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Dose-effect analysis of 60Co-γ radiation on Astragalus membranaceus across life cycle and creation of high-flavonoid/super-biomass germplasm 60Co-γ辐射对黄芪全生命周期及高黄酮/超生物量种质形成的剂量效应分析
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2025-12-30 DOI: 10.1016/j.jrras.2025.102149
Ming Jiang , Zun Lv , Jiajia Chen , Yue Pan , Ying Yu , Kanchao Yu , Lijuan Xia , Jicheng Liu , Hui Li , Keyong Zhang

Objectives

This study aimed to systematically investigate the dose-dependent effects of 60Co-γ radiation on the entire growth cycle of Astragalus membranaceus, using a dose gradient ranging from 50 to 400 Gy. The specific objectives were to evaluate its impacts on seed germination, seedling physiology, agronomic traits of one-year-old plants, and the accumulation of medicinal components.

Methods

A radiation dose gradient of 50–400 Gy was applied to Astragalus membranaceus seeds. Assessments included seed germination and seedling emergence rates, physiological and biochemical markers (e.g., antioxidant enzyme activities and secondary metabolites), agronomic traits, and medicinal compound accumulation. The median lethal dose (LD50) was calculated, and a multi-trait weighted index (I) was used to screen superior germplasm lines.

Results

Low-dose radiation (50–100 Gy) significantly improved seed germination and emergence rates, while high doses (≥200 Gy) were inhibitory, with an LD50 of 201.95 Gy. At 50 Gy, antioxidant defense mechanisms were activated, indicated by increased CAT and APX activities, and flavonoid content rose by 48.2 %. Doses≥300 Gy caused severe damage, including a 57.8 % reduction in thylakoid density. In one-year-old plants, 50 Gy synergistically improved biomass and active compound content. Doses of 100–300 Gy induced transgressive segregation: one line (300 Gy-2) showed a root dry weight 4.63 times that of the control. Using a multi-trait index, seven superior lines were selected. Line 100 Gy-8 exhibited a 1.54-fold increase in total flavonoids (93.03 mg/g), while line 400 Gy-12 showed a threefold enhancement.

