Journal of Radiation Research and Applied Sciences最新文献

{"title":"Impact of percutaneous transhepatic biliary drainage via different routes under CT guidance on obstructive jaundice","authors":"Chao Lu ,&nbsp;Zhida Long ,&nbsp;Zhixiang Xing,&nbsp;Bo Chen,&nbsp;Peng Zhou,&nbsp;Jiming Hu","doi":"10.1016/j.jrras.2026.102185","DOIUrl":"10.1016/j.jrras.2026.102185","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the postoperative biochemical recovery and complications of computed tomography (CT)-guided Percutaneous Transhepatic Biliary Drainage (PTBD) via left-lobe versus right-lobe approaches for malignant obstructive jaundice.</div></div><div><h3>Methods</h3><div>In this single-center retrospective study, 254 patients were categorized into two groups based on the hepatic access route: the Left-Lobe Group (puncture via segments S2/S3, n = 136) and the Right-Lobe Group (puncture via segments S5/S6 or conventional right pathways, n = 118). The comparison encompassed technical success, procedure-related parameters (number of puncture attempts, fluoroscopy time, total procedure time, radiation dose), postoperative recovery (hospital stay, duration of pain), serial liver function tests (total bilirubin, direct bilirubin, alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], gamma-glutamyl transpeptidase [GGT]) preoperatively and on days 3 and 7, and the incidence of procedure-related complications. Technical success was defined as successful placement of the drainage catheter into the target bile duct, confirmed by post-procedural cholangiography and established bile drainage.</div></div><div><h3>Results</h3><div>The Left-Lobe Group demonstrated a significantly higher technical success rate (89.71 % vs. 77.12 %, P = 0.007), corresponding to an absolute risk difference of 12.6 % (95 % CI: 3.5 %–21.7 %). Postoperatively, this group showed superior recovery: lower AST at 3 days (P = 0.019), lower direct bilirubin at 7 days (P &lt; 0.001), greater decline rates in ALP (P = 0.003) and GGT (P = 0.003) at 7 days. Complication rates were also significantly lower for bile leak (5.88 % vs. 15.25 %, P = 0.014), catheter occlusion (2.94 % vs. 11.02 %, P = 0.010), and pleural effusion (0.74 % vs. 7.63 %, P = 0.013). No major complications (severe hemorrhage requiring intervention or procedure-related mortality) occurred in either group.</div></div><div><h3>Conclusion</h3><div>The left-lobe approach for CT-guided PTBD may be associated with higher technical success, more effective and rapid improvement in liver function, and suggests a lower rate of specific minor complications compared to the right-lobe approach.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102185"},"PeriodicalIF":2.5,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and regulatory mechanisms of biomarkers related to endoplasmic reticulum stress in coronary artery disease","authors":"Hao Nie ,&nbsp;Tingting Yang ,&nbsp;Baishi Wang ,&nbsp;Qifan Sun ,&nbsp;Demin Huo ,&nbsp;Yang Li ,&nbsp;Ruiqin Yang","doi":"10.1016/j.jrras.2026.102184","DOIUrl":"10.1016/j.jrras.2026.102184","url":null,"abstract":"<div><h3>Objective</h3><div>The occurrence of cardiovascular disease is linked to endoplasmic reticulum stress (ERS). Nevertheless, the molecular basis of ERS-related genes (ERSRGs) in coronary artery disease (CAD) remains poorly investigated. This study aimed to assess human CAD transcriptome data, pinpoint and verify ERS-associated hub genes in CAD, and identify biomarkers linked to ERS in CAD.</div></div><div><h3>Methods</h3><div>Candidate genes for CAD were identified by analyzing three datasets. The overlap between differentially expressed genes(DEGs), key module genes from WGCNA, and a specific gene set was investigated. PPI network was then used to refine the biomarkers, and machine learning were used for additional analysis. Then, diagnostic genes were examined using single-gene gene set enrichment analysis (GSEA). Furthermore, the interactions between biomarkers and various immune cells were investigated.Networks regulating miRNA-mRNA-TF relationships and identifying potential interacting chemicals were successfully established. Finally, to further explore the possible involvement of the discovered biomarkers in CAD, RT-qPCR and endoplasmic reticulum stress in vitro model experiments was performed.