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2016 IEEE International Conference on Semiconductor Electronics (ICSE)最新文献

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HIV-1 Tat peptide detection by using RNA aptamer on MWCNT modified electrode MWCNT修饰电极上RNA适体检测HIV-1 Tat肽
Pub Date : 2016-08-01 DOI: 10.1109/SMELEC.2016.7573627
M. S. Radhi, A. R. Ruslinda, M. F. Fatin, S. S. B. Hashwan, M. Arshad, U. Hashim
An electrode has been fabricated for detection of HIV-1 Tat protein. Functionalized carboxylated multiwalled carbon nanotube (COOH-MWCNT) has been deposited by spray technique on the electrode to act as amplification layer and immobilization site for aptamer. Aptamer has been proved that it is highly specific for the detection of its target molecule. In this paper, we demonstrated the immobilization of split aptamer on MWCNT-modified electrode by interaction of carboxyl functional group from MWCNT and amine functional group from aptamer. The implementation of split RNA aptamer as a recognition element is promising for detecting HIV-1 Tat peptide. Detection has been conducted in control sample and HIV-1 Tat protein sample. The intercalation of aptamer and protein has given changes to the electrical signal and quantified by picoammeter showing decrease in current value of 3.74nA compared to control which different only 1.64nA.
制备了一种检测HIV-1 Tat蛋白的电极。采用喷雾法制备羧基化功能化多壁碳纳米管(COOH-MWCNT)作为适配体的扩增层和固定位点。适体已被证明对其靶分子的检测具有高度的特异性。本文利用纳米碳纳米管的羧基官能团和胺基官能团的相互作用,证明了分裂适体在纳米碳纳米管修饰电极上的固定化。分裂RNA适体作为识别元件的实现有望用于检测HIV-1 Tat肽。对对照样品和HIV-1 Tat蛋白样品进行了检测。适配体和蛋白质的插入使电信号发生变化,并通过皮安计进行了量化,结果显示电流值比对照组减少了3.74nA,仅相差1.64nA。
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引用次数: 2
Finite element analysis on mechanical characteristic of nanoslit filtration membrane for artificial kidney 人工肾用纳米缝隙过滤膜力学特性的有限元分析
Pub Date : 2016-08-01 DOI: 10.1109/SMELEC.2016.7573581
K. Mustafa, J. Yunas, A. A. Hamzah, B. Majlis
FE analysis on mechanical characteristic of nanoslit membranes have been conducted. The study is aimed to investigate the feasibility of filtration membrane fabrication for an artificial kidney. The analysis is done using Comsol Multiphysics simulation on various slit geometry ranging from 6 to 40 nm width, and for 60 and 100 nm length on Si3N4 based filtration membrane having thickness ranging from 100 to 1000 nm in order to find optimum mechanical characteristic of the membrane. It is shown that the filtration membrane having thickness of above 400 nm has an appropriate mechanical strength to withstand applied pressure up to 55 mmHg. The larger the nanoslit size, the lower the deflection of the membrane due to stress imposed. The simulated result of the nanoslit filtration membrane can be used as a reference for the future fabrication of molecule selective filtration membrane for artificial kidney.
