,0.4）下的热行为明显增加。这些因素有助于通过尽量减少 SWCNTs 的用量来获得所需的温度。旋转数越大，SF 越大，而热速率越大，流动越不稳定。

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引用次数: 0

The predictive value of contrast-enhanced ultrasonography combined with aspartate aminotransferase-to-lymphocyte ratio in predicting therapeutic efficacy and prognosis of post-transarterial chemoembolization in primary liver cancer 对比增强超声造影结合天冬氨酸氨基转移酶-淋巴细胞比值在预测原发性肝癌经动脉化疗栓塞术后疗效和预后中的预测价值

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences

Pub Date : 2024-10-09 DOI: 10.1016/j.jrras.2024.101111

Zhiyu Hao

Objective

To investigate the predictive value of contrast-enhanced ultrasonography (CEUS) combined with the aspartate aminotransferase-to-lymphocyte ratio (ALRI) in predicting the therapeutic efficacy and prognosis of primary liver cancer after transarterial chemoembolization (TACE).

Methods

We included 75 patients with hepatocellular carcinoma (HCC) who underwent TACE in our oncology department between January 2019 and December 2021. The patients' clinical data, preoperative ALRI, and postoperative CEUS results were analyzed.

Results

The optimal cutoff value of ALRI for predicting residual tumor lesions using digital subtraction angiography (DSA) was 42.50. CEUS had a specificity of 0.92, sensitivity of 0.96, and area under the curve (AUC) of 0.940 for determining residual tumor lesions, while ALRI had a specificity of 0.88, sensitivity of 0.70, and AUC of 0.825. The combination of CEUS and ALRI provided a specificity of 0.92, sensitivity of 0.98, and AUC of 0.985 for determining residual tumor lesions. All patients were followed up continuously after the operation. The optimal cutoff value of ALRI for predicting residual tumor lesions in relation to 3-year survival was 41.50. In terms of 3-year survival prediction, DSA showed a specificity of 0.559, sensitivity of 0.889, and AUC of 0.724, CEUS exhibited a specificity of 0.500, sensitivity of 0.852, and AUC of 0.676, and ALRI had a specificity of 0.618, sensitivity of 0.704, and AUC of 0.611. Combined detection of CEUS and ALRI resulted in a specificity of 0.500, sensitivity of 0.889, and AUC of 0.662 for predicting 3-year survival. Patients with negative DSA results, CEUS-negative patients, and those with ALRI ≤41.5 exhibited significantly better survival outcomes compared to their positive counterparts.

Conclusion

CEUS combined with ALRI yields a higher predictive value in predicting residual tumor lesions and death in patients with HCC after TACE.

目的研究对比增强超声成像（CEUS）结合天冬氨酸氨基转移酶与淋巴细胞比值（ALRI）在预测原发性肝癌经动脉化疗栓塞术（TACE）后疗效和预后方面的预测价值。方法纳入2019年1月至2021年12月期间在我院肿瘤科接受TACE治疗的75例肝细胞癌（HCC）患者。结果使用数字减影血管造影（DSA）预测残留肿瘤病灶的最佳ALRI临界值为42.50。CEUS 对确定残留肿瘤病灶的特异性为 0.92，敏感性为 0.96，曲线下面积 (AUC) 为 0.940，而 ALRI 的特异性为 0.88，敏感性为 0.70，曲线下面积 (AUC) 为 0.825。CEUS 和 ALRI 联合用于确定残留肿瘤病灶的特异性为 0.92，灵敏度为 0.98，AUC 为 0.985。术后对所有患者进行了持续随访。ALRI预测残留肿瘤病灶与3年生存率的最佳临界值为41.50。在预测 3 年生存率方面，DSA 的特异性为 0.559，敏感性为 0.889，AUC 为 0.724；CEUS 的特异性为 0.500，敏感性为 0.852，AUC 为 0.676；ALRI 的特异性为 0.618，敏感性为 0.704，AUC 为 0.611。联合检测 CEUS 和 ALRI 预测 3 年生存率的特异性为 0.500，灵敏度为 0.889，AUC 为 0.662。DSA结果阴性的患者、CEUS结果阴性的患者以及ALRI≤41.5的患者与阳性患者相比，生存率明显更高。

{"title":"The predictive value of contrast-enhanced ultrasonography combined with aspartate aminotransferase-to-lymphocyte ratio in predicting therapeutic efficacy and prognosis of post-transarterial chemoembolization in primary liver cancer","authors":"Zhiyu Hao","doi":"10.1016/j.jrras.2024.101111","DOIUrl":"10.1016/j.jrras.2024.101111","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the predictive value of contrast-enhanced ultrasonography (CEUS) combined with the aspartate aminotransferase-to-lymphocyte ratio (ALRI) in predicting the therapeutic efficacy and prognosis of primary liver cancer after transarterial chemoembolization (TACE).</div></div><div><h3>Methods</h3><div>We included 75 patients with hepatocellular carcinoma (HCC) who underwent TACE in our oncology department between January 2019 and December 2021. The patients' clinical data, preoperative ALRI, and postoperative CEUS results were analyzed.</div></div><div><h3>Results</h3><div>The optimal cutoff value of ALRI for predicting residual tumor lesions using digital subtraction angiography (DSA) was 42.50. CEUS had a specificity of 0.92, sensitivity of 0.96, and area under the curve (AUC) of 0.940 for determining residual tumor lesions, while ALRI had a specificity of 0.88, sensitivity of 0.70, and AUC of 0.825. The combination of CEUS and ALRI provided a specificity of 0.92, sensitivity of 0.98, and AUC of 0.985 for determining residual tumor lesions. All patients were followed up continuously after the operation. The optimal cutoff value of ALRI for predicting residual tumor lesions in relation to 3-year survival was 41.50. In terms of 3-year survival prediction, DSA showed a specificity of 0.559, sensitivity of 0.889, and AUC of 0.724, CEUS exhibited a specificity of 0.500, sensitivity of 0.852, and AUC of 0.676, and ALRI had a specificity of 0.618, sensitivity of 0.704, and AUC of 0.611. Combined detection of CEUS and ALRI resulted in a specificity of 0.500, sensitivity of 0.889, and AUC of 0.662 for predicting 3-year survival. Patients with negative DSA results, CEUS-negative patients, and those with ALRI ≤41.5 exhibited significantly better survival outcomes compared to their positive counterparts.</div></div><div><h3>Conclusion</h3><div>CEUS combined with ALRI yields a higher predictive value in predicting residual tumor lesions and death in patients with HCC after TACE.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"17 4","pages":"Article 101111"},"PeriodicalIF":1.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142425665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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