</div></div><div><h3>Results</h3><div>63 candidate genes were identified through the intersection of DEGs, a specific gene set, and critical module genes. Functional analysis linked them to T cell receptor signaling and Golgi transport.LR, SVM, and XGBoost models based on three biomarkers showed moderate diagnostic capability with AUC &gt;0.6.Experimental validation confirmed that TMED2 and SEC22B were significantly downregulated in a cellular model of ERS in CAD, which was reversed by 4-PBA treatment.Immune infiltration analysis revealed significant correlations with various immune cells. Based on the CTD, some interacting chemicals were predicted such as cyclosporine, which might serve as potential relevance for CAD by targeting the corresponding biomarkers.</div></div><div><h3>Conclusion</h3><div>This study identified three biomarkers, confirming TMED2 and SEC22B as valuable for diagnosing CAD which were the components of COPII vesicle transport system regulating the activation and secretion of ERS sensors. 4-PBA can mitigate ERS-related cellular damage.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102184"},"PeriodicalIF":2.5,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of ginsenoside Rg1 on the proliferation and osteogenic differentiation of human periodontal ligament stem cells mediated by Wnt/Ca2+ signaling pathway","authors":"Tingting Lin ,&nbsp;Qin Qiu ,&nbsp;Wenting Song","doi":"10.1016/j.jrras.2026.102197","DOIUrl":"10.1016/j.jrras.2026.102197","url":null,"abstract":"<div><h3>Background and objective</h3><div>Ginsenoside Rg1 exhibits extensive pharmacological effects on various systems, including the nervous, cardiovascular, digestive, endocrine, and immune systems. This study aimed to investigate the mechanism of ginsenoside Rg1 on the proliferation and osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) mediated by the Wnt/Ca²⁺ signaling pathway.</div></div><div><h3>Materials and methods</h3><div>hPDLSCs were isolated from healthy periodontal tissues of patients undergoing orthodontic treatment and cultured. Immunohistochemical staining utilizing stromal cell antigen-1 (STRO-1) and cluster of differentiation 146 (CD146) employed for cell identification. Cells were rolled into two groups regarding culture conditions: the control group (normal culture) and Rg1 group (cultured with the optimal concentration of 50 μmol/L Rg1 determined by MTT proliferation assay). The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay was utilized to assess cell proliferation activity. The mRNA expression of stemness markers OCT4 and NANOG was evaluated by quantitative real-time polymerase chain reaction (qPCR) in undifferentiated hPDLSCs. Subsequently, osteogenic differentiation was induced utilizing a mineralization induction medium, followed by quantitative real-time polymerase chain reaction for assessment of the expression level of osteogenic-related genes, including Runt-related transcription factor 2 <em>(Runx2)</em>, Collagen1 (<em>COL1A1</em>), Osteopontin (<em>OPN</em>), and Osteocalcin (<em>OCN</em>). Alizarin red staining visualized mineralized nodules, and Western blot determined relative expression level of Wnt/Ca²⁺ signaling pathway proteins, including calcium/calmodulin-dependent protein kinase II (CaMKII) and Nemo-like kinase (NLK).</div></div><div><h3>Results</h3><div>Immunohistochemical staining revealed positive expression of STRO-1 and CD146 in hPDLSCs. Relative to the control group, the Rg1 group exhibited a drastic increase in cell proliferation activity (<em>P</em> &lt; 0.05). Following osteogenic differentiation induction, the area of Alizarin red-stained mineralized nodules was notably greater in the Rg1 group versus the control group. Additionally, expression levels of <em>Runx2</em>, <em>COL1A1</em>, <em>OPN</em>, and <em>OCN</em> were greatly elevated, along with increased protein expression level of CaMKII and NLK (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Ginsenoside Rg1 promotes proliferation and enhances in vitro osteogenic differentiation and mineralization of hPDLSCs, potentially associated with modulation of CaMKII and NLK expression within the Wnt/Ca²⁺ pathway.