对纳米缝膜的力学特性进行了有限元分析。本研究旨在探讨制备人工肾用过滤膜的可行性。利用Comsol Multiphysics对厚度为100 ~ 1000 nm的Si3N4基过滤膜上宽度为6 ~ 40 nm、长度为60 ~ 100 nm的不同狭缝几何形状进行了分析,以找出膜的最佳力学特性。结果表明,厚度在400纳米以上的过滤膜具有适当的机械强度,可以承受高达55毫米汞柱的施加压力。纳米狭缝尺寸越大,薄膜由于施加的应力而产生的偏转越小。纳米缝隙过滤膜的模拟结果可为今后制备分子选择性人工肾过滤膜提供参考。
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引用次数: 4
FDTD numerical analysis of SPR sensing using graphene-based photonic crystal 石墨烯基光子晶体SPR传感的FDTD数值分析
Pub Date : 2016-08-01 DOI: 10.1109/SMELEC.2016.7573595
K. A. Tarumaraja, P. Menon, F. A. Said, N. A. Jamil, A. Ehsan, S. Shaari, B. Majlis, A. Jalar
In this study, we investigated the surface plasmon resonance (SPR) sensing based on photonic crystal structures which are designed using a single graphene sheet and multilayer metal oxides (Al2O3 and ZnO) for detection sensitivity and the absorption of molecules through excitation wavelength when using air and water as analytes. The refractive index (η) of air is 1.0 and water is 1.33. The method used to investigate the design structure is by simulation using finite difference time domain (FDTD). The wavelength is fixed at 0.8μm (near-infrared region) to excite a transverse electric (TEM) surface plasmon polaritons using Kretschmann configuration. Both analytical and numerical SPR spectra were in a good agreement. When using air as analyte, the reflection of incident angle for Al2O3 and ZnO are 59.6° and 62°. While, the reflection of incident angle for Al2O3 and ZnO are 69.6° and 71.8° when using water as analyte. The change in the refractive index of the analytes gave a change in the incident angle hence graphene and metal oxides can be used to form a SPR-based biosensor for biomedical applications.
在本研究中,我们研究了基于单石墨烯片和多层金属氧化物(Al2O3和ZnO)设计的光子晶体结构的表面等离子体共振(SPR)传感,以空气和水为分析物时,探测灵敏度和分子通过激发波长的吸收。空气的折射率为1.0,水的折射率为1.33。采用时域有限差分法(FDTD)对设计结构进行仿真研究。波长固定在0.8μm(近红外区),利用Kretschmann组态激发出横向电(TEM)表面等离子体激元。SPR的解析谱与数值谱吻合较好。当分析物为空气时,Al2O3和ZnO的反射入射角分别为59.6°和62°。当分析物为水时,Al2O3和ZnO的反射角分别为69.6°和71.8°。分析物折射率的变化导致入射角的变化,因此石墨烯和金属氧化物可用于形成基于spr的生物医学应用的生物传感器。
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引用次数: 8
Surface morphology of reduced graphene oxide-carbon nanotubes hybrid film for bio-sensing applications 用于生物传感应用的还原氧化石墨烯-碳纳米管杂化膜的表面形貌
Pub Date : 2016-08-01 DOI: 10.1109/SMELEC.2016.7573656
H. Koay, A. R. Ruslinda, S. S. B. Hashwan, M. F. Fatin, V. Thivina, V. Tony, M. K. Md Arshad, C. Voon, U. Hashim
Graphene is one of the carbon allotropes that possesses several outstanding properties which is suitable to be used in bio-sensing applications. Reduction of graphene oxide (GO) is the main concern of researchers in preparing better quality of graphene at a lower cost with mass production as the reduced GO partially restores the pristine graphene. The reduced graphene oxide (rGO) is then mixed with multi-walled carbon nanotubes (MWCNTs) to form the three-dimensional arrangement of rGO-CNTs hybrid nanocomposite which can overcome the limitations faced while using rGO or MWCNTs separately in bio-sensing applications. Here we demonstrate the sample preparation of rGO-CNTs hybrid film for biosensing applications. GO was prepared by modified Hummer's method and rGO was obtained by reducing GO with L-ascorbic acid. The characterizations of rGO-CNTs hybrid film were examined via Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM) and Fourier Transform Infrared Spectroscopy (FTIR). The surface morphologies of GO, MWCNTs, GO-CNTs hybrid and rGO-CNTs hybrid films were observed via SEM. The thickness and the surface roughness of MWCNTs, GO, GO-CNTs hybrid and rGO-CNTs hybrid films were examined via AFM. FTIR was carried out to examine the carboxyl functional group in the rGO-CNTs hybrid film.