Conclusion

The results indicate that 50 Gy is an optimal dose for simultaneously improving yield and quality in Astragalus membranaceus, whereas the 100–300 Gy range serves as a promising mutagenic window for generating high-flavonoid or high-biomass variants. This study provides theoretical support and core germplasm resources for targeted breeding strategies.
目的采用50 ~ 400 Gy剂量梯度,系统研究60Co-γ辐射对黄芪整个生长周期的剂量依赖性。具体目的是评价其对一年生植物种子萌发、幼苗生理、农艺性状和药用成分积累的影响。方法对黄芪种子进行50 ~ 400 Gy剂量梯度辐射。评估包括种子发芽和出苗率、生理生化指标(如抗氧化酶活性和次生代谢物)、农艺性状和药用化合物积累。计算中位致死量(LD50),采用多性状加权指数(I)筛选优良种质系。结果低剂量辐射(50 ~ 100 Gy)显著提高种子萌发率和出苗率,高剂量辐射(≥200 Gy)抑制种子萌发,LD50为201.95 Gy。在50 Gy下,抗氧化防御机制被激活,表现为CAT和APX活性升高,类黄酮含量升高48.2%。剂量≥300 Gy造成严重损害,包括类囊体密度降低57.8%。在一年生植株中,50 Gy可协同提高生物量和活性化合物含量。100-300 Gy的剂量诱导了越界分离:一条线(300 Gy-2)的根干重是对照的4.63倍。利用多性状指数筛选7个优良品系。总黄酮含量增加了1.54倍(93.03 mg/g), 400 Gy-12增加了3倍。结论50 Gy是同时提高黄芪产量和品质的最佳剂量,而100-300 Gy是产生高黄酮或高生物量变异的理想诱变窗口。该研究为有针对性的育种策略提供了理论支持和核心种质资源。
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引用次数: 0
Effect of MgO on the structural, optical, and radiation shielding behavior of multi-component borate glass MgO对多组分硼酸盐玻璃结构、光学和辐射屏蔽性能的影响
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2025-12-17 DOI: 10.1016/j.jrras.2025.102110
Samar Al-Shehri , Nawal K. Almaymoni , Nuha Al-Harbi , Mona Mahmoud , Kottakkaran Sooppy Nisar , Wedad R. Alharbi , Hosam M.G. Al-Qatlawi , Sarah M. Kamil , Ahmad S. Abu-Khadra , A.M. Abdel-Ghany
This study investigates the influence of the replacement of B2O3 with MgO on the structural, optical, and radiation shielding properties of borate-based glasses. Three samples were prepared based on the chemical formula (77.5 – x) mol% B2O3 + 2.5 mol% V2O5 + 2.5 mol% CeO2 + 10 mol% PbO + 7.5 mol% Na2O + x mol% MgO (x = 0, 1.25, and 2.5). As the content of MgO increased, it was observed an enhancement in glass transparency and improved surface uniformity. Based on the Fourier transform inferred, FTIR, spectral analysis the network polymerization has been confirmed. Also, a conversion of BO3 to BO4 has been observed. Optical sherardization has been achieved using the UV–Vis spectra measurements. The results showed a reduction in both transmittance and optical energy gap as the MgO content increased. While the value experimental measured density increased from 1.78 to 2.16 g/cm3. Also, the glass packing efficiency increased from 54 % to >65 %, which confirmed improved structural compactness. Radiation shielding parameters, calculated using XCOM at 0.662, 1.173, and 1.333 MeV, showed enhanced LAC and reduced HVL. It was found that, the sample with 2.5 mol% MgO exhibited the best shielding performance. In general, while these glasses do not surpass lead or commercial high-density glasses in shielding efficiency, they significantly outperform concrete. based on the findings, the prepared samples show competitive performance relative to some polymer-based shields. This supports the MgO-containing borate glasses for use in optical, radiation shielding, and biomedical applications.