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102197"},"PeriodicalIF":2.5,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of respiratory function training-based rehabilitation nursing on patients’ recovery of mycoplasma pneumoniae infection based on computed tomography imaging features","authors":"Ruyi Zheng,&nbsp;Hongpeng Chi,&nbsp;Yajing Lin,&nbsp;Xiaowan Zeng","doi":"10.1016/j.jrras.2026.102174","DOIUrl":"10.1016/j.jrras.2026.102174","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to investigate the chest computed tomography (CT) findings of patients with mycoplasma pneumoniae (MP) infection and evaluate the effect of rehabilitation nursing based on respiratory function training (RFT) on patients’ pulmonary function and quality of life (QoL).</div></div><div><h3>Materials and methods</h3><div>One hundred and twenty patients with MP infection were included to analyze the distribution of chest CT signs and their correlation with serum MP antibody titers. According to the rehabilitation nursing methods, the patients were divided into control group (routine nursing, n = 60) and RFT group (respiratory function training, n = 60). The differences of pulmonary function, pulmonary imaging characteristics, and QoL St. George's Respiratory Questionnaire (SGRQ) between admission and discharge were analyzed.</div></div><div><h3>Results</h3><div>The CT signs of MP patients were ground-glass opacity, nodular opacity, and consolidation in 92.5 %, 65.0 %, and 50.8 %, respectively. MP antibody titer was negatively correlated with ground-glass opacity (r = −0.531, <em>P</em> = 0.048) and positively correlated with consolidation (r = 0.729, <em>P</em> = 0.032). These correlations suggest that higher antibody titers may be associated with more advanced parenchymal changes (consolidation) rather than early interstitial changes (ground-glass opacity). Compared with the control group, the RFT group showed a greater improvement in FEV1 % (between-group difference in change: 14.2 %, 95 % CI 10.1–18.3 %, <em>P</em> &lt; 0.001). SGRQ score was significantly decreased (between-group difference: −14.3 points, 95 % CI -18.1 to −10.5, <em>P</em> &lt; 0.001) at discharge.</div></div><div><h3>Conclusion</h3><div>In summary, specific chest CT signs correlate with MP antibody titers, offering adjunct diagnostic insights. Separately, RFT-based rehabilitation nursing significantly enhances pulmonary function, promotes imaging resolution, and contributes to the alleviation of clinical symptoms and promotion of disease recovery in MP pneumonia patients.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102174"},"PeriodicalIF":2.5,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The function and underlying mechanism of matrine in modulating FDX1-mediated copper-induced cell death to facilitate apoptosis in cholangiocarcinoma QBC939 cells","authors":"Linfang Xu,&nbsp;Min Gong,&nbsp;Jialing Li,&nbsp;Xing Li,&nbsp;Wen Liao","doi":"10.1016/j.jrras.2026.102169","DOIUrl":"10.1016/j.jrras.2026.102169","url":null,"abstract":"<div><h3>Background</h3><div>Cholangiocarcinoma (CCA), a highly lethal malignant tumor, currently lacks effective therapeutic options. Matrine, a compound extracted from the traditional Chinese medicinal plant Sophora flavescentis Radix, demonstrates significant anti-tumor properties and the ability to induce programmed cell death. Ferredoxin 1 (FDX1) is a crucial biomolecule involved in mediating copper-induced cell death.</div></div><div><h3>Methods</h3><div>To evaluate the anti-tumor efficacy of matrine in vivo, we developed a BALB/c mouse xenograft model using QBC939 cholangiocarcinoma cells (n = 6 per group). We assessed tumor progression, apoptotic markers, and FDX1 protein levels through a comprehensive panel of analytical methods, including immunohistochemistry, western blotting, TUNEL staining, flow cytometry, and ELISA.</div></div><div><h3>Results</h3><div>This study demonstrates that matrine effectively suppresses the growth of CCA QBC939 cells and promotes cell death in an in vivo setting in a dose-dependent manner. Matrine treatment significantly increased FDX1 expression and markers associated with cuproptosis (Lip-DLST, Lip-DLAT), decreased antioxidant enzyme activities, and enhanced apoptosis-related protein expression. The anti-tumor mechanism of matrine on CCA cells involves the induction of apoptosis, which is associated with the up-regulation of FDX1 expression.