石墨烯是碳的同素异形体之一,具有许多突出的特性,适合用于生物传感领域。氧化石墨烯(GO)的还原是研究人员以更低成本批量生产更高质量石墨烯的主要关注点,因为还原的氧化石墨烯可以部分还原原始石墨烯。然后将还原的氧化石墨烯(rGO)与多壁碳纳米管(MWCNTs)混合,形成三维排列的rGO- cnts混合纳米复合材料,克服了单独使用rGO或MWCNTs在生物传感应用中所面临的局限性。在这里,我们展示了用于生物传感应用的rGO-CNTs杂化膜的样品制备。采用改进的Hummer法制备氧化石墨烯,用l -抗坏血酸还原氧化石墨烯得到还原氧化石墨烯。通过扫描电镜(SEM)、原子力显微镜(AFM)和傅里叶变换红外光谱(FTIR)对rGO-CNTs杂化膜进行表征。通过SEM观察了GO、MWCNTs、GO- cnts杂化膜和rGO-CNTs杂化膜的表面形貌。通过原子力显微镜检测了MWCNTs、GO、GO- cnts杂化膜和rGO-CNTs杂化膜的厚度和表面粗糙度。利用FTIR对rGO-CNTs杂化膜中的羧基官能团进行了检测。
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引用次数: 3
Interdigitated electrode biosensor on graphene oxide-multiwalled carbon nanotubes for DNA detection 用于DNA检测的氧化石墨烯-多壁碳纳米管交叉电极生物传感器
Pub Date : 2016-08-01 DOI: 10.1109/SMELEC.2016.7573655
S. S. B. Hashwan, A. R. Ruslinda, M. F. Fatin, M. K. Md Arshad, V. Thivina, V. Tony, C. Voon, R. M. Ayub, U. Hashim
interdigitated electrodes (IDEs) with GO-MWCNTs thin film as sensing membrane have been successfully developed on silicon substrate for DNA detection. The physical surface morphology of GO-MWCNTs were characterized using field emission scanning electron microscopy (FESEM) and the surface structural was determined by X-ray powder diffraction (XRD). The chemical bonding of GO-MWCNTs were examined by using Fourier transform infrared spectroscopy (FTIR). FTIR spectrum successfully shows that the GO-MWCNT hybrid thin film contained carboxyl functional groups by showing peaks at 3375cm -1 and 1690cm -1 for (O-H stretch), and (C=O stretch) respectively. The IDE biosensor was measured on DNA immobilization activities. The current of the IDE after the immobilization at 2V was drop from 0.9mA to 0.75mA. The difference of the current signal is due to the negatively charged backbones of the DNA probes repelled electrons from accumulating at the conducting channel. The IDE current was further decreased when the DNA hybridization took place.
以氧化石墨烯- mwcnts薄膜为传感膜,在硅衬底上成功地制备了用于DNA检测的交叉指状电极。采用场发射扫描电镜(FESEM)和x射线粉末衍射(XRD)对GO-MWCNTs的表面形貌进行了表征。利用傅里叶变换红外光谱(FTIR)研究了氧化石墨烯- mwcnts的化学键。FTIR光谱成功地表明GO-MWCNT杂化薄膜含有羧基官能团,(O- h拉伸)和(C=O拉伸)分别在3375cm -1和1690cm -1处出现峰值。测定了IDE生物传感器的DNA固定化活性。2V固定后IDE电流由0.9mA降至0.75mA。电流信号的差异是由于带负电荷的DNA探针的骨干排斥电子积聚在导电通道。当DNA杂交发生时,IDE电流进一步降低。
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引用次数: 1
Modeling of MOSFET subthreshold swing mismatch with BSIM4 Model 基于BSIM4模型的MOSFET亚阈值摆幅失配建模
Pub Date : 2016-08-01 DOI: 10.1109/SMELEC.2016.7573597
Xing Er Bee, Mohamad Marzuki Bin Mohd Fauzi, P. Tan
In this paper, we propose a methodology to model the MOSFET subthreshold swing, S mismatch by using BSIM4 model. The 0.18μm CMOS technology silicon data show two trends in the swing mismatch plot. For large-size devices (larger than a critical area AC), the subthreshold swing behaves in a linear trend with smaller slope compared to small-size devices. A mathematical equation as a function of AC is added into the BSIM4 subthreshold swing parameter, nfactor to capture the subthreshold swing mismatch correctly. The mismatch models generated using the proposed methodology shows good agreement with the silicon data and has been tested compatible with HSPICE and SPECTRE simulators.