本文研究了MgO取代B2O3对硼酸盐基玻璃的结构、光学和辐射屏蔽性能的影响。根据化学式(77.5 - x) mol% B2O3 + 2.5 mol% V2O5 + 2.5 mol% CeO2 + 10 mol% PbO + 7.5 mol% Na2O + x mol% MgO (x = 0,1.25和2.5)制备了3种样品。随着MgO含量的增加,玻璃透明度增强,表面均匀性改善。基于傅里叶变换推断,FTIR,光谱分析证实了网络聚合。此外,还观察到BO3向BO4的转化。利用紫外可见光谱测量实现了光学渗矿化。结果表明,随着MgO含量的增加,透光率和光能隙均降低。而实验测得的密度值由1.78 g/cm3增加到2.16 g/cm3。此外,玻璃填充效率从54%提高到65%,这证实了结构致密性的改善。在0.662、1.173和1.333 MeV下使用XCOM计算的辐射屏蔽参数显示LAC增强,HVL降低。结果表明,添加2.5 mol% MgO的样品具有最佳的屏蔽性能。一般来说,虽然这些玻璃的屏蔽效率不超过铅或商用高密度玻璃,但它们的性能明显优于混凝土。根据研究结果,制备的样品相对于一些聚合物基屏蔽物表现出竞争性的性能。这支持含镁硼酸盐玻璃用于光学,辐射屏蔽和生物医学应用。
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引用次数: 0
Radiological safety assessment of packaged bottle drinking water in India – Age dependent analysis 印度包装瓶装饮用水的放射性安全评价——年龄相关分析
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2025-12-19 DOI: 10.1016/j.jrras.2025.102128
Mahasin Gazi , Arindam Kumar Naskar , Argha Deb
Radioactive radon (222Rn) concentrations in 121 different brands of packaged bottle drinking water (PBDW) samples from different states of India have been assessed in the present study using a potable AlphaGUARD radon monitor along with AlphaGUARD aqua kit. Among the collected samples, the production sites of 72 number of PBDW samples are different places of West Bengal and the remaining 49 samples are different places of other different states of India. Thus, assessing the radon levels in different brands of packaged drinking water that are accessed from most parts of India gives a general picture of the 222Rn concentrations in packaged bottled drinking water throughout India.
Measured radon concentration levels vary between 0.19 and 5.81 Bq/l with an average value of 1.36 Bq/l. Radon concentration of no sample has exceeded the WHO, IAEA and EU Commission prescribed reference level of 100 Bq/l or even USEPA's proposed MCL (11.11 Bq/l).
The measured radon concentrations of the collected samples manifest no significant correlation with either Total Dissolved Solids (TDS) or pH values of the samples.
Annual effective dose (AED) due to radon from these bottled drinking water for three age groups namely infants, children and adults are found to vary between 0.66 and 20.00 μSv/y with a mean of 4.68 ± 0.29 μSv/y, 0.82–25.00 μSv/y with a mean of 5.84 ± 0.36 μSv/y and 0.73–22.30 μSv/y with a mean of 5.21 ± 0.32 μSv/y respectively. Assessment of dose shows that total annual effective dose to the children is the highest among the age groups. No sample has exceeded the WHO, ICRP and the EU commission proposed reference dose limit of 100 μSv/y.
本研究使用便携式AlphaGUARD氡监测仪和AlphaGUARD aqua试剂盒对来自印度不同邦的121种不同品牌包装瓶装饮用水(PBDW)样品中的放射性氡(222Rn)浓度进行了评估。在收集到的样品中,72个PBDW样品的生产地点位于西孟加拉邦的不同地方,其余49个样品位于印度其他不同邦的不同地方。因此,对从印度大部分地区获取的不同品牌包装饮用水中的氡水平进行评估,可以大致了解印度各地包装瓶装饮用水中222Rn的浓度。测得的氡浓度水平在0.19至5.81 Bq/l之间,平均值为1.36 Bq/l。没有样品的氡浓度超过世界卫生组织、国际原子能机构和欧盟委员会规定的100 Bq/l的参考水平,甚至超过美国环保署提出的MCL (11.11 Bq/l)。所采集样品的氡浓度与样品的总溶解固形物(TDS)或pH值均无显著相关性。对婴幼儿、儿童和成人3个年龄组的氡年有效剂量分别为0.66 ~ 20.00 μSv/y,平均值为4.68±0.29 μSv/y, 0.82 ~ 25.00 μSv/y,平均值为5.84±0.36 μSv/y, 0.73 ~ 22.30 μSv/y,平均值为5.21±0.32 μSv/y。剂量评估表明,儿童的年总有效剂量在各年龄组中最高。没有样品超过世界卫生组织、ICRP和欧盟委员会提出的100 μSv/y的参考剂量限值。
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引用次数: 0
Construction of a nanobismuth-loaded hydroxyapatite coating on titanium surface and its antibacterial-osteogenic performance study 钛表面纳米铋负载羟基磷灰石涂层的构建及其抗菌成骨性能研究
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-01-17 DOI: 10.1016/j.jrras.2026.102179
Xue Zhong, Yuhang Song, Zhen Wang