</div></div><div><h3>Conclusion</h3><div>These findings suggest that matrine shows therapeutic potential for CCA treatment through its modulation of FDX1-mediated cuproptosis (copper-induced cell death) and subsequent apoptosis induction, providing a rationale for further investigation.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102169"},"PeriodicalIF":2.5,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced indirect sealing of cerebrospinal fluid leaks in anterior cervical surgery using plate mechanical pressure","authors":"Dong Liu,&nbsp;Leisheng Wang,&nbsp;Xiaoguang Fan","doi":"10.1016/j.jrras.2026.102196","DOIUrl":"10.1016/j.jrras.2026.102196","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the effectiveness and safety of the “indirect sealing method” for managing cerebrospinal fluid leakage (CSFL) during anterior cervical spine surgery (ACSS), using magnetic resonance imaging (MRI) imaging.</div></div><div><h3>Methods</h3><div>A retrospective analysis included 30 patients with CSFL during ACSS for ossification of the posterior longitudinal ligament. Patients were divided into the Patch group (application of an artificial dura mater patch + hemostatic gelatin on the dura surface, n = 15) and the Patch + Plate group (artificial dura patch positioned between the vertebral body and the titanium plate, n = 15). Effectiveness was assessed via total CSFL drainage volume, drainage tube duration, and CSFL incidence on MRI at 3 days, 1 month, and 3 months postoperatively. Safety was evaluated based on sealing-related and surgery-related complications. Surgical efficacy was measured using modified Japanese orthopedic association score (mJOA), visual analog scale (VAS), and neck disability index (NDI) scores preoperatively and at 3 months, along with time to ambulation and total hospital stay.</div></div><div><h3>Results</h3><div>The Patch + Plate group had significantly lower total CSFL drainage volume (P = 0.004) and shorter drainage tube duration (P = 0.005). CSFL incidence was lower in the Patch + Plate group at 3 days (P = 0.003), 1 month (P = 0.015), and 3 months (P = 0.015). Low intracranial pressure headache (P = 0.002) was lower in the Patch + Plate group. At 3 months, the Patch + Plate group showed better mJOA (P = 0.038), VAS (P = 0.025), and NDI (P = 0.044) scores, as well as shorter time to ambulation (P = 0.041) and total hospital stay (P = 0.031).</div></div><div><h3>Conclusion</h3><div>Placing the patch between the titanium plate and the vertebral body to achieve a tight seal using the mechanical pressure of the titanium plate can improve sealing effectiveness, reduces CSFL-related complications, and enhances postoperative recovery in ACSS.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102196"},"PeriodicalIF":2.5,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV16 E6 gene polymorphisms and the mechanisms by which L83V promotes the progression of cervical lesions in Xinjiang","authors":"Yang Li ,&nbsp;Yuhua Liu ,&nbsp;Reyilanmu Maisaidi ,&nbsp;Siqi Li ,&nbsp;Zhixiang Fan ,&nbsp;Lili Han","doi":"10.1016/j.jrras.2026.102183","DOIUrl":"10.1016/j.jrras.2026.102183","url":null,"abstract":"<div><h3>Objective</h3><div>Cervical cancer (CC) is a prevalent malignant neoplasm in the female population. The oncogenicity of HPV is closely associated with HPV variations.</div></div><div><h3>Methods</h3><div>The E6 sequences of HPV16-positive samples were subjected to PCR amplification. The PCR products were sequenced and used for variation analysis, phylogenetic analysis, and analysis of selective pressure. Previously experimentally validated T-cell epitopes encompassing the 83L site were retrieved from the IEDB database. The changes in the affinity of T-cell epitopes and MHC-I/II were predicted after L83V. Wild and mutant antigen peptides were synthesized as EYRHYCYSL and EYRHYCYSV, respectively. Mature dendritic cells (DCs) from peripheral blood samples were stimulated with synthesized antigen peptides, and cluster of differentiation (CD) markers and cytokines were detected.