Pub Date : 2024-04-24DOI: 10.18502/ssu.v32i2.15381
Samira Mozaffari Khosravi, Saman Seyedabadin, S. Shahcheraghi, Marzieh Lotfi
Introduction: Women of reproductive age may encounter challenges related to infertility or miscarriage, due to conditions such as premature ovarian failure (POF). POF, affecting approximately one percent of women under the age of 40, can lead to infertility. Current data have suggested that utilizing stem cell therapy was the most effective approach for treating POF compared to alternative options. Among the various stem cell types, mesenchymal stem cells derived from the umbilical cord (HUC-MSCs) was a promising choice for treatment due to its features such as relatively low immunogenicity, multipotent, multiple origins, cost-effectiveness, ease of production, and high efficiency. Conclusion: One of the ways to treat POF is the use of mesenchymal stem cells derived from the umbilical cord, these cells have an extraordinary capacity for repair and regeneration, which helps them in repairing depleted ovaries. The results of this review article indicate that the use of HUC-MSCs can be considered as a potential treatment method in these patients.
{"title":"Potential Ability of Umbilical Cord-Derived Mesenchymal Stem Cells in The Treatment of Premature Ovarian Failure","authors":"Samira Mozaffari Khosravi, Saman Seyedabadin, S. Shahcheraghi, Marzieh Lotfi","doi":"10.18502/ssu.v32i2.15381","DOIUrl":"https://doi.org/10.18502/ssu.v32i2.15381","url":null,"abstract":"Introduction: Women of reproductive age may encounter challenges related to infertility or miscarriage, due to conditions such as premature ovarian failure (POF). POF, affecting approximately one percent of women under the age of 40, can lead to infertility. Current data have suggested that utilizing stem cell therapy was the most effective approach for treating POF compared to alternative options. Among the various stem cell types, mesenchymal stem cells derived from the umbilical cord (HUC-MSCs) was a promising choice for treatment due to its features such as relatively low immunogenicity, multipotent, multiple origins, cost-effectiveness, ease of production, and high efficiency. \u0000Conclusion: One of the ways to treat POF is the use of mesenchymal stem cells derived from the umbilical cord, these cells have an extraordinary capacity for repair and regeneration, which helps them in repairing depleted ovaries. The results of this review article indicate that the use of HUC-MSCs can be considered as a potential treatment method in these patients. \u0000 ","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.18502/ssu.v32i2.15382
Ebrahim Rahbar Karbasdehi, S. Ghasemzadeh
Introduction: Considering the problems of emotion regulation and social skills in adolescents with bipolar spectrum disorders, one of the methods that can help these adolescents is psychosocial intervention. Therefore, the aim of the present study was to investigate the effectiveness of evidence-based psychosocial interventions on the recurrence of symptoms in adolescents with bipolar spectrum disorders. Methods: In the present study, keywords like psychosocial intervention, recurrence, bipolar disorder, bipolar and related disorders, and adolescence were selected based on the database of medical subject headings (MeSH) and searched on English databases such as Scopus, PsycINFO, PubMed, Web of Science, and Google Scholar in the period of 2008 (from March) to 2023 (until December). In this study, the PRISMA systematic review study reporting guide was used. Results: The results of the conducted research indicated the existence of problems in the sleep schedule, emotion regulation, social functioning, and problem-solving skills of these adolescents. Although drug interventions were the front line of mania treatment, psychosocial interventions using models such as psychoeducation, cognitive-behavioral therapy focused on children and families, dialectical behavior therapy, and interpersonal as well as social rhythm therapy has helped the process of treatment stability and effectively prevent the symptoms of the disorder from returning. Conclusion: Early psychosocial treatment, along with pharmacotherapy intervention, can reduce the negative impact of symptoms and lead to improved short-term and long-term outcomes by equipping adolescents and their families with knowledge and skills to improve understanding and management of the disorder.