Objectives

Peri-implantitis and early osseointegration at the implant interface are critical challenges in dental implantation. An effective strategy to tackle these issues involves loading bioactive components onto the titanium surface and controlling their release. This research utilizes phase-transited lysozyme (PTL)to functionalize implant titanium surfaces, with the objective of fabricating a hydroxyapatite coating infused with bismuth nanoparticles to inhibit bacterial colonization and promote osteogenesis in vitro, thereby addressing key factors in the prevention of peri-implantitis.

Methods

First, use PTL to modify the surface of pristine titanium. On this basis, prepare a hydroxyapatite coating through the biomimetic mineralization method. Then, load the bismuth nanoparticles onto the titanium sheet by electrostatic adsorption. Finally, obtain a bismuth-loaded hydroxyapatite composite coating.

Results

Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS) analyses confirmed that hydroxyapatite and bismuth nanoparticle composite coatings had been successfully laid down on modified titanium substrates with PTL treatment. SEM and transmission electron microscope (TEM) images revealed the microstructural characteristics of the coatings and the size distribution of the spherical BiNPs (approximately 20–30 nm). Bacterial assays and confocal microscopy observations demonstrated that the bismuth-loaded samples possessed potent early-stage antibacterial activity, effectively inhibiting both planktonic and adherent bacterial viability over a 5-day period, though efficacy gradually decreased over time. Laboratory cell tests indicated the coated titanium discs demonstrated minimal cytotoxicity and positively influenced osteoblast proliferation and adhesion, indicative of favorable biocompatibility.