</div></div><div><h3>Results</h3><div>Six distinct non-synonymous nucleotide mutations were identified, which manifested as eight different variation patterns (including single and co-mutation profiles), all of which belonged to Lineage A. 25D and 83L sites were positively selected sites. L83V affected 4 T-cell epitopes, leading to reduced affinity with MHC-I/II. Compared with the wild antigen peptide, the ratios of CD80, CD83, and CD86 decreased significantly (<em>p</em> &lt; 0.05), and the concentrations of IFN-γ, IL-6, IL-10, TGF-β, and TNF-α decreased significantly (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study provides novel mechanistic evidence that the prevalent L83V polymorphism may promote the progression of cervical lesions in Xinjiang by disrupting T-cell epitopes and facilitating immune evasion.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102183"},"PeriodicalIF":2.5,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of NORM and heavy metal risks from breakfast cereals consumed in the Kurdistan Region, Iraq","authors":"Halmat J. Hassan ,&nbsp;Farhad A. Hama Hassan","doi":"10.1016/j.jrras.2026.102186","DOIUrl":"10.1016/j.jrras.2026.102186","url":null,"abstract":"<div><div>This study analyses 22 commercially available cereal samples containing naturally occurring radioactive materials, imported and sold in major retailers within the Kurdistan Region, Iraq. Gamma-ray spectrometry and X-ray fluorescence were employed to assess radiological risk associated with cereal consumption. The activity concentrations of radionuclides ranged from 1.6 ± 0.35 to 68.5 ± 11.5 <span><math><mrow><msup><mrow><mspace></mspace><mtext>Bq</mtext><mspace></mspace><mtext>kg</mtext></mrow><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span> for ²³⁸U, 2.3 ± 0.24 to 96.4 ± 7.5 <span><math><mrow><msup><mrow><mspace></mspace><mtext>Bq</mtext><mspace></mspace><mtext>kg</mtext></mrow><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span> for ²³²Th, and 67.8 ± 5.2 to 1448 ± 92 <span><math><mrow><msup><mrow><mspace></mspace><mtext>Bq</mtext><mspace></mspace><mtext>kg</mtext></mrow><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span> for ⁴⁰K. Estimated annual effective doses were 59.07, 365.9, and 30.055 <span><math><mrow><mi>μ</mi><mtext>Sv</mtext><mspace></mspace><msup><mi>y</mi><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span> for ²³⁸U, ²³²Th, and ⁴⁰K, respectively, based on an assumed annual cereal intake of 5 kg for adults and 3.7 kg for children. Samples S4 and S5 exhibited the highest total AED, at 388.3 and 331.8 <span><math><mrow><mi>μ</mi><mtext>Sv</mtext><mspace></mspace><msup><mi>y</mi><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span>, respectively. The total effective dose of these samples surpasses the general public reference level of 290 <span><math><mrow><mi>μ</mi><mtext>Sv</mtext><mspace></mspace><msup><mi>y</mi><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span>, indicating unsuitability for consumption. The Pb concentrations in samples S8 and S17 markedly exceed the Codex international limit of 6 mg <span><math><mrow><msup><mtext>kg</mtext><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span>, reaching 25.6 and 31.7 mg <span><math><mrow><msup><mtext>kg</mtext><mrow><mo>−</mo><mn>1</mn></mrow></msup></mrow></math></span>, respectively. These findings suggest that food regulations should address potential radiation exposure from cereals to mitigate public health risks.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102186"},"PeriodicalIF":2.5,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric impact of vacuum bag vs. abdominal compression fixation on PTV margins in IMRT for hepatocellular carcinoma with lymph node metastasis","authors":"Zhenghuan Li ,&nbsp;Fantu Kong ,&nbsp;Manya Wu ,&nbsp;Eryan Sun ,&nbsp;Zhi Zhong ,&nbsp;Chao Wang ,&nbsp;Ru Wang ,&nbsp;Yadi He ,&nbsp;Pan Liu ,&nbsp;Jie Dong ,&nbsp;Huamei Yan ,&nbsp;Gaokui He","doi":"10.1016/j.jrras.2026.102166","DOIUrl":"10.1016/j.jrras.2026.102166","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare setup errors between vacuum-bag with thermoplastic shell (VB) and abdominal compression with foam (AC) immobilization techniques in radiotherapy for hepatocellular carcinoma (HCC) with lymph node metastases (LNM), and evaluate their impacts on planning target volume (PTV) margins and dosimetry.