导言：考虑到躁狂症青少年在情绪调节和社交技能方面的问题，心理干预是帮助这些青少年的方法之一。因此，本研究旨在探讨循证社会心理干预对双相情感障碍青少年症状复发的影响。研究方法本研究以医学主题词表（MeSH）数据库为基础，选取社会心理干预、复发、双相情感障碍、双相情感障碍及相关障碍、青少年等关键词，在Scopus、PsycINFO、PubMed、Web of Science、Google Scholar等英文数据库中进行检索，检索时间为2008年（3月起）至2023年（12月止）。本研究采用了 PRISMA 系统综述研究报告指南。研究结果研究结果表明，这些青少年在睡眠时间、情绪调节、社会功能和解决问题的能力方面存在问题。虽然药物干预是躁狂症治疗的前沿，但采用心理教育、以儿童和家庭为重点的认知行为疗法、辩证行为疗法、人际关系和社会节奏疗法等模式进行的社会心理干预有助于治疗过程的稳定，并能有效防止躁狂症症状的复发。结论早期的社会心理治疗以及药物治疗干预，可以减少症状的负面影响，并通过让青少年及其家人掌握相关知识和技能来提高对该疾病的理解和管理，从而改善短期和长期疗效。
{"title":"Effectiveness of Evidence-Based Psychosocial Interventions on Recurrence of Symptoms in Adolescents with Bipolar Spectrum Disorders: A Systematic Review Study","authors":"Ebrahim Rahbar Karbasdehi, S. Ghasemzadeh","doi":"10.18502/ssu.v32i2.15382","DOIUrl":"https://doi.org/10.18502/ssu.v32i2.15382","url":null,"abstract":"Introduction: Considering the problems of emotion regulation and social skills in adolescents with bipolar spectrum disorders, one of the methods that can help these adolescents is psychosocial intervention. Therefore, the aim of the present study was to investigate the effectiveness of evidence-based psychosocial interventions on the recurrence of symptoms in adolescents with bipolar spectrum disorders. \u0000Methods: In the present study, keywords like psychosocial intervention, recurrence, bipolar disorder, bipolar and related disorders, and adolescence were selected based on the database of medical subject headings (MeSH) and searched on English databases such as Scopus, PsycINFO, PubMed, Web of Science, and Google Scholar in the period of 2008 (from March) to 2023 (until December). In this study, the PRISMA systematic review study reporting guide was used. \u0000Results: The results of the conducted research indicated the existence of problems in the sleep schedule, emotion regulation, social functioning, and problem-solving skills of these adolescents. Although drug interventions were the front line of mania treatment, psychosocial interventions using models such as psychoeducation, cognitive-behavioral therapy focused on children and families, dialectical behavior therapy, and interpersonal as well as social rhythm therapy has helped the process of treatment stability and effectively prevent the symptoms of the disorder from returning. \u0000Conclusion: Early psychosocial treatment, along with pharmacotherapy intervention, can reduce the negative impact of symptoms and lead to improved short-term and long-term outcomes by equipping adolescents and their families with knowledge and skills to improve understanding and management of the disorder.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140660888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.18502/ssu.v32i2.15387
Kimia Kalantar, A. Davari, Maede Khoshdel, Bita Ahadi, Fahimeh Shafiei
Introduction: Today, composite resins are a suitable choice for tooth restoration, which in relation to posterior teeth, the most important limitations are marginal leakage, secondary decay, poor load bearing capacity, high wear and inability to restore contact. The durability of posterior restorations especially class II restorations is less compared to amalgam restorations. This has been affected by various factors such as polymerization shrinkage, thermal expansion coefficient and abrasion resistance that limits the durability of the posterior composite. Methods: The present study was a cross-sectional descriptive study, which 68 final year dental students of School of Dentistry of Shahid Sadoughi University of Medical Sciences in Yazd City were selected by census and their attitude and awareness were studied using a valid and reliable questionnaire containing demographic characteristics and attitude as well as awareness questions. All the data were analyzed in SPSS 16 statistical software. Likert scale was used to measure awareness and attitude. Results: In the present study, among the 68 final year dental students, 37 students (54.4%) were male 31 students (45/6%) were female the mean and standard deviation of the age of the participants was 25.12 ± 2.3 years. In this study, the mean and standard deviation of total attitude score of final year dental students was equal to 22.80 ± 6.74 and the total attitude score of final year dental students based on Likert Scale was lower than the average. Most of the students reported the quality of posterior composite training to meet practical needs as poor. Conclusion: Based on the results, the awareness and attitude of final year dental students in relation to posterior composite restoration training was less than average and weak, respectively. There was no significant difference was observed between the knowledge and attitude scores with the gender and age.