Conclusion

The resultant Ti-HA-BiNPs coating conferred both enhanced antibacterial properties (>90 % initial inhibition) and osteogenic promotion, offering a promising dual-functional strategy for the prevention of peri-implantitis and enhancement of implant stability in the early postoperative period.
目的:种植体周围炎和种植体界面早期骨融合是种植体种植的关键问题。解决这些问题的有效策略包括将生物活性成分加载到钛表面并控制其释放。本研究利用相转移溶菌酶(PTL)对种植体钛表面进行功能化,目的是制备一种注入铋纳米粒子的羟基磷灰石涂层,以抑制细菌定植并促进体外成骨,从而解决预防种植体周围炎的关键因素。方法首先采用PTL对原始钛进行表面修饰。在此基础上,通过仿生矿化法制备羟基磷灰石涂层。然后,通过静电吸附将铋纳米粒子加载到钛片上。最后,得到负载铋的羟基磷灰石复合涂层。结果扫描电镜(SEM)、能量色散x射线能谱(EDX)和x射线光电子能谱(XPS)分析证实,羟基磷灰石和铋纳米颗粒复合涂层经PTL处理后成功沉积在改性钛基体上。扫描电子显微镜(SEM)和透射电子显微镜(TEM)图像显示了涂层的微观结构特征和球形BiNPs的尺寸分布(约20-30 nm)。细菌分析和共聚焦显微镜观察表明,含铋样品具有有效的早期抗菌活性,在5天的时间内有效地抑制浮游细菌和附着细菌的活力,但随着时间的推移,效果逐渐下降。实验室细胞测试表明,涂层钛盘表现出最小的细胞毒性,并积极影响成骨细胞的增殖和粘附,表明良好的生物相容性。结论制备的Ti-HA-BiNPs涂层具有增强的抗菌性能(90%的初始抑制作用)和促进成骨的双重功能,在术后早期预防种植体周围炎和增强种植体稳定性方面具有良好的双重功能。
{"title":"Construction of a nanobismuth-loaded hydroxyapatite coating on titanium surface and its antibacterial-osteogenic performance study","authors":"Xue Zhong,&nbsp;Yuhang Song,&nbsp;Zhen Wang","doi":"10.1016/j.jrras.2026.102179","DOIUrl":"10.1016/j.jrras.2026.102179","url":null,"abstract":"<div><h3>Objectives</h3><div>Peri-implantitis and early osseointegration at the implant interface are critical challenges in dental implantation. An effective strategy to tackle these issues involves loading bioactive components onto the titanium surface and controlling their release. This research utilizes phase-transited lysozyme (PTL)to functionalize implant titanium surfaces, with the objective of fabricating a hydroxyapatite coating infused with bismuth nanoparticles to inhibit bacterial colonization and promote osteogenesis in vitro, thereby addressing key factors in the prevention of peri-implantitis.</div></div><div><h3>Methods</h3><div>First, use PTL to modify the surface of pristine titanium. On this basis, prepare a hydroxyapatite coating through the biomimetic mineralization method. Then, load the bismuth nanoparticles onto the titanium sheet by electrostatic adsorption. Finally, obtain a bismuth-loaded hydroxyapatite composite coating.</div></div><div><h3>Results</h3><div>Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS) analyses confirmed that hydroxyapatite and bismuth nanoparticle composite coatings had been successfully laid down on modified titanium substrates with PTL treatment. SEM and transmission electron microscope (TEM) images revealed the microstructural characteristics of the coatings and the size distribution of the spherical BiNPs (approximately 20–30 nm). Bacterial assays and confocal microscopy observations demonstrated that the bismuth-loaded samples possessed potent early-stage antibacterial activity, effectively inhibiting both planktonic and adherent bacterial viability over a 5-day period, though efficacy gradually decreased over time. Laboratory cell tests indicated the coated titanium discs demonstrated minimal cytotoxicity and positively influenced osteoblast proliferation and adhesion, indicative of favorable biocompatibility.</div></div><div><h3>Conclusion</h3><div>The resultant Ti-HA-BiNPs coating conferred both enhanced antibacterial properties (&gt;90 % initial inhibition) and osteogenic promotion, offering a promising dual-functional strategy for the prevention of peri-implantitis and enhancement of implant stability in the early postoperative period.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"19 1","pages":"Article 102179"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new three-parameter statistical distribution with applications to biomedical and radiation data 一种新的三参数统计分布及其在生物医学和辐射数据中的应用
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-01-19 DOI: 10.1016/j.jrras.2026.102167
Mohammed Ibrahim AlTwijri , Norah D. Alshahrani , Mohammed Elgarhy , Mahmoud Elsehetry , Bassant Elkalzah
In this paper, we present a new extension of the power Komal distribution (PKD), an original modification of the PKD. The new suggested model is called the half-logistic power Komal distribution (HLPKD). This modified distribution keeps the original PKD simple while providing more flexibility and accuracy when modeling data. The HLPKD has numerous statistical characteristics, including right-skewed, decreased and unimodal probability density functions, skewness, kurtosis moments, incomplete moments, and order statistics. We illustrate the HLPKD’s effectiveness and dependability using the maximum likelihood standard parameter estimate technique and a complete simulation exercise. From the simulation results, we can note that the bias, relative bias, mean square error, root mean square error and average length values decrease as the sample size increases Furthermore, implementing the HLPKD to two real-life biomedical/radiation datasets illustrates its usefulness. It can outperform well-known models as power Komal, Komal, power length-biased new xLindley, power Lindley, power Zeghdoudi, half-logistic new Weibull Pareto, half logistic Weibull, and half logistic exponential distributions.
本文提出了幂Komal分布(PKD)的一个新的扩展,它是PKD的一个原始修改。新提出的模型被称为半logistic功率Komal分布(HLPKD)。这个修改后的分布保持了原始PKD的简单性,同时在建模数据时提供了更多的灵活性和准确性。HLPKD具有许多统计特征,包括右偏斜、减少和单峰概率密度函数、偏度、峰度矩、不完全矩和阶统计量。我们使用最大似然标准参数估计技术和完整的模拟练习来说明HLPKD的有效性和可靠性。从仿真结果可以看出,偏差、相对偏差、均方误差、均方根误差和平均长度值随着样本量的增加而减小。此外,将HLPKD应用于两个真实的生物医学/辐射数据集说明了它的实用性。它优于幂Komal、Komal、幂长度偏置的new xLindley、幂Lindley、幂Zeghdoudi、半logistic新Weibull Pareto、半logistic Weibull和半logistic指数分布等知名模型。
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引用次数: 0
CALB1 inhibits ferroptosis in laryngeal carcinoma via targeting Ca2+-IP3R on mitochondria-associated membranes CALB1通过靶向线粒体相关膜上的Ca2+-IP3R抑制喉癌铁下垂
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI: 10.1016/j.jrras.2026.102209
Zhihai Li , Qiaozhi Jin , Yana Sun , Yilong Wang , Jisheng Liu