本文提出了一种利用BSIM4模型对MOSFET亚阈值摆幅S失配进行建模的方法。0.18μm CMOS工艺的硅数据在摆幅失配图中显示出两种趋势。对于大尺寸器件(大于临界面积AC),与小尺寸器件相比,阈下摆幅呈线性趋势,斜率较小。在BSIM4的亚阈值摆幅参数中加入了一个与交流有关的数学方程,以正确捕获亚阈值摆幅失配。使用所提出的方法生成的不匹配模型与硅数据吻合良好,并已与HSPICE和SPECTRE模拟器进行了兼容测试。
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引用次数: 4
Design and fabrication of Interdigitated Electrode (IDE) for detection of Ganoderma boninense 用交叉指状电极(IDE)检测灵芝的设计与制备
Pub Date : 2016-08-01 DOI: 10.1109/SMELEC.2016.7573588
V. Thivina, U. Hashim, M. Arshad, A. R. Ruslinda, A. Ayoib, N. Nordin
As a present work, a capacitive electrochemical biosensor i.e. Interdigitated Elecrode (IDE) was successfully designed and fabricated with aluminium as its contact pad deposited on a semi-conductor (silicon) surface using a thermal evaporator. For the fabrication method, lift-off photolithography process is applied followed by morphological and electrical characterizations. Meanwhile, the design of the IDE mask was done by the aid of AutoCAD software with miniaturization for future work of Ganoderma boninense detection. The electrical performance of the microelectrode sensor proved to be remarkable and for further studies, surface modification need to be done for sensing of biomolecules especially the target DNA Ganoderma. This study has proven that with the simple process of photolithography, IDEs can be fabricated within few hours and with low cost.
本研究成功地设计并制造了一种电容式电化学生物传感器,即interdigated Elecrode (IDE),该传感器采用热蒸发器将铝作为触点垫沉积在半导体(硅)表面。对于制造方法,首先采用剥离光刻工艺,然后进行形态学和电学表征。同时,借助具有小型化特点的AutoCAD软件完成了IDE掩模的设计,为今后的灵芝检测工作打下基础。微电极传感器的电学性能已被证明是显著的,在进一步的研究中,需要对其表面进行修饰,以便对生物分子特别是目标DNA灵芝进行传感。本研究证明,采用简单的光刻工艺,可以在数小时内以较低的成本制备ide。
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引用次数: 8
Electrical characterization of surface modified IDE with Gold Nano particles 金纳米颗粒表面修饰IDE的电学特性
Pub Date : 2016-08-01 DOI: 10.1109/SMELEC.2016.7573622
N. Nordin, U. Hashim, A. R. Ruslinda, A. Ayoib, V. Thivina
Interdigitated Electrode (IDE) is a sensor device that composed of the fingers of the electrode and two pads made up of high conductivity of the metal. IDE is prepared by simple photolithographic process that included transferred of the desired design pattern to the Silicon Oxide (SiO) substrate. 130nm nanogap of IDE is used for this experiment. This paper is conducted to compare the bare IDE without anything deposited on it and IDE with Gold Nanoparticles (GNP) on it. The result showed the difference by IDE deposited GNP slightly decreased with 1.76×10-11. The size of the nanogap also played an important role for sensitivity of the device. Thus, in the future, this device should have been made to detect any kind of biomolecules such as DNA, proteins or antibodies.