{"title":"Evaluation of Knowledge and Attitude of Yazd Dental Students in Connection with the Training of Posterior Teeth Restoration with Composite in 2023","authors":"Kimia Kalantar, A. Davari, Maede Khoshdel, Bita Ahadi, Fahimeh Shafiei","doi":"10.18502/ssu.v32i2.15387","DOIUrl":"https://doi.org/10.18502/ssu.v32i2.15387","url":null,"abstract":"Introduction: Today, composite resins are a suitable choice for tooth restoration, which in relation to posterior teeth, the most important limitations are marginal leakage, secondary decay, poor load bearing capacity, high wear and inability to restore contact. The durability of posterior restorations especially class II restorations is less compared to amalgam restorations. This has been affected by various factors such as polymerization shrinkage, thermal expansion coefficient and abrasion resistance that limits the durability of the posterior composite. \u0000Methods: The present study was a cross-sectional descriptive study, which 68 final year dental students of School of Dentistry of Shahid Sadoughi University of Medical Sciences in Yazd City were selected by census and their attitude and awareness were studied using a valid and reliable questionnaire containing demographic characteristics and attitude as well as awareness questions. All the data were analyzed in SPSS 16 statistical software. Likert scale was used to measure awareness and attitude. \u0000Results: In the present study, among the 68 final year dental students, 37 students (54.4%) were male 31 students (45/6%) were female the mean and standard deviation of the age of the participants was 25.12 ± 2.3 years. In this study, the mean and standard deviation of total attitude score of final year dental students was equal to 22.80 ± 6.74 and the total attitude score of final year dental students based on Likert Scale was lower than the average. Most of the students reported the quality of posterior composite training to meet practical needs as poor. \u0000Conclusion: Based on the results, the awareness and attitude of final year dental students in relation to posterior composite restoration training was less than average and weak, respectively. There was no significant difference was observed between the knowledge and attitude scores with the gender and age.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.18502/ssu.v32i2.15388
Shahram Azarrang, Mohammad Parstesh, Abbas Saremi
Introduction: Diabetes along with morphine causes many metabolic damages in the testicles by causing oxidative stress. This study aimed to reduce the oxidative effects caused by diabetes and morphine on the fertility quality of men with the help of increasing moderate intensity aerobic exercise. Methods: 32 male Wistar rats were used in this experimental study. Mice were randomly divided into 4 groups of 8: diabetes control (D), morphine diabetes (D. M), diabetes + endurance training (D+ ET), diabetes + morphine endurance training (D. M+ ET). Then induction of diabetes and morphine was done. The training groups performed 8 weeks of endurance training protocol. At the end of the study, all mice were killed and their testis tissue was isolated. The oxidant and antioxidant indices of this study were measured. Data were analyzed by SPSS software version 16 using one-way ANOVA at a significant level of 0.05. Results: The results showed that the concentration of MDA in the diabetes group had a significant increase compared to other groups (P=0.001). However, increasing endurance training caused a significant decrease in the concentration of MDA (P=0. 001) and a significant increase in the amount of TAC, GPX and SOD (P=0. 001) in other groups compared to the diabetes group. Conclusion: The present research showed that increasing endurance training with moderate intensity caused a decrease in the oxidant index and an increase in the antioxidant index in the testicular tissue of diabetic rats with withdrawal syndrome. And this shows the reduction of infertility complications in mice.