Background

Laryngeal cancer, a malignancy arising from the laryngeal mucosal epithelium, threatens human health; hoarseness is often an early sign. Ferroptosis, defined by iron-dependent lipid peroxidation, has emerged as a key cell death modality in cancer. This study investigated whether CALB1 regulates ferroptosis in laryngeal cancer by targeting Ca2+-IP3R signaling at mitochondria-associated membranes (MAMs).

Methods

Normal laryngeal epithelial (16HBE) and laryngeal carcinoma (TU177) cells were used. CALB1 expression and its impact on chemosensitivity were assessed by Western blotting, qRT-PCR, CCK-8, and flow cytometry. Ferroptosis was evaluated by measuring intracellular Fe2+, malondialdehyde (MDA), and reactive oxygen species (ROS). ELISA and co-immunoprecipitation (Co-IP) were employed to examine CALB1 modulation of the Ca2+-IP3R pathway. Mitochondrial function and antioxidant status were analyzed by mitochondrial membrane potential and activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)

Results

CALB1 was upregulated in TU177 versus 16HBE cells and conferred chemoresistance: following cisplatin, CALB1-high cells showed increased survival with reduced apoptosis. CALB1 knockdown decreased GPX4 and enhanced ferroptosis, evidenced by elevated intracellular Fe2+, MDA, and ROS; these changes were reversed by the ferroptosis inhibitor Fer-1, which restored protein expression and reduced oxidative damage. Co-IP revealed CALB1–IP3R interaction. Loss of CALB1 disrupted mitochondrial membrane potential and diminished SOD and GSH-Px activities, effects alleviated by the IP3R inhibitor 2-APB, supporting a role for IP3R-mediated Ca2+ flux in CALB1-dependent ferroptosis control.