</div></div><div><h3>Methods</h3><div>This retrospective cohort study of 34 HCC patients with LNM (VB group: n = 17; AC group: n = 17) was performed. Setup errors were verified by cone-beam CT (CBCT), and PTV margins were calculated using the van Herk formula (MPTV = 2.5Σ+0.7σ). Dosimetric parameters (conformity index, CI; homogeneity index, HI) and organ-at-risk (OAR) doses were compared.</div></div><div><h3>Results</h3><div>The VB group demonstrated significantly smaller calculated PTV margins in the superior-inferior (Y-axis) direction (0.32 cm vs. 0.57 cm, p = 0.001). Systematic errors (Σ) were lower for VB in the X and Y axes, while random errors (σ) were lower in the Z-axis. Dosimetrically, the VB group achieved significantly better dose conformity (CI: 0.24 ± 1.09 % vs. −0.76 ± 1.50 %, p = 0.04). No statistically significant differences were observed in other PTV parameters (Dmax, Dmean, TC, HI) or in the majority of OAR dose parameters, although a trend favoring VB was noted in several instances (e.g., Liver V30, p = 0.04).</div></div><div><h3>Conclusion</h3><div>For HCC patients with LNM undergoing IMRT, vacuum bag fixation significantly reduces PTV margins along the superior-inferior direction and improves dose conformity compared to abdominal compression, offering a potential for optimized treatment planning.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102166"},"PeriodicalIF":2.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging semi-quantitative evaluation of cartilage damage in patients with knee osteoarthritis","authors":"Songbin Yang ,&nbsp;Xu Cui ,&nbsp;Maohua Pang ,&nbsp;Dandan Lv ,&nbsp;Jichun Wu ,&nbsp;Ying Li ,&nbsp;Juhua Zhang","doi":"10.1016/j.jrras.2026.102173","DOIUrl":"10.1016/j.jrras.2026.102173","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to develop and validate an improved U-Net model for optimizing knee MRI reconstruction and used these optimized images to perform semi-quantitative assessments of cartilage damage severity in patients with knee osteoarthritis (KOA), as well as to explore the association between cartilage damage and subchondral bone marrow edema.</div></div><div><h3>Methods</h3><div>The improved U-shaped network (U-net) was utilized for optimizing the MRI images, and the network reconstruction time, structural similarity index measure (SSIM), and peak signal-to-noise ratio (PSNR) were analyzed. 108 patients with KOA who underwent magnetic resonance examination were included as the research objects. After the patients were divided into normal, mild, and severe groups, their grades of semi-quantitative evaluation of cartilage damage were analyzed.</div></div><div><h3>Results</h3><div>The SSIM of the improved U-net was significantly higher than that of the original U-net, and the difference between the reconstructed images and the original images was highly reduced. MRI could show the types of cartilage damage in the knee joint. An MRI system with the improved U-net model improved the quality of MRI images of KOA patients. The improved U-net achieved a mean PSNR of 42.7 dB and SSIM of 0.94 at a 20 % sampling rate, representing a 15 % and 10 % improvement over the standard U-net, respectively. After the improvement, the reconstruction time of the U-net became shorter. There was a statistically significant difference in the probability of cartilage injury grades I–IV occurring among subchondral bone marrow edema grades 1–3 (<em>Z</em> = 5.098, <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The semi-quantitative MRI assessment facilitated by the improved U-net shows promise for accurately displaying and grading articular cartilage damage in KOA. Further validation against arthroscopic findings and in multi-center cohorts is warranted before clinical adoption can be considered. In conclusion, the improved U-net provided knee MRI reconstructions with superior quantitative quality and speed. Using these images, semi-quantitative assessment revealed a significant association between the severity of subchondral bone marrow edema and cartilage injury grade, demonstrating the method's potential for structured image evaluation in KOA.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102173"},"PeriodicalIF":2.5,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}