{"title":"Effect of Eight Weeks of Endurance Training on Some Oxidant and Antioxidant Indicators of Testicular Tissue of Diabetic Rats with Acute Morphine Withdrawal Syndrome","authors":"Shahram Azarrang, Mohammad Parstesh, Abbas Saremi","doi":"10.18502/ssu.v32i2.15388","DOIUrl":"https://doi.org/10.18502/ssu.v32i2.15388","url":null,"abstract":"Introduction: Diabetes along with morphine causes many metabolic damages in the testicles by causing oxidative stress. This study aimed to reduce the oxidative effects caused by diabetes and morphine on the fertility quality of men with the help of increasing moderate intensity aerobic exercise. \u0000Methods: 32 male Wistar rats were used in this experimental study. Mice were randomly divided into 4 groups of 8: diabetes control (D), morphine diabetes (D. M), diabetes + endurance training (D+ ET), diabetes + morphine endurance training (D. M+ ET). Then induction of diabetes and morphine was done. The training groups performed 8 weeks of endurance training protocol. At the end of the study, all mice were killed and their testis tissue was isolated. The oxidant and antioxidant indices of this study were measured. Data were analyzed by SPSS software version 16 using one-way ANOVA at a significant level of 0.05. \u0000Results: The results showed that the concentration of MDA in the diabetes group had a significant increase compared to other groups (P=0.001). However, increasing endurance training caused a significant decrease in the concentration of MDA (P=0. 001) and a significant increase in the amount of TAC, GPX and SOD (P=0. 001) in other groups compared to the diabetes group. \u0000Conclusion: The present research showed that increasing endurance training with moderate intensity caused a decrease in the oxidant index and an increase in the antioxidant index in the testicular tissue of diabetic rats with withdrawal syndrome. And this shows the reduction of infertility complications in mice.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.18502/ssu.v32i2.15383
Mahshid Shiri, Mohammad Reza Fadai Chafi, S. Gholamrezaei
Introduction: Exercise training is likely to be a non-pharmacological intervention to improve bone health in children and the elderly. The aim of this study was to investigate the effect of resistance-aerobic training on RUX2, CTX, RANKL and ALP biomarkers in rats of different ages. Methods: In the present experimental study, 30 male Wistar rats were obtained from Instituto Pasteur of Iran and were divided into three groups according to their age: immature (2 weeks old), mature (6 weeks old) and elderly (96 weeks old). In each age group, the mice were randomly divided into two training (n=5) and control (n=5) groups. Six weeks of combined training included three sessions of aerobic training and three sessions of resistance training per week. Extracting genes by PCR method was used. One-way analysis of variance and Tukey's post hoc test and SPSS16 software were used. The significance level P≥0.05 was considered. Results: One-way analysis of variance showed that resistance-aerobic training has had a significant effect on RUNX2, RANKL and ALP variables of rats in different age groups (P < 0.05). This significance was not observed in CTX variable (P > 0.05). On the other hand, the results of Tukey's RUNX2 test were significantly different between the adult training and elderly training groups (p=0.019) as well as between the elderly control groups (p = 0.01) and adult training (p = 0.002). Regarding the RANKL variable, it showed that there was a significant difference only between the adult exercise group and the elderly control group (p = 0.01). Conclusion: Resistance-endurance training probably increases absorption and reabsorption biomarkers such as RUX2, RANKL and ALP in immature, mature and elderly male rats.
{"title":"Investigating the Effect of Resistance-Aerobic Training on the Absorption and Resorption Biomarkers of Bone Tissue in Young, Adult and Elderly Male Rats","authors":"Mahshid Shiri, Mohammad Reza Fadai Chafi, S. Gholamrezaei","doi":"10.18502/ssu.v32i2.15383","DOIUrl":"https://doi.org/10.18502/ssu.v32i2.15383","url":null,"abstract":"Introduction: Exercise training is likely to be a non-pharmacological intervention to improve bone health in children and the elderly. The aim of this study was to investigate the effect of resistance-aerobic training on RUX2, CTX, RANKL and ALP biomarkers in rats of different ages. \u0000Methods: In the present experimental study, 30 male Wistar rats were obtained from Instituto Pasteur of Iran and were divided into three groups according to their age: immature (2 weeks old), mature (6 weeks old) and elderly (96 weeks old). In each age group, the mice were randomly divided into two training (n=5) and control (n=5) groups. Six weeks of combined training included three sessions of aerobic training and three sessions of resistance training per week. Extracting genes by PCR method was used. One-way analysis of variance and Tukey's post hoc test and SPSS16 software were used. The significance level P≥0.05 was considered. \u0000Results: One-way analysis of variance showed that resistance-aerobic training has had a significant effect on RUNX2, RANKL and ALP variables of rats in different age groups (P < 0.05). This significance was not observed in CTX variable (P > 0.05). On the other hand, the results of Tukey's RUNX2 test were significantly different between the adult training and elderly training groups (p=0.019) as well as between the elderly control groups (p = 0.01) and adult training (p = 0.002). Regarding the RANKL variable, it showed that there was a significant difference only between the adult exercise group and the elderly control group (p = 0.01). \u0000Conclusion: Resistance-endurance training probably increases absorption and reabsorption biomarkers such as RUX2, RANKL and ALP in immature, mature and elderly male rats.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.18502/ssu.v32i2.15385
Amir Falahnezhad Mojarad, Nastaran Amini, SeyyedMostafa SeyyedAshour
Introduction: A high-fat diet and increased calorie intake increase the prevalence of obesity،,which itself causes many diseases. The studies carried out in the field of investigating the mechanisms related to obesity and its related diseases have introduced the increase of fat mass and as a result the disruption of cytokines as one of the most important influencing factors. Therefore, the aim of the current research was the effect of eight weeks of intense interval training on serum lipid peroxidation indices and adiponectin gene expression in obese mice. Methods: The current research was experimental with a control group. 24 male rats were randomly divided into three control groups, self-obesity group and self-obesity group with high intensity interval training (HIIT). The normal distribution of the data was evaluated using the Shapiro-Wilk test. Then، in order to compare data between groups، one-way analysis of variance was used, and if it became significant، the data were compared using Tukey's post hoc test at a significance level of P < 0.05. Results: The findings of this research showed that in the exercise group, there was a significant increase in the state of superoxide dismutase (SOD) compared to the self-obesity group. However,, there was no significant change in the level of malondialdehyde (MDA) and the level of adiponectin gene expression in the liver of self-obesity group and interval training group. Conclusion: Obesity causes an imbalance in the oxidative status and a disturbance in the production and secretion of adiponectin in the liver tissue of obese mice، and intense intermittent exercise improves the oxidative status, but it does not have a significant effect on the expression of the adiponectin gene.