Conclusions

CALB1 inhibits ferroptosis in laryngeal cancer cells by suppressing IP3R-mediated Ca2+ signaling and maintaining the homeostasis of mitochondrial function, iron metabolism, and antioxidant system. These findings suggest that the CALB1–IP3R regulatory axis may serve as a potential therapeutic target for enhancing ferroptosis-based treatments in laryngeal cancer.
喉癌是一种起源于喉部粘膜上皮的恶性肿瘤,威胁着人类的健康;声音嘶哑往往是早期征兆。铁死亡,由铁依赖性脂质过氧化定义,已成为癌症中关键的细胞死亡方式。本研究探讨CALB1是否通过靶向线粒体相关膜(MAMs)上的Ca2+-IP3R信号调控喉癌铁下垂。方法使用正常喉上皮细胞(16HBE)和喉癌细胞(TU177)。采用Western blotting、qRT-PCR、CCK-8和流式细胞术评估CALB1表达及其对化疗敏感性的影响。通过测量细胞内Fe2+、丙二醛(MDA)和活性氧(ROS)来评估铁下垂。ELISA和共免疫沉淀(Co-IP)检测CALB1对Ca2+-IP3R通路的调节作用。通过线粒体膜电位、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性分析线粒体功能和抗氧化状态。结果与16HBE细胞相比,TU177细胞中calb1表达上调,并产生化疗耐药:顺铂治疗后,calb1高表达的细胞存活率增加,凋亡减少。CALB1敲除降低GPX4,增强铁下垂,细胞内Fe2+、MDA和ROS升高;这些变化被铁下垂抑制剂fer1逆转,恢复蛋白表达并减少氧化损伤。Co-IP显示CALB1-IP3R相互作用。CALB1的丢失破坏了线粒体膜电位,降低了SOD和GSH-Px活性,IP3R抑制剂2-APB减轻了这种影响,支持IP3R介导的Ca2+通量在CALB1依赖性铁死亡控制中的作用。结论scalb1通过抑制ip3r介导的Ca2+信号,维持线粒体功能、铁代谢和抗氧化系统的稳态,抑制喉癌细胞铁上吊。这些发现表明CALB1-IP3R调控轴可能作为一个潜在的治疗靶点,以增强基于铁中毒的喉癌治疗。
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引用次数: 0
A new heavy-tailed distribution: Its heavy-tailed characteristics with implementations in the radiation and music engineering 一种新的重尾分布:其重尾特征及其在辐射和音乐工程中的实现
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2025-12-05 DOI: 10.1016/j.jrras.2025.102104
Yuyun Huang , Salah Eldden Omer Ali
Recognizing the significant influence that data analysis tools have in diverse fields, we present an innovative analytical approach to enhance and expand the existing variety of distribution methods. Our work centers on combining the inverse Lomax distribution with a recognized distributional approach, leading to what we call the new heavy-tailed inverse Lomax (NHTI-Lomax) distribution. The NHTI-Lomax distribution is able to capture the key characteristics linked to heavy-tailed distributions. This fact is supported by both visual illustrations and thorough mathematical proof. The identifiability features and the heavy-tailed characteristics of the NHTI-Lomax distribution are thoroughly examined and mathematically verified. Furthermore, we obtain the maximum likelihood estimators relevant to this distribution. Additionally, we conduct an analysis of the NHTI-Lomax distribution’s effectiveness with simulated data, allowing us to assess its practical relevance and performance across different situations. In practical terms, the significance of the NHTI-Lomax distribution is evaluated using perspectives from real-world data. The first application pertains to music engineering. While, the second application focuses on the field of radiation sciences. By employing certain established information criteria, we show that the NHTI-Lomax distribution outperforms certain alternative distributions.
认识到数据分析工具在不同领域的重要影响,我们提出了一种创新的分析方法来增强和扩展现有的各种分布方法。我们的工作集中在将反Lomax分布与公认的分布方法相结合,导致我们称之为新的重尾反Lomax (NHTI-Lomax)分布。NHTI-Lomax分布能够捕捉到与重尾分布相关的关键特征。这一事实既有直观的说明,也有详尽的数学证明。研究了NHTI-Lomax分布的可识别性特征和重尾特征,并进行了数学验证。进一步,我们得到了与该分布相关的极大似然估计量。此外,我们还利用模拟数据对NHTI-Lomax分布的有效性进行了分析,从而评估其在不同情况下的实际相关性和性能。在实践中,NHTI-Lomax分布的意义是用现实世界数据的角度来评估的。第一个应用与音乐工程有关。而第二种应用则集中在辐射科学领域。通过采用某些既定的信息标准,我们表明NHTI-Lomax分布优于某些替代分布。
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引用次数: 0
An innovative data analysis method with theoretical foundation: Its pertinence in the realms of radiation and accounting 一种具有理论基础的创新数据分析方法:在辐射和会计领域的针对性
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2025-12-13 DOI: 10.1016/j.jrras.2025.102102
Jie Wang , Anis Ben Ghorbal , Sadia Nadir , Abdulrahman M.A. Aldawsari
In real-world situations, a significant research focus is the development of innovative probabilistic techniques to accurately describe the phenomena being studied. These probabilistic techniques are efficiently employed to optimally depict real-world data in different practical fields. Acknowledging the important role of probabilistic techniques in practical situations, this paper introduces a new probability distribution. The proposed research focuses on applying the Lomax distribution and a cosine-oriented distributional technique to introduce a novel distribution termed the new cosine-trigonometric-Lomax (NCT-Lomax) distribution. Our analysis indicates that the NCT-Lomax distribution exhibits increased distributional flexibility, heavy-tailed characteristics, and optimal performance in modeling real-world data sets. We derive various mathematical characteristics of the NCT-Lomax distribution that are essential for understanding its behavior. Additionally, we explore various estimation techniques to obtain the estimators for the NCT-Lomax distribution. Furthermore, a simulation analysis was performed to assess the effectiveness of these techniques. To achieve benefits in practical situations, we utilize the NCT-Lomax distribution with two actual data sets from accounting and radiation-related domains. We showcase the practical benefits of the NCT-Lomax distribution compared to the Lomax distribution and its other variations by using three goodness-of-fit metrics and p-values. Our empirical analysis reveals that the NCT-Lomax distribution consistently surpassed the Lomax distribution and its various alternatives in offering the most suitable fit for the accounting and radiation data sets.