交叉指电极(IDE)是一种由电极的手指和由高导电性金属制成的两个衬垫组成的传感器装置。IDE是通过简单的光刻工艺制备的,包括将所需的设计图案转移到氧化硅(SiO)衬底上。本实验采用IDE的130nm纳米间隙。本文比较了没有沉积任何东西的IDE和带有金纳米颗粒(GNP)的IDE。结果表明:随着1.76×10-11的增加,IDE沉积GNP的差异略有减小。纳米间隙的大小对器件的灵敏度也起着重要的作用。因此,在未来,这种装置应该可以用来检测任何种类的生物分子,如DNA、蛋白质或抗体。
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引用次数: 1
Accurate BSIM4 MOS model extraction with Binning-Hybrid-Macro methodology 基于Binning-Hybrid-Macro方法的BSIM4 MOS模型精确提取
Pub Date : 2016-08-01 DOI: 10.1109/SMELEC.2016.7573598
Chiew Ching Tan, P. Tan
An accurate BSIM4 parameter extraction with Binning-Hybrid-Macro (BHM) methodology has been developed for MOS transistor models. The basic idea of this method is to apply binning on a hybrid-macro model. The comparison between the BHM method and various model extraction methods is discussed. BHM method is more robust and easier to use besides its capability to produce more accurate roll-off fittings compared to other methods. The BHM extraction methodology has been demonstrated on actual silicon from 0.18μm CMOS technology. Accurate model fitting to the measured data has been achieved. The model extracted using BHM method has been tested and verified to be compatible with HSPICE and SPECTRE simulators.
针对MOS晶体管模型,提出了一种基于binning - hybridmacro (BHM)方法的精确BSIM4参数提取方法。该方法的基本思想是在混合宏观模型上应用分形。讨论了BHM方法与各种模型提取方法的比较。与其他方法相比,BHM方法更坚固,更容易使用,而且能够生产更精确的滚压管件。该BHM提取方法已在0.18μm CMOS工艺的实际硅上进行了验证。对实测数据进行了精确的模型拟合。采用BHM方法提取的模型已经过测试和验证,与HSPICE和SPECTRE模拟器兼容。
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引用次数: 1
FEM modeling and simulation of a layered SAW device based on ZnO/128° YX LiNbO3 基于ZnO/128°YX LiNbO3的层状SAW器件有限元建模与仿真
Pub Date : 2016-08-01 DOI: 10.1109/SMELEC.2016.7573577
Z. T. Salim, Uda Hashim, M. Arshad
In this paper, the modeling and simulation of a layered surface acoustic wave device based on ZnO/128° YX LiNbO3 were conducted using Finite Element Method (FEM) in COMSOL Multiphysics 4.3b platform. The SAWs propagation characteristics were numerically investigated with variation in the ZnO layer thickness. The results show that the SAW device frequency response was varied with the ZnO layer thickness from 166.1 MHz to 150.4 MHz. The free and metalized phase velocities (νf and νm) were calculated and used to calculate the electromechanical coupling coefficient (K2) of the structure. The results show that a large coupling coefficient of 6.05% can be obtained in 500 nm ZnO layer thickness which is in a good agreement with the data published by Nakamura and Hanamoka.
本文在COMSOL Multiphysics 4.3b平台上,采用有限元法对基于ZnO/128°YX LiNbO3的层状表面声波器件进行建模与仿真。数值研究了ZnO层厚度变化对saw传播特性的影响。结果表明:ZnO层厚度在166.1 MHz ~ 150.4 MHz范围内,SAW器件的频率响应随ZnO层厚度的变化而变化;计算了自由相速度和金属化相速度νf和νm,并用它们计算了结构的机电耦合系数K2。结果表明,在500 nm的ZnO层厚度上可以获得6.05%的大耦合系数,这与Nakamura和Hanamoka发表的数据吻合得很好。
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引用次数: 8
期刊
2016 IEEE International Conference on Semiconductor Electronics (ICSE)
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