引言高脂肪饮食和卡路里摄入量的增加增加了肥胖症的发病率。在对肥胖及其相关疾病的机制进行研究时，发现脂肪量的增加和细胞因子的紊乱是最重要的影响因素之一。因此，本研究旨在探讨八周高强度间歇训练对肥胖小鼠血清脂质过氧化指数和脂肪连通素基因表达的影响。研究方法本次研究为实验组和对照组。将 24 只雄性大鼠随机分为对照组、自我肥胖组和进行高强度间歇训练（HIIT）的自我肥胖组。数据的正态分布采用 Shapiro-Wilk 检验。然后，为了比较组间数据，采用单因素方差分析，如果差异显著，则采用 Tukey's post hoc 检验进行比较，显著性水平为 P <0.05。研究结果研究结果表明，与自我肥胖组相比，运动组的超氧化物歧化酶（SOD）含量显著增加。然而，自我肥胖组和间歇训练组肝脏中的丙二醛（MDA）水平和脂肪连接蛋白基因表达水平没有明显变化。结论肥胖会导致肥胖小鼠肝脏组织的氧化状态失衡，并干扰脂肪连通素的产生和分泌；剧烈的间歇性运动能改善氧化状态，但对脂肪连通素基因的表达没有显著影响。
{"title":"Effect of Eight Weeks of Intense Interval Training and Self-Obesity on Serum Lipid Peroxidation Status and Adiponectin Gene Expression in Obese Male Wistar Rats","authors":"Amir Falahnezhad Mojarad, Nastaran Amini, SeyyedMostafa SeyyedAshour","doi":"10.18502/ssu.v32i2.15385","DOIUrl":"https://doi.org/10.18502/ssu.v32i2.15385","url":null,"abstract":"Introduction: A high-fat diet and increased calorie intake increase the prevalence of obesity،,which itself causes many diseases. The studies carried out in the field of investigating the mechanisms related to obesity and its related diseases have introduced the increase of fat mass and as a result the disruption of cytokines as one of the most important influencing factors. Therefore, the aim of the current research was the effect of eight weeks of intense interval training on serum lipid peroxidation indices and adiponectin gene expression in obese mice. \u0000Methods: The current research was experimental with a control group. 24 male rats were randomly divided into three control groups, self-obesity group and self-obesity group with high intensity interval training (HIIT). The normal distribution of the data was evaluated using the Shapiro-Wilk test. Then، in order to compare data between groups، one-way analysis of variance was used, and if it became significant، the data were compared using Tukey's post hoc test at a significance level of P < 0.05. \u0000Results: The findings of this research showed that in the exercise group, there was a significant increase in the state of superoxide dismutase (SOD) compared to the self-obesity group. However,, there was no significant change in the level of malondialdehyde (MDA) and the level of adiponectin gene expression in the liver of self-obesity group and interval training group. \u0000Conclusion: Obesity causes an imbalance in the oxidative status and a disturbance in the production and secretion of adiponectin in the liver tissue of obese mice، and intense intermittent exercise improves the oxidative status, but it does not have a significant effect on the expression of the adiponectin gene.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140661517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.18502/ssu.v32i1.15227
Fatemeh Lotfi Dashbelagh, Sara Ghaffarian
Introduction: The TP53 gene on the short arm of chromosome 17p, which is known as a tumor suppressor gene, encodes the transcription factor p53, and this factor controls cell cycle progression. This study was done to assess the association of TP53 (rs12602273C>G) gene polymorphism with the risk and prognosis of breast cancer in women of northwest of Iran. Methods: In this case-control study, the association of TP53 (rs12602273C>G) gene polymorphism with breast cancer risk was studied in a population, including 100 patients and 100 healthy individuals was investigated by Tetra ARMS-PCR technique. The analysis of the resulting data was done using SPSS version 16 software and JavaStat online statistics package. Results: In the case group, the frequency of CC, CG, and GG genotypes were 81.52, 16.3, 2.17 percent, respectively and they were 79.34, 17.39, and 3.26 percent for the control group. Similarly, C and G allele frequency in case group was 89.67 and 10.32 percent and those in the control group was 88.04 and 11.95 percent, respectively. Statistical analyzes showed no association between genotypic (P>0.05) and allelic (P>0.05) polymorphism (rs12602273C>G) of TP53 gene with breast cancer. Also, the results showed that the studied polymorphism was not associated with the clinical characteristics of breast cancer patients in the Northwest of Iran (P>0.05). Conclusion: These research findings suggest that TP53 polymorphism of rs12602273C>G is not related to the risk of breast cancer. The association of the genotypic distribution of this SNP with the clinical characteristics of the patients was insignificant.