在现实世界中,一个重要的研究重点是发展创新的概率技术,以准确地描述所研究的现象。这些概率技术被有效地用于最优地描述不同实际领域的真实数据。鉴于概率技术在实际应用中的重要作用,本文引入了一种新的概率分布。本研究的重点是应用Lomax分布和一种面向余弦的分布技术,引入一种新的分布,称为新余弦-三角-Lomax (NCT-Lomax)分布。我们的分析表明,NCT-Lomax分布在建模真实数据集时表现出更高的分布灵活性、重尾特征和最佳性能。我们推导了NCT-Lomax分布的各种数学特征,这些特征对于理解其行为至关重要。此外,我们探索了各种估计技术来获得NCT-Lomax分布的估计量。此外,还进行了模拟分析,以评估这些技术的有效性。为了在实际情况中实现效益,我们利用NCT-Lomax分布,其中包含来自会计和辐射相关领域的两个实际数据集。通过使用三个拟合优度指标和p值,我们展示了NCT-Lomax分布与Lomax分布及其其他变体相比的实际优势。我们的实证分析表明,在提供最适合会计和辐射数据集的数据方面,NCT-Lomax分布始终优于Lomax分布及其各种替代分布。
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引用次数: 0
Exploring thermodynamic processes through CFD of free convection of Bingham fluids in innovative hexagonal enclosure (Papanastasiou model) 利用CFD研究Bingham流体在创新六角形壳体(Papanastasiou模型)中自由对流的热力学过程
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-01-04 DOI: 10.1016/j.jrras.2026.102161
Benhanifia Kada , Mebarki Brahim , Ahmed Remlaoui , Keddar Mohammed , Syed M. Hussain , Hijaz Ahmad , Neissrien Alhubieshi , Assmaa Abd-Elmonem , Bandar M. Fadhl , Basim M. Makhdoum
This research presents a unique enclosure geometry, namely, a hexagonal finned cavity, for the analysis of Bingham–Papanastasiou fluid natural convection, which is examined numerically through COMSOL Multiphysics. The momentum and energy equations that govern the phenomena are solved via the Galerkin approach. The external walls have been assumed to be cold, while the inner wall has been taken as hot. A thorough investigation of the thermo-hydrodynamic flow is carried out considering the nominal value of the Rayleigh number (Ra), the range of plasticity Bn (1–50), and the obstacle lengths L (0.1, 0.4). The findings demonstrate that the rate of heat transfer (Nu) is positively correlated with the buoyancy parameter (Ra) while it is inversely related to the plasticity parameter (Bn), with larger values of the latter resulting in lesser heat transfer. This reduction seems to occur due to lame yield stress at a bigger Bn, damping the fluid flow inside the enclosure. The streamline patterns further confirm this trend, showing a significant weakening of circulation at high plasticity levels, particularly for Bn = 50. The effect of obstacle length can be seen on the streamline and isotherm contours, which may indicate the intermediate fin length (L = 0.2) for Rayleigh Number (Ra) as the best, as it increases vortex creation and supports good circulation in the cavity, thus enhancing the heat transfer performance.
本研究提出了一种独特的封闭几何形状,即六角形翅片腔,用于分析Bingham-Papanastasiou流体自然对流,并通过COMSOL Multiphysics进行了数值研究。控制这些现象的动量和能量方程通过伽辽金方法求解。外墙被假定为冷的,而内墙被假定为热的。考虑瑞利数(Ra)的标称值、塑性范围Bn(1-50)和障碍物长度L(0.1, 0.4),对热流体动力流动进行了深入的研究。结果表明:换热速率Nu与浮力参数Ra成正相关,与塑性参数Bn成负相关,后者值越大换热越小。这种减少似乎是由于较大Bn时的屈服应力减弱,从而抑制了外壳内的流体流动。流线模式进一步证实了这一趋势,表明在高塑性水平下环流明显减弱,特别是Bn = 50时。障碍物长度对流线和等温线的影响可以看出,对于瑞利数(Ra),中间翅片长度(L = 0.2)是最好的,它增加了涡流的产生,支持了腔内良好的循环,从而提高了换热性能。
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引用次数: 0
On the exponent power sine Lomax distribution with applications in the music education and radiation fields 指数幂正弦Lomax分布及其在音乐教育和辐射领域的应用
IF 2.5 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2025-12-17 DOI: 10.1016/j.jrras.2025.102109
Yuwei Zhang , Qimeng Mao , Jun Xu , Hassan M. Aljohani , Bassant Elkalzah , Ghareeb A. Marei
Considering the decisive role of probability distributions in applied fields, we consider and implement a new probability distribution. The proposed distribution is a sine-oriented modification of the Lomax distribution by modifying the power Lomax distribution, and is called the exponent sine power Lomax (ESP-Lomax) distribution. We go into the computation of the mathematical properties and analytical studies based on these properties of the ESP-Lomax distribution. In addition, this paper also provides the mathematical derivation of the heavy-tailed characteristics of the ESP-Lomax distribution. The mathematical computation of maximum likelihood estimators and simulation studies under various parameter settings based on the ESP-Lomax distribution is also provided. In comparison with other distributions, we check and establish the practical superiority of the ESP-Lomax distribution using two practical data sets, which are sourced from two different applied sectors. By employing several key tools, we empirically demonstrated that the ESP-Lomax distribution can fit real-world events well across various domains.
考虑到概率分布在应用领域中的决定性作用,我们考虑并实现了一种新的概率分布。所提出的分布是通过修正幂Lomax分布对Lomax分布进行的一种面向正弦的修正,称为指数正弦幂Lomax (ESP-Lomax)分布。我们将根据ESP-Lomax分布的这些性质进行数学性质的计算和分析研究。此外,本文还给出了ESP-Lomax分布重尾特性的数学推导。给出了基于ESP-Lomax分布的极大似然估计的数学计算和各种参数设置下的仿真研究。与其他分布相比,我们使用来自两个不同应用部门的两个实际数据集来检验并建立ESP-Lomax分布的实际优势。通过使用几个关键工具,我们从经验上证明了ESP-Lomax分布可以很好地适应不同领域的真实事件。
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引用次数: 0
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Journal of Radiation Research and Applied Sciences
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