{"title":"Study the Association between TP53 (rs12602273C>G) Gene Polymorphism with Susceptibility to the Breast Cancer in North West of Iran","authors":"Fatemeh Lotfi Dashbelagh, Sara Ghaffarian","doi":"10.18502/ssu.v32i1.15227","DOIUrl":"https://doi.org/10.18502/ssu.v32i1.15227","url":null,"abstract":"Introduction: The TP53 gene on the short arm of chromosome 17p, which is known as a tumor suppressor gene, encodes the transcription factor p53, and this factor controls cell cycle progression. This study was done to assess the association of TP53 (rs12602273C>G) gene polymorphism with the risk and prognosis of breast cancer in women of northwest of Iran. \u0000Methods: In this case-control study, the association of TP53 (rs12602273C>G) gene polymorphism with breast cancer risk was studied in a population, including 100 patients and 100 healthy individuals was investigated by Tetra ARMS-PCR technique. The analysis of the resulting data was done using SPSS version 16 software and JavaStat online statistics package. \u0000Results: In the case group, the frequency of CC, CG, and GG genotypes were 81.52, 16.3, 2.17 percent, respectively and they were 79.34, 17.39, and 3.26 percent for the control group. Similarly, C and G allele frequency in case group was 89.67 and 10.32 percent and those in the control group was 88.04 and 11.95 percent, respectively. Statistical analyzes showed no association between genotypic (P>0.05) and allelic (P>0.05) polymorphism (rs12602273C>G) of TP53 gene with breast cancer. Also, the results showed that the studied polymorphism was not associated with the clinical characteristics of breast cancer patients in the Northwest of Iran (P>0.05). \u0000Conclusion: These research findings suggest that TP53 polymorphism of rs12602273C>G is not related to the risk of breast cancer. The association of the genotypic distribution of this SNP with the clinical characteristics of the patients was insignificant.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140371857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Treatment of root-treated teeth depends largely on proper restoration. Direct restorations are a better choice if there is sufficient residual tissue. This study aimed to investigate the knowledge of dental students in School of Dentistry in Yazd City about the taught factors of direct restoration of endodontically treated teeth. Methods: In this descriptive-cross-sectional study, the knowledge of 67 dental students of School of Dentistry in Yazd City about the taught factors of direct restoration of root-treated teeth was studied using a valid and reliable questionnaire containing demographic characteristics (age and gender) and 28 knowledge questions. After collecting the data, using SPSS version 16 software, they were analyzed using descriptive statistics, Chi-square test, Fisher's exact test, Mann-Whitney test, T test and Pearson correlation coefficient. Results: 36 (53.7%) female students and 31 (46.3%) male students with an average age of 25 ± 3.14 participated in this study. The average awareness score was 32.74 ± 9.65. The average knowledge score of female students (35.30±10.27) was higher than that of male students (31.95±8.70), but this difference was not statistically significant (p = 0.156). In the age group under 25, the average score of awareness (34.78 ± 9.94) was higher than the average above 25 (30.43 ± 8.1). There was an inverse and significant relationship between knowledge score and age, r=-0.242 and P 0.049. Conclusion: The average knowledge score of dental students regarding the taught factors of direct restoration of endodontically treated teeth was good. Gender did not have a significant effect on the knowledge of students, and the knowledge of students under 25 years old was higher than ones over 25 years old.
{"title":"Investigating the Knowledge of Yazd Dental Students about the Taught Factors of Direct Restoration of Endodontically Treated Teeth in 1401","authors":"Fatemeh Yavari, Farnaz Farahat, Bita Ahadi, Maede Khoshdel, Fahimeh Shafiei","doi":"10.18502/ssu.v32i1.15230","DOIUrl":"https://doi.org/10.18502/ssu.v32i1.15230","url":null,"abstract":"Introduction: Treatment of root-treated teeth depends largely on proper restoration. Direct restorations are a better choice if there is sufficient residual tissue. This study aimed to investigate the knowledge of dental students in School of Dentistry in Yazd City about the taught factors of direct restoration of endodontically treated teeth. \u0000Methods: In this descriptive-cross-sectional study, the knowledge of 67 dental students of School of Dentistry in Yazd City about the taught factors of direct restoration of root-treated teeth was studied using a valid and reliable questionnaire containing demographic characteristics (age and gender) and 28 knowledge questions. After collecting the data, using SPSS version 16 software, they were analyzed using descriptive statistics, Chi-square test, Fisher's exact test, Mann-Whitney test, T test and Pearson correlation coefficient. \u0000Results: 36 (53.7%) female students and 31 (46.3%) male students with an average age of 25 ± 3.14 participated in this study. The average awareness score was 32.74 ± 9.65. The average knowledge score of female students (35.30±10.27) was higher than that of male students (31.95±8.70), but this difference was not statistically significant (p = 0.156). In the age group under 25, the average score of awareness (34.78 ± 9.94) was higher than the average above 25 (30.43 ± 8.1). There was an inverse and significant relationship between knowledge score and age, r=-0.242 and P 0.049. Conclusion: The average knowledge score of dental students regarding the taught factors of direct restoration of endodontically treated teeth was good. Gender did not have a significant effect on the knowledge of students, and the knowledge of students under 25 years old was higher than ones over 25 years old.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.18502/ssu.v32i1.15228
Mahsa Bahrami, Farideh Ghelichi, Vahid Rahimizadeh, S. Talebi, Akram Sadat Mousavi Shakib, Jamal Biganeh
Introduction: Today, various platforms, including virtual networks and websites, connect people with a lot of data via Internet. The attractiveness of these platforms sometimes makes people use them addictively. Uncontrolled use of the Internet may also cause problems such as reducing academic performance and creating musculoskeletal problems. Methods: This cross-sectional study was conducted on 400 students at one of the universities of medical sciences. Four demographic questionnaires, Young's Internet addiction, Pham and Taylor's academic achievement and Nordic questionnaire were used to collect information. Data analysis was done using descriptive tests and Pearson's correlation, by SPSS V.16 software at a significance level of 0.05. Results: The highest prevalence of musculoskeletal disorders was related to the upper back (40.8%), lower back (36%) and neck (33.8%) regions. Among different parts of the body, reports of pain in the neck, shoulder, and wrist had a significant relationship with Internet addiction (P-Value: 0.038, 0.007, and 0.029, respectively). No significant relationship was found between different levels of Internet addiction and academic achievement. Conclusion: The prevalence of musculoskeletal disorders is one of the complications of incorrect and unprincipled use of Internet-related equipment; Therefore, these problems can be reduced by providing appropriate educational platforms and creating a correct culture of using emerging technologies
{"title":"Effect of Internet Addiction on Academic Achievement and Musculoskeletal Disorders of University Students","authors":"Mahsa Bahrami, Farideh Ghelichi, Vahid Rahimizadeh, S. Talebi, Akram Sadat Mousavi Shakib, Jamal Biganeh","doi":"10.18502/ssu.v32i1.15228","DOIUrl":"https://doi.org/10.18502/ssu.v32i1.15228","url":null,"abstract":"Introduction: Today, various platforms, including virtual networks and websites, connect people with a lot of data via Internet. The attractiveness of these platforms sometimes makes people use them addictively. Uncontrolled use of the Internet may also cause problems such as reducing academic performance and creating musculoskeletal problems. \u0000Methods: This cross-sectional study was conducted on 400 students at one of the universities of medical sciences. Four demographic questionnaires, Young's Internet addiction, Pham and Taylor's academic achievement and Nordic questionnaire were used to collect information. Data analysis was done using descriptive tests and Pearson's correlation, by SPSS V.16 software at a significance level of 0.05. \u0000Results: The highest prevalence of musculoskeletal disorders was related to the upper back (40.8%), lower back (36%) and neck (33.8%) regions. Among different parts of the body, reports of pain in the neck, shoulder, and wrist had a significant relationship with Internet addiction (P-Value: 0.038, 0.007, and 0.029, respectively). No significant relationship was found between different levels of Internet addiction and academic achievement. \u0000Conclusion: The prevalence of musculoskeletal disorders is one of the complications of incorrect and unprincipled use of Internet-related equipment; Therefore, these problems can be reduced by providing appropriate educational platforms and creating a correct culture of using emerging technologies","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140370225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.18502/ssu.v32i1.15226
Abbas Khalili
Introduction: Inborn error of immunity (IEI) includes variety of genetic disorders that affect both the innate and acquired immune system. The number of primary immune deficiency disorders is increasing due to advanced laboratory testing methods. The patients with IEI are susceptible to multiple infectious and non-infectious diseases، including autoimmune disorders، allergies، and malignancies. Several studies have shown an increasing prevalence of non-infectious disorders in patients in IEI. Among the non-infectious manifestations of primary immunodeficiency، allergic symptoms can play an effective and important role in diagnosis and treatment of these patients. Methods: Articles were searched in Google Scholar، PubMed، Web of Science، and Scopus databases. In this review، we have tried to use the latest and most reliable articles related to the subject that have been published in Persian and English language. Conclusion: Allergic diseases can be a common part of some primary immunodeficiency diseases. Even in some types of primary immunodeficiency، they are considered the main symptom and important indicator of the disease، which are very decisive factors for the diagnosis of immunodeficiency.
导言先天性免疫缺陷（IEI）包括各种影响先天性和获得性免疫系统的遗传疾病。由于采用了先进的实验室检测方法，原发性免疫缺陷疾病的数量正在不断增加。先天性免疫畸形患者易患多种感染性和非感染性疾病，包括自身免疫性疾病、过敏症和恶性肿瘤。多项研究显示，非感染性疾病在 IEI 患者中的发病率越来越高。在原发性免疫缺陷的非感染性表现中，过敏症状可在诊断和治疗这些患者方面发挥有效和重要的作用。研究方法在 Google Scholar、PubMed、Web of Science 和 Scopus 数据库中检索相关文章。在这篇综述中，我们尽量采用最新、最可靠的、以波斯语和英语发表的相关文章。结论过敏性疾病可能是某些原发性免疫缺陷疾病的常见组成部分。甚至在某些类型的原发性免疫缺陷病中，过敏性疾病被认为是疾病的主要症状和重要指标，是诊断免疫缺陷病的决定性因素。
{"title":"Inborn error of immunity associated with allergic and allergic like symptoms","authors":"Abbas Khalili","doi":"10.18502/ssu.v32i1.15226","DOIUrl":"https://doi.org/10.18502/ssu.v32i1.15226","url":null,"abstract":"Introduction: Inborn error of immunity (IEI) includes variety of genetic disorders that affect both the innate and acquired immune system. The number of primary immune deficiency disorders is increasing due to advanced laboratory testing methods. The patients with IEI are susceptible to multiple infectious and non-infectious diseases، including autoimmune disorders، allergies، and malignancies. Several studies have shown an increasing prevalence of non-infectious disorders in patients in IEI. Among the non-infectious manifestations of primary immunodeficiency، allergic symptoms can play an effective and important role in diagnosis and treatment of these patients. \u0000Methods: Articles were searched in Google Scholar، PubMed، Web of Science، and Scopus databases. In this review، we have tried to use the latest and most reliable articles related to the subject that have been published in Persian and English language. \u0000Conclusion: Allergic diseases can be a common part of some primary immunodeficiency diseases. Even in some types of primary immunodeficiency، they are considered the main symptom and important indicator of the disease، which are very decisive factors for the diagnosis of immunodeficiency.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140371594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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